LOCUS       NZ_MNPQ01000018        11368 bp    DNA     linear   CON 11-AUG-2024
DEFINITION  Streptomyces albidoflavus strain OsiLf-2 Scaffold14_1, whole genome
            shotgun sequence.
ACCESSION   NZ_MNPQ01000018
VERSION     NZ_MNPQ01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 210637)
  AUTHORS   Zhu,Y., Zeng,X., Zeng,J. and Liu,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) College of Biology, Hunan University, 1
            Denggao Road, Changsha, Hunan 410082, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. FEBRUARY-2016
            Genome Coverage                   :: 140.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001865795.1-RS_2024_08_11
            Annotation Date                   :: 08/11/2024 02:37:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,098
            CDSs (total)                      :: 6,022
            Genes (coding)                    :: 5,927
            CDSs (with protein)               :: 5,927
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 44 of 95
            Pseudo Genes (incomplete)         :: 58 of 95
            Pseudo Genes (internal stop)      :: 9 of 95
            Pseudo Genes (multiple problems)  :: 15 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:10:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 135017
            Orig. end                         :: 146385
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MNPQ01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6368)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(64..77)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.15"
                     /tool="antismash"
     gene            complement(96..1880)
                     /locus_tag="BGV78_RS22545"
     CDS             complement(96..1880)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470983.1"
                     /locus_tag="BGV78_RS22545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_071338868.1"
                     /transl_table=11
                     /translation="MTPPTPQAPPAGPPTRKALRSLLPVLAAHRAMTARTCAAALVDQA
                     ALVALVTLAAHTVGTAVIDGRPPSTGTAALLLALVAVRALATWREMDLSHDLAYRVLAL
                     LRVRVFDGIARSAPARIAGRRSGDLASTALGDVEALEFFYAHALAQLLATGTVFTASAA
                     LLGTREPWLLALVLPAAALVLALPVLDGRGRAARGARTRAALADLSAETVETVDGLREL
                     LAFGALHRRRARLRAYGRRLARAQRAEQSWEAGAAALRDLLVVAAVIGVVAVAGHSAVE
                     GRLHGAWTPAAMALALGALAPVADAAASLGQAGSLRAAAARVRAAAEAPAGAPAPSTPR
                     PLPEGPLGLHLRGVRFGYGSTPVLDGVDLTVRPGETVALVGASGAGKSTCAHLLARYWD
                     PQEGTVTLVPEDGRPPVALRDLADAELRSAVAVVGQEASLFHGTLAENLLLAAPDAPPD
                     VLDRAVRACGVDVLAAGLPDGLGTAVGERGATLSGGQRARVALARALVAAPRVLVLDET
                     TAHLDHTGDAELAAALAATAPGRATLVIAHRPATVRRADRVAVLEDGRIVEEGTWQELA
                     SAGGALTRLLSREATPTA"
     gene            complement(1877..3622)
                     /locus_tag="BGV78_RS22550"
     CDS             complement(1877..3622)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894136.1"
                     /locus_tag="BGV78_RS22550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_071338869.1"
                     /transl_table=11
                     /translation="MIPPPELRRAARPATLPLAGATALLALVGATHIGQAVLLALVLAR
                     VARGETAGLPALLAAVAAVVLARALLSRAQRLLAVRAGALVRVRLRDDLLAHLGRTGPG
                     ALAGARAGAVRATLVDGVEGVDAYVSRYLPHLMVTCALPPPLLVAVALVEPQAVAALAP
                     ALLLALAGPRLWDRLLARRGREHWDSYEALAADHLEALQGMATLRAAGAVGRTRARLER
                     RSAALHRATVAKMRVSLADTGLTDLAVQGGTVAAVLVACAAATTGSTTATGTYLLLMLA
                     SECFRPVRDLSREWHAGHLGLSAVDGIAALRHTEGGVPDEGTAPAEWATPPEVRFENVH
                     FTHPGRTRPALTGVAFTAPAGRVTALVGRSGAGKSTLLSLLLRQRGPDAGRITVGGLDT
                     AAYRLDALRRGIAVVSQDTYLFRATVADNLRLARPAATPSQLHEAARAAGIHEELTRLP
                     DGYDTVIGERGATLSGGQRQRLALARALLADAPVLLLDEATSAVDERAEARITRELLAA
                     GRGRTCLLVAHRLEAVRHADHIVVLDHGRVDAAGTHPQLLAAGGLYARLVAAGRTVTPM
                     QQEAA"
     gene            complement(3681..4988)
                     /locus_tag="BGV78_RS22555"
     CDS             complement(3681..4988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508299.1"
                     /locus_tag="BGV78_RS22555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitroreductase"
                     /protein_id="WP_071338870.1"
                     /transl_table=11
                     /translation="MTPDATLGHALALARSPRTPARATPPPRRPYPWTGTPLALPATAP
                     DPDGPVDLDHLLRHSLRARPGTGGRLRPAASAGALHPVRAHLLIGPGCTLPPGRYAYDA
                     EVHRVFRRGPAPRGAAPGVIAVLTVTAAHTAAHYGHRAWPLLLLDTGHTAAALALAPQG
                     PGVRVSLDTDAATLAAAAGLPPADRWQRIRPGTETEHPLAAVQVTPRRTQRTAPALDRW
                     AALPLPHRTRTPTRPPARPCGTGRLLELLGAATGTEPAWHPLRRPATVTGRALLERRSA
                     DPAALGHPPDGETVARLLHTAATAWPGGPAWCAAVATPAPALLAPGHHTATPYRLARGD
                     ARPSLAHWAAGQLWLADTGAALLAHGCPSDAPASQIRHDHLAAGFAAGTAHAHAAAEGI
                     NARPVGSWQQADLGAALGDTPGHDWVLHGLALGAAR"
     gene            complement(5001..6368)
                     /locus_tag="BGV78_RS22560"
     CDS             complement(5001..6368)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="BGV78_RS22560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_033238756.1"
                     /sec_met_domain="YcaO (E-value: 3.4e-44, bitscore: 145.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAALPLDALVDPHCGLVRDVAPVPHPEGAPPRYTAMTAHVADAR
                     RFGAWPADRVSLGTTFGDPAGAWTAAVAEAVERYCGNRLPPPGHRDAPRRATAAQLTAE
                     GHQVYGPDDVPAYAPWQYRRPAYPYAPLTPGTPALWARGTENGRDCWAPVALTHLNWRQ
                     GELRALPRTHHLNYAGIATGQGLADAAERALLEVVERDALELWWHLDGPTRGIDPGSVP
                     GLDADLAGSGLEVSIVEMPSEFAPCVAALVHDTRRGVHAAGFACRFDPAEAARKAVLEA
                     VHTWVFTLGAEAADGWVHQAVEAGVLARGLYLDHRADRRYLDDCGEEFAAVRDLGAHVQ
                     AWLDPRLAPLARRFTAPALGTVPVAELAPGSRERLDAALAAGGHRVLTFDLTTEDVAET
                     ALRVARVLVGGLVPNAPAAFGYYGCPRFATAALARGWRTEPPRDPADFTLAPAPHM"
     gene            complement(6365..7891)
                     /locus_tag="BGV78_RS22565"
     CDS             complement(6365..7891)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639446.1"
                     /locus_tag="BGV78_RS22565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_071338871.1"
                     /transl_table=11
                     /translation="MTPATTRLTTPDGTTLATDLHLPATPGPHPAVLIRTPYDRRAHRA
                     ELRGWAERGFAAVAQDVRGRHGSAGEWHPYRDHEAEDGVATLDWIRAQPWSDGRVVAAG
                     ASYAAYCALAAALCPGARGPDAVIAAVPALGLAETAREPTGPERLWARLGWWAAHGDRR
                     DSAPDALDRALARDPSLPAHLPLTRIADRLDRQLPSWPALWADCRRGRLVAHGSAARLP
                     LLAVGGTRDPFAEDTVTLWRGWGGPARLLLGPWGHTLTAGTRPGTPGRVDLGALYARWA
                     RAALDGELGPGRRGVIGLAESGRWHHLTDTPTRREGHEVAGCVWQFGAANGLRLLAGAE
                     FTADPDRPVRSDDLTVPRRAPVDRCLLATPPLPRPLDLAGPAEARLTVVADTPRADWAV
                     RVVALDPAGRADPLAFGIVRRDAPPGIPHPVTVPLGTLGRTLAAGTRLRVEIAGHHFPA
                     HARNPHTGEDPVTATRLAASRRTVRSEGSALHLPVAGRPRPVDPVPETCR"
     gene            complement(7888..8733)
                     /locus_tag="BGV78_RS22570"
     CDS             complement(7888..8733)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470988.1"
                     /locus_tag="BGV78_RS22570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_071338872.1"
                     /transl_table=11
                     /translation="MTSSRLAPGAGIVTVPGGRPAVRTAEGEFLHLDTGTADLAALTRH
                     LVGGEAASDAEVARVAAAFEREGHAVRPDPEEGGPLTGRTVLLLGDARLTGPLARYAAA
                     EGARTRHATLEHVGRLADGEGADASTVVVWCLDEPVPPGLWDAADRLPAHGTAWLRCHR
                     EGAHLWTEPLAAAPGDVTSAHVRLRRLAATSAHRQLAAYWAGHRTPDNGPHPGEAAAAL
                     VAALLTADLLAWAAPGPGSGLPARRRLRRVDLRDLTVTEHPVLPVPPVAPLPGQGSGPA
                     "
     gene            complement(8875..9009)
                     /gene="amiA"
                     /locus_tag="BGV78_RS31705"
     CDS             complement(8875..9009)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="BGV78_RS31705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_008409986.1"
                     /transl_table=11
                     /translation="MEHDKVFAPIADPGQLAHLSATHSNALVENPFDDADEAGAADDK"
     misc_feature    complement(9075..9089)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 13.03"
                     /tool="antismash"
     misc_feature    complement(9076..9089)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 10.54"
                     /tool="antismash"
     misc_feature    9077..9090
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.02"
                     /tool="antismash"
     misc_feature    complement(9077..9092)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            complement(9078..9914)
                     /locus_tag="BGV78_RS22575"
     CDS             complement(9078..9914)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="BGV78_RS22575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_018894131.1"
                     /transl_table=11
                     /translation="MDHREPGAVVAEGLRFGYPGREVLRGVDLRIGAGELVALVGLNGC
                     GKSTFLRLAAGLLRPDAGRVLLDGEEVARLSRRGAARRVALLHQSAPPVPGLTVRQLVR
                     QGRYAARGPLGMLRDGDDAVSARALADAGVADWAGRPVDALSGGERQRVRLAMALAQDT
                     RILLLDEPTTYLDLRHQLEVLQTVVRLRAERGLTVVMVVHDLNHAARFADRIVALRDGR
                     VAADGKPAAIVTPALLAEVLGVEGRVAPDERGGWPVCYPDHPLGAASHLRNENHIH"
     gene            complement(10037..11092)
                     /locus_tag="BGV78_RS22580"
     CDS             complement(10037..11092)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894130.1"
                     /locus_tag="BGV78_RS22580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_071338873.1"
                     /transl_table=11
                     /translation="MSAARTAAPVLRRGRTGTRVKAAVLVLLALAAGVAGLVAGPAVAT
                     ADVAEVFAGGGDPLARHIVLNLRLPRALVALTAGACLALAGLVLQSALRNPLAGPEVTG
                     VTPGAVLGAVTATGLGLAGWQSPTAVVVAACLGGCAGAGLLWLLAGRERGEPEQTAVHG
                     VLVSAVLTGATAVVLLIAPGELGSVVQWLVGSTEGRVWRHWELLWPWALCWGAAAWLLA
                     GPLTLLRCGDEQAAALGLDTGRARAAALACAVALTAGAVSAVGALGFVGLLVPHVALAV
                     FGADLRATLPGAALLGAVVVGGADAGAQLLSRVLAQALDADRLTVPVGALTTCAGAALL
                     LVVARRRADLR"
     misc_feature    11157..11171
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.61"
                     /tool="antismash"
ORIGIN
        1 cagcactcct tcaccggacc gaggagccgg ggtccccgcg aggggccccg gctctttcgc
       61 gtgtgcgtgc gcgtgcacgc acgcttcggt gcgggtcagg cggttggcgt cgcctccctg
      121 gagagcaggc gggtcagcgc gccgccggcg gaggccagct cctgccaggt gccctcctcc
      181 acgatccggc cgtcctccag gacggcgacg cggtcggccc ggcgcacggt cgcgggccgg
      241 tgggcgatga ccagcgtggc gcgcccgggg gccgtggcgg cgagggcggc ggcgagttcc
      301 gcgtccccgg tgtggtccag gtgggccgtg gtctcgtcca ggacgagtac gcggggagcg
      361 gcgaccaggg cccgcgccag ggcgacccgg gcccgctgcc cgccggagag ggtggcaccc
      421 cgctccccca cggccgtacc gagaccgtcg gggagtccgg cggcgaggac atcgacgccg
      481 caggcccgga cggcgcggtc cagcacgtcc ggcggggcgt cgggggcggc cagcagcagg
      541 ttctcggcga gggtgccgtg gaagagggag gcttcctggc cgacgacggc gacggcgctg
      601 cgtagctcgg cgtcggccag gtcccgcagg gcgaccggtg gccgtccgtc ctcggggacg
      661 agggtgacgg tgccttcctg ggggtcccag tagcgggcca gcaggtgcgc gcaggtggat
      721 ttacccgcgc cggaggcgcc gaccagggcg acggtctcgc ccgggcggac ggtgaggtcc
      781 accccgtcca gcacgggtgt ggagccgtac ccgaagcgca cgccacgcag gtggaggccg
      841 aggggtccct cgggcagcgg gcgcggtgtg ctcggcgcgg gggcgccggc gggggcttcg
      901 gcggcggcac ggacgcgggc ggcggcggca cgcaggctgc cggcctgccc gagcgaggcg
      961 gcggcgtcgg cgacaggggc gagggcgccg agcgccaggg ccatcgcggc cggggtccag
     1021 gcgccgtgca ggcggccctc gacggcgctg tggccggcga cggcgacgac gccgatcacg
     1081 gcggccacca ccagcaggtc gcggagggcg gcggcaccgg cctcccagga ctgctcggcc
     1141 cgttgcgcgc gggccagccg ccgcccgtac gcgcgcaggc gggcgcgccg gcggtgcagc
     1201 gcgccgaagg cgaggagttc gcgcagcccg tcgacggtct ccacggtctc ggcggagagg
     1261 tcggcgaggg ccgcgcgggt gcgcgctcct cgtgcggcac ggccccgtcc gtcgaggacg
     1321 ggcagggcga gcacgagcgc ggcggcgggc aggacgaggg cgagcagcca gggttcgcgg
     1381 gtgcccagca gggccgccga ggcggtgaac accgtgccgg tggccaggag ttgggcgagg
     1441 gcgtgggcgt agaagaactc cagcgcctcg acgtcgccca gcgcggtgga ggcgaggtcg
     1501 ccgctgcggc gtccggcgat gcgggcgggg gcgctgcggg cgatcccgtc gaagacgcgg
     1561 acgcgcagga gggcgaggac ccggtaggcg aggtcgtggg agaggtccat ctcgcgccag
     1621 gtggccaggg cgcgcacggc gaccagagca aggagcagcg cggcggtgcc ggttgagggg
     1681 ggccgcccgt cgatcacggc cgttccgacg gtgtgggcgg cgagggtgac gagggcgacg
     1741 agggccgcct ggtcgacgag ggcggccgcg caggtacggg cggtcatggc gcgatgggcg
     1801 gcgagcacgg gcagcagtga gcgaagggct ttgcgcgtgg gcgggccggc cggtggcgcc
     1861 tgcggggtgg gcggggtcat gcggcctcct gctgcatcgg ggtgacggtg cggcccgcgg
     1921 cgaccaggcg ggcgtacagg ccgccggcgg cgaggagttg ggggtgggtc ccggcggcgt
     1981 cgacgcggcc gtggtcgagg acgacgatgt ggtcggcgtg gcggacggct tcgaggcggt
     2041 gggcgacgag caggcaggtg cggccccgtc cggcggccag gagttcccgg gtgatgcggg
     2101 cctcggcgcg ttcgtccacg gcgctggtgg cctcgtcgag gaggaggacc ggggcgtcgg
     2161 cgagcagggc gcgggccagg gcgaggcgct ggcgctggcc gccggagagg gtggcgccgc
     2221 gttcgccgat caccgtgtcg tacccgtcgg gcagccgggt cagctcctcg tggatgccgg
     2281 cggcgcgggc ggcctcgtgg agctgggacg gggtggcggc ggggcgggcg aggcggaggt
     2341 tgtcggcgac ggtggcgcgg aagaggtagg tgtcctggga gaccacggcg atgccccggc
     2401 ggagcgcgtc cagccggtac gcggcggtgt ccaggccgcc gacggtgatc cgcccggcgt
     2461 cggggccgcg ctggcggagc agcaggctca gcagggtgga ctttccggcg ccggagcggc
     2521 cgaccagggc ggtgacgcgt ccggccgggg cggtgaaggc gacgcccgtg agggcggggc
     2581 gggtccggcc cgggtgggtg aagtggacgt tctcgaaacg tacttcggga ggtgtggccc
     2641 attcggcggg ggcggtgccc tcgtcgggga cgccgccctc ggtgtggcgc agcgcggcga
     2701 tgccgtcgac ggccgacagc cccaggtgcc cggcgtgcca ctcgcgggag aggtcgcgga
     2761 cggggcggaa gcactcggag gccagcatca gcagcaggta ggtgccggtc gccgtggtgc
     2821 tccccgtggt ggctgcggcg caggcgacga ggacggcggc gacggtgccg ccctgcacgg
     2881 cgaggtcggt gaggccggtg tcggcgaggg agacccgcat cttggccaca gtggcccggt
     2941 gcagcgcggc cgatcgccgc tccagccggg cccgggtgcg gccgacggcg cctgcggcgc
     3001 gcagggtcgc catcccctgg agggcctcca ggtggtcggc ggcgagcgcc tcgtaggagt
     3061 cccagtgctc gcggccccgg cgggcgagga gccggtccca gaggcggggc ccggcgagcg
     3121 ccagcaggag ggcgggggcg agtgcggcca cggcctgcgg ctcgacgagg gcgacggcga
     3181 ccagcagcgg gggcgggagg gcgcaggtga ccatcaggtg gggcaggtag cgggacacgt
     3241 acgcgtccac gccctcgacg ccgtcgacga gggtggcccg gactgctccc gcccgggctc
     3301 cggcgagcgc gcccgggccg gtgcggccga ggtgggcaag gaggtcgtcg cggaggcgga
     3361 cgcggaccag ggctccggcg cggacggcca gcagcctctg ggcgcggctg agcagcgcgc
     3421 gggccagtac gacggcggcc acggcggcga gcagcgccgg cagcccggcc gtctcgcccc
     3481 gggcgacgcg ggcgaggacg agggcgagca gcaccgcctg cccgatgtgg gtggcgccga
     3541 ccagggcgag cagggcggtg gccccggcca gtggcagggt ggcgggccgg gcggcgcgcc
     3601 gcagttcggg gggcgggatc atcgcgggta cgtctctccg ggcggggtgg ggtggtcggg
     3661 ggcgggccgt gggcggcggc tcatcgggcg gctcccagtg ccaggccgtg caggacccag
     3721 tcgtgtcccg gggtgtcgcc cagggcggcg ccgaggtccg cctgttgcca ggagccgacg
     3781 gggcgggcgt tgattccctc ggcggcggcg tgggcgtggg cggtgcccgc ggcgaagccg
     3841 gcggcgaggt ggtcgtggcg gatctgggag gcgggggcgt ccgaggggca gccgtgggcg
     3901 aggagtgccg ctccggtgtc ggcgagccag agctggccgg cggcccagtg ggcgaggctg
     3961 gggcgggcgt cgccccgggc gaggcggtac ggcgtggcgg tgtggtggcc gggggcgagc
     4021 agggcggggg caggggtggc gacggcggcg caccaggcgg ggccgccggg ccaggcggtg
     4081 gcggcggtgt gcagcagtcg ggccaccgtc tccccgtccg gcgggtggcc cagggcggcg
     4141 gggtcggcgc tgcggcgctc cagcagggcg cgtccggtga cggtggcggg gcggcggagg
     4201 gggtgccagg ccggttcggt cccagtggcg gcgcccagca gttccagcag gcggccggtg
     4261 ccgcagggcc gggccggggg ccgggtgggg gtgcgggtgc ggtgcgggag cggcagggcc
     4321 gcccagcggt cgagggcggg ggcggtgcgc tgggtgcggc ggggcgtcac ctggacggcg
     4381 gcgagggggt gttcggtctc ggtgccgggt cgtatccgct gccagcggtc ggccgggggc
     4441 agcccggcgg cggccgcgag cgtggcggcg tcggtgtcga ggctgacgcg gacgccgggt
     4501 ccctgcgggg cgagggcgag ggcggcggcc gtgtggccgg tgtcgaggag cagcaggggc
     4561 caggcgcggt ggccgtagtg ggcggcggtg tgggcggcgg tgacggtgag gacggcgatc
     4621 acgccggggg ccgctccccg gggggccggg ccgcgccgga acacccggtg gacctcggcg
     4681 tcgtaggcgt accgccccgg gggcagggtg cagccggggc cgatcaggag gtgggcgcgg
     4741 acggggtgga gggcgccggc ggaggcggcg ggccggagtc ggccaccggt gccggggcgg
     4801 gcgcgcaggg agtggcgcag caggtggtcg aggtcgacgg ggccgtcggg gtcgggggcg
     4861 gtggcgggga gggcgagcgg ggtgccggtc caggggtagg ggcggcgcgg gggcggggtg
     4921 gcgcgggccg gggtgcgggg tgatctggcg agggcgaggg cgtggccgag ggtggcgtcg
     4981 ggggtcatgg gggagccggg tcacatgtgc ggggcggggg cgagggtgaa gtcggcgggg
     5041 tcgcgcgggg gttcggtgcg ccagccccgg gcgagggcgg cggtggcgaa gcgggggcag
     5101 ccgtagtagc cgaaggcggc gggggcgttg gggacgaggc cgccgaccag gacgcgggcg
     5161 acgcgcaggg cggtctcggc gacgtcctcg gtggtcaggt cgaaggtgag gacgcggtgg
     5221 ccgcccgcgg cgagggcggc gtcgagccgc tcccggctgc cgggcgccag ctcggcgacg
     5281 gggacggtac cgagggcggg tgcggtgaag cggcgggcga ggggggcgag gcgcgggtcg
     5341 agccatgcct ggacgtgggc gccgaggtcc cgtacggcgg cgaactcctc gccgcagtcg
     5401 tcgaggtagc ggcggtcggc ccggtggtcc aggtagaggc cgcgggccag gacgccggcc
     5461 tcgacggcct ggtgcaccca gccgtcggcg gcttcggctc ccagggtgaa gacccaggtg
     5521 tggacggctt ccaggacggc cttgcgggcg gcttcggccg ggtcgaagcg gcaggcgaaa
     5581 ccggccgcgt ggacgcctcg ccgggtgtcg tggaccaggg cggccacgca gggcgcgaac
     5641 tccgagggca tctcgacgat gctcacctcc aggccggacc cggcgaggtc ggcgtcgagc
     5701 ccggggacgc tgccggggtc gatgccccgg gtgggtccgt ccaggtgcca ccacagttcg
     5761 agggcgtccc gctcgaccac ttcgaggagg gcgcgttcgg cggcgtcggc gagtccctgt
     5821 ccggtggcga tgcccgcgta gttgaggtgg tgggtgcgcg gcagtgcacg cagttctccc
     5881 tggcgccagt tcaggtgggt gagggcgacc ggcgcccagc agtcgcggcc gttctccgtg
     5941 ccgcgcgccc agagggcggg ggtgccgggc gtgagcgggg cgtaggggta ggcgggacgg
     6001 cggtactgcc agggcgcgta ggcgggcacg tcgtccgggc cgtacacctg gtgtccctcg
     6061 gcggtgagct gggcggcggt ggcgcggcgg ggtgcgtcgc ggtggccggg cggcgggagc
     6121 cggttgccgc agtaccgttc gacggcctcg gcgacggcgg cggtccaggc accggccggg
     6181 tcgccgaagg tggtgccgag cgagacccgg tcggcgggcc aggcgccgaa ccggcgggcg
     6241 tcggcgacgt gcgcggtcat ggcggtgtag cggggtggcg cgccctcggg gtgcgggacg
     6301 ggcgcgacgt cgcggacgag tccgcagtgg gggtcgacga gggcgtcgag gggcagggcg
     6361 gcggtcatcg gcaggtctcc ggtacggggt cgacggggcg ggggcggccg gccacgggca
     6421 ggtggagggc gctgccctcg ctgcggacag tgcggcggga ggcggccagg cgggtggcgg
     6481 tgacggggtc ctcgccggtg tgcgggttgc gggcgtgcgc ggggaagtga tggccggcga
     6541 tctcgacgcg cagcctggtc ccggcggcca gggtccgccc gagggtcccg agcggcacgg
     6601 tgacggggtg cgggatgccg ggcggggcgt cgcgccggac gatgccgaag gcgaggggat
     6661 cggcgcgtcc ggccgggtcg agggcgacga cgcggaccgc ccagtcggcg cggggcgtgt
     6721 ccgcgacgac ggtcagccgg gcctcggcgg ggcccgccag gtcgaggggg cggggcagcg
     6781 gcggggtggc gagcaggcag cggtcgacgg gggccctgcg cgggacggtg aggtcgtcgg
     6841 agcgtacggg gcggtccggg tcggcggtga actcggcgcc ggcgagcaga cgcaggccgt
     6901 tggcggcgcc gaactgccac acgcagcccg ccacttcgtg cccctcgcgc cgggtcgggg
     6961 tgtccgtgag gtggtgccag cgtccgctct ccgcgagacc gatgacgccg cgccgcccgg
     7021 gaccgagttc tccgtcgagc gcggcccggg cccagcgggc gtagagggcg ccgaggtcga
     7081 cgcggcccgg ggtgccgggg cgggtccccg ccgtgagggt gtggccccac gggccgagca
     7141 gcagccgggc ggggccgccc caaccacgcc agagggtgac ggtgtcctcg gcgaaggggt
     7201 cgcgggtgcc gccgacggcg agcagcggga gccgggcggc ggagccgtgg gcgaccaggc
     7261 gcccacgccg gcagtccgcc cacagcgcgg gccaggacgg gagttggcgg tcgagccggt
     7321 ccgcgatccg ggtcagcggc aggtgtgcgg gcaggctcgg gtcccgggcg agggcgcggt
     7381 cgagggcgtc gggtgccgag tcgcgccggt cgccgtgggc cgcccaccag ccgagacggg
     7441 cccagaggcg ttcgggtccg gtgggttcgc gggccgtctc ggcgaggccg agggcgggga
     7501 cggcggcgat caccgcgtcc gggcctcggg cgccggggca gagggcggcg gcgagggcgc
     7561 agtacgcggc gtacgaggcc ccggcggcga ccacgcggcc gtcgctccac ggctgggcgc
     7621 gtatccagtc cagcgtggcc acgccgtcct cggcctcgtg gtcgcggtac gggtgccact
     7681 cccccgccga gccgtgccgg ccgcgcacgt cctgcgcgac ggcggcgaac ccgcgctccg
     7741 cccagccgcg cagctcggcc cggtgggccc ggcggtcgta cggggtgcgg atcagcaccg
     7801 cggggtgggg gcccggcgtg gcggggaggt ggaggtcggt ggcgagggtg gtgccgtcgg
     7861 gggtggtgag gcgggtggtc gcgggcgtca tgccgggccg ctcccttgtc cgggcagcgg
     7921 ggccaccggc ggtacgggca gtacggggtg ttcggtgacg gtgaggtcgc gcaggtcgac
     7981 gcggcggagc ctgcggcgcg cggggagccc ggagccgggg cccggcgcgg cccaggcgag
     8041 gaggtcggcg gtgaggaggg cggcgaccag ggcggcggct gcctcgccgg ggtgcgggcc
     8101 gttgtcgggg gtgcggtgtc cggcccagta ggcggcgagc tggcggtggg cggaggtggc
     8161 ggcgagacgg cggaggcgga cgtgggcgga ggtcacgtcg ccgggggcgg cggcgagcgg
     8221 ttcggtccac aggtgggcgc cctcgcggtg gcagcgcagc caggccgtgc cgtgtgcggg
     8281 cagccggtcg gcggcgtccc acagcccggg cggcaccggc tcgtcgaggc accagacgac
     8341 gacggtggac gcgtccgccc cttcaccgtc ggcgagccgg ccgacgtgct cgagggtggc
     8401 gtgccgggtg cgggcgcctt cggcggccgc gtaccgggcg agcgggccgg tgagccgcgc
     8461 gtcgcccagc agcaggacgg tacggccggt gagcgggccg ccctcttcag ggtccggccg
     8521 gaccgcgtgg ccctcgcgct cgaacgccgc cgcgacgcgg gccacttcgg cgtcagaggc
     8581 ggcttcgccg ccgaccaggt ggcgggtgag cgcggcgagg tcggcggtgc cggtgtcgag
     8641 gtgcaggaac tcgccctcgg cggtgcgtac ggcgggccgg ccgccgggga cggtgacgat
     8701 cccggcgccc ggggcgagtc ggctgctggt cacggaaacc tccgtcggat ggagtacgag
     8761 ggatgagcgg cgccggtgcg acggggcgcc gaacgcaacg ggcccgcccg ggggttcgcc
     8821 gggcgggccc gtcacgggtg tcagccggcc gccgtcaccg gcggccgggg ccgactactt
     8881 gtcgtccgcg gcaccggcct cgtcggcgtc gtcgaagggg ttctcgacga gggcgttgga
     8941 gtgggtggcg gagaggtggg ccagctggcc cgggtcggcg atcggggcga acaccttgtc
     9001 gtgctccatg agttgagctc cattcggttc gatgcgtggt ggacgtgaac ggcgtggcgc
     9061 ctgccgcacc acggacatta atgaatatga ttttcattcc gcaagtggct tgcggccccc
     9121 agagggtgat ctgggtaaca gaccggccag ccgccccgct cgtccggcgc cacccggccc
     9181 tcgacaccca gcacttcggc gaggagcgcg ggggtgacga tggcggcggg cttgccgtcg
     9241 gcggccaccc gcccgtcccg gagggcgacg atccggtcgg cgaaccgggc ggcgtggttg
     9301 aggtcgtgca ccaccatcac caccgtcaga ccgcgttccg cgcgcagccg gaccacggtc
     9361 tggagcactt ccagctgatg cctgaggtcc aggtaggtgg tcggttcgtc gaggaggaga
     9421 atccgggtgt cctgggccag cgccatggcg agccgtacgc gctgccgctc cccgccggag
     9481 agcgcgtcga ccggacgccc ggcccagtcg gcgaccccgg cgtcggccag cgcccgcgcg
     9541 ctcaccgcgt cgtccccgtc gcggagcatc ccgagcggcc cccgggccgc gtaccgaccc
     9601 tgccggacca gctggcgcac ggtcagcccc ggtacgggcg gcgccgactg gtggagcagg
     9661 gccacgcggc gggcggcgcc ccggcgggag agccgcgcca cctcctcccc gtccagcagg
     9721 acgcgcccgg cgtccggacg gagcagcccg gcggcgagcc gcaggaaggt gctcttcccg
     9781 cagccgttga ggccgaccag ggcgaccagt tccccggccc cgatccgcag gtcgaccccg
     9841 cgcagcacct cgcgtcccgg atagccgaac cgcagtcctt ccgcgaccac ggcaccgggt
     9901 tcccgatggt ccatcactcc tccttccggc cccgcccgcg ctcgccgggc ggggccgtca
     9961 ctcgtcggta ccggcggcgc ggacgcccgc acggccgtgg ttcggtacgc ctcgggggcg
    10021 tgcggtgtcg gccggctcat cgcaggtcgg cgcggcgccg ggccacgacc agcagcaggg
    10081 cggcgcccgc gcaggtggtc agggcgccca cggggacggt gagccggtcc gcgtccaggg
    10141 cctgggccag gacgcgggag agcagttggg cccccgcgtc ggcgccgccc accacgaccg
    10201 cgccgagcag ggcggcgccg ggcagagtgg cccgcaggtc ggcgccgaac acggcgaggg
    10261 cgacgtgcgg gaccagcagc cccacgaagc cgagcgcgcc caccgccgag accgccccgg
    10321 cggtgagcgc caccgcacag gccagggcgg cggcgcgggc ccgaccggtg tcgaggccca
    10381 gcgcggcggc ctgttcgtcg ccgcaccgca gcagcgtcag cggcccggcc agcagccagg
    10441 cggcggcgcc ccaacacagg gcccacggcc acaggagttc ccagtgccgc cagacgcgtc
    10501 cctcggtgga gccgaccagc cactgcacga cgctgccgag ttcgccgggg gcgatcagca
    10561 gcaccacggc ggtggcaccg gtcagcacgg cggagaccag gacgccgtgg acggcggtct
    10621 gttcgggctc gccccgctcc cgcccggcga gcagccagag cagcccggcc ccggcgcagc
    10681 caccgaggca ggcggccacc accacggcgg tcggcgactg ccagccggcc aggccgagcc
    10741 cggtcgcggt gaccgccccg agcaccgccc ccggggtgac ccccgtgacc tcgggaccgg
    10801 ccagcgggtt gcgcagggcc gactggagga ccagcccggc cagggcgagg caggccccgg
    10861 cggtgagggc gaccagggcg cgcggcagac ggaggttgag cacgatgtgc cgggcgagcg
    10921 ggtccccgcc gcccgcgaag acctcggcga cgtcggccgt ggccacggcg ggcccggcga
    10981 cgagccccgc caccccggcc gcgagggcga ggagcaccag gacggccgcc ttgacccggg
    11041 tgccggtccg gcctctccgg agcaccggcg cggcggtccg cgcggcgctc accgctcggc
    11101 cttccgcagg gcggcccggt cgccgggcgc gggggccggt gaaccgcgtt cgggcgtgcg
    11161 ccatttgagc agggccacac cgaccggcac cccgaacagg gcggtccagg cgccgaccgg
    11221 ggtctcgacg ggggcgagca gcagccgggc cgacaggtcg gcgcagacca cgacgacggc
    11281 gccgcaggcg gccgcgtacc cgagcagccc cgccgcgtcg gcgccgggcc gcagcctccg
    11341 ggccaggtgc ggggcgagga agccgacc
//
