LOCUS       NZ_MNPQ01000030        15925 bp    DNA     linear   CON 11-AUG-2024
DEFINITION  Streptomyces albidoflavus strain OsiLf-2 Scaffold26_1, whole genome
            shotgun sequence.
ACCESSION   NZ_MNPQ01000030
VERSION     NZ_MNPQ01000030.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 68700)
  AUTHORS   Zhu,Y., Zeng,X., Zeng,J. and Liu,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) College of Biology, Hunan University, 1
            Denggao Road, Changsha, Hunan 410082, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. FEBRUARY-2016
            Genome Coverage                   :: 140.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001865795.1-RS_2024_08_11
            Annotation Date                   :: 08/11/2024 02:37:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,098
            CDSs (total)                      :: 6,022
            Genes (coding)                    :: 5,927
            CDSs (with protein)               :: 5,927
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 44 of 95
            Pseudo Genes (incomplete)         :: 58 of 95
            Pseudo Genes (internal stop)      :: 9 of 95
            Pseudo Genes (multiple problems)  :: 15 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:10:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 15925
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MNPQ01000030.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15925
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..15925
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15925
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[3342:5925](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3343..5925
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            231..1214
                     /locus_tag="BGV78_RS28310"
     CDS             231..1214
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894518.1"
                     /locus_tag="BGV78_RS28310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="WP_071339408.1"
                     /transl_table=11
                     /translation="MQPPATPVPQEPDQAPEVAGRREGTPHLRGDLRAAVPDASAAVGV
                     TAAVFVFLWYRMEAGTSSTAAVMPFMDDPRAYWMYLLSQAFGWSALLWAWGTVMLGLVL
                     SGPRTARQPPRRTLERWHRTTSLTTTALMFAHALMFAAELVRHDTRPAWLTRLWSAFAD
                     SFVPGWYDSGTGQIAIPIGQAALYLAVPLGLLFYVRHRIGPRTWRRLHRFVLAVYVLSV
                     WHTLLYGTNVWYGEWPRTVLWLLQIPVALLLVVRLARPARRAERLGAPGRPGGPGLPEW
                     TARALGRLAAAAVVAGILAVVVSGHDGGRTRPADPPASTPHDHGSG"
     gene            1321..2649
                     /locus_tag="BGV78_RS28315"
     CDS             1321..2649
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640258.1"
                     /locus_tag="BGV78_RS28315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_071339409.1"
                     /transl_table=11
                     /translation="MAGETEFPEGARADGLPAALSDPARLAAVRGTGLLDTGPEPVFED
                     LATLAARITGAGRAFVTLVDEERSYWKSCVGVDVTGGRENPVRESFCYFLVGFGGDPFT
                     VEDAAHDPRTRDHPGIGPMKIGAWAGYPLLSPEGEVLGSFCVVDESPRTWTEADRATLA
                     TLSRSASAEIHLRQSLAASQHAHRLSADLAHTLQRGLLPPALRPVPGLDAAAAYVPASA
                     SAHHDVTVGGDFYDLFHAAGPYYGAFLGDVCGKGVEAAQVTSMARYTLRADAGEVLSPA
                     RLLTRLNTAMLTQEAPLFLTAVHATFRRTRAGAAGRVCLAGHPRPLVRRADGRVREMGR
                     PGTLLGVMEDVDLADTRFRLGPGDLLLLYSDGAYEARPAPGAPPEATREPFGEADLHAT
                     LAATHGLDAAATVDRITGALAGHHGGWASDDTALLALRVPERD"
     misc_feature    complement(1329..1343)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.61"
                     /tool="antismash"
     gene            2717..3346
                     /locus_tag="BGV78_RS28320"
     CDS             2717..3346
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468731.1"
                     /locus_tag="BGV78_RS28320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_071339410.1"
                     /transl_table=11
                     /translation="MTTTTPVLRLRDVHKRYGPRTVLKGADLDAAPGRLIGVVGENGAG
                     KSTLLRILAGELRADRGTVRLPATVGHCPQTVVLHHALTVAQHLRYFQVAYGLPEPTRA
                     WELLEELRFAAGPRDRTGTLSGGTRQKLNLAVALMHDPELLLLDEPYQGFDWETYLRFW
                     EIARSLCERGRTVLVVSHMAHDADRLDALHRLAGGRLTPVHDGGRA"
     gene            3343..5925
                     /gene="uppS"
                     /locus_tag="BGV78_RS28325"
     CDS             3343..5925
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894521.1"
                     /locus_tag="BGV78_RS28325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_071339411.1"
                     /sec_met_domain="phytoene_synt (E-value: 7.6e-32, bitscore:
                     102.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.7e-23,
                     bitscore: 74.5, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLRLCLATALRYAVLEQVRNRLALALAVFFVPVWVGLAYTAMP
                     TAPVRFFLRAADQDVTVAGNVLTQLSGAVHALALIVGFMMFLAARRSAAFDHRLVTAGY
                     PRACLVLAKYLALLLACLLVAGYATAWICVFWRPEQPVLLAAALGAGALTYGGAGIMLA
                     ALLRSELAGMFLVIMASFVDVSLQNPIANAGADSPVLRWLPTYGAMQSAVVAADTRHLP
                     WAHLGLALLWALTTAAVGTAAFTLHTRSRLGALHRTWRLPPLRHRVYRRAGVNDPELRA
                     GYETCRRLVRRSGQTDYAVTQLVPAPLRPLLWAMYGHGRVLDDLSDSGRTDAAERIDAW
                     VRAMEEDLARGTSTDPVRRALTHAVTTWDLPTGQLPASFATYRRDAAERPGFTSWEQWH
                     AYWHALSFPVGVTRLATLLGEATGTRLGPRDAEALRRWTDAFNLVDALRDLRQDAHLGR
                     VALPLPVLAAHGVTLADLRTARRTPQLHALVRELAVTARGWLDDADGLADRHPALAASW
                     RTLIRLQRLQLRALERGRPRSGGRRGTGRLRRALVLHTGRLHAALNWRRLGPVLTPPQG
                     ARVPAPPPPLTPVVPRPRPAEPPLPPRPHAGGARPPAGLGDRVPRHVAIIMDGNGRWAA
                     ERGLPRPRGHAAGQSALRDVVYGALELGIPHLTLYGLSTENWKRPAAEVEEILRLLGEG
                     ADADREEVFARDVRLWWSGLPEGLPAGLLDALESTVRRTAHRRGLTLTLCVNYGGRAEI
                     TAAARKLAGDVAGGGVHPSAVTAPLFARYLHRPALPDVDLLIRTGGDHRLSNFLPWQAA
                     YAELVFLDTLWPDLDRTGLWQAVETYARRERRFGGLGEAAAQGRIEST"
     gene            complement(5901..6695)
                     /locus_tag="BGV78_RS28330"
     CDS             complement(5901..6695)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-123). E-value: 5.7e-08. Score:
                     24.8. Matches aSDomain:
                     nrpspksdomains_BGV78_RS28330_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640254.1"
                     /locus_tag="BGV78_RS28330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_010640254.1"
                     /transl_table=11
                     /translation="MQISLDGRTALVTGSTQGIGAAIAAGLAEAGARVAVNGRDAVRTE
                     EAVERLRSRVPGGELFSAPGDLATDEGLAEVLDRLPQTDILVNSLGIFGARPALEIDDA
                     EWRRYFEVNVLTAVRLIRAYLPSMKERGWGRVLNIASDSAVVIPAEMIQYGMSKTALLA
                     VSRGFAKEAAGTGVTVNSVIAGPTHTGGVEEFVYDLVGKDLPWDEAQRAFMREYRPQSL
                     IQRLIEPEEIAHLVVYLSSPLASATTGGALRVDGGYVDSILP"
     aSDomain        complement(6327..6671)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BGV78_RS28330_PKS_KR.1"
                     /evalue="5.70E-08"
                     /label="BGV78_RS28330_PKS_KR.1"
                     /locus_tag="BGV78_RS28330"
                     /protein_end="123"
                     /protein_start="8"
                     /score="24.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGSTQGIGAAIAAGLAEAGARVAVNGRDAVRTEEAVERLRS
                     RVPGGELFSAPGDLATDEGLAEVLDRLPQTDILVNSLGIFGARPALEIDDAEWRRYFEV
                     NVLTAVRLIRA"
     CDS_motif       complement(6579..6665)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BGV78_RS28330_0001"
                     /evalue="1.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="BGV78_RS28330"
                     /protein_end="39"
                     /protein_start="10"
                     /score="17.7"
                     /tool="antismash"
                     /translation="LVTGSTQGIGAAIAAGLAEAGARVAVNGR"
     misc_feature    complement(6745..6759)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(6818..7588)
                     /locus_tag="BGV78_RS28335"
     CDS             complement(6818..7588)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409383.1"
                     /locus_tag="BGV78_RS28335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_030764454.1"
                     /transl_table=11
                     /translation="MVSAPGAAAGVLAGGALAVAAWHIGPAATWLPGLRTAYFPGLDGR
                     GAPGRVALTFDDGPDPLSTPHFLRALEALRVQATFFVLGSRLERAPELGRRMVAAGHEV
                     AVHGWEHDRPWLPRPGRDAAELARAAAAVRRITGRRPLWYRPPYGILTGGRWAAARRTG
                     LRPVLWSAWGRDWTASATPDGVVAEAAARLGPGGTLLLHDSDAYAAPDSWRVTLAALPH
                     LVAYCRGLGLEVGRLGDHGHPGSGVPYGFPGRAG"
     gene            complement(7582..8463)
                     /locus_tag="BGV78_RS28340"
     CDS             complement(7582..8463)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468727.1"
                     /locus_tag="BGV78_RS28340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DMT family transporter"
                     /protein_id="WP_018468727.1"
                     /transl_table=11
                     /translation="MTVLTVVLALLAALGNAAASVLQRRGTTQVDGGGAAVARWWSWAT
                     RLLRRRVWLWGAALLAVSGLCQAAALAAGPLAVVQPVMTTELLFTMVIGSAVFRRRPDV
                     RTWWAFVAMAAGLGAFMALLSPTGGGSTVPGSRWLWSGVLLAVLMVVLTLVAWRLPPAP
                     AAAVLGSATAIGFAGTAALVKDALGRLPDGGLGALATTWQAYAAVVVGLGSFLLLQLTL
                     RAGPLVASQPAMTLGDAFLSMLLGRVLFGEDLTLGVRLVPELLALALLIAGTVQLARSP
                     LLTSTDGKERPW"
     gene            complement(8479..9270)
                     /locus_tag="BGV78_RS28345"
     CDS             complement(8479..9270)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (13-177). E-value: 9.8e-17.
                     Score: 53.4. Matches aSDomain:
                     nrpspksdomains_BGV78_RS28345_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409381.1"
                     /locus_tag="BGV78_RS28345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_008409381.1"
                     /sec_met_domain="adh_short (E-value: 3.3e-32, bitscore:
                     103.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRPGPGSVTRRTVLVTGASSGIGAAVAESLHADGRWRLLLSGR
                     DGERLAAVAERTGGEAIRSDLAAEGGCEHLAGEAVARAGRVDALVAGAGIGWAGPFVTM
                     PPEEIDRVLTVNLTSTLRLVRLLLPPMVARGTGRLVLIGSMAGWVGVGDEAVYSASKGA
                     LLTFADSLRRELAGTRVRVSVVSPGAVDTPFFARRGTPYHRRRPRPVSAERVARGVREA
                     LVRGRENVLVPGWLALPARLHGAAPGLFGAVADRADPHRGA"
     aSDomain        complement(8740..9231)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BGV78_RS28345_PKS_KR.1"
                     /evalue="9.80E-17"
                     /label="BGV78_RS28345_PKS_KR.1"
                     /locus_tag="BGV78_RS28345"
                     /protein_end="177"
                     /protein_start="13"
                     /score="53.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGAAVAESLHADGRWRLLLSGRDGERLAAVAERTG
                     GEAIRSDLAAEGGCEHLAGEAVARAGRVDALVAGAGIGWAGPFVTMPPEEIDRVLTVNL
                     TSTLRLVRLLLPPMVARGTGRLVLIGSMAGWVGVGDEAVYSASKGALLTFADSLRRELA
                     G"
     CDS_motif       complement(8821..8853)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BGV78_RS28345_0002"
                     /evalue="2.40E+00"
                     /label="PKSI-ER_m5"
                     /locus_tag="BGV78_RS28345"
                     /protein_end="150"
                     /protein_start="139"
                     /score="1.3"
                     /tool="antismash"
                     /translation="VLIGSMAGWVG"
     CDS_motif       complement(9136..9231)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BGV78_RS28345_0001"
                     /evalue="5.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="BGV78_RS28345"
                     /protein_end="45"
                     /protein_start="13"
                     /score="15.7"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGAAVAESLHADGRWRLLLSGR"
     gene            9466..10536
                     /locus_tag="BGV78_RS28350"
     CDS             9466..10536
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409380.1"
                     /locus_tag="BGV78_RS28350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="galactosyldiacylglycerol synthase"
                     /protein_id="WP_061403752.1"
                     /transl_table=11
                     /translation="MGSLRVLLLGASMGAGHDAVSGELARRLRARGAATELCDVLTLLP
                     PGTGPALRAFYRGTVRHAPALYAAIYALFLSPGDGHRPGSAPLAATARARLLRRVRAFR
                     PDLLVPTFHLAAQITGRLRAEGVLSVPSSVFVTDFAVHRGWLHPGNDLYVCLTAQGAEA
                     ARAATGRPAAVSGPVVAPEFHRVAGPHPHAPEPGPPPVLLSTGAWGVGTRTVRTARLLA
                     AHGCRPVLLCGRDERLRRRAARVPGAVALGWTDDMAGLMGAARLLVDNAAGQTAVQALA
                     AGVPVLAWRPLPGHGRDGARSMAAAGLSTYAHDPDDLLAGVRRLLRPGPVRTCQVERGR
                     AAFVADAAELLTRPPG"
     gene            10620..11552
                     /locus_tag="BGV78_RS28355"
     CDS             10620..11552
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (17-307). E-value: 1e-55. Score:
                     181.0. Matches aSDomain:
                     nrpspksdomains_BGV78_RS28355_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468724.1"
                     /locus_tag="BGV78_RS28355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_018468724.1"
                     /sec_met_domain="ADH_N (E-value: 1.9e-10, bitscore: 32.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-21, bitscore:
                     68.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAIIQESYGGPEVLHETRVPRPEPGPGEILVAVRAAGVNPTDWK
                     HRAQAGFVDRLPLVLGWDVSGVVEAVGYGVTLFAPGEEVFGMLPYPHGSGSHAEYVVGP
                     ARAFTRKPTVIDHVQAGALPLVSLTAYQALIDTAGIGPGQRVLIHAAAGGVGHVAVQIA
                     KAHGAYVIGTASAPKHDLLRELGADEVVDYRTTDVAEAVDGVDMVLDPLGGETRARSVG
                     LLRPGGTLVSLLSGGSAEEAAHAAERGVRTATMLVEADHAGMNAVADLVAAGALRPRVE
                     ATFPLAEAAAAHRLGETGRTTGKIVLEVD"
     aSDomain        10671..11540
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BGV78_RS28355_PKS_ER.1"
                     /evalue="1.00E-55"
                     /label="BGV78_RS28355_PKS_ER.1"
                     /locus_tag="BGV78_RS28355"
                     /protein_end="307"
                     /protein_start="17"
                     /score="181.0"
                     /tool="antismash"
                     /translation="TRVPRPEPGPGEILVAVRAAGVNPTDWKHRAQAGFVDRLPLVLGW
                     DVSGVVEAVGYGVTLFAPGEEVFGMLPYPHGSGSHAEYVVGPARAFTRKPTVIDHVQAG
                     ALPLVSLTAYQALIDTAGIGPGQRVLIHAAAGGVGHVAVQIAKAHGAYVIGTASAPKHD
                     LLRELGADEVVDYRTTDVAEAVDGVDMVLDPLGGETRARSVGLLRPGGTLVSLLSGGSA
                     EEAAHAAERGVRTATMLVEADHAGMNAVADLVAAGALRPRVEATFPLAEAAAAHRLGET
                     GRTTGKIVL"
     CDS_motif       11046..11108
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BGV78_RS28355_0001"
                     /evalue="1.70E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="BGV78_RS28355"
                     /protein_end="163"
                     /protein_start="142"
                     /score="26.8"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHVAVQIA"
     gene            11615..12451
                     /locus_tag="BGV78_RS28360"
     CDS             11615..12451
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894526.1"
                     /locus_tag="BGV78_RS28360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_030305960.1"
                     /transl_table=11
                     /translation="MATDVWRIGGELEVGRLGFGAMHLPTEPGPERKNALAVARRAVEL
                     GVTLIDTAHMYGGGANEELLAEALHPYPDDLLIATKVGMARSAAGEWDHDARPEALRDQ
                     VEQALRRLRRDHIGFLQLHRIDPSVPLADQLGALRELREEGKIGHIGLSEVTVGELDEA
                     RRTTEIAGVQNRYNLLDREHEPVLAACASAGIAFLPWRPVAWGDSGAHAEVASVAAELG
                     ATATQVSLAWLLGHSPVILPIPGTADLAHLEENTAAARLRLPAAHRARLDRLAAPA"
     gene            complement(12464..13111)
                     /locus_tag="BGV78_RS28365"
     CDS             complement(12464..13111)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468722.1"
                     /locus_tag="BGV78_RS28365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_079177535.1"
                     /transl_table=11
                     /translation="MSLKVVVAEDSALMREGLVGVLTRFGHQVCAAVGDADALLAAAGE
                     HRPDLVLTDIRMPPGRGDDGLRAAVALRRDRPDLPVLVLSQYLEQSYAAHLLDLGDQRG
                     IGYLLKDRVAAVTEFADTVVRVAGGGTVLDPEVVRQLLRRRQDPLSGLTPREREVLALM
                     AEGRSNAAIARALHVSVAAVNKHIGSILQRLGLPVNGDAHRRVLAVLAYLRS"
     gene            complement(13102..14307)
                     /locus_tag="BGV78_RS28370"
     CDS             complement(13102..14307)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640245.1"
                     /locus_tag="BGV78_RS28370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_071339412.1"
                     /transl_table=11
                     /translation="MHARTAWQALAHHPLAFLATLWPWRALAYLLSGVGVGALTLVVLV
                     AGLLTGLVLLPLGVGAVVLLAVVLGGGVVARVERWRLRLVDLDPAATDHRAPDAPGVRA
                     WLRTRLRDRLTWRELGFTAVSMTALWWMDLLVLAFALALPVLCVTAPLDDPGAWPWVVI
                     GLALLPAAPYTVTGWAGARAALTRLVLAPRDAELTEVRASRARLVGAFDAERRRIERDL
                     HDGAQQRLVSVNVMLGLARLDAGPGTPLGRRLDLIQGELTTAVGELRELSRGVHPRALT
                     DQGLAAALTNLTARSPLPVTVDIALPAPLPASVASTAYFVVAEALANATKHSGAGRAEV
                     RARLRTDTLVLTVHDDGSGGADPAGRGLTGLADRVAAADGILRLSSPSGGPTLLHVEMP
                     CH"
     misc_feature    complement(14449..14460)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
     misc_feature    15522..15537
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.79"
                     /tool="antismash"
     misc_feature    15522..15537
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.5"
                     /tool="antismash"
ORIGIN
        1 agccataccc ggcgtctctg ggcctctgga ccttacgacg gcccgtccaa cccaccaaca
       61 acgtaggacc gactgagccc cgtccgccgg gccgggcggc gcgcaccccg cgccgcccgg
      121 cccggcggcc tgatcatgtc ggccggttcc gctctcggca cccggcgccc gggacgccac
      181 actgtgcacg cgagtcacgc cggttgcccg ccgcgaggaa aggccgacgc atgcagcccc
      241 ccgccacacc cgtaccgcag gagccggacc aggcccccga ggtggccggc cggcgggagg
      301 ggacgcccca cctgaggggc gatctgcggg ccgccgtccc cgacgcctcc gccgccgtcg
      361 gcgtcaccgc cgccgtcttc gtcttcctct ggtaccgcat ggaggcgggc acctcctcga
      421 cggccgccgt gatgccgttc atggacgacc cgcgcgccta ctggatgtac ctgctcagcc
      481 aggcgttcgg ctggtccgcg ctgctctggg cgtggggcac cgtcatgctc ggcctggtgc
      541 tctccggccc ccggaccgcc cggcagccac cccgccgcac cctggagcgc tggcaccgca
      601 ccaccagcct caccaccacc gcgctgatgt tcgcgcacgc cctgatgttc gcggcggaac
      661 tggtccgcca cgacacccgc cccgcctggc tcacccggct ctggtccgcc ttcgccgact
      721 ccttcgtgcc cggctggtac gactcgggca ccggccagat cgccatcccc atcggccagg
      781 ccgccctcta cctcgccgtc cccctcggcc tgctcttcta cgtacgccac cgcatcggcc
      841 cccgcacctg gcgccgcctg caccgcttcg tcctcgccgt ctacgtgctc agcgtctggc
      901 acaccctgct gtacggcacc aacgtctggt acggcgaatg gccgcgcacc gtgctctggc
      961 tcctccagat ccccgtcgcc ctcctcctcg tggtgcgcct cgcccgcccg gcccgccgcg
     1021 ccgaacggct cggcgccccc ggccgccccg gcgggccggg gctgccggag tggaccgccc
     1081 gcgcgctcgg acgcctcgcg gccgccgcgg tcgtcgccgg catcctcgcc gtggtggtca
     1141 gcggtcacga cggcggccgc acccgtcccg ccgacccgcc ggcgagcacc ccgcacgacc
     1201 acggctccgg ctgagcgacc cgccgggacg gccgcccccg accccgctcg cggtggtggc
     1261 cccgcgcagg tacacctagc cttttcctag agccgcagcg gcgtggaagg caggggtcgg
     1321 gtggccggtg agaccgagtt tcccgaggga gcgcgggccg acggactgcc cgccgcgctc
     1381 tccgaccccg cacgcctcgc ggcggtgcgc ggcaccggcc tgctcgacac cggccccgag
     1441 ccggtcttcg aggacctggc caccctcgcc gcccggatca ccggcgccgg acgcgccttc
     1501 gtcaccctgg tcgacgagga acgctcgtac tggaagtcct gcgtcggcgt ggacgtcacc
     1561 ggcggccggg agaacccggt gcgggagagc ttctgctact tcctcgtcgg cttcggcggg
     1621 gacccgttca cggtcgagga cgccgcgcac gacccgcgca cccgcgacca ccccggcatc
     1681 gggccgatga agatcggcgc ctgggccggc taccccctgc tcagccccga gggcgaggtg
     1741 ctcggcagct tctgcgtcgt cgacgagtcg ccccgcacct ggaccgaggc ggaccgcgcg
     1801 accctcgcca ccctctcccg ctccgcctcc gccgagatcc acctgcgcca gagcctcgcc
     1861 gcctcccagc acgcccaccg cctctccgcc gacctcgccc acaccctcca gcgggggctg
     1921 ctcccgcccg ccctgcgacc cgtccccgga ctcgacgcgg ccgccgccta cgtcccggcc
     1981 tccgccagcg cccaccacga cgtcaccgtc ggcggcgact tctacgacct cttccacgcc
     2041 gccggcccct actacggcgc cttcctcggc gacgtctgcg gcaagggcgt cgaggcggcc
     2101 caggtcacct ccatggcccg ctacacgctg cgcgccgacg ccggcgaggt cctctccccg
     2161 gcacggctgc tgacccgcct caacaccgcc atgctcaccc aggaggcccc gctcttcctg
     2221 accgccgtcc acgccacctt ccgccgcacc cgcgccggcg ccgccggacg cgtctgcctc
     2281 gccggccacc ccaggcccct ggtccgccgc gccgacggcc gggtccgcga gatgggccgc
     2341 cccggcaccc tgctgggcgt catggaggac gtggacctcg ccgacacccg cttccgcctg
     2401 ggccccgggg acctgctgct cctctactcc gacggcgcct acgaggcccg ccccgccccc
     2461 ggcgcacccc ccgaggccac ccgcgagccc ttcggcgagg ccgacctgca cgccaccctg
     2521 gccgccacgc acggcctgga cgccgccgcc accgtcgacc ggatcaccgg cgccctcgcc
     2581 ggccaccacg gcggctgggc cagcgacgac accgccctgc tcgcgctgcg cgtgcccgag
     2641 cgcgactgac cgcccgcgcc cccacgccct tccgcaccac ccgtacggga gcctcgcccg
     2701 ccgtcgttca ccggccatga cgacgaccac acccgtgctg cgcctcagag acgtccacaa
     2761 acgctacggc ccgcgcaccg tcctgaaagg ggccgacctg gacgccgcgc ccggccggct
     2821 gatcggcgtg gtcggggaga acggcgcggg caagagcacc ctgctgcgca tcctcgccgg
     2881 tgagctgcgc gccgaccggg ggacggtgcg cctgcccgcc accgtcggcc actgcccgca
     2941 gaccgtggtc ctgcaccacg ccctcaccgt cgcccagcac ctgcggtact tccaggtcgc
     3001 ctacggcctg ccggagccca cccgcgcctg ggaactcctg gaggaactgc ggttcgccgc
     3061 cgggccccgg gaccggaccg gcaccctcag cggcggcacc cggcagaaac tcaacctcgc
     3121 cgtcgccctc atgcacgacc ccgaactcct cctgctcgac gagccctacc agggcttcga
     3181 ctgggagacc tacctgcggt tctgggagat cgcccgctcc ctctgcgagc ggggccgcac
     3241 cgtcctggtc gtctcccaca tggcgcacga cgccgaccgc ctcgacgccc tgcaccggct
     3301 ggccggcggc cgcctcacac ccgtccacga cgggggccgc gcatgacgcg ccttcggctc
     3361 tgcctcgcga cggccctgcg gtacgccgtc ctcgaacagg tacgcaaccg gctcgccctc
     3421 gcgctcgccg tcttcttcgt ccccgtctgg gtcggcctcg cgtacaccgc catgcccacc
     3481 gcgccggtcc ggttcttcct gcgcgccgcc gaccaggacg tcaccgtcgc cgggaacgtc
     3541 ctcacccagc tctccggcgc cgtccacgcg ctggccctga tcgtcggctt catgatgttc
     3601 ctggccgccc gccgctccgc cgccttcgac caccgcctgg tcaccgccgg ctacccgcgc
     3661 gcctgcctgg tcctcgccaa gtacctggcc ctgctgctcg cctgcctcct cgtcgccggc
     3721 tacgccaccg cctggatctg cgtcttctgg cgccccgagc agcccgtcct gctggccgcc
     3781 gccctcggcg cgggcgcgct cacctacggc ggcgccggca tcatgctcgc cgcgctgctc
     3841 cgcagcgaac tggccgggat gttcctggtc atcatggcca gcttcgtcga cgtcagcctc
     3901 cagaacccga tcgccaacgc cggcgccgac agccccgtcc tgcgctggct gcccacctac
     3961 ggcgccatgc agtccgccgt ggtcgccgcc gacacccgcc acctgccctg ggcccacctc
     4021 ggcctcgccc tcctgtgggc cctgaccacc gccgccgtcg gcacggccgc cttcaccctg
     4081 cacacccgca gccgcctcgg cgccctgcac cgcacctggc gcctgccccc gctgcgccac
     4141 cgcgtctacc ggcgggcggg cgtgaacgac ccggagctgc gcgccggtta cgagacctgc
     4201 cgccgcctgg tgcgccgctc cggccagacc gactacgccg tcacccagct cgtccccgcc
     4261 cccctgcgcc cactgctctg ggcgatgtac gggcacggcc gggtcctgga cgacctctcc
     4321 gacagcggcc gcaccgacgc cgccgaacgc atcgacgcct gggtgcgggc gatggaggag
     4381 gacctcgccc ggggcaccag caccgacccg gtgcggcggg cactgaccca cgccgtcacc
     4441 acctgggacc tgcccaccgg acaactcccc gcctccttcg ccacctaccg ccgggacgcc
     4501 gccgaacgcc ccggcttcac ctcctgggag cagtggcacg cctactggca cgccctcagc
     4561 ttccccgtcg gcgtcacccg cctcgcgacg ctgctgggcg aggccaccgg gacccgcctc
     4621 ggcccgcgcg acgccgaggc gctgcggaga tggaccgacg ccttcaacct cgtcgacgcc
     4681 ctgcgcgacc tgcgccagga cgcccacctg ggccgcgtcg ccctccccct gccggtcctc
     4741 gccgcccacg gcgtgaccct cgccgacctg cgcacagccc gtcggacgcc acaactccac
     4801 gccctggtaa gggagctggc cgtcaccgcg cgcggctggc tggacgacgc cgacggcctc
     4861 gccgaccgcc accccgccct cgccgcctcc tggcgcaccc tcatccgtct ccagcgcctc
     4921 cagctgcggg ccctggaacg aggccgcccg cgctccggag gccgccgggg caccggccgc
     4981 ctccgccgcg ccctggtcct gcacaccggc cggctgcacg ccgcgctgaa ctggcggcgc
     5041 ctcggtccgg tcctcacacc gccgcagggc gcacgcgtcc ccgcgccccc gccgcccctc
     5101 accccggtcg tgccgcgccc gcgtccggcc gaaccgccgc tgccgccacg cccgcacgcc
     5161 ggcggggcga ggccgccggc cggactgggc gaccgggtgc cccggcacgt ggcgatcatc
     5221 atggacggca acggccgctg ggctgccgaa cggggcctgc ccaggccgcg cggccacgcg
     5281 gcgggccagt cggcgctgcg ggacgtggtc tacggcgccc tggaactcgg catcccgcac
     5341 ctgaccctct acgggctctc caccgagaac tggaagcgcc cggcggccga ggtggaggag
     5401 atcctccggc tcctcggcga gggcgcggac gccgaccgcg aggaggtctt cgcccgcgac
     5461 gtacggctgt ggtggtccgg tctgcccgag ggcctgcccg ccgggctcct cgacgcgctg
     5521 gagagcacgg tccggcgcac cgcccaccgc cggggcctga cgctgaccct ctgcgtcaac
     5581 tacggcggcc gggccgagat caccgccgcc gcccggaagc tcgccggtga cgtggccggt
     5641 ggcggcgtcc acccctccgc cgtcacggca ccgctcttcg cccgctacct gcaccggccc
     5701 gcgctgcccg acgtcgacct gctgatccgg accggcggcg accaccgcct ctccaacttc
     5761 cttccctggc aggccgccta cgccgaactg gtcttcctcg acaccctctg gcccgacctc
     5821 gaccgcaccg gcctgtggca ggccgtcgag acgtacgccc gccgcgagcg ccgcttcggc
     5881 gggctcgggg aggcggcggc tcagggcagg atcgagtcca cgtaaccgcc gtccaccctc
     5941 agggcgccgc cggtcgtcgc ggaggccagc ggggagctga ggtagacgac caggtgggcg
     6001 atctcctcgg gctcgatcag ccgctggatg agggactgcg ggcggtactc gcgcatgaag
     6061 gcgcgctgcg cctcgtccca ggggaggtcc ttgccgacca ggtcgtagac gaactcctcc
     6121 acgccgccgg tgtgggtggg gccggcgatc accgagttga cggtgacgcc ggtcccggcg
     6181 gcctccttgg cgaaaccgcg ggagacggcg aggagggcgg tcttcgacat gccgtactgg
     6241 atcatctcgg ccgggatcac caccgccgag tcgctggcga tgttcaggac ccggccccag
     6301 ccgcgctcct tcatactcgg caggtaggcg cggatcagcc ggacggccgt caggacgttc
     6361 acctcgaagt agcggcgcca ctccgcgtcg tcgatctcca gcgcgggacg cgcgccgaag
     6421 atgccgaggc tgttgacgag gatgtcggtc tgcggcagcc ggtccagcac ctcggccagc
     6481 ccctcgtcgg tggccaggtc cccgggcgcg gagaacagtt ccccgcccgg cacccggctc
     6541 cgcagccgct cgaccgcctc ctcggtgcgt acggcgtcac gcccgttgac cgccacccgt
     6601 gcgcccgcct ccgccaggcc ggcggcgatc gccgcaccga tgccctgggt ggaaccggtg
     6661 accagggcgg tcctgccgtc cagagagatc tgcatcctgc tcggaactcc tcgcgtcgtc
     6721 ggtacgccgc atcgcctgcc catgatggcc acccctgata cgccctgtcc tgcgggacgg
     6781 cgcaacggga gaccggctcc gggtcgctcg ggagccctca ccccgcccga cccggaaacc
     6841 cgtacggcac cccgctcccc ggatgcccgt ggtccccgag ccgccccacc tccagcccga
     6901 gcccccggca gtacgcgacc aggtgcggca gggccgccag ggtcacccgc caggagtccg
     6961 gagccgcgta ggcgtccgag tcgtggagca gcagcgtgcc gccgggcccc agccgggcag
     7021 cggcctcggc gacgacgccg tccggggtcg cggaggcggt ccagtcgcgg ccccacgccg
     7081 accagagcac cgggcgcagc ccggtccgac gcgcggcggc ccagcggccg ccggtgagga
     7141 tgccgtacgg cggccggtac cagagcggcc gccgccccgt gatccgccgc accgcggccg
     7201 cggcccgggc cagttccgcc gcgtcccggc ccggccgggg cagccacggg cggtcgtgct
     7261 cccagccgtg caccgccacc tcgtgcccgg ccgccaccat ccgccggccc agctccggag
     7321 cgcgctccag cctgctgccg aggacgaaga aggtggcctg gacacgcaac gcctccagcg
     7381 cccgcaggaa gtgcggggtg ctcagcgggt ccggcccgtc gtcgaaggtc agcgccaccc
     7441 ggccgggcgc cccccgtccg tcgagcccgg gaaagtacgc cgtacggaga ccgggcagcc
     7501 aggtcgccgc cggaccgatg tgccaggcgg cgaccgccag cgcacccccg gccagaaccc
     7561 cggccgccgc gcccggcgcg ctcaccacgg ccgttccttt ccgtcggtcg aggtcagcag
     7621 gggagaacgg gccagctgca cggtgcccgc gatcagcagc gcgagcgcca gcagttccgg
     7681 caccagccgc accccgagcg tcaggtcctc gccgaagagg acccggccca gcagcatgct
     7741 gaggaaggcg tcgcccagcg tcatcgccgg ctgcgaggcc accagcggcc ccgcccgcag
     7801 cgtgagttgc agcagcagga aactccccag ccccacgacg accgccgcgt acgcctgcca
     7861 ggtggtggcc agcgccccga ggcccccgtc cggcagccgt cccagggcgt ccttgaccag
     7921 ggccgcggta ccggcgaagc cgatcgcggt ggcgctgccg aggaccgcgg cggccggtgc
     7981 gggcggcagc cgccaggcca ccagcgtcag caccaccatc agcaccgcca gcagcacccc
     8041 cgaccacagc caccgcgacc ccggcaccgt cgaaccgccg ccggtggggg agagcagcgc
     8101 catgaacgcc ccgagtccgg cggccatcgc gacaaaggcc caccacgtcc tgacgtccgg
     8161 gcggcggcgg aagacggcac tgccgatgac catggtgaaa aggagttcgg tggtcatcac
     8221 cggctgcacc acggcgagcg gcccggccgc cagcgccgcc gcctggcaga gcccggagac
     8281 cgccagcagc gccgcgcccc acagccacac ccggcgccgg agcagccgcg tggcccacga
     8341 ccaccaccgg gcgacggccg ccccgccgcc gtccacctgc gtggtgccgc gccgctggag
     8401 caccgaggcg gccgcgttgc cgagcgccgc gaggagcgcc agcaccaccg tcagcacggt
     8461 caccggcgcg cccccgcctc aggcaccgcg gtgcgggtcg gcacggtcgg ccacggcccc
     8521 gaacagcccc ggcgccgccc cgtgcagccg cgccggaagc gccagccacc ccggcaccag
     8581 gacgttctcc cggccccgca cgagcgcctc ccgcaccccg cgcgccaccc gttcggcgga
     8641 gaccgggcgc ggacggcgcc ggtggtacgg ggtgccgcgc cgggcgaaga acggcgtgtc
     8701 caccgcgccc ggcgacacca ccgagacccg cacccgggtc ccggccagct cccggcgcag
     8761 gctgtccgcg aaggtcagca gggcgccctt ggacgccgag tagaccgcct cgtcgcccac
     8821 cccgacccag ccggccatcg acccgatcag caccagccgg cccgtgccgc gcgccaccat
     8881 cgggggcagc agcagccgga ccagccgcag ggtggaggtg aggttgacgg tcaggacccg
     8941 gtcgatctcc tccggcggca tcgtcacgaa gggacccgcc cagccgatcc ccgccccggc
     9001 caccagcgcg tcgacgcgcc cggcgcgggc cacggcctcg ccggccaggt gctcgcagcc
     9061 gccctcggcc gccaggtcgg agcggatcgc ctcgccgccg gtccgctccg cgaccgccgc
     9121 gagccgctcc ccgtcgcggc cgctgagcag cagccgccac cggccgtcgg cgtgcaggga
     9181 ctcggccacc gcggcgccga tgcccgaaga ggcacccgtg accagcacgg tccgccgggt
     9241 cacggacccg ggtccgggac gccgcgtcat gccgcccact cctcgcccat gccagtcccc
     9301 ttcctcgcgg cacgcctgcc ctcagcttcc gtgctcggcg ggcggaccgc tcgtccaacg
     9361 ccggggcacg ccgccgccgg gtcacccgaa cgggccgatt gcgcccccgc ccggacgcgg
     9421 catgcaagcg gtggacgagt ccaccggccg ggcgagggga ggagcatggg aagcctgcgg
     9481 gtcctgctgc tcggcgcgag catgggcgcc gggcacgacg cggtcagcgg cgaactggcc
     9541 cgccggctcc gcgcccgggg cgccgccacc gaactctgcg acgtcctcac cctcctgccg
     9601 cccggcacgg gtccggccct gcgcgccttc taccggggga cggtgcggca cgcccccgcg
     9661 ctgtacgccg ccatctacgc cctcttcctc tccccgggcg acgggcatcg ccccggcagc
     9721 gcgcccctgg ccgcgacggc ccgtgcccgc ctgctgcgcc gggtccgcgc cttccgcccg
     9781 gacctgctcg tccccacctt ccacctcgcc gcgcagatca ccggcaggct ccgcgccgaa
     9841 ggcgtcctgt ccgtcccctc ctcggtcttc gtcaccgact tcgccgtcca ccgcggctgg
     9901 ctgcaccccg gcaacgacct ctacgtctgc ctcaccgcac agggcgcgga ggccgcccgc
     9961 gccgccaccg gccgcccggc cgccgtttcc gggcccgtcg tcgccccgga gttccaccgg
    10021 gtggccggcc cgcacccgca cgcccccgaa ccgggaccgc cgccggtcct cctctccacc
    10081 ggcgcgtggg gcgtcggcac ccggaccgtg cgcaccgccc ggctcctcgc cgcgcacggc
    10141 tgccggcccg tcctgctctg cggccgggac gagcggctgc gccgccgggc cgcccgcgtc
    10201 cccggcgccg tcgccctcgg ctggacggac gacatggcgg ggctgatggg cgccgcccgc
    10261 ctcctggtcg acaacgccgc cgggcagacc gccgttcagg ccctcgccgc cggtgtgccc
    10321 gttctcgcct ggcggccgct gcccggccac ggccgcgacg gggcgcggag catggccgcc
    10381 gccggactca gcacgtacgc ccacgatccg gacgacctgc tggcgggcgt ccggcggctg
    10441 ctccgccccg ggccggtgcg cacctgccag gtggagcggg gccgggccgc cttcgtcgcg
    10501 gacgccgccg agctgctgac ccggcccccg ggctgaccgg ttcacccgcg caccggcccg
    10561 gcgtggtgcg gaacgcggcc gtccgcgagg ctgggcttat gacgcaggag ccaggcacga
    10621 tgcgcgccat catccaggag agctacggag gccccgaggt cctccacgag acccgggtgc
    10681 cgaggcccga gcccggaccg ggggagatcc tggtcgccgt gcgcgccgcc ggggtcaatc
    10741 ccaccgactg gaagcaccgc gcgcaggcgg gcttcgtcga ccggctcccg ctcgtcctcg
    10801 gctgggacgt ctccggcgtg gtggaggccg tcggctacgg ggtgaccctc ttcgcacccg
    10861 gcgaggaggt cttcggcatg ctgccctacc cgcacggctc cggctcgcac gccgagtacg
    10921 tcgtcgggcc cgcccgcgcc ttcacccgta agcccacggt gatcgaccac gtgcaggcgg
    10981 gcgcgctccc tctggtctcc ctcaccgcct accaggcact gatcgacacc gccgggatcg
    11041 gccccggaca gcgcgtcctg atccacgcgg cggcgggcgg cgtcgggcac gtggccgtac
    11101 agatcgccaa ggcgcacggc gcgtacgtca tcggcacggc cagcgccccc aagcacgacc
    11161 tgctgcgcga actgggcgcc gacgaggtgg tggactaccg caccaccgac gtcgccgagg
    11221 cggtcgacgg cgtcgacatg gtgctcgacc ccctcggcgg cgagacccgc gcccgctcgg
    11281 tcggcctgct gcgccccggc ggcaccctgg tctccctgct ctccggcggt tcggccgagg
    11341 aggcggcaca cgccgccgag cggggcgtgc gtaccgcgac gatgctggtc gaggccgacc
    11401 acgcaggcat gaacgccgtc gccgacctgg tcgccgcggg agccctccgc ccgcgcgtcg
    11461 aggcgacctt cccgctggcc gaggcggccg ccgcccaccg gctcggcgag accggacgga
    11521 ccaccgggaa gatcgtcctg gaggtggact gaggaacgga ccattcctca accgcgctgc
    11581 tagcgtggcc acttcaccgg cgggggagtg gcgtatggcg acggacgtgt ggcggatcgg
    11641 cggggagctg gaggtcggga ggctcgggtt cggggcgatg cacctgccga cggaacccgg
    11701 ccctgaacgg aagaacgcgc tggccgtcgc ccggcgcgcc gtcgaactgg gcgtcaccct
    11761 catcgacacg gcccacatgt acggcggcgg cgccaacgag gagctgctcg ccgaggccct
    11821 gcacccctac cccgacgacc tgctgatcgc gaccaaggtg ggcatggccc ggtcggcggc
    11881 gggggagtgg gaccacgacg cccgccccga ggccctgcgc gaccaggtcg agcaggcgct
    11941 gcggcggctg cgccgcgacc acatcggctt cctgcaactg caccgcatcg acccctcggt
    12001 cccgctcgcc gaccagctcg gcgccctgcg ggagctgcgc gaggagggca agatcggcca
    12061 catcgggctc tccgaggtca ccgtcggcga actcgacgag gcgcggcgga ccaccgagat
    12121 cgcgggcgtg cagaaccggt acaacctgct ggaccgcgag cacgaacccg tcctcgccgc
    12181 ctgcgcgtcg gcgggcatcg ccttcctccc gtggcggccg gtcgcctggg gcgactccgg
    12241 cgcccacgcg gaggtggcct ccgtcgcggc cgaactcggc gccaccgcca cccaggtctc
    12301 cctcgcctgg ctcctcggcc actccccggt gatcctcccg atcccgggca ccgccgacct
    12361 ggcgcacctg gaggagaaca ccgccgccgc gcgcctccgg ctgccggccg cgcaccgggc
    12421 ccgcctcgac cggctggcgg cccccgcctg atctgccggg aggtcagctc cgcagatagg
    12481 ccagcaccgc caggacccgc cggtgggcgt caccgttcac cggcaggccg aggcgttgca
    12541 ggatgctgcc gatgtgcttg ttgacggcgg ccaccgagac gtgcagggcc cgggcgatgg
    12601 ccgcgttgga tcggccctcg gccatcagcg ccagcacctc ccgctcccgg ggcgtgagac
    12661 cgctcagcgg gtcctgccgg cgtcgcagca actgccgtac cacctccggg tccaggaccg
    12721 tgccgccgcc cgccacccgg accacggtgt cggcgaactc ggtgaccgcc gccacccggt
    12781 ccttcagcag gtagccgatg ccgcgctggt cgccgaggtc gagcagatgg gcggcgtagg
    12841 actgctccag gtactggctg aggacgagga ccgggaggtc cgggcggtcg cggcggaggg
    12901 cgacggcggc gcgcagcccg tcgtcgcccc ggccgggcgg catgcggatg tcggtgagga
    12961 cgaggtcggg ccggtgctcg ccggccgccg cgaggagcgc gtccgcgtcc cccaccgccg
    13021 cgcacacctg gtggccgaag cgggtcagca cgcccaccag gccctcccgc atcagcgccg
    13081 agtcctcggc gaccacgacc ttcagtgaca cggcatctcc acgtggagca gggtgggccc
    13141 gccggacggg ctggacagcc gcagtatgcc gtccgccgcc gccacccggt ccgcgagccc
    13201 cgtcagcccc cgcccggcgg ggtccgcgcc cccgctcccg tcgtcgtgga cggtcagcac
    13261 cagcgtgtcg gtacgcagcc gggcccgtac ctcggcgcgg cccgcgccgc tgtgcttggt
    13321 cgcgttggcc agcgcctcgg cgaccacgaa gtacgcggtg ctcgcgacgg acgcgggcag
    13381 cggggccgga agagcgatgt cgacggtgac cgggagcggt gagcgggccg tgaggttggt
    13441 gagggccgcc gcgagaccct ggtcggtcag ggcacgaggg tggacacccc ggctcagctc
    13501 gcgcagctca ccgacggccg tcgtcaactc gccctgtatg agatccagcc ggcggccgag
    13561 cggtgtgccg ggcccggcgt cgagacgggc cagccccagc atcacgttga ccgacaccag
    13621 ccgctgctgc gccccgtcgt gcagatcccg ctcgatccgg cgccgttcgg cgtcgaaggc
    13681 accgaccagc cgggcccgtg aggcacggac ctcggtcagt tcggcgtccc tcggcgcgag
    13741 caccagccgg gtcagcgccg cccgtgcccc ggcccagccg gtgacggtgt acggcgccgc
    13801 cggcagcagc gccaggccga tcaccaccca gggccaggcg cccggatcgt ccagcggcgc
    13861 cgtcacgcac agcaccggga gggccagggc gaaggcgagg acgagcaggt ccatccacca
    13921 cagcgccgtc atggagaccg ccgtgaaccc cagctcccgc caggtcagcc ggtcccgcaa
    13981 ccgggtccgc agccacgccc gcacaccggg cgcgtccggc gcccggtggt ccgtggccgc
    14041 cgggtcgagg tcgaccagcc gcagccgcca ccgctccacc cgcgcgacca caccgccgcc
    14101 gaggaccacg gcgagcagca ccacggcccc caccccgagc ggcagcagca ccagccccgt
    14161 cagcagcccg gccaccagca ccaccaaggt cagcgccccg actcccaccc cggagagcag
    14221 ataggccagc gcacgccacg gccagagcgt ggcgaggaag gcgagagggt gatgggccag
    14281 ggcctgccag gccgttcgcg cgtgcatgga ccgacagtac ggagcccgcg ccgccgggtc
    14341 ggtagtgccc gcaccacctt ttccgtccca gtaccaccac tgcgcccggc cccctgcggc
    14401 cggttggctc tcgggcatga ccacgccccc actccggccc cggcgaaggc gttcgcttct
    14461 ccgggccgcc gcagccgccc tgctttccgc cgcgccgctc ctcgtcccgg tccctgtcca
    14521 ggccgccccg cgtgaggcgc cggtcctcga ccgggccacc gccgaccgct tcgtccgcga
    14581 ccatctggcc cgcacgggag tccccggcgc gacggtcacc gtgacccggg gcgaccgtgt
    14641 cgtcctcgcc gccgggtacg ggcacaccgc ggcgggagag ccgatgaccg cccggacccc
    14701 ggtcccggtc gcctccctct ccaaggcgat gacggcgctg gcggtgacca ccctcgccga
    14761 ggaaggccgc gtcgacctcg acgcgcccgt ccgcgaccag ctccccgagt tcgcccccga
    14821 cgacgcccgc gccgcccgga tcaccccgcg ccaactcctc gaccagacct cggggatggc
    14881 cgactcgacc caccccgatc tcgccctgcc gcagccgtcc accctgaaag ccgccgtcgc
    14941 cgccctccac ggcacgcggc tcgccaccga ccccggcacg gcctggcact accacaacac
    15001 caactacgcc gtcgccgcgc gcctcgtcga gaccgccacc ggcaccctgt acgccgaaca
    15061 cctgcgccgg agcctcttcg cgccgctcgg catgaccggc accgggaccg tcgacaccac
    15121 cgccgacatg cccgacggcg cccgggggta cgtccgcgcc tacggacgga cgatcgaacg
    15181 cgcccatccc cgcctcttca ccgccggtgg cttcggcgtc gtcagtaccg cagacgacct
    15241 ggggaaatgg ctcatcgccc agcacaccga ggggacctcc gccaccggcc gccgcgccgc
    15301 ccccgccgaa gcggtccggc tcacccgcag cccgccgccc ggccagacgt acgcgatggg
    15361 ctggaaccgg cgggaggagc aggggcagcc gttgcggatc gagcacaccg gcagcctctt
    15421 cacccacaac tccatggcca ccctgctgcc cgcctccggc gtggggatcg cggtggtcac
    15481 caacaccggc atggtctccg gggacgacgc cccgctcctc gtcgacggcc tggtcgacct
    15541 cgccgaaggc aggaccccgg cggaccgcgc ccccttcacc gacaccgccg accccgtcct
    15601 cggcctcctc tccctgctcg ccctgggact ggcggtacgc ggcgtcctgc gcgcgggacg
    15661 gtgggcccgc cgcccctggc gcggcctccc gcgcccggcc gcgcgcctcg ccccgtacct
    15721 cctccccggc ctgctcctcc tcggactccc ggacctcttc ggcctcctga tgggccgcgc
    15781 gggaaccctg gcgcagatca cctacgtctg gcccgccctc ttcctctggt ccgcgacaac
    15841 cgccctggca gccacggcgg tactcgcggc ccggggcatc gccctcttcc gggtgcgccg
    15901 gggacgggcg gcgggggacg ggaca
//
