LOCUS       NZ_MPOH02000005        23635 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces phaeoluteigriseus strain DSM 41896 Scaffold_5, whole
            genome shotgun sequence.
ACCESSION   NZ_MPOH02000005
VERSION     NZ_MPOH02000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces phaeoluteigriseus
  ORGANISM  Streptomyces phaeoluteigriseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 510511)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Draft genome sequence of Streptomyces phaeoluteigriseus type strain
            DSM41896
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 510511)
  AUTHORS   Salih,T.S., Algora Gallardo,L., Melo Santos,T., Filgueira
            Martinez,S. and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2017) Strathclyde Institute of Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
REFERENCE   3  (bases 1 to 510511)
  AUTHORS   Schniete,J.K., Salih,T., Algora Gallardo,L., Martinez Fernandez,S.
            and Herron,P.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2016) Strathclyde Institute for Pharmacy and
            Biomedical Sciences, University of Strathclyde, 161 Cathedral
            Street, Glasgow G40RE, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-JAN-2017
            Assembly Method                   :: SPAdes v. 3.9; MeDuSa v. 1.6
            Genome Coverage                   :: 65.0x
            Sequencing Technology             :: IonTorrent
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001896135.2-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:12:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,918
            CDSs (total)                      :: 7,837
            Genes (coding)                    :: 6,622
            CDSs (with protein)               :: 6,622
            Genes (RNA)                       :: 81
            rRNAs                             :: 3 (5S)
            complete rRNAs                    :: 3 (5S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 1,215
            CDSs (without protein)            :: 1,215
            Pseudo Genes (ambiguous residues) :: 0 of 1,215
            Pseudo Genes (frameshifted)       :: 907 of 1,215
            Pseudo Genes (incomplete)         :: 407 of 1,215
            Pseudo Genes (internal stop)      :: 30 of 1,215
            Pseudo Genes (multiple problems)  :: 120 of 1,215
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:00:38
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 155495
            Orig. end                         :: 179130
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MPOH02000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23635
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /product="indole"
                     /region_number="1"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..23635
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="hydrogen-cyanide"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..12967
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12967
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7967](+)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7967
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     gene            complement(<206..2241)
                     /gene="fusA"
                     /locus_tag="BM536_RS03870"
                     /old_locus_tag="BM536_003850"
                     /pseudo=""
     CDS             complement(<206..2241)
                     /GO_function="GO:0003746 - translation elongation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fusA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656269.1"
                     /locus_tag="BM536_RS03870"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="BM536_003850"
                     /product="elongation factor G"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRNNLDRHLAAVRNLGILAHVDAGKTTVTERILFATGTTHKRGEV
                     HDGTTVTDFDPQERDRGITIFAAAVSCDWDGHRVNLIDTPGHVDFADEVERSLRVLDGA
                     VAVFDAVAGVEPQSESVWRQADRHGVPRIAFVNKLDRTGADLDTTVASIRERLHPVPLV
                     VQLPIGIEDAFTGVVDLLRMRALTWGDGAETAVEGPVPEELREEALRRRRLLEEAVAER
                     HPAALEEFCDRETLSAETLAAALRDLTRTGDGVVVLCGSAYRNRGIEPLLDAVVAYLPS
                     PLDVPAVRGMHEGVDERRSADPAAPFAALAFKVNATPTGRLTYLRVYSGTIEKGDTVWD
                     ASAGRGERVGRILRVQATGTPSWSGRSPGTSWP"
     misc_feature    complement(2459..2473)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.84"
                     /tool="antismash"
     cand_cluster    2484..23635
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    2484..23635
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[12483:13635](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(12484..13635)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     gene            complement(2660..3358)
                     /locus_tag="BM536_RS03875"
                     /old_locus_tag="BM536_003855"
     CDS             complement(2660..3358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116949.1"
                     /locus_tag="BM536_RS03875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003855"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_073494481.1"
                     /transl_table=11
                     /translation="MSVQNILLSGVVGSTAYGLAHAGSDVDRLGLFAALTEELHGLHPP
                     KESHVSTAPDRTLHEAAKWCRLALGGNPTVTELVWLPTDLYEVRTPLGDELVGIRTTFL
                     SARRVRDAYLGYATQQFRRLLARGDGSFSADTRKRTAKHARHLKRLCGQGYELYTTGRL
                     SIRVDDPESFHRFGEQVADDPETALPLLRRYETAFDEARSVLPEQPDERAADAWLRRVR
                     RHFYTSARSS"
     gene            3987..4841
                     /locus_tag="BM536_RS03880"
                     /old_locus_tag="BM536_003860"
     CDS             3987..4841
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004982493.1"
                     /locus_tag="BM536_RS03880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003860"
                     /product="hypothetical protein"
                     /protein_id="WP_211362827.1"
                     /transl_table=11
                     /translation="MATGALLATAACSSGDDGAAADSETAAAVAERPVAAQTATPAPTI
                     TGSVSATPTATATSPTGTESPAAPLSETGARNALITAADIEDNWVQVKDPQAWRDKLLI
                     GEVDTAQFVTGKADAADCQRLVDALYDETLLGRPSGASALNGFQEGQSRLLYQVAAYEK
                     ASLDKSMDWLTKLPDTCDQFTLTGGDSGERTVQVVEASLPEEGDARQGLTVTVKGTANG
                     DPVTLTLDVAVVRVGDDAITITNGGLDGADEDTTRTAVEQGTERLREVQAGRTPTPTPS
                     NLD"
     gene            5001..6221
                     /locus_tag="BM536_RS03885"
                     /old_locus_tag="BM536_003865"
     CDS             5001..6221
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996369.1"
                     /locus_tag="BM536_RS03885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003865"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_094102517.1"
                     /sec_met_domain="DAO (E-value: 1.4e-58, bitscore: 194.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNQSSCDVVVVGAGMIGAACALYAVRAGLDVVVVDRGPVAGGTT
                     GAGEGNLLVSDKEPGPELELALLSCRLWRGITEDRRPDDHRPPTRGNGLGPGLTPGLGR
                     AVEYEPKGGLVVASTPGALTALTELAVGQRAAGVETVAVDANQLRELEPYLAPGLAGGV
                     LYPQDAQVMPTLAAAHLLRASGARVETGRTVTGVLRGPDGAVRGVRTDRGDLLAPSVVN
                     AAGTWGAEVAALAGVSLPVLPRRGFVVVTEPLPRRVRHKVYSADYVADVASDSATLQTS
                     PVVEGTAAGPVLIGASRERVGFDRSFSLPVVRALAAGATRLFPFLEHVRAMRAYVGFRP
                     YLPDHLPAIGPDPRAPGLFHACGHEGAGIGLATGTGHLIAQTLTGRTPDLDLTPFRPDR
                     FAEEAAP"
     gene            6218..6517
                     /locus_tag="BM536_RS03890"
                     /old_locus_tag="BM536_003870"
     CDS             6218..6517
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994282.1"
                     /locus_tag="BM536_RS03890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003870"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_094102518.1"
                     /sec_met_domain="Fer2_4 (E-value: 1.3e-27, bitscore: 90.6,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLDLVGARPGAPFTVTFDGREIEVLPGQTIAAALWSAGVVAWR
                     TTREGARPRGVFCGIGVCFDCLVTVDGRPGRRACLTPATPGADIGTQAGTGHDD"
     gene            6510..7967
                     /locus_tag="BM536_RS03895"
                     /old_locus_tag="BM536_003875"
     CDS             6510..7967
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676293.1"
                     /locus_tag="BM536_RS03895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003875"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_094102519.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.8e-25, bitscore:
                     83.6, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 9.7e-13, bitscore:
                     43.2, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERRQVLAVIGAGPAGLAAALAAAARGVRVVLVDSAAEPGGQFY
                     RQPAPGLGARRPQALHHQWRTWERLRDGLATHLAAGRVSCLSDHHVWCVERDSGRFAVH
                     ALLGPEQREPASVRADGVVLATGGYEKVWPFPGWTLPGVITAGGAQAMLKGGLTLPGRT
                     VVVAGTGPLLLPVATGLAAAGARVAALVESADPTTLVRRSAHPRNAVRGARALAAHPGK
                     LAEAGGYAAQLLWHRIPVLRRRAVVEAHGRDRLESVTVAVLGPDGRPVPGTAQRLDCDT
                     LAVGHGLLPHTDLADGLGCRLDGAGVHVDDEQRTDVPGVWAAGEATGIGGAALSLAEGH
                     IAGRSAAARLNGTAPDPRSWAPAARSRTRLRAFFAELDRAYAAPVRWAENVPDATVVCR
                     CEEVTAGAVREAVGSLGAGDLRTVKLLTRAGMGWCQGRMCEPGVAGVAGCDLTPGRRPL
                     ARPVPLGVLAAPPPPDAGTSPCPGTSP"
     misc_feature    7999..8009
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            8041..8946
                     /locus_tag="BM536_RS03900"
                     /old_locus_tag="BM536_003880"
     CDS             8041..8946
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069839.1"
                     /locus_tag="BM536_RS03900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003880"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_073497653.1"
                     /transl_table=11
                     /translation="MTTPHMTTPRPWHGVLVATALPLRDDLSVDLDRYAEHCAWLVANG
                     CDGVVPNGSLGEYQVLTPEERAAVVRTAVAAIGGERVMPGVAAYGSAEARRWAEQAREA
                     GCGAVMLLPPNAYRADEGAVVAHYAEVAQAGLPVVAYNNPIDTKVDLVPELLARLHGEG
                     LIHGVKEFSGDVRRAYRIAELAPELALLIGADDVLLELAVAGAKGWVAGYPNALPRASV
                     NLYRAAVAGDLTTALPLYRQLHPLLRWDSRVEFVQAIKVSMDVVGRYGGPCRPPRVPLP
                     PEQGAAVRAATEKAVAAGLA"
     gene            8971..9971
                     /locus_tag="BM536_RS03905"
                     /old_locus_tag="BM536_003885"
                     /pseudo=""
     CDS             8971..9971
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358096.1"
                     /locus_tag="BM536_RS03905"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003885"
                     /product="proline racemase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRSTLVLHAVDSHTEGMPTRVITGGVGTIPGATMNERRLYLREHR
                     DEVRQLLMNEPRGHSAMSGAVLQPPTRADCDWGVVYIEVSGYLPMCGHGTIGVATVLVE
                     TGMVEVVEPVTTIRLDTPAGLVVAEVAVRDGAATAVTLHNVPSFAVALDREITLPDGRT
                     VTYDLAYGGNFYAILPLEEFGLPFDRSRKDDILRAGLSLMEAINAEGEPVHPQDPSIRG
                     CHHVHLYAPGATARHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGELPLHTEFVNES
                     FIGTRFTGRLLGRAEVAGVPAVLPSFTAAHGSPARPSTCSTRRTRSRPGSRS"
     misc_feature    complement(10117..10127)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     misc_feature    complement(10141..10151)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            10176..10874
                     /locus_tag="BM536_RS03910"
                     /old_locus_tag="BM536_003890"
     CDS             10176..10874
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069837.1"
                     /locus_tag="BM536_RS03910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003890"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_094102520.1"
                     /transl_table=11
                     /translation="MAAPRSISPSPAAPALPVLGGRRSSYRERVADALRAALIAGELRP
                     GQVYSAPTLAARFGVSATPVREAMLDLAKEGLVDAVPNKGFRVTDVSDRQLDEYTHVRA
                     LIEIPTVVALATTADPVSLEALRPAAREIVTAAVAGDLIAYVEADTRFHLGLLALAGNS
                     HLVEVVRDLRGRARLYGLTALSASGRLLASAEEHLELLDALLARDERAVRTVMTRHLGH
                     VRGLWASADA"
     gene            11000..12286
                     /locus_tag="BM536_RS03915"
                     /old_locus_tag="BM536_003895"
     CDS             11000..12286
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136892.1"
                     /locus_tag="BM536_RS03915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003895"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_073497670.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.5e-11, bitscore:
                     38.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FMO-like (E-value: 2.6e-77, bitscore:
                     255.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVCVIGAGLSGLAAARALETAGVDFVCLERSGDVGGIWRRPEAG
                     ERGPGYLSLHLNTTKGLTGYADYPMPASYPVYPRHSQVASYLRAFAEWADVLDHIELGT
                     SVESVRQETDGSWTVVAVDAGGTRGARSFSHVVVASGHNTEPSLPALPPGSDTFTGTIL
                     HALDYRDGSDYAGQRVVVVGLGASAVDIAADLSRYAATTLLSVRRGLHILPKQLFGIPL
                     DEVAEAPWWTSMSLAEQRRFIEQALLVARGRLSDYGLPEPDHPVFASAVTISDEILTRI
                     RHGGVVPKPAIASLDRDRVVFTDGSSARADAIVHCTGYRMAFPFLPSGCPIGDQGSVEL
                     YKRVVAPGHAGLYFVGLVRPHGSITRLVEAQSRWIARIVSGAAALPEPEVMRKEVATYL
                     SGIAGQYGQAEGASIQVNVAPYLQELRDV"
     gene            complement(12484..13635)
                     /locus_tag="BM536_RS03920"
                     /old_locus_tag="BM536_003900"
     CDS             complement(12484..13635)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388029.1"
                     /locus_tag="BM536_RS03920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003900"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_073497656.1"
                     /sec_met_domain="indole_PTase (E-value: 3.8e-135, bitscore:
                     445.3, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAARPGGPRRSGTETLGGHTSRQLRNLCEIVGLTAHDGEVYART
                     LTEMLGAAAERPLDLPPPNPTFLSDDHTPVEFSLSFVPGAAPALRVLLEPGCAAGGLAR
                     NGRLGLRAVRETAARWGFSTDRLDELEDLFLPPSPEGPLALWCALELRPGGVPKVKVYL
                     NPAAGGQKRAAATVGEALRRLGHRDAFAALPPHDRHLFFALDLGDWAEPRVKVYLAHQD
                     LSAAEAGALSRMEGGPLAAESEEFFRIASGQHGDEDGGGTASAPVVRRPVQSCHAFTET
                     ASGMPSGFTLYVPVRDYARHDGDALTRATALLRRYGQDPAPLLGAVSAVTDRSPEDGVG
                     LVAYLALAHQQGQPPRVTAYVSSEAYEVRPPAGLLPAEPATVR"
     misc_feature    complement(13739..13753)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.1"
                     /tool="antismash"
     misc_feature    complement(13820..13835)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            complement(13858..15198)
                     /locus_tag="BM536_RS03925"
                     /old_locus_tag="BM536_003905"
     CDS             complement(13858..15198)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125674.1"
                     /locus_tag="BM536_RS03925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003905"
                     /product="cytochrome P450"
                     /protein_id="WP_073497658.1"
                     /transl_table=11
                     /translation="MDQPTAPVPPPGCPAHNSGARVPLHGPEFAADPQAYYSYLRHYGP
                     TAPVELAPGVEATLVTDYATALQLLQDSGSFRKDARRWRHFNEGKISPDSPVAPVLAYR
                     PNCMFSDGAEHLRLRQAVTDSMARIDTRKLSHSTEQVSNYLISQFASRGSADLLGDYAK
                     QLPLFVFNELFGCPPDIGDRVVYGITGMFDGINPARAMEVLFGAVGELVALKRVKPGED
                     VTSWMMAHQAALTDEEMVHQLALLLVGGNEPLRNLIGNTLHRLLTHDAYANQGGLIDEA
                     IDDTLWENPPMQNLAPHYPAADMEFAGQQLQAGDLLLVSFAAANTGPALTAARQAGSNR
                     AHLAWSAGPHACPSKDPARQITVTALENLLNKLPDVELAVPEESLTWRPGPFNRGLIAL
                     PARFTAVTERKPAPEARTEAARPEQPQPGTRAERSGVWSQFLNWLTR"
     gene            complement(15207..15800)
                     /locus_tag="BM536_RS03930"
                     /old_locus_tag="BM536_003910"
     CDS             complement(15207..15800)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358089.1"
                     /locus_tag="BM536_RS03930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003910"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_073497659.1"
                     /transl_table=11
                     /translation="MVSGPSLDEQAYVREGASQTAVKILVVGHFAVGKTTFIGAISEIP
                     PLSTEETMTRAAEAVDDLKGVQGKTTTTVAMDFGRLTISDRVVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFAVIDLIEQYGLDYAIAVNHFDGSPLRDETALRDALD
                     LLDDTPVVTCDARDEQSSAEALITLVRHLQDRAH"
     gene            complement(15775..16152)
                     /locus_tag="BM536_RS03935"
                     /old_locus_tag="BM536_003915"
     CDS             complement(15775..16152)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="BM536_RS03935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003915"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_073497661.1"
                     /transl_table=11
                     /translation="MTGFDELEPQTPELVRPYVITKGRGLPDEEQLSLITLVTAVADRQ
                     QRPTRLSPEEQSLLELCSAGYLSVAEIAGHTQLPLGVVKILLAALTEGGYLITRPPVQR
                     APVADREILEEVLNGLRAKFG"
     misc_feature    complement(16111..16113)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16149..16550)
                     /locus_tag="BM536_RS03940"
                     /old_locus_tag="BM536_003920"
     CDS             complement(16149..16550)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="BM536_RS03940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003920"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_073497663.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDIGKDDADRV
                     AAAMSGVQSLSRSLAFFCEDAQQRWRQTLVEFDGGWVFLISAGEGAYLGVSASPDVDMA
                     DITFRMQQLVGQLGKALTTPPRENLGVRS"
     gene            complement(16547..17719)
                     /locus_tag="BM536_RS03945"
                     /old_locus_tag="BM536_003925"
     CDS             complement(16547..17719)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="BM536_RS03945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003925"
                     /product="ATP-binding protein"
                     /protein_id="WP_094102521.1"
                     /transl_table=11
                     /translation="MTDYIQNPVLWALLIVVLAAVALIVRQRRAARTLRQEFADLRARH
                     DELENGYAKSVEAAQERADEATKTVLKSAMRTLQGLAAEQQLIVSRLQKKYGESVILQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGRQRDVASVYDVVRSAQGRIRHYRRVEILSQVD
                     FGITSRAVEPVALALAEMLDNATSYSSPDTVVEINIRTVPKGICIVVDDAGVGMNDEER
                     ARAEKLLSSDRVSGVSRLGNPPQFGFAVIGVLAERFGFEVSVDSTSPYGGVRAVLLLPH
                     DLLTNAPEQKEPTPAAPAVAAPTRGGPEPGPAPSTTVDGLPKRRRKRPMAIVPGSAPTA
                     SAPSRSGAETAAIMGAFQRGTQSGRRATPADPAEQSSSTRGASSEGHEFS"
     misc_feature    complement(17618..17620)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17696..17714)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.58"
                     /tool="antismash"
     misc_feature    complement(17893..17910)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     misc_feature    complement(18043..18059)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     misc_feature    complement(18046..18055)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     tRNA            complement(18161..18245)
                     /anticodon=(pos:complement(173705..173707),aa:Leu,seq:gag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="BM536_RS03950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="BM536_003930"
                     /product="tRNA-Leu"
     gene            complement(18161..18245)
                     /locus_tag="BM536_RS03950"
                     /old_locus_tag="BM536_003930"
     gene            complement(18400..18912)
                     /locus_tag="BM536_RS03955"
                     /old_locus_tag="BM536_003935"
     CDS             complement(18400..18912)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073062.1"
                     /locus_tag="BM536_RS03955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003935"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_143650780.1"
                     /transl_table=11
                     /translation="MTATPTRRPSNCVLRASSDGPTARTGPLLGRAQSRPTGITAETLV
                     SHGVDGHEPAGLAVPADGAEPSQADATARPGVDRTTMVSLVDGPEDHGLVERRPSSYDR
                     RSDVVALTAPGEECLLQAERARRAAERARRAAEHHFLAPLSEEAATALLPALRTPVAEE
                     DPATGRP"
     gene            complement(18995..20535)
                     /locus_tag="BM536_RS03960"
                     /old_locus_tag="BM536_003940"
                     /pseudo=""
     CDS             complement(18995..20535)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004980893.1"
                     /locus_tag="BM536_RS03960"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003940"
                     /product="aldehyde dehydrogenase family protein"
                     /pseudo=""
                     /sec_met_domain="Aldedh (E-value: 2.7e-40, bitscore: 133.1,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASTLTLKSGTSWADAWRRCLTAAPEAFREDRVLNLWNGAWQADG
                     RTLPATSPVDGGPVTGPPRLDRATAHQAVRASLDQHRAWRHLPLTERRARVAATLDALA
                     AHRELLALLLVWEIGKPWRLAQADVDRAVDGVRWYVDGIEPMLAGRAPLDGPVSNIASW
                     NYPMSVLVHAVLVQALAGNAVIAKTPTDGGVACLTLACALAAREGIPVTLVSGSGGELS
                     DALVRAPEVGCVSFVAVATPAPPSPPP"
     assembly_gap    20636..20735
                     /estimated_length=100
                     /gap_type="within scaffold"
                     /linkage_evidence="align genus"
     gene            <20736..21993
                     /locus_tag="BM536_RS03965"
                     /old_locus_tag="BM536_003945"
     CDS             <20738..21993
                     /codon_start=2
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127426.1"
                     /locus_tag="BM536_RS03965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003945"
                     /product="polyketide synthase dehydratase domain-containing
                     protein"
                     /protein_id="WP_143650807.1"
                     /transl_table=11
                     /translation="RPPTRPARPWPADPASERVPEHTAAQLYDERWMFHGPAFQGVTDL
                     TAIGDRHVRGVITTPPAPGALLDNVGQLLGYWIMATRTARTVVFPVGMREMRFHGPHPA
                     PGTEVACLVRITSLTDTLLAADVQLTVDGTVWAELYGWQDRRFDNDPKTRPVERFPERN
                     TLSEARPGGWSLLHERWPDLASRELIMRNSLAGPERVRYAEHAPRGRRQWLLGRIAVKD
                     AVRQWLWDQGEGPVFPAELRVHNDEAGRPYVTGVHGRVLPPLDVSLAHCAEAGVAIVRP
                     HTPGPGPGIDIEEVTERTPQTVATALGPDELRLLRTLVSDGSDGSDGSDGSEGLWFTRF
                     WAAKEAVAKAEGTGFGGRPRDFAVLDATPAGDRLTVAGRLERAYTVHCAPAVNPPHLPD
                     RTYAVAWTTGPVEAKEYDR"
     gene            21990..22307
                     /locus_tag="BM536_RS03970"
                     /old_locus_tag="BM536_003950"
     CDS             21990..22307
                     /NRPS_PKS="Domain: PP-binding (20-76). E-value: 4.8e-11.
                     Score: 34.8. Matches aSDomain:
                     nrpspksdomains_BM536_RS03970_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127425.1"
                     /locus_tag="BM536_RS03970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003950"
                     /product="acyl carrier protein"
                     /protein_id="WP_073500033.1"
                     /sec_met_domain="PP-binding (E-value: 8.6e-09, bitscore:
                     30.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPHTSVTADERTVLADLTELLARLMEDEYGLDDIEIGPDTTFNR
                     DLELESIDLVTLAGLLQERYGDRVNFAEFLAGMEFDEIIELTVGRLVEYVVASLHAAEA
                     S"
     aSDomain        22050..22217
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM536_RS03970_PP-binding.1"
                     /evalue="4.80E-11"
                     /label="BM536_RS03970_PP-binding.1"
                     /locus_tag="BM536_RS03970"
                     /protein_end="76"
                     /protein_start="20"
                     /score="34.8"
                     /tool="antismash"
                     /translation="LLARLMEDEYGLDDIEIGPDTTFNRDLELESIDLVTLAGLLQERY
                     GDRVNFAEFLA"
     gene            22310..23122
                     /locus_tag="BM536_RS03975"
                     /old_locus_tag="BM536_003955"
     CDS             22310..23122
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (26-134). E-value:
                     1.4e-27. Score: 88.8. Matches aSDomain:
                     nrpspksdomains_BM536_RS03975_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127424.1"
                     /locus_tag="BM536_RS03975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BM536_003955"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_073500035.1"
                     /sec_met_domain="PF00561 (E-value: 5.7e-24, bitscore: 80.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8e-21, bitscore:
                     70.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMVDTGAVRLHVQRIGPRDGRPATATVVLVHGLLTDSLASYYFT
                     VAPAFAAAGLDVVMYDLRGHGRSARPADGYTLDDNVDDLEALLDRLAVTGPVHLVGNSY
                     GGTVAFGYAARHPERAASVTLIESEPATPAWAVKLGGILDRVVTQLAHNETDAIAWITA
                     HRGHNTARLARGAARLARDTTLGRDIPASRVLTEEQITAVRCPVLGVYGGDSDLAELAP
                     WLEASLPDCRTVVIPGHEHSVLVEAAPAVGGHVLALVREAERAGAEVR"
     aSDomain        22388..22711
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM536_RS03975_Abhydrolase_1.1"
                     /evalue="1.40E-27"
                     /label="BM536_RS03975_Abhydrolase_1.1"
                     /locus_tag="BM536_RS03975"
                     /protein_end="134"
                     /protein_start="26"
                     /score="88.8"
                     /tool="antismash"
                     /translation="TVVLVHGLLTDSLASYYFTVAPAFAAAGLDVVMYDLRGHGRSARP
                     ADGYTLDDNVDDLEALLDRLAVTGPVHLVGNSYGGTVAFGYAARHPERAASVTLIESEP
                     ATPA"
     CDS_motif       22589..22651
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM536_RS03975_0001"
                     /evalue="2.60E-06"
                     /label="NRPS-te1"
                     /locus_tag="BM536_RS03975"
                     /protein_end="114"
                     /protein_start="93"
                     /score="19.9"
                     /tool="antismash"
                     /translation="TGPVHLVGNSYGGTVAFGYAA"
ORIGIN
        1 cctcccggtg tctgcggatg atgtcggcgt agtggcgtcc ggtgcccttg gtcgtgcggg
       61 tctgggtgcg gtggtcgacg tggacccgcc tacgcgcggc cctcggtgcc gccctcctca
      121 ccccttcgac gtccccctcg acaccgcttt cgcgcccacg cccccggagg ggtgatcccc
      181 tccggggcgt acgggtccta cggcgcgccg tcagggcggg cgccggggcg taccccgtcg
      241 gccgggccgt gaaggtgccc cggccctggg tgcggctgcg cagtcgggtg gcgtagccga
      301 acagttccgc gagcggcacg gtggcggtca ccacggccgc gccgccgcgc acctcggaac
      361 cggtcacccg gccgcgccgg gcggcgaggt ccccgaggac tccgccgacg gcgtcctcgg
      421 ggacggtcac cgtgacttcc acgaccggtt ccagcaacac catcgtgcaa gcccgcaggg
      481 cctcgcggag gccgaggcgg cccgccgtgc ggaaggccat ctcggaggag tccttcacat
      541 gcgtcgcccc gtcggtcagc gtgacccgca ggccggtcac cgcgtgcccg ccgagggggc
      601 cctcggcgag ggcgtcccgg cagccggcct cgacggcacg gacgtactcc tgcgggaccc
      661 gtccgccgac cacggccgac cggaagtcga acccgtcctc caaaggctcc acatcgagca
      721 ccacatgcgc gaactgtccc gcgccgccgt cctgtttgac gtgccggaag accagtgcgg
      781 acacgccgcg gcccaccgtc tcgcggtagg tgacgcgtgg ccgaccgacg ttgacctcca
      841 gtccgagggt gcggcggatc ttctccaccg cgacctccag gtgcagttca cccatgcccg
      901 agagcacggt ctggccggtc tcggcgtcgg tgcgcaccgt gagcgacggg tcctcctcgg
      961 ccagccgggc gagggccgag gccagccggt cggcgtcggt agcgcgccgc ggctcgaccg
     1021 ccacggagac gacggggtcg gccaccccgg gcggttcgag gaccagcggg gcgtccggcg
     1081 cgcacagggt cgagccggcg cgggccgcct tcagcccgat cacggccacg atgtccccgg
     1141 cgaccgcccg ctccagctgg gcgtgccggt cgcctggacc cgcaggatcc ggccgacgcg
     1201 ctcgccgcgg ccggcgctcg cgtcccatac cgtgtctccc ttctcgatcg ttccggagta
     1261 cacccgcagg taggtgagcc tgccggtggg ggtggcgttg accttgaacg cgagggcggc
     1321 gaagggtgcg gcgggatcgg ccgaccgtcg ctcgtcgaca ccctcgtgca taccgcgtac
     1381 agccggcacg tccaggggcg acggcagata ggcgaccacg gcgtcgagca acggctcgat
     1441 accgcggttg cggtaggccg agccgcacag cacgaccaca ccgtcgccgg tgcgggtcag
     1501 gtcgcgcagc gccgcggcga gcgtctcggc cgagagcgtc tcccggtcgc agaactcctc
     1561 cagggcggcg ggatgccgtt ccgcaaccgc ttcctccagc agtcggcggc ggcgcagcgc
     1621 ctcctcgcgc agttcctcgg gcacgggtcc ctctacggcc gtctcggcgc cgtcgcccca
     1681 ggtcagcgcc cgcatccgga gcaggtcgac gacgccggtg aaggcgtcct cgatgccgat
     1741 cggaagctgg acgacgaggg ggacggggtg cagccgttcc cggatcgacg ccacggtcgt
     1801 gtcgaggtcg gcgcccgtcc ggtccagttt gttgacgaac gcgatcctcg gcacgccgtg
     1861 ccggtcggcc tgccgccaca cggactcgct ctgcggctcc acacccgcca cggcgtcgaa
     1921 caccgcgacc gccccgtcca gcacccgcag cgagcgctcc acctcgtcgg cgaagtcgac
     1981 gtgcccgggg gtgtcgatca ggttgacgcg gtggccgtcc cagtcgcagc tgacggccgc
     2041 ggcgaagatg gtgatcccac ggtcgcgctc ctgggggtcg aagtcggtga cggtcgtgcc
     2101 gtcgtggacc tcaccgcgct tgtgcgtggt cccggtggcg aagaggatcc gctccgtgac
     2161 ggtggtcttg cccgcgtcga cgtgggcgag gatgcccagg ttgcggacgg cggcgagatg
     2221 acggtcgagg ttgttgcgca cggcccgtgg cctttcgagg tgtgtctcgt gaaagggacg
     2281 gcgcgattgt ttgacgggac gtcagctgac cccgggcagc cggatgacag ctcggggaca
     2341 gccggcacga cgacagggct acggccacgg cgggaagtcg ccggggcagc tctgtcgtga
     2401 ggactggggt ctcgtcagac catccggtgc cggccgcgcc gcggacaccg gacggacgag
     2461 gacacgagga tcacctcgta gcgggaacgg gaagcggcgg cagcggtgcg gtcacgcatg
     2521 gccgggcccc cctcgttcgt cgcggtgcgg cgcggccctg ctcgtgggcg gcgctcgatg
     2581 gggcgagtgt agggaggaac ggacgtgcgc tgcacgtgct ttttcccacg ccccggagaa
     2641 acgccggtcg aagcggctct caggacgacc gcgccgacgt gtagaagtgc cgccgcaccc
     2701 tgcgcagcca cgcgtcggcg gccctctcgt cgggctgttc gggcagcacg ctgcgcgcct
     2761 cgtcgaacgc cgtctcgtac cggcgcaaca ggggaagggc ggtctcggga tcgtccgcca
     2821 cctgctcgcc gaaccggtgg aagctctccg ggtcgtcgac gcggatgctc aaccgtcctg
     2881 tggtgtacag ctcgtagccc tgtccgcaca gtcgcttgag gtgccgggcg tgcttggctg
     2941 tccgcttgcg cgtgtccgcg gagaaggagc cgtcgccacg ggcgagcagc ctgcggaact
     3001 gctgcgtggc gtagccgaga taggcgtccc ggacgcgccg ggcactcagg aacgtcgttc
     3061 ggatgcccac gagttcgtca ccgagcggtg tacggacctc gtacaggtcg gtgggcagcc
     3121 agacgagttc cgtgaccgtg gggttgccgc cgagcgcgag cctgcaccac ttcgcggcct
     3181 cgtgcagggt ccggtcgggt gccgtgctga cgtgggactc cttcggcggg tgcaggccgt
     3241 gcaactcctc ggtgagcgcg gcgaacaggc cgagccggtc cacgtcggag cctgcgtgcg
     3301 cgagcccgta cgcggtcgag ccgacgacgc ctgacagcag gatgttctgg acgctcatgg
     3361 actcccccgg tgctcatcgt ccgccgccgc gagaaggcgg cgggagtcgt catgatgccc
     3421 cggcgaccgg cccggccacc tcgcattttc cggccgcgag gttccgcagg gagccgacgc
     3481 aagcccgatc ggcgccccgc caccggctcg ctcggccggc cccgccagga ggtggccact
     3541 cggggccccc gccaccggtc tgaacggcgc cacgccagag gtcgccccga cagaggtccg
     3601 ctcggtgccc cgccaccggt ctacgccggc ccggccagag gtccgctcgg tgcctcgcca
     3661 ccggtccacc ccgcgccccg ccgcgccccg ccgcgcgagg agcatgccct cacccgtatg
     3721 acccgctgcg ctggtcgcct gggcgggccg gtggtgcggt gggagggaag tgggagccgc
     3781 ccgggcacac gtgcgccggg accccgttcc gtcctcagga ggcatacgtg atcacccctc
     3841 gcccgaccgg ccgcccgtcc cgcacggcga agaccgctgc cgccgcgccg gacctggcca
     3901 cgcccgtcac ggccgtatcc cgcacggagg gccgtcgggc ccgcgcggcg cacccggtcc
     3961 gcccggcccg tgtcctggcc gccgcgatgg ccaccggcgc gctgctcgcc acggcggcct
     4021 gctccagcgg ggacgacggc gcggcggccg actcggagac cgccgccgcg gtcgccgagc
     4081 ggcccgtcgc cgcgcagacc gccactccgg cccccaccat caccggatcg gtcagcgcca
     4141 cgccgacggc gaccgccacg tcgccgaccg gcaccgagtc gcccgccgcc cccctctcgg
     4201 agaccggcgc ccgcaacgcg ctgatcaccg cggcggacat cgaggacaac tgggtgcagg
     4261 tgaaggaccc gcaggcctgg cgcgacaagc tgctcatcgg cgaggtggac acggcccagt
     4321 tcgtcaccgg gaaggccgac gcggccgact gccagcgcct ggtcgacgcg ctctacgacg
     4381 agacgctgct cggccgtccg tccggggcgt cggcgctgaa cggcttccag gagggccagt
     4441 cccggctgct gtaccaggtc gccgcctatg agaaggcctc gctcgacaag tcgatggact
     4501 ggctgacgaa gctgcccgac acctgcgacc agttcaccct gaccggcggc gacagcggcg
     4561 aacgtaccgt ccaggtcgtc gaagcctcgc tgcccgagga gggcgacgcc cggcagggtc
     4621 tcaccgtgac cgtgaagggc accgcgaacg gcgacccggt gacgctcacc ctggacgtcg
     4681 ccgtcgtccg cgtcggtgac gacgcgatca ccatcaccaa cggcgggctc gacggcgccg
     4741 acgaggacac cacccggacc gccgtggaac agggcaccga acggctccgg gaagtccagg
     4801 cgggccggac gccgaccccg acgccgagca acctcgactg agcgatcgtc ccggctcagc
     4861 gagtcacctc cgcccgccac ctcgccacac cccatctcac cggagcgccc tgtcagccgg
     4921 cggccggcac cccgcccggc tgaacgggag cgctgggtcg gcctgttccc ctcgcctgga
     4981 ccatgtgaca tattactggc gtgaccaacc aatcgtcctg tgacgtcgtg gtcgtcggcg
     5041 ccggcatgat cggcgccgca tgcgcgctgt acgcggtgcg tgccggactg gacgtcgtcg
     5101 tggtggaccg gggtccggtg gcgggcggca cgacgggagc gggcgagggc aacctcctcg
     5161 tctccgacaa ggagccgggc ccggagctcg aactggccct cttgtcgtgc cggttgtggc
     5221 gcgggatcac cgaggaccga cggccggacg accaccgccc acccacccgg ggcaacggcc
     5281 tcggccccgg tctcactccc ggcctcggcc gtgccgtcga gtacgagccc aagggcggcc
     5341 tcgtcgtcgc ctccaccccc ggggcactca ccgccctcac ggaactggcg gtcggacagc
     5401 gcgccgccgg cgtcgagacg gtcgccgtcg atgccaatca actccgggag ctggagccgt
     5461 atttggcgcc cggcctggcg ggcggtgtcc tgtatcccca ggacgcccag gtcatgccca
     5521 ccctggccgc cgcgcacctg ctgcgcgcct cgggtgcccg ggtggagacc ggccgtacgg
     5581 tgaccggcgt gctgcgcggc cccgacgggg cggtgcgggg cgtacggacc gaccgcggcg
     5641 acctcctcgc gccctccgtg gtgaacgcgg ccgggacctg gggcgcggag gtcgccgcgc
     5701 tcgcgggcgt ctcgctgccg gtcctgccgc gccggggatt cgtcgtggtc accgagccgt
     5761 tgccgcgccg ggtacggcac aaggtgtact ccgccgacta tgtggccgac gtcgccagtg
     5821 actccgccac cctccagacc tcgccggtcg tcgagggaac ggcggccggg cccgtgctga
     5881 tcggcgcgag ccgggaacgg gtgggcttcg accggtcgtt ctccctgccc gtcgtcaggg
     5941 cgctggcggc gggggcgacc cgcctgttcc cgttcctgga gcacgtccgg gcgatgcgcg
     6001 cgtatgtcgg cttccgcccc tacctgcccg accatctgcc ggcgatcggt ccggacccgc
     6061 gtgcgccagg cctcttccac gcctgtgggc acgagggggc gggcatcggg ctggcgaccg
     6121 gcaccggcca cctgatcgcg cagacgctga ccggcaggac ccccgacctg gacctcaccc
     6181 cgttccgccc cgaccgcttc gccgaggagg ccgcgccgtg aaccccctgg acttggtcgg
     6241 ggcccgtccc ggcgcgccgt tcaccgtcac gttcgacggc cgggagatcg aggtgctgcc
     6301 ggggcagacg atcgccgccg cgctctggtc ggcgggcgtc gtcgcctggc gcaccacccg
     6361 cgaaggcgcc cgcccgcgcg gggtgttctg cgggatcggc gtctgcttcg actgcctggt
     6421 gaccgtggac ggccgccccg gccggcgcgc atgcctgacc cccgccacgc cgggcgccga
     6481 catcggtacg caggcaggga cgggccacga tgactgagcg gcggcaggtg ctcgcggtga
     6541 tcggtgcagg tccggcgggc ctcgccgccg ccctggcggc cgccgcgcga ggggtgcgcg
     6601 tggtgctcgt cgactccgcc gccgagccgg gcggacagtt ctaccggcag cccgccccgg
     6661 gcctcggcgc ccgccgcccg caggccctcc accaccagtg gcggacgtgg gagcgcctgc
     6721 gcgacgggct ggccacccac ctcgcggccg gacgtgtctc ctgtctgagt gaccatcacg
     6781 tgtggtgtgt cgaacgggac tcgggccgtt tcgccgtgca cgcactgctc ggccccgagc
     6841 agcgcgagcc ggcgtcggtc cgtgccgacg gggtggtgct ggcgaccggc ggctacgaga
     6901 aggtgtggcc gttccccggc tggacgctgc ccggagtgat caccgcgggc ggcgcccagg
     6961 ccatgctgaa gggcgggctc acgctgcccg gccgcacggt ggtggtcgcc gggacgggcc
     7021 cgctgctgct ccccgtggcg accggcctcg ccgcggcggg cgcccgcgtc gcagcgctcg
     7081 tggagtcggc cgacccgacc actctcgtac gtcgatccgc gcaccctcga aacgccgtac
     7141 gcggcgcccg cgccctggcc gctcaccccg gcaagctcgc cgaggccggg ggctacgcgg
     7201 cccaactcct gtggcacaga attccggtgc tgaggcgtcg ggcggtcgtc gaggcccacg
     7261 gccgggaccg gctggagtcc gtcaccgtcg ccgtactcgg cccggacggc cgcccggtgc
     7321 ccggcaccgc acagcgcctg gactgcgaca ccctcgccgt cggacacggc ctgttgccgc
     7381 acaccgacct cgcggacgga ctcggctgcc gcctcgacgg ggcgggggtg cacgtcgacg
     7441 acgaacagcg caccgacgtc cccggcgtgt gggcggccgg ggaggcgacg ggcatcggcg
     7501 gcgcggccct gtcgctcgcc gagggccaca tcgccggacg ctccgccgcc gcccgcctga
     7561 acggcaccgc acccgacccg cgctcctggg ccccggccgc ccggtcccgc acccggctgc
     7621 gggccttctt cgccgaactg gaccgggcgt acgcggcgcc cgtgcgatgg gcggagaacg
     7681 tgccggacgc gacggtggtg tgccgctgcg aggaggtcac ggcgggcgcc gtccgcgagg
     7741 ccgtcggctc gctgggcgcg ggcgacctgc gcaccgtgaa gctgctgacg cgggccggga
     7801 tgggctggtg ccagggccgg atgtgcgagc cgggtgtcgc gggggtcgcg ggttgtgacc
     7861 tcacccccgg ccgacggccg ctggcccgtc ccgtccccct cggagtcctg gccgcgccgc
     7921 ccccaccgga cgccggaacc agcccctgcc ccggaaccag cccctgaccc ggagccgcct
     7981 cccacccgcc acccgcagtg ctatgtcaca caccaattgc gtgagagagg cagacctcac
     8041 atgaccacac cccacatgac caccccccgc ccctggcatg gcgtcctcgt cgccaccgcc
     8101 ctccccctcc gcgacgacct ctccgtcgac ctcgaccgtt acgccgagca ctgcgcctgg
     8161 ctggtggcga acggctgcga cggcgtcgta ccgaacggct ccctcggcga ataccaggta
     8221 ctcacgcccg aggagcgggc cgccgtcgta cggaccgcgg tggcggcgat cggcggggag
     8281 cgcgtgatgc cgggggtcgc cgcgtacggc tcggccgagg cccgccgctg ggccgagcag
     8341 gcgcgggagg cgggctgcgg tgcggtgatg ctgctgccgc ccaacgccta ccgcgccgac
     8401 gagggcgcgg tcgtggcgca ctacgcggag gtcgcccagg cgggcctgcc ggtggtggcg
     8461 tacaacaacc ccatcgacac caaggtcgac ctggtgcccg aactgctggc ccggctgcac
     8521 ggcgagggcc tcatccacgg cgtcaaggag ttctcgggtg acgtacgccg cgcctaccgg
     8581 atcgccgaac tggcgccgga actggccctg ttgatcggtg cggacgacgt gctgctggag
     8641 ctggcggtgg caggcgccaa gggatgggtg gcgggctacc ccaacgcgct gccccgcgcc
     8701 tcggtgaacc tctaccgggc cgccgtcgcg ggggacctca ccaccgcgct gccgctgtac
     8761 cggcagttgc acccgctgct gcgctgggac tcgcgtgtcg agttcgtcca ggccatcaaa
     8821 gtgtcgatgg acgtcgtcgg ccggtacggc ggaccctgcc ggccgccgcg cgtaccgctg
     8881 cctcccgagc agggagctgc cgtccgcgcg gccaccgaga aggccgtcgc cgcgggcctg
     8941 gcgtaacccc accgcccgga aagggacttc atgcgcagca cactcgtcct gcacgccgtc
     9001 gactcgcaca ccgagggcat gcccacccgg gtgatcaccg gcggggtcgg caccatcccc
     9061 ggcgcgacga tgaacgaacg gcggttgtac ctccgtgaac accgcgatga ggtacggcag
     9121 ttgctgatga acgagccgcg tggtcactcg gcgatgagcg gcgcggtcct ccagccgccg
     9181 acccgggcgg actgcgactg gggggtcgtc tacatcgagg tctccggcta tctgccgatg
     9241 tgcgggcacg gcacgatcgg ggtggcgacc gtgctggtgg agaccggcat ggtcgaggtc
     9301 gtcgaaccgg tcaccaccat ccggctggac accccggccg ggctcgtcgt cgccgaggtc
     9361 gcggtacggg acggcgcggc cacggcggtg acattgcaca acgtcccgtc cttcgccgtg
     9421 gcccttgacc gcgagatcac cctgcccgac ggccgaacgg tgacgtacga cctggcgtac
     9481 ggcgggaact tctacgccat cctgccgctg gaggagttcg ggctgccctt cgaccggtcc
     9541 cgcaaggacg acatcctgcg ggccgggctg tccctcatgg aggcgatcaa cgccgagggg
     9601 gagccggtgc atccacagga cccgtccatc cgcggctgcc accacgtcca tctgtacgcc
     9661 cccggcgcca ccgcccgtca ctcgcggcac gcgatggcca tccacccggg ctggttcgac
     9721 cgctcgccct gcggtacggg gacgagcgcc cgcatggcgc aattgcacgc acgcggtgaa
     9781 ctgcccctgc acaccgagtt cgtgaacgag tccttcatcg gcacccgctt caccggccgg
     9841 ctcctcggcc gggcggaggt cgccggggtg ccggccgtgc tgcccagttt cacggccgcg
     9901 catgggtcac cggcacggcc cagtacctgc tcgacccgac ggacccgttc ccggccgggt
     9961 tcacgctctg accaccggtg tccaccaccg gccgggggtt cacgctccga cctccggcat
    10021 ccaccaccgg ccgggttcac gccccgacct ccggcatcca ccgccggccg cgcggccgtc
    10081 cgtacgccgg gagagcgccg tggatactga tggcacgtga catggcacag tccatgccga
    10141 gtgagatggc accgcccgtt ccgaggagat cccgcatggc cgccccgcgc agcatcagcc
    10201 cctcccccgc cgcgcccgcg ctgcccgtgc tgggcgggcg gcggagcagc taccgcgagc
    10261 gggtcgccga cgcgctgcgg gccgcgctga tcgcgggtga actgcggccc ggccaggtgt
    10321 actcggcgcc cacgctggcc gcccgcttcg gcgtctcggc gaccccggtg cgcgaggcga
    10381 tgctggacct cgcgaaggag gggctggtcg acgcggtccc caacaagggc ttccgcgtca
    10441 ccgacgtctc cgaccggcag ctcgacgagt acacccatgt ccgcgcgctc atcgagatcc
    10501 cgacggtggt ggcgctggcg acgaccgccg acccggtgtc gctggaggcg ctgcgtccgg
    10561 ccgcccggga gatcgtcacc gccgccgtgg cgggcgacct gatcgcctac gtcgaggccg
    10621 acacccgctt ccacctgggc ctcctagccc tggcgggcaa ctcccacctg gtcgaggtgg
    10681 tccgcgatct acgcggccgt gcccgcctct acgggctcac cgccctgtcc gcctccggcc
    10741 ggctgctggc gtccgccgag gagcacctgg aactcctcga cgccctgctg gcccgcgacg
    10801 agcgggcggt gcgcacggtg atgacccggc acctcgggca cgtacggggg ctgtgggcgt
    10861 ccgccgacgc gtagccggac gggccggccc cctgtcccac atgtgacctg tgtgatcttt
    10921 gtcgctggtt gcgggaagta cccgatgggc aggcactgcg cgtgtccgta gaggtcgtgt
    10981 ctttcctgtg ggggaatccg tgagtgtgtg tgtgatcggt gcgggcctgt cggggctggc
    11041 cgctgcacgg gccctcgaaa cggcgggtgt cgacttcgtg tgcctggaga ggtcgggcga
    11101 cgtgggcggc atctggcgcc gccccgaggc cggtgagcgg gggccgggtt acctgtcgct
    11161 gcacctcaac acgaccaagg ggctgacggg ttacgccgac tacccgatgc ccgcctccta
    11221 cccggtctac ccacggcaca gccaggtcgc ctcctacctg cgtgcgttcg ccgaatgggc
    11281 cgacgtcctg gaccacatcg agctggggac gtccgtcgag tcggtgcggc aggagaccga
    11341 cggttcgtgg acggtcgtcg ccgtggacgc ggggggcaca cgcggcgcgc ggagcttctc
    11401 gcatgtcgtc gtcgcctcgg ggcacaacac cgagccgtcc ctgcccgcgc tgcctccggg
    11461 ctcggacacc ttcaccggaa cgattctgca cgccttggac taccgcgacg gcagtgacta
    11521 cgccggtcag cgggtggtcg tcgtcgggct cggcgcgtcg gcggtggaca tcgcggcgga
    11581 cctgtcccgg tacgcggcga ccaccctgct ctcggtgcgc cggggcctgc acatcctgcc
    11641 caagcagttg ttcggcatcc cgctcgacga ggtcgccgag gcgccgtggt ggacgagcat
    11701 gtcgctggcg gagcagcgcc gtttcatcga gcaggccctc ctcgtggccc gcgggaggct
    11761 ctcggactac gggctgcccg agccggacca cccggtgttc gcctcggccg tgaccatctc
    11821 ggacgagatc ctcacccgca tccggcacgg cggggtcgtc cccaagcccg cgatcgcctc
    11881 gctcgaccgc gaccgggtgg tcttcaccga cgggtcgtcc gcgcgggccg acgcgatcgt
    11941 gcactgcacc ggctaccgca tggcgttccc gttcctgccg tccggctgcc cgatcgggga
    12001 tcagggctcg gtcgagctgt acaagcgggt cgtcgcgccc ggccatgccg gcctgtactt
    12061 cgtgggcctg gtccgcccgc acggctccat cacgcggctc gtggaggcgc agtcccgctg
    12121 gatcgcgcgg atcgtgtcgg gcgcggcggc tctgcccgag ccggaggtca tgcgcaagga
    12181 ggtcgccacc tacctgagcg gcatcgcggg ccagtacggg caggcggagg gcgcctcgat
    12241 ccaggtgaac gtggcaccgt acctccagga actgcgggac gtatgacggt cggtgggtgg
    12301 gcgcgtcggc ctggggtcgg caggtggcgg gctcccccgt ggccggctcc ctcgtcgttc
    12361 cgtggccccc ggctcccccg gctcccccgg tccgcccgcg tcgccggccg tcgcggcgga
    12421 gagggagcgg ttcgacgtcg tcggcgtacg gctcccccgc gagatgtccc ccggcagcgc
    12481 ccgttaccgc acggtcgcgg gctcggcggg cagcaggccg gcgggcgggc gcacctcgta
    12541 cgcctcggag gagacgtacg ccgtcacccg gggcggctgc ccctgctggt gggcgagtgc
    12601 caggtaggcg accagtccca ccccgtcctc cgggctgcgg tcggtgaccg cggacacggc
    12661 gcccagcagc ggggccgggt cctgcccgta gcggcggagc agggcggtgg cacgggtgag
    12721 ggcgtcgccg tcgtgccgcg cgtagtcgcg gacggggacg tagagggtga agccgctggg
    12781 catgccggac gcggtctcgg tgaaggcgtg gcaggactgt acggggcgcc gcaccaccgg
    12841 tgccgaagcc gtgccgccgc cgtcctcgtc accgtgctga cctgaggcga tgcggaagaa
    12901 ctcctcgctc tccgcggcga ggggaccgcc ttccatccgg gacagggcgc cggcctcggc
    12961 ggccgacagg tcctggtggg cgaggtagac cttcacccgg ggctccgccc agtcgcccag
    13021 gtccagggcg aagaacaggt ggcggtcgtg cggcggcaga gcggcgaacg cgtcccggtg
    13081 gccgagccgc cgcagcgcct cacccaccgt ggcggcggca cgtttctgcc cgccggccgc
    13141 ggggttgagg tagaccttga ccttggggac gccgccggga cgcagttcca gcgcgcacca
    13201 cagggcgagg gggccctcgg gcgagggcgg gaggaacagg tcctccagtt cgtcgagccg
    13261 gtcggtggag aagccccagc gggccgccgt ctcgcggacg gcccgcagtc cgagacgccc
    13321 gttccgtgcc aggccgccgg ccgcgcaacc cggttcgagc agcacccgca gggcgggcgc
    13381 ggcaccgggc acgaaggaga gcgagaactc caccggggtg tggtcgtcgg agaggaacgt
    13441 cgggttcggg ggcggcaggt cgagcggccg ctcggcggcg gcacccagca tctcggtgag
    13501 ggtacgcgcg tagacctcgc cgtcatgggc ggtgagtccc acgatctcgc acaggttgcg
    13561 cagttggcgg ctcgtgtggc cgccgagcgt ttccgttccg gagcgtctcg gcccgccggg
    13621 ccgggccgcc gtcaccggct ctcccgccac gggccggcgc cgacaaggag atacccgccg
    13681 gcgagggcgg gtatctcgag gctcaacgct gcgggatgtg gagggggaac ggtgtcggtg
    13741 gacatgtggt ccacggcaac tcctcgggct cgtgggatat gcgggttacc gcatggctca
    13801 ctacccctga ggttgaaccg tcatacagaa gtgaagagtt ggccggtgtt gtgtgaatca
    13861 cctcgtgagc cagttgagga actggctcca cacacccgag cgttcggcgc gggtgcccgg
    13921 ctggggctgc tccgggcggg cggcctcggt gcgcgcctcg ggggcgggct tgcgctcggt
    13981 caccgcggtg aaccgggcgg gcagcgcgat gagcccccgg ttgaaggggc cggggcgcca
    14041 ggtcaggctc tcctcgggga cggcgagttc gacgtcggga agcttgttga ggaggttctc
    14101 cagggccgtc acggtgatct gccgggccgg gtccttggac gggcaggcgt gcgggccggc
    14161 gctccaggcc aggtgggcgc ggttgctgcc ggcctgccgg gcggccgtca acgcggggcc
    14221 ggtgttggcg gcggcgaaac tgaccaggag caggtctccc gcctggagct gctgtccggc
    14281 gaactccatg tcggcggccg ggtagtgcgg ggcgaggttc tgcatgggcg ggttctccca
    14341 cagcgtgtcg tcgatcgcct cgtcgatcag accgccctgg ttggcgtacg cgtcgtgggt
    14401 gaggagccgg tgcagggtgt tgccgatcag gttgcgcagc ggctcgttgc ctcccaccag
    14461 caggagggcc agctggtgga ccatctcctc gtcggtgagc gccgcctggt gcgccatcat
    14521 ccaggaggtg acgtcctcgc cgggcttgac ccgcttgagc gcgacgagtt cgccgacggc
    14581 gccgaacagc acctccatcg cacgggcggg gttgatgccg tcgaacatgc cggtgatgcc
    14641 gtagacgaca cggtcgccga tgtccggggg gcagccgaag agttcgttga acacgaacag
    14701 cgggagctgc ttggcgtagt cgccgagcag gtcggccgag ccgcgcgaag cgaactggga
    14761 gatgaggtag ttggagacct gctcggtgct gtggctcagc ttgcgcgtgt cgatgcgggc
    14821 catgctgtcc gtgacggcct ggcgcagcct caggtgctcg gcgccgtcgc tgaacatgca
    14881 gttgggccgg taggccagca cgggggcgac ggggctgtcg ggggagatct tgccctcgtt
    14941 gaagtgccgc cagcggcgcg cgtccttgcg gaacgagccg gagtcctgca ggagttgcag
    15001 ggcggtggcg tagtcggtga caagggtggc ctcgacgccg ggggcgagtt cgaccggggc
    15061 ggtcggcccg tagtggcgca gatagctgta gtaggcctgc gggtcagccg cgaactcggg
    15121 gccgtggagc ggcactcgcg cgccgctgtt gtgcgccggg cacccgggcg ggggcaccgg
    15181 agcggtgggt tggtccattt ctgctcctag tgggcacggt cctgcaagtg gcggacgaga
    15241 gtgatgagcg cttcggccga cgactgctcg tcgcgcgcgt cgcaggtgac gacgggggtg
    15301 tcgtcgagca ggtccagcgc gtcacgcagg gcggtctcgt cccgcagggg ggagccgtcg
    15361 aagtggttga cggcgatggc gtagtcgagc ccgtactgct cgatcaggtc gatcacggcg
    15421 aacgagtccg cgagccgttc ggggtcgacg aggaccaggg cgccgagcgc gccgcgggcc
    15481 atgtcctccc acatctgcac gaaccgctgc tggccgggcg tcccgaacag gtacagcacg
    15541 acccggtcgc tgatggtcag gcgcccgaag tccatggcga ccgtggtggt ggtcttgccc
    15601 tggaccccct tgaggtcgtc gacggcctcc gcggcccgcg tcatcgtctc ctcggtggac
    15661 agcgggggga tctcggagat cgccccgatg aacgtggtct tgcccaccgc gaagtggccg
    15721 acgacgagga tcttcacggc cgtctgcgac gcgccctcac ggacgtacgc ctgttcatcc
    15781 aaacttggcc ctgagaccat tcagcacctc ctccaggatc tcccggtcgg cgacaggcgc
    15841 ccgctgcacc ggcgggcggg tgatgaggta gccgccctcg gtgagcgcgg cgaggaggat
    15901 cttcaccacg ccgaggggca gttgggtgtg ccccgcgatc tcggcgaccg acaggtagcc
    15961 ggccgagcac agctcgagca ggctctgctc ctccggggac agccgggtcg gccgctgctg
    16021 gcggtcggcg accgccgtca ccagagtgat gagggagagc tgctcctcgt cgggcagacc
    16081 gcgtcctttg gtgatgacgt acggacgaac taactccggt gtctggggct ccagttcgtc
    16141 gaaaccggtc atgaccgcac gccgaggttc tcgcgcggcg gtgtcgtcag ggccttgccg
    16201 agctggccga cgagctgctg catccggaac gtgatgtccg ccatgtcgac atcgggcgag
    16261 gcggagacgc cgaggtaggc gccctcgccg gcggagatga ggaagaccca gccgccgtcg
    16321 aactcgacca gtgtctgccg ccaccgctgc tgggcgtcct cgcagaagaa ggccagggag
    16381 cggctgagcg actggacccc gctcatggcg gcggccacgc ggtccgcatc gtccttcccg
    16441 atgtcctgcg ttcgggccat caacaggccg tcggcggata tcaggacggc gtgcagggcc
    16501 ccgggaatct ccagggcgct gtcaagcatc catgacagat cgtcgttcac gagaactcat
    16561 gcccttcgct gcttgcgcca cgtgtactgc tggactgttc cgcggggtcc gcaggggtgg
    16621 cccgccggcc cgactgggtg cctcgctgga aggcgcccat gatcgccgcg gtctccgcac
    16681 ccgagcggga gggcgcggag gcggtcgggg cactgccggg cacgatggcc atcggccgtt
    16741 tgcggcgccg cttgggcagg ccgtcgacgg tggtgctcgg ggccgggccg ggctcgggac
    16801 cgccgcgggt gggtgcggcg acggcgggag cggccggcgt cggttccttc tgctcgggag
    16861 cgttggtgag caggtcgtgc ggcaggagaa ggaccgcgcg tacgccgccg tagggcgacg
    16921 tggagtccac cgacacctcg aagccgaagc gctcggcgag gacaccgatc accgcgaacc
    16981 cgaactgcgg cgggttgccg agccgggaga cgcccgagac gcggtcgctg gagaggagtt
    17041 tctccgcgcg ggcccgctcc tcgtcgttca tgccgacacc ggcgtcgtcc acgacgatac
    17101 agataccctt gggcacggta cgaatgttga tttcgacaac cgtgtccggg ctggaatagc
    17161 tggtcgcgtt gtcaagcatt tcggcgaggg ccagtgcgac cggttccacc gcacggctgg
    17221 tgatgccgaa atcgacctgc gagagaattt ccacccgccg gtagtggcgg atcctgccct
    17281 gcgcgctgcg gaccacgtcg tagaccgacg ccacatcgcg ctgacgaccc agccagccgt
    17341 cacagaggac ggcgatggac tgggcccggc ggccgaactg ggagttcgtg tggtcgatct
    17401 ccagaaggtc ctggaggatg accgactcgc cgtatttctt ctggagccgg gagacaatca
    17461 actgctgttc cgcggcaagg ccctgaaggg tccgcatggc ggacttcagg actgttttcg
    17521 tagcctcgtc ggctctttcc tgagctgcct cgacggattt cgcgtacccg ttctccagct
    17581 cgtcgtgccg agccctgaga tctgcgaact cctgccttaa cgtccgcgcc gccctccgct
    17641 ggcgaacaat gagggcgacg gcggcgagta cgacgatgag gagagcccag agtaccgggt
    17701 tctgtatgta atcagtcata agactctctt caggcgactg acggccagat gctgaattcc
    17761 cgtcaatgcg ggtggaccgg cgggaccgcc cgcatcgggg ccaccgcccg gactgtcccc
    17821 gtagtcgggg atgtcgtcct tcacccatcc gcccgctcta caagcgccgt gatcgtatca
    17881 ccacacgatg cgatcacaga cagccaacat gggtgcccca gatgaacatt gacggttcgt
    17941 cagtgagcac gcggcgggcc gcctctgacg caaccgataa acgggcttcc gcggcattcg
    18001 ggaggcaatc gaggcgttcg gaacgatttc ccggaaaccg ccgggtaaag aaacgacaaa
    18061 acccgcaccc gggaatcccg gatgcgggtg acttctgcac ggaagctctc cgcgcacctt
    18121 cctcaccgag cgaaaaccgc tggatacgga gggtgataag tgtccgaggg gggacttgaa
    18181 cccccacgcc cgataaaggg cactagcacc tcaagctagc gcgtctgcca ttccgccacc
    18241 cggaccaggt gtctgccgcc gcgggtgttc ccccgtggcg acatgcacaa cgataccaag
    18301 ctttcggagt gcgtttcacc cgagtatccg ctggccgggg gcctgcgcgg gtgtccgggc
    18361 agggtccgac ccccggggtc acccggcgtg cgcggacagt cacgggcgtc cggtggcggg
    18421 atcctcctcc gcgaccggcg tgcgcagcgc cggcagcagg gccgtcgccg cttcttcgct
    18481 cagcggtgcg aggaagtggt gctccgccgc gcggcgcgcc cgctccgccg cgcggcgcgc
    18541 ccgctccgcc tggagcaggc actcctcgcc cggcgccgtc agcgcgacga cgtcgctgcg
    18601 gcggtcgtac gaactgggcc gccgctccac gagcccgtgg tcctccggtc cgtcgacgag
    18661 cgacaccatc gtggtgcggt cgactccggg ccgggcggtg gcgtcggcct gcgacggctc
    18721 cgccccgtcg gccggcacgg ccaggcccgc cggctcgtgc ccgtccaccc cgtgcgatac
    18781 gagcgtctcc gcggtgatcc cggtcggccg gctctgggcc cgtccgagca gggggcccgt
    18841 ccgagcagtg ggcccgtccg agctggcccg gaggacgcag ttcgaggggc ggcgggtggg
    18901 ggtcgcggtc acggaccacg cagggagggt aacggccggt gcacgagggt gactcggggc
    18961 ggcgcccgtc aggtgcgccg ccccgcggcc cgcttcaggg catcagctgg tagtcgggga
    19021 agttccccgg cagccgctcg tccgccggtc ctcgggtcac cgcccgcacg agcagtttac
    19081 cgcccacgaa cgcgccacgc caggaggccc cgaagccgcc gaacagttcg tcgcggtcgc
    19141 cgcgggagcg aggcgtgccg tggccgacct tgaaggcgcg gatctgcggg gccagtcgct
    19201 cgtaggtggc gcggtcgtcg gtggacaggg tggcgaccag cgccccgttg gaggcgttca
    19261 tggcggcgag cagttccgcc tccgtgtcga ccaggacgat ggtgtcgacc gggccgaagg
    19321 gttccgcgtg gtgcagtggc gacgagggcg gcgggttgag gagcgtgacc ggacggacgt
    19381 aggcggaggt gtcctggccg ggcaggaagc gcgcgtccgc caggtcgccg cggtacagcg
    19441 ggacggctcc ccggtcgacg gcctcggcga cctggtcgtg cagttccttg gccttggccg
    19501 cgttgatgac cggcccgaag tccaggcggg ggtaggggtc gtcgcgcttc tccacggcca
    19561 gggggtggcc gaccgtcaga gtgcgcaccg ccgggaggta cgccgcgagg aaggcgtcga
    19621 acagctcacg ctggacgacg aagcgcgggt acgccgtgca gcgctgcttg ccgtagtcga
    19681 agagcttggg gacgagggcc gcgagggtgt cccagtccga gtggttccag atgccccagg
    19741 tgttgagtcc ctcctgttcg aggatgtggc gtttgccgag gtccgtcacg gcggtggcga
    19801 cggcggcgcc ggtgtcgcga ccgcgacgaa ggagacgcag ccgacctcgg gcgcccgcac
    19861 cagcgcatcc gacagctcgc ccccgctgcc gctgacgagg gtgaccggga tgccctcgcg
    19921 ggcggcgagg gcgcaggcca gggtgagaca ggcgacgccg ccgtcggtcg gggtcttggc
    19981 gatgaccgcg ttgcccgcga gtgcttggac cagtaccgcg tgaacgagca cgctcatcgg
    20041 gtagttccag ctcgcgatgt tggacaccgg gccgtccagc ggggcccggc cggccagcat
    20101 cggctcgatg ccgtcgacgt accagcgcac cccgtcgacg gcccggtcga cgtccgcctg
    20161 cgcgagccgc cagggtttgc cgatctccca gacgagcagc agcgcgagga gttcgcggtg
    20221 ggcggcgagg gcgtcgaggg tggcggcgac gcgggcacgg cgttcggtca gcgggaggtg
    20281 gcgccaggcg cggtgctggt ccagggaggc gcggaccgcc tggtgggcgg tggcccggtc
    20341 caggcgcggc ggtccggtga cgggaccgcc gtccaccggg ctcgtggcgg gcagggtcct
    20401 gccgtcggcc tgccaggcgc cgttccagag gttgaggacg cggtcctcgc ggaaggcctc
    20461 gggggcggcg gtgaggcagc gccgccaggc gtcggcccag gaggtgccgg atttgagggt
    20521 gagggtggat gccatgcggt cactccgctc tcggtgcacg gtcgagagga aagggggagg
    20581 ggaaggaggg gaggggacga ggggaagggg aagggtgggc gcggcgccgg tccgtnnnnn
    20641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    20701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnccggc cgcccacccg gcccgcccgc
    20761 ccctggcccg ccgacccggc ctccgaacgc gtccccgagc acacggccgc ccagctctac
    20821 gacgagcgct ggatgttcca cggcccggcg tttcagggcg tcacggacct caccgcgatc
    20881 ggcgaccggc atgtccgggg cgtgatcacg acgccacccg cgcccggcgc cctgctggac
    20941 aacgtaggcc agctcctcgg ctactggatc atggcgaccc gcacggcccg gaccgtcgtg
    21001 ttcccggtcg gcatgcgcga gatgcgtttc cacgggccgc acccggcgcc cggcaccgag
    21061 gtggcgtgcc tggtgcggat cacctcgctc accgacaccc ttctggcggc cgacgtccag
    21121 ctgaccgtcg acggcacggt gtgggcggag ctgtacggct ggcaggaccg ccgcttcgac
    21181 aacgacccga agacccgtcc ggtcgagcgc ttcccggagc gcaacacgct ctccgaggcc
    21241 cggccgggcg gctggtcgct gctgcacgag cgctggcccg acctggcgtc ccgcgagctg
    21301 atcatgcgca actcgctggc cgggccggaa cgcgtccggt acgcggaaca cgccccgcgc
    21361 ggccgccggc agtggctgct gggccggatc gccgtcaagg acgccgtacg gcagtggctt
    21421 tgggaccagg gtgaggggcc cgtcttcccg gccgagctgc gggtgcacaa cgacgaggcg
    21481 ggccgaccgt acgtcaccgg ggtgcacggc cgggtcctgc cgccgctgga cgtgtcgctg
    21541 gcgcactgcg ccgaggcggg cgtcgcgatc gtgcggcccc acacccccgg gccgggtccc
    21601 ggcatcgaca tcgaggaggt caccgagcgc accccgcaga ccgtggccac cgccctgggc
    21661 ccggacgagc tgcggttgct gcggaccctg gtgtccgacg ggtccgacgg gtccgacggg
    21721 tccgacgggt ccgaggggct gtggttcacc cgcttctggg cggcgaagga ggccgtcgcg
    21781 aaggcggagg gcaccgggtt cggcgggcgg ccacgggact tcgccgtcct cgacgccacc
    21841 ccggccggcg accggctgac cgtcgcgggc cgtctggaac gcgcctacac cgtgcactgc
    21901 gccccggccg tcaacccgcc ccacctgccg gaccgcacct atgccgtggc ctggacgacg
    21961 ggtcccgtcg aagcgaagga gtacgaccga tgacccccca cacctccgtc accgccgacg
    22021 agcggaccgt cctcgccgac ctcaccgagc tgctcgcccg gctcatggag gacgagtacg
    22081 gcctcgacga catcgagatc ggcccggaca ccaccttcaa ccgtgacctg gaactggaga
    22141 gcatcgacct cgtcaccctg gccgggctgc tccaggagcg gtacggcgac cgggtcaact
    22201 tcgccgagtt cctggccggc atggagttcg acgagatcat cgagctgacc gtcggacgcc
    22261 tcgtcgagta cgtcgtggcg agcctgcacg ccgcggaggc gagctgacca tggccatggt
    22321 cgacaccggc gccgtccggt tgcacgtgca gaggatcggc ccccgcgacg gccggccggc
    22381 caccgccacc gtggtgctgg tgcacggcct gctcaccgac agcctggcca gctactactt
    22441 caccgtggcc cccgcgttcg ccgccgcggg cctggacgtc gtcatgtacg acctgcgcgg
    22501 ccacggccgc agcgcacgcc ccgccgacgg ttacaccctc gacgacaacg tcgacgacct
    22561 ggaggcgctc ctcgaccgcc tcgcggtgac cggaccggtg cacctggtcg gcaactccta
    22621 cggcgggacg gtcgcgttcg gctacgcggc ccggcatccc gagcgggccg cgagtgtcac
    22681 cctcatcgag tccgaaccgg ccacgcccgc ctgggcggtg aagctgggcg gcatcctgga
    22741 ccgggtggtg acgcagctcg cgcacaacga gaccgacgcc atcgcctgga tcaccgcgca
    22801 ccgcggccac aacaccgccc ggctggccag gggcgcggcc cgcctcgccc gcgacaccac
    22861 cctgggacgg gacatcccgg ccagccgggt actcaccgag gaacagatca cggcggtgcg
    22921 ctgcccggtg ctcggcgtgt acggcggcga ctccgacctc gccgaactgg cgccctggct
    22981 cgaggcgtcg ctgccggact gccggaccgt ggtgatcccg ggacacgagc actcggtgct
    23041 ggtggaggcg gccccggcgg tgggcggcca tgtactggcc ctggtgcgcg aggcggagcg
    23101 ggcgggggcg gaggtccgat gagccggttc ctgttcgtgg taccgccgtt gaccgggcac
    23161 atcaacccgg ccgtgggcgt ggcggccgaa ctcgcctgcc gcgggcaccg ggtggcgtgg
    23221 gcgtgctccg atcccgcgct ggtccggcgg ctcgcgggtg cgggtgccga ggtgttcgcg
    23281 tgcgccgggg cgccggaagg gacccggccg cccgagctgc gcgggcccga ggcgctgagg
    23341 ttcctgtggg agtggtatct gctgccgctc gccgaggcga tggcaccggg cgtgcgggcg
    23401 gccgtcgggg agttccggcc ggacgtggtg gtcgccgacc agcaggcctt cgcgggcgcg
    23461 ctggtcgcgg aacggctggg ggtgccgtgg gcgacctcgg cgaccacctc ggccgagttc
    23521 accgatccgc tggcgggact gccgaaggtg cgggagtggc tgcaggagcg gctcgcgctc
    23581 ctgcgcgcct cggtcggtga cccggcgggc cggaccgacc cgaggttctc gccgc
//
