LOCUS       NZ_CP017967            27007 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Paenibacillus polymyxa strain YC0136 chromosome, complete genome.
ACCESSION   NZ_CP017967
VERSION     NZ_CP017967.2
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5621728)
  AUTHORS   Liu,H., Hou,Q., Liu,K., Wang,C., Ding,Y. and Du,B.
  TITLE     Complete Genome Sequence of Paenibacillus polymyxa YC0136, a Plant
            Growth Promoting Rhizobacterium Isolated from Rhizosphere of Tobacco
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5621728)
  AUTHORS   Liu,H., Hou,Q., Liu,K., Wang,C., Ding,Y. and Du,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Department of Microbiology, Shandong
            Agricultural University, No. 61 Daizong Street, Taian, Shandong
            271018, China
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 5621728)
  AUTHORS   Liu,H., Hou,Q., Liu,K., Wang,C., Ding,Y. and Du,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-NOV-2016) Department of Microbiology, Shandong
            Agricultural University, No. 61 Daizong Street, Taian, Shandong
            271018, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Coverage                   :: 193.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:57:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,961
            CDSs (total)                      :: 4,833
            Genes (coding)                    :: 4,774
            CDSs (with protein)               :: 4,774
            Genes (RNA)                       :: 128
            rRNAs                             :: 11, 11, 11 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 11, 11 (5S, 16S, 23S)
            tRNAs                             :: 91
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 19 of 59
            Pseudo Genes (incomplete)         :: 37 of 59
            Pseudo Genes (internal stop)      :: 15 of 59
            Pseudo Genes (multiple problems)  :: 12 of 59
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:21:05
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1783892
            Orig. end                         :: 1810899
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017967.3.
            On Feb 23, 2018 this sequence version replaced NZ_CP017967.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27007
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="8"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27007
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27007
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17007]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17007
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            485..1666
                     /locus_tag="PPYC1_RS07705"
                     /old_locus_tag="PPYC1_16615"
     CDS             485..1666
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820485.1"
                     /locus_tag="PPYC1_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16615"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_069080726.1"
                     /transl_table=11
                     /translation="MIKKNIDSYGQKNGSPRREDSRTRVFRQKATGVLMAGLIAGGLLS
                     GCGMKSAGETNPASGMKPGQQLTVIDTDAAQQQVTDELVVSSIDRLGDVYARSWLSDEE
                     LIVERKTQLWIHNVETDKERILTPGRKAPQLLAVVSPDQRHVFFTEGSTSSKYDIQGYI
                     LELSSGKVTPIGKLDMTNEVSWSDENDLITGTPDGKIQLIGLDGKAKELSFQDPNRSEL
                     MSHVEKVGNAIFYTGSDKQGYPVLNRFTLNHPQAVTIAEGAMSFAVSPDGKSIAIEKRK
                     WNTSEPARMIILDEQGKEKGIVGQGTLMSRGSWSSDGSKLAYSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSPSARFLSMYQNISEGGKQLNQSYIVEFKRK"
     gene            complement(1653..2684)
                     /locus_tag="PPYC1_RS07710"
                     /old_locus_tag="PPYC1_16610"
     CDS             complement(1653..2684)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014649242.1"
                     /locus_tag="PPYC1_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16610"
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_071640085.1"
                     /transl_table=11
                     /translation="MNTHPSFREVRESDQQVFPIAWYAVGWSKELKNKPLKKRLLGKDI
                     VLYRDDHRQVHAIHAYCPHRGADLSLGYCQNGHITCPYHAWSFDESGQCVDIPAHPGRA
                     IPEFAHTYAYPATEKAGLLWVYPQAVGSNSEINSGLGTSTSPPPLEIFPELEDPSLILS
                     PYDSMWKAHLTRVVESVLDVAHLPIVHNKTIGKKSSTDIHIEFEADDNHIRVKNGKGLL
                     QYTFPQQWILTPAKEGRSKFINFVTFTPIEQELTAIYGLAGRNFARFVPGMSHIFSRYS
                     GKVLEEDRAVVESQHPRPIPEALRMEAHVPADGPQVRFRNRWYDFLVNDEPRVRLGPET
                     TSS"
     gene            complement(2922..4364)
                     /locus_tag="PPYC1_RS07715"
                     /old_locus_tag="PPYC1_16605"
     CDS             complement(2922..4364)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="PPYC1_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16605"
                     /product="SpoVR family protein"
                     /protein_id="WP_071640086.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIADGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLEGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATADRINSYEMEYGSKAVESFIDSVLAIQEHVDP
                     QIIKPRHLDKQRYMELKIREQKEPGKRQRPPGPYDDLWSLDTVKQHDPAETEGIKVRQF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGEETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKMFEVREFDSDTSFIRNYMTKKLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TLIEGKLALFSYDGKKHHRKFV"
     gene            complement(4361..5527)
                     /gene="yhbH"
                     /locus_tag="PPYC1_RS07720"
                     /old_locus_tag="PPYC1_16600"
     CDS             complement(4361..5527)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="PPYC1_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16600"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_025723949.1"
                     /transl_table=11
                     /translation="MPEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPNLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGKPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSSYNIYPFHFSDGDNLTSDNERCVKLIEELIKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKKDQFMYYVIKEKGEVYQALRTFFRKREGGTVG"
     gene            5692..6411
                     /locus_tag="PPYC1_RS07725"
                     /old_locus_tag="PPYC1_16595"
     CDS             5692..6411
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="PPYC1_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16595"
                     /product="response regulator transcription factor"
                     /protein_id="WP_071640087.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTTVLKKEGFLQVKHAATGREALQVVM
                     ESHMDVIVLDVMLPDSDGFEVCRQMRLYTDAPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVVARMKARMKYRKVSTVAMKPTLRTLDFGYFRLELESGVLYVEGKEVDCPARE
                     WLLLVFLCKHPNRIFSVRQLYETIWSEAFLGDEKTVVIHISRLRKKIEPDPKHPQFLIN
                     VRGLGYKMMSVKMGEQE"
     gene            6408..7478
                     /locus_tag="PPYC1_RS07730"
                     /old_locus_tag="PPYC1_16590"
     CDS             6408..7478
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="PPYC1_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16590"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_071640088.1"
                     /transl_table=11
                     /translation="MNSLVKMSFRFMKVTLCFVLAYVLCFVICTILYIFIKSIFGASQN
                     INIDLFWTGLGIVQSVVFIAAYGWYIGKPLVYVIKWIGNIATGEFQAPLSELELPEGKK
                     NQKNSYKPPYQLYKEVFEQMNILSAQLRSNEEERVELEKRKQQWVAGVGHDLKTPLSYI
                     EGYAAMLTAQEYDWSEEERRSFSMSISEKVTEMKQLIQDLNASMQLKESPLPIQLEKED
                     IVEFLRSTVIDIANHPSAEQYEFSFTSMEAACIMPFDSKLLGRALQNFLINAIIHNPPG
                     THVSMEVSKANDKLHISIEDDGIGMNPNEYMQISHSQGHGIPIAKSFIEAHNGTLHILS
                     GSKAGTRMEISLPLNI"
     gene            7624..8547
                     /locus_tag="PPYC1_RS07735"
                     /old_locus_tag="PPYC1_16585"
     CDS             7624..8547
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="PPYC1_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16585"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_029516536.1"
                     /transl_table=11
                     /translation="MSEYVIHTQQLTRRFGKREFVKRINLQVPGQQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGEIEIFGKKLKDQRMEILKDVGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRRIHEVLDLVRLAKDAYRPVKGYSLGMRQRLGIAMALIANPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPGAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTA
                     KSKPQLFIETPDPVLAAGALIQHGWTAGAESIEQNEVVTPIVDRQQSSEMIKVLVEHNH
                     PIYRVTEKKKTLEEIFLELTGKERSL"
     gene            8544..9251
                     /locus_tag="PPYC1_RS07740"
                     /old_locus_tag="PPYC1_16580"
     CDS             8544..9251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="PPYC1_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16580"
                     /product="ABC transporter permease"
                     /protein_id="WP_025723953.1"
                     /transl_table=11
                     /translation="MILRVIKSEGLKLKKICWWIPLIQGCVLTGMTAVEWYLYFRQGPG
                     GVYAGFAVMFMFLSFVMLLGGTLLASIMAGTEHDTQTWKQLMVMPVPRSYIYLSKIVWI
                     VILQLGTALITVAGMSLIWVLYTNEPIPWRIMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKILPWSYPALSSPLMKEHMIWVIVALSAGVIFT
                     GLGTLQFTKHEFK"
     gene            9266..10000
                     /locus_tag="PPYC1_RS07745"
                     /old_locus_tag="PPYC1_16575"
     CDS             9266..10000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="PPYC1_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16575"
                     /product="ABC transporter permease"
                     /protein_id="WP_025723954.1"
                     /transl_table=11
                     /translation="MGSILRVETIKLQWIMVWILIILDAVINSLMGVLELNDLKQFFSP
                     SWLTLYTYSAQFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQQIYYAKYIL
                     LILILGLDQLIFIAGYFVSGNIAGAPGEIPWSVVLSTGLGGWLGIFPLAALQLMLSIKI
                     RNFGASLGMSICCVVPNIVITGFHSSIGAWFPFTIPYYIMMPQTATYAPRVEPYSLGLI
                     VIFTFLAYLYGGRKMFVNRDWL"
     gene            complement(10001..11362)
                     /locus_tag="PPYC1_RS07750"
                     /old_locus_tag="PPYC1_16570"
     CDS             complement(10001..11362)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="PPYC1_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16570"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_071640089.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-56, bitscore:
                     189.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDSFVIQQSDQVRARDISKKIALRLCEPESVYAAVRSEHNVSP
                     ETKYHPWGETSLSHGYPGNIHLLSQWRATDPSYDWNTAIHSNMAQIQSSLSKNGLHDLS
                     LYSGWAGIASSVREASNHGKYYSNFLQQIHQWMMPLTEQWLQSNTEQLSLHEGMPMQAF
                     DTISGASGIGRYILMNSTDPICTPLVEPILQFLTDLTHPIHIHNRYVPGWYSPQKFQFL
                     DRDKRNYPLGNFNCGMAHGIPGPLALLSVAYSAGIEVKGQYQAIETIAEWLLKYKYEDE
                     YGSYWPHIVPFEAETGSLQFDLERAREAWCYGTPGIACTLFLAGKALHNEELQKLAVKA
                     CVGAISHEIAKREMDSSALCHGLAGLLTISWRMWCHSKEPAFFPLIQQLTNCLLDRFQM
                     DSPLGYLDPEPRSDGSLTWLTKAGMLEGVAGIAAALLSVSENKEIGWDYILMLS"
     gene            11560..11712
                     /locus_tag="PPYC1_RS07755"
                     /old_locus_tag="PPYC1_16565"
     CDS             11560..11712
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="PPYC1_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16565"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_071640090.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.1e-05, bitscore:
                     22.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKDEVASKGVQPASGIICTPSCATGTLNCQVSLT
                     FCKTC"
     CDS_motif       11560..11631
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKDEVASKGVQPA"
                     /locus_tag="PPYC1_RS07755_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11632..11712
                     /prepeptide="core"
                     /locus_tag="PPYC1_RS07755_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="6.40"
                     /molecular_weight="2508.0"
                     /monoisotopic_mass="2506.2"
                     /core_sequence="SGIICTPSCATGTLNCQVSLTFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKDEVASKGVQPA"
                     /leader_location="[11559:11631](+)"
                     /alternative_weights="2526.0"
                     /alternative_weights="2544.0"
                     /alternative_weights="2562.0"
     gene            11768..13051
                     /locus_tag="PPYC1_RS07760"
                     /old_locus_tag="PPYC1_16560"
     CDS             11768..13051
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="PPYC1_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16560"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_233901843.1"
                     /sec_met_domain="LANC_like (E-value: 6.1e-58, bitscore:
                     194.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMREGFMVEDLKGRSVEISKYIAQKLIDLSYTEKIVNHTNNLSP
                     SRGNPPWNPGSLADGIPGVFALLSEWGYLEPDQNWAEHVHSQLRYLDANSLLLLPRISL
                     YYGTTGVAYGILLASNNRANYNKLISQLNKYIEVKWGDLPVIGTITEFSRQMDIINGLL
                     GVGRYTLEVAEDKTMCDLSRQLLDTITHFIPEYIHLSSREDSASIDLGLAHGITGILAL
                     LVTALQKKIKVEGLHEAIKHIADFLLIQIQEDQYGWYWPVNSQASSMNKREKKVGMREI
                     EGWCHGTFGIAWTLLRAGIECSNEEWKKIAEKAMESIFCLDDELLNALSPTFCHGLAGL
                     LHMAHRFSSLTDNIAALRFADQIALRLVNLYDEELPFGYQDLEGTTHVHNVGILQGATG
                     IALSLLDYGIGKEHPKYSGRWSELFLIS"
     gene            13101..13778
                     /locus_tag="PPYC1_RS07765"
                     /old_locus_tag="PPYC1_16555"
     CDS             13101..13778
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="PPYC1_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16555"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_071640092.1"
                     /transl_table=11
                     /translation="MKQKFMVISSFRKIKHFFETLSTPENIQIMFYDSLYQAITEIDEQ
                     CIGVALNQDHITLEDLSYWHSIKEKFKVPFIFLSYHSDDQQQLDLLKQLFSMASSKYGM
                     EREQQAISLSPNVIFDPAGKVIWKQGHEHMLTMMEFRLLMYLLTAKECASTIDHIIDRV
                     WGVDAFTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYKLNIFPKNLEVVSCEETT
                     ALH"
     gene            13906..17007
                     /locus_tag="PPYC1_RS07770"
                     /old_locus_tag="PPYC1_16550"
     CDS             13906..17007
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370171.1"
                     /locus_tag="PPYC1_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16550"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_233901877.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.9e-191,
                     bitscore: 635.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3e-15,
                     bitscore: 54.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.4e-52, bitscore:
                     175.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSQLTLEEITRRLKLISQEAVVQEAISLASPSLMQFLHYLNDGH
                     ALDDKGELQKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICGKTTDLDIGSYPKHLK
                     RARPDMEWIYKLIQKIEADPAIFNQLKVFLNKTVMIKGNRAKLPFRPKHGAAEADDSAE
                     IFNSIRLTDVVRMTFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSE
                     LRPPLMDHSPFHYIFEKIKKLDISDPWIHILHEIDALLLQYNQCTIGEGEKVYRKLCDK
                     MLDIISVKTPVQVDVKLDKEVTLPKHVLDEVSLGAEVMCKLYASPKTDELDEYLNRFLE
                     KYGVYQEVPIHELFDEDWGLGIPEMYRSNEKKSMGMEAFKRNAVLFQWVSDAISNHEIE
                     LALTDEQLEQLMISDNYDTSPESMEIYYSIFADSPEKVDSGDYSLLLGASAGSNRAGKT
                     FGRFLDMLSEEFVQKFSEIYDHHRCFHPDALLSEMVFMPEQGKISNISLSKNLMAYEIV
                     SGTTSSKDEDHTLCIDDLVVGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPHIFRFLT
                     DITNKEIGTWSYFDWGPLEQSPFLPRLVYKKIIISAAQWKLSKASLNISESCESKEGEE
                     LFHVWRQQWNVPRYVYLTMGDNRLLLDLCNLFHIKELLHEVSKTREGQELLLTECLGNP
                     FHTPVQGTAGRYMGEFVFPLKKKKIKVKPSIPSSQNHIVSQNFITHTPSSIHRGIFPGG
                     EWLYLKLYGVKERETDLVGLSLGHLLKQPGFKDWSQKFYFLRYVDPEHHIRLRFRGEPD
                     KLWTAGLAQLNQWAAELREEGLITNMVIDTYHPELERYGGQTLMELAEQVFDVDSQWVI
                     TYMKGIRSNAFNLDIEIVAVMNIIHYLSGFGLTIQEQVKWLEERIDCKPHMKAFRDVKK
                     TLITAVESNYEWIGQADTNTQVAFLALVEKRQTMIQKYAQAIILAKNNHELTNHPDDIL
                     GSIIHMHLNRLLGVNREREIKCMALAKHTVANLLHRKGVSYVTV"
     aSDomain        14299..14583
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PPYC1_RS07770_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-17"
                     /identifier="RREFam001.1"
                     /label="PPYC1_RS07770"
                     /locus_tag="PPYC1_RS07770"
                     /protein_end="226"
                     /protein_start="131"
                     /score="54.8"
                     /tool="antismash"
                     /translation="VFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRLTDVVRM
                     TFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSELRPP"
     gene            17033..18895
                     /locus_tag="PPYC1_RS07775"
                     /old_locus_tag="PPYC1_16545"
     CDS             17033..18895
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="PPYC1_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16545"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_230486418.1"
                     /transl_table=11
                     /translation="MSYKNIFRTFLFWPRIFRLLWDTHPSFLIAILITNLLKGAIPAVI
                     LLTTRELINSVVAGASGGSFQPVFIAFGVLIGVNLLYDLINIGESFFRKMFQSRLSNQV
                     NIRIIEKAQKMSLQSFEDADVQNMLQRAQGEADFRPFEIFTQILAIISSVVTLFSTGAI
                     LIAWRWWAFLFIFLIPCLSFYSFLRIGQREFNVHFQRAGRQRESWYLSFLVTRDNSFKE
                     VKIFQLGDYLRKRYKTILEGFYREDKVLAVRRSYTSLVFQIVNQGACAFIIFMAIQATY
                     VGQILVGNLVSLIQGITLTQSTSQSIVQGILSLCQNNLYIKQLFDFLDMPEEAKIQKSV
                     QQLPLSAIHSIEFRNVSFRYPNTEENAISNVSFKLHQGEKLAIVGKNGSGKSTIVKLMT
                     HLYSDFEGEILINGHSIHELDKDSFREKIGVVFQDFVHYEMAVRDNIGFGNVASRENDE
                     AIWTAIDKAGITDLIVGLPDKINSLLGKWFEDGQQLSGGQWQRIAIARAFMRNADIYVL
                     DEPSSFLDPHAEKEVFQKFDQLIHEKIGVFISHRLSSARMADIIILMEEGRIVEAGSHE
                     RLMDIDGVYAEMFRLQASSYLSQRERGFEEENLSPSLVRTTGGS"
     gene            complement(18940..19263)
                     /locus_tag="PPYC1_RS07780"
                     /old_locus_tag="PPYC1_16540"
     CDS             complement(18940..19263)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003331885.1"
                     /locus_tag="PPYC1_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16540"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_025723962.1"
                     /transl_table=11
                     /translation="MNINPNVLYIIISAMIVTAIPRIIPFVVLQRLALPKPVLQWLSYI
                     PICIFTALVMENLLVRTETSVTLNGQVLMAVLPTLVTALWSKNLLATVVVGIVSMAVVR
                     LLW"
     gene            complement(19260..19985)
                     /locus_tag="PPYC1_RS07785"
                     /old_locus_tag="PPYC1_16535"
     CDS             complement(19260..19985)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="PPYC1_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16535"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_071640094.1"
                     /transl_table=11
                     /translation="MSIASELSGTKHDSLSFLQGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIAFMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLWKNIGIGVLLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIASCVAGGVLG
                     NWISRPEAFGLDFALPAMFLALLISQLQSIQTSKLKHRLLLVLCMAVLMYLLAWWVPSH
                     IAVIIATMITATIGVLTDK"
     misc_feature    20005..20018
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     gene            20140..20313
                     /locus_tag="PPYC1_RS07790"
                     /old_locus_tag="PPYC1_16530"
     CDS             20140..20313
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PPYC1_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PPYC1_16530"
                     /product="hypothetical protein"
                     /protein_id="WP_158659098.1"
                     /transl_table=11
                     /translation="MYLPIRFGRVPVPDDLAAASHPKAVFKCTPDKLFEMANGQEMMMN
                     QSSSDVFIQGLF"
     gene            complement(20387..21625)
                     /locus_tag="PPYC1_RS07795"
                     /old_locus_tag="PPYC1_16525"
     CDS             complement(20387..21625)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426681.1"
                     /locus_tag="PPYC1_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16525"
                     /product="MFS transporter"
                     /protein_id="WP_071640096.1"
                     /transl_table=11
                     /translation="MNLQTRKSHHMYTMQLATIFIGFIVFGISENIKGPAIPRIQFDFN
                     LDEQQLGTLLSLNALGYLIACSFTAVLVRKWGIKAVSIISFASMIISGVFIYLSHTYPF
                     FASSYFLMYIGNGMLEIALAILGARIFVKNTGTMMNLSHFFYGLSSTVAPLLATGVMSL
                     TVFGHMLDWRGMYLAMLSLCLLPIVAALLSTFPGDDLQHEDRTSLKTLTRDPALWMMVM
                     ILSFGVVSELAVGGWLVNFLEKAYSWSTVKASSMLSAFFLTFSLGRLLLGPLTDRMGFV
                     LSTILFSAFSAICTFAAIAGGERLAFLFAVSGAGIAMIYPTVMAFIARRYPKDSDTAIT
                     FVVTLMGIGSVIGNYVIGWVIEGVKIVYGATTELGILRGLQAGYGVIGLCAAICAISGI
                     ILYGYLKKRQELI"
     gene            22032..22580
                     /locus_tag="PPYC1_RS07800"
                     /old_locus_tag="PPYC1_16520"
     CDS             22032..22580
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429618.1"
                     /locus_tag="PPYC1_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16520"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_023987843.1"
                     /transl_table=11
                     /translation="MDSMQHIIGSNLAQIRKTRGLSLDKVAELTGVSKGMLAQIEKGKS
                     NPTVTTLWKIANGLHVSFSTFLKEDPPQITKIRREDLHPVIDEDGNYFVYPVFPYHAEK
                     KFEVFTVSLKPGFTHQAEKHLGEETILMIRGEMYFEMQGQQLKLSAGDAVQFQVSDIHT
                     YRNDSDEDADFYVLIYYAD"
     misc_feature    complement(22624..22638)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.31"
                     /tool="antismash"
     gene            22681..23196
                     /locus_tag="PPYC1_RS07805"
                     /old_locus_tag="PPYC1_16515"
     CDS             22681..23196
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280639.1"
                     /locus_tag="PPYC1_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16515"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_013309488.1"
                     /transl_table=11
                     /translation="MESKYIRETYCFKTSRVFPNDINNHNTLFGGRLMSYIDDIASIAA
                     AKLCRTNTVTASTDSVDFLLPIHPSDSVTLEAFVTWTGRSSMEVFVKVIREGLMTGDRK
                     IAATAFLTFVALDENNRKVTVPQVIPETEEQLQLHQTAPSRAAIRRQRREESKQLASFL
                     TTDYPWEL"
     gene            complement(23306..24772)
                     /locus_tag="PPYC1_RS07810"
                     /old_locus_tag="PPYC1_16510"
     CDS             complement(23306..24772)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686791.1"
                     /locus_tag="PPYC1_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16510"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_071640097.1"
                     /transl_table=11
                     /translation="MKYDFARLLCIMLSILLTLSIFQMFSPKVASAASANVVNGIQFKD
                     TDGNVVHAHGGGMIKVDGYYYWFGENRNPNGTFKAVSAYRSSDLKNWEFRKNVLTSSSA
                     VELNVSNIERPKVIYNEKTRKYVLWMHKENGVNYNEARVAVASSDTVDGDYTYQGSFRP
                     LDYDSRDMTVYNDNGTAYLISATRVNADLNIYRLTPDFLQVESLVTTLWPGQYREAPAM
                     FKKGDVYFLITSGATGWNPNQAKYATASSIEGTWSNTINFGDSTTYGSQSAYVIPVEGA
                     QTTSYLYLGDRWAGAWSGPVQDSQYVWLPLRFPTATSLAMDWFDSINIDTASGVVEGIT
                     TPIAIDPNAYYQLVNRKSNKPLSIIGNATTDGADLEQRVNSGAANQQWQLKDADSGYYK
                     IVNRNSGKLIGVESGTTTDGTVIEQWSDGGWSSQHWQLVSVTGGYYKLKNRATGKLIDI
                     SEGATADGAKAIQWGDNGGTNQHFRVVKVE"
     gene            24999..25697
                     /locus_tag="PPYC1_RS07815"
                     /old_locus_tag="PPYC1_16505"
     CDS             24999..25697
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-161). E-value: 6.4e-12. Score:
                     37.4. Matches aSDomain:
                     nrpspksdomains_PPYC1_RS07815_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426685.1"
                     /locus_tag="PPYC1_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PPYC1_16505"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_071640098.1"
                     /transl_table=11
                     /translation="MKIYAIDTSKPEAEEHYELLVNRVSLEKQHKLDRFLHREDALRGL
                     YADVLLRWLACRQLKVSNASLQFTYNAFGKPSLINAPAFHFNVSHSGKWVVCAIDDHPL
                     GIDIEQLRPIDFEVGRVCFSDTEYDALMRQDADSRLSYFYDLWTLKESFVKAEGQGLTL
                     PLKSFSFELKAQPFIGFTTEGFTTEYCHFKQYELDQDYKMAVCAAHDQFAQQVQQLDIN
                     TLRLEVATQA"
     aSDomain        25308..25481
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PPYC1_RS07815_ACPS.1"
                     /evalue="6.40E-12"
                     /label="PPYC1_RS07815_ACPS.1"
                     /locus_tag="PPYC1_RS07815"
                     /protein_end="161"
                     /protein_start="103"
                     /score="37.4"
                     /tool="antismash"
                     /translation="LGIDIEQLRPIDFEVGRVCFSDTEYDALMRQDADSRLSYFYDLWT
                     LKESFVKAEGQGL"
ORIGIN
        1 tgaatttgct ggataatgca gtgaagtaca atcgggacgg tggatggatt acgttatcga
       61 atcgagtaga acaggacacc gtgattgtgt gtatacgcaa ttccggccca tggattccta
      121 gggagcaatg ggacatgatt tttgagccgt ttgctacctt aagtcgtgat cgatctcgtc
      181 aggacagcgg tacgggactt ggtcttcctc tggcgcgcag actggcggag cgcatggggg
      241 gagagttgca gcttacagct tcagatcata gtgggttgga aaatgacaac gggcatacaa
      301 atgtaagtgg gaatgaattt tcgcttagac tccctctctt ggttcacgat ggctccctgt
      361 aaacggccga ttgttagcac agggctaaaa tggtgtcttg tttacaactt ggaaacaatc
      421 cgatgtattc atgagatgtt cgggcattaa actgggggta tcgttaacaa ggaggccgtt
      481 gtacatgata aagaaaaaca tagacagcta tgggcaaaag aacggctccc ctcgtcgcga
      541 agattcccgc acaagagttt tcagacagaa agctacgggg gtgctcatgg ccggcttaat
      601 cgccggggga ttgctcagcg gttgcggcat gaaaagcgca ggagagacaa atccagcatc
      661 cggtatgaaa ccgggccaac agcttactgt gattgacacg gatgcagccc agcagcaagt
      721 aacggacgag ctggtggtat cgtctatcga caggctgggg gatgtctacg cgaggtcttg
      781 gctgagcgac gaagagctga ttgtggagcg taaaacccag ctgtggattc ataatgtaga
      841 gacagacaag gagcggattt taacaccagg tcgtaaggct ccgcagttac ttgctgtggt
      901 atcaccggat cagcgccatg tcttttttac tgaaggtagc actagcagca aatatgatat
      961 ccagggctac attttggagc taagcagtgg taaggttaca ccgatcggca agctggatat
     1021 gactaacgaa gtgagctgga gcgatgagaa tgatctcatt acaggcacac cggatggtaa
     1081 aatccagctg attggtctgg acggcaaagc taaagaattg agttttcaag atccgaatcg
     1141 ctctgaattg atgtctcatg tcgaaaaagt gggtaacgcc atattttata caggcagtga
     1201 taaacaaggg tatccggtgc tgaatcggtt cacccttaat catcctcagg ctgtgactat
     1261 tgcagagggg gccatgtcct ttgccgtgtc gcctgatggt aagtctattg ccattgaaaa
     1321 gcggaaatgg aatacatccg aaccagcccg tatgatcatt ttggatgaac agggcaaaga
     1381 gaaaggaatc gtcggtcaag gcactttaat gagtcgtgga agctggtcca gcgacgggtc
     1441 caagcttgct tattccattt atgatgagga tcagcaaggc atgagagggc tgtatgtgtt
     1501 tgaccagtcc acgggtaaaa ccactccggt tacgaccgat atccaatcct atgacagccc
     1561 aacggtatgg agcccatccg cccggtttct atccatgtac cagaacatct cggaaggtgg
     1621 aaaacagctc aatcaaagct acatcgtcga atttaagagg aagtagtttc tggacccagt
     1681 cgtacacgag gctcatcgtt gacaaggaaa tcataccagc ggttgcgaaa ccgaacctga
     1741 ggtccatcag cggggacgtg tgcctccatt cgcagcgctt ctgggattgg acgcggatgc
     1801 tggctttcca ccacggcccg atcctcttcc agcaccttac cactgtatct cgaaaaaatg
     1861 tggctcatgc ccggtacaaa tctggcaaaa ttacgtccag ccagtccgta gatggcagtt
     1921 aactcttgct caatcggagt gaaggtgacg aaattaataa acttgctgcg tccttccttg
     1981 gcgggagtca aaatccattg ctgtggaaag gtatattgta atagaccttt cccgtttttc
     2041 actcgaatat gattgtcatc cgcttcaaac tcgatatgaa tgtcggtgga ggatttttta
     2101 ccgattgttt tgttatggac aattggcaaa tgagcgacat ccagcacgct ttccacaact
     2161 ctcgtcagat gtgccttcca catggaatcg tagggagaca aaatgagaga ggggtcctcc
     2221 agctcgggaa aaatctccag aggaggtggg gatgtggatg tccccaaccc tgagtttatt
     2281 tcagaatttg agccaacggc ctgaggatat acccacagca ggccggcttt ttcagtcgcg
     2341 ggataggcat aggtatgagc aaactcagga atagcccgtc ccggatgtgc cggaatatcg
     2401 acacactgcc cactctcatc gaaagaccat gcatgatatg ggcatgtgat gtgcccgttt
     2461 tgacaatagc ctagcgacaa atcagctcct cggtgcgggc aataagcatg gatggcatgt
     2521 acctgacgat gatcatcacg gtacaggaca atatctttgc caagcagtcg ctttttaagc
     2581 ggtttattct ttagttcctt ggaccagcca acggcatacc aggcgatcgg gaatacctgc
     2641 tgatcacttt cacgaacttc acgaaagctg ggatgggtgt tcatctatat caacgctcct
     2701 cgttctgctt ctcaactatg acccgtgggt catttatcat attagtataa tacacccctg
     2761 aaccaaaacg aaacaggtgt cctgaaattg gcaagaaacg aaggtcgctt aaggttgtat
     2821 gaaaaggtcg cttaaggttg tatgaaatag taagaaaagg cgcatatcct ttttaggaat
     2881 gcaccttttt taaattaggc tggctatttg atttggtatg actatacaaa cttacgatga
     2941 tgtttcttac cgtcatatga gaatagggcg agcttaccct caatcaatgt ttccaaatga
     3001 acggtgcgtc cccacagctg atatacatat ggaagcgtgc gctccatata ttttaaatcc
     3061 agctcaatgc cttcgtactg gtgcttgagc ttcaactcgc ccgtatgcag gtaatctcca
     3121 tcctcgacga cgatataagg ggagcctcca ttcacacgtg aaaacacaag ctgatctcgt
     3181 atgttttccc aggatttatc ggtaattttc caatcgggtc cccgtttctc aaacacgtat
     3241 agatccaaat cctctgtcag tttcttggtc atgtaattac gtataaaaga agtgtctgag
     3301 tcgaactctc gtacctcgaa catcttagcg cgtccttcgc ccggtttgcg tccttgtcgc
     3361 tcttgttcct cacgggttgg gttatcccat cgtttttcaa tatcctcaaa tattttcagt
     3421 cccaaatagt acgggttcag gctttgcttg gaaggctgta cgacagaggc gttcagcatc
     3481 gcaaattcaa cggtttcctc cccggtcaaa tccagttccc ttacaatccg ctggtgccaa
     3541 taggaggccc agccttcatt cattattttg gtctccattt ggggccagaa atacagcatt
     3601 tcgtcccgca gcatcgtcat aatgtcccgc tgccagtcct ccagcacctc tgagaattcc
     3661 tgaataaacc agacgatatc tttttcaggt tccggtggaa actggcgtac tttgatgccc
     3721 tcggtctcgg ccggatcatg ctgcttcact gtgtccagtg accacagatc atcgtaaggc
     3781 ccagggggac gttggcgttt tccaggttct ttctgctccc gaattttgag ctccatgtaa
     3841 cgctgtttat ccagatgcct tggtttgatg atctgtggat ccacatgctc ttgtatcgcc
     3901 agtacagagt caatgaagga ttccacagcc tttgaaccgt attccatttc atagctgttg
     3961 attcgatctg ctgtggccga catactctcc accatattgc gattagaagc tgaaaagcgg
     4021 gcgttgtgtt tgaaaaaatc acagtgtgcc agtacatggg cgacaatcag tttattttgc
     4081 accaaagaat ttccttccag caggaaggcg tagcagggat tggagttaat gaccagctca
     4141 tagattttgc tcaatccaaa atcgtactgc attttcatct tgtggaatgt ttttccaaaa
     4201 ctccagtggc tgaagcgcgt gggcatacca taggctccga acgtgtatac aatgtccgcc
     4261 ggacaaattt cataccgcat cgggtagtag tcgagcccga agccatctgc aatctccata
     4321 atttctgata tcgcatattc tagctccttc tggtcggtgc tcatcccacc gttccccctt
     4381 cccgtttgcg aaaaaaggta cgtaaggctt ggtatacctc acctttttcc ttgatgacat
     4441 agtacataaa ctgatccttt ttaatattct tgtaggctga catcagcgtg ctgctacgat
     4501 tatattgatt cacttctcca tagccgaaca tattgctccg ctttataagt tcctcgatta
     4561 gcttcacaca ccgctcattg tccgaggtca ggttatcgcc atccgaaaaa tggaagggat
     4621 aaatattgta gctggaagga ggatatcgtt tgtcgataat ttctagtgct ttcaaataag
     4681 cggaagagca gatcgtgcca ccactttctc cgcgggtaaa aaattcttct tccgtaacct
     4741 ctttagcctc ggtatgatgc gcgagaaaga caatttccac cttttcatac tgacggcgca
     4801 aaaagcgggt catccagaaa aagaagctgc gagcgcaata tttttcaaaa gagcccatcg
     4861 agcctgatgt atccatcatg gctataatca ccgcgttgga ttggggaatg gtcttctctt
     4921 cccatgtttt gtagcgaaga tcgtccggac taatatgatg aatgcccggt ttcccttcac
     4981 gggcgttgcg gcgcagattt tcgagaatgg ttcgtttctt gtcaatgttc gcttgcatgc
     5041 cttttttacg tatatcattg aacacaatag attcaacctc aatttgatcc ttgtcttttt
     5101 gctgtaaatt cggcaattcc atttcctcga acagcatatc ttccagttct tctatgctga
     5161 cttccgtttc cataatatcg tgtcccggct gatcgccggc tttctcacct ttaccaggct
     5221 tctgggaggc aggatcacgt ccgatgacat cccccacctg actatctcca tccccttgac
     5281 ctacatgctt ttgcttttga tagttataaa tgaagcgata ttcatccaga ctgcgaatcg
     5341 gcactttgat aatctgttga ccgtccgaca taataatatt ttcttccgtt atcagatcgg
     5401 gtagattttg cttaatgaca tctttgacct tctgctgatg acgttgctgg tcctggtacc
     5461 ctttgcgatg cagcgaccaa tcttcgcggg atacgacgaa tgaatatggc tggcgtggtt
     5521 ccggcattat taggcacccc ccaagtggat acacggcaca gtttggcctt gttggttatt
     5581 aagtatattc acggggatga acgatatgtg atggaactcg atttaaattc tgcccgtttg
     5641 cttttataat gaaagtaaaa aatgtaaaaa aagaatggag aaccttgggt tatggaagaa
     5701 attgcagtac ttatagtaga cgatgagcag gggttgcggg atatgctgac aacggtgtta
     5761 aaaaaagaag gattccttca agtcaagcat gctgcaacgg gtcgggaagc gctgcaagtc
     5821 gtgatggaat ctcatatgga tgtgattgta cttgatgtca tgctgcctga tagcgatggg
     5881 tttgaggtgt gtcgtcaaat gcgtctatat acggatgccc ctattctttt tttgacggca
     5941 agagatacag acctagacaa attaatgggg tttggtatcg gaggggacga ttatattacc
     6001 aaaccgttta acccgctgga agtcgttgcg cgtatgaaag ctcgaatgaa atatcggaaa
     6061 gtttcgacag tggccatgaa accgacctta cgcactttag attttggata ttttcgtctg
     6121 gagctggaat ccggtgtatt gtatgtggag ggaaaggagg tcgattgtcc ggcacgtgaa
     6181 tggctactgc tggttttttt gtgcaagcat cctaaccgga ttttcagtgt acggcagctt
     6241 tatgagacga tatggagcga ggccttcttg ggtgatgaga agaccgtagt gattcatatc
     6301 tcccgtttgc ggaaaaaaat agaacctgat cccaagcacc cgcaattttt aatcaatgta
     6361 agagggcttg gttataaaat gatgtcagtc aagatggggg agcaagaatg aactctctgg
     6421 ttaagatgtc ctttcgcttt atgaaagtaa cgttatgctt tgtactggcc tatgtcctat
     6481 gttttgttat ttgcacgatc ttatatattt ttataaaaag tatatttgga gcatctcaaa
     6541 atataaatat tgatctattc tggacaggac ttggtatcgt gcagagtgtt gtgttcatag
     6601 ctgcctatgg atggtatata ggcaaacctt tggtgtatgt aattaaatgg attggaaata
     6661 ttgcgacagg ggaattccaa gcgccgctaa gtgaactgga actgccagag ggcaaaaaaa
     6721 atcagaaaaa tagttataaa cctccgtatc aattgtataa agaagttttt gaacaaatga
     6781 acatcttatc ggctcaattg cgcagcaatg aggaagagag agtggaatta gagaaacgta
     6841 aacagcagtg ggtagcaggt gtaggccatg atctgaaaac accattatct tatattgaag
     6901 gatatgcggc tatgctaact gctcaagagt atgactggtc tgaggaagaa agaagaagct
     6961 ttagtatgag tatcagtgag aaagtgactg aaatgaagca gttgattcag gatttgaatg
     7021 cttctatgca gcttaaggaa agtccattgc caatccaatt ggagaaggag gacattgtgg
     7081 agtttctccg tagtacagtc atagatatcg ctaaccatcc ttcggctgag caatacgaat
     7141 tttcttttac gtcaatggag gcggcatgta tcatgccctt cgatagcaaa ttactaggca
     7201 gagcgctgca gaattttttg atcaacgcga tcattcataa tcctccaggt acacacgttt
     7261 ccatggaagt aagtaaagcg aacgataagc ttcatatttc tatcgaagat gacggaatag
     7321 gaatgaatcc caatgagtac atgcagatat ctcattccca aggacatgga atacctattg
     7381 ccaaaagctt tattgaggcg cataacggaa cgcttcatat cctttcaggc agtaaagcgg
     7441 gtactaggat ggagatttca ctgccgctaa acatctaact ttttaacatc taatctcaca
     7501 tttcgcagtt tgctcggttt tttttgcctg ttgtttaggg actgtttact tgatgtttac
     7561 tttacttcag taaactatat gtaacttaag cttcagcatt agaagtcgag aggagatcag
     7621 gaaatgtctg aatatgtaat acatacacag cagctaacta ggcgttttgg aaaacgggaa
     7681 tttgtaaaac gaataaatct ccaggtaccc ggacagcaga tttatggatt tttaggacct
     7741 aatggggcgg gtaaaacaac cacgattcgt atgctgcttg ggctgattaa atccacctcc
     7801 ggagaaattg agatttttgg gaaaaagctg aaggatcagc gtatggaaat attaaaggat
     7861 gttggttcct tggttgaatc acctgcctat tatgcccatt tatccgcata tcgaaattta
     7921 gaaatcgtta caaccatgcg tggactgccg acccgaagaa ttcatgaagt gctggattta
     7981 gtgagattag ccaaggatgc gtatcgtccg gtaaagggat attccttggg gatgcgacaa
     8041 agactgggga ttgctatggc gcttattgcc aaccccaaat tattgatact tgatgaaccg
     8101 acgaatggtt tggacccatc tggtattcag gaaattcggg agttaattat gagcctccct
     8161 ggtgcttacg gaatgacggt actggtttcg agccatttat taagcgaaat tgagcagatt
     8221 gcaacctatg taggaattat taatcagggt gaaatgatct tccagggaac gatgaaggaa
     8281 ctcaccgcca aaagcaagcc tcaattattc attgaaaccc cagatcctgt tctggctgcc
     8341 ggtgcactga ttcagcatgg gtggacggcc ggagctgaat cgattgaaca aaatgaggtc
     8401 gtgactccta ttgtagatcg gcaacaatct tcggagatga tcaaggtgct tgtggaacac
     8461 aatcatccca tttatcgggt cacagagaag aaaaaaacat tggaggagat attcctggaa
     8521 ctgacaggta aggagcgaag cttatgatac tccgggttat aaagtcagag gggcttaagc
     8581 tgaagaaaat atgctggtgg attcctctta tacaggggtg tgtacttaca ggcatgactg
     8641 ccgtggaatg gtatctttac tttcggcaag gaccaggagg tgtctatgct ggttttgccg
     8701 ttatgtttat gttcctttcg tttgtgatgc tgcttggcgg tacacttttg gcgagcatta
     8761 tggctggtac agagcatgat actcaaacat ggaagcagct tatggtcatg cctgttccca
     8821 gaagttatat ctatttatcc aaaattgtat ggatcgtgat tctgcagttg ggtaccgcct
     8881 tgatcactgt agcaggtatg agcctcatct gggtgttata tacaaacgaa cccattcctt
     8941 ggcggatcat gctgttacag ccgattaatg caagcttggc taccctacca gtacttgcaa
     9001 ttcaactttg gctgtctacg cttttcacta atcaggcatt cccattagcg tttggtatat
     9061 tcggttctat tgcaagcttg tttttggcac gcacaagtat tctgtggatt aaaatattgc
     9121 cttggtcgta ccctgcacta tcaagtcctc tgatgaagga acacatgatt tgggtgatcg
     9181 ttgctttaag cgcaggagtc atctttacgg gacttggtac actacagttt accaagcatg
     9241 aattcaaata gagaggagaa gatacatggg ctctatttta cgcgtggaga caataaagct
     9301 tcaatggatc atggtatgga ttctcattat attggatgcg gtcataaatt ctttaatggg
     9361 agtcctggaa ctgaatgatt tgaaacagtt tttttcgccc agttggttaa ctttatatac
     9421 ttattcagcg caatttcact ctatgttttt ttatccgctc tattgtggaa ttatcgcttc
     9481 tcttttgtgt gcgtacgagc atcgggatgg gggatggaag attttattaa gtagcccgta
     9541 tcctcgtcag caaatttatt atgcaaaata tatattgctc attctcatac tgggtctgga
     9601 tcagcttata tttatagcag gctattttgt aagtggaaat atagcaggtg ctccaggaga
     9661 aatcccttgg tctgtcgttc tttctaccgg tttgggaggg tggctcggga tttttcccct
     9721 ggcagcacta cagcttatgc tctcgataaa aattcggaat tttggagctt ctctgggaat
     9781 gtctatttgt tgtgtggttc ctaatattgt cataacaggc tttcactctt ccataggtgc
     9841 gtggtttcct tttacgattc cttattatat tatgatgccg caaacagcga cttatgcacc
     9901 cagagttgag ccttacagtc tcggactgat tgtcattttt acgtttttag cctatctgta
     9961 tggtggaaga aagatgtttg tgaatagaga ctggttgtag ttaggatagc atgaggatgt
    10021 aatcccaacc gatctctttg ttctcagaaa cacttaataa agcagctgca atcccagcaa
    10081 cgccttcaag catgcccgct tttgtcagcc aagttaaaga gccatctgac cttggctcgg
    10141 ggtccagata tccaagtggg ctatccattt gaaagcgatc aagcagacaa ttcgttaact
    10201 gttgaataag cgggaaaaac gcaggctctt tactgtgaca ccacattcgc caagagatgg
    10261 taagtaatcc ggcaagaccg tgacagagtg cagaagagtc catttcccgc ttagctatct
    10321 catgggagat tgcaccgaca caagctttca cagccaattt ttgcagttct tcattatgga
    10381 gagcctttcc ggcaagaaat agcgtacagg caatgccggg ggtaccgtaa caccatgctt
    10441 ctcttgctcg ttccaaatca aactgtagag agcctgtttc agcttcgaat ggaacaatat
    10501 gaggccagta gctaccatat tcatcttcat atttatactt aagcaaccat tccgcaatgg
    10561 tttcaatcgc ttgatattgg ccttttactt caattccagc actgtaagct acagataata
    10621 aagccaacgg tccaggaata ccgtgtgcca ttccacaatt aaaattgccc agaggatagt
    10681 tacgtttatc ccggtctaaa aattgaaact tttgcgggga gtaccaccct gggacataac
    10741 gattgtgaat atgtatggga tgtgtaagat cggtaagaaa ttgaagaatt ggctcaacaa
    10801 gaggagtaca gataggatcg gttgagttca tcaaaatata tcttccaatc cctgaagctc
    10861 ccgaaatggt gtcaaaggct tgcatgggca taccttcgtg aaggcttaat tgttctgtgt
    10921 tcgactgaag ccattgctct gtaagaggca tcatccattg atgtatttgc tgtaagaaat
    10981 tactgtagta tttcccatga ttagaagcct ctcttacgga cgaagcgatg cctgcccagc
    11041 cactgtaaag agagagatcg tgaagaccat ttttagagag tgaggattga atctgagcca
    11101 tgtttgaatg tatggctgta ttccaatcat acgaagggtc tgtagcacgc cattgcgata
    11161 gtaaatgaat gttaccagga taaccatgcg aaagtgaagt ttctccccat gggtggtact
    11221 ttgtttctgg cgaaacattg tgttccgatc ggactgctgc atagacggat tcgggctcgc
    11281 atagacgtaa agcaattttt ttactaatat ctcttgcacg aacttggtcg gattgttgta
    11341 taacaaaact atcaattttc atatgaaagc ctccattatt tttttcttca ttatattgtc
    11401 actaaaatct agtgtgttgt ccttaaaaat actgaaaaat aatgaaggtt tatcttaaat
    11461 gtactcgttg aaattaagaa aaatgtaaga attatataaa gtctagttaa gattatataa
    11521 cttataataa aaatgtaaaa aataaaagga ggtaacaaga tgaaaaatca atttgatctg
    11581 gacttgcaag tagctaaaga tgaggttgct tcaaaagggg ttcaaccagc cagtggtatt
    11641 atctgtactc cttcatgtgc aacaggtact ttgaattgtc aagttagtct taccttctgc
    11701 aaaacgtgtt aataacgaaa atacatggaa aaaaggcacg gtttctataa ccgtgtcttt
    11761 tccagttatg aaaatgaggg aaggatttat ggttgaagat ttgaagggga gatcagttga
    11821 aatcagtaag tatatagcac aaaagctaat agacctatca tatacagaaa agatagttaa
    11881 tcatacaaac aacctttcac cttcacgtgg aaatccccct tggaatcccg gctcgcttgc
    11941 cgatggaatt ccgggtgtgt ttgcgctgtt gtccgaatgg ggttacctgg agccagatca
    12001 aaattgggca gagcatgtgc atagtcagtt acggtactta gatgctaact ctctattatt
    12061 attgcctcgt atttctcttt attatggaac aacaggagta gcttatggca tattattagc
    12121 ttccaataac agagctaatt ataacaaact aatctctcag cttaataagt atattgaagt
    12181 aaagtggggg gatttacctg taattggcac aattacagag ttcagtaggc aaatggatat
    12241 cattaatggg ctgctcgggg tgggcagata cactctggag gttgctgaag acaagacgat
    12301 gtgtgatctg tctcgtcaat tattagacac cattacgcac ttcatacctg aatatataca
    12361 tttatcgtca agggaagatt cggcttcaat cgatctaggt ttggcgcatg gtatcaccgg
    12421 aatacttgca ctgcttgtca ctgccctaca aaaaaagatc aaagttgaag gactacatga
    12481 ggctataaaa catatagccg attttttgct tattcaaatt caggaggatc aatatggctg
    12541 gtattggcct gtaaactctc aagcatcttc aatgaacaag agagagaaaa aagtagggat
    12601 gagagaaatt gaaggctggt gtcatggaac ctttggaata gcttggacat tactcagagc
    12661 aggaattgag tgcagtaatg aagaatggaa aaagatagcg gaaaaagcta tggaatccat
    12721 attttgctta gatgatgagc tactaaacgc gctatcccct actttctgtc acgggttggc
    12781 tggtttgctt catatggccc atagattctc tagcttaacc gataatatag cagcgttacg
    12841 ctttgccgat cagatagctt taaggttagt aaatttatac gatgaagaac tcccatttgg
    12901 ataccaggat ttggagggga caactcatgt tcataatgta ggaatactac aaggagcaac
    12961 agggattgca ttaagtttgc tggactatgg aattgggaaa gaacatccta aatattcagg
    13021 gagatggagt gaattgtttc taatttctta agggtgctac cttattgctt tatctgaagc
    13081 attggttttg gagggattag atgaaacaaa aatttatggt tatatcatct tttaggaaga
    13141 tcaagcattt ttttgagact ttaagcactc cagaaaacat tcaaatcatg ttttatgatt
    13201 cgctttacca ggctataacg gagattgatg agcagtgtat cggtgtagct ttgaatcagg
    13261 atcatataac actagaggac ttgtcttact ggcacagcat taaagaaaaa tttaaggttc
    13321 catttatctt tctttcctat catagtgatg accaacagca attggatctc ctcaaacaac
    13381 tgttttcaat ggcatcatct aaatatggaa tggaaagaga acagcaggct attagtttat
    13441 cacccaatgt catttttgat cctgctggaa aggttatttg gaagcaaggg catgagcata
    13501 tgctgactat gatggaattt cgattattaa tgtatcttct tactgcaaaa gagtgtgctt
    13561 ctacaattga tcacattata gacagagtct ggggagtgga tgcttttact acgtctaata
    13621 cggtgtatgt gcacatccga aaattgagag agaaaataga agatgatcca agtcatccaa
    13681 aaattctggt aacatgtcat ggaatcggtt acaagttgaa tatatttcct aaaaacttgg
    13741 aggtggtcag ttgtgaagag acaactgcat tacactgatg cgcataaact acataatgaa
    13801 gtgagagatc gggatgaaag atggtttagt gcatgtgatt tttttctaat cagagctcca
    13861 ttactatcgc tagaccaata ttttcaggtg ttttcggatc aagatgtgga cagccagctt
    13921 actttggagg aaataactcg tcgattaaag ttgatatccc aagaagctgt tgttcaagaa
    13981 gccatatcat tagcctctcc gtccctaatg cagtttctac attacttgaa tgatggtcat
    14041 gctttggatg ataaaggaga gctacaaaag tatgagaaga cgctgaacag cttttatcgt
    14101 tattttattc ggatgactac ccgaacgact ccatttgggt tattttcagg agtggggcag
    14161 gggatttgcg ggaagactac cgatctggat attggtagct atcctaagca tctgaagaga
    14221 gccagacccg acatggaatg gatatataaa ctgattcaaa aaatagaagc tgatccagcc
    14281 atatttaatc aacttaaggt cttcctaaac aaaacggtta tgatcaaagg aaatcgagcc
    14341 aaattaccat tccgacctaa gcatggagca gcagaagctg atgattcggc agaaattttt
    14401 aattccattc ggcttactga cgttgttcga atgacgtttg aagctgcgga acatcccatt
    14461 cgggtgatgg aactcaaaga aatactatta aaggcattcc ctgacgctac tttggaaatc
    14521 atagctgatt atttgcagca actagtagag caagagttta ttctgagcga gcttagacct
    14581 ccgttaatgg atcattcacc ctttcattac atattcgaaa aaattaaaaa actggacatt
    14641 tccgatcctt ggattcacat tttacacgaa attgatgctt tattacttca atataatcag
    14701 tgcacgattg gagaaggaga gaaggtctac cggaaattat gtgacaaaat gctggatatc
    14761 atttctgtaa aaacacctgt acaagttgat gttaaattgg ataaagaagt aacgctgccg
    14821 aaacatgtgc ttgatgaggt ttcattaggg gctgaagtca tgtgcaaatt gtatgcatcc
    14881 cccaaaacgg acgaattgga tgaatatttg aatcgtttct tggaaaagta cggtgtgtat
    14941 caggaggttc ctattcatga actgtttgat gaggattggg gtttgggtat accggaaatg
    15001 tatcgttcaa atgaaaaaaa atcaatgggc atggaggctt ttaaacgcaa cgctgttctc
    15061 tttcaatggg tttcggatgc catttctaat catgaaatag aactcgccct tacagatgaa
    15121 caattagagc aactgatgat ttctgataac tacgacactt ccccagaatc aatggagatt
    15181 tattacagta tatttgctga ttctcctgaa aaagttgatt ctggagacta ttcgctttta
    15241 cttggagcca gtgctggctc gaatagagcg ggtaaaacct ttggacgttt tctggatatg
    15301 ttgagtgagg agtttgtaca aaaattctct gaaatatatg atcatcaccg atgctttcat
    15361 cccgatgcgt tattgtcaga gatggttttt atgccggaac aggggaaaat atcaaatatc
    15421 tcattaagca aaaatttaat ggcatatgag attgtgtcgg gaaccacctc ttctaaagat
    15481 gaggaccata cgctctgtat tgatgattta gtggtgggtg ctactcatga tcgtttttat
    15541 gtcaagtcca gacgtttggg taaggaaata atccccttgc aaacacacat gctgaattac
    15601 aagctttcac cacatatatt cagatttcta acggatatta ccaataaaga gattggtacg
    15661 tggtcttatt ttgactgggg gccattagag caatcccctt ttttgccaag actagtatat
    15721 aaaaagatca ttattagtgc tgcgcagtgg aaactgagca aagcttcatt gaatatttca
    15781 gaatcatgcg agtccaaaga aggagaagaa cttttccatg tgtggagaca acaatggaat
    15841 gtaccgcgtt atgtttacct aacgatgggg gataatcgcc ttttattaga cctatgcaac
    15901 cttttccata tcaaagaatt gctacatgag gtgagcaaga cacgtgaagg acaggaactt
    15961 cttcttaccg agtgtttggg taatcccttc cataccccag tacaggggac ggcaggaaga
    16021 tatatgggag aatttgtgtt tccactaaag aagaaaaaaa taaaggtgaa accgagtatc
    16081 cctagttcac aaaaccatat tgtttctcaa aacttcatta ctcatactcc ttccagcatt
    16141 catagaggca tatttccagg aggggagtgg ctatacctta aattgtacgg agtcaaggaa
    16201 agagagactg acctggtagg cttaagccta gggcatctct taaaacagcc ggggtttaag
    16261 gattggagtc aaaaatttta ctttttgcga tacgttgatc ctgagcatca tatccgttta
    16321 cgttttcggg gagagcccga taagctatgg acagctggtt tggcgcaatt aaatcagtgg
    16381 gcagccgagt tacgtgaaga ggggctaata acgaatatgg tcatagatac ataccatcct
    16441 gaattggaga ggtatggagg acagacactt atggagctgg cagaacaggt ttttgacgtg
    16501 gatagtcaat gggtcatcac ctatatgaag ggaattcgct ctaatgcttt caatctggac
    16561 atagagattg tggctgtgat gaacattatt cattatctga gtggttttgg tttaacgatt
    16621 caggagcaag tgaaatggct agaagagaga attgattgca agcctcatat gaaggcattt
    16681 agggatgtca aaaaaacatt gattaccgct gtagagtcga attatgaatg gattggacaa
    16741 gcagatacga acacacaggt tgctttctta gcgcttgtag aaaaaagaca gactatgatt
    16801 cagaagtatg ctcaagcgat aatcctggct aaaaataatc acgaacttac caatcatcct
    16861 gatgatattt taggcagtat cattcatatg catttgaatc gtttgcttgg tgtaaatagg
    16921 gagcgagaaa taaaatgtat ggctttagct aagcatacag tagctaacct gttgcatagg
    16981 aaaggggtaa gctatgtcac agtctgatgg acaaaccaat gacctgatct ctttgtccta
    17041 taaaaatata tttcgtacct ttttattttg gcctcgtata ttcaggctgc tttgggacac
    17101 acatccttcc tttttgattg ctatactcat tacgaattta ttgaagggcg caattcctgc
    17161 tgtgatcctt ttaactacga gagaattaat caacagtgtc gtggccggag cgtcaggagg
    17221 aagctttcaa cctgttttta tagcttttgg cgtcttgatc ggtgtcaatt tgctgtacga
    17281 tctgatcaat attggcgaaa gcttttttcg taaaatgttt caaagccggc tatcgaacca
    17341 ggtaaatatc agaattattg aaaaagcaca aaagatgtct ttgcagtcgt ttgaggatgc
    17401 agatgtgcaa aatatgctcc aacgtgctca gggagaggcg gattttaggc cgtttgaaat
    17461 atttactcaa attcttgcca ttattagcag tgttgtaacc ttattctcga cgggtgctat
    17521 tctcatcgca tggagatggt gggcgttctt attcattttt ctcattccat gcttatcatt
    17581 ttattctttt ttacgtatcg gacaaagaga atttaatgtt cactttcaaa gagcaggaag
    17641 acaacgtgaa tcctggtatt tgtcgttttt agtgacaaga gataatagtt ttaaagaagt
    17701 gaaaatattt caattgggag actatctgcg aaaaagatac aaaacgatac tcgaagggtt
    17761 ttatcgcgag gataaagtgc tagcagttcg tagatcctat acttctcttg tatttcagat
    17821 tgtaaatcag ggtgcgtgtg catttattat tttcatggcc atacaagcca cttatgttgg
    17881 tcaaatttta gtggggaact tggtgagctt aattcagggt atcacgttaa cccagtcaac
    17941 atcgcagagc attgtacaag ggattttaag cttgtgtcaa aataatttgt atatcaagca
    18001 gctatttgac tttttggata tgccggaaga ggcaaaaata caaaaatcag ttcagcaatt
    18061 gcctttgtcc gctattcaca gtattgaatt tcggaatgta tcgtttagat atccgaacac
    18121 ggaggagaat gccatttcta atgttagctt caagcttcat caaggagaga agctggccat
    18181 tgtagggaaa aatggatcgg gtaaatcaac aattgtgaag ttaatgactc atttgtattc
    18241 cgattttgaa ggagaaatct taattaatgg acactctata catgaattgg ataaagacag
    18301 ttttagagaa aaaataggcg ttgtttttca ggattttgta cattatgaga tggctgttag
    18361 agataatata ggctttggta atgtggcttc cagagaaaat gatgaggcta tttggacagc
    18421 tatagataag gcgggaatca cagatttgat agtcggcctg cctgataaaa taaatagctt
    18481 gcttggaaaa tggtttgaag atggacagca gctatctgga ggacaatggc agcgtattgc
    18541 aatagctagg gcttttatga gaaatgccga tatatatgtc ttggatgaac cgagctcttt
    18601 tttggatcca cacgcggaga aagaggtttt tcaaaagttt gatcagctta ttcatgagaa
    18661 aattggagtg tttatttcac acagattgtc ctctgcacgt atggccgata tcattatttt
    18721 aatggaggag ggtagaattg tagaagcagg tagccatgaa cgcttaatgg atatagacgg
    18781 agtgtatgca gaaatgttca ggctccaagc ctcctcgtat ctttcacaac gagaacgtgg
    18841 ttttgaggaa gaaaatctgt cgccctcgtt agtaaggacg acaggtggat cataagaaag
    18901 gacagatgcc ctcctattgt aggagggtaa tttttatctt caccacaaaa gtcgaactac
    18961 agccatactc acaataccga caacgacggt agccagcagg tttttgctcc acaaggcggt
    19021 cactagcgta ggaagaacag ccataagcac ttgcccatta agagtgactg aggtctcggt
    19081 tcgaacgagc agattttcca tcacgagggc cgtgaatatg cagatgggaa tataggaaag
    19141 ccattgtagc actggcttgg gtagcgccag cctttgcagc acgacaaagg gaatgatcct
    19201 tggaatcgcc gtgacaatca tggcactgat aatgatatac aggacattgg gattaatgtt
    19261 catttgtcgg ttaacactcc aatcgttgcg gtgatcatgg tcgctataat gacggcgata
    19321 tgtgatggca cccaccaggc caaaaggtac atcagaacag ccatacatag cacaagcagc
    19381 agacgatgct tgagtttgga ggtctggata ctttggagct gggaaatgag taaggcaaga
    19441 aacatcgcag gcaaggcaaa gtccagacca aaagcctccg gtcgggaaat ccagttcccg
    19501 agaacccctc ccgccacaca ggatgcaatc caggcgagat aagctgtaat attaagcccg
    19561 ttcatccagc ggtcactgac ctgcccgcct ttagccaatt tatccgatgc tactccaaag
    19621 gattcgtccg tcaaaagaac accgatgcct atgtttttcc acaatgaata tttagaaaag
    19681 taaggagcca gcgatgcact taatagcagg tgacgagcat tcacaatgaa agtcgttaaa
    19741 ataatgacgg atggaggact ggctgcagcc agcatcgagc acataataaa ctgggaggct
    19801 cctgcgtata caagcgccga catgaaggca atttccatgg tgctaacccc tgatgaggca
    19861 cccacaatgc ctgccgcgaa cccaatacat acataaccga gcaatgtagg aatacaatct
    19921 ttaacccctt gtaaaaagct gagtgaatcg tgcttcgttc cgctcaactc cgaagctatg
    19981 gacattttaa ccttaccccc agtgtataaa ttttataata gtatataacg taaattgtaa
    20041 agcatcaata tattatacgt ttgtatgtta tattgaatag ttcctacagg agaattgctc
    20101 ttaaaaagct gttttactgt tgacaaccca atgaaggcta tgtatttacc aataaggttc
    20161 ggtcgtgttc cggttccaga cgatttggca gcagctagtc atccaaaagc ggtgttcaaa
    20221 tgtactcccg ataagctctt cgaaatggca aacgggcaag aaatgatgat gaatcaaagc
    20281 agctcggatg tgttcataca agggctgttt tgactgaatg gggaactcgt aaaaaaaggg
    20341 cgtcccagtc agttcatgac tcatgggaca accctaaggt ggtgatttat ataagctcct
    20401 gccgcttttt tagatatccg tagagaataa ttcccgagat cgcgcagatg gctgcgcata
    20461 gaccgataac tccataaccc gcctgaagcc cgcgcagtat gccaagctca gtggttgcgc
    20521 cgtagactat cttgacccct tcgattaccc agccgatcac atagttgcca atgacactac
    20581 ctatgcccat cagcgtgacg acgaacgtaa tagctgtatc actgtccttc ggatatctcc
    20641 ttgctatgaa cgccatcacg gtcggataga tcattgcaat acctgcaccc gatacggcaa
    20701 agagaaacgc cagtctctct ccacccgcga ttgctgcgaa cgtacatatc gctgagaagg
    20761 cggagaatag aatcgtcgaa agcacgaacc ccatccggtc tgtgagcgga ccaagcaaca
    20821 ggcgccccaa cgagaaggta agaaagaacg ctgagagcat gctggacgcc ttcaccgtgc
    20881 tccatgaata cgctttctct aaaaagttga ccagccagcc cccaactgcg agctcagaga
    20941 ctactccaaa cgacaggatc attaccatca tccagagtgc tggatcgcgg gttagcgtct
    21001 tgagtgaggt tcgatcctca tgctgcaaat cgtctcccgg gaaggtgctg agcagtgcgg
    21061 ccacaatcgg cagcaggcag agcgacaaca tagccagata catcccccgc cagtccagca
    21121 tatgtccaaa taccgtcagt gacatgactc ccgtcgccag caaaggggcg actgttgagc
    21181 tgagcccata gaaaaagtgg gacaaattca tcatcgtgcc ggtatttttc acaaaaatcc
    21241 tcgcccccaa aattgcgagc gcaatctcca gcatgccgtt cccgatatac atcaagaagt
    21301 aagacgaggc gaagaacgga tatgtgtgcg acagatagat gaacactccc gagatgatca
    21361 tggaagcaaa ggaaatgatg ctgaccgcct tgattcccca cttccggaca aggacagcgg
    21421 tgaacgagca ggcaatcaaa taaccaagtg cgtttagaga caacaatgtt cctagctgct
    21481 gttcatccag attgaagtcg aattggatgc gtggaatggc agggccttta atattttccg
    21541 agatgccaaa tacaataaag ccaataaaaa ttgtcgccag ctgcattgta tacatgtggt
    21601 gggacttgcg ggtttgcaga ttcaaattta atccctccta gatagccaaa cttgattttc
    21661 tcacctgttg ggtgttcagg gacggaaaag tcataggata gcagccctcc ttcaggatat
    21721 tacaatagtt ttgaaaaaag ttttaataag tgaaaagttt aaggacattt atattcaatg
    21781 tcaatgtttt tattgcatgt tgaagtaagc gaggaacctg accatattac agtaaattgt
    21841 agcatgtcta cttcccgttt aagctttgta ttaccttgat cggctacact taatttactg
    21901 tggagaataa gtcgtgcatc caaaattgca aaagataaat gatattttac gatacagtct
    21961 atatatagcg aacacacagt cttttgtgta ttcttcttat atagactttt ggatacaagg
    22021 aggcatcgtc cgtggattca atgcagcata ttattggctc taatttggct caaatcagga
    22081 agactagagg attaagtttg gataaggtgg ctgaactgac aggagtcagc aaagggatgc
    22141 tggctcagat tgagaagggg aaatccaatc ctacggtaac aaccctttgg aaaattgcga
    22201 acggtctgca cgtatccttc tccacctttc ttaaagaaga tccgccgcaa attacgaaga
    22261 ttcggaggga agacctgcat ccggttattg atgaggacgg taattatttt gtttaccctg
    22321 tattcccgta tcacgctgaa aagaagtttg aggtgttcac ggtaagtctg aagccaggct
    22381 ttacacacca ggcagagaag catttgggag aggaaacgat tctcatgatc cgtggggaaa
    22441 tgtactttga aatgcagggg caacagctca agctgagtgc aggggatgcc gtgcaatttc
    22501 aagtatctga catacatacc taccggaatg attcggatga ggatgccgat ttttatgtat
    22561 tgatttatta tgcggattag tgggatgatt agtatagtct aaaacaggct tccacatcag
    22621 gattttgcaa aatcataaga tataaaaaga gagcaacgag gaaaagagag gaaagaaccc
    22681 atggaaagca agtacatccg agaaacctac tgcttcaaga cgtcccgagt atttcccaac
    22741 gatatcaaca atcataacac gctcttcggc ggcaggctga tgtcgtatat cgacgatatc
    22801 gcatctattg cagctgctaa gctgtgtcgt acgaacacgg ttacagcctc tacggattcg
    22861 gtggattttt tgctacctat ccatccgagt gattctgtca cgctagaagc gttcgtaacc
    22921 tggacaggcc gcagctcgat ggaagtgttc gtaaaggtaa ttcgtgaagg actgatgact
    22981 ggcgatcgga aaatcgcagc caccgccttc ctgacctttg tggcattgga cgagaacaac
    23041 cgtaaagtga ccgtcccgca ggtgattcca gaaacagaag agcagttaca attgcaccag
    23101 acggctccat cacgcgcagc catacggcgt cagcggaggg aagaaagcaa gcagctggct
    23161 agttttctga caacagatta tccgtgggaa ctgtaacgta ctagagatta tcaatttcat
    23221 cgttttacgt aaaaaggagc cgtcttttcc gttagcagtc accatgatct gctcggaata
    23281 cggctccttt tgaaaataac ttgagttatt ctactttaac tacacggaaa tgctgattcg
    23341 tcccaccatt atcgccccat tgaatggctt tggctccatc ggcggtggcg ccttcagaaa
    23401 tatcgatcag cttgccggtt gcccgatttt tcagcttgta ataaccaccg gttacggata
    23461 ctaattgcca atgctgactg gaccagcctc cgtcactcca ctgctcaata actgtaccgt
    23521 ctgttgtggt accgctttca acgccaatta gctttccgct gttgcggttc acaattttat
    23581 aatatccgct gtctgcatcc ttgagctgcc attgctggtt tgctgctccg gaatttacac
    23641 gctgctccag gtctgcgccg tccgtcgttg cattgccaat aatgcttagt ggcttattgc
    23701 tcttgcgatt cactagctga taataggcat tcggatcaat ggcaattggc gttgttatcc
    23761 cctcgaccac accactggcg gtgtcaatgt taatgctgtc gaaccaatcc atggctaatg
    23821 aagtcgctgt tggaaaacgc agtggcaacc atacatattg agaatcctgc acaggaccgc
    23881 tccacgcacc cgcccaacgg tcgcccaaat acaggtatga agtcgtctgg gcaccttcaa
    23941 caggaatcac gtaagctgac tgtgaaccat aagtcgtact gtccccgaag tttatcgtat
    24001 tactccaggt tccttcaatg ctggatgcgg tagcatactt ggcttgattg ggattccagc
    24061 cggttgcccc ggatgtaatc aggaagtaga cgtctccttt tttgaacatc gccggagctt
    24121 cacgatattg tcctggccaa agtgtagtta ccagtgattc aacttgcaga aaatccggtg
    24181 tcagacgata aatgttcaga tccgcgttta cccgggtagc cgaaatcagg taagctgtac
    24241 cgttatcgtt gtagacggtc atatcgcgcg aatcgtaatc cagaggacgg aagctgccct
    24301 gatacgtgta atcgccgtcc acggtatcgg aagaagcaac agccactcgg gcctcgttgt
    24361 aattaacccc attctcctta tgcatccata atacgtattt acgtgttttt tcattgtaaa
    24421 tcactttcgg acgttcaata ttcgaaacat tcagctccac agcggagctg ctggtcagta
    24481 catttttacg aaactcccag ttttttaaat cagaggaacg gtaggcggat accgccttga
    24541 acgtgccgtt gggattacga ttttcaccaa accaataata gtaaccgtct actttaatca
    24601 taccgccccc atgggcatgg accacgtttc catctgtatc tttaaactga atgccattta
    24661 caacattcgc tgaagcggct gaagcgacct taggtgaaaa catctgaaaa atgctcaacg
    24721 tcagcaaaat agagagcata atacacagca agcgggcaaa atcatatttc attgtttcgt
    24781 cctcctctgc atgcgttatt ttaaagcgct ttcattaata ggctctatga agtagtttta
    24841 atagagatgc ttatcccaat tgtatccata ttgaattgaa agtgctagag tagtatattg
    24901 accatgtaca cggcacacgc catccatatc taacagactt catcgaacgg tgagtgttac
    24961 aaactggctg atattcatta gatatacagg aggcaaccat gaaaatatac gcgattgata
    25021 cgagcaagcc ggaagctgag gagcattacg aattactggt aaatcgggtt tcgctggaaa
    25081 agcagcacaa gttagatcgt tttttacatc gggaagatgc tttgaggggc ttatatgccg
    25141 atgtgctgct aagatggttg gcctgccggc aattgaaggt atctaatgct agtcttcaat
    25201 ttacatacaa tgcgttcggt aagccttcct tgataaatgc acccgcattc cattttaatg
    25261 tttctcactc gggaaaatgg gtggtatgcg ctattgatga tcacccgctt ggaatcgaca
    25321 ttgaacagct ccgtcctatt gattttgagg taggtagagt gtgcttttcg gacacagagt
    25381 atgatgcgtt aatgcgtcag gacgcagaca gccgattgtc ctacttttac gatctatgga
    25441 cgcttaaaga aagctttgtg aaggccgagg ggcagggact aaccctaccg ttgaagtctt
    25501 tttcattcga gctgaaggca caaccgttca taggcttcac gacagagggc tttaccaccg
    25561 agtattgtca ttttaagcag tatgagctgg atcaggatta taaaatggct gtctgtgcag
    25621 ctcatgacca atttgcccag caggtgcagc agttagatat aaatacacta cgcttggaag
    25681 tggcaacaca ggcgtaatat gaagtggata tgcgtatagt tgaaaaaagg agatgagtgg
    25741 cgttgacatt cgttttgttc aagcacggcc ggttgtatgg ggagtgggct tccaaaggag
    25801 actccatcgt tgtacagcag ggtcggatac aagccatcgg gtatgctcgg gagcttgaat
    25861 tgcagttgac cggtaaggaa tatgaaactg tggattggga agacgcctat gtactgccag
    25921 gcttaaccga ttcacatatg catttgtcta tgcatggtat gaagctggct atgctggatt
    25981 taacatcagc tacctccaag gaagagatgc tggctatgct gcgcaaacgg gtcgctgtaa
    26041 caccgccggg agagtggatt ttaggactca actggaatga aaatgcgttt attcctgttg
    26101 aaattccagg tatagccgag ctggatgcca ttacagatca gcatccggta tatctcactc
    26161 gtacgtgctt tcatacgttc ttggccaatt cagaggcatt tcggcgtgca ggtattagcg
    26221 aggacacccc tgacccggct tcgggagcct atggacgaga cgcagatgga cggttgaacg
    26281 gattaattta tgaggaagca tcctttgcct ttactagcgt gcagccagag ccggattatt
    26341 cggttaagaa ggacacgatt cggcgggctt gcctggatgc gctacggctt ggtctggctg
    26401 ctgcacacac ggaagattta cgttttttag gcagcgtgga gacgatgcag cgaatttaca
    26461 gggagctgag ggaagaaggt cttgtttttc gcacacacca gctcatctat catccattta
    26521 tggaggaagc gaaagtgcaa gggctgcgtg caggtaccgg aaatgaatgg tttaaaatcg
    26581 gtgcgattaa aatgtttgcc gatggcgcta ttggtggaag aacggcatta ttgtctgaac
    26641 cttatagtga tgctccacat acctgcggaa tggcgattca accgcagcca gagctgaatc
    26701 agatggtggc agctgccagg accgcaggct ttccggtggc tgtacatgct ataggggatg
    26761 gggcagcgca catgatcctg acagcgatgg aggcccatgt gctcacggag gaaagcggtt
    26821 tgccagatcg tctgatccat ggacaggtgc ttagaaggga tttggtcaag agaatggtga
    26881 agctgccgct gattgcggac atccagcccc gttttgtcgc aagtgacttc ccttgggtac
    26941 tggatcgggt ggggaaagaa aggactgaat atttatatgc ctggaaaaag ctactggaag
    27001 caggcat
//
