LOCUS       NZ_KV804815            21143 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Rothia sp. HMSC065G12 Scaffold160, whole genome shotgun sequence.
ACCESSION   NZ_KV804815
VERSION     NZ_KV804815.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Rothia sp. HMSC065G12
  ORGANISM  Rothia sp. HMSC065G12
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Micrococcaceae; Rothia.
REFERENCE   1  (bases 1 to 924343)
  AUTHORS   Mitreva,M., Pepin,K.H., Mihindukulasuriya,K.A., Fulton,R.,
            Fronick,C., O'Laughlin,M., Miner,T., Herter,B., Rosa,B.A.,
            Cordes,M., Tomlinson,C., Wollam,A., Palsikar,V.B., Mardis,E.R. and
            Wilson,R.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2016) McDonnell Genome Institute, Washington
            University School of Medicine, 4444 Forest Park, St. Louis, MO
            63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Velvet v. 1.1.06
            Genome Coverage                   :: 144x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001811455.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 12:58:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,178
            CDSs (total)                      :: 2,120
            Genes (coding)                    :: 2,076
            CDSs (with protein)               :: 2,076
            Genes (RNA)                       :: 58
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 4 of 44
            Pseudo Genes (incomplete)         :: 39 of 44
            Pseudo Genes (internal stop)      :: 2 of 44
            Pseudo Genes (multiple problems)  :: 1 of 44
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:45:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 42607
            Orig. end                         :: 63750
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KV804815.1.
            The WUSC is a large strain collection isolated from clinical
            samples. Each sample is associated with metadata, including source,
            isolation site, 16s rRNA, metabolic, and other phenotypic
            information. The goal is to sample an adequate number of important,
            yet minor species, further adding to the catelogue of sequenced
            bacterial genomes and improving the diversity of the genomes
            available to the public. WGS will be preformed on approximely 550
            isolates. Samples were selected based on RDP analysis at the genus
            level. This is a reference genomes for the Human Microbiome Project
            and the work was funded by the National Institutes of Health (NIH)
            grant U54 HG004968.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21143
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21143
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21143
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11143](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11143)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            506..1942
                     /locus_tag="HMPREF2804_RS05500"
                     /old_locus_tag="HMPREF2804_05485"
     CDS             506..1942
                     /EC_number="1.8.1.15"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004371.1"
                     /locus_tag="HMPREF2804_RS05500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05485"
                     /product="mycothione reductase"
                     /protein_id="WP_048751980.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.5e-41, bitscore:
                     136.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIKELEIIDGVAQYDLIVIGSGSGNTLIGPEWDTKKVALIDGGT
                     FGGTCLNVGCIPTKMFVYPATTAQKARELNKLGIEAEITAINWAQIRDRIFPQRIDKIS
                     AGGRDWRAGLPNVDYYPEYAHFVDAHTVQTESGQKLYGRQVVIAAGSRAVLPAVPGIDL
                     PQVHTNDTIMRLEELPKRLVVLGGGVVAAEFSHVFSALGAQVYQMVRSNRILREVDVEV
                     VDRFVEAASHQWNILLERSLVEIRENGDGTVTVVVEHNGEVEEIVADIVLAATGRRSNS
                     DTLKASSFFDVDSRGFIGTDKYQRVLYNGSPVPGVFALGDVSSPFQLKHVANHEARTVQ
                     HNLSHSDSFVASDHRFVPAAVFSNPQIATVGLSEENARKLGEREGFEVTVKSQNYGDTA
                     YGWAMEDSVGLAKLIARKDTGQLLGAHLVGEEASVLIQPLIQAMSFGLGVKDMARGQYW
                     IHPALTEVIENALLGLDVDN"
     gene            complement(2024..4120)
                     /locus_tag="HMPREF2804_RS05505"
                     /old_locus_tag="HMPREF2804_05490"
     CDS             complement(2024..4120)
                     /NRPS_PKS="Domain: AMP-binding (22-469). E-value: 3.6e-88.
                     Score: 287.8. Matches aSDomain:
                     nrpspksdomains_HMPREF2804_RS05505_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005506583.1"
                     /locus_tag="HMPREF2804_RS05505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05490"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_239664739.1"
                     /sec_met_domain="AMP-binding (E-value: 4.5e-88, bitscore:
                     291.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIVSVPAEAMVDPALNLTSIVERHASDTSNPVLYRWQMSPGNWQ
                     DIHAHQFHDMVVSVAKGLIAHGVKPGDRIGIMSRTRFEWALIDFAIWYAGAISVPIYET
                     NAPAQVAWALSHSEAQAIFVENDKLVQITDKAHKFHPLNIKNRWVIENGDLDMLIRAGL
                     DVSDAELEAARTHAHADSLATIVYTSGTTGKPKGCALTHGNFLNLSLNTRIAEPEIANP
                     RSSSLIFLPLAHVLARFIQVLALDSGVVVGHSPTIKNLAADLDSFKPTMLLVVPRVFEK
                     IYEGALAKAARGGTINENLFKRAVKVAIAWSEAKVSGRLPLKLAAQYALYDKLVYTKLR
                     AAMGGKLRYAVCGGGPLSPRLNHFYHAVGVRVVEGYGLTETCAPIAAGRISNFQIGAIG
                     PLLPGSQGRLAEDGELELRGIGVMKEYYKNPAENAQSFTDDGWFKSGDLARFDDQGLLK
                     IVGRKKEIIVTAGGKNVIPGTAENHLRTSPLVSQAMLVGDQKPFIAALVTLDPDTLPDQ
                     LEHLGLPRSLSMPEAAVHPAVRAAIQRIIDEANQLVSRAEAIREFRIMGKDLTEADGYL
                     TPSQKLKRAKILQDFSAYVDDIYSRVSESANNKLERLQSYAEQASDRLQEFKTEKTEKL
                     HDLKVEATERLEEFKGQAAEKLSQHQPVRATPSDKERTYPDGKEHVHGDSEQQKAPRIS
                     SEES"
     aSDomain        complement(2714..4054)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HMPREF2804_RS05505_AMP-binding.1
                     "
                     /evalue="3.60E-88"
                     /label="HMPREF2804_RS05505_AMP-binding.1"
                     /locus_tag="HMPREF2804_RS05505"
                     /protein_end="469"
                     /protein_start="22"
                     /score="287.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ERHASDTSNPVLYRWQMSPGNWQDIHAHQFHDMVVSVAKGLIAHG
                     VKPGDRIGIMSRTRFEWALIDFAIWYAGAISVPIYETNAPAQVAWALSHSEAQAIFVEN
                     DKLVQITDKAHKFHPLNIKNRWVIENGDLDMLIRAGLDVSDAELEAARTHAHADSLATI
                     VYTSGTTGKPKGCALTHGNFLNLSLNTRIAEPEIANPRSSSLIFLPLAHVLARFIQVLA
                     LDSGVVVGHSPTIKNLAADLDSFKPTMLLVVPRVFEKIYEGALAKAARGGTINENLFKR
                     AVKVAIAWSEAKVSGRLPLKLAAQYALYDKLVYTKLRAAMGGKLRYAVCGGGPLSPRLN
                     HFYHAVGVRVVEGYGLTETCAPIAAGRISNFQIGAIGPLLPGSQGRLAEDGELELRGIG
                     VMKEYYKNPAENAQSFTDDGWFKSGDLARFDDQGLLKIVGRKKEIIVT"
     CDS_motif       complement(2810..2884)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HMPREF2804_RS05505_0002"
                     /evalue="8.00E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="HMPREF2804_RS05505"
                     /protein_end="437"
                     /protein_start="412"
                     /score="11.9"
                     /tool="antismash"
                     /translation="GELELRGIGVMKEYYKNPAENAQSF"
     CDS_motif       complement(3515..3574)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HMPREF2804_RS05505_0001"
                     /evalue="4.90E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="HMPREF2804_RS05505"
                     /protein_end="202"
                     /protein_start="182"
                     /score="25.2"
                     /tool="antismash"
                     /translation="ATIVYTSGTTGKPKGCALTH"
     gene            complement(4149..5012)
                     /locus_tag="HMPREF2804_RS05510"
                     /old_locus_tag="HMPREF2804_05495"
     CDS             complement(4149..5012)
                     /NRPS_PKS="Domain: Abhydrolase_1 (60-166). E-value:
                     7.8e-12. Score: 37.2. Matches aSDomain:
                     nrpspksdomains_HMPREF2804_RS05510_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398828.1"
                     /locus_tag="HMPREF2804_RS05510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05495"
                     /product="carboxylesterase"
                     /protein_id="WP_048751979.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-11, bitscore:
                     41.1, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.6e-07, bitscore: 26.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIFENAGEPFRRIRRQARQRRELAIQPSIMRAQSSLESEFNHDP
                     ISHPADRELYEGDVGILIIHGFTGSPHSMRPIADHFIKLGYPVEMPRLAGHGTHWRDMV
                     ATEYKEWVDGVEEGYWKLLNAGYRVIVIGISMGGCIAANLAARHDVLGMVLINPYFVDV
                     NPMMKVAHRVAPIFPSLKSVGSDIARPGVDEGAYPRTPTVSVRQLHLLGRETRELIPLL
                     RAPVLYLRSLHDHVVSDSSHRYFLEHCSAPVNFKWLTHSYHVPTLDYDAELVLSVIQDF
                     VVDCEA"
     aSDomain        complement(4515..4832)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HMPREF2804_RS05510_Abhydrolase_1
                     .1"
                     /evalue="7.80E-12"
                     /label="HMPREF2804_RS05510_Abhydrolase_1.1"
                     /locus_tag="HMPREF2804_RS05510"
                     /protein_end="166"
                     /protein_start="60"
                     /score="37.2"
                     /tool="antismash"
                     /translation="ILIIHGFTGSPHSMRPIADHFIKLGYPVEMPRLAGHGTHWRDMVA
                     TEYKEWVDGVEEGYWKLLNAGYRVIVIGISMGGCIAANLAARHDVLGMVLINPYFVDVN
                     PM"
     gene            5352..6101
                     /locus_tag="HMPREF2804_RS05515"
                     /old_locus_tag="HMPREF2804_05500"
     CDS             5352..6101
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004374.1"
                     /locus_tag="HMPREF2804_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05500"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_070627651.1"
                     /transl_table=11
                     /translation="MTLAYSTLKFLSTPILHSLYRHEIIGLENIPQGPVIIASNHLAFC
                     DSVFIPLALDRPINFLAKSDYFTTSGVKGRAMAKFFTSMGQLPMDRSGGVKSQESLARG
                     LRVLESGGILGIYPEGTRSPDGRGYRPKVGVARLALESGVSVVPVGQIGTDLVQPLGTN
                     RPHLRNRGQKITIRTIFGKPLDFSSRSHEAHLFSVQREIADRVGVAIRELSGQEYVDVY
                     ADAVKKLMASDSLTAEQAVNRLCAECP"
     gene            6220..7581
                     /locus_tag="HMPREF2804_RS05520"
                     /old_locus_tag="HMPREF2804_05505"
     CDS             6220..7581
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004375.1"
                     /locus_tag="HMPREF2804_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05505"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_013398830.1"
                     /transl_table=11
                     /translation="MSNANHNHQLGADYGLDTWRNLHIDQQPTWANHADFDATVAELSS
                     LPPLVFAGEVDSMREQLAEVAEGRAFLLQGGDCAETFEGATAYKISGRIKTLLQMAAVL
                     TYGASMPVVKMGRMAGQFSKPRSSDTETRGDVTLPSFRGETVNGFEFTPEAREHDPKRM
                     LRGYHTSSATLNLVRAFTKGGFADLRAVHQWNRGFTSNPAHERYEQTADEIGRALKFME
                     ACGVDFDALKTTDMYVGHEALVLDYERSLTRIDSRTDLPYDTSAHFLWIGERTRGIDDA
                     HVDFLSKVRNPIGVKLGPTTTAEDALALIDKLDPNREPGRLTFITRMGAKNIREKLPPI
                     VAGVQAAGAQVIWVTDPMHGNTISVPSGYKTRRFDDVLDEVRGFFEVHDALGSFPGGIH
                     VEMTGDDVTECLGGSDAIDEEALADRYESLCDPRLNHSQSLEIAFLVSEYLRNR"
     gene            complement(7662..9326)
                     /locus_tag="HMPREF2804_RS05525"
                     /old_locus_tag="HMPREF2804_05510"
     CDS             complement(7662..9326)
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398831.1"
                     /locus_tag="HMPREF2804_RS05525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05510"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_070627653.1"
                     /sec_met_domain="Pkinase (E-value: 2.2e-43, bitscore:
                     144.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHTPQPNSGSSVPGPAPQTNYKQPLRLTGQVLEKHYLMGRMIAR
                     GGMSEVYYASDLWSNNPVAIKVLTPELAEQAENRQKFHREESSLRKIGGGHTVGVLSSG
                     TEYLQGQRIMYIALEYVYGCTLSQLLRSRQALSMGEGLEILLPVVEGLSEVHAHRYVHL
                     DMKPGNILLDTQRRIKLADFGLTRRNDQYDSGVLMGTPAYVAPEILDPQGRVGAPADIF
                     ALGVMMYRIFSGRLPFTGLHNDQQVLYHNANIEMPPITEVAPGIDPDIAGIIRWCTRKQ
                     ADARPEDATELFTALSEIAQRMNPKDRAWRSPHLEPSELALWDEVGDIAERSGMAQMVR
                     DTPISAYGSAVDLILDVDAENSVIDDFGVPLSPAVHEQGHIGIGPEPHGPDESLISPPS
                     STPSAPANLHNALQPEPSPVPRSESPSTQHVPQQEKSMSKEQLDDESFSAYADPQQIYD
                     RRNSSVPVQANQEQNSSLDSEQSWISQTQERERRHILDPRFPTESLAEPPSATAWSLAA
                     LVVVVLFMAAGFTGWMLATSVLQAAWWQDFSRLFGGL"
     misc_feature    complement(9329..9342)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 20.4"
                     /tool="antismash"
     gene            9524..9892
                     /locus_tag="HMPREF2804_RS05530"
                     /old_locus_tag="HMPREF2804_05515"
     CDS             9524..9892
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398832.1"
                     /locus_tag="HMPREF2804_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05515"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_004004377.1"
                     /transl_table=11
                     /translation="MTNENIAQTFALVGEWVTIPEIAEILDLKITRIHNLLSDGSLIAL
                     RDPETNVRKVPALFLNGNRVLESLKGTLVVLKDSGFSDEEAIVWLYTDDDSLPGRPIDA
                     LKDGRKTEIRRRAQALAW"
     gene            complement(10001..11143)
                     /locus_tag="HMPREF2804_RS05535"
                     /old_locus_tag="HMPREF2804_05520"
     CDS             complement(10001..11143)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398833.1"
                     /locus_tag="HMPREF2804_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05520"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_070627655.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.6e-37, bitscore:
                     123.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEQPKPENLSDGVKSEQEAYLRAVEATMSEFFAQQRTLLTAISH
                     DALPLLEAIESLSSGGKRLRALLGYWGWRGAGGDSILEGSAPTPIIRAGAALELFQSAA
                     LIHDDIIDRSDTRRGKPSVHKKFETQHIQNSWVGDTFNYGLTGGIIAGDLCLSWSEQMF
                     SSIGEGALSGTEARNIFDTMRTEVMAGQYLDVLSEVIPAETPENALARAHRVIQYKSAK
                     YSCEHPLVLGGALALTGIAHQDHPILGKYRAFGLPLGEGFQLRDDELGVFGEPSATGKP
                     AGDDIREGKRTVLIALTAQNISAEDRRMLEGALGNPELTNQQISKIRELMIGSGALEHV
                     EELIAQKSEAVDTALHALPVSEPIRCALSAIAAKALHRKA"
     misc_feature    11173..11189
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     gene            11312..12646
                     /gene="dinB"
                     /locus_tag="HMPREF2804_RS05540"
                     /old_locus_tag="HMPREF2804_05525"
     CDS             11312..12646
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="dinB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004379.1"
                     /locus_tag="HMPREF2804_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05525"
                     /product="DNA polymerase IV"
                     /protein_id="WP_048751976.1"
                     /transl_table=11
                     /translation="MNQQQGRVVMHLDMDAFFVNVELLESPELQGAPIIVAPQGPRAVV
                     CSSSYEARIYGVRSGMPLSRALSLCPAAVVMPLRGNYRYYSQAVMDILRTESPLVEQVS
                     VDEAFVDLTGAVIHGTSPVDIAQRVRSRIAEELHLPSSAGISVNKLIAKMASTGSKPNG
                     LWVVPPAKVREFLDPLPVSKLWGVGSKSAAALGKYGITTIAGLRELDISWLRARFGRAA
                     GEHLWATSRGLDSRDVVPYREEKSIGAEHTFGTDTTSGYEITDALRSLSFKVGIRLRRA
                     RKLAGSLSLKIRYEGFETHTKSVPLSVSCDSGMEIYRASHAALRGMGLLAFSAEQSQEY
                     ATRAIRLIGVRAEKLERSELGVQYPLFDDAILLDLEAGSKHLEDTVGDDRFRPGAWNGI
                     RNAPDWSAVEHTLDSIRQKFTDAAVSSASDLSYIHKSSPEKQKTS"
     gene            12903..13322
                     /locus_tag="HMPREF2804_RS05545"
                     /old_locus_tag="HMPREF2804_05530"
     CDS             12903..13322
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004380.1"
                     /locus_tag="HMPREF2804_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05530"
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_004004380.1"
                     /transl_table=11
                     /translation="MALSEREQKVLDQLEELMSAEDPHFASSMSSTGNTAPVFSARHMA
                     LGILGVLAGLGIIIGAVASKMIWLGIIGFIIAAGGVYLATTSKKTPVDSFLGDKAQGAT
                     QARQEGAGSSEKSTKQSKFMSRLEERWDDRNRGEN"
     gene            13569..14000
                     /gene="mraZ"
                     /locus_tag="HMPREF2804_RS05550"
                     /old_locus_tag="HMPREF2804_05535"
     CDS             13569..14000
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mraZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005507741.1"
                     /locus_tag="HMPREF2804_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05535"
                     /product="division/cell wall cluster transcriptional
                     repressor MraZ"
                     /protein_id="WP_004004381.1"
                     /transl_table=11
                     /translation="MFLGTYTPRLDTKGRIILPAKFRDELSAGLVLTRGQERCLYVFPV
                     AEFERIHETMRSSPLPGRQARDFMRMFLSGASDEVPDKQGRVTIPPVLREYAGLSQELT
                     VIGSGSRAEIWDSKAWEEYMAQTEAEFASLDEDPFAPIL"
     gene            14087..15166
                     /gene="rsmH"
                     /locus_tag="HMPREF2804_RS05555"
                     /old_locus_tag="HMPREF2804_05540"
     CDS             14087..15166
                     /EC_number="2.1.1.199"
                     /GO_function="GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004382.1"
                     /locus_tag="HMPREF2804_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05540"
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="WP_256388193.1"
                     /transl_table=11
                     /translation="MIAESHSLTGVVTPTHDVSTSPNAVSGDPGYREGLLGQLSQRQAQ
                     ERHVPVMLDRCLELLEPAISRQDAVVIDGTLGMGGHTEAMLERFSNLTVIGIDRDAQAH
                     AIAAERLARFGNRFVPVHTVYDHIEDAMSAAGVTSVDGVLLDLGVSSMQLDERSRGFAY
                     SYDAPLDMRMNGDDELTARIVVNEYSENQLRRIIKNWGEEKFAARIAQHIVEQRKHAPF
                     TTTGELVAVIQTAVPAAAQRKGGHPAKRTFQALRIEVNHELEALERAVPAALDALRLGG
                     RFVAMSYHSLEDKIVKCALTEAATSKAPKGFPVELDEHQPTIRVITRGAEPPTEAEIAE
                     NPRAASAKLRAGEKIKVSS"
     gene            15250..16227
                     /locus_tag="HMPREF2804_RS05560"
                     /old_locus_tag="HMPREF2804_05545"
     CDS             15250..16227
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF2804_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF2804_05545"
                     /product="hypothetical protein"
                     /protein_id="WP_135007633.1"
                     /transl_table=11
                     /translation="MTPPQHSPSVTTPEAPTVTGVEETPRTANRRRGTRNANLRIIPEH
                     KPAQKHPTRRGVPGRNKPASNVKSRVSQIQVPRTSVTSDTHARIAHRAQNRLSEHVTAY
                     AGPRTGGAQHPRTIGYPAKSAYPARSIAAKSSRVKAQARETRRVPLALSLVRPRSWSPV
                     ALVGVFVAIPLTLVFILMLNILIATRQYDLVDLRTQEQTLTQENQALQQEIGYQQAPQN
                     LANRASSLGMHATDIPATLDINSGQINGTATPVAKPKDDAPGARNLVDAPAVPSQGSRA
                     STSATPSAAPSASADKQQPASSASASSSASAKPSASTNPSASQR"
     gene            16278..18125
                     /locus_tag="HMPREF2804_RS05565"
                     /old_locus_tag="HMPREF2804_05550"
     CDS             16278..18125
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398837.1"
                     /locus_tag="HMPREF2804_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05550"
                     /product="penicillin-binding protein 2"
                     /protein_id="WP_070627657.1"
                     /transl_table=11
                     /translation="MSFHENAPVPPEPQQLGRRGFVVGALATGGLAAVGARLLYLQGFD
                     PQHTAEKSREKRMRSQIVPAVRGQILDINGVVLARSVQRYNIIADQTIVASYKRYDNDR
                     DTKSEITPEQLVYELTDILHTVDPTITDEFIKSKLDGDSKYAVVKSNVTPEIFRRIDAL
                     GAPFLYGEAISERLYPNGPVGGSVVGRYRIVDEATGNENETIKKNLSVGIERVFEKDLA
                     GVDGQRTYEISADGVRIPVTKEEATDVENGKNVRLTINQDIQYFAQQIVKARVDELKAE
                     WGTVIVMDVRDASILAMADSTMMDPGAEKVKNEQDTSPRAISQVVEPGSTEKILTASAL
                     IESGITTPTSAYDVPERLVINGQTFTDAFDHPAQRRTFSGIITDSMNTGTVLVGKKLPK
                     EDRYNWLKKYGMGDYTGIELTGEQQGLVSDWHEWDGRQEYTVFFGQGIAQTPLQTAMIF
                     QALGNNGVKLKPRIVDALIDADGTVHKRDVEPGTRMVSEKTAEQCRELMENVVLQSHAK
                     TASVEGYRVGGKTGTAEAPSDKGGYDGYTTSFIGLAPIDNPQFLVSVTLQRPQGDVRSV
                     GATSQFSQIMEKVLHTYNVPKSTTDPVKIPIFADGKSNG"
     gene            18253..19971
                     /locus_tag="HMPREF2804_RS05570"
                     /old_locus_tag="HMPREF2804_05555"
     CDS             18253..19971
                     /EC_number="6.3.2.13"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008765 -
                     UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate
                     ligase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013398838.1"
                     /locus_tag="HMPREF2804_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_05555"
                     /product="Mur ligase family protein"
                     /protein_id="WP_070627660.1"
                     /transl_table=11
                     /translation="MDSETRLAQDARRTPHLGGDAQSLRPQNSRGSTVTELVEHLETLG
                     AHPVLEHQGSEEDVRGISMDSRAVRPADLYVALPGAKAHGAQFAQKALEAQAHAILTDT
                     AGARMIREANLSLDGCSLLVCDSLRPVIGSLAALIYGSQDYKGLNRYAVTGTNGKTTTT
                     YMLESVFRTALKAKTGLIGTIQILVDGVSVPSALTTPESVHVHSLLAIMGERGVSHAAM
                     EVSSHAIDYHRVDGVVYKVSGFTNLTQDHLDLHGTMQNYFDSKAQLFTPERTERAVITA
                     DDEWGEKMLRHAQIQLGTGNVVRLVTEHGAGLAEVPAEFGSLDWAVTNVERDGLGHRFT
                     LANGAGDTIPCCTHLPADFNVSNAALAALMVYIGASEEERIILRPALADGTALTPIVPG
                     RMQLISLAPHTIVDFAHNPDGLTRALEAMDRPGGGRVIIVFGATGERDHLKRPLMGEIA
                     AQHADIVIVTDDDPHGEDPAPIREAVVAGAERAIAGGARASQILNLAPREVAIARAIEF
                     ADARDAILIAGRGHETAQDVAGTDVQLDDRVETAKALVSNDFEILPDYRRMLEEA"
     misc_feature    complement(20870..20888)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.07"
                     /tool="antismash"
ORIGIN
        1 atcgactgcc caccgttttt agggaccctt acagcaactg gatggggtgc aagccagcga
       61 gtgctttcga ttgcggagcc ttcacttttc tctgtggcgg gtactgagcg taccctccgt
      121 gcgattgtta ggttccagaa ggacgagaat agttctgttg aggctgctgc cgttgtcgtg
      181 aataaattac gtgccgacga tcccgagcac agctatcggt atgaagaatt gaaggcactc
      241 ttcgggcagc ttgttgctga gcctacgttc aacgaggaag ctgttattca acgtgctctt
      301 ggggcagcac atccgattca cttctggccc gacgaagaag ctgtggagcc ctccatacga
      361 tttacacgtc tgcttgccgg actcatggca gcactgtaga acctaagtaa ttggttgcct
      421 gcctgcaccc cggaataaaa tctggggtgc agcgttgtat tgttcgtatt aagactcaag
      481 taatttttat tgcaggtgag ggactatgag tatcaaagag ctcgaaatta ttgatggcgt
      541 agcacagtac gaccttatcg tcatcggttc gggatcgggg aacaccctga taggaccgga
      601 atgggatacc aaaaaagtag cgcttataga cggcggtact tttggcggaa catgcctgaa
      661 cgttgggtgc atccccacga aaatgtttgt gtacccggca actactgcgc agaaagcacg
      721 tgagctcaat aagttaggca ttgaggctga aattactgca attaactggg cacagatacg
      781 cgatcgtatt ttccctcagc gcatcgataa aatttctgct ggtgggcgtg actggcgcgc
      841 tggtctacct aatgtggatt actaccccga atacgctcat tttgttgatg ctcacacagt
      901 gcagacagag tccgggcaga aactttacgg tcgccaggtt gtaattgctg cgggttcgcg
      961 ggcggttctt ccggcggttc ccggtattga cttaccacag gttcatacaa acgacacgat
     1021 tatgcgtttg gaggagctcc ctaaacgtct tgtagtgctt ggtggcgggg ttgtcgctgc
     1081 tgagttctca cacgtattct ctgctttggg ggcacaggtc tatcagatgg tccgttctaa
     1141 ccgtattctc cgtgaggtag atgtagaagt tgtagacagg ttcgtagaag cagcatctca
     1201 ccagtggaac attctcctgg aacgctctct tgtcgaaatc cgcgagaatg gcgatggaac
     1261 cgttaccgtt gtggttgaac acaatggtga ggtagaggag attgttgcgg atattgtact
     1321 tgccgcaact ggtcgccgct ccaatagcga tactcttaaa gcatccagtt tctttgacgt
     1381 cgatagccgc gggtttattg gaactgataa ataccagcgc gtactgtata acggttctcc
     1441 cgtacctgga gtattcgcgc taggtgatgt ctcctcgcca ttccaactca agcatgtggc
     1501 gaaccatgag gcacggaccg ttcaacataa cctcagccac tccgatagct tcgttgccag
     1561 cgatcatcgt tttgtccctg ctgcggtttt cagtaatccg cagatagcaa ctgtgggact
     1621 ctcagaagag aacgcccgga agctgggaga gcgtgagggc ttcgaagtta cggtgaagag
     1681 ccagaactac ggcgataccg cttatggatg ggctatggaa gattccgtgg gattggcgaa
     1741 acttattgcc cgcaaagaca cgggacagct cttaggcgct caccttgtag gggaagaagc
     1801 ctcagtgttg atccagccgc ttattcaagc catgagcttc gggttaggcg tgaaagacat
     1861 ggcccgtggt cagtattgga ttcaccctgc tctgactgaa gttatagaaa atgctcttct
     1921 tgggctagat gtagataact agttttcata tataaagctg tggggcccct ccccaacctt
     1981 ggtgagaacc ccacagcttt tagcctcttt tcgcattcaa gagctacgat tcttccgaag
     2041 agattcgtgg agctttttgt tgttctgaat ctccgtgcac gtgctcttta ccatcagggt
     2101 atgtacgctc tttatctgaa ggtgtggctc ggactggctg atgctgagat aacttttccg
     2161 ccgcttgccc tttaaactct tcaagacgtt cagtcgcttc aaccttcaga tcatgaagtt
     2221 tttctgtctt ctctgttttg aactcttgga gcctatcaga agcttgctcg gcgtagcttt
     2281 gcagacgttc gagtttatta ttagcgcttt ccgaaacacg gctatagatg tcatccacat
     2341 aagcagaaaa atcctgcaga atcttagccc gtttgagctt ttgagaaggt gttaaatagc
     2401 cgtccgcctc cgtcaaatcc ttacccataa tgcggaattc gcgaatagct tctgcacgag
     2461 ataccagttg attagcctca tcaataatgc gctggatcgc ggcgcgcacg gcaggatgca
     2521 cggcggcctc tggcatagaa agggaacgcg gaagccccaa atgctcaagc tgatcgggga
     2581 gagtatcggg atcgagagta accaaagccg caataaaggg tttctggtct cccacgagca
     2641 tagcctgaga taccaaggga gaagttcgta gatggttctc cgcagtgccc ggaataacat
     2701 tcttgccccc ggccgtcacg atgatttctt ttttgcgccc cacaattttg aggagccctt
     2761 gatcatcgaa acgggctaga tcaccgctct tgaaccatcc atcgtcagtg aaagactggg
     2821 cattttcagc gggatttttg tagtattcct tcatcacgcc gattccacgc agttcaagct
     2881 cgccatcttc ggcaagacgg ccttgagaac ctggcaggag cggaccaata gccccgatct
     2941 gaaaattgct gatgcgcccg gcagcaatcg gcgcacatgt ttccgtgaga ccataaccct
     3001 caaccactcg gactcctacc gcatggtaga aatgattcaa ccgtggggag agaggcccgc
     3061 ctccgcagac tgcgtaacgt aatttaccac ccatagcggc acgcaatttt gtgtaaacta
     3121 gcttatcgta gagtgcatat tgtgccgcca acttgagggg gagtcgtcca gaaactttag
     3181 cctcagacca agcgatggcg accttaaccg ctcgcttaaa aagattttcg tttatggttc
     3241 cgccacgagc cgccttagcc aatgctccct cataaatctt ttcaaagaca cgcggtacca
     3301 ccagcaacat ggtgggctta aaactatcca ggtcagccgc aagattcttg atggtagggg
     3361 agtgcccaac aacaaccccg gaatccaaag caagaacctg aataaacctt gccagaacat
     3421 gcgctaaagg taagaaaata agggaagaac tacgcggatt agcgatctcc ggctccgcga
     3481 tgcgcgtgtt aagactcaaa ttaagaaagt ttccgtgcgt gagcgcacat cctttaggct
     3541 tacctgttgt tccagacgtg tagacgatgg ttgcaagcga atcggcatgg gcatgtgtgc
     3601 gtgccgcttc aagttcggca tcggagacgt ctaaacctgc tctgatgagc atatccaaat
     3661 ccccattttc aatgacccaa cgatttttaa tattgagcgg gtgaaattta tgcgccttat
     3721 cagtaatctg aaccagttta tcgttctcca caaaaattgc ttgtgcctca gaatgcgata
     3781 aggcccaggc aacttgtgcg ggtgcgttcg tctcgtagat aggtaccgat atggctccgg
     3841 cataccagat agcaaaatct attaaagccc actcaaagcg ggtgcggctc ataataccta
     3901 tgcgatcacc aggtttaacg ccatgcgcaa tgagtccctt ggctacagaa accaccatgt
     3961 catgaaactg atgtgcgtga atgtcctgcc aattgccagg cgacatctgc caccgataca
     4021 gcactggatt tgaggtgtcg gaggcatggc gttccacaat actggtgaga ttcaacgctg
     4081 gatctaccat agcttctgcg ggtacggaga caatttgcat acaaggcctt tcaacgctgt
     4141 agcttggatt atgcttcaca gtcaacgaca aaatcttgta tcacggataa gacaagttcc
     4201 gcgtcgtagt ctagagtcgg cacatggtaa ctgtgagtca accatttaaa gtttaccggt
     4261 gctgagcagt gttctagaaa atagcggtgc gaactatctg agacaacatg atcatgaagg
     4321 gaacgcagat aaagcaccgg agctcgtagc aagggtatca gctcacgagt ctctcggccc
     4381 aaaaggtgaa gctgccgtac agaaacggta ggagttcgcg gatatgcacc ttcatcaact
     4441 ccaggacggg caatgtcaga tcccacagat ttgagcgaag gaaatatagg ggcaactcgg
     4501 tgtgccactt tcatcatggg gtttacatcc acaaaatagg ggttaatgag caccatgcct
     4561 agaacatcat gccgagccgc taaattggca gcaatgcacc cgcccataga aataccgatt
     4621 acgataaccc gatagcctgc attgaggagt ttccaatatc cttcttcgac accgtcaacc
     4681 cactctttat actcggtcgc caccatgtct cgccagtgtg tgccatgccc agcaagacga
     4741 ggcatctcaa cagggtagcc gagcttaata aagtgatctg ctataggtcg catactgtgc
     4801 ggggatcctg tgaagccatg aatgatgaga atgccaacat caccctcata gagttcacgg
     4861 tcagccggat gggaaatagg atcgtggttg aactccgact ctaaagagct ttgcgcacgc
     4921 attattgagg gctggatggc aagctcacga cgctgacgtg cctgacggcg gatgcggcga
     4981 aacggttcac ctgcattctc gaaaatactc atggcatcct ttcaacagta cactctcact
     5041 ttgagacttg gaaccgttca agagttgaaa taggttcgtg gtcaattatt acctacagct
     5101 ctgggataac accgtctgag ctacgctaag agcgcgaaaa cgataatatt cacagataac
     5161 tatcagacaa aagtcacctc ggcgtcggga aagaggggat ttcggcacgg tactgctaaa
     5221 accgttacaa tctaatcacg tagaggtttc gcattgttgc cgtcctctcg tgatatgtgc
     5281 tcgctaacca catccgtcat atacgggtac gcgtgcctat cccgcattta ttgttttatg
     5341 acggaagagc tatgaccctc gcctacagca ccctcaaatt tcttagtacg cccattctgc
     5401 atagtctcta tcggcatgag attatcgggc ttgagaacat accccaggga ccggtcatta
     5461 ttgcaagtaa ccacctagca ttttgcgatt cagtttttat acctcttgcg ctcgatcgcc
     5521 ctattaattt cttggcgaaa agtgattact tcacaacatc cggtgtcaaa ggtcgcgcta
     5581 tggctaaatt ttttacaagc atgggtcagc ttccgatgga tcgttccggt ggggtcaaaa
     5641 gtcaagaatc tcttgccaga ggccttcggg tgctagaatc aggcggcata ctggggatct
     5701 atcccgaagg cacccgcagt cctgacgggc gtggctaccg tcccaaagtt ggagtagcaa
     5761 ggttagccct tgaatctgga gtttctgttg taccagtagg gcagattggt acggacctgg
     5821 tgcagccgct gggaacaaac aggccgcacc tgcgcaatcg cggacaaaag ataacgattc
     5881 gtacaatttt tggaaagccg ctagatttct ccagcagaag tcacgaagcg catcttttct
     5941 ccgtacagcg tgagattgcg gatcgtgtag gtgtagctat tcgtgagctt agcgggcaag
     6001 aatatgttga tgtgtacgcg gatgcggtga aaaaactcat ggcgtccgac agcttaaccg
     6061 ccgaacaggc tgtaaaccgt ctgtgtgcag agtgcccata aacttatcta agactgcgcc
     6121 atatgctcag atacggcatt ttaggaaggt acaataatct ttatcctttg atgccgcgtc
     6181 agcgtgctga accatacaga aattctggag tacacaccca tgagcaacgc gaaccataac
     6241 caccagcttg gcgcagatta cgggttggat acctggcgga atctgcatat agatcagcag
     6301 cctacatggg caaatcacgc tgattttgac gcaactgttg ccgagctgag ctctctgccc
     6361 ccgttagttt ttgctggtga ggtagattct atgcgcgaac agctggcgga agtagccgaa
     6421 ggacgtgcgt tcttgctaca gggtggtgac tgtgccgaaa cttttgaagg tgccacagcc
     6481 tacaaaatct ctggtcgcat caaaactctt ctccagatgg cggcggttct tacctacggc
     6541 gcttcgatgc ctgtggtgaa gatgggtcgt atggctggcc agttctcaaa gccacgttcc
     6601 tcggatacgg aaacacgtgg cgatgttact ttgccttcct tccggggcga aaccgtcaac
     6661 ggttttgagt tcacgcctga agctcgtgag catgatccta aacgtatgct gcgcggctac
     6721 cacaccagtt ccgccaccct taaccttgtg cgtgctttta caaaaggtgg ctttgcagat
     6781 ctacgcgcgg tacatcaatg gaaccgcggg tttacttcaa acccagcgca tgagcgatac
     6841 gaacaaacag ctgatgaaat cggccgcgcc ctcaaattca tggaagcctg tggggttgat
     6901 tttgatgcgc tcaaaactac cgatatgtat gtggggcatg aggctttagt ccttgactat
     6961 gaaaggtccc tcacccgtat cgattcacga accgacttgc cctatgacac ctcagcccat
     7021 ttcttgtgga ttggtgagcg aactcgtggg attgatgatg cgcacgtgga tttcctctct
     7081 aaagtgcgta accccatcgg tgtaaaactc ggtcccacaa ccaccgctga agatgcactg
     7141 gcccttatcg ataaacttga cccgaatcgt gaacccggtc gcctcacttt tattacccgt
     7201 atgggggcta agaatattcg agagaagttg cctcctatcg tcgcaggggt acaagctgct
     7261 ggtgcacagg ttatctgggt aaccgatcct atgcacggta atacaatttc cgttccttct
     7321 ggctataaga cccgccgttt tgacgatgta ctggatgaag ttcgcggttt cttcgaggta
     7381 catgatgctc tcggctcatt ccctggcggt attcacgttg agatgaccgg ggatgacgtt
     7441 actgaatgcc taggtggctc agacgctatt gatgaagaag ccctagctga tcgttatgaa
     7501 tctctttgcg atccccggct gaatcactcg cagtcgcttg aaatcgcgtt cttggtatcc
     7561 gagtatctca ggaaccgata agcaatgtag ttttagcttt atgctgaagg tcgcatagaa
     7621 ctttacagag tttctatgcg accttcgcat atgggattac tctataatcc gccgaaaagc
     7681 ctggaaaaat cttgccacca ggcggcctgc agtactgatg tggcgagcat ccagcccgta
     7741 aaaccagccg ccataaagag aacgaccacc actaatgcgg cgaggctcca cgctgtagct
     7801 gaaggtggct cggcaagaga ctcggtaggg aatcgaggat caagaatgtg ccgacgttcg
     7861 cgctcctgcg tttgagaaat ccagctttgt tcagagtcta gagaggaatt ttgctcctgg
     7921 tttgcttgga caggaacact tgaattccgg cgatcatata tttgttgcgg atctgcatag
     7981 gcagagaacg attcatcatc cagctgctct ttggacatag acttttcttg ctgaggaacg
     8041 tgctgagtgg aaggtgattc tgatcgtggt actggcgatg gctccggttg tagcgcgtta
     8101 tggagattcg ctggtgcact aggggttgaa gatgggggag atattaggct ctcgtcggga
     8161 ccatgtggtt ctggaccaat accgatatgc ccttgttcat ggacagcagg ggagagaggg
     8221 acaccgaaat cgtcaattac cgaattctct gcatctacgt cgagaatcaa atctaccgcg
     8281 ctgccgtacg cgctaatagg agtatcacgc accatttgcg ccatgccgct gcgctcagca
     8341 atatcaccca cctcatccca aagcgcaagc tcggaaggct caagatgcgg ggaacgccat
     8401 gcacgatctt taggattcat ccgctgggct atctcggata aagcagtgaa aagttccgtg
     8461 gcgtcctcgg ggcgtgcatc cgcttgttta cgtgtgcacc acctgataat ccccgctata
     8521 tcggggtcga ttcccggagc tacttccgta attggaggca tctcaatgtt ggcgttgtgg
     8581 tagagaacct gttgatcgtt gtgtaaaccg gtaaacggta aacgaccgga gaaaatacgg
     8641 tacatcataa cgcccagcgc aaaaatatcc gctggagcac caacacgtcc ttgcgggtct
     8701 aaaatttcag gcgccacata ggcgggggta cccataagaa ccccagagtc atattggtca
     8761 ttgcggcgcg taagaccaaa atctgctaac ttaatgcgcc gctgagtatc taaaagaata
     8821 ttccccggct tcatatcgag gtgaacatac cgatgcgcat gcacctctga aagcccctca
     8881 acaacgggaa gcaaaatttc aagaccttcc cccatagaca gcgcttggcg agagcgaagg
     8941 agctggctga gcgtacaccc ataaacgtac tccaaagcga tatacataat gcgttgcccc
     9001 tgaagatact cagtacctga agacaacaca cctactgtgt gacccccgcc aattttacgc
     9061 agagagcttt cctcacgatg gaatttttgc ctgttctccg cttgttcggc aagttcgggc
     9121 gtaagcactt taatagctac gggattattc gaccacaagt cagaagcgta atagacttca
     9181 ctcatgcctc cgcgggctat cattcgtccc atgaggtagt gcttttcgag cacttgacca
     9241 gttaaccgca gcggctgctt ataattcgtc tggggagcag gaccgggcac agaggaaccg
     9301 gaattaggct gtggagtatg actcatagtg ataaaaattt taggcgatgc atttgaatga
     9361 tgcgacccta ttcgtcatgt cggaacctaa ccctcagcag attttcagga aaggtgtata
     9421 cctatgattt agtcgtaggc tagatgagca cgctacttgc aacacaccag cttgcggcac
     9481 ggaataagtg gtaattgatt aggctctctg gcactcttaa agggtgacta acgaaaatat
     9541 tgctcagacc tttgcccttg taggcgagtg ggtcactatt ccagagatcg ctgagatcct
     9601 cgatctgaag atcactcgca tacataacct tctttctgac gggtctttga tagccttgcg
     9661 cgatcccgaa accaacgtgc gtaaagtccc cgcactcttt ttgaacggga accgcgtctt
     9721 ggaatcttta aagggaactc tagtcgtact caaagactca gggttcagcg atgaagaagc
     9781 aatcgtctgg ctatacacgg atgatgactc tcttcctggg cgccctattg atgctttgaa
     9841 agacggacgc aagacagaga tccgccgtcg cgcacaggcg cttgcctggt aaaacaaaac
     9901 taagaagagt ttttatcaag atcgagttcc aacggtaccc gaaaaatata tagttatgcg
     9961 gcgcatctaa cagcttggac gcgccgcatc accattctct ctaagcttta cggtgcagcg
    10021 ccttagccgc tatcgcgctg agcgcgcagc gtatcggctc ggataccggc agcgcatgaa
    10081 gagcagtatc tacagcttct gacttctgag cgataagctc ttcgacatgc tctagagccc
    10141 cagagcctat cataagctct cggattttag agatttgctg gttcgtgagt tccgggttcc
    10201 ctaaggcacc ttcaagcatc ctgcggtctt cagcagagat attttgtgct gttagcgcta
    10261 tgagaacggt gcgttttccc tcacgaatat catctccggc gggtttgcct gtggcgctag
    10321 gttctccaaa gacaccaagt tcatcatcac gaagctgaaa tccttctccc agcggaagtc
    10381 cgaaagcacg atatttccca agaatcgggt ggtcttgatg cgcgattccg gtgagtgcta
    10441 aagcccctcc taagacgagt gggtgctcac aggagtactt tgcggatttg tattgaataa
    10501 cacggtgagc acgagcgagg gcgttctcag gagtctctgc tggaataact tcggaaagca
    10561 catcaaggta ttggccagcc ataacttcgg tacgcatagt atcgaagata tttcgcgctt
    10621 cggtgccgga taaagcacct tctccgatgg atgagaacat ctgttccgac cacgaaaggc
    10681 acagatcacc cgcgatgatt ccaccggtta gtccgtagtt gaaagtatcg cccacccatg
    10741 agttctggat gtgctgcgtt tcaaactttt tatgtactga gggctttccg cggcgtgtat
    10801 cagagcgatc gataatatcg tcgtgaataa gagccgctga ttgaaagagc tcaagggcag
    10861 cccctgctcg aataataggg gtaggagccg atccttcgag tatggagtct cctccagcac
    10921 ctcgccatcc ccaatagccc agaagagccc ggagacgttt ccccccggaa gagagcgact
    10981 cgatagcttc aagaaggggc agtgcatcgt gagatatagc ggtcagcaga gtgcgttgtt
    11041 gtgcgaaaaa ttctgacata gtagcttcga ctgcgcgtag gtaagcttct tgctcagact
    11101 taacgccgtc gctgagattt tcaggtttcg gctgttctgc catgtttgtg ttccttaggg
    11161 gagtgcgcgc gaatactcct ctagagtaaa gcaccggtcg atatttgcga atattataac
    11221 cttcctaagg tcagaggttt ctataatata gaatacaagt actaattata gaatatatat
    11281 gctattatat tgtgaattgg gaaggagggg tatgaaccag cagcaggggc gcgttgttat
    11341 gcatcttgat atggacgctt ttttcgttaa tgtggagctt ctggagagcc ccgaattaca
    11401 gggtgcacct atcatcgttg ctccacaagg gcctcgcgcc gtggtgtgtt cttcctcgta
    11461 tgaggctcgc atatatggag ttcgttctgg tatgcccctt tcacgagctc tttctctatg
    11521 tcctgctgct gtggtcatgc ctcttcgcgg taactatagg tattattcgc aggctgttat
    11581 ggatattttg cgtacagaaa gcccgttggt agaacaggta agcgtggacg aagcttttgt
    11641 ggatctcacg ggtgcagtta tccatggaac gagtcctgta gatatcgctc agcgtgtgcg
    11701 ttcacgaatt gcggaggaac ttcatctacc aagctcggca gggatttccg tcaataaact
    11761 tattgccaag atggcttcga ccggtagtaa acctaacggg ctatgggtgg ttcctcccgc
    11821 aaaagtccgt gagtttttag atccacttcc tgtctcaaag ctctggggtg tagggtctaa
    11881 aagtgctgca gccctcggta aatacggtat tacaacaatt gctggtttac gcgaactcga
    11941 cataagctgg ctgcgtgcac ggttcggacg agctgctgga gaacaccttt gggctacatc
    12001 tcgtgggctc gatagccgtg atgttgtgcc ctatcgtgaa gagaaaagta taggcgctga
    12061 gcacacattc gggactgata ctacgtcggg gtatgagatt acagatgctt tgcgctcgct
    12121 ttcgtttaaa gtgggtatac gtttgcgccg tgcacgtaag ctggcaggtt ctctcagcct
    12181 caaaattcgg tatgaaggat ttgagactca tacgaaatct gtgccgttgt cagtttcttg
    12241 cgattcaggt atggaaattt atcgggcatc tcatgctgca ctgcgcggga tggggctttt
    12301 ggccttttct gctgagcagt ctcaggagta tgcgacacgc gctattcgcc tcattggtgt
    12361 tcgcgccgaa aaacttgaac gtagtgagct cggagtgcag tatccactct tcgacgatgc
    12421 aatactgtta gatttagagg caggttctaa acatcttgaa gatactgtgg gtgatgatag
    12481 attcaggcct ggtgcttgga atggaatccg caatgctcct gactggagcg cagtggaaca
    12541 tactctcgat agtatccgtc agaagtttac tgatgcagct gtttctagtg cttctgatct
    12601 ttcatatatt cacaagagca gcccagaaaa acagaaaact tcttagggga gcgctctgga
    12661 gtatagggga gtaaaaagtg gagggaatcg aaggatttgg ggtagaaaaa tctgtcctga
    12721 ggtgaatctt cccataaaga gtgtaaacaa gaccatattt ggttagagaa gaaaattttc
    12781 acgcgagcga gcggtaggta tcttaaaaaa ggattgcggg gtagtataaa agcaacggag
    12841 tgttgtaggt ttaggataga cgaataagca ctcatgtcac cggttcgttc aaggagaatg
    12901 aaatggcact ttctgagcgt gaacagaagg ttctcgacca gctcgaagaa ctgatgagcg
    12961 ctgaggatcc acattttgcg tcatcaatgt catcaacggg taatacagct cccgtattta
    13021 gtgcccgaca catggctctc ggcattttag gcgtgttagc tgggttgggt attattatcg
    13081 gtgccgttgc ctcaaagatg atatggctgg gcattattgg atttattatt gctgccggtg
    13141 gtgtttattt ggcgacaaca agtaagaaga ctccggtgga ttcgttctta ggagacaagg
    13201 cgcagggagc aacccaagct cgccaggaag gtgcgggttc ttctgaaaaa tctacaaagc
    13261 agtcgaagtt catgtctcgc ctcgaagagc gttgggacga tcgtaaccgt ggtgaaaact
    13321 aacttttgat gatttaaatt ttactaataa gtttaaagaa acgtccgaga gggcgagtgg
    13381 tttttgataa accactcgcc ctctttggcg cttaaaacta aggaaaagct gtgttctttc
    13441 tgagaaaaat cctcatgagg taggaatagt ggagcaaaat ggagtaaagt ggaggggaag
    13501 atagtttcag gggtagacat gcctaattgg agtcgcgggt attccgcttg tcaggaaagg
    13561 ggtgccgcat gtttcttgga acatatacac cccgcctgga caccaagggg cgcatcatcc
    13621 tgccagcgaa atttcgcgat gagctatcag ctggtctcgt gctaacacgc ggtcaggaac
    13681 gctgcctata cgtgtttcct gtcgccgagt ttgagcgtat ccacgaaaca atgcgaagct
    13741 ctccgcttcc tgggcggcaa gcacgtgact ttatgcgcat gttcctttcg ggagcttctg
    13801 atgaggtgcc tgataagcag ggacgtgtaa cgatcccgcc tgtgctgcgt gagtatgcag
    13861 gtctgtcgca agagctgact gtgattggtt caggaagccg tgcggaaatc tgggactcca
    13921 aagcatggga agaatatatg gcacagacag aagcagaatt tgcgtcgttg gacgaagatc
    13981 ctttcgcccc gattctgtaa tgactatgtc accacacagt tttgttgccc caaacgtaac
    14041 ctgtgatccg ctgtgaacga ccgctagagc tatgggaagg agcatcatga tcgccgagtc
    14101 tcactcactt accggcgtgg ttaccccaac gcacgatgtt tcgacatccc ccaatgctgt
    14161 atctggcgac cctggatatc gggaagggct tttggggcag ctttcacaac gacaggcaca
    14221 ggaacgccat gttccagtta tgctcgatcg ttgcctggag ctgttggaac ccgctatttc
    14281 gcgccaggat gcggttgtca ttgacgggac tttgggcatg gggggccata cagaagcaat
    14341 gcttgaaagg ttctccaacc taacggttat cggcatagac cgtgatgcac aggcgcatgc
    14401 tattgctgcc gaacgtctgg cacgttttgg aaatcgcttc gtgcctgtgc acaccgtata
    14461 tgaccatata gaagatgcga tgtctgcggc gggagtcacc tctgtagatg gcgttcttct
    14521 ggatctaggc gtgtcttcga tgcagctgga cgagcgttcc cgtgggttcg cgtattccta
    14581 tgatgcacct ttggacatgc gcatgaacgg tgatgatgag ctaactgccc gcatcgttgt
    14641 caatgagtac agcgagaatc agctgcgtcg catcatcaaa aactggggtg aagagaaatt
    14701 tgctgcccgt attgcccagc atattgtgga acagcgaaag cacgcaccct tcaccacgac
    14761 tggggaactg gtagctgtca ttcagacggc tgtacccgct gcagcacagc gcaaaggcgg
    14821 tcatccggct aagagaactt tccaggcttt gcgtatcgag gttaatcatg agctagaagc
    14881 tcttgaacgg gcggttccag cggctttgga tgctctgaga ctcggcggtc gttttgtcgc
    14941 tatgagctat cacagccttg aagacaaaat cgtcaaatgt gctttgaccg aggctgctac
    15001 gtcgaaggcc cctaaaggct ttcccgtgga gcttgacgaa catcagccga cgataagagt
    15061 tatcacccgc ggtgcagagc cgcctacaga ggctgaaatc gccgaaaacc cgcgtgcagc
    15121 aagcgctaaa ctgcgtgccg gagaaaaaat caaagtatcc agctgaatct ctaagacagc
    15181 ttaatttaac tctcccggca catctaccta attggcataa caacagatac agacttgaaa
    15241 gagcaggata tgacccctcc gcaacactct ccgagcgtta ccactcccga agcgccgact
    15301 gtaaccggcg tagaggagac gccccgcact gccaatcggc gcaggggaac tcggaacgct
    15361 aatttgcgta ttatccctga gcataaacct gctcaaaaac acccaacgcg ccggggtgta
    15421 ccggggcgga ataaacctgc gtcaaatgtg aaaagccgtg tttctcaaat ccaggttcca
    15481 cgtacttctg taacttctga tacgcacgct cgaattgctc atcgtgcgca gaaccggttg
    15541 tcggaacatg taaccgcata cgctggtccg cgcactggcg gtgctcagca tccgcgtact
    15601 atcggatacc cggcgaaatc tgcataccca gctcgttcga ttgcggctaa gagctcacga
    15661 gtaaaagctc aggctcggga gactcgtcgt gtaccgcttg ccctgtcact ggtacgtccg
    15721 cgaagctgga gtcctgtggc gttggtgggt gtatttgttg ctatcccgtt gaccttggtc
    15781 tttatcttga tgctcaatat cttgatcgca acccgtcaat acgaccttgt ggacttgcgt
    15841 acccaagagc aaacactgac ccaagagaac caagccctgc aacaagaaat tgggtaccaa
    15901 caggccccgc aaaacttggc gaaccgtgca agctcactgg gtatgcatgc gacggatatt
    15961 ccggcaactt tggatatcaa cagcgggcag attaacggca cggctactcc tgtagcgaag
    16021 cctaaagatg atgccccggg cgctcgcaac ctcgtggatg cccccgccgt tcccagtcag
    16081 gggagccgcg cttcgacatc tgcaacaccg agtgcagcac cgtctgcatc ggcagataaa
    16141 cagcagccgg cttcgagtgc gtctgcttca tcgtcagcgt ctgcaaaacc ctcggcatcc
    16201 actaaccctt cagcatctca acgatagtat attggtggag actggaacga actgtttaag
    16261 agtttgaaag gacacctttg agctttcatg agaatgcgcc cgtgccgccc gagcctcaac
    16321 agcttgggcg tcgcgggttt gtagtgggtg ctttggccac tggcggcttg gcagccgtgg
    16381 gtgcacggct tctctatcta caggggtttg atccacagca tactgccgag aaatcgcgtg
    16441 agaaacgcat gcgctctcag attgttccag cggttcgagg tcagattctc gatattaacg
    16501 gagtggtgct tgctcgaagc gtgcagcggt acaacatcat tgcggatcag actattgttg
    16561 cttcgtataa gcgctacgat aatgaccgcg atactaagag tgaaatcact ccagaacagt
    16621 tggtgtatga gctaaccgac attctgcata ccgttgaccc tacgattaca gacgagttta
    16681 tcaagtctaa gcttgacgga gactcaaaat atgccgtcgt gaaatcaaat gtcacccctg
    16741 agatatttcg ccgtattgat gctctaggag ccccgttcct ttatggggaa gccatctctg
    16801 agcgcctgta cccaaacgga cccgtgggcg gctctgttgt gggccgttac cgcattgttg
    16861 atgaggcaac cggtaacgag aacgagacga tcaagaagaa tttatctgta ggtattgagc
    16921 gcgtctttga aaaagatctt gcgggcgtgg acggtcagcg tacctacgaa attagtgccg
    16981 atggtgtgcg tattcctgtt actaaagaag aggcgaccga tgtagaaaat gggaagaacg
    17041 tacgtttgac cattaaccag gacatccagt atttcgcgca gcagattgtc aaagcgcgtg
    17101 tggacgagct caaagcggaa tggggcaccg ttatcgttat ggatgtgcgg gatgcctcga
    17161 ttttggcaat ggccgattct acgatgatgg atcccggcgc cgagaaagtt aagaacgagc
    17221 aggatacaag cccacgcgct atttcccagg ttgttgagcc tggctcaact gagaagattc
    17281 tgactgcatc agctttgatc gaaagcggca ttacgacccc tacctcggcg tatgatgttc
    17341 cggaacgttt ggtgatcaac gggcaaacat tcacggacgc ctttgaccac cccgcacagc
    17401 gccgaacttt ttccggtatt atcaccgatt caatgaatac cggaacggta cttgtcggga
    17461 agaaactccc taaggaagac cgctataact ggctcaaaaa atacggtatg ggggattata
    17521 cgggtattga gctgactggc gaacagcagg ggttagtatc tgattggcat gagtgggacg
    17581 gtcgtcagga atacacagtt ttcttcgggc agggtattgc ccagacccct ctacaaaccg
    17641 ccatgatttt tcaggcactc ggtaataacg gtgtgaaact taaaccgcgc atcgttgacg
    17701 ctttgattga tgccgatggt acggtgcata aacgcgatgt ggaacccggc accaggatgg
    17761 tgagcgaaaa aactgctgaa caatgtcgag aactaatgga gaatgttgta cttcaaagcc
    17821 atgcgaaaac agcctcggtc gaagggtacc gagtcggcgg taagacgggt acagctgaag
    17881 ctcccagcga taaaggcgga tatgacggat acaccacatc ctttataggg cttgcgccta
    17941 tagacaaccc gcagtttctc gtaagcgtta ctctgcagcg ccctcagggc gatgtgcgta
    18001 gtgtgggagc aacaagccag ttctcacaga ttatggagaa agtactgcac acgtataacg
    18061 tgcctaaatc caccacagac ccagtaaaaa ttcctatttt tgcggatgga aaatctaacg
    18121 ggtaagtcac atgcggtcac ccgactgtgc agaacttatt acaataggaa cgtaccttgg
    18181 cgttgatcga ggacgataac aataaaaatc tcggcggcaa gaaatgcgta tgaccgtcag
    18241 gaaagaagga taatggacag cgaaacgcgc ttggctcaag acgctcgtcg caccccgcac
    18301 ttgggcggcg atgcgcagag tctgcgacct cagaattcac gagggagcac ggttactgag
    18361 ctcgtggagc atctagagac cttaggcgcg catcctgttc tagaacatca aggctctgaa
    18421 gaagatgtgc gagggatcag catggattct cgcgcggttc gtcctgcaga cctatatgtt
    18481 gctcttccag gcgcgaaagc tcatggtgca caattcgcgc aaaaagcact agaggcccag
    18541 gctcacgcta tcctcacgga tactgcaggc gctcggatga ttcgggaggc aaatctttct
    18601 ttagatgggt gctccctgct ggtctgtgac tctttacgtc ctgttatagg atcactcgcc
    18661 gctttgatct atgggtcaca agattacaag ggtctgaatc gctacgctgt cacaggaacc
    18721 aatggaaaaa cgacgactac ttacatgctg gagtcggtat tccgaactgc tctcaaggct
    18781 aagaccggtc ttatcggtac tatccaaatt ctcgttgatg gtgtgagcgt tccttcagct
    18841 ctaaccaccc cagagtctgt tcacgttcat tcgctccttg cgattatggg ggagcgcggt
    18901 gtgtctcatg cagcaatgga agtttcctcg catgctatcg actatcaccg tgtggatggt
    18961 gtagtttata aggtttctgg gtttacaaac ctcacccagg atcatttaga tttgcacggc
    19021 accatgcaga attattttga ttctaaagca cagcttttta cgcccgagcg gactgagcgc
    19081 gctgtcatca ctgccgatga cgagtggggc gagaagatgc ttcgccacgc ccagattcag
    19141 ctgggtaccg gtaatgttgt tcggcttgtt actgagcacg gcgcgggtct agccgaggtc
    19201 ccggctgagt tcggttcgct cgattgggcg gtaaccaacg ttgaacgtga tggtttaggg
    19261 catcgtttta cgttggctaa cggcgcggga gacactattc cctgttgtac ccatcttccg
    19321 gcagatttca atgtctcaaa cgccgcgctc gccgcgctga tggtatatat tggtgcttct
    19381 gaggaagaac gcattatcct acgacctgcc ctagctgatg gcacggcact aacccctata
    19441 gtgcccgggc gtatgcagct gatttctctg gcaccgcata ctattgtcga ttttgcccac
    19501 aaccctgacg ggctcactcg ggcgcttgaa gccatggacc gaccaggtgg tgggcgagtc
    19561 attattgttt tcggggcaac aggcgaacgc gatcatctca aacgtcccct aatgggagaa
    19621 attgctgcgc agcacgccga tattgtgatt gtgaccgatg acgatccgca cggtgaagat
    19681 cccgccccaa ttcgcgaggc tgttgttgcc ggggctgaac gagcgattgc cggaggtgcg
    19741 cgggcatccc aaatccttaa tcttgctcca cgagaagtag cgattgcgcg ggcaattgag
    19801 ttcgcagatg cgagagatgc tattcttatc gccggtcgtg gacatgaaac ggcgcaggat
    19861 gttgccggta ccgatgtgca acttgacgac cgcgtggaga ccgcgaaagc gcttgtctcc
    19921 aacgacttcg aaattcttcc ggattatcga cgcatgcttg aagaagcata aggagcatag
    19981 atgattaagc tttccgccgc cgaaattatt acggcaacag gcggctcacc gctcggctta
    20041 gccgggcgtg agagcgagct aggtgctacc ttcgcgacca ccgattcgcg tgaggttata
    20101 ccaggcacac tatttgttgc taagccaggt gaggtgaccg acggacacaa ctttgtgtcg
    20161 ggagccttcg acaaaggcgc tgtcatagcg cttgttgaac gccccgttaa agatgagcgg
    20221 ggtgttttgt accccagcat ccaggttgat gatgtggttc tcgccatggg taagatcgca
    20281 cagtatgctg ttgaaaagat gcggtctcta ggcgatctta cggttatcgg tattaccggt
    20341 tctgcgggga agaccaccac aaaagattta ttagcagcga ccctaagttc tcagggcgaa
    20401 actatagccc ctgtaggttc gtacaacggc gaagttggcg tacctttgac tgtattccgc
    20461 gctgacgaaa gtactcgcta ccttgtgatt gagatgggtg ccgatcatgt ggggaatatc
    20521 gaatacctgg caaatattgt gcaccctgac catggtgtga ttcttaaagt tggcaccgca
    20581 catgctggcg agtttggcgg ggtcgacaac atcgaacgta ctaaagggga gcttgccgaa
    20641 ggtattcgta ctggcggaac cttgatcctc aatgctgatg atgagcgtgt tgcacgcatg
    20701 tcagctcgcg caagtgtgcc ggtaacctac tttggggtgg gggagaaacc acagtacgaa
    20761 cgctatgctg ccgctttggg gctgcatact aatgatgctg gttgtccgga atttactctt
    20821 cgccttcccg acgccagcga atatgagatt tcctccaaac tcattggtga gcatcatgta
    20881 tgcaatattc tggcggctgc tacggtagcc tataacgctg gtgttcctgg aggcgctatt
    20941 gcgcatgccc tcaataacac cggtgcgctg tcgaaatgga ggatggctcg cacagaccgc
    21001 gcagacggcg tgactgtcat caacgatgcc tataatgcta atcccgagtc aatgacagct
    21061 gctttacgca ctttggccca actgggacga ggcgcgaagc cacgacggac atgggcagtt
    21121 ttgggggcca tgctcgaact ggg
//
