LOCUS       NZ_CP017708            10879 bp    DNA     circular CON 27-FEB-2024
DEFINITION  Moorena producens JHB chromosome, complete genome.
ACCESSION   NZ_CP017708
VERSION     NZ_CP017708.2
KEYWORDS    RefSeq.
SOURCE      Moorena producens JHB
  ORGANISM  Moorena producens JHB
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Oscillatoriales; Oscillatoriaceae; Moorena.
REFERENCE   1  (bases 1 to 9648523)
  AUTHORS   Leao,T., Castelao,G., Korobeynikov,A., Monroe,E.A., Podell,S.,
            Glukhov,E., Allen,E.E., Gerwick,W.H. and Gerwick,L.
  TITLE     Comparative genomics uncovers the prolific and distinctive metabolic
            potential of the cyanobacterial genus Moorea
  JOURNAL   Proc Natl Acad Sci U S A 114 (12), 3198-3203 (2017)
   PUBMED   28265051
REFERENCE   2  (bases 1 to 9648523)
  AUTHORS   Ngo,T.-E.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2022) Scripps Institution of Oceanography,
            University of California - San Diego, 8615 Kennel Way, La Jolla, CA
            92037, USA
  REMARK    Nucleotide sequence updated by submitter
REFERENCE   3  (bases 1 to 9648523)
  AUTHORS   Leao,T., Castelao,G., Korobeynikov,A., Monroe,E.A., Podell,S.,
            Glukhov,E., Allen,E., Gerwick,W. and Gerwick,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2016) Scripps Institution of Oceanography, UCSD,
            9500 Gilman Dr, La Jolla, CA 92093, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-JUN-2022
            Assembly Method                   :: Flye v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 20.0x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/27/2024 02:50:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,304
            CDSs (total)                      :: 8,236
            Genes (coding)                    :: 7,971
            CDSs (with protein)               :: 7,971
            Genes (RNA)                       :: 68
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 265
            CDSs (without protein)            :: 265
            Pseudo Genes (ambiguous residues) :: 0 of 265
            Pseudo Genes (frameshifted)       :: 95 of 265
            Pseudo Genes (incomplete)         :: 172 of 265
            Pseudo Genes (internal stop)      :: 109 of 265
            Pseudo Genes (multiple problems)  :: 87 of 265
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:39:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3681528
            Orig. end                         :: 3692407
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017708.2.
            On Feb 2, 2023 this sequence version replaced NZ_CP017708.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerwick Lab Culture
            Collection, UCSD, SIO.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10879
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="18"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10879
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10879
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5879](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5879
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(<289..774)
                     /locus_tag="BJP36_RS15855"
                     /old_locus_tag="BJP36_14675"
                     /pseudo=""
     CDS             complement(<289..774)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009149329.1"
                     /locus_tag="BJP36_RS15855"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="BJP36_14675"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIVLQFKAIGKQKQYLAIEEAMITAKIVRNSCIRYWMDNKGVGK"
     misc_feature    1199..1212
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.06"
                     /tool="antismash"
     gene            complement(1431..3704)
                     /locus_tag="BJP36_RS15860"
                     /old_locus_tag="BJP36_14680"
     CDS             complement(1431..3704)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015147414.1"
                     /locus_tag="BJP36_RS15860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP36_14680"
                     /product="adenylate/guanylate cyclase domain-containing
                     protein"
                     /protein_id="WP_071104324.1"
                     /transl_table=11
                     /translation="MWQPLKQQLWEWRGVLITTPVVAGIAIAFRLLGWLQPYELAALDQ
                     YFCWRPKEPTDERIVIVAMTEADLKRAGRWPITDRMLARLLDKIKAQNPAAIGIDLYRD
                     FPVEPGHGDLLKVFETTPNLVAIEYIDQDNPDNSVAPPPILSERGLVGANNVLNDMDGI
                     LRRSLLTLKVNDRLQPSFSMLLAGIYLESKNTFPEPLQQDPRIFQWGKAMFRPFASNDG
                     GYVGIDDGGYQILLNYRGAAGTFRTVTMTDVLEDNIPDHLINDSIVLIGATAVSLNDFF
                     YTPYSNDTTMRESTAGVEVQANMVSQIISAVEDGRPLLKTWSEPVEILWIVGWSFVGAT
                     LTWKWRYLGGLGGLSLRRTAITVVATGALFGSTYGAFFKGWWLPVIPPLLALSGSAVAI
                     TGYVASTAKEIRHTFGRYLTDQLVADLLENPDKQKLGGENRKITILTSDLRGFTAISER
                     LHPQEVVKILNIYLGHMAEVITAYQGTIDEFMGDGILVLFGAPTLQEDDAHRAVACALA
                     MQLAMTSVNEQIEQLGYPKLEMGIGINTGVVVLGNIGSEKRTKYSVIGSAVNLTYRIES
                     YTTGGQVMISPSTLEEIGAFLRIDGQKQVKAKGIKQPITIYEVGGIGHNYNLFLTKDQE
                     TFFDVNQKIELQFNYAFLDGKHISNSVYTGRLVEISSKGAKLRANSSESSAIPEPLSNI
                     KLNLLDPDNLNQPSDDIYAKVLEKTAEPGSFYIRLTAVPPEISARLESLYQSAKVIDPK
                     FSEV"
     misc_feature    complement(3855..3870)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.48"
                     /tool="antismash"
     gene            4423..4743
                     /locus_tag="BJP36_RS15865"
                     /old_locus_tag="BJP36_14685"
     CDS             4423..4743
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021559.4"
                     /locus_tag="BJP36_RS15865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP36_14685"
                     /product="DUF2282 domain-containing protein"
                     /protein_id="WP_071104325.1"
                     /transl_table=11
                     /translation="MKDMKKTVMVSAALTSVLALGLGVASENALAGKEGMEKCAGIVKE
                     GQNDCGANGHACAGMAAVDSDPNEWIYVPEGTCDKIVGGTIVPPKTSSQETEKPTESAQ
                     AN"
     gene            5001..5879
                     /locus_tag="BJP36_RS15870"
                     /old_locus_tag="BJP36_14690"
     CDS             5001..5879
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008181411.1"
                     /locus_tag="BJP36_RS15870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP36_14690"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_071104326.1"
                     /sec_met_domain="DUF692 (E-value: 2.1e-93, bitscore: 311.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHVPSASINGAGIGLRSAHYQDILTHKHSIPWFEVLLDNYLTS
                     QGLPLHYLEKVRQNYPVTLHGVGMSLGSTDPLDLEYLTNLKQLAQQIEPAYISDHLSWI
                     SVNGHYLNDLIPLPYTEAVMEHVAQRILQAQEFLGCRILIENPSAYVSFTDSTMPEWVF
                     IQQLLEKADCYLLLDVNNLYVTATNQGFDPLDYLNTIPATRVKQIHLAGYEEREDYLYD
                     THGYPVHPPVWELYQATLERFGPVPTLIEWDTDIPAFEVLMTQASKAQDYLDKHSAVSR
                     QPSALGHRPIS"
     gene            5993..6772
                     /locus_tag="BJP36_RS15875"
                     /old_locus_tag="BJP36_14695"
     CDS             5993..6772
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008181412.1"
                     /locus_tag="BJP36_RS15875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP36_14695"
                     /product="DNA-binding domain-containing protein"
                     /protein_id="WP_071104327.1"
                     /transl_table=11
                     /translation="MELRTLQQLFYDAVFENNPASTQTIAPHIKAAKQLTPAEGLAIYR
                     SSVLGNLSQTLMSIYPVCCCLVGEKFFDGTAISYIQRFPSISMDLGDYGEHFPDFLANF
                     EPAKQLPYLPDVARLEWHWHRVFNGEEATKLDVQALSTVPQEKWGELIFHLPKNSVLIE
                     SAYPIHRIWEVNQPEYEGDQQVNLDEGGIQLFLWRNGYDMRIELPTKAEWQLLKAFQGE
                     NRFEAICQDLAADELAIDVASELPQFVQRGWIARFSI"
     misc_feature    6821..6835
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.65"
                     /tool="antismash"
     misc_feature    complement(6938..6951)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    complement(7403..7421)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.57"
                     /tool="antismash"
     gene            7617..8558
                     /locus_tag="BJP36_RS15880"
                     /old_locus_tag="BJP36_14700"
     CDS             7617..8558
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009786247.1"
                     /locus_tag="BJP36_RS15880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP36_14700"
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_071104328.1"
                     /transl_table=11
                     /translation="MSVTLTTTSLSLTTALPLTGHPARVYLSSLSPGSQPTMRQALDMI
                     ASLLTNNECDADTLDWAALTYQHTAAVQAALLEINSPATVKKKMAALRGVLAVAKKLKL
                     MDPEDYEAAVDLPKIKNHALPRGRALTQTEITALIEVCTSDTTNQGARDKALIGILRGT
                     GLRRAEVVKLEVRDFDGDSGALEVRQGKGGKDRTVYLPEGAIAFVDNWLSVRGHQPGAL
                     LCPIQKGGQIQYRKMTPQAVLLILQKRAKQAGVESFSPHDFRRTFCSDLLDAGIDIVTV
                     QKLAGHASPVTTAKYDRRGEEVKRRAVQKLGF"
     misc_feature    9870..9885
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
ORIGIN
        1 actacttcac cacaattaga acaatttcga ctagtgcaga gcctttcttt tttcgagaaa
       61 ctcgacgttg atagaacttt agacgctttt ccccttttct ataaaaccta ggtaagggta
      121 cagtattgct attcggtgtt gctggaacag actcattgat atcgatctga aggcaaaact
      181 gaacatatag cactacgcat taaagttagg acatggctaa aagctgaaaa cctgttgtag
      241 taaacttttg acttctgact tgtgacttct gacgctaagc gtagcgctat agtaaccatc
      301 ggctcgacgg actatcctaa ccctcttgat tacctttttg tcaaagcgcc ataaattcca
      361 tgttcctttg aatttgagtt ttccaatccc ttttttttca ctaaaaatga ttgacttatc
      421 tggacataat ttccatccat aagtcttgta ttcaactgag tgacaatgtt tttttaatct
      481 agaaaaacct ttctttccgg gaactttttt cttacagttt tcgtataaac ggggaattga
      541 tgaccatgct cgttcagcac tggtgagggg gaccatagag ttcaattcat tggcaaacgg
      601 gaactgatga gctaagacag tgcaatattt gttgaggtct catttcccaa cacctttatt
      661 gtccatccaa tagcgaatac agctattgcg aacaatttta gctgttatca tcgcttcttc
      721 tattgctaaa tattgctttt gtttgccaat tgccttgaac tgtaaaacaa tcattagtat
      781 cgacctttaa ctactaaagt agtctacact acacaaagga aaatttccgg aaatagaaaa
      841 atatttttct tacggcgcgt caagccgctg ttagccttca tccccggtga ttagacaggg
      901 ggttttcggc tttgggggat tttgataatt ttttggtgcc atgggtttct aagctcaaat
      961 cccgctcact agtttgcctg taggagggac gcaatcaaag gtttacgcag ccatggatac
     1021 agggtttttc gaacgtaagc attcagccgt cagcctaatg ccgtgagcta aaagctcacg
     1081 ctacttgagg tgcctaatgc cgtcagctga cgtaacagag attaaagcaa tgcttacttg
     1141 ttttattcaa aagcacctca agtagcgtgc gtggcacagg ctttggcctt ggccgttggc
     1201 cacgctacgc gaatggccac gctgtgcgaa cgacgctggg aggtagcgca ttagctgata
     1261 gctgatagct gatagctatt agctgatagc tgatagctat tagctgatag ctgatagctg
     1321 aatacttact ttcgaacagc gattaaccgg agtttcaatc agatcaaatt ccctgtacca
     1381 aagtaacttt ttatacccgg aacccttgac ccaactcaag agtgactaaa ttagacctca
     1441 gagaacttag gatcaattac ttttgctgac tggtagagag attctagtct tgctgatatc
     1501 tcgggaggga cagcagttaa ccggatgtaa aaacttcccg gttctgctgt tttttctaaa
     1561 accttggcgt agatatcgtc actgggttgg ttgagattat ctggatctag taagttgagc
     1621 ttaatattgc tcaggggctc agggatagca gagctttcgc tgctgttagc acgaagctta
     1681 gctcccttac ttgaaatctc tactaaacgt ccagtgtaga ccgaattact gatatgcttt
     1741 ccatctagaa aagcataatt aaattgtagc tcaatttttt ggttaacgtc gaaaaatgtt
     1801 tcttgatctt tggttaaaaa taggttataa ttatgcccaa ttccacccac ttcatagata
     1861 gtaattggct gtttaattcc cttggctttt acctgttttt gaccgtcaat tcttaagaat
     1921 gcgccaattt cttccaaagt ggaaggagaa atcataactt gaccaccagt tgtataagat
     1981 tcgatccggt aagtcaggtt gacggcgctg ccaatcacac tatatttggt gcgtttttcg
     2041 gaaccaatat tcccaagcac aaccacaccg gtattgatac cgatgcccat ttccagtttt
     2101 ggatagccca actgctcgat ttgttcattg acactggtca tggctaactg catcgctagg
     2161 gcacaagcca ctgctctgtg ggcatcatct tcttggagag tgggagcacc aaaaagcact
     2221 aaaatcccat cccccatgaa ctcgtcgata gttccttgat aagcagtaat cacttccgcc
     2281 atgtgaccca aatagatgtt gaggattttg actacctctt ggggatgtaa ccgttctgag
     2341 atcgcagtga agcctcttaa atcagaggtc aagatggtga ttttgcggtt ttcacccccg
     2401 agtttttgtt tgtctgggtt ctccagcaaa tccgccacca attggtcagt taggtaacgt
     2461 ccaaaggtgt gacgaatctc tttagcagta ctagcaacgt aacctgtgat ggcaactgca
     2521 gacccactta aggctaacaa tggcggtatc accgggagcc accaaccctt gaaaaatgct
     2581 ccataggtac ttccgaataa tgcccctgta gcgaccacgg taatggcagt tctcctcaag
     2641 gacagccctc cgagaccgcc aagatagcgc catttccaag ttagagtggc accaacgaaa
     2701 gaccagccta caatccacag gatttccaca ggctcagacc aggttttgag caagggacga
     2761 ccatcttcta cagcactaat aatttggctg accatgttag cttggacttc caccccagcc
     2821 gttgactccc gcatggtagt gtcattactg tagggggtgt agaaaaagtc atttaaactg
     2881 accgcagttg caccaattaa aacaatggaa tcattgatca agtgatctgg aatgttatct
     2941 tccaaaacgt cggtcatggt tacggtgcgg aaggttcccg ctgctccccg atagttcaac
     3001 aaaatctggt agccgccatc atcgattccc acataaccac cgtcattgct ggcaaaaggg
     3061 cgaaacatgg ccttccccca ctggaaaatt ctgggatctt gctgtaatgg ttcaggaaaa
     3121 gtgttttttg actctagata aatccccgct aggagcatac taaaggaggg ctgtaggcga
     3181 tcattgacct tcagagtaag taagctgcgc cgcaggatac catccatatc gtttaggaca
     3241 ttattggcac ccactagacc acgttcactg agaatcggtg gaggagccac ggaattgtca
     3301 gggttgtctt gatcgatgta ttcgatagca actaagttgg gtgtggtttc aaacaccttg
     3361 agtaagtcac catgaccggg ttcaaccgga aaatcccgat acaggtcaat accaattgct
     3421 gcaggatttt gagctttgat tttgtctaaa agtcgggcaa gcatccgatc agtgattggc
     3481 caccgtccag cacgctttaa atctgcctca gtcatagcca caatcacaat ccgttcatcc
     3541 gtaggttcct tcggacgcca acaaaagtat tggtcgagag cagctagttc gtaaggctgt
     3601 aaccagccga gtagcctgaa agcgatcgca attccagcca ccaccggtgt agtaattaga
     3661 acaccgcgcc attcccatag ttgttgtttt agtggttgcc acatatagca gttttcaatt
     3721 aggtgaggta ctttcgttct gggttttagg gagcagggag caggcaagag gcaataggca
     3781 agaggcaata ggcaagaggc aataggcaag aggcaatagg caataggcaa taggcaatag
     3841 gcatgctagc aagagtgaaa aaatcctgtg tacctcaggt gcgacccgtg gcgaatttaa
     3901 ttcttaatgg taagagcgca cctaatagtt atgaaaaacg ctgtattaca gttgaatgtc
     3961 tactaacctc aaaaaattct ttcttctgga aagggttatt gacaatgata gagctatggg
     4021 tcactacaag tgtattagtg ggtgcatctc aatgtatgca aaaacactca gcacaataca
     4081 aggctaatat catgttatga tatatatcct taataaaaat ctaccctatc tccccatctc
     4141 cccatctccc catctcccca ccctccccac acttccggga gtgatagatt tacaacaaga
     4201 agctgatagc tgatacgcga cacgctgata gctgatgttt caaatgtcct atcctatttt
     4261 aataactttc tcagggttat ctcagacttt tcaaagactc ggttaagtta ggttaaatac
     4321 cttaaataat aattacatag atagtaatta aaccaagatt gttttagttt aattctgtct
     4381 acggacttac gagtcagttc tgatattcgg gagagttatg tcatgaaaga tatgaaaaaa
     4441 accgtaatgg tgagcgctgc cttgactagt gtcttggctc taggtttagg tgtagcatct
     4501 gaaaacgcct tggccggtaa ggaaggaatg gaaaaatgtg ctggtatcgt taaggagggt
     4561 cagaacgatt gtggagccaa cggccatgct tgcgcgggga tggctgcggt agatagcgat
     4621 cccaatgagt ggatctacgt tcctgaaggg acttgcgaca agattgttgg tggaactatt
     4681 gtaccaccaa aaacctccag ccaggaaact gaaaagccaa ccgagagtgc ccaagccaat
     4741 taaaggaagc tatcagcagg ctgcgcactc agctatcagc ttatgaatca tggctgagta
     4801 gtgttatgta cacagatccc ccctaacccc ccttaagaaa ggggggaatt agattcaaaa
     4861 gtcctgcttc cgcgcggggg ataatggggg atctcaatca ggtattaaca aaactgaaat
     4921 gcttcctgct gatatcttac tattaccatg gataagtcct aaaaaccatg ccatgaaaac
     4981 aatgtcatca aaacaatgct atgacaactc acgttccttc agcttcaatt aacggtgctg
     5041 gaatcggttt acgctctgcc cattatcaag atatccttac tcataaacat agtatacctt
     5101 ggtttgaggt attattagat aattatttaa cgtctcaggg tttaccactc cactatttag
     5161 aaaaagtccg ccaaaactat ccggttacgt tgcatggcgt cggtatgtct ttggggtcaa
     5221 ccgacccttt ggatttagag tatttgacaa atttaaaaca gttagcccag cagattgaac
     5281 cagcatacat ttccgatcac ctatcctgga tttccgttaa cggtcactat cttaacgatt
     5341 taattcctct tccttatacc gaagcggtga tggaacatgt agcccaacgg atattgcaag
     5401 ctcaggaatt tctaggttgt cggattttga tagaaaaccc atcggcttat gtgagcttca
     5461 cagattcaac catgccagaa tgggtattta ttcaacaatt gttagaaaaa gcagattgtt
     5521 acttgctgct agatgtcaat aatctttatg tcactgctac taaccaagga tttgaccccc
     5581 ttgattattt gaatacaata ccagcaacca gggtcaaaca aattcactta gcagggtatg
     5641 aagaacggga agactatcta tatgataccc acggttatcc cgttcatcct ccagtctggg
     5701 aattgtatca agcaacatta gagcgctttg gtccggtgcc tactttgata gaatgggata
     5761 ctgatatccc agcttttgag gtattaatga ctcaagctag taaagctcag gactatttag
     5821 ataagcattc agccgtcagc cgtcagccgt cagcccttgg ccacaggccg attagctgat
     5881 agctgatagc tgatagctga tagctgatag ctgatagctg atagctgata gctgatagct
     5941 gatagctgat agctgatagc tgatagctta cgtatttaga tcaggtaaat agatggaatt
     6001 aaggacacta caacagctat tttacgatgc tgtttttgaa aataatcctg ccagtacaca
     6061 aaccattgct ccacacatca aagcagctaa acaattgacc cctgctgaag ggttagcgat
     6121 ttatcgtagc agtgtcctag gcaacctgag ccaaacctta atgtcaattt atccagtctg
     6181 ctgttgtttg gtgggagaga aattttttga tggaacagcg ataagctata tccaacggtt
     6241 tccttctata tcaatggatt taggagatta tggcgagcat tttcctgatt ttctagccaa
     6301 ttttgagcca gcaaaacagt taccatattt accagatgtg gccaggttag agtggcactg
     6361 gcatcgggtg tttaatggtg aagaagctac caagttagat gtccaagcat tgagtacagt
     6421 tccccaagaa aaatggggag aactaatttt ccatttacct aaaaatagtg ttctgatcga
     6481 gtcagcttac ccgatccatc gcatttggga agttaatcag cctgaatacg aaggtgatca
     6541 gcaagtcaat ttagatgaag gggggataca actattcctc tggcgcaatg gttatgatat
     6601 gcgcattgag ctgccaacaa aagcagaatg gcaactgctg aaagcttttc aaggagaaaa
     6661 tcgatttgaa gcaatttgtc aagacctggc tgctgatgaa ttagctattg atgtagcatc
     6721 tgagctaccg caatttgtcc aacgtggatg gattgctagg ttttctattt agacatatcc
     6781 ttatggaaat tcccacaagc caaaaccccg cgtttttaaa ccaccggatg taggctcgct
     6841 gcgactttag tcgcctagac acaattttgc caaaaaaggt tgacaatacc tgcgcgctat
     6901 agtcatattt agatatgggt acaggctgca aatccgttcg cgtagcgtgg cctttggcct
     6961 tggcgcaacc gggagagaga cccgccactg cttgacctta aagaagaaat gcccggaggg
     7021 tagggaaaat cctccttaaa aacccaatca tcaattaaaa gttggtgtgt gaacctagaa
     7081 gaacacattt tgagaaaaga aaaagtacgg tggggcacac cgaaacttag ggaaaatgga
     7141 agcaacggac tttttaaggc acttccaagg taaagtacct taacgcctaa ggagaactgc
     7201 cctctaggtc tttcgtgaat tgactggaaa cttggtctac gtacgggttt ttggttaagt
     7261 attgtccaat ttttggcggc gtcaagaaga ggaacacgaa ggtttacggc ggttcgttga
     7321 tctaggaatc cccgcgcctt gtggcctacg gcctccgcta cgcgaacagg ccggggagtg
     7381 tcaaagacag ttacccacgc caataggtga gccgacccat agatttggca ttctctgaag
     7441 ttttcaaggt gcttcagagc aagcagctgt tcgtcctgta ttactctgtt atatatatac
     7501 tacaaaatat actacaaaat gtcaataatg taatacaaaa tagtgattcc cttagagcat
     7561 tgagtgaccc aatatgtgaa ataattactt ctcagaagca cccttctcat aagccaatga
     7621 gtgtaaccct caccactaca tcactctctc tgaccacagc tttaccgttg actgggcatc
     7681 cggcacgggt ttatttgagt agtttgagtc ctgggtcgca accaacaatg aggcaagctt
     7741 tggatatgat cgcatcccta cttactaata acgaatgtga tgcggatacc cttgactggg
     7801 cagccctcac ctatcagcac accgctgccg tccaagccgc attactagaa atcaattccc
     7861 ccgccacggt caagaagaag atggcagccc tcaggggagt cttagctgtg gcaaagaagt
     7921 taaaactgat ggatccagaa gattatgagg cggcggtgga tttacccaag attaagaatc
     7981 atgctttacc tagaggtcgg gcattaactc aaacagaaat tacagcactt attgaggtgt
     8041 gtacttccga tacaactaat caaggggcta gggataaagc tctaattggt atcctacggg
     8101 gtacaggact gcgacgggca gaggtggtga agctggaagt gcgagatttt gatggtgata
     8161 gtggtgcatt ggaggtgcgt cagggtaaag gggggaagga taggacggtt tatttaccgg
     8221 aaggtgcgat cgcttttgtt gataattggt tgagtgtcag aggtcaccaa ccaggggcgc
     8281 tcttgtgccc aatacagaaa ggtggacaga tacagtacag aaaaatgacc ccccaggccg
     8341 tgttgttgat tttgcagaaa cgagctaaac aggctggggt ggaatccttt agtccccatg
     8401 attttcgcag gaccttctgc tctgatttgc ttgatgctgg gattgatatt gtgacggtac
     8461 agaagttagc tggccatgct tcccctgtga ctacggctaa gtacgatagg cgaggggagg
     8521 aggttaagcg tagggcggtg cagaagttgg ggttttagga ggaggggcaa aggccataat
     8581 gtttcctgcg gatagggttg gcgatgggga gaggatcatt acttggtcac acaaggccta
     8641 tatcctgtag gactagtaat ggtgttttca ccacgcgacg acgaagagct ggagacagtc
     8701 aagtccatcg ttaagaaatc ttacgaatat gctactgggg aagcgccaag gtagtattgt
     8761 aacaaaggtc taaaagtaag cggtcattgt taaatcatct tcaaaattgt ctctgataag
     8821 cctggggagt tcccatatta ctgggttacg caccttttgg taagtaattg ttttctacaa
     8881 aaatgcatat tatgtttaag ctcactgaaa acaaaagacg gcaacttctg ttttcaatga
     8941 aaacacttca ggagagtcaa taatcatgac aaccactggt ggtaaatgtc cggtgataca
     9001 cggtagtgta acaacaaata gtatgtcaga gatggagtgg tggccgaagg cacttaatct
     9061 cgatattttg agtcagcatg atcgcaaaac tgatccgatg ggagtggact ttaactatcg
     9121 ggaggcggta aaaaaacttg atgtggttgc actaaaacaa gacctacatg cgctgatgac
     9181 cgacagccaa gattggtggc cagcggattg gggtcactat ggtggtctga tgatccgtat
     9241 gacttggcac gcagccggaa cctaccggat tgcggatggt cgtggcggtg cggggacagg
     9301 taatcaacgt tttgcgccac tcaactcctg gccagacaac gccaacctag acaaggcacg
     9361 ccgtctactc tggccgataa agaagaagta tggaagccag cttagttggg ccgatttgat
     9421 tacctatgct ggcacgatcg cctacgaatc catgggacta aaaacctttg gtttcgcctt
     9481 tggtcgagaa gatatctggc atcccgaaaa agatatttac tgggggccag aaaaggaatg
     9541 gcttgccccc agcgataacc accacagccg ctattctgat gagcgaaagc tagaaaatcc
     9601 actggctgcg gtaacaatgg ggttgattta tgttaatccc gagggtgtag atggcaatcc
     9661 cgaccctatc aaaaccgcca atgacgtgcg cgttaccttt gcccgtatgg cgatgaacga
     9721 cgaagaaacc gtagccctta cagctggggg gcatacggtg ggcaaatgtc acggtaacgg
     9781 tgatgccggg ttgctgggcg tggaacccga aggggcagat atccaagacc agggcttggg
     9841 gtgggtgaac aatactggtc agggtattgg tcacaacacc gttaccagtg gtatagaagg
     9901 agcctggacg cctcagccga ccctgtggga taatgggtat tttcatatgc tgctcaacta
     9961 tgactgggaa ctaaagaaga gtccagcagg tgcgtggcaa tgggaaccga ttgacccgaa
    10021 ggaagaagac aaacccgtca atgttgcaga tccgacgatt cgcggcaacc ttgtaatgac
    10081 cgacgctgat atggccatga agatggaccc aaagtatcga aagatttccg agcggttcta
    10141 caacgatcct gaatatttca gtaatgtctt cagacgggca tggttcaaac tgacccaccg
    10201 agatatgggg ccaaaggctc gctatattgg ccccgatgtt ccagaagagg atctgatctg
    10261 gcaagatcct attccagccg ggaatactga ttacgatatt caagccgtaa aggaatgcat
    10321 tgcagtaagc ggtctgagcg ttagtgaaat ggtttgtacc gcttgggaca gcgctcgtac
    10381 atttcgcgga tcggacaagc gcggtggcgc aaacggggcg cgaattcgtc tgactccgca
    10441 gaaggattgg gaaggcaatg agccagctcg tttggcaaaa gtattaactg ttctagacag
    10501 cattgcagca gagactaagg caagtatagc ggatgtcatc gtcttggccg gtaacgtagg
    10561 tatcgaacaa gctgctcaag ccgctggctt cgaaattacc gtcccctttt ctccggggcg
    10621 gggcgatgca acggatgaga tgaccgacgc agagtcattt gacgtgctag aacccattca
    10681 tgatggctac cgcaattggt tgaagaaaga ctatgccgtc agtgcggaag agcttatgct
    10741 tgatcgcacg cagttgatgg gactgacggc tcccgagatg actgtgttag tcggtgggat
    10801 gcgtgtgtta gggaccaatt atggcggcac aaagcatggc gtattcacgg atcgtgaagg
    10861 tgctttgact aacgacttc
//
