LOCUS       NZ_KV802698            41173 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptococcus sp. HMSC073F11 Scaffold367, whole genome shotgun
            sequence.
ACCESSION   NZ_KV802698
VERSION     NZ_KV802698.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptococcus sp. HMSC073F11
  ORGANISM  Streptococcus sp. HMSC073F11
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 547914)
  AUTHORS   Mitreva,M., Pepin,K.H., Mihindukulasuriya,K.A., Fulton,R.,
            Fronick,C., O'Laughlin,M., Miner,T., Herter,B., Rosa,B.A.,
            Cordes,M., Tomlinson,C., Wollam,A., Palsikar,V.B., Mardis,E.R. and
            Wilson,R.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2016) McDonnell Genome Institute, Washington
            University School of Medicine, 4444 Forest Park, St. Louis, MO
            63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Velvet v. 1.1.06
            Genome Coverage                   :: 213x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001810785.1-RS_2024_11_05
            Annotation Date                   :: 11/05/2024 23:57:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,892
            CDSs (total)                      :: 1,845
            Genes (coding)                    :: 1,788
            CDSs (with protein)               :: 1,788
            Genes (RNA)                       :: 47
            rRNAs                             :: 1, 2, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 3 (16S, 23S)
            tRNAs                             :: 38
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 16 of 57
            Pseudo Genes (incomplete)         :: 34 of 57
            Pseudo Genes (internal stop)      :: 10 of 57
            Pseudo Genes (multiple problems)  :: 3 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:06:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 386886
            Orig. end                         :: 428059
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KV802698.1.
            The WUSC is a large strain collection isolated from clinical
            samples. Each sample is associated with metadata, including source,
            isolation site, 16s rRNA, metabolic, and other phenotypic
            information. The goal is to sample an adequate number of important,
            yet minor species, further adding to the catelogue of sequenced
            bacterial genomes and improving the diversity of the genomes
            available to the public. WGS will be preformed on approximely 550
            isolates. Samples were selected based on RDP analysis at the genus
            level. This is a reference genomes for the Human Microbiome Project
            and the work was funded by the National Institutes of Health (NIH)
            grant U54 HG004968.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..41173
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="T3PKS"
                     /region_number="2"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     cand_cluster    1..41173
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..41173
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="False"
                     /core_location="[20000:21173](+)"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..21173
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     gene            193..759
                     /locus_tag="HMPREF2764_RS08690"
                     /old_locus_tag="HMPREF2764_08705"
     CDS             193..759
                     /GO_function="GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001154854.1"
                     /locus_tag="HMPREF2764_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08705"
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_070528872.1"
                     /transl_table=11
                     /translation="MKEFIQTYLNKLDVTTIIENILTKLISLLFLFLLFYIAKKLLYTM
                     VQRIVKPSLKMSRHDVGRQKTISRLLENVFNYTLYFFLLYCILSILGLPVSSLLAGAGI
                     AGVAIGMGAQGFLSDVINGFFILFERQLDVGDEVVLTNGPITVSGKVVSVGIRTTQLRG
                     EDQVLHFVPNRNITVVSNFSRTDQA"
     gene            811..1716
                     /locus_tag="HMPREF2764_RS08695"
                     /old_locus_tag="HMPREF2764_08710"
     CDS             811..1716
                     /GO_function="GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242265.1"
                     /locus_tag="HMPREF2764_RS08695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08710"
                     /product="magnesium transporter CorA family protein"
                     /protein_id="WP_023943579.1"
                     /transl_table=11
                     /translation="MFLEKQLGNGCTWINLDLDKLKKLEDLSEIYGLDKETIEYALDRN
                     ERAHMDYHRETETVTFIYNVLDLEKDKEYYEAIPMTFIVERQRMITISNHKNAYVIDQM
                     SAYLDSHESLSIYKFLFAGLEIISNAYYPVIEEMDKSKDEISALLRQTTTKKNLFALSD
                     LETGMVYLTAAAKQNRLLLEHIQGHALYRRFNDVEREQFDDAMIEAHQLVSMTDLISQV
                     LQQLSASYNNILNNNLNDSLSILTIISVLLAVLAVITGFFGMNVPLPFTEEPNAWIYIL
                     MTSLILWVALSQWLKKITRK"
     gene            1733..2260
                     /locus_tag="HMPREF2764_RS08700"
                     /old_locus_tag="HMPREF2764_08715"
     CDS             1733..2260
                     /GO_function="GO:0008962 - phosphatidylglycerophosphatase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251415.1"
                     /locus_tag="HMPREF2764_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08715"
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="WP_049500248.1"
                     /sec_met_domain="HAD_2 (E-value: 3.3e-17, bitscore: 58.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVIENYMPDFAVEAVYDLTVPSLQAHGIKAVLVDLDNTLIAWNNP
                     DGTPEMKQWLHDLRDAGIRIIVVSNNTKKRVQRAVEKFGIDYVYWALKPFTFGIDRAMK
                     EFHYEKSEVVMVGDQLMTDIRAAHRAGIRSILVKPLVQHDSIKTQINRARERRVKRKIT
                     ETYGPITYKKGI"
     gene            2263..3369
                     /gene="yqeH"
                     /locus_tag="HMPREF2764_RS08705"
                     /old_locus_tag="HMPREF2764_08720"
     CDS             2263..3369
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yqeH"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391231.1"
                     /locus_tag="HMPREF2764_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08720"
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="WP_049492111.1"
                     /transl_table=11
                     /translation="MEEILCIGCGATIQTTDKAGLGFTPQSALEKGLETGEVYCQRCFR
                     LRHYNEITDVQLTDDDFLKLLHEVGDSDALVVNVIDIFDFNGSVIPGLPRFVSGNDVLL
                     VGNKKDILPKSVKPGKISQWLMERAHEEGLRPVDVVLTSAQNKHAIKEVIDKIEHYRKG
                     RDVYVVGVTNVGKSTLINAIIQEITGDQNVITTSRFPGTTLDKIEIPLDDGSYIYDTPG
                     IIHRHQMAHYLTAKNLKYVSPKKEIKPKTYQLNPEQTLFLGGLGRFDFIAGEKQGFTAF
                     FDNELKLHRTKLEGASAFYDKHLGTLLTPPNSKEKEDFPKLVEHLFNIKDKTDLVISGL
                     GWIRVTGTAKIAVWAPEGVAVVARKAII"
     misc_feature    3459..3477
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.54"
                     /tool="antismash"
     misc_feature    3527..3541
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     misc_feature    complement(3560..3569)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            3582..3893
                     /gene="yhbY"
                     /locus_tag="HMPREF2764_RS08710"
                     /old_locus_tag="HMPREF2764_08725"
     CDS             3582..3893
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="yhbY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060164.1"
                     /locus_tag="HMPREF2764_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08725"
                     /product="ribosome assembly RNA-binding protein YhbY"
                     /protein_id="WP_045612188.1"
                     /transl_table=11
                     /translation="MSLTSKQRAFLNSQAHTLKPIIQIGKNGLNDQIKTSVRRALDARE
                     LIKVTLLQNTDENIHEVAEILEEEIGVDTVQKIGRILILFKQSSKKENRKISKKVKEI"
     gene            3945..4574
                     /locus_tag="HMPREF2764_RS08715"
                     /old_locus_tag="HMPREF2764_08730"
     CDS             3945..4574
                     /EC_number="2.7.7.18"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151307.1"
                     /locus_tag="HMPREF2764_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08730"
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="WP_070528875.1"
                     /sec_met_domain="CTP_transf_like (E-value: 3.5e-37,
                     bitscore: 122.8, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIELLTPFTKVELEPEIKEKKRKQVGILGGNFNPVHNAHLIVAD
                     QVRQQLGLDQVLLMPEYQPPHVDKKETIPEHHRLKMLELAIEGIEGLAIETIELERKGI
                     SYTYDTMKILTEQHPDTDYYFIIGADMVDYLPKWYRIDELVDLVQFVGVQRPRYKAGTS
                     YPVIWVDVPLMDISSSMVRDFLAQGRKPNFLLPQPVLDYIEKEGLY"
     gene            4574..5167
                     /gene="yqeK"
                     /locus_tag="HMPREF2764_RS08720"
                     /old_locus_tag="HMPREF2764_08735"
     CDS             4574..5167
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331212.1"
                     /locus_tag="HMPREF2764_RS08720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08735"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_070528877.1"
                     /transl_table=11
                     /translation="MAYQNYINCSREALLEKMAELLPEKRLTHCLGVERAAIELAQRFE
                     IDAEKAGLAGLLHDYAKKLSDQEFLNLINRYQLDLDLKNWGNNVWHGMVGIYKIQEDLD
                     LHDPEILRAIEIHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAREIATLSLNKAVAY
                     ETARTVEHLAHQGFPIYPKTLETYNAFVHYLKED"
     gene            5168..5521
                     /gene="rsfS"
                     /locus_tag="HMPREF2764_RS08725"
                     /old_locus_tag="HMPREF2764_08740"
     CDS             5168..5521
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0017148 - negative regulation of
                     translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rsfS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003018.1"
                     /locus_tag="HMPREF2764_RS08725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08740"
                     /product="ribosome silencing factor"
                     /protein_id="WP_070528879.1"
                     /transl_table=11
                     /translation="MNEKELLELVVKAADEKRAEDILALDVQDLTSVTDYFVITSSMNS
                     RQLDAIADNIREKVAEAGFKGSHIEGDATGGWVLLDLGSVVVHIFSEEMRAHYNLEKLW
                     HEANSVDISATLA"
     gene            5632..6372
                     /locus_tag="HMPREF2764_RS08730"
                     /old_locus_tag="HMPREF2764_08745"
     CDS             5632..6372
                     /NRPS_PKS="Domain: oMT (36-138). E-value: 2.1e-09. Score:
                     27.8. Matches aSDomain:
                     nrpspksdomains_HMPREF2764_RS08730_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257057.1"
                     /locus_tag="HMPREF2764_RS08730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08745"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_070529192.1"
                     /transl_table=11
                     /translation="MATYETFAAVYDAVMDDSLYDKWTDFSLRHLPKTKDRKKLLELAC
                     GTGIQSVRFSQAGFDVTGLDLSADMLKIAEKRAASAKQKIDFIEGNMLDLSKAGQYDFV
                     TCYSDSICYMQDEVEVGDVFKEVYNALNEDGVFIFDVHSTYQTDEIFPGYSYHENAEDF
                     AMLWDTYEDEAPHSIVHELTFFIKEADGSFSRHDEVHEERTYEILTYDILLEQAGFKSF
                     KLFADFEDKEPTETSTRWFFVAQK"
     aSDomain        5740..6045
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HMPREF2764_RS08730_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.10E-09"
                     /label="HMPREF2764_RS08730_oMT.1"
                     /locus_tag="HMPREF2764_RS08730"
                     /protein_end="138"
                     /protein_start="36"
                     /score="27.8"
                     /tool="antismash"
                     /translation="RKKLLELACGTGIQSVRFSQAGFDVTGLDLSADMLKIAEKRAASA
                     KQKIDFIEGNMLDLSKAGQYDFVTCYSDSICYMQDEVEVGDVFKEVYNALNEDGVFI"
     misc_feature    complement(6377..6390)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.83"
                     /tool="antismash"
     gene            6382..6774
                     /locus_tag="HMPREF2764_RS08735"
                     /old_locus_tag="HMPREF2764_08750"
     CDS             6382..6774
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153606.1"
                     /locus_tag="HMPREF2764_RS08735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08750"
                     /product="hypothetical protein"
                     /protein_id="WP_070528882.1"
                     /transl_table=11
                     /translation="MVRSKYSWEEVSQFNRIRQNGTLWEKDGQYFYVQEEGTVFSELVV
                     YDMSKKLFDMLVNEIKSEDDIRHMLMYGTWPMTVAGCHSPTMLIAYPELQKNYSNEQLA
                     EILPVGEKQWLNWRGRLPEWYRRFRH"
     gene            6789..7886
                     /locus_tag="HMPREF2764_RS08740"
                     /old_locus_tag="HMPREF2764_08755"
     CDS             6789..7886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156376.1"
                     /locus_tag="HMPREF2764_RS08740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08755"
                     /product="nucleotidyltransferase"
                     /protein_id="WP_070528889.1"
                     /transl_table=11
                     /translation="MTITGIIAEFNPFHNGHKYLLDQAKGLKIVAMSGNFMQRGEPAIV
                     DKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVYILARLGIDTLAFGTEEVVDYQ
                     KIADLYTEQGADMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYVKAV
                     AGLNIKLHPIQRQGAGYHSVDKDVDFASATALRQHQKDQDFLERFMPSVALFEQASKVN
                     WEDYFPMLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSLEELVEAVATKRYTKARV
                     RRLLTYILVQARESDLPEGIHVLGFTEKGRQHLKSLKGQVHLVSRIGKEPWDSMTQKAD
                     QIYQLGNPGIAEQNFGRVPIRIETN"
     gene            8088..9701
                     /locus_tag="HMPREF2764_RS08745"
                     /old_locus_tag="HMPREF2764_08760"
     CDS             8088..9701
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520539.1"
                     /locus_tag="HMPREF2764_RS08745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08760"
                     /product="ribonuclease Y"
                     /protein_id="WP_000404934.1"
                     /transl_table=11
                     /translation="MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSQEAAELMLLNAEQE
                     ATNLRGQAEREADLLVNEAKRESKSLKKEALLEAKEEARKYREEVDAEFKSERQELKQI
                     ESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAELER
                     IGALSQAEARDIILAQTEENLTKEIASRIREAEQEVKERSDKMAKDILVQAMQRIAGEY
                     VAESTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFDPIRRE
                     IARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEAAAYEIGAPNLHPDLMKIM
                     GRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAIDREVEGSH
                     VEIGMELARKYKEHPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGARSESLESY
                     IKRLHDLEEIANGFEGVQNSFALQAGREIRIMVNPGQIKDDKVTILAHKVREKIENNLD
                     YPGNIKVTVIRELRAVDYAK"
     gene            9831..10457
                     /gene="gmk"
                     /locus_tag="HMPREF2764_RS08750"
                     /old_locus_tag="HMPREF2764_08765"
     CDS             9831..10457
                     /EC_number="2.7.4.8"
                     /GO_function="GO:0004385 - guanylate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006163 - purine nucleotide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="gmk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775037.1"
                     /locus_tag="HMPREF2764_RS08750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08765"
                     /product="guanylate kinase"
                     /protein_id="WP_070528891.1"
                     /transl_table=11
                     /translation="MVDRGLLIVFSGPSGVGKGTVRREIFESSENQFQYSVSMTTRAQR
                     PGEVDGVDYFFRTREEFEELIRQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIE
                     VQGALQVKKKVPDAVFIFLTPPDLDELQDRLVGRGTDSAEVIAQRIEKAKEEIALMREY
                     DYAIVNDQVPLAADRVKRVIEAEHFRVDRVIGHYQEMLPKSPTTR"
     gene            10482..10793
                     /gene="rpoZ"
                     /locus_tag="HMPREF2764_RS08755"
                     /old_locus_tag="HMPREF2764_08770"
     CDS             10482..10793
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rpoZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817694.1"
                     /locus_tag="HMPREF2764_RS08755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08770"
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="WP_070528894.1"
                     /transl_table=11
                     /translation="MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSEK
                     STLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKRRKEEEKKIKEQIAKEKEDGEKI"
     gene            10859..13255
                     /locus_tag="HMPREF2764_RS08760"
                     /old_locus_tag="HMPREF2764_08775"
     CDS             10859..13255
                     /EC_number="3.6.1.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0032508 - DNA duplex unwinding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001162119.1"
                     /locus_tag="HMPREF2764_RS08760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08775"
                     /product="primosomal protein N'"
                     /protein_id="WP_070528898.1"
                     /transl_table=11
                     /translation="MAIAKIIVDVPLMQTDQPYSYRIPKEFEGMLEVGMRVHVPFGKGN
                     RLIQGIVLGLESQPDEEEANHDLKDIAEVLDFSPVLTQEQLWLAEELRKSVFSYKISIL
                     KAMLPGFLNSSYDKILYPLAGLSQEDRERLFGSEDSLAFSSLDLAKQAEMMRLTRKGLL
                     GLEYQAIDQKKVKTQSWYEVDLAQLESVEISTRAKKKLELRDYLLSHPESASLASLLES
                     YSREQVNFFVEQGAVTIVQKEVQRSAAYFEGIEASQPLELNPEQRQARDAVVSAIGSHQ
                     APFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARFGDKVAIL
                     HSGLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNLGVMIIDEEHEATYKQDSNPRY
                     HAREVAILRARYNQAALVLGSATPSLESRARAGKGVYQHLCLTQRANPLATIPEVQVID
                     FRDYIGQNETSNFTPPLLEAIQDRLAKKEQVVLMLNRRGYSSFVMCRECGTVDTCPNCD
                     ISLTLHMDTKTMNCHYCGFSKDIPQVCPNCKSRSIRYYGTGTQKAYDELAELFPQARIL
                     RMDVDTTRKKGSHQALLDQFGRGEADILLGTQMIAKGLDFPNVTLVGVLNADTALNLPD
                     FRSSERTFQLLTQVAGRAGRAEKAGQVLIQSYNPQHYAIRFAKDQDYEGFYAYEMGIRR
                     QLGYPPYYFTIGITLSHKKEEEVVKRAYEVMSVLRSGLSETSKILGPTPKPIARTHNLY
                     HYQILIKYRLEDELGPTLNRVLALTQERENSELRLSIDHEPQQFL"
     gene            13268..14203
                     /gene="fmt"
                     /locus_tag="HMPREF2764_RS08765"
                     /old_locus_tag="HMPREF2764_08780"
     CDS             13268..14203
                     /EC_number="2.1.2.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004479 - methionyl-tRNA formyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0071951 - conversion of methionyl-tRNA to
                     N-formyl-methionyl-tRNA [Evidence IEA]"
                     /codon_start=1
                     /gene="fmt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228: methionyl-tRNA formyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163675.1"
                     /locus_tag="HMPREF2764_RS08765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08780"
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="WP_070528901.1"
                     /transl_table=11
                     /translation="MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKVI
                     QETPVKQAAKEAGLPIYQPEKLSGSPEMEAIMNLGADGIVTAAFGQFLPSKLLDSMDFA
                     VNVHASLLPKHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDEDNVG
                     TLFEKLALVGRDLLLDTLSAYIAGEIKPEPQDPSQVTFSPNIKPEEEKLDWTKSNRQLF
                     NQIRGMNPWPVAHTFLKGDRFKIYEALLVEGKGNPGEILSIGKKELIVATAEGALSLKQ
                     VQPAGKPKMDIASFLNGLGRTLTVGERFGD"
     gene            14196..15509
                     /gene="rsmB"
                     /locus_tag="HMPREF2764_RS08770"
                     /old_locus_tag="HMPREF2764_08785"
     CDS             14196..15509
                     /EC_number="2.1.1.176"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001510 - RNA methylation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255437.1"
                     /locus_tag="HMPREF2764_RS08770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08785"
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="WP_070529196.1"
                     /transl_table=11
                     /translation="MTKVETARSLALAALEDVFINQAYSNIALNKHLKGSQLSAADKGL
                     VTEIVYGTVARKLTLEWYLSHFIEDRDQLDSWLYVLLLMSAYQLRYLNKIPDHAVVNEA
                     VELAKVRKKGSEKLANAVLRRILREGWPDITSIKRKNKRDSIAYSLPVWLVSKLKEEYG
                     EERAQAIFESLLVRNKASIRVTDLSRKEEIQALLEASDSSLSSSGLVKEQGHFAGHDLF
                     AEGAITIQDESSQLVAPTLDLQGDEKVLDACAAPGGKTAHIASYLTTGQVTALDLYDHK
                     LDLIQENAQRLGVADRVQRQKLDARKVHEFFGQDSFDKILVDAPCSGIGLLRRKPDIKY
                     NKETADFASLQEIQLEILGSVCQTLRKGGIITYSTCTIVSEENFQVVEAFLESHPEFEQ
                     VELEHECKDIMKDGCILITPELYGSDGFFISQFRKISD"
     gene            15524..16264
                     /locus_tag="HMPREF2764_RS08775"
                     /old_locus_tag="HMPREF2764_08790"
     CDS             15524..16264
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397383.1"
                     /locus_tag="HMPREF2764_RS08775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08790"
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="WP_000406242.1"
                     /transl_table=11
                     /translation="MEISLLTDVGQKRTNNQDYVNHYVNRAGRTMIILADGMGGHRAGN
                     IASEMAVTDLGIAWVDTQIDTVNEVREWFANYLEIENQKIHQLGQDDAYKGMGTTLEAV
                     AIIGNQAIYAHIGDSRIGLIRGEEYHQLTSDHSLVNELLKAGQLTPEEAASHPQKNIIT
                     QSIGQKDEVQPDFGMITLEPGDYLLLNSDGLTNMISGSEICDIVTSDIPLADKTATLVR
                     FANNAGGLDNITVALVSMNEEDAE"
     gene            16261..18162
                     /gene="pknB"
                     /locus_tag="HMPREF2764_RS08780"
                     /old_locus_tag="HMPREF2764_08795"
     CDS             16261..18162
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000614559.1"
                     /locus_tag="HMPREF2764_RS08780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08795"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_070528904.1"
                     /sec_met_domain="Pkinase (E-value: 7.7e-57, bitscore:
                     187.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLR
                     TNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYIKE
                     HYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVAFAE
                     TSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIAL
                     QHFQKPLPSVIDENPSVPQALENVVIKATAKKLTDRYQSVAEMYVDLSSSLSYNRRNEP
                     KLVFNDTTKADTKTLPKVSQSTLTSIPKVQTQSPKPQTAKPSQQVSEDNYASKTVKKRK
                     FRVRYMILLASIVLVAASLIWILSRTPATIAIPDVAGQTVAEAKETLKKANFEIGEEKS
                     EASEKVEEGRIIRTDPEAGKTRKEGSKINLVVSSGKQSFQLSNYIGRKSTDVIAELKQK
                     KVPENLIKIEEEESSESEAGTVLRQSPAAGTTYDLSKASTITLTVAKKVTSVAMPSYIG
                     SSLEFTKNNLVQIVGIKEANIEVVEVSTAPDGTAEGTVVEQSPKAGEKVDLTKTRVKIS
                     IYKPKTPPSTSSSAPAQRGNQGSTTTPSQGNQQGNQRGNAPATTQSSSEGNHENSRD"
     gene            18251..19009
                     /locus_tag="HMPREF2764_RS08785"
                     /old_locus_tag="HMPREF2764_08800"
     CDS             18251..19009
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392945.1"
                     /locus_tag="HMPREF2764_RS08785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08800"
                     /product="threonine/serine exporter family protein"
                     /protein_id="WP_033686493.1"
                     /transl_table=11
                     /translation="MEESRELNAVIDVIMLAGTILLKSGSEIHRVEDTMIRIAHSQGIV
                     DCNVLAMPAAIFFSIENTNISRMKRVTSSSYNIEKVCDVNQISRQLVGGNLDLETAFKQ
                     LTALQDQPLPYTKLQVTLAATFSAPFFSIMFSGNIYDALGAGVATLFGFAFSLYVEKFI
                     RIPFVTAFAGAFVFGMIAQFWARYTGFPSTADLIIAGAVMPFVPGIALTNAVRDIMTNH
                     INSGMSKMFESLLITLALGAGTSVALVLMN"
     gene            19011..19451
                     /locus_tag="HMPREF2764_RS08790"
                     /old_locus_tag="HMPREF2764_08805"
     CDS             19011..19451
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000176930.1"
                     /locus_tag="HMPREF2764_RS08790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08805"
                     /product="threonine/serine exporter family protein"
                     /protein_id="WP_000176930.1"
                     /transl_table=11
                     /translation="MTLTTFLLQAVASLLAIITFLIVLNVQRSMLLPGGILGMAVWLIY
                     LLLKEPTNVIVATFIAAIIGSCVSQILSILYKTPAVVFILAILAPLVPGYLSYRTTAFF
                     VTGDYSHAIASATLVVMLALVISIGMASGTVILRLYHYIKTH"
     misc_feature    complement(19479..19493)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 27.71"
                     /tool="antismash"
     gene            19621..19869
                     /locus_tag="HMPREF2764_RS08795"
                     /old_locus_tag="HMPREF2764_08810"
     CDS             19621..19869
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /locus_tag="HMPREF2764_RS08795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08810"
                     /product="hypothetical protein"
                     /protein_id="WP_070529199.1"
                     /transl_table=11
                     /translation="MVSSSSSEFQSGLQENQLIAEKVSKTLDKTFDKNIREIPTSQFYQ
                     EFVDEMGRTYSGNLILQELLTENGAYKATYVGELYSN"
     gene            20001..21173
                     /locus_tag="HMPREF2764_RS08800"
                     /old_locus_tag="HMPREF2764_08815"
     CDS             20001..21173
                     /EC_number="2.3.3.10"
                     /GO_function="GO:0004421 - hydroxymethylglutaryl-CoA
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043: hydroxymethylglutaryl-CoA synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /locus_tag="HMPREF2764_RS08800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08815"
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="WP_070528909.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 5.2e-09,
                     bitscore: 30.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIA
                     PLTEDIVTLAASASDSILTEQERQEIDMVIVATESGIDQSKAAAVFVHGLLGIQPFARS
                     FEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAMLIT
                     QNPRIMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQL
                     TLDDFAAVCFHLPYPKLALKGLKKIMDKSLAQEKKDLLQKHFDQSILYSQKVGNIYTGS
                     LFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRT
                     ALSVADYEKVFFEEVDLDETNSAQFAGYENQDFALVEIVDHQRRYSKVEK"
     gene            21173..22447
                     /locus_tag="HMPREF2764_RS08805"
                     /old_locus_tag="HMPREF2764_08820"
     CDS             21173..22447
                     /EC_number="1.1.1.88"
                     /GO_function="GO:0004420 - hydroxymethylglutaryl-CoA
                     reductase (NADPH) activity [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0015936 - coenzyme A metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1187: hydroxymethylglutaryl-CoA reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /locus_tag="HMPREF2764_RS08805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08820"
                     /product="hydroxymethylglutaryl-CoA reductase, degradative"
                     /protein_id="WP_070528913.1"
                     /transl_table=11
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEQDEQMSVTVA
                     DQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFTAQ
                     VHERQMIGQVALYQVADPDLVQEKIDGKKVELLELANQAYPSIVKRGGGARDLHVEKIK
                     AETDFLVVYLHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSLVTAN
                     CRIAFRYLSRQTDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWR
                     AIEAGAHVFASRDGHYQGLSQWTLDLEREELVGEMTLPMPVATKGGSIGLNPRVALSHE
                     LLGNPSAKELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLSLLAGASESEVAP
                     LVELLIADKTFNLETAQRYLENLRS"
     assembly_gap    22517..22616
                     /estimated_length=unknown
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(22645..23610)
                     /locus_tag="HMPREF2764_RS08810"
                     /old_locus_tag="HMPREF2764_08825"
     CDS             complement(22645..23610)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /locus_tag="HMPREF2764_RS08810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08825"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_023946516.1"
                     /transl_table=11
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMRELG
                     YKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDSEK
                     EREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAGGLL
                     AAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKEMEIK
                     NILTHQKPDAIFASDDLTAILVIKIAQELGISVPEELKVIGYDGTYFIENYYPQLATIK
                     QPLEEIACLTVDLLLQKIAGKEVATTGYFLPVTLLPGKSI"
     gene            complement(23591..25045)
                     /locus_tag="HMPREF2764_RS08815"
                     /old_locus_tag="HMPREF2764_08830"
     CDS             complement(23591..25045)
                     /EC_number="3.2.1.26"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004564 - beta-fructofuranosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /locus_tag="HMPREF2764_RS08815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08830"
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="WP_070528919.1"
                     /transl_table=11
                     /translation="MKWTTERRYRLYQDWTQEEIKNIKENMAQSPWHTHYHVEPKTGLL
                     NDPNGFSYFDGKWIVFYQNFPFGAAHGLKSWVQLESEDLVHFTETGVKVLPDTPLDSHG
                     AYSGSAMQFGDQLFLFYTGNVRDENWIRHPYQIGALMDKDGKITKIDKILIDQPADSTD
                     HFRDPQIFNFKGQYYAIVGGQDLEKKGFVRLYKSVDNDYTSWQAVGNLDFANDRTAYMM
                     ECPNLVFVGEQPVLLYCPQGLDKKVLDYDNIYPNMYKIGASFDPENAKMVDVSQLQNMD
                     YGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDHFDHQGIFSLVKELTIKDGKLYQYP
                     VAAVKDLRASEEAFSNRAQTNNTYELELSLEANSQSEIVLLADQEGKGLSINFDLVNGQ
                     VTVDRSQAGEQYAQDFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVFSGRVFPHA
                     DQNGILIKSGNPTGTYYELDYGRKTN"
     misc_feature    complement(25082..25093)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            25424..27310
                     /locus_tag="HMPREF2764_RS08820"
                     /old_locus_tag="HMPREF2764_08835"
     CDS             25424..27310
                     /EC_number="2.7.1.211"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /locus_tag="HMPREF2764_RS08820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08835"
                     /product="sucrose-specific PTS transporter subunit IIBC"
                     /protein_id="WP_070528922.1"
                     /transl_table=11
                     /translation="MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEGKINKEVI
                     ENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVALGLPTSSKDDMKAEAAKQGNWFQRA
                     IRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPGLVV
                     WSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGSVLPA
                     FIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYILIATK
                     AILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAAMTAQGA
                     ATVAVGIKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAGAIGGGLA
                     SILGLAGNGSGITIIPGTMLYVGNGQLAQYLLMVAVSFALGFALTYMFGYEDEKEVATE
                     VETERLVQEETTGNIPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQGIAVKPSQG
                     VVYAPADAEVSIAFATGHAFGLKTTNGAEVLIHVGIDTVTMNGEGFEQKVAQGDKVKAG
                     DVLGTFDSNKIAAAGLDDTTMIIVTNTADYASVAPVATGSVAKGDAVIEVKI"
     assembly_gap    27348..27447
                     /estimated_length=unknown
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            27634..28521
                     /gene="scrK"
                     /locus_tag="HMPREF2764_RS08825"
                     /old_locus_tag="HMPREF2764_08840"
     CDS             27634..28521
                     /EC_number="2.7.1.4"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008865 - fructokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scrK"
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /locus_tag="HMPREF2764_RS08825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08840"
                     /product="fructokinase ScrK"
                     /protein_id="WP_070528928.1"
                     /transl_table=11
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKTI
                     EFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPMYF
                     TTDVNSSAYGEVVARNNAGARIENLVYYTIGTGIGAGVIQRGEFIGGAGHPEMGHYYVA
                     RHPMDIEKEFKGVCPFHKGCLEGYAAGPSLEARTGVRGENIELNNPVWDVQAYYIAQAA
                     VNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTPAVAGNGS
                     ATLGNFVLAKEVSK"
     gene            complement(28563..29180)
                     /locus_tag="HMPREF2764_RS08830"
                     /old_locus_tag="HMPREF2764_08845"
     CDS             complement(28563..29180)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /locus_tag="HMPREF2764_RS08830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08845"
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="WP_070528930.1"
                     /transl_table=11
                     /translation="MSQDKQMKAVSPLLQQVINISSIIGGVGSLIFCIWAYQAGVLQSK
                     ETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGIVI
                     GCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADFLCM
                     LAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     misc_feature    29220..29235
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            29312..31957
                     /locus_tag="HMPREF2764_RS08835"
                     /old_locus_tag="HMPREF2764_08850"
     CDS             29312..31957
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152736.1"
                     /locus_tag="HMPREF2764_RS08835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08850"
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="WP_070528937.1"
                     /transl_table=11
                     /translation="MLGLKFNGTWRNYQKQVLDNFQEYQADGHVHLVAAPGSGKTTIGI
                     ELIARFDKPALVLVPTVTIREQWVERIRQAFLEDEDQVTSLVSQNLKDMKQITIATYQV
                     FHSAMQQVQSQEDNGEVEDFIGFDLLDRLKERGVETLCLDECHHLRNEWWKSLEDFRKN
                     YQQLQVISLTATPPYDSEPELWDRYLQMCGEIDQEITVPELVKEDTLCPHQDFVYICFP
                     TKEEDKRLEEFEDTKWQYVSQLVVDPDFQELIRSSKVLKGKISADILLEDPKYLSALLI
                     YLQAQKQEIPTHLQDLLGAEGLPALNYYWLEILLQGLLYQTPDWYEDQQETKKKIEAEL
                     KSRGLIEKRQVFLVKSKANDQILNQSLGKLAGIASIFETEYDSLGKDLRQLVLADYIRK
                     DFASYLGDDQAPITQLGVLPYFETIRRSAQKQGLSVPIAVLSGSVVIIPASVKAELQAL
                     IPNTSLSFSAIGKLDQDVYLQVGFPSSFKGMVAAVTELFQRGSIQVLVGTKSLLGEGWD
                     APCVNSLILGSFVGSFMLSNQMRGRAIRIWPGHPDKTSNIWHLVAIKPYKNPAFSKEDQ
                     EELDLNPYQDLQTLARRMDHFLGLSYKEDTIETGLDRLNFPEFPFKKKKLEDYNEKIME
                     LSKDRASLRKKWQESLIVADKIEIVNEVATDSKRIPLLALADAEKWLRYALMVFAISLL
                     AYVVRLTFFALPWLTALCVLFLAITAFRYYSYKSPYKRLRQIGEAIRKVMVTAGHLSDD
                     QSRVQVEEDKESFNVFSYLKGGSMRDKELFSQTLGEFFAPVDNQRYLLVVKKAPAGQSK
                     YFVVPSLFEKRKEDAQLFLDAVAPQIGDYQLVYTRNEVGRKILLEARLKSLANKNDRII
                     TKKKVKSALK"
     gene            <32186..33139
                     /locus_tag="HMPREF2764_RS08840"
                     /old_locus_tag="HMPREF2764_08855"
                     /pseudo=""
     CDS             <32186..33139
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001197391.1"
                     /locus_tag="HMPREF2764_RS08840"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08855"
                     /product="type I restriction endonuclease subunit R"
                     /pseudo=""
                     /transl_table=11
                     /translation="YWQIITFQKPLAFKEAVDNALKLYSNGGENEVLAPSWEEEKRNFL
                     RSCSDFQNLITDDPEEGLQIEQISTPELRKLAKAYQVFDKYLASIRVYKEYDEEEIYAQ
                     TGLSAEELETYLGFYQNILAELKSRRDDGGEDGEPLDIHYELESIQVDEINYAYILTLI
                     QSLIEQGQSQEKNLSAQDREAVDSYIQSLEKINPNLAHIITELWKEVQDKSESYRGQSI
                     ANILDQMIEAVIQQHIQVFSKRWYVGEDELRYYVEHYRKGAKKQLGESQLTKSQRYQDY
                     KIEVADALNPLLYKKQIKEACKQLVEEVIEPLRVGR"
     gene            33548..33763
                     /locus_tag="HMPREF2764_RS08845"
                     /old_locus_tag="HMPREF2764_08860"
     CDS             33548..33763
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710793.1"
                     /locus_tag="HMPREF2764_RS08845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08860"
                     /product="hypothetical protein"
                     /protein_id="WP_070528942.1"
                     /transl_table=11
                     /translation="MKRDKENEESILSDLPLWGLLFLVCVLLQVYVGKDRPLIQPDRQG
                     SIVKTNQKQVYLPELIQSLFDKEKTK"
     gene            33789..34550
                     /locus_tag="HMPREF2764_RS10170"
                     /old_locus_tag="HMPREF2764_08865"
     CDS             33789..34550
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161227.1"
                     /locus_tag="HMPREF2764_RS10170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08865"
                     /product="DUF6261 family protein"
                     /protein_id="WP_070528945.1"
                     /transl_table=11
                     /translation="MTKTFTIRPLSYTNFTNREFESLMVDTGQLLEVFAKAHKDESMYS
                     KHLDSFKSKLADFQAQLAIVEKKEATNLTEVDRNRDSALVGLFTLHRGFAKIKETKLKE
                     AHETLKPVFAKYKDITKHSNDVETAEIKSLLKTLSEEPYQTAVTSLGLTPMLTAVISAQ
                     EEYDKVESQARAHKSAKEVGKTRQVRTELTSIYVLFMRYTAASAEAYPEKEHLTKLLKD
                     LNTIRDSKRRLTGSSKKDKKVKTEETTQVAG"
     gene            34663..36507
                     /locus_tag="HMPREF2764_RS08855"
                     /old_locus_tag="HMPREF2764_08870"
     CDS             34663..36507
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342691.1"
                     /locus_tag="HMPREF2764_RS08855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08870"
                     /product="P-loop NTPase fold protein"
                     /protein_id="WP_070528947.1"
                     /transl_table=11
                     /translation="MDDRFITLKHIDTSVAAKNVAKLLEENKTYFLNGNWGSGKTEFLV
                     EVGKNTNKKLVTIDFWRLSDSRSTIEIIFSKLHPWKYRFLRFFIVLCVALSILMTNVVD
                     LGLSSFFESFCVKLIVGSIVLLVAIYQFFKVKSDGFYSRLLTFKYLSLARKVLVIDDFD
                     RMSNKQQEESYKIFSLLSGKLPIVFVGDIEKVHLKDNNFLSKIIDRRIELPFVLHPSNI
                     WQDYFDLLGKKFSTRLSDDFWRRFRFENRNLRDRNHFNDYVNQEFFSRGKLGHVQEEQQ
                     LWIIYTYLFYPELYKQLLKAEEIKVKDDEKISFTWLFKFGRSIEEILSDIQQSDLTQYP
                     PSYKMNSSAYFLYEESLNRTKEELDSLLETDSEELSRELREGNHKTDFYQYLSSEYKSF
                     SENQKAKLLRITIQESLKSYNSPAMDYIVAEKLNEEIPRYERNSPLSEEIIGRIVNFWE
                     TILRKEGLDPSEILYFMEKHRVLTFYDLGRHYSNLEINNKNFAKLRRKDFFLLTYLSSI
                     EKFNEFESWDRSIWDAMEQFGGREFLVFWEFQGILSNGLGYYCFDVVPRNKKYFLMMDE
                     NQDKMKNNKSVIEKIQPQLEQLEAKGFTFEEKIDREYW"
     gene            36685..38256
                     /locus_tag="HMPREF2764_RS08860"
                     /old_locus_tag="HMPREF2764_08875"
     CDS             36685..38256
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146974.1"
                     /locus_tag="HMPREF2764_RS08860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08875"
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_070528950.1"
                     /transl_table=11
                     /translation="MASKENAERKVLHRKIWAIADDVRGAVDGWDFKQYILGILFYRFI
                     SEHMADYFDRAEHEAGDLEFRYAELSDQEAEQDFKPGTVEDKGFFILPSQLFENVVENA
                     SQNENLNEDLANIFQAIEKSAIGFKSEDDIKGLFDNLDTRSNILGGSVPEKNKRLSDIL
                     NGINSINFGNFEENDIDAFGDAYEFLISNYASNAGKSGGEFFTPQTVSKLLARLVMVGK
                     DKINKVYDPTCGSGSLLLQMKKQYEDHILEDGFFGQEINMTNYNLARMNMFLHNINYNN
                     FDIKRGDTLLNPQHLEEKPFDAIVSNPPYSVKWVGDGDPTLINDDRFAPAGKLAPKSKA
                     DFAFIMHSLNHLSNKGRAAIVCFPGIFYRGGAEKTIRQYLVDNNFVEAVIALPDNLFFG
                     TSIATTILVLAKNKLENKTLFIDASKEFKKETNNNVLTDSNIEYIVELFSNYQNVDYKA
                     TLVDNEVIGSEQDYNLSVSTYVEQEDTREKIDIDMLNKEIAETVTKIDHLRAEIDKIVE
                     ELSHGK"
     gene            38246..39250
                     /locus_tag="HMPREF2764_RS08865"
                     /old_locus_tag="HMPREF2764_08880"
     CDS             38246..39250
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001262594.1"
                     /locus_tag="HMPREF2764_RS08865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08880"
                     /product="virulence RhuM family protein"
                     /protein_id="WP_070528953.1"
                     /transl_table=11
                     /translation="MANDVILYRTDDGKSAIELHLDNGTVWLTQQELAELFQTSKQNIS
                     KHIKAIFEDGELDETVVVNYQLTTTRHGAMAGKTQSKKVAYYNLDMILAIGYRVRSPRG
                     VQFRHYASTVLKEYLIKGFAMDDERLKNLGGGSYFKELLERIRDIRSSEKVFYRQVLDL
                     FATSSDYNANSPEAKKFFATVQNKMHYAIHHNTASELIYNRVDSEKEFMGLTTFKGDLP
                     TLSEAKVAKNYLTEKELRGLNQLVSGYLDFAERQAEREEVMTMADWVTHVDRILQATGE
                     DLLDNSGSISREQMKQKVDKEYKSYQAKTLSQVEKDYLKEIKSIENLAKEGGN"
     gene            39250..40434
                     /locus_tag="HMPREF2764_RS08870"
                     /old_locus_tag="HMPREF2764_08885"
     CDS             39250..40434
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729863.1"
                     /locus_tag="HMPREF2764_RS08870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08885"
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_070528956.1"
                     /transl_table=11
                     /translation="MNILEEIQNCPVEWKELGEVCSVKKGKQLNKNLLTEDGLYPAYNG
                     GQTYSGRTNDYNVEANTIIVSQGGASAGFVNFVDTKFWANAHCYYILPDETRVNNRFVY
                     HFVKMNQKYLMDFQHGAGIPALKADKLSKLLLPIPPLEIQEKIVQILDKFTDYVTELTS
                     ELTSELTSRKKQYSYYRDKLLSFEDEVYQVEWKTLGEVAKFNYGYTDKAKDIGDVRFIR
                     ITDIDENGYLKPYDKKYIALTEASRSYLVKYGDLLMARTGATFGKTLFIDTDETSAYAS
                     FLIKITPSEKLNSRYYWHFSKSELYWKQANNLVSKAGQPQFNANSLKNVKIPVPSLEIQ
                     SRIVQVLDNFDTVCNDLNIGLPKEIELRQKQYEYFREKLLTFVAEGEYTESRVE"
     gene            40549..41061
                     /locus_tag="HMPREF2764_RS10205"
                     /old_locus_tag="HMPREF2764_08890"
     CDS             40549..41061
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972574.1"
                     /locus_tag="HMPREF2764_RS10205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_08890"
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_261673659.1"
                     /transl_table=11
                     /translation="MTDLTPETYVGVDNLLQDRKGKAVATFLPDQGSVTTYNQGDILIG
                     NIRPYLKKIWFSNQVGGTSGDVLTIQNSITPCMENKYLYYILSDDRFFYYNVQYSKGSK
                     MPRGDKKAIMQYKFILPSITEQKRIVSTLDNFNTLTNSLSEGLPKEIELRQKQYEYWRE
                     QLLNFTR"
     misc_feature    41075..41093
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.07"
                     /tool="antismash"
ORIGIN
        1 attaggcttg ccttattcca agcatgaatg aattttttca taacaatctc ctttgttgtg
       61 taatgtttat gattatagta taaatatgaa ctaaaatcaa gaattttctg tctattttgg
      121 ctattatttt tgaatattta tggagattca tcacttgtga aagtatggta taataaatga
      181 aaggagtttt ctatgaaaga atttattcaa acctacctca ataagcttga tgttacaacg
      241 attattgaaa atatcttaac caagttaatt tctctgttat tcctattttt actgttttat
      301 atagctaaga aattgctcta taccatggtg cagagaattg ttaaaccttc tctaaaaatg
      361 tctcgtcatg atgttgggcg tcagaaaacc atctcacgtc tgttagaaaa tgtgtttaat
      421 tatacccttt atttcttttt gctttattgt atcttgtcta ttttgggttt gccagtttct
      481 agtttgcttg ctggagctgg gattgctggg gtggctattg gaatgggagc tcaaggtttt
      541 ctgtctgatg tcatcaatgg ctttttcatc ctttttgaac gtcaactgga tgtgggagat
      601 gaggtcgttc tgacaaatgg tcctattact gtctcgggca aggttgtcag tgtcggcatt
      661 cgaacaactc aactcagagg agaagatcag gttctgcact tcgttcccaa tcggaatatc
      721 accgttgtca gcaatttctc tcggacagac caggcctgaa attttagcag atttatggta
      781 caatggaaag agtttggtaa aggagagaag atgtttttag aaaaacagtt gggcaatggt
      841 tgtacctgga ttaacttaga tttggacaag ttgaaaaaac tagaggatct ttctgaaatc
      901 tacggtttgg acaaggaaac catcgaatat gcgctggata ggaatgagcg tgcccacatg
      961 gattatcacc gtgaaacgga gacggtaacc tttatttata atgttcttga tttagaaaaa
     1021 gacaaagaat attatgaagc gattcccatg acctttatcg tcgaaagaca acgaatgatt
     1081 accatcagca accataagaa tgcttatgtc attgatcaga tgtcagctta tctggatagc
     1141 catgagtcgc tttctattta caagtttctc tttgctggtt tagagattat cagtaacgct
     1201 tattatcctg tcattgaaga gatggataaa agtaaggacg aaattagtgc cttgctacgt
     1261 caaactacaa caaagaaaaa tctcttcgcc ctctctgact tggagactgg tatggtttac
     1321 ttgacagcag cagcaaaaca aaatcgactc ctcttggaac atatccaggg ccatgctctt
     1381 tatcggagat ttaatgatgt cgaacgagag cagtttgatg atgccatgat tgaagcccat
     1441 cagttggtgt ctatgacaga cttgatttct caagtcttgc aacaactctc agcttcttac
     1501 aacaacatcc taaacaataa cttgaatgat agtttgtcaa ttttgactat tatctccgtc
     1561 ttactagcag tacttgcggt tattacaggt ttcttcggaa tgaatgttcc tctaccattt
     1621 acagaagagc caaatgcttg gatttatatc ttaatgacta gcttgatttt atgggtggcc
     1681 ttatctcaat ggctgaagaa aattactaga aaataaaaga aaaggagcca aaatggtgat
     1741 tgaaaactac atgccagact ttgctgtgga agcagtctat gatctgacag tcccaagcct
     1801 gcaggcgcat ggaatcaagg ctgttttggt cgatttggac aataccctca ttgcttggaa
     1861 caaccctgac gggacgccag agatgaagca atggctacat gatcttcggg acgcgggcat
     1921 tcgcatcatt gtggtatcaa ataacactaa aaaacgcgtc caacgagcag ttgagaaatt
     1981 tgggattgac tacgtttatt gggctctgaa gcccttcaca tttgggattg accgtgccat
     2041 gaaggaattt cattatgaga aaagtgaagt ggtcatggtt ggcgaccagc tcatgacaga
     2101 tatacgagca gcccaccgtg caggcattcg ctcgatttta gtcaaaccct tggtccaaca
     2161 tgactcgatc aaaacacaga tcaaccgagc tcgtgagcgc cgtgtgaagc gaaaaatcac
     2221 tgaaacgtac ggaccgatta catataaaaa aggaatttaa ctatggaaga aattctctgt
     2281 attggttgtg gagcaaccat tcagacgaca gataaggctg gtcttggttt taccccccag
     2341 tcggcacttg aaaaaggttt ggaaactggc gaagtctatt gccaacgctg tttccgtctc
     2401 cgccactata atgaaatcac ggatgtccag ttgacggacg atgatttcct caagctcttg
     2461 cacgaggtgg gagacagtga tgccttagtg gtcaatgtca ttgatatctt tgattttaat
     2521 ggctctgtca ttccaggctt gccacgtttt gtctcgggca atgatgtcct cttggtggga
     2581 aataaaaaag atatcctacc taagtcagtt aagccgggca agattagcca gtggctcatg
     2641 gaacgtgccc acgaagaagg acttcgtcca gtcgatgtcg tcctaacttc agcacaaaac
     2701 aaacatgcca ttaaggaagt cattgacaag attgaacact accgtaaggg tcgcgatgtc
     2761 tatgtggtcg gtgtgaccaa cgttggaaaa tcaactctaa tcaatgctat tatccaagaa
     2821 atcacgggtg accaaaatgt catcacgact tcgcgcttcc cagggacaac cttggacaag
     2881 attgagattc cgcttgacga cggatcttat atctacgata caccggggat tatccaccgt
     2941 caccagatgg ctcactactt gacagccaaa aacctcaagt atgtcagccc caaaaaggaa
     3001 atcaagccta aaacctatca gcttaatcct gaacaaaccc tgtttctagg cggtctcgga
     3061 cgctttgact ttattgcagg tgaaaagcaa ggtttcacag ccttttttga caatgaactc
     3121 aaattgcatc gtaccaagct agaaggagcc agtgcctttt atgataagca cctcggaact
     3181 ctcctgacac caccaaatag caaggaaaaa gaagattttc ctaaactggt tgagcatcta
     3241 tttaacatca aggataagac agacctagtc atctcaggcc taggatggat tcgtgtaaca
     3301 ggaactgcca aaatcgccgt ctgggcacca gaaggcgtcg cagtcgtcgc acgaaaagca
     3361 attatttaaa ataaaatcac tgagcgaaca aagtgagctc ataaagagat agttattgcc
     3421 gtggggtctt gccaatcgtt agattggcaa ggggcacaat tgagaccaag gctcaattat
     3481 gaggtcagga aatccatttt tcaaagatga gatctttggg aaattagttc cgaccgtccc
     3541 tcaccaccta aaataactat caaaaaacaa ggaagaaaat tatgtcatta acatcaaaac
     3601 aacgtgcctt cctcaacagt caggcacaca ctctcaaacc catcatccaa atcgggaaaa
     3661 atgggcttaa cgaccaaatc aaaaccagcg tccgtcgggc tcttgacgca cgggaattga
     3721 ttaaggttac actcttgcaa aatacagatg aaaacatcca cgaagtagct gaaatcttgg
     3781 aagaagaaat cggtgtggac acagtccaaa aaatcggacg catcttgatt ttgtttaaac
     3841 aatccagcaa aaaagaaaat cgcaagattt ctaaaaaagt caaagaaatc taaaaaacct
     3901 actccaaaca actgttttta cagagaaata aaggagacta gcctatggca atcgaattat
     3961 tgactccctt taccaaggta gagttggagc cagaaataaa ggagaaaaaa cgcaaacaag
     4021 ttgggatttt aggggggaat tttaaccctg ttcacaatgc ccatctgatc gttgcggacc
     4081 aagtacggca acagttggga ttggaccagg ttttgcttat gcctgaatac caacctcctc
     4141 atgtagataa aaaggaaacc attcctgaac accatcgtct caagatgctt gaattggcga
     4201 ttgaggggat tgagggccta gccattgaaa ccatcgagtt agagcgcaag ggcatttcct
     4261 acacttatga caccatgaaa atcttgacag agcaacatcc agatacggat tattacttca
     4321 ttatcggagc tgatatggtg gactatctgc ctaagtggta ccgaattgat gagctggtcg
     4381 atctggttca gtttgtgggg gttcagcgac cacgctacaa ggcagggact tcctatcctg
     4441 ttatctgggt ggatgtgcct ctcatggata tctcgtccag catggtgcgt gatttccttg
     4501 cccaaggtcg aaaacctaac tttctcctac ctcagccggt gctagactac atcgagaagg
     4561 aggggctcta ctgatggctt atcaaaacta tatcaactgc tctcgcgagg ctttgttgga
     4621 aaaaatggca gagcttctac ctgaaaaacg gttaacccat tgtttgggtg tggagcgtgc
     4681 ggccatagaa ttggctcagc gattcgaaat tgatgctgag aaagctggtc ttgcaggtct
     4741 ccttcatgac tatgctaaaa agctgtcaga tcaggaattt ttgaatttga ttaaccgtta
     4801 tcagctagac cttgacctca aaaactgggg taataatgtc tggcatggca tggttggcat
     4861 ctacaagatt caagaagatt tggatttgca tgatccagaa atcctgcgag ccattgaaat
     4921 ccatacagtc ggtgctggtc agatgacaga tcttgataag gttatctacg ttgcagacta
     4981 tatagagcat aatcgtgcct ttcctggagt agatgtagcg cgcgagattg caactctatc
     5041 gcttaataag gcggtggcct acgaaacagc tcgtactgtg gagcatctag ctcatcaggg
     5101 atttccaatc tatcccaaaa cccttgaaac ctataacgcc tttgtgcact atttgaaaga
     5161 ggactaaatg aacgaaaaag aattactaga actagtcgtg aaagcggctg atgagaaacg
     5221 tgcggaggat attctcgcac ttgatgtaca agatttgacc agcgtgacgg actactttgt
     5281 tatcactagc tcgatgaata gccgtcagtt ggacgctatc gctgacaata tccgtgaaaa
     5341 agtagctgaa gcaggcttta aaggaagtca tatcgaaggt gatgcaactg gaggctgggt
     5401 tttgctggac ctaggttctg ttgtcgtgca tatcttctca gaagaaatgc gtgcccacta
     5461 taacctagag aagctatggc atgaggcgaa ttcagtagat atttcagcaa ctcttgctta
     5521 gaagacgaac tcagttgcag tcaactgggt ttctttgctt attttagaaa aaatggatag
     5581 aaaggtaaag ggcgagtggt gtttgccatg gaggctcttg gtatcatgat tatggcaact
     5641 tatgaaacct ttgcggctgt ttacgatgct gtgatggatg atagtttata tgataaatgg
     5701 acggattttt cgctgcgtca tttgcctaag acaaaggata gaaagaagct tttggaattg
     5761 gcttgtggaa caggtatcca gtctgtccgc ttttctcagg ctggctttga tgtgactgga
     5821 cttgacttga gcgcggatat gctgaagatt gctgaaaaga gagcggcttc agccaagcaa
     5881 aagattgatt ttattgaagg caatatgctg gatttgtcca aggcaggtca atatgatttt
     5941 gtcacgtgtt attctgactc aatctgctac atgcaggatg aggtggaagt aggggacgtc
     6001 tttaaagaag tctataatgc cctcaatgaa gatggagttt tcatctttga tgtgcattcg
     6061 acctaccaaa cagacgagat cttcccaggc tattcttacc atgaaaatgc ggaagatttc
     6121 gctatgctct gggacaccta tgaggacgaa gctcctcatt ccatcgtcca tgagctgact
     6181 ttctttatca aggaggcgga tggttccttt agtcgccacg atgaagtgca tgaggagcgg
     6241 acctatgaga tcttgaccta tgatattttg ctggaacagg ccggattcaa atccttcaaa
     6301 ctctttgcgg actttgaaga caaagagccg acagaaacta gcacccgttg gttttttgtc
     6361 gcgcagaagt aggaggttga tatggttcga tcaaaatatt cttgggaaga agtttctcag
     6421 tttaatcgta tccgtcaaaa tggaacgctt tgggaaaaag atgggcaata cttttatgtt
     6481 caggaagaag gaaccgtatt ttcagagtta gttgtttacg atatgtccaa gaaacttttt
     6541 gatatgttag taaatgaaat aaaatcagag gatgatatcc gacatatgct aatgtacgga
     6601 acatggccaa tgacggttgc cggatgccat agtccaacta tgttgatagc ttatcctgaa
     6661 ctacaaaaga attatagtaa tgaacaacta gcagagatcc ttccagtggg agaaaaacaa
     6721 tggcttaact ggagagggag attgcctgag tggtatcgta gatttcgtca ttaggaaggg
     6781 agattaccat gaccatcaca ggtattatcg cggaattcaa tccctttcat aatggacata
     6841 aatacctgtt ggatcaggcg aagggactga aaatcgtagc catgtcagga aatttcatgc
     6901 agcgtggaga gccagctatc gtggacaagt ggacacgggc ccagatggcg ctggaaaatg
     6961 gagcggatct ggtagtagaa ttgccctttt tagtcagtgt tcaggcggca gatttctttg
     7021 gccaaggcgc tgtgtatatc ttggctcggt tgggtattga tactctagca tttgggacgg
     7081 aggaagttgt ggattaccag aaaatcgctg acttatacac agaacaaggc gctgatatgg
     7141 agaaatttgt ggaaaatctt cctgattctc tttcttatcc ccagaagacc caggccatgt
     7201 ggaaggaatt tgcaggtctt gatttttcag gaaatacgcc caaccatgtt cttgctcttg
     7261 cctatgtcaa ggcagttgcg ggactcaaca tcaaacttca tccgattcag cgtcaggggg
     7321 ctggctatca ttctgtggat aaggatgtgg actttgcctc ggcgacagcc ctgcgtcagc
     7381 accagaagga ccaagatttc ttagaacgct ttatgccttc ggttgccctt tttgagcagg
     7441 ccagtaaggt gaactgggaa gactattttc ctatgctccg ctatcaaatc ttgtccaatc
     7501 cagacctaac cactatctat caggtcaatc aagaaatggc tgtgcgcatt aaggaagcca
     7561 tcaaaacagc tcagtcttta gaagaattgg tcgaggcggt tgccaccaaa cgttacacta
     7621 aggcgcgtgt cagacgtctc ctgacttata ttttggtgca ggccagagaa agtgacttgc
     7681 cagaagggat tcatgttctt ggttttaccg aaaaaggcag acaacatctc aaatctctga
     7741 aagggcaggt acatttagtc agccgcatag gtaaagagcc ttgggatagc atgacgcaaa
     7801 aggcagacca gatttatcaa cttggaaatc caggtatagc ggagcagaat tttggaagag
     7861 tgccgattag aatagaaaca aactaagtct actgaaaggt aggctttttc ttaaatctct
     7921 actaaactag gatttctaag aaatagagat tgcactaata aattttaggt aaatgtgttt
     7981 taaattccca aaacatattc tattttaggt ttgtgaaaat cactttttta tggtagaatg
     8041 taaaagaatg tatgtcattc ggaataacaa taaaatgagg taaaaacatg gaaatcatgt
     8101 cgcttgcgat tgctgttttt gccgtcatca ttggtttagt cattggatat gtcagcatct
     8161 cagccaagat gaaatcatct caggaagctg cagagttgat gcttttaaat gctgaacaag
     8221 aagcaactaa tttacgtgga caagctgagc gtgaagcaga tttacttgtt aatgaagcta
     8281 aacgtgaaag caagtctctt aaaaaagaag cactattgga ggccaaagaa gaagccagaa
     8341 aataccgtga agaagtggac gctgaattca aatcagaacg tcaagaactc aaacaaatcg
     8401 aaagtcgttt gacagagaga gctactagcc tcgatcgtaa ggacgacaat ttgacgagta
     8461 aagaacaaac acttgaacaa aaagaacaaa gtatttctga tagagcgaaa aaccttgatg
     8521 cgcgtgaaga gcaattagag gaagtcgaaa gacaaaaaga agcagaacta gagcgtattg
     8581 gtgctctgtc tcaggcagaa gcacgagata ttatcttggc tcagacagag gaaaacttga
     8641 ccaaggagat tgctagccgt attcgcgaag ctgagcaaga ggtcaaggaa cgttctgata
     8701 aaatggccaa ggatatcctg gttcaagcta tgcaacgtat cgctggtgaa tatgtagcgg
     8761 agtcaacaaa ctcaacagtt catctgccag acgatactat gaagggacgc attattggtc
     8821 gtgaaggtcg taacattcgt acctttgaaa gtttgacagg ggtcgatgtg attatcgacg
     8881 atacaccaga agtggtaacc ttgtcaggat ttgacccgat tcgtcgtgaa attgctcgta
     8941 tgaccatgga aatgttgctt aaggatggtc gtatccatcc agctcgtatc gaagagttgg
     9001 ttgagaaaaa ccgtcaagag attgataata agatccgtga atatggtgag gcagcagcct
     9061 atgagattgg tgcgccaaac cttcatccag acttgatgaa gattatggga cgtttgcagt
     9121 tccgtacttc ttatggacaa aatgtcttgc gtcattcgat tgaggttgct aagttggctg
     9181 gtattatggc gagcgaactt ggtgaaaatg cggctcttgc ccgtcgtgct ggattccttc
     9241 acgatatcgg aaaagctatt gaccgcgagg ttgagggtag ccacgttgaa atcggtatgg
     9301 aattggctcg taagtataag gaacacccag ttgtggtcaa tacgattgct agtcaccacg
     9361 gtgatgttga agctgagagc gtcattgcag tgatcgtcgc tgcagcagat gccttgagcg
     9421 cagctcgtcc aggtgctcgt agtgagtctc ttgaaagcta catcaagcgt ctccatgatt
     9481 tggaagaaat tgctaacggc tttgaagggg tacaaaatag ctttgccctt caagcaggac
     9541 gtgaaatccg tatcatggtc aacccaggac aaatcaagga cgacaaagtc acaatcttgg
     9601 ctcacaaagt tcgtgagaaa attgaaaaca atctcgatta cccaggaaat atcaaggtaa
     9661 ccgtgattcg cgagcttcgt gcagtagatt atgctaaata aataagaaag agcagttgaa
     9721 aaattactgc ttttttgtta cactagatag aaagactgta aaggataatc tggctttttg
     9781 ccattattct agagaaatgt tatttcacag actgactaaa aggagacaca atggtagacc
     9841 gaggcttact aatcgttttt tctggtcctt caggggttgg aaaaggaacg gttagaagag
     9901 agatttttga gagttctgaa aatcaatttc aatattctgt atcgatgacg acacgcgcac
     9961 aacgtcctgg tgaagtggac ggagtggact atttcttccg tactcgtgaa gagtttgaag
    10021 agctgattcg tcaaggacag atgttggaat acgcagaata tgtcggcaac tactatggaa
    10081 ctcctctgac ctatgtcaat gaaaccttgg acaagggaat cgatgttttc cttgaaattg
    10141 aagttcaggg tgctcttcag gtcaagaaaa aggttccaga tgctgtcttt atcttcctga
    10201 caccaccaga tttggatgaa ttgcaagatc gtttggtagg acgtggaaca gacagcgcag
    10261 aagtgattgc ccaacgaatc gaaaaagcca aggaagaaat tgcccttatg cgtgagtatg
    10321 attatgcgat tgtcaacgat caggtgcccc tagctgctga tcgtgtcaaa cgtgtgatcg
    10381 aagcagagca cttccgtgtg gatcgtgtca ttggtcacta tcaggagatg ttaccaaaat
    10441 ctccaactac ccgataaaat ttagaaaata ggtacaagca aatgatgtta aaaccctcta
    10501 ttgatacctt gctcgacaag gttccatcaa aatattcact cgtaatcttg gaagcaaaac
    10561 gtgcccacga attggaagca ggtgcgccag caactcaagg tttcaaatct gaaaaatcaa
    10621 ctcttcgcgc tttagaagaa atcgaatcag gaaacgttac aattcaccca gatccagaag
    10681 gaaaacgtga agcagtgcgt cgccgtatcg aagaagaaaa acgccgcaaa gaagaagaaa
    10741 agaaaatcaa agagcaaatc gctaaagaaa aagaagatgg tgaaaaaatt taaggttggg
    10801 gggactcaat cttatttttt ctattgcaag aatgtactga caaggaggag gtgagaagat
    10861 ggctatagcc aagattatcg tagatgtgcc tttgatgcag acggaccagc cctatagtta
    10921 caggattcct aaggaattcg agggaatgct agaagttggg atgcgggttc atgtgccttt
    10981 tggtaagggc aatcgcctga ttcaagggat tgttcttggt ttggagtccc aaccagatga
    11041 agaagaggct aatcatgatt taaaagatat tgcggaggtg ctggattttt ctcctgttct
    11101 cacgcaagaa caactctggc ttgctgagga gttacgcaag tccgtcttct cctataaaat
    11161 ctccatcctc aaggctatgc taccaggatt tctgaactcc agctatgaca agattctcta
    11221 tcctcttgca ggtctgagtc aggaagaccg agagcgcttg tttggttcag aggattcgct
    11281 tgcattttct tctctggatt tagctaagca agctgaaatg atgcgtttga ctagaaaagg
    11341 cctgcttggt ctagaatatc aggcaattga tcaaaagaag gtcaagaccc agtcttggta
    11401 tgaggttgac cttgctcaat tagaaagtgt agagatttct acgcgtgcta agaaaaagtt
    11461 ggaattgaga gattatttgc tgtctcatcc agagagtgct tctttggcta gtttgttaga
    11521 gtcctactcg cgggagcaag tcaacttctt tgtggaacaa ggtgctgtga ccatagtcca
    11581 aaaggaagtt caacgctcgg ctgcttattt tgaagggatt gaagcaagtc agcctttgga
    11641 attgaatcca gagcaaagac aggcgcgtga tgcggttgtc agtgcgattg gcagtcatca
    11701 ggctcccttc ctccttcaag ggattacagg aagtgggaag accgaggttt acttgcagat
    11761 tatccaaggg gctttggata agggcaagac agctattttg ctggtacctg agatttcctt
    11821 gactcctcag atgacggagc gttttatcgc tcgttttggg gataaggttg ccattcttca
    11881 ctctggcctg tctaatggtg aaaagtatga tgaatggcgc aaggtggaac gcggcgatgc
    11941 tcaagttgtt gttggtgcta gatcggccat ctttgccccc ctgaaaaatc taggtgtcat
    12001 gattattgat gaggagcatg aagcgactta taagcaagac agcaatcccc gttaccatgc
    12061 cagagaggtg gctattttac gggcccggta taatcaagcg gccttggtcc ttggttcagc
    12121 gacaccaagt ctggaaagcc gtgcgcgggc tggaaaaggc gtctatcagc acttatgtct
    12181 gacccaacga gctaatcctt tagccaccat tcctgaggtt caagtgattg attttcggga
    12241 ctatatcgga caaaatgaga cgtcaaactt tacaccgcct ttgctagaag ctatccaaga
    12301 ccgtctggct aaaaaagagc aggtggttct catgctcaat cgccgtggtt attctagctt
    12361 tgtcatgtgt cgggaatgtg ggacggtgga tacttgtccc aactgtgaca tttctctgac
    12421 cttgcacatg gataccaaga ccatgaactg ccattattgt gggttttcta aggacattcc
    12481 tcaggtctgt cctaactgta agagtcgcag tattcgttac tatggaacag ggactcaaaa
    12541 agcttatgat gagctagcag aactctttcc tcaagcccgc attctgcgta tggatgtgga
    12601 tacgacccgc aagaaaggca gtcaccaagc tcttcttgat cagtttggac gaggagaagc
    12661 agatatcttg ctgggaactc aaatgattgc caagggattg gattttccca atgtaaccct
    12721 agtcggagtt cttaatgcgg atacagcttt gaatctgcct gatttccgtt cttctgagag
    12781 aaccttccag ctcttgactc aggtggcagg tcgagcaggt cgggctgaaa aagctgggca
    12841 ggtcttgatt cagtcttaca atcctcagca ctacgctatt cgatttgcaa aagaccaaga
    12901 ctacgaaggc ttttatgcct atgaaatggg tatcagacgc caacttggtt atccacctta
    12961 ctatttcacg attggcatta ccctctctca taagaaagaa gaagaggtgg tcaaacgtgc
    13021 ctatgaagtt atgagcgttt tgcggtcagg tttgtcagag accagtaaga ttctcgggcc
    13081 gacgcccaag cccattgctc gtacccacaa cctctatcat taccagattt tgattaaata
    13141 tcgtttagaa gatgagctgg ggccaaccct caatcgggtt ctggctttaa ctcaagaacg
    13201 ggaaaatagt gagctccgtc ttagcattga ccatgagcca cagcaatttt tataagaagg
    13261 agaagatatg acaaaactaa tctttatggg gacacccgac ttttcagcaa cagtcttaaa
    13321 aggacttttg acagatgacc gttacgaaat tctagccgtt gtaacccagc cagaccgtgc
    13381 tgttggtcgt aaaaaagtta tccaagaaac accagtcaag caggctgcca aggaagcagg
    13441 tcttcctatc taccaacctg aaaaattatc tggaagtcca gagatggaag cgattatgaa
    13501 tttgggagcg gatggaattg tgactgctgc ttttgggcag tttctcccaa gtaaactcct
    13561 tgatagcatg gactttgcgg tcaacgttca tgcctctctt cttcctaaac accgtggtgg
    13621 tgcgcctatc cattatgcct tgattcaagg ggatgaggaa gctggtgtga ccattatgga
    13681 gatggttaag gaaatggatg caggagatat gatttctcgt cgtagtattc cgattacgga
    13741 tgaggacaat gtcggcacct tgtttgagaa attggcgcta gttggtcgcg atttgctttt
    13801 agacactttg tctgcctaca ttgctgggga aatcaaacct gaaccgcagg atccaagtca
    13861 agttactttc tcgcccaata tcaagccaga ggaagaaaag ttagattgga ctaaaagcaa
    13921 tcgtcaactc tttaaccaaa tccgtggaat gaatccgtgg cctgttgccc atactttcct
    13981 taagggcgac cgctttaaga tttatgaagc actactagtg gaaggtaagg gaaatccagg
    14041 tgagatcctc tctattggta agaaagaatt gattgtcgca acggcagaag gggctctatc
    14101 cctcaaacaa gtgcagccag ctggtaaacc taagatggac attgcttcct tcctcaacgg
    14161 acttggacgg acattgactg taggagaacg atttggtgac taaagtagaa acggctagaa
    14221 gtttagctct agcagcatta gaggatgttt ttatcaatca agcatactca aacatcgcct
    14281 taaataagca tctaaaggga agtcaacttt cagcagcaga caagggcttg gtgacagaga
    14341 ttgtctatgg aacggtggcc cgtaaactga ctctggaatg gtacctgtcc cactttatcg
    14401 aagacagaga ccagttagac agctggctct atgtcctact tctcatgagc gcctaccagc
    14461 tccgctattt gaacaagatt ccagaccatg ctgtggtcaa tgaagcagta gaattggcca
    14521 aagtccgtaa aaaaggtagt gaaaaattgg ccaacgccgt ccttcgtcgt attctacgtg
    14581 aaggatggcc agatatcacc agcatcaaac gaaaaaacaa gcgtgactcc attgcatatt
    14641 cccttccggt ttggctagtt tccaagctca aagaagaata cggcgaagag cgagcgcagg
    14701 ctatttttga aagtctcttg gtgcgtaaca aggccagtat tcgtgtgact gatttaagcc
    14761 gaaaagagga aatccaagcc ttgttggagg ctagtgattc gtccttgtct tcttctggtc
    14821 tggttaagga gcaggggcat tttgcaggcc atgatttgtt tgcagaggga gccattacca
    14881 tccaagacga gtccagtcag ctggttgcgc caactcttga tttacaaggt gatgagaagg
    14941 ttctagatgc ttgtgcggct ccgggtggga aaacagccca tatagcctct tatctcacga
    15001 caggtcaggt tactgctctg gatttatatg accataagtt ggacttaatc caagaaaatg
    15061 cccaacgtct aggagttgca gatcgggttc aaaggcaaaa attagatgcc agaaaggtgc
    15121 atgagttttt tggtcaggat tcctttgaca agattttagt agatgctccc tgttcaggaa
    15181 ttggccttct gcgtcgaaaa ccagacatca aatacaataa agaaacggca gatttcgcgt
    15241 cattgcagga aattcagcta gaaatattag gtagtgtttg tcaaacacta cgcaaaggtg
    15301 gtataataac ttatagtacc tgtactattg tctcagagga gaattttcaa gtcgttgagg
    15361 cgtttttaga aagtcatcct gagttcgagc aggtagaact agaacatgaa tgtaaggata
    15421 tcatgaaaga cggctgtatc ctcattacac ctgaattgta tggaagtgat ggattcttca
    15481 tcagtcaatt tcgcaagata tcggattagg aaggaactga cacatggaaa tttcattatt
    15541 aacagatgtt ggtcagaaac gaacaaataa ccaagactat gtcaaccact atgtcaatag
    15601 agctgggcgt accatgatta ttttagctga tgggatggga ggtcatcgcg cagggaatat
    15661 cgctagtgaa atggcggtaa cagacctagg tatagcttgg gttgacaccc agatcgatac
    15721 agtcaatgaa gtgcgtgaat ggttcgccaa ttacctagaa attgaaaatc aaaagattca
    15781 tcaacttgga caagatgatg cctataaagg aatgggaaca actctagaag ctgttgctat
    15841 tattggcaat caggctatct atgctcatat tggagattct cgtatcggtt tgattcgtgg
    15901 agaagagtac caccagttga cgagcgacca ttctttggtc aatgaattgc ttaaggcagg
    15961 tcaattgaca ccagaagaag cagctagcca tccacagaaa aatattatta ctcaatctat
    16021 cggtcaaaaa gatgaagttc aacctgattt tggaatgatt acccttgagc caggagacta
    16081 tctcttgctc aatagtgatg gtttgactaa catgatttca ggcagtgaga tttgtgatat
    16141 tgtaaccagt gatattcctt tggcagataa aacagcgacg cttgtgcgtt ttgctaacaa
    16201 tgcaggaggt ttagacaaca ttacggttgc ccttgtttct atgaacgagg aggatgcaga
    16261 atgatccaaa tcggcaagat ttttgccgga cgctatcgga ttgtgaaaca gattggccga
    16321 ggaggcatgg cagatgtcta tttggccaag gatttaattc tagacggaga agaagtggca
    16381 gtgaaggtcc tgaggaccaa ctaccagacg gacccgatag ctgtagctcg ttttcagcgt
    16441 gaagcgagag ctatggcaga tctagaccat cctcatatcg ttcggataac agatattggt
    16501 gaggaagacg gtcaacagta tcttgcaatg gagtatgttg ctggactaga cctcaaacgc
    16561 tatatcaagg aacactatcc tctttctaat gaagaagccg tccgtatcat ggggcaaatc
    16621 ctcctagcca tgcgtttggc ccatactaga ggaattgttc acagggactt gaaacctcaa
    16681 aatatccttt tgacaccaga tgggactgcc aaggtcacag actttgggat tgcggtcgct
    16741 tttgcagaga caagtctgac tcagactaac tctatgctgg gttcggttca ttacttgtca
    16801 ccagagcagg cgcgtggttc taaggcgact gtacagagtg atatctatgc catggggatt
    16861 attttctatg agatgctgac aggccatatc ccttatgacg gggatagtgc ggtgaccatc
    16921 gcccttcagc atttccagaa accactgccg tcagttattg atgaaaatcc atctgtgcct
    16981 caggctttgg agaatgttgt tatcaaggca actgccaaga aattgacaga tcgttatcag
    17041 tcagttgcag agatgtatgt ggacttgtct agtagcttgt cttataatcg tcgcaatgag
    17101 cctaaactgg tatttaatga tactactaag gcggacacca agacactacc gaaggtatcc
    17161 cagagtacct tgacttcgat tcctaaggtg caaacacaga gtccgaagcc acagactgcg
    17221 aaacctagtc agcaggtttc agaagacaat tacgcaagca agactgttaa gaaacggaaa
    17281 tttagagttc gttatatgat tttgttggcc agcattgtat tggtggcagc ctctctgatt
    17341 tggatactat ctagaactcc tgcaaccatt gccattccag atgtggcagg ccagacagtt
    17401 gcggaagcca aggaaacgct caagaaagcc aattttgaga ttggcgagga gaaatcagag
    17461 gctagtgaaa aggtggaaga agggcggatt atccgtacag atcctgaagc tggaaagact
    17521 cgaaaagaag gttcgaaaat caatttggtt gtctcatcag gcaagcaatc tttccaattg
    17581 agtaactata tcggccgtaa atcgacagat gttatcgcag aactcaagca gaagaaggtt
    17641 cctgaaaatc tcatcaagat tgaggaagaa gaatcaagtg agagtgaagc aggaaccgtt
    17701 ctcagacaga gtccagctgc cggaacaacc tatgatttga gcaaggcctc aacaattacc
    17761 ttaaccgttg ctaagaaagt aaccagcgtt gctatgccaa gttatatagg atctagtctt
    17821 gaatttacta aaaataatct cgttcaaatt gttgggatta aagaagccaa tattgaagtt
    17881 gtagaagtgt cgacagctcc tgatggaact gctgagggga ctgttgtaga gcaaagtcca
    17941 aaagcaggcg aaaaggttga tttgactaag acgcgtgtca agatttcaat ctacaaacca
    18001 aaaacaccac cgtcaacgtc atcatcagca ccagcccaac gtggaaacca aggttctact
    18061 acgacaccaa gtcaggggaa ccaacaagga aatcaacgag ggaatgcacc tgctactact
    18121 caatcaagta gtgaaggcaa ccacgaaaat tctcgtgatt aaacgaatct ttgtcatgat
    18181 ttcatggcaa agattttttt tgagtccgga tttgtgatag aatagaggaa gttgataaaa
    18241 ggaggaacgc atggaagaat caagagaatt aaatgccgtc atcgatgtga ttatgttagc
    18301 tggaaccatt cttctcaaaa gtggctcaga gattcatcgt gtagaagata ccatgatccg
    18361 tattgcgcat tcgcagggga ttgtggattg caatgttctt gccatgcctg ctgctatctt
    18421 tttctccatt gaaaatacca atatttcgcg aatgaaacgc gtgacttcct cttcttataa
    18481 tattgaaaaa gtctgtgatg tgaaccagat ttctcgtcag ttggtaggag gaaatcttga
    18541 tttagagaca gccttcaagc aattgacggc tttgcaagac cagccccttc cttatactaa
    18601 gttgcaggta actctggctg cgacctttag cgcccctttc ttttcgatta tgtttagtgg
    18661 aaatatctac gacgcacttg gggcaggagt ggctacctta tttggttttg ccttttccct
    18721 ctatgtggag aagtttatcc gaattccctt tgtaacggcc tttgctggag cctttgtctt
    18781 tgggatgatt gcccagtttt gggctcgcta cacaggtttt ccttcaacgg cagatttgat
    18841 tatagctggt gcggtcatgc cgtttgtacc agggattgcc ttgaccaatg cggttcgtga
    18901 tattatgacc aaccacataa actctggtat gagtaagatg tttgaatccc tgctcattac
    18961 ccttgcttta ggggcgggaa cttctgtcgc cttggtattg atgaattaat atgacactaa
    19021 caaccttttt attacaagca gtagcaagtc ttcttgctat catcactttt ttaatcgtac
    19081 tcaatgttca acgttctatg ctcttaccag gaggaatttt gggcatggct gtctggctaa
    19141 tttatctttt gctcaaggaa ccgaccaatg ttattgtggc tacttttatt gcagccatta
    19201 tcggttcttg cgtcagccag attttaagta ttctttataa gacacctgct gtggtcttta
    19261 tcttggccat cttagcacct ctggttccgg gttatctctc ctatcggaca actgcctttt
    19321 ttgtgacggg agattacagt catgccattg ctagtgcaac cttggttgtt atgttggctt
    19381 tggtgatttc cattggaatg gctagtggaa cagtgattct cagactgtat cattatataa
    19441 aaacacattg agcattggag aatttacaga aataaaagaa ttttctgaaa aatgagacaa
    19501 atgcattgac aacgctttct ctatgtagta ttctatatat agaaaggagg aaaaatcatg
    19561 aaaaaattac tattttcctt attgtttgta agtctactga ctttattgtt tatcccagtc
    19621 atggtttcta gttcgagctc agagtttcaa agtggattgc aagagaatca gttgattgct
    19681 gagaaggtta gtaaaacact tgacaagaca tttgataaga atatcagaga aattccgact
    19741 agtcagtttt atcaagaatt tgtagatgag atgggaagga cttactcagg aaatttaatc
    19801 ctccaggaac tgctaactga gaatggggct tataaagcta cttatgttgg tgaactctat
    19861 agcaactaat cattatttaa aactgtgacg aataagcgac ttgatttggt gaatcaagtc
    19921 ttttttctct cttttactgc tatttgtgat aaaatagtat agaacgattt tttacaatga
    19981 atgataaaac agaggtaaat atgacaatcg gtattgataa gattggtttt gcgaccagtc
    20041 aatatgtctt gaaattacaa gacttagcag aagcgagggg aattgaccct gaaaaattaa
    20101 gcaaaggact cttgctcaag gaattgagta ttgcgcctct aactgaggat atcgtgactt
    20161 tggcagctag tgcaagtgat tctattttaa ctgagcaaga aagacaagaa atcgatatgg
    20221 tcattgtggc gactgagtca ggaattgacc aaagtaaagc tgcggccgtc tttgtgcatg
    20281 gtttgctggg catccagccc tttgcgcgta gtttcgagat taaagaagcc tgctatggag
    20341 cgacagctgc cctccattat gccaaattgc atgtggaaaa ttctccagag tccaaggttt
    20401 tagtcattgc cagtgatatt gccaaatacg gtattgaaac tccaggagaa ccaactcaag
    20461 gtgctggaag tgtagctatg ttgattacac agaatccacg cattatggcc tttaataatg
    20521 acaatgtggc tcagactcgt gacatcatgg atttctggcg tccaaattac tcgacaacgc
    20581 cttatgtaaa tggtgtctat tctacccaac aatatctaga tagtttgaaa acgacttggc
    20641 ttgaatacca aaaacgctac cagcttactt tggatgattt tgcggcggtt tgcttccact
    20701 tgccttatcc taaattagcg ctaaaaggct tgaaaaaaat catggataag agcctggctc
    20761 aagagaaaaa agatctcttg caaaagcatt ttgaccagtc tattctctac agtcagaagg
    20821 tggggaacat ctacacagga tccctcttcc ttggactctt gtctctcttg gaaaatacag
    20881 atagcttgaa ggctggggat aaaattgccc tttatagtta cggaagtggg gctgtggctg
    20941 agttctttag tggtgaattg gttgaaggat atgaagctta tctggataaa gaccgcttga
    21001 acaagctcaa ccaacgaact gccctatccg ttgcagacta tgaaaaagtc ttctttgagg
    21061 aagtagactt agatgaaaca aattctgccc agtttgctgg ctatgaaaat caagattttg
    21121 ccttggttga aattgttgac caccaacgcc gttatagcaa ggttgaaaaa taatgaagat
    21181 aagttggaat ggattttcta aaaaatcata ccaagagcgc ctcgagctgt taaaagctca
    21241 ggcgctcctt agtcctgaga gacaagcgag tctggagcag gatgaacaga tgagtgtgac
    21301 tgtggcagac cagctgagtg agaatgtagt gggaactttt tctctgcctt attcgctggt
    21361 cccagaggtt ctcgttaacg gtcaggaata cacagttccc tatgtgacag aagagccctc
    21421 agtggttgct gcggccagct atgcaagtaa aatcatcaag cgagcaggtg gctttactgc
    21481 tcaggttcat gagcgccaga tgattgggca ggtagccctt tatcaagttg ctgatccaga
    21541 tttagtgcaa gagaagattg acggcaagaa agtagaactc ttggaacttg ccaatcaagc
    21601 ttatccttct atcgttaaac gcgggggtgg ggcgcgtgat ttgcatgtag agaagatcaa
    21661 agctgaaaca gactttctcg ttgtttatct ccatgtagat acccaggaag ccatgggtgc
    21721 taatatgctc aataccatgc tggaggcctt gaaaccagtc ttagaagaac tcagtcaggg
    21781 acagagtctc atgggaatcc tatctaatta cgcgaccgat tctctggtga cagcaaactg
    21841 tcgcatcgcc tttcgctatt tgagccgtca aacggatcaa gggcgagaga ttgcggagaa
    21901 aatagctttg gctagccagt ttgcgcaggc tgatccttat cgagcagcta cccataataa
    21961 aggaattttt aatggtattg atgccatttt gattgccact ggtaatgact ggcgtgccat
    22021 cgaagccggg gctcatgtct ttgccagtcg agatggacat taccaaggtc ttagtcaatg
    22081 gacgctggac cttgaaagag aagaattggt tggtgagatg accctgccca tgcctgtagc
    22141 gaccaagggt ggctctatcg gccttaaccc tcgtgtagcc ctcagtcacg aactactggg
    22201 aaatccttct gccaaagaat tagcccagat tatagtgtct atcgggcttg cccaaaattt
    22261 tgctgccctc aaagccttgg tgagtacagg gatacagcaa ggacacatga aattgcaggc
    22321 caaatcctta tctctcctag caggtgctag tgaatccgag gtagctcccc ttgttgagct
    22381 cctcattgca gataaaacct ttaatctaga gacagcccag cgttatctag aaaacttaag
    22441 atcataaaaa actcagaccg atcggtctga gttttcttgt gtttatactc ttcgaaaatc
    22501 aaattcaaac cacgtcnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    22561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntagt
    22621 ttgctctttg attttcattg agtattaaat actttttcct ggtaaaagag taactggtaa
    22681 aaagtaacca gttgtcgcga cttccttacc tgcgatcttc tgcaagagga ggtcaacagt
    22741 gaggcaggca atctcttcca agggttgctt gatagtagcc agttgagggt agtaattttc
    22801 gataaagtag gtaccatcat agccaatgac tttaagctct tctgggacag aaatgcccag
    22861 ttcttgagca attttaatga ctagaatagc tgtcaaatca tccgaagcaa aaatggcatc
    22921 tggtttttga tgggtcaaga tattcttgat ttccatttct tttctgacag gagaaaagtc
    22981 actggaaaca ttgataatag gtgcttttgg gagtacagat gcaaagccag cgtggcgcag
    23041 tccagtaggc gaattggaat tgtcattccc tgtaatcatg atgatagact gggcgcctgt
    23101 tttaaccaag gtctgggcgg ctaggagccc accagcatag ttgtcagagg aaacgactgg
    23161 aatgtctggc gataggttgc ggtcaaagga aataatcggc gctgtcacgc gattgtagtc
    23221 ttcgattccc aagttgtgac taccagaaat gatgccgtct acctgattgg cttccaacat
    23281 ttcgatgtat tcacgttcct tttcagagtc gtgttcgctg ttgcagatga tggtcttgta
    23341 accattttta aagagttggt gttccagctt atcaatcaat tctgcataga aaacgttgga
    23401 aatattgggg aaaatcaagc cgattaactt agctgatttt ccttgtagac tgcgagctag
    23461 gttgttgggt ttatagccca attctcgcat ggcttcatta accttttgaa tggttttctc
    23521 agagagataa ccttttttat ttataacccg agagacggta gtggggctga cgcctgcaag
    23581 tttggcaaca tcagttagtt ttgcgaccat aatctaattc atagtaagtt ccagttgggt
    23641 ttccagattt gatgaggatc ccattttggt ccgcatgtgg gaagacacga ccagaaaata
    23701 ctttttctcc tttattgatg aaaatttcaa agacagagtt atcgatgaaa atcgtagcag
    23761 tagtagcctg attctcgata gggcaagaac gagttgttcc aaagtcttgg gcatactgtt
    23821 caccagcctg gctacgatct actgttactt gaccatttac aaggtcaaag ttgatggaaa
    23881 gtcccttgcc ttcttgatca gcaagtaaga caatctcgct ctggctatta gcttccaagc
    23941 tgagttcaag ttcgtaagtg ttattggttt gagcacgatt cgagaaggct tcttcagagg
    24001 cacgaaggtc cttgacagct gcgactggat attggtagag tttaccgtct ttgatagtca
    24061 gttctttgac caaagagaag attccttggt ggtcaaaatg gtcagatgga tatgaaacat
    24121 caggcaagcc aagccagcta acagctagag cgcgtccatc aggagcgttg aaggcttgag
    24181 ttgcataggc ttcgaaacca tagtccatgt tttgaagttg agatacatct accattttag
    24241 cattttcagg atcaaaggaa gccccaatct tatacatatt tggatagata ttatcgtagt
    24301 ctagaacttt cttatccaat ccttgtgggc agtagagaag tacaggttgt tcccctacaa
    24361 agaccagatt aggacattcc atcatgtagg cagtacggtc gttagcaaag tcaaggttgc
    24421 caacggcttg ccagcttgta tagtcgttgt ctacagactt gtagagacgg acgaagcctt
    24481 ttttctccaa gtcctgtcca ccgacgatag catagtattg tcccttgaag ttaaaaattt
    24541 gcggatcacg gaagtggtca gtagagtctg ctggctggtc gatcaagatc ttgtcgatct
    24601 tcgtaatctt gccatccttg tccatcaaag caccgatttg gtacgggtga cggatccagt
    24661 tttcatcgcg gacatttcct gtatagaata ggaataactg atcaccaaat tgcatagcag
    24721 aaccagagta ggcgccgtgg ctatctaatg gagtatcagg caaaactttg actccagttt
    24781 ctgtgaaatg aaccaagtcc tcgctttcca attgcaccca agatttcaaa ccgtgggctg
    24841 caccaaaagg aaagttctga taaaaaacaa tccactttcc atcaaagtaa gaaaagccat
    24901 ttgggtcgtt taggagtcct gtttttggct caacgtggta atgagtatgc catggagatt
    24961 gtgccatatt ttccttaata ttcttaattt cttcttgcgt ccagtcttga taaagtctgt
    25021 aacgacgctc agtagtccat ttcattcttt cattcctcca aaaatcttat cacttttaat
    25081 agtaaccgtt ttcggaaaaa aaagcaagcc ttttatgtta aaaaagagaa aaactgtcaa
    25141 acgtttgtca caaaataaat gcagggaatc aatcaaattt ttaggaaaat atgaaagata
    25201 atgaaacaaa acccttttaa ccaagatttt aaacttattt tttcaaggaa tatctgataa
    25261 aacaatcaaa agcaatcaat ctaaatcgtg cccactaagt ggatagaata ttttttctgc
    25321 aaaacgcttg acatatttct aaaacatgat aaaataatag tcgtaagggc gaataaaatc
    25381 gctttcatac aagaataaat tttttataag gagatttttg caaatgaaca atcaggaaat
    25441 tgcaaaaaaa gtcatcgatg ccttgggcgg acgtgagaat gttaacagtg tagctcactg
    25501 tgcaactcgc ctccgtgtta tggtaaaaga tgaaggaaaa atcaataaag aagtgattga
    25561 gaacttggaa aaagttcaag gtgctttctt taactcaggt caataccaaa tcatctttgg
    25621 tactggtaca gttaacaaaa tgtacgatga agttgttgcg cttggtttgc caacatcatc
    25681 taaagatgac atgaaagcag aagctgccaa acaagggaac tggttccaac gtgctatccg
    25741 tactttcggt gacgttttcg ttccaatcat cccagttatc gtagcgacag gtcttttcat
    25801 gggtgtgcgt ggtcttttca acgctcttga aatgccactt ccaggtgact ttgcaactta
    25861 cacacaaatc ttgacagata cagccttcat catcttgcca ggtttggttg tgtggtcaac
    25921 cttccgtgta tttggtggaa atccagctgt tggtatcgtt cttggtatga tgcttgtttc
    25981 tggctcactt ccaaacgctt gggcagttgc tcaaggtggt gaagtaactg ctatgaactt
    26041 ctttggtttt atccctgttg ttggtttgca aggttccgtt cttccagcct tcatcatcgg
    26101 ggttgtcgga gctaaatttg aaaaagctgt ccgcaaggtt gttccagatg tgattgacct
    26161 cttggtaaca ccattcgtga cacttttggt catgtctatc cttggactct ttgtcattgg
    26221 accagttttc cacgtcgttg aaaactacat ccttatcgcg acaaaagcga tcctcagcat
    26281 gccatttggt ctcggtggtt tcttgattgg tggggttcac caattgatcg tcgtgtcagg
    26341 tgttcaccat atcttcaact tgcttgaagt tcaattgctt gctgctgacc atgctaaccc
    26401 attcaacgcg attatcacag ctgctatgac agcgcaaggt gctgcgactg ttgcggttgg
    26461 tattaaaacg aaaaatccaa aactaaaaac acttgctttc ccagctgctc tttctgcctt
    26521 cctcggtatt acagagcctg ctatcttcgg ggtgaatttg cgcttccgta aaccattctt
    26581 cctttcattg attgctggtg caatcggtgg tggattggct tctatccttg gacttgctgg
    26641 taatggtagt ggtatcacca tcatccctgg tacaatgctt tatgttggta acggacaact
    26701 tgcccaatac cttcttatgg tagctgtatc atttgcactt ggtttcgctc ttacttacat
    26761 gtttggttac gaggatgaaa aagaagttgc tactgaagta gagacagaac gtttggttca
    26821 agaagaaaca actggtaaca ttccagcagc tcttcaaaat gaaacacttg taactcctat
    26881 cgttggtgac gttgtagctc ttgctgatgt caatgaccca gtcttctcaa gtggagctat
    26941 gggacaaggt atcgctgtga aaccaagcca aggtgtggtt tatgcaccag ctgatgctga
    27001 agtttcaatc gcctttgcaa caggtcacgc ctttggtttg aaaacaacta acggtgctga
    27061 agtcttgatc cacgttggta tcgacactgt aacaatgaac ggtgaaggtt tcgaacaaaa
    27121 agttgcccaa ggtgacaagg tgaaagcagg cgatgttctt ggaacatttg actcaaacaa
    27181 aatcgctgca gctggtcttg atgatacaac aatgattatc gttacaaata cagctgacta
    27241 cgcttcagta gctccagtcg caacaggttc agttgcgaag ggggatgctg tgatcgaagt
    27301 gaaaatctaa tattcttcga aaatcaaatt caaaccacgt cagcttcnnn nnnnnnnnnn
    27361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    27421 nnnnnnnnnn nnnnnnnnnn nnnnnnngct tcctagtttg ctctttgatt ttcattgagt
    27481 acaatattcc ctctctaatg tgaaaacgaa caaatgacat gtttgttcgt ttttgcttga
    27541 atggtaagat ttacagagga aaatctaaaa aatagagaaa tttagatttt cgaaatatgc
    27601 tataataaag aaaataaaaa caagaggttt atcatgacaa aattatatgg aagcttggaa
    27661 gcgggcggta caaagtttgt ctgtgctgtc ggtgatgaaa attttaacgt tgtagaaaag
    27721 acacaatttc caacaacaac tccaatcgaa acaatcgata aaaccattga gttcttctca
    27781 aaattcgata accttgctgg tcttgcagtt ggttcatttg gtccgattga tattgataaa
    27841 aactcaaaaa cttatggctt tatcacaacg actccaaaac caaactgggc aaatgtggac
    27901 ttgcttggtg cccttcgtcg tgccctcaac gtgccaatgt acttcactac agacgtaaac
    27961 agctctgctt atggtgaagt ggttgcccgt aataatgctg gtgctcgtat cgaaaacttg
    28021 gtttactaca caatcggtac aggtatcggt gcaggtgtca tccaacgtgg tgagtttatc
    28081 ggcggtgccg gtcaccctga aatgggtcat tactatgtgg ctagacaccc aatggatatt
    28141 gaaaaagagt ttaagggtgt ttgtcctttc cataagggat gtctagaagg ctatgcagct
    28201 ggtccaagtt tggaagctcg tacaggtgtt cgtggggaaa atattgaact caacaaccct
    28261 gtttgggatg ttcaagccta ctatatcgct caagctgcgg ttaatgctac agtgactttc
    28321 cgtccagacg tgattgtctt tggtggaggg gttatggctc aacaacacat gctggaccgt
    28381 gtccgtgaga aatttacatc tcttctcaat ggttacctac cagtaccaga tgtacgtgac
    28441 tatatcgtga ctccagcagt cgcaggaaat ggttctgcta ctcttgggaa ctttgttctt
    28501 gcaaaagaag tttcaaaata aaacacaaaa tccgcttggg aaaccaaacg gatttttaca
    28561 tatcaaagca tttgccagaa aaagtcaata atataggtca gaccgtaggt atataccacg
    28621 agggtaaagg gcttggtcag aatgatgatg gtcatatagc gcttgaaact catcttggtc
    28681 agggcagcca gcatacagag aaagtcagct ggactaatgg gccaaatcat cataaagata
    28741 aagaaacggt caaaacgatt gcccttatcc agccaaccga tgtacttgtc gtaggtacgc
    28801 ttgctgacga cagactggac aaaggcagcc ccatagaggc gcacgagata aaagataatg
    28861 gcacagccaa tcacgattcc gatatagttg tagatagtac cgatgatgtg accgtagata
    28921 aagaccccag cgacggaggt caaggcccca ggaatgatag ggacgaccgt ttgtaaaatc
    28981 tgtaaaaaga taaagagagg tggcccccag atacctgcct gctggataaa ggcagagagg
    29041 gtttccttag actgtaaaac cccagcctga taagcccaaa tacagaaaat caaactccca
    29101 accccaccga taatcgatga gatgttgata acttgctgta aaaggggaga aacagctttc
    29161 atttgtttat cctgtgacat gtaaactcct catagatagt atagttctac tataccataa
    29221 tttacggttt taaactatct gagtgtctag aggtagaata attatggtaa aatggaaata
    29281 atcaaatgct aaattagatt gaggaagaat catgttggga ttaaagttta atgggacttg
    29341 gcgcaactac caaaaacagg tcttggacaa cttccaagaa taccaagcag atgggcatgt
    29401 tcacttggtg gcagcaccag gttcagggaa aacaactata gggattgagt tgattgcccg
    29461 ctttgataaa cctgctctcg ttttggtgcc gacggtcacc atccgagaac aatgggtaga
    29521 aaggattcgc caggcctttt tagaggatga ggaccaagtc acaagtctcg tgtctcaaaa
    29581 tctcaaggac atgaagcaaa tcaccatcgc cacctaccaa gtttttcaca gcgctatgca
    29641 acaggtacaa tctcaagaag ataatgggga ggttgaggac tttataggct ttgacctgct
    29701 tgacagactc aaggaaaggg gtgtagaaac cctctgtctg gacgaatgcc atcacttgag
    29761 aaacgaatgg tggaaaagtc tagaagactt ccgtaaaaac taccagcaac tgcaagtcat
    29821 ctctctcact gcgacaccgc cttatgacag tgaaccagaa ctctgggatc gttatctcca
    29881 gatgtgtggt gagattgacc aagaaatcac agtgccagaa ctggttaagg aagacactct
    29941 ttgccctcat caggactttg tctatatctg ttttccgacc aaggaagagg acaagcgctt
    30001 ggaagagttt gaagacacca agtggcagta tgtcagccaa ctagtcgttg atcctgactt
    30061 tcaagagttg attcggagtt ccaaggttct caaagggaaa atttctgcag atattcttct
    30121 tgaagatccc aagtatctct cagcgctcct catttatcta caagctcaaa aacaggaaat
    30181 tcccacgcat ctacaagatt tactaggagc tgaaggattg cctgccctca attattattg
    30241 gctagaaatt ctcttgcaag gccttctcta tcagactcct gactggtatg aggatcagca
    30301 ggagacaaag aaaaagatag aagcagaact gaaatcaaga gggttgattg aaaaacgtca
    30361 ggttttcttg gtcaaatcca aggccaatga ccaaatcctc aaccaatctc taggaaaact
    30421 ggctgggatt gcatctatat ttgaaactga gtatgatagt ctaggaaagg acttgagaca
    30481 gttagtcttg gcggactata tccgtaagga ttttgccagc tatctgggag atgaccaagc
    30541 accaatcacg caattaggtg tcctccctta ctttgaaact attcgcagaa gtgcacaaaa
    30601 gcaaggcttg tctgtcccga tagcagtcct ttctggtagt gtcgtgatca taccggctag
    30661 tgtcaaggct gaacttcaag cactcattcc aaacactagc ttaagcttct ctgccattgg
    30721 aaaactcgat caagatgttt atctccaggt aggctttcca tccagcttta aggggatggt
    30781 cgcagcagtg accgaactct tccaacgtgg ttctatccag gtcttggtcg gaaccaagtc
    30841 tcttttggga gaaggatggg atgcgccttg cgtcaactct ctcatcctcg gaagttttgt
    30901 cggaagcttt atgctcagca atcaaatgag gggccgtgcc atccgtatct ggccaggaca
    30961 tccagataag accagcaaca tctggcacct agtagccatc aaaccttaca aaaatccagc
    31021 cttttctaag gaggatcaag aagaactaga cctcaatcct tatcaggacc tccaaaccct
    31081 tgcccgtcgt atggaccatt tccttggctt gtcctataag gaagatacca ttgaaacagg
    31141 tttggaccgc ttaaactttc ctgagttccc atttaagaaa aagaaactcg aagactataa
    31201 cgagaagatc atggaactat ccaaggaccg tgcctcccta cgtaaaaaat ggcaggaatc
    31261 tctcattgtt gctgacaaga ttgagattgt caatgaagtg gcgacagaca gcaaacgaat
    31321 ccctctgctt gctctagcgg atgctgaaaa gtggcttcgc tacgctctga tggtatttgc
    31381 cattagtctc ctagcttatg tcgttcgact aaccttcttt gccttgccat ggttgacagc
    31441 tctttgtgtc ctcttcctag ctatcacagc ctttcgctat tacagctaca agagtcctta
    31501 taaacgcttg cgccagatcg gtgaagctat tcgcaaagtc atggtgactg ccgggcattt
    31561 atctgatgac cagtcgcgcg tgcaggtcga ggaggacaag gaaagcttta acgtattttc
    31621 ctatctaaaa ggtggcagca tgcgagacaa ggagctcttc tctcagacct tgggtgaatt
    31681 ctttgctccc gtggacaatc aacgctacct cttagtagtt aaaaaagcac cagcaggtca
    31741 gtccaagtat tttgtggttc ctagcctctt tgaaaaacgc aaggaagatg cccagctctt
    31801 cctagatgcc gtcgcacctc agataggtga ttaccagcta gtctacaccc gcaacgaagt
    31861 agggagaaaa atcctgctag aagctcgact caaatctcta gccaacaaaa atgaccgcat
    31921 cattactaag aaaaaggtca aaagtgcgtt gaagtaggga gggggaagaa gttattttca
    31981 cttggaatat gatataataa tagcaaaaat gttgtccctg aaggaaaaat atagatgcag
    32041 ctaaaaccag aactggagat agaaaaacag ctgatcaacc aactggtgac tggggaaagt
    32101 caatggactt acagagatga acttaaaaca gaagagcaat tatgagaaag cttctttgaa
    32161 aagctagctc agaacaatgt ggctctattg gcaaatcatc accttccaaa agcctctagc
    32221 ctttaaagaa gcagtcgata atgccctcaa gctctattca aatggtggag aaaacgaggt
    32281 cctagcccct agctgggaag aggaaaagag gaacttttta cggagttgca gtgatttcca
    32341 aaatctcatc accgatgatc cggaggaagg actccaaatc gagcagattt ctacacctga
    32401 gttgagaaag ctcgccaagg cctatcaggt ctttgataaa tacctagctt ctatccgagt
    32461 ttataaagag tatgatgaag aagaaatcta cgcccagaca ggactaagcg cagaagaatt
    32521 ggaaacctat cttggcttct atcaaaacat cctagctgaa ttaaaaagcc gaagagatga
    32581 tggtggtgaa gatggggagc cccttgatat tcactatgaa ctagagtcta tccaagtgga
    32641 tgagattaac tatgcctata tcctaacctt aatccaaagc ctgatcgagc aaggtcagag
    32701 tcaagaaaag aacctaagcg ctcaagatag agaagcagtg gatagctata ttcagagcct
    32761 tgagaagatc aatccaaatc ttgcccatat catcactgaa ctatggaagg aagtacagga
    32821 taagtcagaa agctatcgcg gtcagtctat cgcaaatatc ctggatcaga tgatcgaggc
    32881 ggttatccag caacatatcc aagtctttag caaacgttgg tatgtcggag aggatgagct
    32941 ccgttactat gtcgagcact accgcaaggg agctaaaaaa caactaggag agagccagct
    33001 gaccaagagc cagcgctatc aggactataa gatagaagtg gcagatgccc tcaatcccct
    33061 cctctataaa aagcaaatca aggaagcctg taagcaactt gtcgaagaag tcattgagcc
    33121 actcagagtt gggagatagt ccttcgaagt tacgaagaca tagacttcct aaagtttaca
    33181 tgcattctaa acttagaatg ataaggaata cataaattta tgggtatcct aagcttcgaa
    33241 tagtctatct gagaaagttt tggggtcttc gagctttcga atagtcatct ttcctaaagt
    33301 ttagatgtat tctaaggcta gaaaagttaa aatctgaaaa tagtaagagt ctctatctga
    33361 cagacggagt gtatttccag tcagataggg attttctatt tctgaaatga cggatttatt
    33421 ctataaaagt aaaaaatagc caaaaaaagt gctgttggga tgataaagta gacagttgag
    33481 cggatgagtg tcataagttc tttgctattt gttagaattg tcttatcaac ttaaaggaga
    33541 aaatctgatg aagagagata aagaaaatga ggagagtatc ctatcggacc ttcctctgtg
    33601 gggactccta tttttggtct gtgtattgct tcaagtctat gtaggaaagg atagaccttt
    33661 gattcaacct gatagacaag gaagcattgt aaaaacaaat caaaaacagg tctatcttcc
    33721 agaactaatc cagtctttat ttgataaaga aaaaactaaa tgattcgtta aatagaaagg
    33781 ttatcatcat gacaaaaaca tttaccatcc gtccgctaag ctataccaac tttaccaacc
    33841 gtgagtttga gagtctcatg gtagacacgg gtcaactact agaagttttt gctaaggcac
    33901 ataaggacga gtctatgtat agcaagcatc tcgattcctt caagagcaag ttagcagact
    33961 tccaagctca actagctatc gtagaaaaga aagaggcgac gaacctgacc gaagtcgatc
    34021 gcaatcgtga cagtgcccta gtcggtctct ttactcttca tcgaggattt gctaagatca
    34081 aggagaccaa actcaaagaa gcccatgaga ctttgaaacc agtctttgcc aagtacaagg
    34141 atatcaccaa gcatagcaat gatgtggaaa cggcagaaat caagagtctg ctcaaaacgc
    34201 tcagcgaaga accctaccag acggcagtta ctagcctagg actaacccct atgcttacgg
    34261 cggtaatcag tgcgcaagag gaatatgata aggtggaaag tcaggcgcgt gctcataagt
    34321 ctgccaagga agtcggcaag accagacaag tccgtaccga actaaccagc atctacgtcc
    34381 tctttatgcg ctataccgca gccagtgcag aagcctaccc agaaaaagag cacctaacca
    34441 aactccttaa agacctcaat acaatccgag acagtaaacg acgattgact ggttcaagta
    34501 agaaggataa gaaagtgaaa accgaagaaa ctacacaagt agctggataa aaaataaacg
    34561 tctttagata tattattatc taaaggcgtt ttttggtgaa ttcgtggtat aattttaggg
    34621 aaagtttaag gttataaaat atttttttta gaaagagata ctatggatga tagattcatt
    34681 acattaaagc acattgatac ctccgtagca gctaaaaatg tcgctaaatt acttgaagaa
    34741 aataaaactt atttcttaaa tgggaactgg ggttctggaa aaacagaatt tctagttgaa
    34801 gttggtaaga atactaataa aaaattagtt acgatagact tttggagatt aagcgatagc
    34861 cgctcaacaa ttgaaattat tttttcaaaa ttacatccgt ggaaatacag gtttttaagg
    34921 tttttcatag ttttatgtgt tgcattatca atcctaatga caaatgtagt tgatttgggt
    34981 ttaagttctt tttttgaatc tttttgtgtt aaattaattg ttgggagtat tgttttatta
    35041 gtagcaatct accaattttt caaagtcaaa tctgatggtt tttacagtcg tttgctaaca
    35101 tttaagtatt tgtcattagc tcgaaaagtt ctagttattg atgattttga tcgaatgtct
    35161 aacaaacaac aagaagagag ttataaaatt tttagtttac tcagtggtaa gcttccgatt
    35221 gtctttgtgg gagacattga gaaagtacat cttaaagaca ataattttct ttctaaaata
    35281 attgatagaa ggatagagct accatttgtt cttcatccat caaatatttg gcaagattat
    35341 tttgacttgc taggaaagaa atttagtacg agattgtcag atgatttttg gagaaggttc
    35401 aggtttgaaa atagaaactt gcgagataga aatcatttta atgactatgt caatcaagaa
    35461 ttcttttcaa gggggaaact aggacatgtt caggaggaac agcaactttg gattatctat
    35521 acctaccttt tttatcctga attatataaa caattattaa aggctgaaga aataaaagtc
    35581 aaggatgatg aaaaaattag ttttacatgg ctgttcaagt ttggacgaag catagaagaa
    35641 atactgtccg acattcaaca atcagatctt acccaatatc caccaagcta taaaatgaat
    35701 agctcggcct attttcttta tgaagaatct ctaaatcgta caaaagaaga attggattca
    35761 ttacttgaga cagatagtga ggaattatca agagaactaa gagaggggaa tcataagact
    35821 gatttttatc aatatctttc aagtgaatat aaatcatttt ctgaaaatca gaaagctaaa
    35881 ctactacgta ttaccataca agaatctctg aaatcttata atagccctgc aatggactat
    35941 attgttgcag aaaagttaaa tgaagaaatt ccccgatatg agaggaatag tcctttaagt
    36001 gaagaaataa taggtagaat tgtgaatttc tgggaaacta ttctgagaaa agaaggtttg
    36061 gatccgtctg agatacttta ttttatggaa aaacatagag tgctgacctt ctatgatttg
    36121 ggacgtcact attcaaactt agaaattaat aataaaaatt tcgctaagct aagacgaaaa
    36181 gatttcttcc tcttgaccta tcttagttca attgaaaaat ttaatgaatt tgaaagttgg
    36241 gatagaagta tctgggatgc catggagcag tttggaggca gagagttctt agtcttttgg
    36301 gaatttcaag gaattctttc aaatggattg ggttattact gttttgatgt tgttcctaga
    36361 aacaaaaaat attttcttat gatggatgaa aatcaagata aaatgaaaaa taataagtct
    36421 gtcattgaaa agattcagcc acaacttgag caattggaag ctaaaggatt tacattcgag
    36481 gagaaaatag atagggaata ctggtaggta atctatgagt tttaaaggat aattgattag
    36541 tatgttctcc ttttagtaat atccttcatg tttgtaccct tttttgtgtt aaatttcgct
    36601 cccactcgtt ctccctaggt cgagtggttt ttcttgaaat atgataaaat agaaaagata
    36661 atacattaat taaggaaagt aaaaatggca agtaaagaaa atgcagaacg caaggtgctg
    36721 catcgtaaaa tttgggcgat tgctgatgat gtgcgtggag ctgtagatgg ttgggatttt
    36781 aagcaatata tcctaggtat ccttttctat cgttttattt cagagcatat ggctgactat
    36841 tttgaccgtg ctgagcatga ggctggcgat ttagaattcc gttatgctga attgagtgac
    36901 caagaggctg agcaagattt taaaccaggg acagttgagg ataagggatt ctttatcctt
    36961 ccgagtcaac tatttgaaaa tgtagtcgag aatgcctcgc aaaatgaaaa tttaaacgaa
    37021 gacttggcca atattttcca agctattgag aagtcagcga ttggcttcaa atcagaagat
    37081 gatatcaaag gtttgtttga taacttagat acacgaagta acatccttgg aggaagtgtt
    37141 ccagaaaaaa ataagcgcct atctgatatc ctcaatggta tcaatagcat taactttggt
    37201 aattttgagg aaaatgatat tgatgccttt ggggatgcct atgagttctt gatttcaaac
    37261 tatgcgagta atgctggtaa aagtggtggg gaatttttca ctcctcagac agtttctaaa
    37321 ttactagctc gtttggtaat ggttggtaag gacaagatta acaaagtcta tgacccaaca
    37381 tgtggttcag gctctctcct tcttcaaatg aaaaaacaat acgaagacca tatcttggag
    37441 gatggtttct ttggtcaaga aatcaatatg accaactata acttggctcg tatgaatatg
    37501 ttcctacaca atatcaacta taataacttt gatattaagc gaggagatac ccttttaaat
    37561 cctcagcatc tggaagaaaa gccttttgat gctatcgttt ctaaccctcc gtattctgtc
    37621 aaatgggtgg gagatggaga tccaactctg ataaacgatg accgttttgc gccagcaggg
    37681 aaactagctc ctaagtcaaa agctgacttt gcctttatca tgcatagtct caatcatctg
    37741 tctaataaag gtcgagcagc tattgtttgt ttcccaggca ttttctatcg tggaggtgct
    37801 gaaaagacca ttcgtcagta tctggtagat aacaactttg ttgaagcagt cattgccctt
    37861 ccagacaatc tcttctttgg aacttctatc gcaactacaa ttttagttct ggcgaagaat
    37921 aaattagaaa ataaaactct ctttatcgat gcgagtaaag aattcaaaaa agagaccaat
    37981 aacaacgtct tgacggatag caatatcgag tatattgttg aattattctc taattatcaa
    38041 aatgtagact ataaagcaac tcttgttgat aatgaggtga ttggctcaga gcaagattac
    38101 aacctatctg tctcaaccta tgttgaacaa gaagatacac gtgagaagat tgatattgat
    38161 atgcttaata aagaaatcgc tgagactgtg acaaagattg accacttgcg tgcagagata
    38221 gacaagattg tagaggaatt gagccatggc aaatgatgtg attctctata gaacagatga
    38281 cggcaagtct gcaattgaac tccacttgga taatggaacg gtctggctga cccaacaaga
    38341 actagctgag ctctttcaaa cctccaagca aaacattagt aaacacatca aggcgatatt
    38401 tgaagatggt gaattggatg aaacagtggt tgtcaactat cagttgacaa ccactcgtca
    38461 cggtgcaatg gctggtaaaa ctcagtcaaa aaaagttgct tactataatt tggatatgat
    38521 tttggcgatt ggctaccgtg tgcgctcccc tcgtggggtc cagtttagac actatgcttc
    38581 gacagtcttg aaagagtatc tgatcaaggg attcgctatg gatgatgagc gcttgaaaaa
    38641 cttgggtgga ggctcttact ttaaagaact cctggaaaga atccgagaca ttcgctcgag
    38701 tgaaaaagtc ttttaccgtc aagtcttgga tctttttgcg acatcaagtg actacaatgc
    38761 aaactcacca gaggcaaaga aattttttgc gacggttcaa aacaagatgc attatgctat
    38821 tcaccacaat actgccagtg aactcatcta caatcgtgtc gatagcgaaa aggagtttat
    38881 gggcttgacc acttttaagg gagaccttcc cactctatct gaagcaaaag ttgctaagaa
    38941 ctatctgaca gaaaaggaac tccgtgggct taatcagctt gtatcaggat atctagactt
    39001 tgctgaaaga caggcggagc gagaagaagt catgactatg gcggactggg tgacacatgt
    39061 agaccgtatc cttcaggcta ctggagaaga cttacttgat aatagtggtt ctatttctcg
    39121 tgaacagatg aagcagaagg tagataagga gtataagagc taccaagcca agacccttag
    39181 tcaagttgaa aaagattacc tcaaggaaat taaaagtatt gaaaatctag ccaaggaagg
    39241 aggtaactaa tgaacatcct agaagaaatc caaaactgtc ctgttgaatg gaaagagttg
    39301 ggggaagttt gttctgttaa gaaaggtaag caactaaata aaaatttatt gacagaagat
    39361 ggattatatc ctgcgtataa tggtggacaa acttattcag gaagaactaa tgattacaac
    39421 gtggaagcta atacaatcat tgtaagtcaa ggtggagctt ctgcgggttt tgttaatttt
    39481 gtcgatacca aattttgggc taatgcacat tgttattata tacttcctga tgagactcga
    39541 gtgaataata gatttgtata tcattttgta aaaatgaatc agaaatatct tatggatttt
    39601 caacatggag cggggatacc cgcgttaaaa gctgacaaat tgtccaaact attactcccc
    39661 atccctcccc tagaaattca agaaaaaatc gtgcaaatac ttgacaaatt caccgattat
    39721 gttacagaat tgacctcaga attgacctca gaattgacct cacgtaaaaa gcaatattct
    39781 tattatcgag ataaactttt atcatttgag gatgaagttt atcaggttga gtggaaaaca
    39841 ctgggggaag tcgctaaatt taattatggt tatactgata aagcgaaaga tattggagat
    39901 gttagattca ttcgaatcac tgatattgat gaaaatggtt atcttaagcc gtatgataaa
    39961 aaatatattg ccttaacgga agcatcaaga agctatttag taaaatatgg tgacttattg
    40021 atggctagaa cgggtgctac ttttggaaaa acgctattta ttgatacaga tgaaactagc
    40081 gcgtatgcct ctttcttaat caagattact ccctcagaga agttgaattc aagatactat
    40141 tggcattttt caaagagtga attgtattgg aaacaggcta ataatttagt ttcaaaggct
    40201 ggccagcctc agtttaatgc aaatagtctg aagaatgtaa aaatcccagt cccttccctc
    40261 gaaatccaat ctcgaattgt tcaagttcta gacaactttg acacggtttg taatgaccta
    40321 aacatcggac tacctaagga gattgaactt cgtcaaaaac agtatgaata ttttagagaa
    40381 aaactcttga cattcgtcgc cgaaggcgag tacactgaga gtagagtaga gtagagtaga
    40441 gtagaggagt gggacaactc cgctattatc aaacttttac agtgggtatt tggcccgatt
    40501 cgagtagagt tgggagcagt tgcagaatat agtcaaaaga ggattagtgt gacagattta
    40561 actcctgaaa cttatgttgg agttgataat ttgttgcaag atagaaaagg gaaagcagtt
    40621 gctacatttt tacctgatca aggaagtgtt acaacctata atcagggtga tatattgatt
    40681 ggtaatatca gaccttatct caaaaaaatt tggttttcta atcaagttgg tgggacaagt
    40741 ggagatgtct tgacaattca aaattctatt actccttgta tggaaaataa atatttatat
    40801 tatattttgt cagatgatcg attcttttat tataatgtgc aatattcaaa aggttctaag
    40861 atgccccgag gagataagaa agctattatg caatataagt ttatattgcc atccattaca
    40921 gaacaaaaaa gaatcgtctc tacccttgac aatttcaata ctttaaccaa ctctctttct
    40981 gaaggtcttc caaaagaaat cgaactaaga cagaaacagt atgaatactg gagagaacaa
    41041 ttattaaact ttactagata aattcttgaa gcattttgag atagaatctc aattaaaata
    41101 aaaaaaggaa gcatactatg gttgattatt caaaagtaca tgaagtaatt gcggaaacaa
    41161 atgaagggat tct
//
