LOCUS       NZ_KV804811            22245 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Rothia sp. HMSC065G12 Scaffold56, whole genome shotgun sequence.
ACCESSION   NZ_KV804811
VERSION     NZ_KV804811.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Rothia sp. HMSC065G12
  ORGANISM  Rothia sp. HMSC065G12
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Micrococcaceae; Rothia.
REFERENCE   1  (bases 1 to 106207)
  AUTHORS   Mitreva,M., Pepin,K.H., Mihindukulasuriya,K.A., Fulton,R.,
            Fronick,C., O'Laughlin,M., Miner,T., Herter,B., Rosa,B.A.,
            Cordes,M., Tomlinson,C., Wollam,A., Palsikar,V.B., Mardis,E.R. and
            Wilson,R.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2016) McDonnell Genome Institute, Washington
            University School of Medicine, 4444 Forest Park, St. Louis, MO
            63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Velvet v. 1.1.06
            Genome Coverage                   :: 144x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001811455.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 12:58:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,178
            CDSs (total)                      :: 2,120
            Genes (coding)                    :: 2,076
            CDSs (with protein)               :: 2,076
            Genes (RNA)                       :: 58
            rRNAs                             :: 3, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 44
            CDSs (without protein)            :: 44
            Pseudo Genes (ambiguous residues) :: 0 of 44
            Pseudo Genes (frameshifted)       :: 4 of 44
            Pseudo Genes (incomplete)         :: 39 of 44
            Pseudo Genes (internal stop)      :: 2 of 44
            Pseudo Genes (multiple problems)  :: 1 of 44
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:45:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 72334
            Orig. end                         :: 94579
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KV804811.1.
            The WUSC is a large strain collection isolated from clinical
            samples. Each sample is associated with metadata, including source,
            isolation site, 16s rRNA, metabolic, and other phenotypic
            information. The goal is to sample an adequate number of important,
            yet minor species, further adding to the catelogue of sequenced
            bacterial genomes and improving the diversity of the genomes
            available to the public. WGS will be preformed on approximely 550
            isolates. Samples were selected based on RDP analysis at the genus
            level. This is a reference genomes for the Human Microbiome Project
            and the work was funded by the National Institutes of Health (NIH)
            grant U54 HG004968.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22245
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..22245
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22245
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12245](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12245)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(181..699)
                     /locus_tag="HMPREF2804_RS02835"
                     /old_locus_tag="HMPREF2804_02840"
     CDS             complement(181..699)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013397916.1"
                     /locus_tag="HMPREF2804_RS02835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02840"
                     /product="hypothetical protein"
                     /protein_id="WP_004005649.1"
                     /transl_table=11
                     /translation="MGLKDFLQSRRDDAELGRGLWRRAHDRFIRGIDRFHQVLERLADT
                     EMIELIVPDANTLADLIPRVRAVAMEAQRIAPSDGMDIPASPEGTFSDLHRALSKAGNA
                     VALCAEALAMARCFGECSVQCHRKITVERRVQSVVEHVENAERLIARARDEKAAQARNE
                     NLSLQTTSV"
     gene            complement(864..1874)
                     /locus_tag="HMPREF2804_RS02840"
                     /old_locus_tag="HMPREF2804_02845"
     CDS             complement(864..1874)
                     /NRPS_PKS="Domain: PKS_ER (14-333). E-value: 2e-59. Score:
                     193.2. Matches aSDomain:
                     nrpspksdomains_HMPREF2804_RS02840_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005504431.1"
                     /locus_tag="HMPREF2804_RS02840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02845"
                     /product="NAD(P)H-quinone oxidoreductase"
                     /protein_id="WP_070449337.1"
                     /sec_met_domain="ADH_N (E-value: 3.3e-11, bitscore: 35.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-24, bitscore:
                     79.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAIVEKEHGDPEVLTLSEVPIPAPAPGQVLVRVHAAGLNRADSL
                     QRRGHYPPPAGASSVYGLEIAGVVEAVGEGVDPALVGERVMALLAGGGYAEYAAVDVRH
                     TLPVPKGMSMVEAACIPEVAATVYSNLVLLCGMSLDPAQNKPAEDEQTSLLVHGGTGGV
                     GMHAIQLARAAGVRVFATVGDDEKAQVVRALGAHPINYRTESFRQVIQRESAGHGVNYI
                     LDVVGAKYLEDNLRSLADGGHLATIAVQGGRRAELDLGLMLTKRLSVHGTSLRSRSADE
                     KAKIMAGVHENVLPLLERGVLSANLDREFPWWQASQAHEYFDAGQHRGKVVLRVM"
     aSDomain        complement(876..1832)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HMPREF2804_RS02840_PKS_ER.1"
                     /evalue="2.00E-59"
                     /label="HMPREF2804_RS02840_PKS_ER.1"
                     /locus_tag="HMPREF2804_RS02840"
                     /protein_end="333"
                     /protein_start="14"
                     /score="193.2"
                     /tool="antismash"
                     /translation="LTLSEVPIPAPAPGQVLVRVHAAGLNRADSLQRRGHYPPPAGASS
                     VYGLEIAGVVEAVGEGVDPALVGERVMALLAGGGYAEYAAVDVRHTLPVPKGMSMVEAA
                     CIPEVAATVYSNLVLLCGMSLDPAQNKPAEDEQTSLLVHGGTGGVGMHAIQLARAAGVR
                     VFATVGDDEKAQVVRALGAHPINYRTESFRQVIQRESAGHGVNYILDVVGAKYLEDNLR
                     SLADGGHLATIAVQGGRRAELDLGLMLTKRLSVHGTSLRSRSADEKAKIMAGVHENVLP
                     LLERGVLSANLDREFPWWQASQAHEYFDAGQHRGKVVL"
     CDS_motif       complement(1290..1313)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HMPREF2804_RS02840_0004"
                     /evalue="3.90E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="HMPREF2804_RS02840"
                     /protein_end="195"
                     /protein_start="187"
                     /score="-1.8"
                     /tool="antismash"
                     /translation="AQVVRALG"
     CDS_motif       complement(1305..1352)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HMPREF2804_RS02840_0003"
                     /evalue="1.00E-04"
                     /label="PKSI-ER_m6"
                     /locus_tag="HMPREF2804_RS02840"
                     /protein_end="190"
                     /protein_start="174"
                     /score="15.1"
                     /tool="antismash"
                     /translation="GVRVFATVGDDEKAQV"
     CDS_motif       complement(1362..1418)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HMPREF2804_RS02840_0002"
                     /evalue="8.60E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="HMPREF2804_RS02840"
                     /protein_end="171"
                     /protein_start="152"
                     /score="21.4"
                     /tool="antismash"
                     /translation="SLLVHGGTGGVGMHAIQLA"
     CDS_motif       complement(1656..1691)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HMPREF2804_RS02840_0001"
                     /evalue="5.30E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="HMPREF2804_RS02840"
                     /protein_end="73"
                     /protein_start="61"
                     /score="9.9"
                     /tool="antismash"
                     /translation="GLEIAGVVEAVG"
     tRNA            2024..2111
                     /anticodon=(pos:74392..74394,aa:Ser,seq:tga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HMPREF2804_RS02845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HMPREF2804_02850"
                     /product="tRNA-Ser"
     gene            2024..2111
                     /locus_tag="HMPREF2804_RS02845"
                     /old_locus_tag="HMPREF2804_02850"
     gene            complement(2182..2514)
                     /locus_tag="HMPREF2804_RS02850"
                     /old_locus_tag="HMPREF2804_02855"
     CDS             complement(2182..2514)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013397918.1"
                     /locus_tag="HMPREF2804_RS02850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02855"
                     /product="hypothetical protein"
                     /protein_id="WP_070627204.1"
                     /transl_table=11
                     /translation="MSENYNFQPQQNPQGGYPQQGYQQPYQPTIDPEAVKAEKNAKIYS
                     ITSLVLGALGIGIFTIGFGIVAVVSCIRGLIANKGKNAGYTAMALIGGILGAFDIVLGF
                     LSRLVS"
     misc_feature    complement(2628..2645)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.15"
                     /tool="antismash"
     misc_feature    2676..2692
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.49"
                     /tool="antismash"
     gene            complement(2747..3316)
                     /locus_tag="HMPREF2804_RS02855"
                     /old_locus_tag="HMPREF2804_02860"
     CDS             complement(2747..3316)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013397919.1"
                     /locus_tag="HMPREF2804_RS02855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02860"
                     /product="cell division protein FtsK"
                     /protein_id="WP_070627206.1"
                     /transl_table=11
                     /translation="MSEHHAGEQPSQSQNPHQGEDAYEKTRPLSDSLPEYTKLYQSQQQ
                     PAPRQQDYQQTVPQQHYHQSAPQQYYQQPAPQQYYQQPVYVQPVPMMAVVPKTPQQIAG
                     EQAAQTSLALGIVGLVLALFWVTSVIPLGLGIWGAVKGAQASRAGVLAGGGLATSWIAL
                     SLGAIETLFFFIPMVAFVIAAIASTR"
     tRNA            3544..3635
                     /anticodon=(pos:75912..75914,aa:Ser,seq:gct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HMPREF2804_RS02860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HMPREF2804_02865"
                     /product="tRNA-Ser"
     gene            3544..3635
                     /locus_tag="HMPREF2804_RS02860"
                     /old_locus_tag="HMPREF2804_02865"
     gene            complement(3825..4346)
                     /locus_tag="HMPREF2804_RS02865"
                     /old_locus_tag="HMPREF2804_02870"
     CDS             complement(3825..4346)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004005656.1"
                     /locus_tag="HMPREF2804_RS02865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02870"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_004005656.1"
                     /transl_table=11
                     /translation="MVENSLRDVKRLIIMRHAEADWGMDDFDRPLTKRGHRQAADAGSW
                     LKQKGYIPEQLMSSAALRTRQTTTWISDALGEQAPTPHLDEGLYEVPASRVLARINGVS
                     ESVRTLMVVSHLPAVQDVTLQLASPDSDYNSLMDASYGFSPSSVAVFEVPGEWALLDGA
                     DARLIDFMSF"
     gene            complement(4471..5238)
                     /locus_tag="HMPREF2804_RS02870"
                     /old_locus_tag="HMPREF2804_02875"
     CDS             complement(4471..5238)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005507582.1"
                     /locus_tag="HMPREF2804_RS02870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02875"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_004005657.1"
                     /transl_table=11
                     /translation="MSGAVPGYVHISQRGRAAKRQVPQQNRTQGSAATLRPMTFSSGDQ
                     QGTQKAGAQENEARGFVLYVGLNEELAAANGTSLVRIVQDLRTYAHHLAPEAESYAAVA
                     LAPVHAEGSDLEVVRNALGDPTAVFYQAELHKQAREAEQPATPSSNGVLIDLARREVFL
                     DGEQLMLTFKEFELLAHLVENSTRTVGRDELLESLWSAGDEHPHERTIDVHIRRLRSKL
                     GRLSGTVRTVRGQGYRFFEHPEVVVWAAPEYSI"
     gene            complement(5781..6419)
                     /gene="upp"
                     /locus_tag="HMPREF2804_RS02875"
                     /old_locus_tag="HMPREF2804_02880"
     CDS             complement(5781..6419)
                     /EC_number="2.4.2.9"
                     /GO_function="GO:0004845 - uracil phosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="upp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006887073.1"
                     /locus_tag="HMPREF2804_RS02875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02880"
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="WP_070449326.1"
                     /transl_table=11
                     /translation="MRIKILDHPLVAHKISVLRDKNTPSPTFRQLVDELVTLLAYEATR
                     EIRVEQRPIETPVARTMGTVIANPKPLVVPILRAGLGMLEGMTRLVPTAEVGFLGMARN
                     EETLDIVTYAERLPEDLTGRQVYLLDPMLATGGTLIEAIKFLRERGAESITCVCLIAAP
                     EGIAALEKGVEGLRNVDLFLAAKDERLNEKAYIVPGLGDAGDRLYGLAQ"
     misc_feature    6888..6907
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 21.6"
                     /tool="antismash"
     misc_feature    complement(7689..7702)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    7691..7707
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 21.52"
                     /tool="antismash"
     gene            complement(7706..9427)
                     /locus_tag="HMPREF2804_RS02880"
                     /old_locus_tag="HMPREF2804_02885"
     CDS             complement(7706..9427)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="HMPREF2804_RS02880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02885"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_070535293.1"
                     /transl_table=11
                     /translation="MKPHKNIGNRLVGIFSYASISNSVIFLAIISSIIATIAPIIQPYL
                     LNQLLGGGDRPAISTYGFALLVLLIVGAIARAVEQYTFGIAGENIAANFRRQLIKHLLS
                     GHIIKVEQWSKGEIASRLGADITQVKSAFSDGYFRLPQSIILVIGSAICMACIDIKLFT
                     VVFILLIIIFTAFLLSSRKLNGYSKNYHDEVGLFSERIVQFIEGFRILKVSNSLKQFGN
                     YLSISIRGIEGRGRVLAAFDAVLGSISNLTLQLSLLVVLAYGGLRVIGNTITMEGLISF
                     ILYLSVATSAFGEAFGCISFIQKGEGAFKRVQPIFDIPLEKTNGVKKTLENQSIIFKDI
                     EFSYGASEKLLKDFTLNLEHGSTTVIVGPSGAGKSTVLAMLLRIITPQKGVISIGGQDI
                     SCMDLYALRDLFAYVDQDSMVIPGTVRENLLIGNPKVKDVDLIRALHDVGLDTRFKENG
                     LDTVLGEAGAQLSGGQRQRLVIARAIASNKPILLLDEPTSALDGESEDRIFSSELLQGT
                     KTKLIVSHRVSIAQHADNVVVMKSGAIEAFGKHAELLKISNYYRAMWEREDKINLD"
     gene            complement(9492..9974)
                     /locus_tag="HMPREF2804_RS10695"
     CDS             complement(9492..9974)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="HMPREF2804_RS10695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_168162152.1"
                     /sec_met_domain="Abi (E-value: 1.1e-09, bitscore: 31.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHCIWTLKAPKNLWRINAPEFFYYDGPTLALALLDIPDIKQKHIS
                     KSNVSSFIMGAATGITFAQVSRWVAGLPPNIDTKRLKDLNLISVAIAEEIIWRGNIDGS
                     FDRVTSIAGFGVLHYPLGREKAVLHMLLFAFLATKIREKYGLMSSIVFHVFYNFTR"
     gene            complement(10001..10834)
                     /locus_tag="HMPREF2804_RS02885"
                     /old_locus_tag="HMPREF2804_02890"
     CDS             complement(10001..10834)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009884133.1"
                     /locus_tag="HMPREF2804_RS02885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02890"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_070535291.1"
                     /sec_met_domain="PF00881 (E-value: 2.1e-20, bitscore: 66.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDKNFLQKHGSNIRELIHGGPVPGINDPAENYLQASKLTREGLA
                     WETPMIPTLMESEDLQRTTMRSARRYDSRVFTSFKEVTEISKALKRALSQRRSTQQFKE
                     KSLKLSVLASVLENSYGAYDVHGGQTRRNTPSGGALYPLDIFIVTRDVTGLTSENLYFF
                     DPFRHGLTDMAQGIDLDSFRDALLLPDAIKEASAFIIISASIWRCRFKYAQRAYRFCCI
                     ESGHLAQNLLTVATDLGLGTRIFGGFIDNEIVSFLPDINGIDDVPMYIIALGERA"
     gene            complement(10845..12245)
                     /locus_tag="HMPREF2804_RS02890"
                     /old_locus_tag="HMPREF2804_02895"
     CDS             complement(10845..12245)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="HMPREF2804_RS02890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02895"
                     /product="YcaO-like family protein"
                     /protein_id="WP_070535289.1"
                     /sec_met_domain="YcaO (E-value: 2.6e-58, bitscore: 190.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.2e-86, bitscore:
                     282.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTQRSKLTYTEFLDYLKEWDKPVNLTKLGLEFSRKVTSSRYGVV
                     VRAVDRTHDWDDAYTFSIGSTAAESKFTLGTTTNKYNGGGWIDETQTYLAAVGETIERY
                     CGAYPHFDLQRQASYRELINDGFQAIDPNDISLFDPTQFEDSRFEFREFNEDSVIHWVR
                     GFDLTNSTEIYYPAALLLLTNFAEVEGKPIGYSTSSGLASHSTPLDAIISGLYEQAERD
                     AFCIAWYGGLTFPRIDPYSDKELRYFWKDFIEPSGIDVELIDVSKVNEIPTVVAVSVNR
                     TTDVAPIAFGASSAASLLDACKSASVESLQTRNWVKANQRDGISNINLTDDLYETIKDF
                     EDHIMFYIPREAADKARFFYEGELQPLNNAHDLKKSNSKIIQLKELIEKARQQNGRVLT
                     FDLTTPDISQVGGHVFKTIIHGFQQLDCGYGRRFLGGSRLRNRPVEMGFKNTELTITDF
                     NQWPHPFP"
     gene            complement(12242..13225)
                     /locus_tag="HMPREF2804_RS02895"
                     /old_locus_tag="HMPREF2804_02900"
     CDS             complement(12242..13225)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF2804_RS02895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF2804_02900"
                     /product="hypothetical protein"
                     /protein_id="WP_070535287.1"
                     /transl_table=11
                     /translation="MKYCLNTAHTIQYNKDNIWINGERSLKKIKDHTLLDFILQMCADG
                     GIIDSEIVEDFEQRASLERALVLLEDAGILVQVDKAEPWPNIVLNLYNYSEGTCEISEI
                     KSALDSATIIIFAPNEKDFAYQLKNDIEHEITGTGMNVHVCNELESIGALSEKSLILVV
                     GSADGDQLFDHVNETALKEKWRVWLPISPPMGTSSQIGPWIYPHSSACYRCYRLRKTSV
                     SWSDNYVAPDLDTIARPVTRSLYADDSLATTILSAQIARSSIMHVGLNGYIGQAPHGYT
                     THFSNSMDGFVAENHYILRVPRCEECSPTAHTGYPQIWFHGEMGQK"
     gene            complement(13236..13913)
                     /locus_tag="HMPREF2804_RS02900"
                     /old_locus_tag="HMPREF2804_02905"
     CDS             complement(13236..13913)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF2804_RS02900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF2804_02905"
                     /product="hypothetical protein"
                     /protein_id="WP_070535285.1"
                     /transl_table=11
                     /translation="MSANYLGTRPFVNRLIAGFPEFQTTRQIIDLFTMNWEEVGQKIES
                     TTWEGIDELVVLRPFISYEQCNQAYAQWINHVESCLPPQHKTIYMGTLPEDWTAYIANA
                     QRFGYFLVMEPHEKFRATTTRSLCNGLSQINIGEVSDVYLDFELDPKELKDIAGSVFEY
                     IELPPTEYVETLIKFAEKDSVERLASFQSLFSGPVSNKFFCQNTVQEIDEWVGNLKGLM
                     KRK"
     gene            complement(13903..14616)
                     /locus_tag="HMPREF2804_RS02905"
                     /old_locus_tag="HMPREF2804_02910"
     CDS             complement(13903..14616)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="HMPREF2804_RS02905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02910"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_070535283.1"
                     /transl_table=11
                     /translation="MNKAQRVTSASDWYVNESLRHIARGHDKPYDLRYSKMVACEVSRM
                     KPFRLIDIGCGYGELFKALYYRDIPVTYIGFDPDKKCIESLQELHSKQCKAHLGDSESA
                     IDYVQNTHVDVVTSVLSLGLWNDPVGDLIKVAHALPPGGQIIAVDLLKLCEIPYPLNAA
                     PLSRYKIDQYNSSLAESDINILCEDLSATCESEIKWFVDIGLEPQEIDYNSIQNQKPFT
                     TLFFIRITRKELNVG"
     gene            complement(14609..15103)
                     /locus_tag="HMPREF2804_RS02910"
                     /old_locus_tag="HMPREF2804_02915"
     CDS             complement(14609..15103)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013397749.1"
                     /locus_tag="HMPREF2804_RS02910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02915"
                     /product="hypothetical protein"
                     /protein_id="WP_070535281.1"
                     /transl_table=11
                     /translation="MLIATIVTEVMFWVCLVLGSIFRYTLKMPKLGITLLAATPLIDMM
                     LLAFSFITLRQTSTAEFMHGFAAFYIAFSIVFGRSIIQTFDRKFSGATPAVLAANSAQQ
                     LKKCVVACLIAVVLLVAEILVTGIRGSFWLVYWVIAVIFTPLMWWGVEKWYAHVREKNY
                     E"
     gene            complement(15201..15341)
                     /locus_tag="HMPREF2804_RS11440"
     CDS             complement(15201..15341)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04218.1"
                     /locus_tag="HMPREF2804_RS11440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantazolicin family TOMM peptide"
                     /protein_id="WP_141745260.1"
                     /transl_table=11
                     /translation="MSDLLAALPKHFDTTVENVQTAGKAFEPTAARCTCSTVPCCCCWS
                     N"
     gene            15562..16056
                     /locus_tag="HMPREF2804_RS02915"
                     /old_locus_tag="HMPREF2804_02920"
     CDS             15562..16056
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004005662.1"
                     /locus_tag="HMPREF2804_RS02915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02920"
                     /product="hypothetical protein"
                     /protein_id="WP_083308335.1"
                     /transl_table=11
                     /translation="MPSVVWGLWVCRVSYREILPEKLMRVNNRGRKQVLHYWQIDSSYF
                     TLLGDENGLFELTDTAGVVYRFKPHIEPCRYLGSQVAFRLDYGYWADPNNTQDAEILVQ
                     YIREKLWVQRLLEVPTVSGLALDGVGLEYRPAGGPGFGPEFRSRQSVSGDFTWATNFVL
                     T"
     tRNA            complement(16135..16221)
                     /anticodon=(pos:complement(88519..88521),aa:Ser,seq:cga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HMPREF2804_RS02920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HMPREF2804_02925"
                     /product="tRNA-Ser"
     gene            complement(16135..16221)
                     /locus_tag="HMPREF2804_RS02920"
                     /old_locus_tag="HMPREF2804_02925"
     gene            complement(16448..17059)
                     /locus_tag="HMPREF2804_RS02925"
                     /old_locus_tag="HMPREF2804_02930"
     CDS             complement(16448..17059)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004005669.1"
                     /locus_tag="HMPREF2804_RS02925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02930"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_246824104.1"
                     /transl_table=11
                     /translation="MPDTPNPARRPGRTGKTQRKLFTATMEIMEHRGSAHVSIEEVAQR
                     AGVSKGTVYYNFGSKKTMIDRLLQYGTHLLVESMSEASVAQSDPREGLRKSISTALTYL
                     HEHRGFTRLWVSEVWKGLDAWTDSMVDNRQEILDFIESQVRALRSRYTIDTAQDTRALA
                     LSIFGATFMLAMDREIHGVQRSIEDSTRAVMLVFDGYIRH"
     gene            complement(17108..19672)
                     /locus_tag="HMPREF2804_RS02930"
                     /old_locus_tag="HMPREF2804_02935"
     CDS             complement(17108..19672)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005507584.1"
                     /locus_tag="HMPREF2804_RS02930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02935"
                     /product="YhgE/Pip domain-containing protein"
                     /protein_id="WP_070627212.1"
                     /transl_table=11
                     /translation="MSVVRVALVELKRLTSGVLPVLVLLAMSCIPLLYGSLYLYGNWDA
                     YGNVNGIVGALVVEDEGAKDASGNDLNTGADVKKSLLDAGTFDWKSVETRDKAVQGVSD
                     GTYDFALVIPKDFSARLVSTGSFKPDEKGNTGPINPQAAGLEIITNDANNYVLTNIVTK
                     AGTAVRDSVASKVGDKTANTLLASFTTIHGKMNEAADGADKINANTVKLSDAMTQLADG
                     TGTLNDGAVKLADGSEQLVNGSSRLIEGQNKLADGSSQLADGAGTLNQGAGKVNDGAVK
                     LADGSSTLANGASDTHNGASQLADGSAALANGTGSLKKGANDLAQGAQQVADGTHSLKN
                     ALDQDGVRQLPGTLTAMCQNLNSIDTSAPSGDFGTDLSNTVVSKVAEDTRQKLAPLVES
                     GSISQETADAIVANINSEQTKSAVASANDQALKNHLAQHGQAGSDVLAKLQTLKNDNCV
                     ATGESAAAQKLSTLIDGVDKLDSGATAVAQGAGTLRDGITKLDSGATTLADGSAKLADG
                     TGKVADGASTLNNGASQLAEGTGELKNGTGNLHNGAQQLADGEKEAVDGQNKLHDGATT
                     LQDGSSQLADGTGKLNSSTGQIADGTGQLKDGTGQLSTGLHNGTRQIPNLNEEQQKDVA
                     SVMSSPVDLEHSSLANGRNYGEGMGPFFMCLALWIGGLMLVQTLRPLNNRALASKAPTA
                     RIILGSWLPFGLIGIAQAVLMFAAVKFGLGFQMAHPWLAFFFLCFVATIFTLFIHGVVV
                     FFGSPGKLIALIIMILQLITAGGTMPYETLPHAMRWMHDFFPMGYAVTGMRRLSYGINE
                     SSLMPIMMYLLLWGAAGLVLGYLGTRRDRIWSLKKLIPEITV"
     gene            complement(19675..20604)
                     /locus_tag="HMPREF2804_RS02935"
                     /old_locus_tag="HMPREF2804_02940"
     CDS             complement(19675..20604)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004005672.1"
                     /locus_tag="HMPREF2804_RS02935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02940"
                     /product="hypothetical protein"
                     /protein_id="WP_070627214.1"
                     /transl_table=11
                     /translation="MLTADDIWARGRHKALFGRTSFTVERGEVILIQADSQIERTSLSL
                     GLTGRLKLSGGTLSWDHRSPVSLRHLRSISDIIDSPEVTAPEVHMRVHDYVSEMLSYSL
                     PFFGRPRASHWLEQNDLGELDRLWTEQLTGEQNIRLMSALAAHTRSDLLVFDTPSRHLD
                     HTRMWLPYLQELAENEDDPRAVIAVVPHISESWDGKTAVVGDAHEDLEETPQDARESIR
                     LTVAREETDSSLDDLLGSDHHHDDDHSDPNDRETLESEDPGAKVQTVRSPQEDSAVNAS
                     EVPEALLEDHEEQLEELSNPKNPAEKEQ"
     misc_feature    20719..20734
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.48"
                     /tool="antismash"
     misc_feature    20768..20781
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.52"
                     /tool="antismash"
     misc_feature    20769..20782
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    complement(20887..20902)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 22.93"
                     /tool="antismash"
     gene            complement(20971..21501)
                     /gene="tadA"
                     /locus_tag="HMPREF2804_RS02940"
                     /old_locus_tag="HMPREF2804_02945"
     CDS             complement(20971..21501)
                     /EC_number="3.5.4.33"
                     /GO_function="GO:0008251 - tRNA-specific adenosine
                     deaminase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0002100 - tRNA wobble adenosine to inosine
                     editing [Evidence IEA]"
                     /codon_start=1
                     /gene="tadA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004005673.1"
                     /locus_tag="HMPREF2804_RS02940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2804_02945"
                     /product="tRNA adenosine(34) deaminase TadA"
                     /protein_id="WP_070627216.1"
                     /transl_table=11
                     /translation="MEYNNSGAHAGDGEALSTIATLAEHERWMRLALDEGKRAACAGEI
                     PVGAVVVNAEGEIIGSGHNSREHDHDPTGHAEIHAIRQAAQHLKTWRLEECTLVVTVEP
                     CLMCAGAILMARIPTVVMGAWEEKTGAVGSQYDVLRDRRLGLDVQVYAGVLREECAGLM
                     RTFFEVRRPQQGV"
ORIGIN
        1 aaggttctag ttacctcata tcgtgtgggg ttttacgcgg atttatatgg ttttatgttg
       61 gataattcgc gacgtgaaac cctcaaaaga cactaaaccc ccgaaattat cggggaaatt
      121 atacggtgcc cgtaactaca caactattcg cacatcgccg ctagtttcac gtttatgacg
      181 ttaaaccgag gttgtctgca gagacaggtt ttcattgcgc gcctgtgcag ctttttcatc
      241 acgtgcacgg gcgatcaggc gttccgcatt ctcgacatgc tcaaccacac tctgcacgcg
      301 gcgttctacc gtaatcttgc ggtggcactg cacactgcac tcgccaaagc accgcgccat
      361 cgccagcgcc tcagcgcaga gggctaccgc attaccagct tttgagagcg cccgatgcag
      421 atccgagaac gtgccttcag gggaggcagg aatatccatg ccatcactgg gggcaatacg
      481 ctgcgcttcc atcgcgacgg cacgaacccg cggaataaga tcggcaagag tattcgcatc
      541 cggcacgata agttcgatca tctcggtatc ggcaaggcgt tcaagaacct gatggaaacg
      601 atcaataccg cgaataaacc ggtcgtgcgc acgacgccag agaccacgcc caagttccgc
      661 gtcatcacgc cgtgattgca ggaaatcttt gagtcccata gcccctcctc atgctcagcc
      721 ggtcgtgcgt ctagaaagct ctatatactt agggtaccct aaatctcatt ttggtgacag
      781 gatgtcgtac aaaaaatgtt gatatgggat taagctctcg aaaaattcac gcatttgacc
      841 cggccaaacc ggcacaacac gacttacatc acgcgcaaaa caaccttgcc gcgatgctga
      901 cccgcatcaa aatactcatg agcctgcgac gcctgccacc acgggaattc acgatcaaga
      961 ttcgccgaaa gaacgccgcg ctcaagcaac ggtaacacgt tctcatgcac ccctgccata
     1021 atttttgcct tctcatccgc agaccgtgac cgcaaagacg taccgtgcac cgataagcgc
     1081 ttcgttagca taagacccag atcgagttcc gcgcggcgac cgccctgcac agcaatcgtc
     1141 gccagatgcc caccatcggc taaagaccgc agattatctt ccaggtattt cgcgcctacc
     1201 acatcaagaa tataattcac gccgtgaccg gcactctcac gctgaatcac ctgacgaaaa
     1261 gactccgtgc ggtaattaat cggatgcgcc cccaacgccc gcaccacctg agccttctcg
     1321 tcatcaccga ccgtcgcaaa aacccgcaca ccggcggcgc gcgccagctg aatagcatgc
     1381 atacccacgc ccccagtacc gccatgcacc agaagcgaag tctgctcatc ttccgccggt
     1441 ttattctgcg cgggatcaag actcattccg cacagaagca ccagattcga gtacaccgtc
     1501 gcggcgacct ccgggatgca cgccgcctca accatgctca tacccttagg aacgggcagg
     1561 gtatggcgca catctaccgc cgcatattcg gcgtaaccgc cgccagcaag aagcgccatg
     1621 acgcgctcgc ccaccagagc gggatcaacg ccctcaccca cagcctctac cacgcccgca
     1681 atctcaagac cgtatacgga gcttgccccc gcaggaggcg gataatgccc gcgccgctgc
     1741 agggaatccg cccggttcag cccggcggca tgcacccgca ccaagacctg cccgggtgca
     1801 ggggcaggaa tcggaacctc agagagcgtt agaacctctg gatctccatg ttctttctcg
     1861 acaatggcgc gcatagtagc ctcaacaacc ttcttatctg tatcttcctg caccgagatt
     1921 agcatgtgtt ctcggggcat accgcaatgt tcagatttac agaaaagcat agaacatgag
     1981 ataatcggcg ggtacctttt ccgctcaagg gcggaaaata ccgggatggt tgtccgagcg
     2041 gccgaaggag ctggtcttga aaaccagtag gcggtaaccc cgtctcaagg gttcaaatcc
     2101 cttaccatcc gcacactaaa ccccgcgatg cgcctgattt ttcaggtgta tcgcggggtt
     2161 tttcggcgta gaatctgcag gttacgagac caaccttgag aggaacccca gcacaatatc
     2221 aaaggcaccg aggatacccc cgataagcgc catagcggta tagccagcat tctttccctt
     2281 attagcaata agacccctaa tacaggaaac tacggcaaca atgccaaaac cgatggtaaa
     2341 aatcccaata ccgagagcac ctagaacaag ggaagtaatg gaatagattt ttgcgttttt
     2401 ctctgccttg actgcttcag gatcaattgt aggttggtac ggctgctggt aaccctgctg
     2461 agggtatccg ccctgcgggt tctgctgagg ctgaaagtta tagttttcgg acattactat
     2521 ccttcttggg gtagacgatc ctatcgttgc acataagatc agttttatta tcggctttat
     2581 ttactgtaca gggttaaaga taagtacacg ctttccaaca tgccgtgtta acaaatccgt
     2641 accaacacgg catatacgtt aaagcgccca gatcatgcac aataaagccc cgctatcttc
     2701 ccgacctcgg gattctgcgg ggctgcatct tgtaagctaa cggctgctac cgagtgctgg
     2761 ctatagcggc tatcacgaac gccaccatcg gaataaagaa gaacagagtc tcaatcgccc
     2821 ccagcgacag ggcaatccag ctggtggcaa ggccgcctcc ggcgagaact ccggcacgtg
     2881 aagcctgagc acctttaacc gcgccccaga tccccaaacc cagtggaatc acactcgtga
     2941 cccagaagag ggcgagcacc aaaccaacaa tgcccagcgc taaagaggtt tgtgccgcct
     3001 gctcaccggc aatctgctgc ggggttttgg ggacgaccgc catcatgggc acgggctgca
     3061 catataccgg ctgctgatag tactgttgag gagcaggctg ttggtaatac tgttgagggg
     3121 ccgactggtg atagtgctgc tgaggaacag tttgttgata gtcctgctgt ctaggagcgg
     3181 gctgctgttg gctctgataa agcttagtgt attcgggcag agagtcagag agagggcgag
     3241 ttttctcgta ggcgtcctca ccctgatggg ggttttgcga ctgagacggt tgctctcccg
     3301 cgtgatgctc agacatagct attcctttcg gtgacaagaa gcgacaacta gacctgccca
     3361 ctgtctacct gctgtaggaa atatctgggg aaccgttttc agcctgcgtg aatgggcgtg
     3421 gcaataactc taactatagc gcgttgtttt tcgctcatgg gggaagtttg gtcggcaatt
     3481 ccgaattgac cagcctgctt actcccgata ttcttatagg gatgcactcg tttcgtgcac
     3541 cgtggagacg tgccagagcg gccgaatgga cttcactgct aatgaagggt cggggttgaa
     3601 ctcgaccggg ggttcaaatc cccccgtctc cgccaaagaa tgaaccccca cactgtaaaa
     3661 ggtgcggggg ttcgctgcgt cctaggggcg tagggcatca gattttcgca gtctgtctta
     3721 tgatgcagct ttgtctccgc ctggctaacc ttgccctccc aatcgaaaaa gcggcggttc
     3781 agtaagaaag ggcgagggcg caacgtgccg actgcggata ggatttagaa gctcataaag
     3841 tcgatgaggc gcgcatccgc accgtcaaga agcgcccact cccccggcac ttcaaagacc
     3901 gccacggacg aaggcgagaa gccataggaa gcgtccatca gggaattgta gtcagagtcg
     3961 gggctcgcaa gctgtaaggt cacatcttgt accgcaggca gatgcgacac caccataagc
     4021 gtgcgtacgc tctcagaaac cccgttaatg cgcgccagta cccgggatgc aggaacctcg
     4081 tacagaccct cgtccaggtg cggagtaggt gcctgctcac cgagcgcatc cgaaatccag
     4141 gtggtggtct gccgggtgcg cagcgccgcc gaagacatca gctgctcggg aatatagccc
     4201 ttctgtttga gccaggagcc cgcatccgca gcctgacgat gcccgcgttt agtcagtggg
     4261 cgatcgaaat catccatacc ccagtcggct tcggcatgac gcatgataat caggcgctta
     4321 acgtctcgga gtgagttctc aaccatacct tcatagtaca acgtaggcgc cccgatatgc
     4381 cgggttgccg catgatagcg cgccacaaaa accggcatgc gaaaaccccg cgctcttcag
     4441 aaagaacgcg gggtttcgag cgtaaaaaga ctagatggag tattcggggg ctgcccacac
     4501 cacaacttcg ggatgctcaa agaaccggta cccctgaccg cgcacggtac gcacggttcc
     4561 cgaaagacgc cccaacttcg agcgcagacg ccgaatatgc acatcaatgg tacgttcgtg
     4621 gggatgctcg tccccggcgc tccagagcga ctccaaaagc tcatcgcgcc ccacggtacg
     4681 ggtggagttc tcaaccagat gcgccagaag ctcaaactct ttgaaggtga gcatcaattg
     4741 ttccccatca aggaaaacct cacgacgtgc caaatcgatc agaacgccat tggaactggg
     4801 agttgcgggc tgctcggctt cacgcgcctg cttgtgcagc tcagcctggt agaacacggc
     4861 agtcggatcg ccaagcgcat tgcgcacaac ctcaagatcg ctgccctccg catgaacggg
     4921 agccaaagca acggcggcat aggattcggc ttcaggtgcc agatggtgtg cataggttcg
     4981 caaatcctgc acaatacgca ccagcgatgt gccgttggct gcggcaagtt cttcgttgag
     5041 ccccacatac agcacaaacc cgcgcgcctc gttctcctga gctcctgcct tctgggtgcc
     5101 ctgctgatcc ccggaggaga aggtcatcgg gcgcaaagta gctgcggacc cttgtgtgcg
     5161 gttctgctgc ggtacttggc gctttgcagc acgaccacgc tgggagatgt ggacgtatcc
     5221 aggtactgca cctgacattg ttcaaccttc tctcaagatt tgttgcgtac gggtcccttg
     5281 attctgcatg atgcggaatg ctcaaacacc gcgcggtaag ggcggcgttt cctttgctat
     5341 caatatttct attatttgac tcataaatca agcaacttgg ggtatctgcg acgttctgct
     5401 cgcagcttca caccctcgtg aactttgatt cagtgccggg aaacgacgct gacaagcacc
     5461 gtttctccct catattatac atggagattc ggaaccgata ccccaaaaag ccgcgcgctc
     5521 agagcccctg accgcatacg aaccgggcgc aatttccacg ttctggagcg gaggctccca
     5581 aggataccgt tagctcgtac actactagtg tttttcgccg cactcgcaga tgcatgtgga
     5641 gaaaggggca caccgcagta tgaaggtgac aaggaaccga cgccccgcgt gcaatctcag
     5701 aatcaagtcc caaagcacat gtttgcggca cccgacgtct aagaccgccc gcgcagaatc
     5761 gtcagacccg taaggatgcg ctactgcgcc agcccataga gacggtcgcc tgcatcgccc
     5821 aaaccgggca caatatacgc cttttcgttc aggcgctcat ctttagcggc aaggaacagg
     5881 tcgacattcc gcagaccctc aacgcccttt tcgagagccg caataccttc gggggcagca
     5941 atcagacaga cgcaggtgat ggattcggcg ccacgttcgc gcaggaattt aatagcctca
     6001 atcaaggtgc cgccagtagc gagcatagga tcgagcaggt acacctgacg accggttagg
     6061 tcttcgggca gacgctcagc gtacgtgaca atatcgagag tctcttcgtt acgggccatg
     6121 cccaaaaacc cgacttcggc ggtgggaacc aggcgggtca tgccttcaag catgcccagc
     6181 ccggcgcgca gaatcggcac gaccagaggc ttcgggttag cgataacggt tcccatcgtg
     6241 cgcgccaccg gggtttcgat agggcgctgc tcaacccgaa tctcacgggt ggcctcatag
     6301 gcgagcaggg taacgagttc atcgacgagc tggcggaacg tgggtgaggg agtgttttta
     6361 tcgcggagca cactaatctt gtgcgccacc agcgggtgat caagaatctt aatacgcata
     6421 ctctcagttt actctgcctg ccgcagtggg tggtgcagaa gctaataaac actaatcaag
     6481 gcagcaaagt ctgttggggt cttatggtgt aggttccggc gggttttgct atatacactc
     6541 tatctgggtt tatgggagct tccccaggag cggtcgagca agtagaggag aaaatatggg
     6601 cggcactgtt cgatcttgag agcttctaaa tcttttgtaa cattttacgc ccgacataag
     6661 attactcagc acccattgaa taaactgtaa aatacaagct cctttaaggg cgttctgctt
     6721 tctcaaacct tgtcacagac gtagatccag agttaaaaat ccaaaaattc aaaagaatca
     6781 ctttaataat acccacctac ctccaaagaa cctgagtcag aagtcattca tctgaggtgg
     6841 tcttgaagct ataaaagcaa cccgcgcact accaagaaca cttgaccgta ggaactgatg
     6901 accctaggaa acacgctgaa aagtaccagc cggcaacttg atatggacaa tgacaagctc
     6961 aaccatagct cggcaatgat ccctctaggt ggtttttgct cggtgcgatc aaccccaacc
     7021 cggtataccc tttatctgtt agagcgttcc gaccatccag gctttactaa cagtgcacaa
     7081 ctatcatagt gtgcgcctca gagacagagg ccgtgagcac caggatccca tcaagaattg
     7141 acaaatagcc tggtggttga acccgctttg gcggcattta ccgctaaaca gtcgcagcat
     7201 tggggtggtg cgcaaattgt aggtaggcgc aagaggtacc gtccacgatg attacgctaa
     7261 aaagagttta acttgtgagc tagaggacac gaccgggcgt agaattatca gtgctgcctt
     7321 tccgatgatg gtgataatac aaccttgaag ttttcggcga gggttcttcg gcatggcttt
     7381 tcctcaggta cagcagggtg tggccacaaa ggcttgcttc agagtgagct tgtggagttc
     7441 aatgttcggt gcgttccagg tcaggctacc gttcaattca gggtgatgaa cagtgtctag
     7501 ctcagtcctg tggtatagcg aggaggcaac gatttcttcc gctatgaccc aatggattag
     7561 ttggcttgat tgtaagattc cacagtacca ttagataagg attcatggtt ttacatactg
     7621 gaacataggg ggtgatctat cctaatgaat aatcactata gatataaatc ctccctacca
     7681 ataaatacct ttattataaa ataagctaat ccagatttat tttatcctct cgctcccaca
     7741 ttgcacggta ataattagat atttttaata attcagcatg cttgccaaaa gcttcaatgg
     7801 ctccactttt catcaccacg acgttatccg catgctgtgc tatggatacc ctatgtgaaa
     7861 caataagttt agtttttgtt ccctgtagca gttctgaact aaagattcga tcttctgact
     7921 caccatcaag cgcggatgtt ggctcatcta ggagtagtat aggtttatta ctagcgatag
     7981 cacgggctat aacaagccgc tggcgctgtc caccagagag ctgtgcccct gcctctccaa
     8041 gcaccgtatc caacccattt tctttaaaac gtgtatctaa acctacatca tggagcgctc
     8101 tgattaaatc tacgtcctta acttttggat ttccaataag aagattttca cgcacagtcc
     8161 caggtatgac cattgaatct tgatcgacat atgcaaatag gtcacgcaaa gcatacaaat
     8221 ccatgcacga aatatcctgt cctccaatac tgatgacacc cttttgtgga gtaatgattc
     8281 gtagcaacat ggctaataca gtagattttc cagctcctga tggaccaaca ataacagtag
     8341 tcgacccatg ctccaagtta agagtgaaat cttttaaaag tttctctgac gcaccataac
     8401 taaactcaat atctttaaaa ataattgatt gattctccaa tgttttcttt actccattcg
     8461 ttttctctaa aggaatatcg aaaattggtt gaacacgctt aaacgcacct tcaccttttt
     8521 gaataaaact gatacagcca aatgcttcac caaaagcact tgttgccact gaaaggtaaa
     8581 gaatgaaaga tatcaaacct tccatagtaa tcgtattgcc gataaccctc aaaccaccat
     8641 atgccaatac cacaagcaaa gatagttgta acgtgagatt ggaaatagaa cccaatactg
     8701 catcgaaggc agcaagcaca cgaccacgac cttcaatacc tcgaatggaa atactaagat
     8761 aattaccaaa ttgctttagt gagttggata ctttaagaat gcgaaatcct tcaataaatt
     8821 ggactatacg ttcagaaaat aaacccactt catcgtgata attcttagag taaccattaa
     8881 gtttacgtga agataataaa aaagctgtaa atattattat tagtaaaata aaaactacag
     8941 taaataattt tatatcaata caggccatac aaattgcaga tccaataacc aaaataattg
     9001 attgaggtaa tcgaaaatat ccatcggaaa aagcactttt tacctgggtt atatctgccc
     9061 ctagacgaga tgcaatctca cctttggacc attgttcgac tttaatgata tgcccagaca
     9121 aaaggtgttt tatcaactgg cgacgaaaat tagcagctat attctctcca gcaataccga
     9181 aggtatattg ttccactgct ctagctattg caccgactat caacaacact agtaatgcaa
     9241 acccataagt gcttatagca gggcgatccc ctcctccaag cagctgatta agtaaatagg
     9301 gctgaataat tggggcaata gttgcaatta tagaagaaat aatagccaaa aaaatcacac
     9361 tattacttat tgaagcataa ctaaaaatac ctaccaaacg atttccaata tttttgtgag
     9421 gtttcattcc ttattccttt gagtatttga ttaccataaa acaaaactgc aattcgataa
     9481 tacaatttat ttcatcgagt aaaattgtaa aaaacatgga atacaataga agacattaac
     9541 ccatattttt cacgaatttt agttgccaaa aaagcaaata gcaacatatg taatactgct
     9601 ttctctcgac cgagtggata atgcaataca ccaaacccag caattgacgt cactctatca
     9661 aaagatccat ctatatttcc tcgccaaata atctcttctg ctattgccac tgagataaga
     9721 ttcaaatctt ttagccgctt agtgtctata ttcggcggta gccctgctac ccaacgacta
     9781 acctgagcaa aagtaatccc agtagcggca cccataataa aactactaac attagattta
     9841 cttatatgct tttgttttat atctggaata tctaataatg caagtgcaag tgtaggacca
     9901 tcgtaataga aaaattcagg cgcgttaata cgccataaat ttttaggagc ttttagcgtc
     9961 caaatacaat gcattcctcg taatatacac tggatcatag ttacgcacgt tctcccagtg
    10021 caataatgta catcggaaca tcgtcaatac catttatatc agggagaaaa ctaacaattt
    10081 cgttatcaat gaacccaccg aatatacgcg ttcccagccc caaatcagta gcaacggtta
    10141 gcaagttttg ggctaaatgc ccagattcaa tgcaacaaaa ccgataagct cgctgagcat
    10201 atttaaatct acaccgccat atacttgcgc taataatgat aaatgctgat gcttctttaa
    10261 ttgcatcagg caatagtaaa gcatcacgaa aactgtccaa gtcaatacct tgagccatat
    10321 cagttaggcc atgccgaaat gggtcaaaga aatagaggtt ctctgaagta agacctgtaa
    10381 catcacgtgt tactatgaaa atatccagtg gataaagggc accacctgat ggcgtgtttc
    10441 gacgagtttg cccgccatgc acatcgtagg caccatagga attttccaat actgatgcaa
    10501 gcactgagag cttcagtgat ttttctttaa actgctgtgt ggatcgtcgt tgcgaaagag
    10561 cacgcttgag tgccttagat atctctgtga cctctttgaa tgaagtgaat actctagagt
    10621 cgtaccggcg agcagaacgc atggttgttc tctgcaggtc ttccgattcc atcagagttg
    10681 gaatcattgg agtctcccat gctagccctt cacgagttaa cttagaagct tgaagataat
    10741 tttcggcagg atcattaatt cctggaaccg gtcccccatg tatgagctca cgaatattgg
    10801 acccatgctt ttgtaaaaag tttttatcat tcataatgtg taccttacgg aaatggatgc
    10861 ggccattgat taaaatcggt tatagtaagt tcggtattct tgaatcccat ctcgacaggt
    10921 cgattccgaa gcctcgaccc tccaaggaag cgtcgtccat agccacaatc gagctgctga
    10981 aaaccgtgga taatagtttt gaatacatgt cctccgactt ggctaatatc aggagtcgtc
    11041 aggtcaaaag tgaggactct accattttgc tgtcgagctt tctcaatcag ttccttaagt
    11101 tgaataattt tcgagttaga tttttttaag tcatgtgcat tattcaaggg ctgtagctct
    11161 ccttcgtaga agaacctagc tttgtctgcg gcttctcgcg gaatataaaa catgatgtgg
    11221 tcttcgaaat ctttgatggt ttcatagaga tcatccgtta gattaatatt gctgattcca
    11281 tctcgctgat tggcttttac ccaattgcga gtttgtaagc tttctactga agccgatttg
    11341 cacgcgtcga gtaatgatgc agcagatgat gctccaaatg ctattggagc cacatcggtc
    11401 gtccggttta ctgatactgc aacaaccgtt ggaatctcat tcacctttga gacatcaatc
    11461 agctcgacat caattccaga aggttcgata aaatctttcc aaaaatatcg tagctcttta
    11521 tcgctgtatg gatcgatgcg tggaaaagtt agtccaccat accatgctat acaaaatgca
    11581 tctcgttcag cttgctcata aagcccagag ataatagcgt cgagaggagt ggaatgtgat
    11641 gccaaaccac tacttgtgct atatccaatt ggttttcctt caacttcggc aaaattagtc
    11701 agcaataata acgcagctgg ataatagatt tcagtactat tagttaggtc aaatccacgg
    11761 acccagtgga tcacactatc ttcattgaat tctcgaaatt caaatcgaga atcctcaaac
    11821 tgtgttgggt caaaaagact aatatcattc ggatctattg cttgaaatcc atcattaata
    11881 agctcacggt atgaagcttg tcgttgcaaa tcaaagtgag gataagcgcc acaataacgt
    11941 tcaatagtct caccgacggc tgcaagataa gtttgggtct catcaatcca gccaccacca
    12001 ttatatttgt tggtcgtggt accaagggta aatttagatt ctgcagcagt tgacccgata
    12061 gagaaagtat aagcatcatc ccaatcgtga gtacggtcta cagcacgtac tacgacacca
    12121 tatcgcgaag atgtaacctt tcgtgaaaac tctaaaccta gtttcgtgag gttaacaggc
    12181 ttatcccatt cttttaaata atccaagaat tctgtatatg tcagttttga acgttgtgta
    12241 ttcatttttg ccccatttct ccatgaaacc aaatctgtgg atatccagtg tgtgcagttg
    12301 gagaacattc ttcacatcgc ggtactcgca atatgtaatg attctcggca acgaatccat
    12361 ccatagaatt agaaaaatgg gtagtataac catgtggtgc ctgaccgatg tatccattaa
    12421 gtcctacatg cataatagaa gaacgtgcta tttgagcaga taggatagtc gttgcaagcg
    12481 aatcgtcagc atacaatgaa cgagttactg gcctagcaat agtatccaaa tctggggcaa
    12541 catagttatc gctccagctc acactagttt tacgtagacg atagcaacgg taacatgcgc
    12601 tcgaatgggg ataaatccat ggaccaatct gcgaagatgt acccatcggt ggggaaatag
    12661 gtagccatac tcgccacttc tcttttaggg cagtttcatt tacatgatca aatagctgat
    12721 caccatctgc tgaaccaacg acaagaatta aagatttttc actgagtgca ccaatactct
    12781 ctaactcatt acaaacatgc acattcattc ctgtaccagt tatttcatgc tctatatcat
    12841 ttttaagttg atatgcaaaa tctttctcat ttggtgcaaa aataataatt gttgcagaat
    12901 caagggcaga ttttatttca gaaatttcac acgtaccctc agaatagtta tataggttaa
    12961 gaacaatatt tggccaaggc tcagctttat ctacttgcac taaaatacct gcatcttcta
    13021 gaagaaccag tgctctttcc aaagatgccc gttgttcaaa gtcttctact atctccgaat
    13081 caataatacc accatctgca cacatctgaa gaataaaatc caggagtgta tgatctttaa
    13141 ttttcttgag ggaccgctcg ccgttgatcc aaatattgtc tttattatat tgaatcgtgt
    13201 gggcagtatt aaggcaatat ttcatgtcct tgtccttact tccttttcat tagacctttt
    13261 aggtttccaa cccattcgtc tatttcttgt actgtatttt ggcaaaaaaa tttgttactg
    13321 acaggcccgc tgaaaagact ttgaaagcta gcgagtcgtt cgactgaatc tttttcagca
    13381 aattttatta gcgtctcgac atactctgtt ggtggaagtt caatgtactc aaaaaccgat
    13441 cctgctatat ctttaagttc tttaggatca agttcaaaat caagatatac atcacttacc
    13501 tcaccgatgt ttatttgaga taacccattg cagagagatc ttgttgttgt tgctcgaaat
    13561 ttttcatgag gctccataac taaaaagtag ccaaatcttt gtgcattagc aatatatgca
    13621 gtccaatctt ctggtaaggt tcccatgtat attgttttat gctgtggcgg tagacaggat
    13681 tctacatgat taatccactg tgcatatgct tgattgcatt gttcatagga gataaacgga
    13741 cgtaatacga caagttcatc aataccttcc caggtagtcg actcaatctt ttgtccgacc
    13801 tcctcccaat tcatagtaaa tagatcaatg atctgtctag tggtttgaaa ttcgggaaaa
    13861 cctgcgataa gcctattgac aaagggtcgt gttccaaggt aattagccga catttagttc
    13921 ctttcgagtt attctaataa aaaaaagagt agtgaacggc ttttggtttt gaatagaatt
    13981 ataatcaatt tcctgcggtt ccaaccctat atcgacaaac catttaattt ctgattcaca
    14041 agttgcagac aaatcttcac acaaaatgtt aatatcagac tcagccaaag acgagttgta
    14101 ttgatcaatc ttataccgac tcaagggggc tgcattaagt ggataaggaa tttcacacaa
    14161 ctttaaaagg tctacagcaa tgatctgtcc gcctggtgga agtgcatgcg ctaccttaat
    14221 aagatctcca actggatcgt tccaaagccc aagactcagc acagatgtta ctacatcaac
    14281 atgtgtgttt tgcacataat cgatagcaga ttccgaatcc ccaagatggg ctttacactg
    14341 ttttgagtgt aactcttgta aagattctat gcatttttta tctggatcaa agcctatata
    14401 tgtaaccggg atatcacgat agtacagagc tttaaacaat tctccatacc cacaaccaat
    14461 gtctataagt cgaaacggtt tcattcgaga aacttcacat gctaccattt ttgaatagcg
    14521 taagtcatag ggtttatcat gaccgcgagc aatgtgccgc agcgattcat taacatacca
    14581 atcgctagct gaggttaccc tttgggcttt attcataatt tttctctctt acatgtgcat
    14641 accatttctc gacgccccac cacatcagcg gcgtgaagat gacggcgatg acccagtaca
    14701 cgagccagaa gctgccccta atcccagtca ccaaaatctc agcaacaagc agaaccaccg
    14761 cgattaagca cgccaccacg cacttcttca gctgttgtgc actgtttgcc gcaagtaccg
    14821 ctggggtggc accagaaaat tttctatcga aagtttgaat aatgctacgg ccaaaaacaa
    14881 tggagaacgc aatatagaag gccgcgaacc cgtgcataaa ttccgcagta ctggtctgtc
    14941 gtagcgtgat gaaagaaaac gctagcaaca tcatatcaat caggggagtt gccgctaaaa
    15001 gtgtgattcc aagtttaggc attttcaggg tgtaacggaa tatgcttcct aatactagac
    15061 atacccaaaa catcacctca gtgacgatag ttgctatcag catactcttt cctttagata
    15121 gacgaagata aagacccaca cattctatta tgcaggtctt tatcttcttg acagaccttt
    15181 acatttaact tgcgaaatgg ttaattgctc cagcagcagc aacaaggaac agtgctacaa
    15241 gtgcaacgtg cagcggttgg ttcgaatgcc tttcccgcag tttgaacatt ttcgactgta
    15301 gtatcgaagt gcttgggcaa tgcagctaat aggtcagaca taatattctc cttaaaagaa
    15361 ttatttgatt acaggaataa ttgatgatcc aagaaaaacc aagtactaaa aggcttaacc
    15421 tgaaccttca aatctatcga tattatatat cgataattac accttagcat tacattgagt
    15481 agtgtgtaaa gaattgttta tttgtaaatt aattcttgtt ttgaagctta gtggttggag
    15541 caccttcttg ttatcctgtt tatgccttct gtggtgtggg gtttgtgggt gtgcagggtc
    15601 tcgtaccggg aaatcctgcc cgagaaactc atgagggtca ataaccgggg acgtaagcag
    15661 gtgctgcact actggcagat tgactctagc tatttcaccc tattagggga tgagaacggg
    15721 ctctttgagc tcaccgatac cgcaggggtg gtgtatcggt ttaaaccgca tatagaaccg
    15781 tgccggtatc tgggttctca ggtggcgttt cggttggatt atgggtattg ggctgatccg
    15841 aacaatactc aggatgctga aatacttgtg cagtatattc gggaaaagtt gtgggtgcag
    15901 cgtctgttgg aggtgcccac tgtttcgggg ttagccctag acggggtggg gctagagtat
    15961 aggcctgctg gtggtcctgg tttcgggccc gagttccgta gtaggcagag cgtgtcgggg
    16021 gatttcacct gggccacaaa cttcgtcctc acctaagcct atggttccat aagcgtgaca
    16081 tgcagaaaac ccgtcgggtc ttaagaattt taagatccga cgggcttagt tatgcggtgg
    16141 tggagggatt tgaaccctcg ttggctgtta caccaaacat catttcgagt gatgcacctt
    16201 cggccgctcg gacacaccac caataggata tgattctacc gcatccgccc caagggggca
    16261 aaaactccac ccccttgctc ggtgttccat ccaaggtatg gggacaccct tcaaatcctt
    16321 agcgacaagc gcatcatacc gcttattctg cctgccgaac ttagttcctc acccagggga
    16381 tcgaccttca gtcaagagcg aacccatagc ggctgtgcac cccaatatcg cctgaaagcc
    16441 gcatccgtca gtgccgaata tagccgtcaa ataccagcat gaccgcacgg gttgagtcct
    16501 cgatgctacg ctgcaccccg tgtatctccc ggtccatcgc cagcataaaa gtagcaccaa
    16561 aaatagaaag cgccaacgca cgtgtatcct gggcggtatc gatcgtgtag cggctgcgca
    16621 gggcgcgtac ctgcgactct atgaaatcca ggatttcttg gcggttgtcc accattgagt
    16681 cggtccaggc atccagcccc ttccacactt cgctcaccca gagcctggtg aatcctcggt
    16741 gttcgtgcag ataggtgagc gccgtggaga tgcttttgcg cagcccttcg cgcgggtcgc
    16801 tctgagcgac ggaagcttcg ctcatgctct ccacgagcag gtgcgtgccg tattgcagaa
    16861 gccggtcgat catggttttc ttcgacccga agttgtagta cacggtgcct ttggagaccc
    16921 cggcgcgttg ggcgacctct tcaatgctca cgtgggcgct tccccgatgc tccatgatct
    16981 ccatcgtggc ggtgaagagt ttgcgttggg ttttgccggt gcggcccggt cggcgtgcgg
    17041 ggttcggcgt atcgggcatg gggatggttc ccttcgtggc ggttgctgtt ctctccatac
    17101 taaggcccta tacagtgatt tcggggatta gttttttcag ggaccagatg cggtcgcggc
    17161 gggttcccag gtaccccagc accagaccgg cggcacccca cagcagcagg tacatcatga
    17221 tcggcatcag gctggattcg ttgatgccgt agctgagcct gcgcataccg gtgacggcgt
    17281 agcccatggg gaagaagtcg tgcatccatc tcatggcgtg cggcagggtt tcgtagggca
    17341 tggtgccgcc cgccgtgatg agctgcagga tcatgataat tagggctatg agcttgccgg
    17401 gcgagccgaa gaacaccacc acgccgtgaa tgaacagggt gaagatcgtt gcgacaaagc
    17461 agaggaagaa gaaggcaagc cacggatgcg ccatctggaa tccgagcccg aatttcactg
    17521 ccgcgaacat gagtactgcc tgggcgatac cgatcagtcc gaacggcagc cagcttccta
    17581 ggatgatgcg cgctgtcggt gcctttgagg ccagtgcacg gttgttgagc gggcgcaggg
    17641 tttgcacgag catcagaccg ccgatccaca gggctaggca catgaagaac ggtcccatac
    17701 cctcgccgta attacgtccg ttggctaggg aactgtgttc gaggtccacg ggtgaggaca
    17761 tgacggaggc tacgtctttt tgctgttctt cgttcaagtt ggggatttgg cgggtgccgt
    17821 tgtgcagtcc ggtggagagc tgcccggttc cgtctttgag ctgccccgtg ccgtcggcga
    17881 tttggccggt gctgctgttg agttttccgg tgccatcggc aagctgggac gacccatcct
    17941 gcagtgtggt tgcgccgtcg tgcagtttat tttggccgtc tacggcttct ttttcgccat
    18001 cggcaagctg ctgtgcgccg ttgtgcaggt ttccggtacc gtttttgagt tcgccggtgc
    18061 cctcggccag ttgggatgct ccgttattga gggtggaggc accatcggca actttcccgg
    18121 tgccgtcggc gagtttagct gaaccgtccg ctagggtggt tgccccggaa tcgagtttgg
    18181 tgatgccgtc gcgcagtgtt ccggcaccct gcgctaccgc cgtggcgccg gagtcgagct
    18241 tatccacccc gtcaatcaag gtactgagtt tttgcgctgc agcggattcc ccggtggcca
    18301 cacagttgtc atttttgagg gtttgcagct tcgccaacac atctgaaccg gcttgtccgt
    18361 gctgcgccag atggtttttg agtgcctgat cgttcgcgga tgctacagcc gatttcgtct
    18421 gttcggaatt gatgttggcg acgatcgcgt cggcggtttc ctggctgatg gagccggatt
    18481 cgacgagagg cgctagtttc tgccgggtat cttcggcaac cttagacacc accgtatttg
    18541 acagatctgt gccaaaatcc ccgcttgggg cggaggtgtc gattgagttc aggttttggc
    18601 acatggcggt gagcgttccg ggaagttgac gcactccgtc ctgatccagt gcattcttga
    18661 gcgaatgcgt tccgtcggcg acctgctggg caccttgggc gaggtcgttc gcgcctttct
    18721 taaggctgcc ggtgccgttt gcgagggctg cggagccatc cgccaactgg gaagcgccgt
    18781 tatgcgtgtc agaggcaccg ttggccaggg ttgatgatcc gtcagcgagc ttgaccgcac
    18841 cgtcattgac ttttccggca ccctggttga gggtgcctgc gccgtcagcc aactgggacg
    18901 aaccgtcggc gagcttattt tgcccttcga tgagcctact ggaaccattc accagctgct
    18961 cagacccgtc cgcgagcttg acggcaccat cgttgagggt tccggttccg tcagcgagtt
    19021 gggtcatcgc atcggaaagt ttgacggtgt tcgcgttgat tttgtcggcg ccgtcggctg
    19081 cctcattcat tttgccgtga atggtcgtga agcttgccag cagagtgttc gccgtcttat
    19141 cccccacctt ggaggccacg gaatcccgca cggctgttcc cgccttcgtc acgatgttgg
    19201 tgagcacata gttattggcg tcgttcgtga taatttccag cccggcggcc tgcgggttaa
    19261 tgggaccggt gttgcctttc tcatcaggtt tgaacgagcc ggtactcacg agcctggccg
    19321 agaagtcttt cggaatcacg agcgcaaaat cataggtccc gtcgctgacg ccttggacgg
    19381 ccttatcacg ggtctctacg ctcttccagt cgaaggttcc cgcatccagc aggctctttt
    19441 tgacatccgc accggtgttc agatcgttgc cggaggcatc tttcgcgccc tcgtcttcca
    19501 ccacgagtgc gcccacaata ccgttcacat tcccgtaggc atcccagttg ccgtacaggt
    19561 acagtgaacc gtacagcagc ggaatacacg acatagcaag aagcaccagt accggaagca
    19621 ccccggaggt tagacgctta agttcgacaa gcgcaacacg aactacactc acagttactg
    19681 ttccttctct gctgggttct tcgggtttga taattcttcg agctgttctt cgtggtcttc
    19741 gaggagagcc tcgggtactt cggatgcgtt caccgccgag tcttcctgcg gtgaccgaac
    19801 ggtctgtacc ttcgcgcccg gatcctcgct ctctagcgtc tcgcgatcgt tcgggtcgct
    19861 atgatcgtcg tcgtggtggt ggtcgctgcc gagcaggtca tccagggacg agtcggtttc
    19921 ctcccgcgcg acggtgaggc ggatactctc gcgcgcatcc tgcggggttt cttcaaggtc
    19981 ttcgtgggcg tcaccaacca cggcagtttt gccgtcccag ctttcggaaa tatgcggaac
    20041 tacggcgatc acggcacgag gatcgtcttc gttttcggcg agttcctgca gatacggcag
    20101 ccacatgcgg gtgtggtcca gatgccgtga cggagtatca aataccagaa gatcggagcg
    20161 ggtatgcgcc gctaacgcgc tcatcagacg gatgttctgc tcacctgtaa gctgttcggt
    20221 ccagagccta tcgagctcgc ctaaatcgtt ctgctccagc cagtggcttg ctcggggccg
    20281 accgaagaac ggcagagagt acgagagcat ttcggagacg taatcatgca cgcgcatatg
    20341 cacttcgggg gcggtaactt ctggggaatc aataatgtca gagatactgc gcaggtggcg
    20401 caaactgacg gggcttcggt ggtcccagct gagggttccg ccgctgagct tcagccgccc
    20461 ggtaaggcct aagcttaggg aggtgcgttc aatctggctg tcggcctgta tcaggatgac
    20521 ttcgccgcgt tccaccgtga agctggtacg accgaagagt gccttatggc ggccccgagc
    20581 ccaaatatcg tctgcggtta acatgtgtgc tgaaccttta aatgaatacg tgtcaggatt
    20641 cttggcgcgt ccccgcgtta agtggcacgc aggaccctga attacctcat ctatcgtaga
    20701 tccgcagaaa cagtgcacat gaccattttt tgacgatttc cgatattatt tttgaaattt
    20761 atggattatt tttcaaagaa aaagcgattt tcgttcaaat aaggggggag gaagtcgtac
    20821 cggtcccttt cgcttcctct ctcccctatc gtcctctttg tcttctccga acaaaaggct
    20881 cgtgatgtga ataaaacgtt ggaaaccgtt tgatcacatc acgagccttt tatgaaggca
    20941 caaggatttt aggcaaaaat acccagcggc ttagacccct tgctgcgggc ggcggacttc
    21001 aaaaaatgtg cgcatcagcc cagcacattc ctcgcgcagc accccggcgt aaacctgcac
    21061 atcaagccct aaacgacggt cacggagaac atcatattga ctccccaccg cacccgtttt
    21121 ttcttcccaa gcacccatca ccaccgtggg tatgcgcgcc atcagaatcg ccccggcaca
    21181 catgaggcat ggttcaacgg tcactacgag cgtgcactct tccaatcgcc aggtcttaag
    21241 atgctgtgcc gcctggcgga tcgcgtggat ctcagcgtgc ccggtggggt catgatcgtg
    21301 ttcgcggcta ttgtgccccg aaccgataat ctcaccttcg gcatttacca ccactgcgcc
    21361 gacaggtatc tcaccggcgc atgctgcgcg ctttccttcg tcgagagcca ggcgcatcca
    21421 gcgttcatgc tcagccaatg tcgcaatggt gctgagggct tcaccgtcac cggcgtgagc
    21481 accactattg ttgtattcca tatcgtctat atgtccttgt caaaagctat atattcctca
    21541 tgagaaatac aattctcagt gtgtcacagc cagcgcgaag gggtatacgg cggatgctcc
    21601 acccgcccgc agccgctgcg ccaacacggt gatgctccag cgagaatcca caatatcgct
    21661 cactaaaagc acaggccccg gatgctcacg cagcctctcg atcacctcag gcggaatctg
    21721 gtaggaacgc ataacatcgg cgcatcggaa aacactgtta ccgccgaaga aacgcggttc
    21781 ggcagccagc tcagccttgc ccaaatacac gagtttaccg acatgagcca gcccctcccc
    21841 caacgagcgc gctaacgtgg gacgcaccgg agacggtacc gtgagtacgg tttcggggcg
    21901 gccggtttcg ccccagtccc atgccgcaag aacccgcacg caggcctgcc cgagagcttg
    21961 ggggacgggc gtatcgagag gttctccgga ttcgtcggtc gccaaaagtt cacgcacacg
    22021 gctgccccac cccacatcgc tgaggcgtgc cagcgcgtaa cccggttcgg cgcgctctga
    22081 caccggaatc ttacccttcg gcgcgttctc tcccgcgagc tcctgcagcc cggtaggcca
    22141 catgccgcgc ggggatattt ctacgccgac cgcgttgagt gttccttggg cctgctgcac
    22201 ggcgcgctca gagacctgtt cggggtacca ggggcccgcg cacct
//
