LOCUS       NZ_MNPQ01000009        11329 bp    DNA     linear   CON 11-AUG-2024
DEFINITION  Streptomyces albidoflavus strain OsiLf-2 Scaffold7_1, whole genome
            shotgun sequence.
ACCESSION   NZ_MNPQ01000009
VERSION     NZ_MNPQ01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 405935)
  AUTHORS   Zhu,Y., Zeng,X., Zeng,J. and Liu,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) College of Biology, Hunan University, 1
            Denggao Road, Changsha, Hunan 410082, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. FEBRUARY-2016
            Genome Coverage                   :: 140.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001865795.1-RS_2024_08_11
            Annotation Date                   :: 08/11/2024 02:37:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,098
            CDSs (total)                      :: 6,022
            Genes (coding)                    :: 5,927
            CDSs (with protein)               :: 5,927
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 44 of 95
            Pseudo Genes (incomplete)         :: 58 of 95
            Pseudo Genes (internal stop)      :: 9 of 95
            Pseudo Genes (multiple problems)  :: 15 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:10:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 388878
            Orig. end                         :: 400207
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MNPQ01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11329
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11329
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11329
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6329](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6329)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1025..2497
                     /gene="hemG"
                     /locus_tag="BGV78_RS17305"
     CDS             1025..2497
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008404755.1"
                     /locus_tag="BGV78_RS17305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_033240775.1"
                     /sec_met_domain="DAO (E-value: 1.7e-09, bitscore: 32.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAETEGNPAGAGGASPRVVVVGGGVAGLTAALRLLDAGAGVTLL
                     EASERLGGKLRTGEIGGVRVDLGAESMLARRPEAVGLAREAGLADALQPPATASASLWT
                     RDALRPMPKGHVMGVPADPASLAGVLSEEGVARIAEDRALPRTEVGEDIAVGEYVAARV
                     GREVVDRLVEPLLGGVYAGNAYRISLRAAVPQLFAAAREHTSLTEGVRAIQARTAADPR
                     TDPVFMGIDGGVGRLPLAVADTVRARGGRIRTGTPVTGLARIPSGWRLTTGTPDAPESL
                     EADAVVLAVPAPQAARLLAAELPAASADLAEIEYASMALMTFAFRADEAELPQGSGFLV
                     PPVDGRTVKAATFAGRKWRWIAEQEPGLHVVRTSVGRHREEEILGRDDAGLLALARRDL
                     KAATGVDAEPVDAHVTRWDQGLPQYPVGHLARVARVRDQVAKAPGLALCGAAYDGVGIP
                     ACVASATEAARQVMAARPQGDPASGPSGHAGE"
     gene            2502..3218
                     /gene="hemQ"
                     /locus_tag="BGV78_RS17310"
     CDS             2502..3218
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951588.1"
                     /locus_tag="BGV78_RS17310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_003951588.1"
                     /transl_table=11
                     /translation="MSAAPEKIPNAGKKAKDLNEVIRYTLWSVFKLRDVLPEDRSGYAD
                     EVQDLFDKLAAKDVTVRGTYDVSGLRADADVMIWWHAETADALQEAYNLFRRTRLGRAL
                     EPVWSNMALHRPAEFNKSHIPAFLADETPRDYISVYPFVRSYEWYLLPDEERRAMLADH
                     GKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARRHVREEVPF
                     YTGRRKSVADLVAQLA"
     gene            complement(3232..4878)
                     /locus_tag="BGV78_RS17315"
     CDS             complement(3232..4878)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (105-479). E-value:
                     1.2e-20. Score: 66.1. Matches aSDomain:
                     nrpspksdomains_BGV78_RS17315_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008404759.1"
                     /locus_tag="BGV78_RS17315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_071338395.1"
                     /sec_met_domain="PF00561 (E-value: 3.8e-25, bitscore: 83.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPLILTAAGALLLTPLAAPPQAPAAGAPAPPGGPEARGVALAA
                     ERAARTPVAFGPCPDEEGLPRSLECGTVRVPLDYARPDGEQIDLTVSRAKAAGPKGERQ
                     GALVFNPGGPGSSGMLFPLVGIFPEWKRLASVYDLVGYAPRGVGRSAPLSCRDPREKPD
                     GNWQAPEHPTEQQKAGRKAEAEAYARGCAERGGKRLRHIHSLNNARDLDVVRAGLGERK
                     LTFMGASYGSYFGALYAKLFPSHVRRMVFDSAVDPSPSRVWYRNNMAQSAAFEKRWADF
                     RRWIASHDAAYGMGTDEAQVLAGYRRAREKLAAEPAGGTVGPAQLQAVMLRAQYYEDYW
                     PSHAEALAAYLKGDPQPLVNLATPLEEGRVEAENARAVYTAVECNDAPWPTSWQTWDRD
                     HTRLARTAPFETWENAWMNLPCAYWKEPRQTPMDVRVAPGELPPTLILAGERDAATPYA
                     GALELRRRLPDAALVTERGAGTHGLAGGPNACVNRHVEAYLIDGKLPARSTDCAARPAP
                     EPEAQEAGTRAAGSGARPALPRVAGWSPAAR"
     aSDomain        complement(3442..4563)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BGV78_RS17315_Abhydrolase_1.1"
                     /evalue="1.20E-20"
                     /label="BGV78_RS17315_Abhydrolase_1.1"
                     /locus_tag="BGV78_RS17315"
                     /protein_end="479"
                     /protein_start="105"
                     /score="66.1"
                     /tool="antismash"
                     /translation="ALVFNPGGPGSSGMLFPLVGIFPEWKRLASVYDLVGYAPRGVGRS
                     APLSCRDPREKPDGNWQAPEHPTEQQKAGRKAEAEAYARGCAERGGKRLRHIHSLNNAR
                     DLDVVRAGLGERKLTFMGASYGSYFGALYAKLFPSHVRRMVFDSAVDPSPSRVWYRNNM
                     AQSAAFEKRWADFRRWIASHDAAYGMGTDEAQVLAGYRRAREKLAAEPAGGTVGPAQLQ
                     AVMLRAQYYEDYWPSHAEALAAYLKGDPQPLVNLATPLEEGRVEAENARAVYTAVECND
                     APWPTSWQTWDRDHTRLARTAPFETWENAWMNLPCAYWKEPRQTPMDVRVAPGELPPTL
                     ILAGERDAATPYAGALELRRRLPDAALVTERGAG"
     gene            complement(5001..6329)
                     /locus_tag="BGV78_RS17320"
     CDS             complement(5001..6329)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010641256.1"
                     /locus_tag="BGV78_RS17320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_071338396.1"
                     /sec_met_domain="DUF692 (E-value: 2.9e-95, bitscore: 312.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERLGTGIGWRPAIAEAVEAMAGIEWVEVVAENVCPGHLPDSLLR
                     LRERGVAVVPHGVGLGLGGAERPDPVRLAALAERAEALGSPLVTEHIAFVRAGGERTAS
                     RGLEAGHLLPVPRTREGLAVLCENVRIAQDQLPVPLAVENIAALFSWPGEELTEGQFLY
                     ELADRTGVRLLIDVANLHTNHVNQGEDPAAALDALPLEALAYVHVAGGFERDGVWHDSH
                     AHPVPEPVLAVLAELASRVRPPGVLLERDERFPSAAELEAEVAKIRRTVAVAGRDRVPV
                     GAGARPGSAPASGAGAATGPVADEAARTRLALGQTALLSALVAGTPAPEGFDRGRLRVQ
                     SRMLTAKRGSVVASLAPELEQILGDTYRPRFLRYAAGRPLTGGYRADALAFALHTLREE
                     PPAERAVRRALRDWWIERSGRASLVGRPWARWARVARFALLGR"
     gene            complement(6442..7155)
                     /locus_tag="BGV78_RS17325"
     CDS             complement(6442..7155)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894649.1"
                     /locus_tag="BGV78_RS17325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_008404765.1"
                     /transl_table=11
                     /translation="MTSEPLSDSPFRDERTARDEAPQFVLPLVVRLERAEPPALTDALQ
                     TAARAVLTLLSDPRSEGDGVWAEAVRDWQDARIRKVVRRARGAEWRKAAALPGITVEDG
                     GAEVRVYPPVPLDGWPRELAKLQVSGTELEDPEEPGEPAPGVPVLWLNPDVPMSAGKAM
                     AQAGHGAQLAWWQLSGAERDAWREQGFPLAVRTAGAERWKELVESGLPVVRDAGFTEIA
                     PGSCTVVAEHPALVG"
     gene            complement(7186..8055)
                     /locus_tag="BGV78_RS17330"
     CDS             complement(7186..8055)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951592.1"
                     /locus_tag="BGV78_RS17330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_003951592.1"
                     /transl_table=11
                     /translation="MVRKAKLRTGTALGALMALGAVAGCGQSVPDPHDTAPGPRASHSA
                     SPAAPTAPPTLAPGPGGLAPVFANGPRNDGKTVALTFDADMTADQGERAAGGERFDHPE
                     LIASLRRLKVPATVFMTGRWAEEYPDQARAIGADPLFEIANHSYSHHAFTGDCYGLPRV
                     AESEMRADVERAYTAFRTAGVKKAMPYFRFPGGCYDDAALREVSAAGVTAVQWDVVSGD
                     AFATDADAVAQQVLDGVRPGSVVVMHCTRSAAPTTERALRRIVPALREQGYRFVKVSEL
                     IGAASRKG"
     gene            complement(8221..9585)
                     /locus_tag="BGV78_RS17335"
     CDS             complement(8221..9585)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951595.1"
                     /locus_tag="BGV78_RS17335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PhoX family protein"
                     /protein_id="WP_008404769.1"
                     /transl_table=11
                     /translation="MSATRRQVLARTGAVAGIAFTGSLSELFAGTAAAKGMGKAGYGPL
                     VPDPKGLLDLPKGFRYRVLSREGDRMLSGEGQVPSNHDGMSAFGGRRGQVHLVRNHENR
                     PTAPIRVPPVRGLTYDPEGMGGCTALTLDPGHRVLGERVAIAGTSTNCAGGPTPWGTWL
                     TCEETEDKAGTNGYTKDHGFIFEVDPVDPHRTGAVPLKAMGRFQHEAIAIDPRHGIVYE
                     TEDAFERPFGLFYRFLPEKPRGGLGSLRAGGALQAMRVPGVPDLSAIQETGASFDRVEW
                     VDVPDPLAEETPIRFQDFGPKGITHAQKLEGCYWGGRSVYFVSSFARSSEGSAADHYGQ
                     IWRYDPDRRRLTLVIVFGPDTDVQLPGEEPDNICLAPSGGLMVAEDGEGAQHVYGVTTR
                     GEVYPMARGRQNIGTPEEPAWGEFAGVCFSPDYDTMFVNCYTPGTTFAVTGPWHR"
     gene            complement(9748..10125)
                     /locus_tag="BGV78_RS17340"
     CDS             complement(9748..10125)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010641248.1"
                     /locus_tag="BGV78_RS17340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_010641248.1"
                     /transl_table=11
                     /translation="MTTTQATPRTPVQARFSFLRIALALQTLTVFVQAVSAGLLLSTEY
                     GELLHSAGARVMYGASMLYLLAAVLAWKPGGGSPKAVGYASGFLVLASVQVVSGIAHLS
                     SVHVPLGVLMFGASLVALVRR"
     gene            10229..11125
                     /gene="sigJ"
                     /locus_tag="BGV78_RS17345"
     CDS             10229..11125
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="sigJ"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951597.1"
                     /locus_tag="BGV78_RS17345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor SigJ"
                     /protein_id="WP_071338397.1"
                     /transl_table=11
                     /translation="MGDGVVGERRQLINVAYRLLGSLAEAEDAVQEAYARWYALPPSRR
                     DEIASPGAWLTTVTGRICLDVLGSARARRERYVGAWLPDPLPGRAGRPHGTSGDPADQL
                     VLDESVTMAFLVVLETMTPAERVAFVLHDVFRYPFAEVAGVLDRTPAACKQLAASARRR
                     VRTGAPAPAGGQAETVRRVKEAWEAKDIAALVDLLDPAAVMTADGGGLAGAALRPVEGG
                     PHIARYMTGIAEKAPGLELLERPVNGTPGLVARRAGTVLTVAAFDLAADGRVARIWVIR
                     NPEKLRVWVGDGAPSPR"
ORIGIN
        1 ggccagtccg agggcgagga cgaacggcag cgccgccccg accaccacgg tcagccagcg
       61 cagcgtcgcc acgaacgccg accagccgcc ggagagcgcg tcggtgaagg tcggcccgtc
      121 gtcctcccgc gactccgtct tcgccgtccg ctcggtcagc tggagggtga ccgtcgccat
      181 cgaggtgcgg tccttcagcg aggactgctg ggccagcagc gcctccagct ccatctggcg
      241 gctgctcagc tcgccctcca gcgagacgat gtcgctcagc ttctccgccc ggtccatcag
      301 ctcccggacc cgcgcgacgc tggcgcgctg cgacttcagc cggctctcga cgtccaccac
      361 ctcctcggtg acgtcctccg cgctggtccg ccgggacacc acctcgccgt cctcgccgag
      421 cgagtccagc accgcgtcgt acttctcctg cgggacgcgg accaccacgg tcgaccgctc
      481 gtggtcctgg gagtcgcgcc gggtcgactc gttgccgacg tagccgcccg cgccctccac
      541 caccgagcgg gccgaggcca gcgcggcggg cacgtcctcc acccgcaggt gcagctcggc
      601 cgtccggacc aggtggacgc ccttcagctg ggggcgcgcc ttcccgtccg acgcctcgtc
      661 cgccgactcc cgcttcgcgc tgtcggcctg accgccgccc gcgccgtcgg cggccgacgg
      721 cgcgaccgcg cggtcccccg ccgacgacgc gccggagtcc ggcccggccg agcaccccgc
      781 cagccccagt accgccaccg ccagcaccac ggccgcccgc cgccccgcga tccggccgcc
      841 gctcgatccc cgcatccggc tcatccgccg ccccccttgt ccttccgcgc ccacccctcg
      901 ggggcgcctg tgccgctacg acggagcagc gcaccggtgg gtttcgcctc ccgggtcgcg
      961 aaccggtaac ggaagcgccc gccccggcgc ccgcccgccg cgtccggttt gagacagtgg
     1021 ctccatgcgc gcggaaacag agggaaaccc ggcgggagcg ggtggcgcga gcccccgtgt
     1081 ggtggtcgtc ggaggcggcg tcgcggggct cacggccgcg ctgcgcctgc tcgacgccgg
     1141 ggccggcgtc accctcctgg aagcttccga gcggctcggc ggcaagctcc gcaccggcga
     1201 gatcggcggc gtccgcgtcg acctgggcgc cgagtcgatg ctggcccgcc gccccgaggc
     1261 ggtcggcctc gcccgtgagg cgggactggc cgacgccctc cagcccccgg ccaccgccag
     1321 cgcctccctg tggacccgcg acgccctgcg ccccatgccc aagggccacg tcatgggcgt
     1381 ccccgccgac ccggccagcc tcgccggggt cctctcggag gagggcgtcg cgcggatcgc
     1441 cgaggatcgc gccctgcccc gcaccgaggt cggcgaggac atcgccgtcg gcgagtacgt
     1501 cgccgcccgg gtcggccgcg aggtcgtcga ccggctcgtc gaacccctcc tcggcggcgt
     1561 ctacgccggc aatgcctacc gcatctcgct gcgcgccgcc gtcccccagc tcttcgccgc
     1621 cgcccgcgag cacacctccc tgaccgaggg ggtccgcgcg atccaggccc gcaccgccgc
     1681 cgacccgcgc accgaccccg tcttcatggg catcgacggc ggggtcggcc gcctcccgct
     1741 cgccgtcgcc gacaccgtcc gcgcccgcgg cggccgcatc cgcaccggta cgcccgtcac
     1801 cggcctcgcc cgcattccca gcggctggcg gctgaccacc ggcacccccg acgcgcccga
     1861 gtccctggag gccgacgccg tcgtcctcgc cgtccccgcg ccccaggcgg cccggctgct
     1921 cgccgccgaa ctcccggccg cctccgccga cctcgccgag atcgagtacg cctcgatggc
     1981 cctgatgacc ttcgccttcc gcgcggacga ggccgagctg ccgcagggca gcggcttcct
     2041 cgtgccgccg gtcgacggac gtaccgtcaa ggccgccacc ttcgcaggac gcaagtggcg
     2101 gtggatcgcc gagcaggagc cggggctgca cgtcgtccgc acctcggtcg ggcgccatcg
     2161 cgaggaggag atcctcggcc gcgacgacgc cggcctcctc gccctcgccc gacgcgacct
     2221 caaggccgcc accggcgtcg acgccgagcc cgtcgacgcc cacgtgaccc gctgggatca
     2281 ggggctgccc cagtacccgg tcggccacct cgcccgcgtc gcccgcgtcc gcgaccaggt
     2341 cgccaaggcc cccggcctcg ccctgtgcgg cgccgcctac gacggtgtcg gcatccccgc
     2401 ctgcgtcgcc tccgccaccg aggcggcccg ccaggtcatg gcggcccgcc cacagggcga
     2461 cccggcgtcg ggcccgtccg ggcacgcggg agaatgaccc catgagtgct gctcccgaga
     2521 agatccccaa cgcgggcaag aaggccaagg acctcaacga ggtcatccgc tacaccctgt
     2581 ggtccgtctt caagctccgc gacgtgctcc ccgaggaccg gtccggctac gccgacgagg
     2641 tccaggacct gttcgacaag ctcgccgcca aggacgtcac cgtccgcggc acctacgacg
     2701 tctccggtct gcgcgccgac gccgacgtga tgatctggtg gcacgccgag accgccgacg
     2761 ccctccagga ggcgtacaac ctcttccgcc gcacccgcct cgggcgcgcg ctggagccgg
     2821 tctggtcgaa catggcgctg caccgccccg ccgagttcaa caagtcgcac atcccggcgt
     2881 tcctcgccga cgagaccccc cgcgactaca tcagcgtcta cccgttcgtc cgctcctacg
     2941 agtggtacct cctccccgac gaggagcgcc gggcgatgct cgccgaccac ggcaagatgg
     3001 cccgtggcta cccggacgtc cgcgccaaca cggtcgcctc gttctccctc ggcgactacg
     3061 agtggatcct cgccttcgag gccgacgagc tgtaccgcat cgtcgacctc atgcgccacc
     3121 tgcgcgcctc cgaggcccgc cgccacgtcc gcgaggaggt gcccttctac accgggcgcc
     3181 gcaagtccgt cgccgacctg gtcgcccagc tcgcctgagc cccgctccgc ctcaccgggc
     3241 cgccggggac cacccggcga cccgggggag ggccggccgc gccccgctcc cggcggcccg
     3301 cgtcccggcc tcctgcgcct ccggctcggg ggccggccgg gccgcgcagt cggtggagcg
     3361 cgcggggagc ttcccgtcga tcaggtaagc ctccacgtgc cggttgacgc aggcgttcgg
     3421 cccgcccgcc agcccgtgcg tgcccgcgcc ccgctcggtc accagcgcgg cgtccggcag
     3481 ccgccgccgc agctccagcg cgcccgcgta cggggtcgcc gcgtcccgtt ccccggcgag
     3541 gatcagcgtc ggcggcagct caccgggggc cacccgcacg tccatcggcg tctgccgggg
     3601 ctccttccag tacgcgcacg gcaggttcat ccaggcgttc tcccaggtct cgaacggcgc
     3661 cgtgcgggcg agccgggtgt ggtcgcggtc ccaggtctgc cagctggtgg gccacggcgc
     3721 gtcgttgcac tccaccgccg tgtagacggc ccgcgcgttc tccgcctcca cccggccctc
     3781 ctccagcggc gtcgccagat tgaccagcgg ctgcggatca cccttcaggt acgccgcgag
     3841 cgcctccgcg tgcgagggcc agtagtcctc gtagtactgg gcccgcaaca tcaccgcctg
     3901 gagctgcgcc gggccgaccg tgcccccggc gggctcggcc gccagcttct cgcgcgcccg
     3961 ccggtacccc gccagcacct gggcctcgtc ggtgcccatc ccgtacgccg cgtcgtgcga
     4021 ggcgatccac cgccggaagt ccgcccaccg cttctcgaac gccgccgact gcgccatgtt
     4081 gttccggtac cagacacgcg agggagaggg gtcgaccgcc gagtcgaaga ccatcctgcg
     4141 cacgtgcgag gggaagagct tcgcgtacag cgccccgaag tacgagccgt acgacgcgcc
     4201 catgaacgtc agcttccgct caccgaggcc ggcccgcacc acgtccaggt cgcgggcgtt
     4261 gttcagcgag tggatgtgcc gcagccgctt cccgccgcgc tcggcgcacc cccgcgcgta
     4321 cgcttcggcc tcggccttcc gcccggcctt ctgctgctcg gtcgggtgct cgggggcctg
     4381 ccagttcccg tccggcttct cgcgcgggtc ccggcaggag agcggcgccg accggccgac
     4441 cccgcgcggc gcgtacccga ccaggtcgta gaccgaggcc agccgcttcc actcggggaa
     4501 gatccccacc agcgggaaga gcatcccgga ggagccggga ccgcccgggt tgaagaccag
     4561 cgcgccctgc cgctcgccct tcgggcccgc cgctttggcc cggctcaccg tcaggtcgat
     4621 ctgctcgccg tccggccgcg cgtagtccag cgggacccgt accgtgccgc actccagcga
     4681 ccggggcagc ccctcctcgt ccgggcacgg cccgaaggcg accggggtcc gcgccgcccg
     4741 ctcggccgcc agcgccaccc cgcgcgcctc ggggccgccg ggcggagccg gagccccggc
     4801 cgcgggcgcc tgcgggggag ccgcgagcgg cgtgaggagc agcgctccgg cggcggtgag
     4861 gatgagcggc gcgcgcatcg cgtccctttc gtccggccga tgacagccct agggatgatt
     4921 cgcaggccgg tcggcagggg caagcaccgg ggcgcgtgtt ggacggaccc gctcggatcg
     4981 gcccaacacg gccgccgggt tcagcgcccc agcagggcga agcgcgccac cctggcccac
     5041 cgggcccagg gcctgcccac cagggaggcg cgccccgagc gctcgatcca ccagtcgcgc
     5101 agggcgcgcc ggaccgcccg ctcggccggc ggctcctccc gcaaggtgtg cagcgcgaag
     5161 gcgagcgcgt ccgcgcggta cccgccggtc agcggccggc ccgccgcgta ccgcaggaag
     5221 cgcggccggt acgtgtcgcc gaggatctgc tccagctccg gggcgaggga ggccaccacg
     5281 gagccccgct tggcggtcag catccggctc tgcacccgca gccgcccccg gtcgaaccct
     5341 tccggcgccg gcgtccccgc caccagagcc gacagcagcg ccgtctgccc gagggccagc
     5401 cgcgtccgcg ccgcctcgtc cgccaccgga ccggtcgccg ccccggcccc cgacgccggg
     5461 gcggacccgg gccgggcccc cgcccccacc gggacccggt cccggccggc caccgccacc
     5521 gtccgccgga tcttcgcgac ctccgcctcc agctcggccg ccgacgggaa ccgctcgtcc
     5581 cgctccagca gcaccccggg cggccgcacc cgcgaggcca gctcggccag gaccgccagc
     5641 accggttccg gcaccgggtg ggcgtggctg tcgtgccaca ccccgtcccg ctcgaacccg
     5701 cccgccacat ggacgtacgc cagcgcctcc agcggcagcg cgtcgagagc ggcggcgggg
     5761 tcctcgccct ggttgacgtg gttggtgtgc aggttggcga cgtcgatcag caggcgcacc
     5821 ccggtccggt cggccagctc gtagaggaac tgtccctccg tcagctcctc gcccggccag
     5881 gagaagagcg ccgcgatgtt ctccacggcg agcggcacgg gcagctggtc ctgggcgatc
     5941 cgcacgttct cgcagagcac cgcgagccct tcccgggtcc gggggaccgg cagcaggtgc
     6001 ccggcctcca gcccgcgcga cgcggtccgc tccccgcccg cccggacgaa cgcgatgtgc
     6061 tcggtgacga gcggcgagcc cagcgcctcc gcccgctcgg ccagcgccgc cagccgcacc
     6121 ggatcgggcc gctccgcgcc gcccagcccc agccccaccc cgtgcggcac cacggcgacc
     6181 ccacgttccc gcagccgcaa cagggagtcg gggaggtgac cgggacagac gttctccgcc
     6241 accacctcca cccactcgat ccccgccatc gcctcgacgg cctccgcgat cgcgggccgc
     6301 cagccgatcc ccgttcccag ccgttccata ccgccagccc ctccaggaac cccccggtcc
     6361 ctgcggccac ccctgcccgt tgccgtccgc cccggaaccg tcacccgccc tcttcagagc
     6421 aggatttgag cttcgccgcc ctcaccccac caatgcggga tgctccgcca ccaccgtgca
     6481 cgacccgggc gcgatctccg tgaacccggc gtcccgcacc accggcagcc cgctctccac
     6541 cagctccttc cagcgctccg cgccggcggt ccgcaccgcc agcgggaaac cctgctcgcg
     6601 ccaggcgtcc cgttccgccc ccgacagctg ccaccaggcc agctgcgccc cgtggcccgc
     6661 ctgcgccatc gccttccccg ccgacatggg cacgtccggg ttgagccaga gcaccgggac
     6721 accgggcgcg ggctcgcccg gctcctcggg gtcctccagc tcggtgccgg agacctggag
     6781 cttggccagc tccctgggcc agccgtccag cggcaccggc gggtagacgc gcacctcggc
     6841 gccgccgtcc tcgaccgtga tccccggcag ggccgcggcc ttgcgccact ccgcgccccg
     6901 ggcccgccgc accaccttgc ggatccgcgc gtcctgccag tcccgcaccg cctccgccca
     6961 cacgccgtcc ccctcggagc ggggatcact gagcagcgtc aggacggccc gggcggccgt
     7021 ctggagcgcg tcggtgaggg cgggcggctc ggcgcgctcc agccggacga cgagcggcag
     7081 cacgaactgc ggtgcctcgt cgcgggcggt gcgctcgtca cggaagggac tgtcggagag
     7141 gggttcgctg gtcacggagc cagtctgcca aaccgcgggc gaccctcacc ccttccgcga
     7201 ggccgccccg atcagctcgg acaccttcac gaagcggtac ccctgctcgc gcagggcggg
     7261 cacgatccgg cgcagcgcgc gctcggtggt gggggcggca ctgcgggtgc agtgcatgac
     7321 cacgaccgag ccggggcgga ccccgtccag cacctgctgc gccaccgcgt ccgcgtcggt
     7381 ggcgaaggcg tccccgctca ccacgtccca ctgcacggcc gtcaccccgg ccgcggagac
     7441 ctcccgcagc gccgcgtcgt cgtaacaccc gccggggaag cggaagtacg gcatggcctt
     7501 cttcaccccg gccgtgcgga acgcggtgta cgcccgttcc acgtcggccc gcatctcgct
     7561 ctcggcgacg cgcggcaggc cgtagcagtc accggtgaag gcgtggtggc tgtaggagtg
     7621 gttggcgatc tcgaagagcg ggtcggcgcc gatggcccgc gcctggtccg ggtactcctc
     7681 ggcccaccgc ccggtcatga agacggtggc gggcaccttc aggcggcgca gcgaggcgat
     7741 cagctccggg tggtcgaagc gttcgccgcc ggccgcgcgc tcgccctggt cggccgtcat
     7801 gtcggcgtcg aaggtgagcg cgacggtctt gccgtcgttc cggggcccgt tggcgaagac
     7861 cggggcgagc ccgccggggc cgggcgccag cgtgggcggc gccgtcgggg cggcggggga
     7921 ggcggagtgc gaggcccgtg gccccggcgc cgtgtcatgg gggtccggaa cggactgacc
     7981 gcacccggcc accgcgccca acgccatcag ggcgcccagc gccgtaccgg tccggagctt
     8041 cgccttgcgc accatgctga tcacgccgtg accctaggat gcgaaaagct gaatatcggg
     8101 caaaacgccg ccggggcgcg cggcctcacc cgtctcgccc cgccaccctc cgccgtccgg
     8161 gcgcccggcc gggcccacga ggcgggggtg gggcaggaac ccgccccacc cccgctcacg
     8221 tcacctgtgc cagggccccg tgaccgcgaa ggtcgtcccg ggcgtgtagc agttgacgaa
     8281 catcgtgtcg tagtccgggg agaagcagac gcccgcgaac tcaccccacg ccggctcctc
     8341 gggcgtgccg atgttctggc ggccccgtgc catcgggtag acctcgccgc gcgtggtcac
     8401 gccgtagacg tgctgggcgc cctcgccgtc ctcggcgacc atgaggccgc cgctcggggc
     8461 gaggcagatg ttgtccggct cctcgcccgg gagctgcacg tcggtgtcgg ggccgaagac
     8521 gatgaccagg gtgaggcgcc gccggtccgg gtcgtagcgc cagatctgcc cgtagtggtc
     8581 ggcggccgag ccctcgctgc tccgggcgaa gctggagacg aagtagaccg agcggccgcc
     8641 ccagtagcag ccctccagct tctgggcgtg ggtgatgccc ttcgggccga agtcctggaa
     8701 gcggatcggc gtctcctcgg cgagcgggtc gggcacgtcc acccactcca cccggtcgaa
     8761 cgaggcgccc gtctcctgga tcgccgagag gtcgggcacc ccgggcaccc gcatcgcctg
     8821 gagcgcgccc ccggcccgca gtgagccgag gccgccgcgc ggcttctcgg gcaggaagcg
     8881 gtagaagagc ccgaacggcc gctcgaaggc gtcctcggtc tcgtagacga tcccgtggcg
     8941 cgggtcgatc gcgatggcct cgtgctggaa gcggcccatc gccttcagcg gcaccgcgcc
     9001 ggtccggtgc gggtcgaccg ggtcgacctc gaagatgaag ccgtgatcct tggtgtagcc
     9061 gttggtcccg gccttgtcct cggtctcctc gcaggtcagc caggtgcccc agggggtcgg
     9121 cccgccggcg cagttggtcg aggtcccggc gatggcgacc cgctcgccga gaacccggtg
     9181 cccggggtcg agggtgagcg ccgtacagcc gcccatcccc tccgggtcgt acgtcagtcc
     9241 gcgtacgggc gggacgcgga tcggggcggt gggccggttc tcgtggttgc ggacgaggtg
     9301 gacctggccc cggcgcccgc cgaaggcgga catcccgtcg tggttgctcg gcacctggcc
     9361 ctcgccggag agcatccggt cgccctcccg ggacagcacc cggtagcgga aacctttcgg
     9421 caggtccagc agacccttcg ggtcgggcac cagcggaccg tacccggcct tccccatccc
     9481 cttcgcggcg gccgtgcccg cgaagagttc ggagagactg ccggtgaagg cgataccggc
     9541 gacggcaccg gtgcgggcga ggacttgacg gcgtgtcgcg gacatgggca actccctgct
     9601 gcggctctgc ggacaggaat gtgacccgca cgtgtgtacc acgcacccag ccccaccgga
     9661 accaggcgtg gccctggaca cggccgtcac agcccgcctg gcctgctggg aacgcccctg
     9721 acgccgggta cggccgacgg cccggcctca ccgccggacc agcgccacca gactcgcccc
     9781 gaacatcagc accccaagcg gcacatggac cgacgacagg tgcgcgatcc ccgacaccac
     9841 ctgcacggag gccagtacga ggaagcccga cgcgtacccg accgccttcg gcgagccgcc
     9901 gcccggcttc caggcgagca ccgcggcgag caggtacagc atcgacgccc cgtacatcac
     9961 ccgcgccccg gcgctgtgca ggagttcgcc gtactccgtg ctgagcagca gccccgccga
    10021 gaccgcctgg acgaagaccg tcagggtctg gagggcgagc gcgatccgca ggaacgagaa
    10081 gcgggcctga acgggcgtgc ggggtgtcgc ctgggtcgtc gtcatgccgg gtcccccttt
    10141 tccgcgcccg agggcagcgg ccgatgtcga ataaggtctc accagcccga cgacacgggc
    10201 ctcggaaagg taaggcgagg gggcgcgggt gggtgacggg gtcgtcggcg agcggcgtca
    10261 actcatcaat gtggcctacc ggttgctggg ctcgctggcc gaggccgagg acgccgtcca
    10321 ggaggcgtac gcccgctggt acgcgctgcc gccctcgcgc cgggacgaga tcgcctcgcc
    10381 cggggcctgg ctcaccacgg tgaccggccg gatctgcctg gacgtgctgg gctcggcgcg
    10441 ggcacggcgg gaacgttacg tcggggcgtg gctgcccgat ccgctgcccg gccgggccgg
    10501 gcggccgcac ggcacgagcg gcgaccccgc cgaccagctg gtcctggacg agtccgtcac
    10561 catggccttc ctcgtcgtcc tggagacgat gacccccgcc gagcgcgtgg ccttcgtcct
    10621 ccacgacgtc ttccgctacc ccttcgccga ggtcgccggt gtcctcgacc ggacccccgc
    10681 cgcctgcaag cagctcgccg cctccgcccg gcgccgggta cggaccggcg cccccgcacc
    10741 ggccggcgga caggccgaga ccgtgcggcg cgtcaaggag gcgtgggagg ccaaggacat
    10801 cgcggccctc gtcgacctcc tcgaccccgc cgccgtgatg accgccgacg gcggcggcct
    10861 ggccggcgcc gccctgcgcc ccgtcgaggg cggcccccac atcgcgcggt acatgaccgg
    10921 catcgcggag aaggcccctg gcctcgaact cctggaacgc ccggtcaacg gcacccccgg
    10981 cctggtcgcc cgccgcgccg gcaccgtcct gaccgtggcc gccttcgacc tcgccgccga
    11041 cggacgcgtc gcccgcatct gggtgatccg taatccggag aaactgcggg tctgggtggg
    11101 ggacggcgcc ccgtcgccac gttgaccgcg gcgatcccgg ggtagcttcc ccggcatgga
    11161 cttccgaacg accgtcgagc gcgctcagcg ccttcagcag ctgcacgccg accatcagcc
    11221 gctcgtgctg ccgaccgtct gggacgtctg gtccgcccgg acggcggccg acgccggatt
    11281 ccccgcgctg accgtcggca gccaccccct cgccgactcc cggggcgcc
//
