LOCUS       NZ_MNPQ01000007        10216 bp    DNA     linear   CON 11-AUG-2024
DEFINITION  Streptomyces albidoflavus strain OsiLf-2 Scaffold5_1, whole genome
            shotgun sequence.
ACCESSION   NZ_MNPQ01000007
VERSION     NZ_MNPQ01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
REFERENCE   1  (bases 1 to 446686)
  AUTHORS   Zhu,Y., Zeng,X., Zeng,J. and Liu,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) College of Biology, Hunan University, 1
            Denggao Road, Changsha, Hunan 410082, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. FEBRUARY-2016
            Genome Coverage                   :: 140.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001865795.1-RS_2024_08_11
            Annotation Date                   :: 08/11/2024 02:37:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,098
            CDSs (total)                      :: 6,022
            Genes (coding)                    :: 5,927
            CDSs (with protein)               :: 5,927
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 44 of 95
            Pseudo Genes (incomplete)         :: 58 of 95
            Pseudo Genes (internal stop)      :: 9 of 95
            Pseudo Genes (multiple problems)  :: 15 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:10:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 176613
            Orig. end                         :: 186829
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MNPQ01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(558..567)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            681..1580
                     /locus_tag="BGV78_RS12450"
     CDS             681..1580
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008412452.1"
                     /locus_tag="BGV78_RS12450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_071338070.1"
                     /transl_table=11
                     /translation="MRTVLRRSRSVPSRRPRGRVAVAAALAAAALFTAAPPALADTSPS
                     PSVSQDEEAEAGPTEAGTAFRTAARLAQGQRGTASASTGDYLYWVFPADTGQRPTVRAT
                     VSLPAEQARQSASTWRIDVYDGLRRRQPCTYGLQERRAAEDAAEVRLTCTLRTVRAYSE
                     PWANDPLPGAYYVRLTVSRLAADDLGRPFQAEVAVDSRETGGSTAVGGKLSEPLTPGIS
                     AVSAEEQAEEETAEEDGAEQAPRPAALAEPEDGWSSGWWTDRWLWTAGGAVLAALAGVF
                     GYTLTRGNGRPGRVPPGV"
     gene            1771..3588
                     /locus_tag="BGV78_RS12455"
     CDS             1771..3588
                     /NRPS_PKS="Domain: AMP-binding (23-474). E-value: 2.5e-88.
                     Score: 288.3. Matches aSDomain:
                     nrpspksdomains_BGV78_RS12455_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008412454.1"
                     /locus_tag="BGV78_RS12455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_071338071.1"
                     /sec_met_domain="AMP-binding (E-value: 3.2e-84, bitscore:
                     277.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREVSVERLVAPPVSGGLADSVFHTAATYPTRPQLALEPTDHGSP
                     WRTVTAARLRDEVLALARGLLAEGVRPGDRVVLMSRTRPEWTLLAYALWTLGAEVVPVY
                     PTSSIEQVRWVLADASVRAAVVEHSGQAMTIAAACADPGALLGLWQLDLDCTAELAERG
                     AEVPEDEVLRLRAAVRPEATAVICYTSGTTGAAKGCVISHANLAAECDTLIAGWGHLLA
                     PRGEQPSVLAFLPLAHCYGLMVVVTCVRGGYLLAHQPEMAPAVLLPALASFRPTFLFAV
                     PYIFERIFDEACREAEAAGHGVIFEKARAAAVAHAEAREKHTAGTGHGPGPVTRLRHSV
                     YERAVYAKVRAVFGGRVRSAVSGGSPLRRELGLFFQGAGVTVYDGYGLTETTAAVTAQP
                     PGRVRFGTVGRPLPGSTVRIAGDGEVWVRGDTVFRGYLHDPPGLADGWLATGDTGRFDP
                     DGYLVITGRKKDIIITSGGKSVSPQLLEEQLRRHPLIAQCLVVGDNRPYVAALLTVDQE
                     ALAHWQRLRGASGRAASAPADDTELRAQLQRAVNQANTLVSRAESIRAFEILPVDFTRQ
                     EGLMTPSFKLRRSAVTDTYAEVIEALYAR"
     aSDomain        1840..3192
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BGV78_RS12455_AMP-binding.1"
                     /evalue="2.50E-88"
                     /label="BGV78_RS12455_AMP-binding.1"
                     /locus_tag="BGV78_RS12455"
                     /protein_end="474"
                     /protein_start="23"
                     /score="288.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HTAATYPTRPQLALEPTDHGSPWRTVTAARLRDEVLALARGLLAE
                     GVRPGDRVVLMSRTRPEWTLLAYALWTLGAEVVPVYPTSSIEQVRWVLADASVRAAVVE
                     HSGQAMTIAAACADPGALLGLWQLDLDCTAELAERGAEVPEDEVLRLRAAVRPEATAVI
                     CYTSGTTGAAKGCVISHANLAAECDTLIAGWGHLLAPRGEQPSVLAFLPLAHCYGLMVV
                     VTCVRGGYLLAHQPEMAPAVLLPALASFRPTFLFAVPYIFERIFDEACREAEAAGHGVI
                     FEKARAAAVAHAEAREKHTAGTGHGPGPVTRLRHSVYERAVYAKVRAVFGGRVRSAVSG
                     GSPLRRELGLFFQGAGVTVYDGYGLTETTAAVTAQPPGRVRFGTVGRPLPGSTVRIAGD
                     GEVWVRGDTVFRGYLHDPPGLADGWLATGDTGRFDPDGYLVITGRKKDIIIT"
     CDS_motif       2320..2379
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BGV78_RS12455_0001"
                     /evalue="1.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="BGV78_RS12455"
                     /protein_end="203"
                     /protein_start="183"
                     /score="21.2"
                     /tool="antismash"
                     /translation="AVICYTSGTTGAAKGCVISH"
     CDS_motif       3037..3114
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BGV78_RS12455_0002"
                     /evalue="8.10E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="BGV78_RS12455"
                     /protein_end="448"
                     /protein_start="422"
                     /score="18.3"
                     /tool="antismash"
                     /translation="GEVWVRGDTVFRGYLHDPPGLADGWL"
     gene            3812..4316
                     /locus_tag="BGV78_RS12460"
                     /pseudo=""
     CDS             3812..4316
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640757.1"
                     /locus_tag="BGV78_RS12460"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRIRAVHQAELTALQDIERAAGVCPGDRHGRDRRGRAAAGGPAGA
                     VRAVGARLGGGRQGGPARGVPGRGAGRRQPSRRAGDGASGKCAPGCRAGPAGSRGQAGP
                     ERGGRGADAHHLHRGAVERAVLRAVRLPPAGGARADAGAAGDPAGRGGARTGPVAALLH
                     APGGV"
     misc_feature    complement(4516..4533)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.61"
                     /tool="antismash"
     misc_feature    4899..4914
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.77"
                     /tool="antismash"
     misc_feature    4951..4971
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.44"
                     /tool="antismash"
     gene            5001..5216
                     /locus_tag="BGV78_RS12465"
     CDS             5001..5216
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="BGV78_RS12465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_008412458.1"
                     /sec_met_domain="strepbact (E-value: 2.7e-38, bitscore:
                     125.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYTPQVETAEIADSELDNISGGLVNGLVGSVTSSLDSVAPVSDT
                     LGTVTGVVEQTTGLNTAPVTGLVAGL"
     misc_feature    5015..5030
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            5414..6220
                     /locus_tag="BGV78_RS12470"
     CDS             5414..6220
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640761.1"
                     /locus_tag="BGV78_RS12470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_015506777.1"
                     /transl_table=11
                     /translation="MRFRQQALTKLQSPEQLDLPVRFARPQGLLVLAVTLVVMAAGGVW
                     AVTGSVATTLTAPGVLTHAQGSYVVQSTVSGQVTAVRTAEGRRVARGTPLLTVRTARGD
                     VTIRALAAGRVTALAAATGAVVTTGSDLAAVERQENPDDPLLAVLYAPADSGASLRPGA
                     EVDLTVQSVPAQSYGVLRGTVKSVGRTARTRQQISADLGSTQLGEEFSRNGPPIAVEVR
                     LHPTKSTRSGYTWSTSDGPPQPLTTLTLVDGAVHLDEQRPADWLLP"
     gene            6217..8514
                     /locus_tag="BGV78_RS12475"
     CDS             6217..8514
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640763.1"
                     /locus_tag="BGV78_RS12475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_071338072.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 6.2e-37, bitscore:
                     121.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPADAPAAGTGSTAPPTPGGRRGRRAAPSSGRRRAAPPRRTPR
                     RRPVRTPTVLQMEAVECGAACLAMVLAHHGRHVPLEELRIACGVSRDGSRASNVLKAAR
                     SYGLTAKGMQMEPAALREVRAPAVLFWEFNHYVVHEGFLRRPGRRGAVRLNDPDKGRRV
                     VSAEEFDASFTGVALVLEPGPSFRKGGRKPGLLGALPARLRGTGATLLTALLASLLLVV
                     VGAALPALSRTYIDLFLIGERTSVLGPLFAAMGALVALTASLTALQQANLLRGRIISST
                     LSSARFLRHLLRLPVTFFAQRSPADLVQRLQSNDTVAETLARDLAAAAVDGVVVVLYAL
                     LLWTYDPQLTVVGVGIALLNIVAMRVVIHLRATRTQKLRADNARLTTTAYTGLQLIETM
                     KATGGEDGFFRRWAGQHATTLEEQQRLGVPTAVLSVVAPALATFNSALILWIGGLRAVE
                     GHLSVGLLVAFQALMVRFTAPLTRLNGVAGRIQDFAADVTRLRDVEAFPADGLYRREGA
                     GGGEADTRRLAGRVELEGLTFGYSPLDAPLLTEFSLTVGPGRQVALVGGSGSGKSTVSR
                     LLAGLYQPWEGTIRIDGQSLTEIPRSALAASVSFVDQDIFLFEGTVRENVTLWDPSLSD
                     EAVRTALSDAGLEEVIARRPDGIHARVEQDGRNFSGGQRQRLEIARALVRRPSVLVLDE
                     VTSALDAETEQRVMAALRRRGCACVIIAHRLSTVRDSDEIVVLDGGRVVERGRHAELVA
                     RGGAYAALVEEK"
     misc_feature    complement(8564..8576)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
ORIGIN
        1 gcgggagcga ccggcggcac ctacaccgcc gtgcagcaca aggaggacct ctccgacaag
       61 gtgaagcagc tggtggaccg cgcggccgac ccggtggtca cgccggtgcc ggtcgagggg
      121 gctgcggcct gcgccgacgc gccgaagatc gagccgggcc tgtacaccga ccgccagccg
      181 ctcggcaccc accgctggta ccgggtggac gtgctgcccg gccaggagct gcgcgcctcg
      241 gtgagtgtgg cggccgaccg cccgctcgcc gacgactacg gcgtgctgct gcgcgcggtg
      301 accgcgcacg gccgcgagct ggtgcgcggc tcggaggcgg gcagcggccg gaccgacgtg
      361 atctcgtccg gtctgcgcca cccggagcgg gagcgggagg acgccgacac cgacaagccg
      421 gccgcgaccc cggtctgcct ggaggtcagc aactccttcg ccccggcctc cgccaaggcc
      481 gccgacgcct cggcgccggg tatgccgctg gagctgacgg tcgacgtggt cgacgggccg
      541 tccgacgcct cggacacggc cgccttcggg ctgggccgtg gctggtggct gctgggcgtg
      601 ctggtgctcg ccggtttcct cggcggcctg atcttcggct ggctgtcgcg ctggcgcttc
      661 gccgtctgga ggacccactg atgcgtaccg ttcttcgcag gtcccggtcc gtgccgtccc
      721 ggcgcccgcg cgggcgcgtc gccgtggcgg ccgccctcgc cgcggcggcg ctgttcacgg
      781 ccgcgccgcc ggccctcgcc gacacctcgc cctcgccctc cgtctcgcag gacgaggagg
      841 ccgaggccgg tccgaccgag gcgggcaccg cgttccgcac ggcggcgcgg ctcgcgcagg
      901 ggcagcgcgg caccgcctcc gcgtcgaccg gtgactacct ctactgggtc ttcccggccg
      961 acaccgggca gcgcccgacc gtgcgggcga ccgtgtcgct ccccgccgaa caggcccggc
     1021 agtccgcctc cacctggcgg atcgacgtct acgacggact ccgacgccgc cagccgtgca
     1081 cctacggcct ccaggagcgg cgggccgccg aggacgccgc cgaggtgcgg ctgacctgca
     1141 cgctgcgtac cgtgcgggcc tactccgagc cgtgggccaa cgacccgctg cccggggcgt
     1201 actacgtccg gctgacggtc tcccggctcg ccgccgacga cctgggccgg ccgttccagg
     1261 ccgaggtggc ggtcgactcc cgagagaccg gcggctccac ggcggtcggc gggaagctct
     1321 ccgagccgct gacgcccggc atctcggcgg tctccgccga ggagcaggcc gaggaggaga
     1381 cggccgagga ggacggtgcc gagcaggcgc cgcgtccggc ggcgctcgcc gagcccgagg
     1441 acggctggtc ctccggctgg tggaccgacc ggtggctgtg gacggccggg ggtgccgtac
     1501 tggccgccct ggcgggcgtc ttcggctaca ccctgacccg gggcaacggg cgtcccggcc
     1561 gggtgccgcc cggcgtctga cgggccggcg gctccgcgcg tccccggccg ggcggcgcgc
     1621 ggagccgccc ccggcgcacg gtggtgaact cccccgtcac ccctggccag tgcgtgcggg
     1681 gcgctgtagg ttgccgagcc ggccatccgt caggtacggg ccccgcgctg gtgcggcacg
     1741 cggccgggat gacgaacgga ggcgtacccg gtgcgggaag tgagtgtgga gcgcctggtc
     1801 gccccgccgg tctccggcgg cctcgccgac tcggtcttcc acaccgccgc gacgtacccg
     1861 acgcgccccc aactggccct ggaacccacg gatcacggca gcccctggcg caccgtcacg
     1921 gcggcccggc tccgcgacga ggtactggca ctggcccggg gcctgctggc cgagggggtg
     1981 cggcccggcg accgggtggt gctgatgtcc cgtacccggc ccgagtggac gctgctggcg
     2041 tacgccctgt ggacgctggg cgccgaggtg gtgccggtct accccacctc ctccatcgag
     2101 caggtccgct gggtcctcgc cgacgcgtcc gtccgggcgg cggtggtgga gcacagcggg
     2161 caggcgatga cgatcgcggc ggcctgcgcc gaccccggcg ccctgctcgg gctctggcag
     2221 ctggacctgg actgcacggc ggaactcgcc gagcgcggtg ccgaggtgcc ggaggacgag
     2281 gtgctgcggc tgcgggcggc ggtccgcccg gaggcgaccg ccgtcatctg ctacacctcg
     2341 ggcaccaccg gcgccgccaa gggctgcgtg atcagccacg ccaacctggc cgccgagtgc
     2401 gacaccctca tcgcgggctg gggccacctg ctggcccccc gcggcgaaca gccctcggtc
     2461 ctcgccttcc ttccgctggc ccactgctac ggcctgatgg tggtggtcac gtgcgtacgc
     2521 ggcggctatc tcctcgccca ccagccggag atggccccgg cggtcctcct cccggccctc
     2581 gcctcgttcc ggcccacctt cctcttcgcc gtcccctaca tcttcgagcg gatcttcgac
     2641 gaggcgtgcc gggaggccga ggccgccgga cacggggtga tcttcgagaa ggcgcgggcg
     2701 gccgccgtgg cccacgccga ggcccgcgag aagcacacgg cgggcaccgg acacggcccg
     2761 ggaccggtca ccaggctgcg gcactccgtc tacgagcgtg ccgtctacgc caaggtccgg
     2821 gcggtcttcg gcggacgggt ccgctcggcc gtctcgggcg gctcgcccct ccgccgcgaa
     2881 ctggggctct tcttccaggg cgcgggggtg accgtctacg acggctacgg gctgaccgag
     2941 accacggcgg cggtgaccgc ccagcccccg ggccgggtcc gcttcggcac cgtcgggcgc
     3001 ccactgccgg gctcgaccgt ccggatcgcc ggcgacggcg aggtgtgggt acgcggggac
     3061 acggtcttcc ggggctatct gcacgacccg ccggggctcg ccgacggctg gctggccacc
     3121 ggggacaccg gccgcttcga cccggacggc tatctggtga tcaccggccg caagaaggac
     3181 atcatcatca ccagcggcgg caagagcgtc tccccgcaac tgctggagga gcagttgcgc
     3241 cgccatccgc tgatcgccca gtgcctggtg gtcggcgaca accggcccta cgtggcggcc
     3301 ctgctcaccg tcgaccagga ggccctggcc cactggcagc gcctgcgcgg ggcgtccggc
     3361 cgggccgcct cggccccggc ggacgacacg gagctgcggg cccagctcca gcgggcggtc
     3421 aaccaggcca acaccctggt ctcacgcgcc gagtcgatcc gggccttcga gatcctgccg
     3481 gtcgacttca cccgccagga gggcctgatg accccctcgt tcaaactccg ccgcagcgcc
     3541 gtcacggaca cctacgcgga ggtcatcgag gccctgtacg cccgctgaac ggccgtgcgg
     3601 ggcgggtcgt gagaacctcg cgcgaagaat tgcccgcccc cggccggcat gactcccccc
     3661 gccccgggca cacgcccctc agaccgacct gacgaccctt ccccctggcc tggcaggttg
     3721 cctcggcccc accggacttt ccccccttcg tccggtgggg ccgccccctt ttcccgttgc
     3781 ctcccgcctt cgcgcaccgg accatgcccc catgcgtatc cgagccgtgc accaggccga
     3841 actgacggcc ctccaggaca tcgaacgggc cgccggagtc tgtccgggag atcggcatgg
     3901 ccgagatcgc cgaggacgag ccgccgccgg tggcccagct ggcgcggtac gcgcggtcgg
     3961 ggctcgcctg ggtggcggcc gacagggagg accggcccgt ggcgtacctg gtcgcggagc
     4021 gggtcgacgg caaccttcac gtcgagcagg tgacggtgcg tccggaaagt gcgcgccggg
     4081 gtgtcgggcg ggccctgctg gatcacgcgg ccaggcgggc ccggagcgag ggggccgcgg
     4141 cgctgacgct caccaccttc accgaggtgc cgtggaacgc gccgtactac gtgcggtgcg
     4201 gcttccgccc gctggcggag cgcgagctga cgccggggct gcgggagatc cggcgggccg
     4261 aggcggcgca cggactggac cggtggccgc gctgctgcat gcgccgggag gtgtgagcgc
     4321 gggcgccgag gagagcgcgg ggcgcgaaag ggcggggacg gggaagcgtg cattccccgt
     4381 ccccgccctt tcgcgccctg tggacaattc ccgtccccgc ccctccgctc tcttttctca
     4441 gtgcgcaaga attcgccggg cgaaggcaat cagtccgctt ccgctccttc ttctcctcgt
     4501 ggcggacgct gttcctccac acgttggaaa catgaccttc ccaaagccgt ccgcacacga
     4561 atccgccgca ccccggagcg ggttctcctg cggtgaatct gcacagccgt gccgcagctc
     4621 cgtcaccgcc acccatacct tcaccgggcg tgaacggccg aggtcgacgg cgtgcaccag
     4681 ggcttcacag cgaggggcgc ggtgtacacg cgagcgtgac cccacctggt acggcggcgg
     4741 gacggtgtga aggtggtgcc gttctcctgt gcccgattcc gcacacggtg gtgaggagaa
     4801 cggcaccccc ggccgaattc cgctctcacc gattggccgc cccgcgcacc gtcgtgcttt
     4861 gatccatcgc actgcggcac cgcccccgga tctgaaggtt cacgcctttc gcccgggggc
     4921 cgccagaaga ttttcccctt cttctgcacg agtgcgtcgc ggtgactatt tccgtcagtg
     4981 atgcgaaggg aactcccccc atgagctaca ccccccaggt cgagaccgcc gagatcgccg
     5041 acagcgagct ggacaacatc tccggcggcc tcgtgaacgg cctcgtcggc tcggtcacct
     5101 ccagcctcga ctcggtcgcc ccggtctccg acaccctcgg caccgtcacc ggcgtcgtgg
     5161 agcagaccac cggtctgaac accgccccgg tcaccggcct cgtcgccggt ctctgagacc
     5221 ccacgcgtcg cctgacgacg cgtgcggccc gctgaggcgg accgctcggc cggtgccccg
     5281 gacccgctcg ggttccgggg caccggccgc ctcctttgtc ctccccggac gcccgcgcgg
     5341 cgtccccccg caccacggcg acacccggcc gcacggccga gaggccggtg cccggcagtc
     5401 gaggaagtct tccgtgcgct ttcgccaaca ggccctgacc aagctccagt cgcccgaaca
     5461 gctggacctg ccggtgcggt tcgcccgccc gcagggactc ctggtcctcg ccgtcaccct
     5521 tgtcgtgatg gccgccggcg gcgtgtgggc cgtcaccggc tcggtcgcca ccaccctcac
     5581 cgcgcccggc gtcctcaccc acgcccaggg cagctacgtc gtccagtcca ccgtctccgg
     5641 acaggtcacc gccgtccgca ccgccgaggg ccgccgcgtc gcccgcggca ccccgctgct
     5701 gaccgtccgc accgcgcggg gcgacgtgac catccgcgcg ctggccgccg ggcgggtcac
     5761 cgcgctggcc gccgccaccg gcgccgtcgt caccaccggc tccgacctgg ccgccgtcga
     5821 gcgccaggag aacccggacg accccctcct cgcggtgctc tacgcccccg ccgacagcgg
     5881 cgcctccctc cggcccggcg ccgaggtcga cctcaccgtg cagtcggtgc ccgcccagag
     5941 ctacggcgtg ctgcgcggca ccgtgaagtc ggtcggccgc accgcccgga cccggcagca
     6001 gatctccgcc gacctcggct ccacccagct cggcgaagag ttctcccgga acgggccgcc
     6061 gatcgccgtc gaggtccggc tgcaccccac gaagagcacc cgcagcggct acacctggtc
     6121 gacctccgac ggcccgcctc agccgctcac caccctcacc ctcgtcgacg gcgccgtcca
     6181 cctggacgaa cagcgcccgg ccgattggct cctcccgtga ccgcacccgc cgacgccccc
     6241 gccgccggga ccggctccac cgccccgccc accccgggcg gccgccgggg ccgccgcgcc
     6301 gccccctcct ccggccgccg ccgcgccgcg cccccgcgcc gtacgccccg gcggcggccc
     6361 gtccgcaccc ccaccgtcct gcagatggag gcggtggagt gcggcgccgc ctgtctcgcc
     6421 atggtcctcg cccaccacgg gcggcacgtc ccgctggagg agctgcggat cgcctgcggc
     6481 gtctcccgcg acggctcacg cgccagcaac gtcctgaagg cggcccgcag ttacggcctg
     6541 accgccaagg gcatgcagat ggaaccggcc gccctgcgcg aggtgcgggc ccccgccgtg
     6601 ctgttctggg agttcaacca ctacgtcgtc cacgaggggt tcctgcggcg tcccgggcgg
     6661 cgcggcgcgg tccgcctcaa cgaccccgac aaggggcgcc gggtggtgag cgccgaggag
     6721 ttcgacgcct cgttcaccgg cgtcgccctg gtcctggagc cgggcccctc gttccgcaag
     6781 ggcggccgca agcccgggct gctcggcgcg ctgccggccc ggctgcgcgg caccggtgcc
     6841 accctgctga ccgcgctcct ggccagcctg ctgctggtcg tggtgggcgc ggcgctgccc
     6901 gcgctgagcc ggacgtacat cgacctgttc ctgatcgggg agcggacctc ggtgctcggg
     6961 ccgctcttcg cggcgatggg cgcgctggtg gcgctgaccg cctcgctgac cgccctccag
     7021 caggccaatc tgctgcgcgg gcggatcatc tcctcgacgc tgagcagcgc ccggttcctg
     7081 cgccatctgc tgcggctgcc ggtgaccttc ttcgcccagc gctcccccgc cgacctggtg
     7141 cagcggctcc agtcgaacga cacggtggcc gagaccctcg cccgcgacct ggcggccgcc
     7201 gccgtcgacg gggtggtggt ggtgctgtac gcgctgctgc tgtggacgta cgacccgcaa
     7261 ctgaccgtgg tcggggtggg gatcgcgctg ctcaacatcg tggcgatgcg ggtggtgatc
     7321 cacctgcggg ccacccggac gcagaagctg cgggccgaca acgcgcggct caccaccacc
     7381 gcgtacaccg ggctccagct catcgagacg atgaaggcga ccggcggcga ggacgggttc
     7441 ttccgcaggt gggcggggca gcacgcgacg acgctggagg agcagcagcg gctcggggtg
     7501 ccgacggcgg tgctgtcggt ggtggccccg gcgctcgcca ccttcaacag cgcgctgatc
     7561 ctgtggatcg gcgggctgcg ggcggtcgag gggcatctgt cggtcgggct gctggtggcg
     7621 ttccaggcgc tgatggtgcg gttcaccgcg ccgctgaccc ggctcaacgg cgtcgcgggc
     7681 cgcatccagg acttcgcggc cgacgtgacc cggctgcggg acgtcgaggc gttcccggcg
     7741 gacgggctgt accggcggga gggggccggc ggcggcgagg cggacacccg gcggctggcg
     7801 ggccgggtgg agctggaagg gctgaccttc ggttacagcc cgctggacgc gccgctgctg
     7861 acggagttct cgctgacggt cgggccgggg cggcaggtgg cgctggtcgg cgggtcgggc
     7921 agcggcaagt cgacggtctc ccggctgctc gcgggactgt accagccgtg ggagggcacc
     7981 atccgcatcg acgggcagtc gctcaccgag atcccgcgct ccgcgctggc cgcctcggtc
     8041 tccttcgtcg accaggacat cttcctcttc gagggcacgg tgcgggagaa cgtcaccctc
     8101 tgggacccct cgctgtccga cgaggcggtc cgtaccgcgc tgagcgacgc cgggctggag
     8161 gaggtgatcg cccgccgccc cgacggcatc cacgcccggg tcgagcagga cgggcggaac
     8221 ttctccggcg gccagcggca gcggctggag atcgcccggg ccctggtgcg ccgccccagc
     8281 gtgctggtgc tggacgaggt gaccagcgcg ctggacgcgg agaccgagca gcgggtgatg
     8341 gcggcgctca ggcggcgcgg ctgcgcctgc gtgatcatcg cgcaccgcct ctccaccgtg
     8401 cgcgacagcg acgagatcgt ggtgctggac ggcggccggg tcgtggaacg cgggcgccac
     8461 gccgaactgg tcgcccgggg cggcgcgtac gcggccctgg tcgaggagaa gtgagatgac
     8521 gggcacccag caggcttccc accccacccc ggccgccgac ccggtgacgg cggcactcgg
     8581 cggactcggc gcaccggtgg agggcgccgc agggtcggcc ctgccgctcg gcggcccctc
     8641 ggcgctgtgg ctggtcaccg agggcagcct cgacctcttc gccgtggcgg ccgccgagga
     8701 cggccactgg cactacctcg gccgcctgga ggccggcacg ctcctgctcg gcgccgtcga
     8761 gggcccccgc cacaccctgg tgggccgcct ctcctcccgc tgcgccgtac gccgcctgcc
     8821 gctgcgcgag ctgtacgcgc cgcagggggc cgaggggtac cccgggtacg agccggtcgc
     8881 cgggccgctg gagcgcgcgg tggggctcgg cctcggccgg gggctcgccg tgctgttcgc
     8941 ggcaccgcag gcggacgggc ccgcggcggg gtccgggccc gccgacgagg acgtgctgtg
     9001 ggtggacgtc ccgccgggca gtgtccggct gggggccgag ttcgccgccg aggccgcggc
     9061 cgacctgctg gtcgacgggg cgctgtggca gtccctggtg gaccagcagt accgcctgct
     9121 gaccgccgtc gacggctggg tggagcggct ggagcgggcc cacgaggacc gggcggcggc
     9181 cggtatccgc gccggtgagg cggtacggga gcgggccgac caggcgctgc tcgactcgat
     9241 cggccgccgc gaccgctccc cgagggcgcg cggcgaggcg ggcgacgacg cggtgtacgc
     9301 ggtcttccgc caggtggcgc gggcgagcgg catcgcgctg ccggaggcgg cggcgcgttc
     9361 ggtcgcgggc ggcgggcggc tcgacccggt ggagcggatg gccgccgccg cccggctgcg
     9421 gacccgcccg gtccggctgg ccggcgagtg gtggcgcacc gacgccgggc cgctggtggg
     9481 gcggcgcgcc aggtccggcg cgccggtggc cctgctctgg cggcgcggcc ggtacgaggc
     9541 gctcaacccg gcgaccggcg cccggatccg gatcggcgcc aaggaggcgg ccgagttcga
     9601 ggaacgcgcc accatgctct accggccgct tcccgagggc ccgctgacgc tgcgccggct
     9661 gatgttcttc agcctgcgcg gctcccgggg cgacctgcgc aacctcgtcc tgagcggcct
     9721 ggtcaccgtg gcgctgggcg cgctggtgcc ggtggcgacc gggcaggtgc tcggcgcgta
     9781 cgtgcccagt gcgcagaccg ggctgatcgc gcagatgtgt gtggcggtga tggtggccgg
     9841 ggtggtctcg gcggcgttca tgctgctcca gtcgttgacg ctgctgcgtc tggaggggcg
     9901 gatcgaggcg gcgttgcagc cggccgtctg ggaccggctg ctgcggctgc cgacggcctt
     9961 cttcgcggac cgctccaccg gtgagctggc cagtgccgcg atgggcatca gcgcgatccg
    10021 ccgggtgctg tcggggatcg ggccgaccgc cgtgcagtcg gtgacggtgg ccggggtcaa
    10081 cctggtgctg ctgctggtgc acagcgtgcc gatggcgctg gcggcgatcg gcgtgctgct
    10141 ggtggtctcg gtggtcttcc tgctgctggg gctctggcag gtgaagtggc agcgcaagct
    10201 ggtggagctg ggcaac
//
