LOCUS       NZ_CP017968            27009 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Paenibacillus polymyxa strain YC0573 chromosome, complete genome.
ACCESSION   NZ_CP017968
VERSION     NZ_CP017968.3
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6126117)
  AUTHORS   Liu,H., Hou,Q., Liu,K., Wang,C., Ding,Y. and Du,B.
  TITLE     Complete Genome Sequence of Paenibacillus polymyxa YC0573, a Plant
            Growth Promoting Rhizobacterium Isolated from Rhizosphere of Tobacco
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6126117)
  AUTHORS   Liu,H., Hou,Q., Liu,K., Wang,C., Ding,Y. and Du,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Department of Microbiology, Shandong
            Agricultural University, No. 61 Daizong Street, Taian, Shandong
            271018, China
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 6126117)
  AUTHORS   Liu,H., Hou,Q., Liu,K., Wang,C., Ding,Y. and Du,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-NOV-2016) Department of Microbiology, Shandong
            Agricultural University, No. 61 Daizong Street, Taian, Shandong
            271018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: canu v. 1.3
            Genome Coverage                   :: 140.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:02:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,505
            CDSs (total)                      :: 5,362
            Genes (coding)                    :: 5,219
            CDSs (with protein)               :: 5,219
            Genes (RNA)                       :: 143
            rRNAs                             :: 13, 12, 12 (5S, 16S, 23S)
            complete rRNAs                    :: 13, 12, 12 (5S, 16S, 23S)
            tRNAs                             :: 102
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 143
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 143
            Pseudo Genes (frameshifted)       :: 98 of 143
            Pseudo Genes (incomplete)         :: 53 of 143
            Pseudo Genes (internal stop)      :: 19 of 143
            Pseudo Genes (multiple problems)  :: 23 of 143
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:01:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1829009
            Orig. end                         :: 1856018
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017968.3.
            On Feb 23, 2018 this sequence version replaced NZ_CP017968.2.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27009
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="8"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27009
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27009
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17009]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17009
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            508..1689
                     /locus_tag="PPYC2_RS08280"
                     /old_locus_tag="PPYC2_18515"
     CDS             508..1689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820485.1"
                     /locus_tag="PPYC2_RS08280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18515"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_071558971.1"
                     /transl_table=11
                     /translation="MIKKNIGSYGQKNGSSHREDSRTRVFRQKATGVLMAGLIAGGLFS
                     GCGIKSAGETNPASGMKPGQQLTVIDTDAAQQQVTDELVVSSIDRLGDVYARSWLSDEE
                     LIVERKTQLWIHNVETDKERILTPGRKAPQLLAVVSPDQRHVFFTEGSTSSKYDIQGYI
                     LELSSGKVTSIGKLDMTNEVSWSDENDLITGTPDGKIQLIGLDGKAKELSFQDPNRSEL
                     MSHVEKVGNAIFYTGSDKQGYPVLNRFTLNHPQAVTIAEGAMSFAVSPDGKSIAIEKRK
                     WNTYEPARMIILDEQGKEKGIVGQGTLMSRGSWSSDGSKLAYSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSPSARFLSMYQNISEGGKQLNQSYIVEFKRK"
     gene            complement(1676..2707)
                     /locus_tag="PPYC2_RS08285"
                     /old_locus_tag="PPYC2_18510"
     CDS             complement(1676..2707)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014649242.1"
                     /locus_tag="PPYC2_RS08285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18510"
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_023987826.1"
                     /transl_table=11
                     /translation="MNTHPSFREVRESDQQVFPIAWYAVGWSKELKNKPLKKRLLGKDF
                     VLYRDDHRQVHAIHAYCPHRGADLSLGYCQNGHITCPYHAWSFDESGQCVDIPAHPGRA
                     IPEFAHTYAYPVIEKAGLLWVYPQAVGSKSEINSGLGTSTSPPPLEIFPELEDPSLILS
                     PYDSVWKAHLTRVVESVLDVAHLPIVHNKTIGKKSSTDIHIEFEADDNHIRVKNGKGLL
                     QYTFPQQWILTPAKEGRSKFINFVTFTPIEQELTAIYGLAGRNFARFVPGMSHIFSRYS
                     GKVLEEDRAVVESQHPRPIPEALRMEAHVPADGPQVRFRNRWYDFLVNDEPRVRLGPET
                     TSS"
     gene            complement(2923..4365)
                     /locus_tag="PPYC2_RS08290"
                     /old_locus_tag="PPYC2_18505"
     CDS             complement(2923..4365)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="PPYC2_RS08290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18505"
                     /product="SpoVR family protein"
                     /protein_id="WP_023987827.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIADGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLEGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATADRINSYEVEYGSEAVESFIDSVLAIQEHVDP
                     QIIKPRHLDKQRYMELKIREQKEPGKRQRPPGPYDDLWSLDTVKQHNPAETEGIKIRQF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGEETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKMFEVREFDSDTSFIRNYMTKKLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TLIEGKLALFSYDGKKHHRKFV"
     gene            complement(4362..5528)
                     /gene="yhbH"
                     /locus_tag="PPYC2_RS08295"
                     /old_locus_tag="PPYC2_18500"
     CDS             complement(4362..5528)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="PPYC2_RS08295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18500"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_023987828.1"
                     /transl_table=11
                     /translation="MPEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPNLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGKPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSSYNIYPFHFSDGDNLTSDNERCVKLIEELIKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKKDQFMYYVIKEKGEVYQALRTFFRKREGGSVG"
     gene            5693..6412
                     /locus_tag="PPYC2_RS08300"
                     /old_locus_tag="PPYC2_18495"
     CDS             5693..6412
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="PPYC2_RS08300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18495"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023987829.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTTVLKKEGFLQVKHAATGREALQVVM
                     ESHVDVIVLDVMLPDNDGFEVCRQMRLYTDAPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVVARMKARMKYRKVSTVAMKPTLRTLDFGYFRLELESGVLYVEDKQVDCPARE
                     WLLLVFLCKHPNRIFSVRQLYEAIWSEAFLGDEKTVVIHISRLRKKIEPDPKHPQFLIN
                     VRGLGYKMMSVKMEEQE"
     gene            6409..7479
                     /locus_tag="PPYC2_RS08305"
                     /old_locus_tag="PPYC2_18490"
     CDS             6409..7479
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="PPYC2_RS08305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18490"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_023987830.1"
                     /transl_table=11
                     /translation="MNSLVKMSFRFMKVTLCFVLAYVLCFVICTILYIFIKSIFGASQN
                     INIDLFWTGLGIVQSVVFIAAYGWYIGKPLVYVIKWIGNIATGEFQAPLSELELPEGKK
                     NQKNSYKPPYQLYKEVFEQMNILSAQLRSNEEERVELEKRKQQWVAGVSHDLKTPLSYI
                     EGYAAMLTAQEYDWSDEERRSFSMGISEKVTEMKQLIQDLNASMQLKEGPLPIQLEKED
                     IVEFLRSAVIDIANHPSAEQYEFSFTSMDAACIMPFDSKLLGRALQNFLINAIIHNPPG
                     THVSMEVSKANDKLHISIEDDGIGMNSNEYMQVSHSQGHGIPIAKSFIEAHNGTLHILS
                     GSKAGTRMEISLPLNI"
     misc_feature    complement(7569..7587)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.67"
                     /tool="antismash"
     gene            7624..8547
                     /locus_tag="PPYC2_RS08310"
                     /old_locus_tag="PPYC2_18485"
     CDS             7624..8547
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="PPYC2_RS08310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18485"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023987831.1"
                     /transl_table=11
                     /translation="MSEYVIHTQQLTRRFGKREFVKRINLQVPGQQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGEIEIFGKKLKDQRMEILKDIGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRRIHEVLDLVRLTKDAYRPVKGYSLGMRQRLGIAMALIANPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPGAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTA
                     KSKPQLFIETPDPVLAAGALIQHGWTAGAESIEQNEVVTPIVDRQQSSEMIKVLVEHNH
                     PIYRVTEKKKTLEEIFLELTGKERSL"
     gene            8544..9251
                     /locus_tag="PPYC2_RS08315"
                     /old_locus_tag="PPYC2_18480"
     CDS             8544..9251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="PPYC2_RS08315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18480"
                     /product="ABC transporter permease"
                     /protein_id="WP_023987832.1"
                     /transl_table=11
                     /translation="MILRVIKAEGLKLKKICWWIPLIQGCVLTGMTAVEWYLYFRQGPG
                     GVYAGFAVMFMFLSFVMLLGGTLLASIMAGTEHDTQTWKQLMAMPVPRSYIYLSKIVWI
                     VILQLGTALITVAGMSLIWVLYTNEPIPWRIMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKILPWSYPALSSPLMKEHMIWVIVALSAGVIFT
                     GLGTLQFTKHEFK"
     gene            9284..10000
                     /locus_tag="PPYC2_RS08320"
                     /old_locus_tag="PPYC2_18475"
     CDS             9284..10000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="PPYC2_RS08320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18475"
                     /product="ABC transporter permease"
                     /protein_id="WP_233903850.1"
                     /transl_table=11
                     /translation="METIKLQWIMVWILIILDAIINSLMGVLELNDLKQFFSPSWLTLY
                     TYSAQFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQQIYYAKYILLILILG
                     LDQLIFIVGYFVSGNIAGAPGEIPWSVVLSTGLGGWLGIFPLAALQLMLSIKIRNFGAS
                     LGMSICCVVPNIVITGFHSSIGAWFPFTIPYYIMMPQTATYAPRVEPYSLGLIVIFTFL
                     AYLYGGRKMFVNRDWL"
     gene            complement(10001..11362)
                     /locus_tag="PPYC2_RS08325"
                     /old_locus_tag="PPYC2_18470"
     CDS             complement(10001..11362)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="PPYC2_RS08325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18470"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_028542936.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-55, bitscore:
                     187.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDSFVIQQSDQVRARDISKKIALRLCEPESVYAAVHAEHNVSP
                     ETKYHPWGETSLSHGYPGNIHLLSQWRATDPSYDWNRAIHSNMAQIQSSLAKNGLHDLS
                     LYSGWAGIASSVREASNHGKYYSNFLQQIHQWMMPLTEQWLQSNTEKLSLHEGMPMQAF
                     DTISGASGIGRYILMNSTDPICTPLVEPILQFLTDLTHPIHIHNRYVPGWYSPQKFQFL
                     DRDKRNYPLGNFNCGMAHGIPGPLALLSVAYSAGIEVKGQYQAIETIAEWLLKYKYEDE
                     YGSYWPHIVPFEAETGSLRFDLERAREAWCYGTPGIACTLFLAGRALHNEELQKLAVKA
                     CVGAISYEIAKREMDSSALCHGLAGLLTISWRMWCHSKEPAFLPLIQQLTNCLLDRFQM
                     DSPLGYLDPEPRADGSLVWLTKAGMLEGVAGIAAALLSVSENKEIGWDYILMLS"
     gene            11561..11713
                     /locus_tag="PPYC2_RS08330"
                     /old_locus_tag="PPYC2_18465"
     CDS             11561..11713
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="PPYC2_RS08330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18465"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_023987834.1"
                     /sec_met_domain="TIGR03731 (E-value: 6e-05, bitscore: 21.2,
                     seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKNEVAPKGVQPASGIICTPSCATGTLNCQVSLT
                     FCKTC"
     CDS_motif       11561..11632
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKNEVAPKGVQPA"
                     /locus_tag="PPYC2_RS08330_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11633..11713
                     /prepeptide="core"
                     /locus_tag="PPYC2_RS08330_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="5.90"
                     /molecular_weight="2508.0"
                     /monoisotopic_mass="2506.2"
                     /core_sequence="SGIICTPSCATGTLNCQVSLTFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKNEVAPKGVQPA"
                     /leader_location="[11560:11632](+)"
                     /alternative_weights="2526.0"
                     /alternative_weights="2544.0"
                     /alternative_weights="2562.0"
     gene            11790..13052
                     /locus_tag="PPYC2_RS08335"
                     /old_locus_tag="PPYC2_18460"
     CDS             11790..13052
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="PPYC2_RS08335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18460"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_023987835.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-58, bitscore:
                     196.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEDLKGRSVEISKYIAQKLIDLSYTEKIVNHTNNLSPSRGNPPW
                     NPGSLADGIPGVFALLSEWGYLEPDQNWAEHVHSQLRYLDTNSLLLLPRISLYYGTTGV
                     AYGILLASNNRANYNKLISQLNKYIEVKWGDLPVIGTITEFSRQMDIINGLLGVGRYTL
                     EVAEDKTMCDLSRQLLDTITHFIPEYIHLSSREDSASIHLGLAHGITGILALLVTALQK
                     KIKVEGLHEAIKHIADFLLIQIQEDQYGWYWPVNSQASSMNKREKKVGMREIEGWCHGT
                     FGIAWTLFRAGIECSNEEWKKIAEKAMQSIFCLDDELLNALSPTFCHGLAGLLHMAHRF
                     YSLTGNIAALHFADQIALKLVNLYDEELPFGYRDLEGTTHVHNVGILQGATGIALSLLD
                     YGIGKEHPKYSGRWSELFLIS"
     gene            13103..13780
                     /locus_tag="PPYC2_RS08340"
                     /old_locus_tag="PPYC2_18455"
     CDS             13103..13780
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="PPYC2_RS08340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18455"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023987836.1"
                     /transl_table=11
                     /translation="MKQKFMVISSFRKIKHFFETLSTPENIRIMFYDSLYQALPEIDEQ
                     CIGVALNQDHITLEDLSYWHSIKEKFTVPFIFLSYHSDDQRQLDLLKQLFSMASSAYEM
                     EREQQAISLSPNVIFDPAGKVIWKQGHEHMLTMMEFRLLMYLLTAKECASTIDHIIDRV
                     WGVDAFTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYKLNIFPKNLEVVSCEETT
                     ALH"
     gene            13908..17009
                     /locus_tag="PPYC2_RS08345"
                     /old_locus_tag="PPYC2_18450"
     CDS             13908..17009
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370171.1"
                     /locus_tag="PPYC2_RS08345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18450"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_233903889.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-190, bitscore:
                     631.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.3e-15,
                     bitscore: 54.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.5e-53, bitscore:
                     179.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSQLTLEEITRRLKLISQEAVVQEAIALASPSLMQFLHYLNDGH
                     ALDDKGELQKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICGKTTDLDIGSYPKHLK
                     RARPDMEWIYKLIQKIEADPAIFNQLKVFLNKTVMIKGNRAKLPFRPKHGAAEADDSAE
                     IFNSIRLTDVVRMTFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSE
                     LRPPLMDHSPFHYIFEKIKKLDISDPWIHILHEIDTLLLQYNQCTIGEGEKVYRKLCDK
                     MLDIISVKTPVQVDVLLDKEVTLPKHVLDEVSLGAEVMCKLYASPKTDELAEYLNRFLE
                     KYGVYQEVPIHELFDEDWGLGIPEMYRSNEKKSMGMEAFKRNAVLFQWVSNAISNHEIE
                     LALTDEQLEQLMISDNYDTSPESMEIYYSIFAESPEKVDSGDYSLLLGASAGSNRAGKT
                     FGRFLDMFSEEFVQKFSEIYDHHRCFHPDALLSEMVFMPEQGKISNISLSKNLMAYEIV
                     SGTTSSKDEDHTLCIDDLVVGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPHIFRFLT
                     DITNKEIGTWSYFDWGPLEQSPFLPRLVYKKIIISAAQWKLSKASLNISESCESKEGEE
                     LFHVWRQQWNVPRYVYLTMGDNRLLLDLCNLFHIKELLHEVSKTREGQELLLTECLGNP
                     FHTPVQGTAGRYMGEFVFPLKKKKIKVKPSIPSSQNHIVSQNFITHTPSSIHRGIFPGG
                     EWLYLKLYGVKERETDLVGLSLGHLLKQPGFKDWSRKFYFLRYVDPEHHIRLRFQGEPD
                     KLWTAGLAQLNQWAAELREEGLITNMVIDTYHPELERYGGQTLMELAEQVFDVDSQWVI
                     AYMKGIRSNAFNLDIEIAAVINIIHYLSGFGLTIQEQVKWLEERIDCKPHMKAFRDVKK
                     TLITAVESNYEWIGQADTNTQVAFLALVEKRQTMIQQYAQAIILAKNNHELTNPSDDIL
                     GSIIHMHLNRLLGVNREREIKCMALAKHTVANLLHRKGVSYVTV"
     aSDomain        14301..14585
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PPYC2_RS08345_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-17"
                     /identifier="RREFam001.1"
                     /label="PPYC2_RS08345"
                     /locus_tag="PPYC2_RS08345"
                     /protein_end="226"
                     /protein_start="131"
                     /score="54.8"
                     /tool="antismash"
                     /translation="VFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRLTDVVRM
                     TFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSELRPP"
     misc_feature    complement(17257..17270)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 22.3"
                     /tool="antismash"
     misc_feature    complement(17305..17318)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.15"
                     /tool="antismash"
     gene            17416..18897
                     /locus_tag="PPYC2_RS08350"
                     /old_locus_tag="PPYC2_18445"
     CDS             17416..18897
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="PPYC2_RS08350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18445"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_233903890.1"
                     /transl_table=11
                     /translation="MLQRAQGEADFRPFEIFTQILAIISSVVTLFSTGAILIAWRWWAF
                     LFIFLIPCLSFYSFLRIGQREFNVHFQRAGRQRESWYLSFLVTRDNSFKEVKIFQLGDY
                     LRKRYKTILEGFYREDKVLAVRRSYTSLVFQIVNQGACAFIIFMAIQATYVGQILVGNL
                     VSLIQGITLTQSTSQSIVQGILSLCQNNLYIKQLFDFLDMPEEAKIQKTVQQLPLSTIH
                     SIEFRNVSFRYPNTEENAISNVSFKLHQGEKLAIVGRNGSGKSTIVKLLTHLYSDFEGE
                     ILINGHSIHELDKDSFREKIGVVFQDFVHYEMAVRDNIGFGNVASRENDEAIWTAIDKA
                     GITDLIVGLPDKMNTLLGKWFEDGQQLSGGQWQRIAIARAFMRNADIYVLDEPSSFLDP
                     HAEKEVFQKFDQLIHEKIGVFISHRLSSARMADTIILMEEGKIVEAGSHEHLMDIDGVY
                     AEMFRLQASSYLSQRERGFEEGDLSPSLVRTTGGA"
     gene            complement(18942..19265)
                     /locus_tag="PPYC2_RS08355"
                     /old_locus_tag="PPYC2_18440"
     CDS             complement(18942..19265)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003331885.1"
                     /locus_tag="PPYC2_RS08355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18440"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_023987839.1"
                     /transl_table=11
                     /translation="MNINPNVLYIIIGAMIVTAIPRIIPFVVLQRLALPKPVLQWLSYI
                     PICIFTALVMENLLVRTETSVTLNGQVLMAVLPTLVTALWSKNLLATVVVGIVSMAVIR
                     LLW"
     gene            complement(19262..19987)
                     /locus_tag="PPYC2_RS08360"
                     /old_locus_tag="PPYC2_18435"
     CDS             complement(19262..19987)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="PPYC2_RS08360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18435"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_023987840.1"
                     /transl_table=11
                     /translation="MSIASELSGTKHDSLSFLQGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIAFMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLWKNIGIGVLLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIASCVAGGVLG
                     NWISRPEAFGLDFALPAMFLALLISQLQSVQTSKLKHRLLLVLCMAVLMYLLAWWVPSH
                     IAVIIATMITATIGVLTDK"
     misc_feature    20007..20020
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     gene            20142..20303
                     /locus_tag="PPYC2_RS08365"
                     /old_locus_tag="PPYC2_18430"
     CDS             20142..20303
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PPYC2_RS08365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PPYC2_18430"
                     /product="hypothetical protein"
                     /protein_id="WP_155613661.1"
                     /transl_table=11
                     /translation="MYLPKRFGRVPVPDDLAAASHPKAVFKCTPDELFEMANGQELMMN
                     QSSSDVFI"
     gene            complement(20389..21596)
                     /locus_tag="PPYC2_RS08370"
                     /old_locus_tag="PPYC2_18425"
                     /pseudo=""
     CDS             complement(20389..21596)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017815673.1"
                     /locus_tag="PPYC2_RS08370"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18425"
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYTMQLATIFIGFIVFGISENIKGPAIPRIQFDFNLDEQQLGTLL
                     SLNALGYLIACSFTAVLVRKWGIKAVSIISFASMIISGVFIYLSHTYPFFASSYFLMYI
                     GNGMLEIALAILGARIFVKNTGTMMNLSHFFYGLSSTVAPLLATGVMSLTVFGHMLDWR
                     GMYLAMLSLCLLPIVAALLSTFPGDDLQHEDRTSLKTLTRDPALWMMVMILSFGVVSEL
                     AVGGWLVNFLEKAYSWSTVEASSMLSAFFLTFSLGRLLLGPLTDRMGFVLSTILFSAFS
                     AICTFAAIAGGERLAFLFAVSGAGIAMIYPTVMAFIARRYPKDSDTAITFVVTLMGIGS
                     VIGNYVIGWVIEGSR"
     gene            22040..22588
                     /locus_tag="PPYC2_RS08375"
                     /old_locus_tag="PPYC2_18420"
     CDS             22040..22588
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429618.1"
                     /locus_tag="PPYC2_RS08375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18420"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_023987843.1"
                     /transl_table=11
                     /translation="MDSMQHIIGSNLAQIRKTRGLSLDKVAELTGVSKGMLAQIEKGKS
                     NPTVTTLWKIANGLHVSFSTFLKEDPPQITKIRREDLHPVIDEDGNYFVYPVFPYHAEK
                     KFEVFTVSLKPGFTHQAEKHLGEETILMIRGEMYFEMQGQQLKLSAGDAVQFQVSDIHT
                     YRNDSDEDADFYVLIYYAD"
     gene            22689..23204
                     /locus_tag="PPYC2_RS08380"
                     /old_locus_tag="PPYC2_18415"
     CDS             22689..23204
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280639.1"
                     /locus_tag="PPYC2_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18415"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_013309488.1"
                     /transl_table=11
                     /translation="MESKYIRETYCFKTSRVFPNDINNHNTLFGGRLMSYIDDIASIAA
                     AKLCRTNTVTASTDSVDFLLPIHPSDSVTLEAFVTWTGRSSMEVFVKVIREGLMTGDRK
                     IAATAFLTFVALDENNRKVTVPQVIPETEEQLQLHQTAPSRAAIRRQRREESKQLASFL
                     TTDYPWEL"
     gene            complement(23313..24779)
                     /locus_tag="PPYC2_RS08385"
                     /old_locus_tag="PPYC2_18410"
     CDS             complement(23313..24779)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686791.1"
                     /locus_tag="PPYC2_RS08385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18410"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_025723966.1"
                     /transl_table=11
                     /translation="MKYDFARLLCIMLSILLTLSIFQMFSPKIASAASANVVNGIQFKD
                     TDGNVVHAHGGGMIKVDGYYYWFGENRNPNGTFKAVSAYRSSDLKNWEFRKNVLTSSSA
                     VELNVSNIERPKVIYNEKTRKYVLWMHKENGVNYNEARVAVASSDTVDGDYTYQGSFRP
                     LDHDSRDMTVYNDNGTAYLISATRVNADLNIYRLTPDFLQVESLVTTLWPGQYREAPAM
                     FKKGDVYFLITSGATGWNPNQAKYATASSIEGTWSNTINFGDGTTYGSQSAYVIPVEGA
                     QTTSYLYLGDRWAGAWSGPVQDSQYVWLPLRFPTATSLAMDWFDSINIDTASGVVEGIT
                     TPIAIDPDAYYQLVNRKSNKPLSIIGNATTDGADLEQRANSGAANQQWQLKDAGSGYYK
                     IVNRNSGKLIGVESGTTTDGTVIEQWSDGGWSSQHWQLVSVTGGYYKLKNRATGKLIDI
                     SEGATADGAKAIQWGDNGGTNQHFRVVKVE"
     gene            25007..25705
                     /locus_tag="PPYC2_RS08390"
                     /old_locus_tag="PPYC2_18405"
     CDS             25007..25705
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-161). E-value: 5.2e-12. Score:
                     37.7. Matches aSDomain:
                     nrpspksdomains_PPYC2_RS08390_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426685.1"
                     /locus_tag="PPYC2_RS08390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC2_18405"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_028542930.1"
                     /transl_table=11
                     /translation="MKIYAIDTSKPEAEEHYELLVNRVSLEKQHKLDRFLHREDALRGL
                     YADVLLRWLVCRQLKVSNASLQFTYNAFGKPSLINAPAFHFNVSHSGKWVVCAIDDHPL
                     GIDIEQLRPIDFEVGRVCFSDKEYDALMRQDADNRLSYFYDLWTLKESFVKAEGQGLTL
                     PLKSFSFELKAQPFIGFTTEGFTTEYCHFKQYELDQDYKMAVCAAHDQFAQQVQQIDIN
                     TLRLEVATQA"
     aSDomain        25316..25489
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PPYC2_RS08390_ACPS.1"
                     /evalue="5.20E-12"
                     /label="PPYC2_RS08390_ACPS.1"
                     /locus_tag="PPYC2_RS08390"
                     /protein_end="161"
                     /protein_start="103"
                     /score="37.7"
                     /tool="antismash"
                     /translation="LGIDIEQLRPIDFEVGRVCFSDKEYDALMRQDADNRLSYFYDLWT
                     LKESFVKAEGQGL"
ORIGIN
        1 taagcatctg atgcatattg tactgaattt gctggataat gcagtgaagt acaatcggga
       61 cggtggatgg attacgttat cgaatcgagt agaacaggac accgtgattg tgtgtatacg
      121 caattccggc ccatggattc ctagggagca atgggacatg atttttgagc cgtttgctac
      181 cttaagccgt gatcgatctc gtcaggacag cggtacggga ctcggtcttc ctctggcgcg
      241 cagactagcg gagcgcatgg ggggagagtt gcagcttaca gcttcagatc atagtgggtt
      301 ggaaaatgac aacgggcata caaatgtaag tgggaatgaa ttttcgctta gactccctct
      361 cttggttcac gatggctccc tgtaaacggc caactgttag cacagggcta aaatggtgtc
      421 ttgtttacaa tttggaaaca atccgatgta ttcatgagat gttcgggcat taaaatgggg
      481 gtatcgttaa caaggaggcc gttgtacatg ataaagaaaa acataggcag ctatgggcaa
      541 aagaacggct cctctcatcg cgaagattcc cgtacaagag ttttcagaca gaaagccacg
      601 ggggtgctca tggccggctt aatcgccggg ggattgttca gcggttgcgg cataaagagc
      661 gcaggagaga caaatccagc atccggtatg aaaccggggc aacagcttac tgtgattgac
      721 acggatgcag cccagcagca agtaacggac gagctggtgg tatcgtctat cgacaggctg
      781 ggggatgtct acgcgaggtc ttggctgagc gacgaagagc tgattgtgga gcgtaaaacc
      841 cagctgtgga ttcataatgt agagacagac aaggagcgga ttttaacacc aggtcgtaag
      901 gctccacagt tacttgctgt ggtatcaccg gatcagcgcc atgtcttttt tactgaaggt
      961 agcaccagca gcaaatatga tattcagggc tacattttgg agctaagcag tggtaaggtt
     1021 acatcgatcg gcaagctgga tatgactaac gaagtgagct ggagcgatga gaatgatctc
     1081 attacaggca caccggatgg taaaatccag ctgattggtc tggacggaaa agctaaagaa
     1141 ttgagttttc aagatccaaa tcgctctgaa ttgatgtctc atgtcgaaaa agtgggtaac
     1201 gccatatttt atacaggcag tgataaacaa gggtatccgg tgctgaatcg gttcaccctc
     1261 aatcatcctc aggctgtgac cattgcagag ggggccatgt cctttgccgt gtcgcctgat
     1321 ggtaagtcaa ttgccattga aaaacggaaa tggaatacat acgaaccagc ccgtatgatc
     1381 attttggatg aacagggcaa agagaaagga atcgtcggtc aaggcacttt aatgagtcgt
     1441 ggaagctggt ccagcgacgg gtccaagctt gcttattcca tttatgatga ggatcagcaa
     1501 ggcatgagag ggctgtatgt gtttgaccag tccactggta aaaccactcc ggttacgacc
     1561 gatatccaat cctatgacag cccaacggta tggagcccat ccgcccggtt tttatccatg
     1621 taccagaaca tctcggaagg tggaaaacag ctcaatcaaa gctacatcgt cgaatttaag
     1681 aggaagtagt ttctggaccc agtcgtacac gaggctcatc gttgacaagg aaatcatacc
     1741 agcggttgcg aaaccgaacc tgaggtccat cagcggggac gtgtgcctcc attcgcagcg
     1801 cttctgggat tggacgcgga tgctggcttt ccaccacggc ccgatcctct tccagcacct
     1861 tgccactgta tctggaaaaa atgtggctca tacccggtac aaatctggca aaattacgtc
     1921 cagccagtcc gtagatggca gttaactctt gctcaatcgg agtgaaggtg acgaaattaa
     1981 taaacttgct gcgtccttcc ttggcgggag tcaaaatcca ttgctgtgga aaggtatatt
     2041 gtaataaacc tttcccgttt tttactcgaa tatgattgtc atccgcttca aactcgatat
     2101 gaatgtcggt ggaggatttt ttaccgatcg ttttgttatg gacaattggc aaatgagcga
     2161 catccagcac gctctccaca actctcgtca gatgtgcctt ccacacggaa tcgtagggag
     2221 acaaaatgag agaggggtcc tccagctcgg ggaaaatctc cagaggaggg ggggatgtgg
     2281 atgttcccaa ccctgagttt atctcagact ttgagccaac ggcctgagga tatacccaca
     2341 gcaggccggc tttttcaatc acgggatagg cataggtatg agcaaactca ggaatagccc
     2401 gtcccggatg tgccggaata tccacacact gcccactctc atcgaaagac catgcatgat
     2461 atgggcatgt gatgtgcccg ttttgacaat agccgagcga caaatcagct cctcggtgcg
     2521 ggcaataagc atggatggca tgtacctgac gatgatcatc acggtacagg acaaaatctt
     2581 tgccaagcaa tcgcttttta agcggtttat tttttaactc cttggaccag ccaacggcgt
     2641 accaggcaat cgggaatacc tgctggtcac tttcacgaac ttcacgaaag ctgggatggg
     2701 tgttcatcta tatcagcgct cctcgttctg cttctcaatt atgacccgtg ggtcatttat
     2761 catattagta taatacaccc ctgatccaaa acgaaacagg tgtcctgaaa ttggcaagaa
     2821 acgaaggtcg cttaaggttg tatgaaatag taaaaaaaag gcgcatatcc tttttaggaa
     2881 tgcccctttt ttaaattagg ctggctattt gattttgtat gactatacaa acttacgatg
     2941 atgtttctta ccgtcatatg agaataaggc gagcttaccc tcaatcaatg tttccaaatg
     3001 aacggtgcgc ccccacagct gatatacata cggaagtgtg cgctccatat attttaaatc
     3061 cagctcaatg ccttcgtact ggtgcttgag cttcaactcg cccgtatgca ggtaatctcc
     3121 atcctcgacg acgatataag gggagcctcc attcacacgt gaaaacacga gctgatcccg
     3181 tatgttttcc caggatttat cggtgatttt ccaatcgggt ccccgtttct caaacacgta
     3241 cagatccaaa tcctctgtca gtttcttggt catgtaattg cgtataaaag aggtgtctga
     3301 gtcgaactct cgtacctcga acattttagc gcgtccttcg cccggtttgc gtccttgtcg
     3361 ctcttgctcc tcacgggttg ggttatccca tcgtttttca atatcctcaa atattttcag
     3421 tcccaaatag tacgggttca ggctttgctt ggaaggctgt acgacagaag cgttcagcat
     3481 cgcaaattca acggtttcct ccccggttaa atccagttcc cttacaatcc gctggtgcca
     3541 ataggaggcc cagccttcat tcatgatttt ggtctccatt tggggccaga aatacagcat
     3601 ttcgtcccgt agcatcgtca taatatcccg ctgccagtcc tccagtacct ccgagaattc
     3661 ctgaataaac cagacgatat ctttttcagg ttccggtgga aactggcgta tcttgatgcc
     3721 ctcggtctcg gctggattat gctgcttcac tgtgtccagt gaccacagat catcgtaagg
     3781 tccaggggga cgctggcgtt ttccgggttc tttctgctcc cgaattttga gctccatgta
     3841 acgctgttta tccagatgcc ttggtttgat aatctgtggg tctacatgct cttgtatcgc
     3901 cagtacagag tcaatgaagg attccacagc ctctgacccg tattccactt catagctgtt
     3961 gattcgatct gctgtggccg acatactctc taccatattg cgattagaag ctgagaagcg
     4021 agcgttgtgt ttgaaaaaat cacagtgtgc cagtacatgg gcgacaatca gtttattttg
     4081 caccaaagaa tttccttcca gcaggaaggc atagcaggga ttggagttaa tgaccagctc
     4141 atagattttg ctcaatccaa aatcgtactg cattttcatc ttgtgaaatg tttttccaaa
     4201 actccagtgg ctgaagcgcg tgggcatacc ataggctccg aacgtgtata caatatccgc
     4261 cggacaaatc tcataccgca tcgggtagta atcgagcccg aatccatcgg caatctccat
     4321 aatttctgat atcgcatatt ctagctcctt ctggtcggta ctcatcccac cgatccccct
     4381 tcccgtttgc gaaaaaaggt acgtaaggct tggtatacct cacctttttc cttgatgaca
     4441 tagtacataa actgatcctt tttaatattc ttgtaggctg acatcagcgt gctgctgcga
     4501 ttatattgat tcacttctcc atagccgaac atattgctcc gctttataag ttcctcgatt
     4561 agcttcacac accgctcatt gtccgaggtc aggttatcgc catccgagaa atggaaggga
     4621 taaatattgt agctggaagg aggatatcgt ttgtcgataa tctccagtgc tttcaaataa
     4681 gcggaagagc agatcgtgcc gccactttct ccgcgggtaa aaaattcttc ttccgtaacc
     4741 tctttagcct cggtatgatg cgcgagaaag acaatttcca ccttttcata ctgacggcgc
     4801 aaaaagcggg tcatccagaa aaagaagctg cgagcgcaat atttttcaaa agagcccatc
     4861 gaacctgagg tgtccatcat agctataatc accgcgttgg attggggaat ggtcttctct
     4921 tcccatgttt tgtagcgaag atcgtccgga ctaatatgat gaatgcccgg tttcccctca
     4981 cgggcgttgc ggcgcagatt ttcgagaatg gttcgtttct tgtcaatgtt cgcttgcatg
     5041 ccttttttac gtatatcatt aaatacgata gattcaacct caatttgatc cttatctttt
     5101 tgctgtaaat tcggcaattc catttcctcg aacagcatat cttccagttc ttctatgctg
     5161 acttccgttt ccataatatc gtgtcccggc tggtcgccgg ctttctcacc tttacctggc
     5221 ttctgggaag caggatcacg tccaatgaca tcccccacct gactgtcgcc atctccttgg
     5281 cctacatgct tttgcttttg atagttataa atgaagcgat attcatccag actgcgaatc
     5341 ggcactttaa taatctgttg accgtccgac ataataatat tttcttccgt tatcagatcg
     5401 ggtagatttt gcttaatgac atctttgacc ttctgctgat gacgttgctg gtcctggtac
     5461 cctttgcgat gcagcgacca atcttcgcgg gatacgacga atgaatatgg ctggcgtggt
     5521 tccggcatta ttaggcaccc cccaagtgga tacacggcac agtttggcct tgttggttat
     5581 taagtatatt cacggggatg aacgatatgt gatggaactc gatttaaatt ctgcccgttt
     5641 gcttttataa tgaaagtaaa aaatgtaaaa aaagaatgga gaaccttggg ttatggaaga
     5701 aattgcagta cttatagtag acgatgagca ggggttgcgg gatatgctga caacggtgtt
     5761 aaaaaaagaa ggattccttc aagtcaagca tgctgcaacg ggtcgggaag cgctgcaagt
     5821 cgtgatggaa tctcatgtgg atgtgattgt acttgatgtt atgctgcctg ataacgatgg
     5881 gtttgaggtg tgtcgtcaaa tgcgtctata tacggatgcc cctattcttt ttttgacggc
     5941 aagagataca gacctagaca aattaatggg gtttggtatc ggaggggacg attatattac
     6001 caaaccgttt aacccgctgg aagtcgttgc gcgtatgaaa gctcgaatga aatatcggaa
     6061 agtttcgaca gtggccatga aaccgacctt acgcacttta gattttggat attttcgtct
     6121 ggaactggaa tccggtgtat tgtatgtgga ggacaagcag gtcgattgtc cggcacgtga
     6181 atggctactg ctggtatttc tgtgcaagca tcctaaccgt attttcagtg tacggcagct
     6241 ttatgaggcg atatggagcg aggccttctt gggtgatgag aagactgtag tgattcatat
     6301 ctcccgtttg cggaaaaaaa tagaacctga tcccaagcac ccgcaatttt taatcaatgt
     6361 aagaggactt ggttataaaa tgatgtcagt caagatggag gagcaagaat gaactctcta
     6421 gttaagatgt cctttcgttt tatgaaagta acattatgct ttgtactggc ctatgtccta
     6481 tgttttgtta tttgcacgat cttatatatt tttataaaaa gtatatttgg agcatctcaa
     6541 aatataaata ttgatctatt ctggacagga cttggtatcg tgcagagtgt tgtgttcata
     6601 gctgcctacg gatggtatat aggcaaacct ttggtgtatg taattaaatg gattggaaat
     6661 attgcgacag gggaattcca agcgccgcta agtgaactgg aactgccaga gggcaaaaaa
     6721 aatcagaaaa atagttataa acctccgtat caattgtata aagaagtttt tgaacaaatg
     6781 aacatcttat cggctcaatt gcgcagcaat gaggaagaga gagtggaatt agagaaacga
     6841 aaacagcagt gggtagcagg tgtaagccat gatctcaaaa caccattatc ttatattgaa
     6901 ggatatgcgg ctatgctaac tgctcaagag tatgactggt ctgatgaaga aagaagaagc
     6961 tttagtatgg gtatcagtga gaaagtgacg gaaatgaagc agttgattca ggatttgaat
     7021 gcttctatgc agcttaagga aggtccattg ccaatccaat tggagaagga ggacattgtg
     7081 gagtttctac gtagtgcggt catagatatc gctaaccatc cttcagccga gcaatacgaa
     7141 ttttctttta cgtcaatgga cgcggcatgt attatgccct tcgatagtaa attattaggc
     7201 agagcgctcc agaatttttt gattaatgct atcattcata atcctccagg tacacacgtt
     7261 tccatggaag taagcaaagc gaacgataag cttcatattt ctatcgaaga cgacggaata
     7321 ggaatgaatt ccaatgagta catgcaggta tctcattccc aagggcatgg aatacctatt
     7381 gccaaaagct ttattgaggc gcataacgga acgcttcata tcctttcagg cagtaaagcg
     7441 ggtactagga tggagatttc actgccgcta aacatctaac tttttaacat ttgatctcac
     7501 attttgcagt ttgctcggtt tttttgcctg ttgtttaggg actgtttacc tgatgtttac
     7561 tttacttcag taaactgtat gtaacttaag cttcagcatt agaagtcgag aggagatcag
     7621 gaaatgtctg aatatgtaat acatacacag cagctaacta ggcgttttgg aaaacgggaa
     7681 tttgtaaaac gaataaatct ccaggtaccc ggacagcaga tttatggatt tttaggacct
     7741 aatggagcgg gtaaaacaac cacgattcgt atgctacttg ggctgattaa atccacatcc
     7801 ggggaaattg agatttttgg gaaaaagctg aaggatcagc gtatggaaat attgaaggat
     7861 attggttcct tggttgaatc acctgcctat tatgcccatt tatccgcata tcgaaattta
     7921 gaaatcgtta caaccatgcg tggactgccg acccgaagaa ttcatgaagt gctggattta
     7981 gtgagattaa ccaaggatgc gtatcgtccg gtaaagggat attccttggg gatgcgacaa
     8041 agactgggga ttgctatggc gcttattgcc aaccccaaat tattgatact tgatgaaccg
     8101 acgaatggtt tggacccgtc tggtattcag gaaattcggg agttaattat gagcctccct
     8161 ggcgcttacg gaatgacggt actagtttcg agccatttat taagcgaaat tgagcagatt
     8221 gcaacctatg taggaattat taatcagggt gaaatgatct tccagggaac gatgaaggaa
     8281 ctcaccgcca aaagcaagcc tcaattattc attgaaaccc cagatcctgt tctggctgcc
     8341 ggtgcactga ttcagcatgg gtggacggcc ggagctgaat cgattgaaca aaatgaggtc
     8401 gtgactccta ttgtagatcg gcaacaatct tcggagatga tcaaggtgct tgtggaacac
     8461 aatcatccca tttatcgggt cacagagaag aaaaaaacat tggaggagat attcctggaa
     8521 ctgacaggta aggagcgaag cttatgatac tccgggttat aaaggcagag gggcttaagc
     8581 tgaagaaaat atgctggtgg attcctctta tacaggggtg tgtacttaca ggcatgactg
     8641 ctgtggaatg gtatctttac tttcggcaag gaccgggagg tgtctacgct ggttttgccg
     8701 ttatgtttat gttcctttcg tttgtgatgc tgcttggcgg tacacttttg gcgagcatta
     8761 tggccggtac agagcatgat actcaaacat ggaagcagct tatggccatg cctgttccca
     8821 gaagttatat ctatttatcc aaaatcgtat ggattgtgat tctgcagttg ggtaccgcct
     8881 tgatcactgt agcaggtatg agcctcatct gggtgttata tacaaacgaa cccattcctt
     8941 ggcggatcat gctgttacag ccgattaatg caagcttggc taccctacca gtacttgcaa
     9001 ttcaactttg gctgtctacg cttttcacta atcaggcatt cccattagcg tttggtatat
     9061 tcggttcaat tgcaagcttg tttttggcac gcacaagtat tctgtggatt aaaatattgc
     9121 cttggtcgta ccctgcatta tcaagtcctc tgatgaagga acacatgatt tgggtgatcg
     9181 ttgctttaag tgcaggagtc atctttacgg gacttggtac actacagttt accaagcatg
     9241 aattcaaata gagaggaaaa gatacatggg ctctatttta cgcgtggaga caataaagct
     9301 tcaatggatc atggtttgga ttctcattat attggatgcg atcataaatt ctttaatggg
     9361 agtcctggaa ctgaatgatt tgaagcagtt tttttcaccc agttggttaa ctttatatac
     9421 ttattcagcg caatttcact ctatgttttt ttatccgctc tattgtggaa ttattgcttc
     9481 tcttttgtgt gcgtacgagc atcgggatgg gggatggaag attttattaa gcagcccgta
     9541 tcctcgtcag caaatttatt atgcaaaata tatattgctc attctcatac tgggtctgga
     9601 tcagcttata tttatagtag gctattttgt aagtggaaat atagcaggtg ctccaggaga
     9661 aatcccttgg tctgtcgttc tttctaccgg tttgggaggg tggctcggga tttttcccct
     9721 ggcagcacta cagcttatgc tctcgataaa aattcggaat tttggagctt ctctaggaat
     9781 gtccatttgt tgtgtggttc ctaatattgt cataacaggc tttcactctt ccataggtgc
     9841 gtggtttcct tttacgattc cttattatat tatgatgccg caaacagcga cttatgcacc
     9901 cagagttgag ccttacagtc tcggactgat tgtcattttt acgtttttag cctatctgta
     9961 tggtggaaga aagatgtttg tgaataggga ctggttgtag ttaggatagc atgaggatgt
    10021 aatcccaacc gatctctttg ttctcagaaa cacttaataa agcagctgca atcccagcaa
    10081 cgccttcaag catgcccgct tttgtcagcc atactagaga gccatctgcc cttggctcgg
    10141 ggtccagata tcctagtggg ctatccattt gaaagcgatc aagcagacaa ttcgttaact
    10201 gttgaataag cgggagaaaa gcaggctctt tactatgaca ccacattcgc caagagatgg
    10261 taagtaatcc ggcaagaccg tgacaaagtg cagaagagtc catttcccgc ttagctatct
    10321 cataggagat tgcaccgaca caagctttca cagccaattt ttgcagttcc tcattatgga
    10381 gagcccttcc ggcaagaaat agggtacagg caatgccagg ggtaccgtaa caccatgctt
    10441 ctcttgctcg ttccaaatca aaccgtagag agcctgtttc agcttcgaat ggaacaatat
    10501 gaggccagta gctaccatat tcatcttcat atttatactt aagcaaccat tccgcaatgg
    10561 tttcaatcgc ttgatattgg ccttttactt caattccagc actgtaagct acagataata
    10621 aagccaacgg tccaggaata ccgtgtgcca ttccacaatt aaaattgccc agaggatagt
    10681 tacgtttatc ccggtctaaa aattgaaact tttgcgggga gtaccaccct gggacataac
    10741 gattgtgaat atgtatggga tgtgtaagat cggtaagaaa ttgaagaatt ggctcaacaa
    10801 gaggagtaca gataggatcg gttgagttca tcaaaatata tcttccaatc cctgaagctc
    10861 ccgaaatggt gtcaaaggct tgcatgggca taccttcgtg aaggcttaat ttttctgtgt
    10921 tcgactgaag ccattgctct gtaagaggca tcatccattg atgtatttgc tgtaagaaat
    10981 tactgtagta ctttccatga ttagaagcct ctcttacgga cgaagcgatg cctgcccagc
    11041 cactgtaaag agagagatcg tgaagaccat ttttagcaag tgaggattgg atctgagcca
    11101 tgtttgaatg tatggctcta ttccaatcat acgaagggtc tgtagcacgc cattgcgata
    11161 gtaaatgaat gttaccagga taaccatgcg aaagtgaagt ttctccccat gggtggtact
    11221 ttgtttctgg cgaaacattg tgttccgcat ggactgctgc atagacggat tcgggctcgc
    11281 atagacgtaa agcaattttt ttactaatat ctcttgcacg aacttggtcg gattgttgta
    11341 taacaaaact atcaattttc atatgaaagc ctccattatt tttttcttca ttatattgtc
    11401 actaaaatct agtgtgttgt ccttaaaaat actaaaaaat aatgaaggtt tatcttaaat
    11461 gtactcgttg aaattaagac aaatgtaaga attatataaa gtctagttaa gattatataa
    11521 cttataataa aattgtaaaa aataaaaagg aggtaacaag atgaaaaatc aatttgatct
    11581 ggacttgcaa gtagctaaaa atgaggttgc tccaaaagga gttcaaccag ccagtggtat
    11641 tatctgtact ccttcatgtg caacaggtac tttgaattgt caagttagtc ttaccttctg
    11701 caaaacgtgt taataacgaa aatacatgga aaaaaggcac ggtttctata accgtgtctt
    11761 ttccagttac gaaaatgagg gaaggattta tggttgaaga tttgaagggg agatcagttg
    11821 aaatcagtaa gtatatagca caaaagctaa tagacctatc atatacagaa aagatagtta
    11881 atcatacaaa caacctttca ccttcacgtg gaaatccccc ttggaatcct ggctcgcttg
    11941 ccgatggaat tccgggtgtg tttgcgctgt tgtccgaatg gggttacctg gagccagatc
    12001 aaaattgggc agagcatgtg catagtcagt tacgatactt agatactaac tctctattat
    12061 tattgcctcg tatttctctt tattatggaa caacaggagt agcttatggc atattattag
    12121 cttccaataa cagagctaat tataacaaac taatctctca gcttaataag tatattgaag
    12181 taaagtgggg ggatttacct gtaattggca caattacaga gttcagtagg caaatggata
    12241 tcatcaatgg gctgctcgga gtgggcagat acactctgga ggttgctgaa gacaagacga
    12301 tgtgtgatct gtctcgtcaa ttattagaca ccattacgca ctttatacct gaatatatac
    12361 atttgtcgtc aagggaagat tcggcttcaa tccatctagg tttggcgcat ggtatcaccg
    12421 gaatacttgc actgcttgtc actgccctac aaaaaaagat caaagttgaa ggactacatg
    12481 aggctataaa acatatagct gattttttgc ttattcaaat tcaggaggat caatatggct
    12541 ggtattggcc tgtaaactct caagcgtctt caatgaacaa gagagagaaa aaagtaggga
    12601 tgagagaaat tgaaggctgg tgtcatggaa cctttggaat agcttggaca ttattcagag
    12661 caggaattga gtgcagtaat gaagaatgga aaaagatagc ggaaaaagct atgcaatcca
    12721 tattttgctt agatgatgag ctactaaacg cgctatcccc tactttctgt cacgggttgg
    12781 ctggtttgct tcatatggct catagattct atagcttaac cggtaatata gcagccttac
    12841 actttgccga tcagatagct ttaaagttag taaatttata cgatgaagag ctcccatttg
    12901 gataccggga tttggagggg acaactcatg ttcataatgt aggaatactg caaggagcaa
    12961 cagggattgc gttaagtttg ctggactatg gaattgggaa agaacatcct aaatattcag
    13021 ggagatggag tgaattgttt ctaatttctt aagggcgctc taccttattg cttatctgaa
    13081 gcattggttt tggggggatt agatgaaaca aaaatttatg gttatatcat cttttaggaa
    13141 gattaagcat ttttttgaga ctttaagcac tccagaaaac attcgaatca tgttttatga
    13201 ttcgctttac caggctctac cggagattga tgagcagtgt atcggtgtag ctttgaatca
    13261 ggatcatata acgctagagg acttgtctta ctggcacagc attaaagaaa aatttacagt
    13321 tccatttatc tttctttcct atcatagtga tgaccaacgg caattggatc tcctcaaaca
    13381 actgttttca atggcttcat ctgcatatga aatggaaaga gaacagcagg ctattagttt
    13441 atcacctaat gtcatttttg atcctgctgg aaaggttatt tggaagcaag ggcatgagca
    13501 tatgctgact atgatggaat tccgattatt aatgtatctt cttactgcaa aagagtgtgc
    13561 ttctacgatt gatcacatta tagacagagt ctggggagtg gatgctttta ctacgtctaa
    13621 tacggtgtat gtgcacatcc gaaaattgag agagaaaata gaagatgatc caagtcatcc
    13681 aaaaattctg gtaacatgtc atggaatcgg ttacaagttg aatatatttc ctaaaaactt
    13741 ggaggtggtc agttgtgaag agacaactgc attacactga tgcgcataaa ctacataatg
    13801 aagtgagaga tcgggatgaa agatggttta gtgcatgtga tttttttcta atcagagctc
    13861 cattactatc gctagaccga tattttcagg tgttttcgga tcaagatgtg gacagccagc
    13921 ttactttgga ggaaataact cgtcgattaa agttgatatc ccaagaagct gttgttcaag
    13981 aagccatagc attagcctct ccgtccctaa tgcagttttt acattacttg aatgatggtc
    14041 atgctttgga tgataaagga gagctacaga agtatgagaa gacgctgaac agcttttatc
    14101 gttattttat tcggatgact acccgaacga ctccatttgg gttattttca ggagtggggc
    14161 aggggatttg cgggaagacc accgatctgg atattggtag ctatcctaag catctgaaga
    14221 gagccagacc cgacatggaa tggatatata aactgattca aaaaatagaa gctgatccgg
    14281 ccatatttaa tcaactaaag gttttcctaa acaaaacggt tatgatcaaa ggaaatcgag
    14341 ccaaattacc atttcgacct aagcatggag cagcagaagc tgatgattcg gcagaaattt
    14401 ttaattccat tcggcttact gacgttgttc gaatgacgtt tgaagctgcg gaacatccaa
    14461 ttcgggtgat ggaactgaaa gaaatactat taaaggcatt ccctgacgct actttggaaa
    14521 tcatagctga ttatttgcag caactagtag agcaagagtt tattttgagc gagcttagac
    14581 ctccgttaat ggatcattca ccctttcatt acatattcga aaaaattaaa aaactggaca
    14641 tttccgatcc ttggattcac attttacacg aaattgatac tttattactt caatataatc
    14701 aatgcacgat tggagaagga gagaaggtct accggaaatt atgtgacaaa atgctggata
    14761 tcatttctgt aaaaacacct gtacaagttg atgttctttt ggataaagaa gtaacgctgc
    14821 cgaaacatgt gcttgatgag gtttcattag gggctgaagt catgtgcaaa ttgtatgcat
    14881 cccccaaaac ggatgaattg gctgaatatt tgaatcgttt cttggaaaag tacggtgtgt
    14941 atcaggaggt tcctattcat gaactgtttg atgaggattg gggtctgggt ataccggaaa
    15001 tgtatcgttc aaatgaaaaa aaatcaatgg gcatggaggc atttaaacgc aacgctgttc
    15061 tttttcaatg ggtttcgaat gccatttcta atcatgaaat agaactcgcc cttacagatg
    15121 aacagttaga gcaactgatg atttctgata actacgacac ttccccagaa tcaatggaga
    15181 tctattacag tatatttgct gagtctcctg aaaaagttga ttctggagac tattcgcttt
    15241 tacttggagc cagtgctggc tcgaatagag cgggtaaaac ctttggacgt tttctggata
    15301 tgtttagtga ggagtttgta caaaaattct ctgaaatata tgatcatcat cgatgctttc
    15361 atcccgatgc gttattgtca gagatggttt ttatgccgga acaggggaaa atatcaaata
    15421 tctcattaag caaaaattta atggcatatg agattgtgtc gggaaccacc tcttctaaag
    15481 atgaggacca tacgctctgt attgatgatt tagtggtggg tgctactcat gatcgttttt
    15541 atgtcaagtc cagacgtttg ggtaaggaaa taatcccctt gcaaacacac atgctgaatt
    15601 acaagctttc accacatata ttcagatttc taacggatat taccaataaa gagattggta
    15661 cgtggtctta ttttgactgg gggccattag agcaatcccc ttttttgcca agactagtat
    15721 ataaaaagat cattattagt gctgcgcagt ggaaactgag caaagcttca ttgaatattt
    15781 cagaatcatg cgagtccaaa gaaggagaag aacttttcca tgtgtggaga caacaatgga
    15841 atgtaccgcg ctatgtttat ctaacgatgg gggataatcg ccttttatta gacctatgta
    15901 acctcttcca tatcaaagaa ttgctacatg aggtgagcaa gacacgtgaa ggacaggaac
    15961 ttcttcttac cgagtgtttg ggtaatccct tccatacccc agtacagggg acggcaggaa
    16021 gatatatggg agaatttgtg tttccactaa agaagaaaaa aataaaggtg aaaccgagta
    16081 tccctagttc acaaaaccat attgtttctc aaaacttcat tactcatact ccttccagca
    16141 ttcatagagg catatttcca ggaggggagt ggctatacct taaattgtac ggagtcaagg
    16201 aaagagagac tgacctggta ggcttaagcc tagggcatct cttaaaacag ccggggttta
    16261 aggattggag tcgaaaattt tactttttgc gatacgttga tcctgaacat catatccgtt
    16321 tacgttttca gggagagccc gataagctat ggacagctgg tttggcgcaa ttaaatcagt
    16381 gggcagccga gttacgtgaa gaggggctaa taacgaatat ggtcatagat acataccatc
    16441 ctgaattgga gaggtatgga ggacagacac ttatggagct ggcagaacag gtttttgacg
    16501 tggatagtca atgggtcatc gcctatatga agggaattcg ctctaatgct ttcaatctgg
    16561 acatagagat tgcggctgtg attaacatta ttcattatct gagtggtttt ggtttaacga
    16621 ttcaggagca agtgaaatgg ctagaagaga gaattgattg caagcctcat atgaaggcgt
    16681 tcagggatgt caaaaaaaca ttgattaccg ctgtagaatc gaattatgaa tggattggac
    16741 aagcagatac gaacacacag gttgctttct tagcgcttgt agaaaaaaga cagactatga
    16801 ttcagcagta tgctcaagcg ataatcctgg ctaaaaataa tcacgaactt accaatcctt
    16861 ctgatgatat tttaggcagc atcattcata tgcatttgaa tcgtctgctt ggtgtaaata
    16921 gggagcgaga aataaaatgt atggctttag ctaagcatac agtagctaac ctgttgcata
    16981 ggaaaggggt aagctatgtc acagtctaat ggacaaacca atgacctgat ctctttgtcc
    17041 tataaaaata tatttcgtac ctttttattt tggcctcgta tattcaggct gctttgggac
    17101 acacatcctt cctttttgat tgctatactc attacgaatt tattgaaggg tgcaattcct
    17161 gctgtgatcc ttttaaccac gagagaatta atcaacagtg tcgtggccgg agcgtcaggg
    17221 ggcagctttc aacctgtttt tatagctttt ggcgtcttga tcggtgtcaa tttgctgtac
    17281 gatctgatca atattggcga aagctttttt cgtaaaatgt ttcaaagccg gctatcgaac
    17341 caggtaaata tcagaattat tgaaaaagca caaaagatgt ctttgcagtc gtttgaggat
    17401 gcagatgtgc aaaatatgct ccaacgtgct cagggagagg cagattttag gccgtttgaa
    17461 atatttactc aaatccttgc cattattagc agtgttgtaa ccttattttc gacgggtgcg
    17521 attctcatcg catggagatg gtgggcattc ttattcattt ttctcattcc atgcttatca
    17581 ttttattctt ttttacgtat cgggcaaaga gaatttaatg ttcactttca aagagcagga
    17641 agacaacgtg aatcctggta cttgtcgttt ttagtgacaa gagataatag ttttaaagaa
    17701 gtgaaaatat ttcaactggg agactatttg cgaaaaagat ataaaacgat actcgaaggg
    17761 ttttatcgcg aggataaagt gctagcggtt cgtagatcct atacctctct tgtatttcag
    17821 attgtaaatc agggtgcgtg tgcatttatt attttcatgg ccatacaagc cacttatgtt
    17881 ggtcaaattt tagtggggaa cttggtgagc ttaattcagg gtatcacgtt aacccagtca
    17941 acatcgcaga gcattgtaca agggatttta agcttgtgtc aaaataattt gtatatcaag
    18001 cagctatttg actttttgga tatgccggaa gaggcaaaaa tacaaaaaac ggttcagcaa
    18061 ttgcctttgt ccactattca cagtattgaa tttcggaatg tatcgtttag atatccgaac
    18121 acagaggaga atgccatttc taatgttagc ttcaagcttc atcaaggaga gaagctagcc
    18181 attgtaggga gaaatggatc gggtaaatca acgattgtga agttactgac tcatttgtat
    18241 tccgattttg aaggagaaat cttaattaat ggacactcaa tacatgaatt ggataaagac
    18301 agttttagag aaaagatagg cgttgttttt caggattttg tacattatga gatggctgtt
    18361 agagataata ttggctttgg taatgtggct tcgagagaaa atgatgaggc catttggaca
    18421 gctatagata aggcggggat tacagatttg atagtcggcc tgcctgataa aatgaatacc
    18481 ttgcttggaa aatggtttga agatggacag cagctatctg gaggacagtg gcagcgtatt
    18541 gcaatagcca gggcctttat gagaaatgcg gatatatatg tcttggatga accgagctct
    18601 tttttggatc cacacgcgga gaaagaggtt tttcaaaagt ttgatcagct tattcatgag
    18661 aaaattggag tgtttatttc acacagattg tcctccgcac gtatggcgga taccattatt
    18721 ttaatggagg agggcaaaat tgtggaagca ggtagtcatg aacacttaat ggatatagac
    18781 ggagtgtatg cagaaatgtt taggctgcaa gcctcctcgt atctttcaca acgagaacgt
    18841 ggttttgagg aaggagatct gtcgccctcg ttagtaagga cgacaggtgg agcctaagaa
    18901 aggacagatg ccctcctatt gtaggagggt aatttttttc ttcaccacaa aagtcgaatt
    18961 acagccatac tcacaatacc gacaacgacg gtagccagca ggtttttgct ccacaaggcg
    19021 gtcactagcg taggaagaac agccataagc acttgcccat taagagtgac tgaggtttcg
    19081 gttcgaacga gcagattttc catcacgagg gccgtgaata tgcagatggg aatataggaa
    19141 agccattgta gcactggctt gggtagcgcc agcctttgca gcacgacaaa gggaatgatc
    19201 cttggaatcg ccgtgacaat catggcaccg ataatgatat acaggacatt gggattaatg
    19261 ttcatttgtc ggttaacact ccaatcgttg cggtgatcat ggtcgctata atgacggcga
    19321 tatgtgatgg cacccaccag gccaaaaggt acatcagaac agccatacat agcacaagca
    19381 gcagacgatg cttgagtttg gaggtctgga cactttggag ctgggaaatg agcagggcaa
    19441 gaaacatcgc tggcaaggca aagtccagac caaaagcctc cggccgggaa atccagttcc
    19501 cgagaacccc tcccgctaca caggatgcaa tccaggcgag ataagctgta atattaagcc
    19561 cgttcatcca gcggtcactg acctgcccgc ctttagccaa tttatccgac gctactccaa
    19621 aggattcgtc cgtcaaaaga acaccgatgc ctatgttttt ccacaatgaa tatttagaaa
    19681 agtaaggagc cagcgacgca cttaacagca gatgacgagc attcacaatg aaagtcgtta
    19741 aaataatgac ggatggagga ctggctgcag ccagcatcga gcacatgata aactgggagg
    19801 ctcctgcgta tacaagcgcc gacatgaagg caatttccat ggtgctaacc cctgatgaag
    19861 cgcccacaat gcctgccgcg aacccaatac atacataacc gagcaatgta ggaatacaat
    19921 ctttaacccc ttgtaaaaag ctgagtgaat cgtgcttcgt tccgctcaac tccgaagcta
    19981 tggacatttt aaccttaccc ccagtgtata aattttataa tagtatataa cgtaagttgt
    20041 aaagtatcaa tatattatac gtttgtatgt tatgttgaat agttcctaca ggagaattgc
    20101 tcttaaaaag ctgttttact gttgacaacc caatgaaggc tatgtattta ccaaaaaggt
    20161 tcggtcgtgt tccggttcca gacgatttgg cagcagccag tcatccaaaa gcggtgttca
    20221 aatgtactcc cgatgagctc ttcgaaatgg caaacgggca agaactgatg atgaatcaaa
    20281 gcagctcgga tgtgttcata taagggctgt tttgactgaa tggggaactc gtaaaaaaag
    20341 ggcgtcccag tcagttcatg acttatgggg caaccctaag gtggtgattt atataagctc
    20401 ctgccgcttt ttcagatatc cgtagagaat aattcccgag atcgcgcaga tggctgcgca
    20461 tagaccgata actccatatc ccgcctgaag tccgcgcagt atgccaagct cagtggttgc
    20521 gccgtagact atcttgaccc ttcgattacc cagccgatca catagttgcc aatgacacta
    20581 cctatgccca tcagcgtgac gacgaacgta atagctgtat cactgtcctt cggatatctc
    20641 cttgctatga acgccatcac ggtcggatag atcattgcaa tacctgcacc tgatacggca
    20701 aagagaaacg ccagtctctc tccacccgcg attgctgcga acgtacatat cgctgagaag
    20761 gcggagaata gaatcgtcga aagcacgaac cccatccggt ctgtgagtgg accaagcaat
    20821 aggcgcccca acgagaaggt aagaaagaac gctgagagca tgctggacgc ctccaccgtg
    20881 ctccatgaat acgctttctc taaaaagttg accagccagc ccccaactgc gagctcagag
    20941 actactccaa acgacaggat cattaccatc atccagagtg ctggatcgcg ggttagcgtc
    21001 ttgagtgagg ttcgatcctc atgctgcaaa tcgtctcccg ggaaggtgct gagcagtgcg
    21061 gccacaatcg gcagcaagca gagcgacaac atagccagat acatcccccg ccagtccagc
    21121 atatgtccaa ataccgtcag tgacatgact cccgtcgcca gcaaaggggc gactgttgag
    21181 ctgagcccat agaaaaagtg ggacaaattc atcatcgtgc cggtattttt cacaaaaatc
    21241 ctcgccccca aaattgcgag cgcaatctcc agcatgccgt tcccgatata catcaagaag
    21301 taggacgagg cgaagaacgg atacgtgtgc gacagataga tgaacactcc cgagatgatc
    21361 atggaagcaa aggaaatgat gctgaccgcc ttgattcccc acttacggac aaggacagcg
    21421 gtgaacgagc aggcaatcaa ataaccaagt gcgtttagag acaacaatgt tccgagctgc
    21481 tgttcatcca gattgaagtc gaattggatg cgtggaatgg cagggccttt aatattttcc
    21541 gagatgccaa atacaataaa gccaataaaa attgtcgcca gctgcatcgt atacatgtgg
    21601 cgggacttgc gggtttgcag attcaaattt agtccctcct agatagccaa acttgatttt
    21661 ctcacctgtt gggtgttcag ggacggaaaa gtcataggat agcagccctc cttcaggata
    21721 ttacaatagt tttgaaaaaa gttttaataa gtgaaaagtt taaggacatt tatattcaat
    21781 gtcaaatgtt tttattgcat gttgaagtaa gcgaggaacc tgaccatatt acaattacag
    21841 taaattgtag catgtctact tcccgtttaa gctttgtatt accttgatcg gctacactta
    21901 atttactgtg gataataagt catgcatcca aaattgcaaa agataaatga tattttacga
    21961 tacagtctat atatagcgaa cacacagtct tttgtgtatt cttcttatat agacttttgg
    22021 atacaaggag gcatcgtccg tggattcaat gcagcatatt attggctcta atttggctca
    22081 aatcaggaag actagaggat taagtttgga taaggtggct gaactgacag gggtcagcaa
    22141 agggatgctg gctcagattg agaaggggaa atccaatcct acggtaacaa ccctttggaa
    22201 aattgcgaac ggtttgcatg tatccttctc cacctttctc aaagaagatc cgccgcaaat
    22261 cacgaagatt cggagggaag acctgcatcc ggttattgat gaggacggta actattttgt
    22321 ttaccctgta ttcccgtatc acgctgaaaa gaagtttgag gtgttcacgg taagtctgaa
    22381 gccaggtttt acacaccagg cagagaagca tttgggggag gaaacgattc tcatgatccg
    22441 tggggaaatg tactttgaaa tgcaggggca acagctcaag ctgagtgcag gggatgccgt
    22501 gcaatttcaa gtatctgaca tacataccta ccggaatgat tcggatgagg atgccgattt
    22561 ttatgtattg atttattatg cggattagtg ggatgattag catagtctaa aacaggcttc
    22621 cacatcatga ttttgcaaaa tcctgagata taaaaagaga gcaacgagga aaagagagga
    22681 aagaatccat ggaaagcaag tacatccgag aaacctactg cttcaagacg tcccgagtat
    22741 ttcccaacga tatcaacaat cataacacgc tcttcggcgg ccgattaatg tcgtatatcg
    22801 acgatatcgc atctattgca gctgctaagc tgtgtcgtac gaacacagtt acagcctcta
    22861 cggattcggt ggattttttg ctacctatcc atccgagtga ttctgtcact ctagaagcgt
    22921 tcgtaacctg gacaggccgt agctcgatgg aggtgttcgt aaaggtaatt cgtgaaggac
    22981 tgatgacggg tgaccgaaaa atcgcagcca ccgcctttct gacctttgtg gcattggacg
    23041 agaacaaccg taaggtgact gtcccgcagg tgattccaga aacagaagag cagttacaat
    23101 tgcaccagac ggctccatca cgcgcagcca tacggcgtca gcggagggaa gaaagcaaac
    23161 agttggctag ttttttgaca acagattatc cgtgggaatt gtaacgtact agagattatc
    23221 aatttcatcg ttttacgtaa aaaggagccg tcttttccgt tagcagtcac catgtctgct
    23281 cggaatacgg ctccttttga aaataacttg agctattcta ctttaactac acggaaatgc
    23341 tgattcgtcc caccattatc gccccattga atggctttgg ctccatcggc ggtggcgcct
    23401 tcagaaatat cgatcagctt gccggttgcc cgatttttca gcttgtaata accaccggtt
    23461 acggatacta attgccaatg ctgactggac cagcctccgt cactccactg ctcaataact
    23521 gtaccgtctg ttgtggtacc gctttcaaca ccaattagct ttccgctgtt gcggttcaca
    23581 attttataat atccgctgcc tgcatccttg agctgccatt gctggtttgc agctccggaa
    23641 tttgcacgct gctccaggtc tgcgccgtcc gtcgttgcat tgccaataat gcttagtggc
    23701 ttattgctct tgcgattcac tagctgataa taggcatccg gatcaatggc aattggcgtt
    23761 gttatcccct cgaccacacc actggcggtg tcaatattaa tgctgtcgaa ccaatccatg
    23821 gctaatgaag tcgctgttgg aaaacgcagt ggcagccata catattgaga atcctgcaca
    23881 ggaccgctcc acgcacccgc ccaacggtcg cccaaataca ggtatgaagt tgtctgggca
    23941 ccttcaacag gaatcacgta agccgactgt gaaccatatg tcgtaccgtc cccgaagttt
    24001 atcgtattac tccaggttcc ttcaatgctg gatgcggtag catacttggc ttgattggga
    24061 ttccagccgg ttgccccgga tgtaatcagg aagtagacgt ctcctttttt gaacatcgcc
    24121 ggagcttcac gatattgtcc tggccaaagt gtagtcacca gcgattcaac ttgcagaaaa
    24181 tccggtgtca gacgatagat gttcagatcc gcgtttaccc gggtagccga aatgaggtaa
    24241 gctgtaccgt tatcgttgta tacggtcata tcgcgcgaat cgtgatccag aggacggaag
    24301 ctgccctgat acgtgtaatc gccgtccacg gtatcggaag aagcgacagc cactcgggcc
    24361 tcgttgtaat taaccccatt ctccttatgc atccataata cgtatttacg tgttttttca
    24421 ttgtaaatca ctttcggacg ttcaatattc gaaacattca gctctacagc ggagctgctg
    24481 gttagtacgt ttttacgaaa ctcccagttt tttaaatcag aggaacggta ggcggatacc
    24541 gccttgaacg tgccgttggg attacgattt tcaccaaacc aataatagta accgtctact
    24601 ttaatcatac cacccccatg ggcatggacc acgtttccat ctgtatcttt aaactgaatg
    24661 ccattcacaa cattcgctga agcggctgaa gcgatcttag gtgaaaacat ctgaaaaatg
    24721 ctcaacgtca gcaaaataga gagcataata cacagcaagc gggcaaaatc atatttcatt
    24781 gtttcgtcct cctctgtatg cgttatttta aagcgctttc attaataggc tctatgaagt
    24841 agttttaata gagatgctta tcccaattgt atccatattg aattgaaagt gctagagtag
    24901 tatattgacc atgtacacgg cacacgccat ccatatctaa cagacttcaa tcgaacggtg
    24961 agtgttacaa actggctgat attcattaga tatacaggag gcaaccatga aaatatacgc
    25021 gattgatacg agcaagccgg aagctgagga gcattacgaa ttactggtaa atcgggtttc
    25081 gctggaaaag cagcacaagt tagatcgttt tttacatcgg gaagatgctt tgaggggctt
    25141 atatgccgat gtgctgctaa gatggttggt ctgccggcaa ttgaaggtat ctaatgctag
    25201 tcttcaattt acatacaatg cgttcggtaa gccttccttg ataaatgcac ccgcattcca
    25261 ttttaatgtt tctcactcgg gaaaatgggt ggtgtgcgct attgatgatc acccgcttgg
    25321 aatcgacatt gaacagctcc gtcctattga ttttgaggta ggtagagtgt gcttttcgga
    25381 caaagagtat gatgcgttaa tgcgtcagga cgcagacaac cgattgtcct atttttacga
    25441 tctatggacg cttaaagaaa gctttgtgaa ggccgagggg cagggactaa ctctaccgtt
    25501 gaagtctttt tcattcgaac tgaaggcaca accgttcata ggcttcacga cagagggctt
    25561 taccaccgag tattgtcatt ttaagcagta tgagttggat caggattata aaatggctgt
    25621 ctgtgcagct catgaccaat ttgcccagca ggtgcagcag atagatataa atacactacg
    25681 cttggaagtg gcaacacagg cgtaatatga agtggatatg cgtatagttg aaaaaaggag
    25741 atgagtggcg ttgacattcg ttttgttcaa gcacggccgg ttgcatgggg attgggcttc
    25801 caaaggagac tccatcgttg tacagcaggg tcggatacaa gccatcggat atgctcggga
    25861 gcttgaattg cagttgaccg gtaaggaata tgaaactgtg gattgggaag acgcctatgt
    25921 actgccaggc ttaaccgatt cacatatgca tttgtctatg catggtatga agctggctat
    25981 gctggattta acatcagcta cctccaagga agagatgctg gctatgctgc gcaaacgggt
    26041 cgctgtaaca ccgccgggag agtggatttt aggacttaac tggaatgaaa atgcgtttat
    26101 tcctgttgaa attccgggta tagccgagct ggatgccatt acagatcagc atccggtata
    26161 tctcactcgt acgtgctttc atacgttctt ggccaattca gaggcatttc ggcgtgcggg
    26221 tattagcgag gacacccctg acccggcttc gggagcctat ggacgagacg cacatggacg
    26281 gttgaacgga ttgatttatg aggaagcatc ctttgccttt actagcgtgc agccagagcc
    26341 ggattattcg gttaagaagg atacgattcg gcgggcttgc ctggatgcgc tacggcttgg
    26401 tctaactgct gcgcacacgg aagatttacg ttttttgggc agcgtggaga cgatgcagcg
    26461 aatttacagg gagctgaggg aagaaggtct tgcttttcgc acacaccagc tcatctatca
    26521 tccctttatg gaagaagcga aagtgcaagg gctgcgtgca ggtaccggaa atgagtggtt
    26581 taaaatcggt gcgattaaaa tgtttgccga tggcgctatt ggtggaagaa cggcattatt
    26641 gtcagaacct tatagtgatg ctccacatac ccgcggaatg gcgattcaac cgcagccaga
    26701 gctgaatcag atggtggcag ctgccagggc cgcaggcttt ccagtggctg tacatgctat
    26761 aggggatggg gcagcgcaca tgattttgac agcgatggag gcccatgtgc tcacggagga
    26821 aagcggtttg ccagatcgcc tgatccatgg acaggtgctt aggagggatt tggtcaagag
    26881 aatggcgaag ctgccgctga ttgcggacat ccagccccgt tttgtcgcaa gtgacttccc
    26941 ttgggtactg gatcgggtgg ggaaagaacg gactgaatat ttatatgcct ggaaaaagct
    27001 gttggaagc
//
