LOCUS       NZ_KV802690            20876 bp    DNA     linear   CON 08-NOV-2024
DEFINITION  Streptococcus sp. HMSC073F11 Scaffold211, whole genome shotgun
            sequence.
ACCESSION   NZ_KV802690
VERSION     NZ_KV802690.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptococcus sp. HMSC073F11
  ORGANISM  Streptococcus sp. HMSC073F11
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 833953)
  AUTHORS   Mitreva,M., Pepin,K.H., Mihindukulasuriya,K.A., Fulton,R.,
            Fronick,C., O'Laughlin,M., Miner,T., Herter,B., Rosa,B.A.,
            Cordes,M., Tomlinson,C., Wollam,A., Palsikar,V.B., Mardis,E.R. and
            Wilson,R.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2016) McDonnell Genome Institute, Washington
            University School of Medicine, 4444 Forest Park, St. Louis, MO
            63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Velvet v. 1.1.06
            Genome Coverage                   :: 213x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001810785.1-RS_2024_11_05
            Annotation Date                   :: 11/05/2024 23:57:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,892
            CDSs (total)                      :: 1,845
            Genes (coding)                    :: 1,788
            CDSs (with protein)               :: 1,788
            Genes (RNA)                       :: 47
            rRNAs                             :: 1, 2, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 2, 3 (16S, 23S)
            tRNAs                             :: 38
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 16 of 57
            Pseudo Genes (incomplete)         :: 34 of 57
            Pseudo Genes (internal stop)      :: 10 of 57
            Pseudo Genes (multiple problems)  :: 3 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:06:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 537871
            Orig. end                         :: 558747
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KV802690.1.
            The WUSC is a large strain collection isolated from clinical
            samples. Each sample is associated with metadata, including source,
            isolation site, 16s rRNA, metabolic, and other phenotypic
            information. The goal is to sample an adequate number of important,
            yet minor species, further adding to the catelogue of sequenced
            bacterial genomes and improving the diversity of the genomes
            available to the public. WGS will be preformed on approximely 550
            isolates. Samples were selected based on RDP analysis at the genus
            level. This is a reference genomes for the Human Microbiome Project
            and the work was funded by the National Institutes of Health (NIH)
            grant U54 HG004968.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20876
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20876
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20876
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10876](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10876
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    218..233
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     gene            469..1749
                     /locus_tag="HMPREF2764_RS04240"
                     /old_locus_tag="HMPREF2764_04250"
     CDS             469..1749
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (58-224). E-value:
                     4.5e-12. Score: 37.7. Matches aSDomain:
                     nrpspksdomains_HMPREF2764_RS04240_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604466.1"
                     /locus_tag="HMPREF2764_RS04240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04250"
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase family
                     protein"
                     /protein_id="WP_070527418.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6.3e-11, bitscore:
                     37.6, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.1e-16,
                     bitscore: 54.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 2.5e-09, bitscore:
                     32.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRDFQFETLQLHAGQVVDPATKSRAVPIYQTTSFVFDDTQEGAD
                     LFALRKPGNIYTRITNPTTAAFEERIAALEGGVGALATASGMAAVTYTILALAHAGDHV
                     VAASTIYGGTFNLLKETLPRYGITTTFVDVDNLEEVEAAIGDNTKLVLIETLGNPLINI
                     PDLEKLAEIAHKHQIPLVSDNTFATPYLINVFSHGVDIAIHSATKFIGGHGTTIGGVIV
                     DSGRFDWAASGKFPQFVEEDPSYHNLSYTRDVGAAAFIIAVRVQLLRDTGAALSPFNAF
                     LLLQGLETLSLRVERHVQNAEKIVDFLVNHPKVEKVNYPKLADSPYHALAEKYLPKGVG
                     SIFTFHVKGGEAEARKVIDHLEIFSDLANVADAKSLVVHPATTTHGQLSEKDLEAAGIT
                     PNQIRLSIGLENVDDLIEDLRLALEKI"
     misc_feature    480..494
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.38"
                     /tool="antismash"
     aSDomain        643..1140
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HMPREF2764_RS04240_Aminotran_1_2
                     .1"
                     /evalue="4.50E-12"
                     /label="HMPREF2764_RS04240_Aminotran_1_2.1"
                     /locus_tag="HMPREF2764_RS04240"
                     /protein_end="224"
                     /protein_start="58"
                     /score="37.7"
                     /tool="antismash"
                     /translation="ITNPTTAAFEERIAALEGGVGALATASGMAAVTYTILALAHAGDH
                     VVAASTIYGGTFNLLKETLPRYGITTTFVDVDNLEEVEAAIGDNTKLVLIETLGNPLIN
                     IPDLEKLAEIAHKHQIPLVSDNTFATPYLINVFSHGVDIAIHSATKFIGGHGTTIGGVI
                     VDS"
     gene            1845..3119
                     /locus_tag="HMPREF2764_RS04245"
                     /old_locus_tag="HMPREF2764_04255"
     CDS             1845..3119
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /locus_tag="HMPREF2764_RS04245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04255"
                     /product="DUF2130 domain-containing protein"
                     /protein_id="WP_070527421.1"
                     /transl_table=11
                     /translation="MNEIKCPNCGEVFTVNESQYAKLLSQVRTAEFDKELHDRMKQELA
                     LAEQKAMNEQQSKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSNQALLAKDKEVQA
                     LENQLATLRLEHENQLQKTLSDLEKERDQVKNQLLLQEKENELSLASIKQNYEAQLKAA
                     SEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSARGSKGDF
                     IFRECDESGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLVTMLEA
                     DNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVREQNIDIT
                     HFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQLRLANNKL
                     EDVSVKKLTRKNPTMKAKFEALKGE"
     gene            3127..4797
                     /locus_tag="HMPREF2764_RS04250"
                     /old_locus_tag="HMPREF2764_04260"
     CDS             3127..4797
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000426759.1"
                     /locus_tag="HMPREF2764_RS04250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04260"
                     /product="hypothetical protein"
                     /protein_id="WP_044020625.1"
                     /transl_table=11
                     /translation="MENELLVLNTEEVNESENLNYDELEELLEQQFTMEFSNLEKLEVD
                     CKEISSPDKLGDVILDEIWNQFGNQIGLDMTSDTLLKQYNEKNPNGYTKEIADQIVKDK
                     RYTDANKAMKHKQKLGNLKDEYTGKKLKINEKANLDHIVPRKQIFENPWRKIADIDPSD
                     LANKSENLSATNESLNKSKGAKSNSDYIKNKELRERNLREQVKKANEKIDKMNISDAEK
                     RNLKAENNKRLNDKLAADSKKMLKAEKTAKKAINKDIAKKASVRMANKAGKDAIKAMFV
                     AALFGMLKEIMNALVRYFKAKKQSFDTFMEEMKKALHSFFGKIKDFIKVGVDSFVGSIV
                     GEIIGAFNQKLQKLPNLIKQLFGSIRESISYLSNPENQTHSTAIKIAHISKIITSGLVA
                     VGAMFLGEYFEQFLNKVPGMTFEIKLLGTIANILGMFFASLLTGILGAIIINGLDQFIS
                     KKLIEENQKKQANKKNELLRIQDVQIFVAEQNVAVKRNDIFIKMAKNHQKLRELLGNVQ
                     EEFSNSKIDFKQRLLANEIYFDEKQSELEEMQSALNDLL"
     gene            4807..5607
                     /locus_tag="HMPREF2764_RS04255"
                     /old_locus_tag="HMPREF2764_04265"
     CDS             4807..5607
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288177.1"
                     /locus_tag="HMPREF2764_RS04255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04265"
                     /product="hypothetical protein"
                     /protein_id="WP_001288177.1"
                     /transl_table=11
                     /translation="MSEELEIQVLAKSERFNEKKEALKAFSEEIPEQSDLPTVPQDDPM
                     LGFIGMEYDVKGKDLNALTDAVQNRMIEQNKHIKKIIQEFNTIYETFQILDDEYIQSIS
                     KSLIAAKEANDKAMQGLHEIEEYQTGNKKLLDDVFNQNKDLIDILKKHHKKLEELEQLE
                     EKQSEIQIEIDTLKANLKTLVKIENSFNDLHLQVEEKQNNFKNFLDEINNKSITERDNL
                     KLIVESLETKLEEKQKEIVFLRKGFYTLVVAVVLIVLFLLFKGM"
     gene            5608..6693
                     /locus_tag="HMPREF2764_RS04260"
                     /old_locus_tag="HMPREF2764_04270"
     CDS             5608..6693
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000622664.1"
                     /locus_tag="HMPREF2764_RS04260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04270"
                     /product="AAA family ATPase"
                     /protein_id="WP_000622662.1"
                     /transl_table=11
                     /translation="MISETYLKLLKSEVKKIDDLTNSTYELEVILQDIVDNVKNADLEF
                     IKRLGNLTTKETFSTIKDKQTSILELLYKYLGSRVIDTNYLILKETNNKSFEALANDLK
                     SLIGLENVKKEIEDLVAFNKVQQSREKIGLKKTNRTMHMAFLGNPGTGKTTVARIVGNM
                     YRSLGILSKGHFIEASRTDLIAEYQGQTASKVKRLIQKAKGGVLFIDEAYSITENDKSD
                     SYGRECLTELTKALEDYRDDLVVIVAGYDELMKKFFESNPGLKSRFNYFITFEDYTVDQ
                     MFDIFLSHCKNEEYILHDSAKETLKKYLELHSNNPENKNANGRFVRNVFDRIVMNQARR
                     LATLSFVTKDNYITILEEDIS"
     gene            6714..7592
                     /gene="truB"
                     /locus_tag="HMPREF2764_RS04265"
                     /old_locus_tag="HMPREF2764_04275"
     CDS             6714..7592
                     /EC_number="5.4.99.25"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="truB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145474.1"
                     /locus_tag="HMPREF2764_RS04265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04275"
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="WP_070527879.1"
                     /transl_table=11
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVLGVL
                     PIAVGKATRMVEFMQDEGKVYEGEITLGYSTTTEDASGEVVAETPVLSPLDETTVDEAI
                     ASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYESELA
                     RFTFRVKCSKGTYIRTLSVDLGKKLGYAAHMSHLTRTSAAGLQLEDALTLDEIAEKVDV
                     GQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDQELAAFEGDTLLAILEKR
                     GNFYKPRKVFS"
     misc_feature    6724..6738
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 23.46"
                     /tool="antismash"
     gene            7707..8345
                     /gene="udk"
                     /locus_tag="HMPREF2764_RS04270"
                     /old_locus_tag="HMPREF2764_04280"
     CDS             7707..8345
                     /EC_number="2.7.1.48"
                     /GO_function="GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="udk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /locus_tag="HMPREF2764_RS04270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04280"
                     /product="uridine kinase"
                     /protein_id="WP_001181372.1"
                     /transl_table=11
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKD
                     QSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTAHTRSSKTYRQEP
                     QDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVIEQYLG
                     VVKPMYHQFIEPTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     gene            8474..9814
                     /gene="xseA"
                     /locus_tag="HMPREF2764_RS04275"
                     /old_locus_tag="HMPREF2764_04285"
     CDS             8474..9814
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417449.1"
                     /locus_tag="HMPREF2764_RS04275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04285"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_070527424.1"
                     /transl_table=11
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDGVG
                     ALAIQFEQLKKKLTEEGLFQERFKQPLPQFAKRIGVVTSRSGAVIRDIITTVSRRFPGV
                     GILLYPTKVQGDGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIF
                     ESRLPIISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDLLTHLQNQEKRMATA
                     VRNVLSKKQESLKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDSKHLVQA
                     RTHQLVQLSPVPKIQRYQDRLAQLDKLLRSQMALVYDAKVAEVKRLSEALLMLDTSRIV
                     ARGYAIVKKEESVVDSVEMLNKKDQVTLLMRDGQVELEVKDVKTKEI"
     misc_feature    complement(8514..8528)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.47"
                     /tool="antismash"
     gene            9792..10004
                     /locus_tag="HMPREF2764_RS04280"
                     /old_locus_tag="HMPREF2764_04290"
     CDS             9792..10004
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /locus_tag="HMPREF2764_RS04280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04290"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_000043226.1"
                     /transl_table=11
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAIAAFQKGMVLSKEL
                     QATLDKAEKTLVKVMQEDGTESDFE"
     gene            10001..10876
                     /locus_tag="HMPREF2764_RS04285"
                     /old_locus_tag="HMPREF2764_04295"
     CDS             10001..10876
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /locus_tag="HMPREF2764_RS04285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04295"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_070527427.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.9e-56, bitscore:
                     185.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPF
                     LLLEVLEALQVAIKPAHAQVAAALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEA
                     MAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLS
                     LEELQTIHANKTGKLLAYPFQAAAIIAELEPEMQAKLKTIGELIGLAFQVRDDVLDVTA
                     SFEEIGKTPQKDLQAEKSTYPALLGLEVAIAFCNQTLDQANAKLEEIAQQVPFEIESIV
                     KVVESLRING"
     gene            10869..11684
                     /locus_tag="HMPREF2764_RS04290"
                     /old_locus_tag="HMPREF2764_04300"
     CDS             10869..11684
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /locus_tag="HMPREF2764_RS04290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04300"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_070527430.1"
                     /transl_table=11
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPGE
                     KIPDETELKLKGEKLKYVSRGGLKLEKALQVFDLSVEGATTIDIGASTGGFTDVMLQNG
                     AELVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISLSLI
                     LPALHRVLAEQGQVVALVKPQFEAGREQIGKNGIIRDAKVHQTVLESVTAMAVEQGFSV
                     LGLDYSPIQGGHGNIEFLVYLKKEEGASNQVAPEIEKVVERAHREFKDE"
     gene            11677..12108
                     /locus_tag="HMPREF2764_RS04295"
                     /old_locus_tag="HMPREF2764_04305"
     CDS             11677..12108
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /locus_tag="HMPREF2764_RS04295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04305"
                     /product="arginine repressor"
                     /protein_id="WP_001034390.1"
                     /transl_table=11
                     /translation="MNKKERLEKIRRFVTDYQIGTQEEIVEHLKEAGISATQATVSRDI
                     KELGIVKIPLKNNTYIYELPKSIVKSLQLAEDNIVSSELMGNMINLAVIPGNTIFVKSQ
                     LVEAFSEQIFSCLADDDSILIVARTAEAAEEIVEQVKKW"
     gene            12115..13782
                     /gene="recN"
                     /locus_tag="HMPREF2764_RS04300"
                     /old_locus_tag="HMPREF2764_04310"
     CDS             12115..13782
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /locus_tag="HMPREF2764_RS04300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04310"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_070527434.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNLM
                     LGARATTDVIRHGAPKAEIEGLFSVENSRLLQELFEEQGLELGDEIIIRREILQNGRSV
                     SRVNGQMVNLSVLRAIGQHLVDIHGQHDQEELMRPQLHIQMLDEFGDATFLDLKETYQT
                     SFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLALNQEREKLLNH
                     KNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYYVLEDI
                     SKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEYNLLTGN
                     NLSSEDMEAELKKLEVILVDLAGQLASARHDLAQQLEAEIKQELQDLYMEKAQFQVRFS
                     KGKFSREGNEMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKEGKTSIVFD
                     EVDTGVSGRVAQAIAQKIHKIGQHGQVLAISHLPQVIAIADYQFFIEKISDEHSTVSTV
                     RLLTIEERVEEVAKMLAGENVTEAALTQARELLQTRMK"
     gene            13783..14511
                     /locus_tag="HMPREF2764_RS04305"
                     /old_locus_tag="HMPREF2764_04315"
     CDS             13783..14511
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /locus_tag="HMPREF2764_RS04305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04315"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_070527436.1"
                     /transl_table=11
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTKLLFLGDLIDRGEDSRR
                     VLEMVKDLVDNQGAICLSGNHEYMFLTWLDNPEESYDHYRRNGGDTTINSILGRPLDAP
                     VDGVEDAKRVATEEADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVWLR
                     KPFHEAENHTGKTIVFGHTPVYGLLKQERGTAELWTTEDGKIGMDGGAVYGGVLHGIVF
                     TDQGMTEHHFIENDGFVAED"
     gene            14590..16413
                     /gene="lepA"
                     /locus_tag="HMPREF2764_RS04310"
                     /old_locus_tag="HMPREF2764_04320"
     CDS             14590..16413
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="lepA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /locus_tag="HMPREF2764_RS04310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04320"
                     /product="translation elongation factor 4"
                     /protein_id="WP_070527439.1"
                     /transl_table=11
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREM
                     QAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAAC
                     EGAILVVDAAQGIEAQTLANVYLALDNDLEIMPVINKIDLPAADPERVRTEIEDVIGLD
                     ASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQVRVM
                     DGVVKPGDKIQLMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVQDTRVGD
                     TVTLATNPAAEPLYGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETS
                     QALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMDVSNPSEF
                     PDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLA
                     EIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFIVHKDFAYER
                     GKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGGDVSRKRKLLE
                     KQKAGKKRMKAIGSVEVPQEAFLSVLSMDEE"
     gene            16675..17151
                     /locus_tag="HMPREF2764_RS04315"
                     /old_locus_tag="HMPREF2764_04325"
     CDS             16675..17151
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /locus_tag="HMPREF2764_RS04315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04325"
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="WP_070527442.1"
                     /transl_table=11
                     /translation="MGLDHFFDKNLVFCLEADNQEHLFDQVATLLEEREIVTPTYREAL
                     ITREKSFPTGLDMEFLGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIVPDKEV
                     EVSLLFFIINNSSSSQTNILAQLMDFFTGNGHLEDLSKISEPEALYTYIAEAIA"
     gene            17190..17495
                     /locus_tag="HMPREF2764_RS04320"
                     /old_locus_tag="HMPREF2764_04330"
     CDS             17190..17495
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590575.1"
                     /locus_tag="HMPREF2764_RS04320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04330"
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="WP_000590547.1"
                     /transl_table=11
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGFDVHCDAVMVKDVNE
                     DLIKGYDIFTPIAATDLGFDPGIPVIEAGPILFRIPAMSAPVFDNIEAAIKEHGLS"
     misc_feature    complement(17506..17523)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.83"
                     /tool="antismash"
     gene            17543..19018
                     /locus_tag="HMPREF2764_RS04325"
                     /old_locus_tag="HMPREF2764_04335"
     CDS             17543..19018
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000382512.1"
                     /locus_tag="HMPREF2764_RS04325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04335"
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="WP_049486886.1"
                     /transl_table=11
                     /translation="MDVIINLANDIFKPILAMGGPIIMLIILTVLALLFGVKFSKALEG
                     GIKLAIALTGIGAIIGMLNGAFSASLAKFVENTGIQLNITDVGWAPLATITWGSAWTLY
                     FLLVMLIVNVVMLAMKKTDTLDVDIFDIWHLSITGLLIKWYADNNGVSQGVSLFIATAA
                     VVLVGILKIINSDLMKPTFDDLLNAPSSSPMTSTHMNYMMNPVIMVLDKIFDKVLPGLD
                     KYDFDAAKLNKKIGFWGSKFFIGFILGIVIGLMGTPHPVAGVEDASSWELVIKGWLSLG
                     LTAGVALELFSLIGSWFIAAVEPLSQGITNVATKRLEGRKFNIGLDWPFIAGRAEIWAC
                     ANVLAPIMLIEAVLLSNVGNGILPLAGIIAMGVTPALLVVTRGKLLRMIIFGTLLLPLF
                     LLSGTLIAPFATELAKGVGAFPEGVSQTQLITHSTLEGPIEKLLGWTIGNTTTGDIKAI
                     LGAVVFLVFYIGIFAWYRKQMIKRNEEYAAKAK"
     misc_feature    17544..17558
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.73"
                     /tool="antismash"
     gene            19119..20015
                     /locus_tag="HMPREF2764_RS09620"
     CDS             19119..20015
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234200.1"
                     /locus_tag="HMPREF2764_RS09620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldose 1-epimerase family protein"
                     /protein_id="WP_083306589.1"
                     /transl_table=11
                     /translation="MVIELKSEQLRVQFNSFGGALSSIKDAEGLEYLWQGDATYWSGQA
                     PVLFPICGSLREDTALYIDEKGQESKGNIPRHGLVRKKEFELVEQTDKSVTFAIEDDEN
                     SYQNYPYHFRLEITYSLTGKTVRTQYKIFNKETSKVMPYFIGGHPGFNCPLLDDEVYED
                     YYLEFEKEETCSVPRPFPETGMLDFQDRSPWLEGQKELDLSYDLFSTDAVTLDELQSRT
                     IALRSRKHDKGLKVHFAEFPNLIIWSTLNKGPFIAFEPWSGLSTSLEEGDHLEDKKNVL
                     LLEPGQVDQIGFDIEIF"
     gene            20301..20726
                     /gene="lacA"
                     /locus_tag="HMPREF2764_RS04335"
                     /old_locus_tag="HMPREF2764_04345"
     CDS             20301..20726
                     /EC_number="5.3.1.26"
                     /GO_function="GO:0050044 - galactose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590669.1"
                     /locus_tag="HMPREF2764_RS04335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF2764_04345"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_000029277.1"
                     /transl_table=11
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHVVDVTAEGQDFVDVTLA
                     VAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMITMG
                     AQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMC"
ORIGIN
        1 gaggcgattt tggcaaatat tttcgtaaat attgcgattc tttcatttgt tttggtcaaa
       61 gatggtggtg ccaaactatg gctcgtttta tcagcaattt acatgtttgt attcttaaca
      121 aacgagcaca ttgcggcgaa ctttgcttca ttcgctattg taaaattcag tgttgctgct
      181 gactcaattg ctaacttcgg tgttggaaat atgcttcgtc actggggtgt aaccttcgtt
      241 ggaaacttga ttggtggagg cctcttgatg ggtcttccat atgccttcct taataaaaac
      301 gaagatactt atgtagatta agaaaatgag cacgattgag tcgtgctttt ttcgatttta
      361 aaataaggta atagttagtt cttatatcat aatatagaaa actgatattt gtaaactata
      421 ccttaaggtg ctacaatatc cttaattaaa ctatttggag gtcgttttat gactcgtgat
      481 tttcaatttg aaactctaca actacatgct ggtcaagttg tagatccagc aactaagtct
      541 cgtgcagttc cgatttatca aacaacatcc tttgtttttg atgacacgca ggaaggtgcc
      601 gatttgtttg ccttgagaaa gccaggtaat atctatactc gtattacaaa tcctacaacg
      661 gctgcttttg aagaaagaat tgctgctctt gaaggtggtg ttggagctct tgcaacagca
      721 tcaggtatgg ccgcagtgac ttatacgatt ttggcacttg cccacgctgg tgaccatgta
      781 gtagcagcct caactattta cggtggaacc ttcaatctct tgaaggaaac ccttcctcgt
      841 tatggtatca caacaacctt tgtcgatgtg gataatttgg aagaagtgga agcagctatc
      901 ggtgacaata ccaagcttgt cttgattgaa accttgggca atcccttgat taacattcct
      961 gatttggaaa aattggctga gattgcgcat aaacaccaga ttccacttgt ttctgacaat
     1021 acctttgcca caccttactt gattaatgtc ttttctcatg gtgtagatat tgccattcac
     1081 tctgcgacta agtttatcgg tgggcatggt acaactattg gaggagtgat tgtcgatagc
     1141 ggtcgttttg actgggcagc ttcaggaaaa ttccctcaat ttgttgagga agacccaagc
     1201 taccacaatt tgagctatac tcgtgatgtg ggtgcagcag cctttattat cgctgtccgt
     1261 gtccaattgc ttcgtgatac aggtgcagcc ttgtcgccat ttaatgcctt tctcttactc
     1321 caaggacttg aaaccctttc tcttcgtgtg gaacgccatg tgcaaaatgc agagaaaatt
     1381 gttgatttcc ttgtcaacca tcctaaggta gaaaaagtca attatccaaa acttgcagat
     1441 agtccttatc atgccttggc tgagaaatac ttgcctaaag gtgtgggttc aatctttacc
     1501 ttccatgtca aaggtgggga ggcagaagca cgcaaggtaa ttgatcattt agaaatcttc
     1561 tctgaccttg caaatgtggc agatgccaag tctcttgttg tccatccagc cacaaccact
     1621 cacggtcaat tgtcagaaaa agacctagaa gcagcaggta tcacaccaaa ccaaattcgt
     1681 ttgtctatcg gacttgaaaa tgtggatgat ttgattgaag acttgcgctt ggccttggaa
     1741 aaaatttaaa gaaaaagaag ataaacagtg ggtttcgact cgctgttttt gatttttcct
     1801 taggcatgat ataatggtta aagaagtcta gaaagaggaa tgttatgaac gaaatcaaat
     1861 gccccaactg tggggaagta tttacagtaa atgaaagtca gtatgccaaa cttctgtctc
     1921 aagtgagaac agcagagttt gataaggaac tacatgatag gatgaaacag gaactggcct
     1981 tggctgagca aaaggccatg aatgaacaac agtctaaact agctcaaaaa gaccaagaaa
     2041 ttgcgcaatt acagagtcaa atccaaaact ttgatacaga aaaagaattg gccaagaaag
     2101 aggttgaaca gacaagcaac caggccttat tggctaagga caaggaagta caggccttgg
     2161 aaaatcaatt ggctaccttg cgtttggaac atgaaaatca actgcaaaag actctttctg
     2221 acttagaaaa agaacgtgat caggtcaaaa accagctcct cttgcaagaa aaggaaaatg
     2281 agctgtcttt ggcttctatt aagcagaatt acgaagccca gcttaaggca gccagtgaac
     2341 aagtcgaatt ctataagaat ttcaaagccc aacaatcaac caaggcaatt ggggaaagtt
     2401 tggaacagta tgcagagagt gagtttaaca aggttcgtag ttttgccttt ccaaatgcct
     2461 actttgagaa ggataacaag gtctctgcgc gtgggtctaa aggggacttt atctttcgag
     2521 aatgtgatga aagtggagtg gaaattattt ccatcatgtt tgagatgaaa aatgaagcgg
     2581 atggaacaga gaagaagcat aagaatgcgg acttctacaa ggaattggac aaggaccgtc
     2641 gggagaagaa ctgtgagtat gccgttttgg tgactatgtt agaagcagat aacgactact
     2701 ttaacacagg gattgttgac gtcagtcacg agtatgaaaa gatgtatgtg gttcgtcctc
     2761 agttctttat tcagttgatt ggtctcttgc gaaatgcggc gcttaattct ttgaaatata
     2821 agcaagagtt ggccttggtt cgggaacaaa atattgatat tacacatttt gaggaagatt
     2881 tggatgcctt taaactagcc tttgccaaga actacaactc tgcttcgacc aactttggta
     2941 aagcaattga tgaaatcgac aaggctatca aacgcatgga agaggtcaag aagttcctga
     3001 ccacatccga aaaccaactt cgtcttgcta ataacaagtt ggaagatgtt tcagttaaaa
     3061 aattgacccg aaaaaatcca actatgaaag cgaagttcga agcgctgaag ggagagtgag
     3121 aaagcagtgg aaaatgaatt attagtattg aatactgaag aagtaaatga gtccgaaaat
     3181 ttaaactatg atgagttaga agaactattg gaacagcaat ttacaatgga gttttctaat
     3241 cttgagaaat tagaagtaga ttgtaaagaa attagttcac cggataaatt aggagatgtt
     3301 attttggatg aaatttggaa tcaattcggg aatcaaattg gtttagatat gacaagtgat
     3361 acattactaa agcaatataa cgaaaagaac ccaaatggct atacaaaaga aattgctgat
     3421 cagattgtta aagacaaaag atatactgat gcaaataagg caatgaaaca taagcaaaaa
     3481 ttaggaaact tgaaggatga atacaccgga aaaaaattaa aaataaacga aaaagctaat
     3541 ctggatcaca tcgtaccgcg aaaacagatt tttgaaaatc catggagaaa aatagcagat
     3601 attgatcctt ctgatttagc taacaaatct gaaaatttat ctgcgactaa tgaatctctt
     3661 aataaaagta aaggcgcaaa atctaatagc gattacataa aaaataagga actaagagaa
     3721 agaaatctta gagaacaagt taaaaaagca aatgaaaaaa tagataagat gaatatctca
     3781 gatgccgaaa agcgaaatct taaagctgaa aataataaaa gattaaatga taaactagca
     3841 gctgattcaa agaagatgct taaggctgag aagacagcaa agaaagctat taataaggat
     3901 attgcaaaga aagcttctgt cagaatggcc aataaagctg gtaaagatgc tataaaagct
     3961 atgtttgttg cagctctttt tggaatgctg aaggaaatta tgaatgctct agtgaggtat
     4021 tttaaagcaa aaaaacaatc ttttgataca tttatggagg aaatgaaaaa agcacttcat
     4081 tcattttttg gtaaaatcaa agattttatt aaagtgggtg tagatagttt tgttggaagc
     4141 attgttggag aaattattgg cgcatttaac cagaaattac aaaaacttcc aaacttgatt
     4201 aaacaattat ttggttctat cagagaaagc atttcttatt tatctaaccc tgaaaatcaa
     4261 acacattcta cagcaattaa gatagctcac atttcaaaaa tcattacttc tggtttagtt
     4321 gctgtaggag caatgttttt aggagaatat tttgagcagt tcttaaataa ggtaccaggt
     4381 atgacttttg aaataaaact cctaggaaca attgctaata ttttagggat gttctttgcg
     4441 agtttactaa ctggaatctt gggagcgata atcattaacg gacttgatca atttatttca
     4501 aaaaaattaa ttgaggaaaa tcaaaagaaa caagctaata agaaaaacga attgttaaga
     4561 attcaggatg ttcaaatttt tgttgccgag caaaatgttg ctgttaagcg aaatgatata
     4621 ttcattaaga tggctaagaa ccatcaaaaa ctaagagaac ttcttggtaa tgttcaagag
     4681 gagttttcta attcaaagat tgatttcaaa cagcgattat tagctaatga aatatacttt
     4741 gatgaaaagc aaagtgaact tgaagaaatg caaagtgcat taaacgattt actataggag
     4801 aatgttatgt cagaagaatt agagattcag gttttagcaa agtctgaaag atttaatgaa
     4861 aaaaaagaag cgttgaaagc ttttagtgaa gaaattccag aacaatcaga tttaccgact
     4921 gtcccacaag acgatcctat gctaggattt attggtatgg aatatgatgt taaaggtaag
     4981 gatttaaatg ctctcaccga tgctgttcaa aatagaatga ttgaacaaaa caagcatatt
     5041 aaaaagatta ttcaggaatt taataccatt tatgaaactt tccaaatatt ggatgatgag
     5101 tatattcaaa gtatttcaaa gtctttgatt gcagccaaag aggcaaatga taaagctatg
     5161 cagggattgc acgagataga agaatatcaa actggtaata aaaaactatt agatgacgtt
     5221 tttaaccaga ataaagattt aattgatata ttgaagaaac atcataaaaa gctagaagag
     5281 ttagaacaac ttgaagagaa gcaaagtgaa attcaaattg aaattgatac tttaaaagcg
     5341 aatctaaaaa cattagtgaa aatagaaaat agttttaacg atttgcattt acaagttgaa
     5401 gaaaaacaaa ataattttaa aaatttcctt gatgaaatca ataataaatc aataacagag
     5461 agagataatc taaagttaat tgttgaaagt cttgaaacaa aactagaaga gaaacaaaaa
     5521 gagattgttt ttctaagaaa aggattctat actcttgtag tcgctgttgt tttaatagta
     5581 ttatttctat tgtttaaagg aatgtagatg attagtgaaa cttatttaaa gttgttaaaa
     5641 tcagaagtga agaaaattga tgatttaaca aatagtactt atgaattaga agtaattctt
     5701 caagatattg ttgataatgt taaaaatgct gacttagagt ttataaaacg attaggaaac
     5761 ttaactacta aagagacatt ctctacaatc aaagataagc aaactagcat attggaatta
     5821 ttgtataaat atcttggctc tagagttatt gatacaaatt atttgatttt gaaagaaaca
     5881 aataataaat catttgaagc attagcaaat gatttaaagt cattaatagg tttagaaaat
     5941 gtgaagaaag agattgaaga tctagtcgca tttaataaag ttcagcaaag tagagaaaaa
     6001 atcggtctta aaaaaacaaa tagaacgatg catatggcgt ttttaggtaa tccaggtact
     6061 ggtaaaacta ctgtggctag aatcgttggg aatatgtacc ggtcattagg aatattaagt
     6121 aaaggccact ttattgaggc aagtagaaca gacttaatag cagaatatca aggacaaacg
     6181 gcttctaaag ttaagagatt gatacaaaaa gccaaaggtg gtgtattgtt tattgatgaa
     6241 gcatatagta ttactgaaaa cgataaaagt gatagttatg gtcgagagtg tttaactgag
     6301 ttaactaaag cattagaaga ctatcgagat gatttggtgg ttattgttgc tggatatgat
     6361 gaattgatga aaaaattttt tgaatctaat cctgggttaa aatcaagatt taattatttt
     6421 attacgtttg aagattatac tgtggaccaa atgtttgaca tttttctttc acattgtaaa
     6481 aatgaagaat acattttgca tgattctgca aaagaaacat taaaaaaata tttagaatta
     6541 catagtaaca atcctgaaaa taaaaatgca aatgggcgat ttgtaagaaa tgtatttgat
     6601 aggatagtta tgaaccaagc aagaagatta gccacattat cttttgttac aaaagataat
     6661 tacattacaa ttcttgaaga agatatttca tgaatgaaat cagaaagcaa cacatgaacg
     6721 gtattatcaa tttaaaaaaa gaagcgggga tgacctcgca tgacgctgtt tttaagctgc
     6781 gtaagatttt gggaaccaag aaaattggtc atggtgggac cttggatcca gatgtgttgg
     6841 gtgttttgcc cattgcggtg ggcaaggcga cccgcatggt cgagttcatg caggatgagg
     6901 gtaaggtcta tgagggggag atcactcttg gttattcaac gacgactgag gatgccagtg
     6961 gagaagtggt cgcagagaca cctgttttgt cgcccttgga tgaaaccact gtcgatgaag
     7021 cgattgcgag tctgactggg cctattactc agattccgcc tatgtactcg gctgtcaagg
     7081 tcaatggtcg caagctttat gagtatgcgc gtgctggtca ggaagtggag cgtccagaac
     7141 gtcaggtgac tatttatcaa tttgaacgga caagtccgat ttcttatgag agcgaacttg
     7201 cgcgttttac ctttcgtgtg aaatgcagta aggggactta tatccgtacc ttatcggttg
     7261 atttaggtaa gaagctgggt tatgcggccc atatgtccca tttgacacgg actagtgctg
     7321 cagggttaca actggaggat gctcttacct tggacgaaat tgctgaaaaa gtggatgtcg
     7381 ggcaactgga ctttctccat cctcttgaaa ttggaacagg ggaccttgtc aaagttttcc
     7441 taactccaga agaggctaca gaagtgcggt ttggtcgttt tatcgagcta gaccaaacag
     7501 accaagaact ggctgccttt gagggagata cattgctagc cattctagaa aaaaggggca
     7561 atttctacaa accaaggaag gtttttagct agtttcacta gattgtgggg atagattgat
     7621 gtttccccta gactatccaa aatcagacta taaattttgc aaaaaatgtg atagaataga
     7681 cgacggataa aaaaacggag gatagcatgc aaaatagacc aatcattatc ggagtgacag
     7741 gtggttctgg tggtggtaag accagtgttt caagagccat tttatcgcat ttccctgatg
     7801 aaaagatttc catgattgag catgattcat actacaagga tcagtctcac ttgacttttg
     7861 aagagcgtgt caaaaccaac tacgatcatc cttttgcctt tgatacagac ttgatgatcg
     7921 agcagattaa ggaattgttg gcagggcgtc cggtggacat tccaacttat gactatacag
     7981 cgcatactcg gagtagcaag acctatcgtc aggagcctca agatgtcttt atcgttgagg
     8041 gaattttggt cttggaggac aagcgtctgc gcgatttgat ggatatcaag atttttgtgg
     8101 atactgatga tgatgtgcgc attattcgtc ggatcaagcg tgatatggaa gagcgtggac
     8161 gtagccttga cagtgtcatt gagcagtact taggtgtagt taaacctatg taccaccagt
     8221 ttatcgagcc gactaagcgt tatgccgata tcgtcattcc tgagggagtc agcaataccg
     8281 ttgctatcga ccttttgacg acaaaaattg caaagatttt ggaagaagcg cgaaacagta
     8341 aataatcaga tgaggaggcc tagcctcctt tttctatttt tcctttagtt tcagtaggaa
     8401 aaaggtgatt tttaagcatg tttttggtat aataataccc atggaaaagc aagaaaatga
     8461 atagtaggtg gagatggaaa agtatttatc agtaacaact ttgaccaagt atctgaaaat
     8521 gaaattcgat aaagaccctt acttggaacg ggtctattta actggtcaag tttccaactt
     8581 tcgtaaacga cctactcacc aatatttctc tttaaaagat gaccatgcag ttattcaagc
     8641 gaccatctgg tcagggattt atcagaaatt aggtttcgac ctcgaagaag ggatgaaaat
     8701 caatgtgatt gggcgtgtgc aggtctatga accaagcggt agctactcta tcatcattga
     8761 aaaagctgag cctgatgggg ttggggcgct agcgattcag tttgaacaac taaagaaaaa
     8821 actaacggaa gaaggtcttt ttcaagaacg gttcaagcaa cctcttcccc agtttgctaa
     8881 gcgaatcggt gtggtaacca gtcgcagtgg agctgttatt cgagatatta tcacgaccgt
     8941 cagcagacgc tttccaggtg ttggcattct tctctatccg accaaggtgc aaggagatgg
     9001 agctgctgag gaaatagcgc ggaatattgc gcgtgccaat caacgtgacg atttggattt
     9061 gctgattatt ggtcgtggtg ggggttctat cgaggatctc tgggccttta acgaagaaat
     9121 tgtggtacga gctatttttg aatctcgttt gccaatcatt tctagtgtgg ggcatgagac
     9181 ggatgtgacc ttggcagatt ttgtggcaga tcgacgagct gcaacgccaa cagcagctgc
     9241 tgaactagca acacctgtaa ctaagttgga tctcttgacc catttgcaaa atcaagaaaa
     9301 gcggatggca acagcagtcc gaaatgtcct atctaagaaa caagaatctt tgaaaaaatg
     9361 tagtcagtca gttatcttta gacagccaga gcgcttgtat gacggctatt tgcaacgctt
     9421 ggatcagctg caactgcgat taaaacagag tttgcgaaca cggatttctg atagtaaaca
     9481 tttagtccaa gcaaggacac accaattggt gcaattatca cctgttccca aaatccaacg
     9541 ctatcaggac cggcttgctc agttggacaa gctcctacgt agccaaatgg cgctggttta
     9601 tgacgccaag gttgcggagg tcaagcgact ttcagaagcc ttgctcatgt tggataccag
     9661 tcgaattgtg gcgcgtggct atgcaattgt caaaaaagaa gagtccgtag tcgattcggt
     9721 tgagatgttg aataaaaaag accaagtgac gcttttgatg cgagatggtc aagtagaatt
     9781 agaggttaaa gatgtcaaaa caaaagaaat ttgaggaaaa tctagcagaa ctggagacca
     9841 ttgtccaaag tttggaaaac ggtgaaattg ctctggaaga tgcgattgcg gcctttcaaa
     9901 agggtatggt cttgtcaaaa gaactccaag cgaccttaga caaggctgaa aagaccttgg
     9961 tcaaggttat gcaagaagat ggaacagaaa gtgattttga atgaagaagc aagaaaaatt
    10021 agctcttgtc gagtcggctt tggaagattt ttatggagac cagcagtttg cctctagttt
    10081 acgagagtct gttctctatt ctattcatgc tggtggcaag cgtattcgac cttttcttct
    10141 gttagaagtt ctggaagcct tgcaggtcgc tattaaacct gctcacgcac aggtagctgc
    10201 ggccttggag atgattcaca cagggagctt gattcatgat gaccttcctg ctatggatga
    10261 tgatgattac cgtaggggac gcttgacaaa tcataagaaa tttggtgaag ctatggccat
    10321 tttggctgga gatgctttgt tcctagatcc ttatgccttg atagcgcagg cagatttgcc
    10381 aagtcagata aaggttgact tgattgccaa cttatctctt gcttcaggaa gtctaggcat
    10441 ggtggcaggg caagttttgg acatggaagg tgaacaccag cacttgtcct tggaagaact
    10501 tcagaccatt catgctaata agactggaaa attactagct tatcctttcc aagctgcagc
    10561 cattatagcc gaattggaac ctgaaatgca ggcaaaactg aaaactattg gggaattgat
    10621 tgggcttgct tttcaagttc gagatgatgt attggatgtg acagctagtt ttgaggaaat
    10681 cggtaagaca ccacaaaagg atctacaggc agaaaaatca acctaccctg ccttattggg
    10741 cttggaagtg gcaattgcct tttgtaacca aaccttggat caagctaatg ccaaattaga
    10801 agaaattgcc cagcaggttc cctttgaaat agaatcgatt gtgaaagtag tagaaagttt
    10861 gagaatcaat ggctaaggaa agagtggatg tactagctta taaacagggc ttgtttgaaa
    10921 cgagagagca ggccaagcgt ggtgtcatgg ctggcctagt cgtagcagtc ctgaatggag
    10981 aacggtttga caagccagga gagaaaattc cagatgaaac cgagctaaaa ctcaaggggg
    11041 agaaactcaa gtatgtcagc cgtggtggct tgaaattaga aaaggccttg caggtctttg
    11101 atttgtcagt ggaaggagct acaacgatcg atatcggtgc ctctactgga ggttttaccg
    11161 atgttatgct gcaaaatggt gctgagttag tctttgcggt tgatgttggt actaatcagt
    11221 tggcttggaa actacgccag gacccaaggg ttgttagcat ggagcagttt aatttccgct
    11281 atgctgaaaa gactgatttc gagcaggaac cgagctttgc cagtattgac gtgagtttca
    11341 tttccctcag tctgattctt ccggccttac accgtgtgtt ggctgaacaa ggtcaggtcg
    11401 tggctttagt taagcctcag tttgaggcag gtcgtgagca gattgggaaa aatggaatca
    11461 ttcgagatgc taaggttcat caaactgtcc ttgaatctgt cactgctatg gcagttgaac
    11521 aaggtttttc agtgcttgga ttagactatt caccaatcca aggtggacat ggaaacatcg
    11581 aatttctggt atatttgaaa aaggaagagg gagcaagtaa ccaagttgcc cctgaaatag
    11641 aaaaagttgt agagagagca catagagaat ttaaagatga ataaaaaaga gagacttgaa
    11701 aaaattagaa gatttgttac ggattatcaa atcgggactc aggaagaaat tgttgagcat
    11761 ttgaaggaag caggtatttc tgctactcaa gccactgtct caagggacat caaggagctt
    11821 gggattgtta aaattccttt gaagaacaac acctatatct atgagttgcc aaaatcaatc
    11881 gtcaagagtt tgcaattggc tgaggacaat attgtgagtt ctgagttaat gggaaatatg
    11941 attaaccttg ctgtcattcc tggaaatact atttttgtga agagtcagtt ggttgaagca
    12001 ttttctgaac agatttttag ctgtctagct gatgatgatt ctatcttaat tgtagctaga
    12061 acagcagagg cagctgagga aattgttgaa caagtcaaaa aatggtaggt cagtatgtta
    12121 cttgaaattt cgataaaaaa ctttgccatt attgaggcga tttcgctcaa ttttgaaaag
    12181 ggtatgactg ttttaaccgg ggaaacgggt gctggaaagt ctatcattat cgacgctatg
    12241 aatctcatgt tgggggctcg tgcaacgaca gacgttattc gtcatggtgc gccaaaggca
    12301 gagattgagg ggcttttttc ggttgaaaat agtcgccttt tacaggaact ttttgaagag
    12361 caaggtttag aattgggtga tgagattatc atccgccggg aaattttgca aaatggtcgt
    12421 agtgttagtc gcgtgaatgg tcagatggtc aatctttctg tcttgcgtgc cattgggcaa
    12481 caccttgtgg atatccatgg tcagcatgac caagaggagt taatgcgtcc tcaactgcac
    12541 atccagatgt tggatgagtt tggtgatgct actttcttgg acttgaagga gacctatcag
    12601 acgagctttg atgcctatcg caaaatgcgc aagcaggttt tggaagtcaa gaaaaaccag
    12661 caggaacata aggctcgtat tgagatgttg gaatttcaaa tggcagagat tgaggcagcg
    12721 aacttacagg ctggtgaaga cttagctctc aaccaagaac gagagaaact tctcaaccat
    12781 aaaaatatag cggatacgtt gaccaatgcc tatagcatgt tggacaatga agacttttca
    12841 agtctggcca atgttcgttc agccatgaat gacatggaaa gtgtcgaaga gtacgaccct
    12901 gaataccgtg aaatttcaag ctctctgtct gagacctact atgtcttaga agatataagc
    12961 aaacgtttgg aagcaatcat tgaggacctt gattttgatg gtaatcgtct catgcaggtc
    13021 gagaatcgtt tggatctcct tcataccatt acacgtaagt atggtgggac tgttgatgat
    13081 gtcttgcttt attttgccaa gattacggaa gaatacaatc tcttgacagg caataatctc
    13141 tcgtctgagg acatggaagc ggagctcaag aaattggaag ttattcttgt cgacttggca
    13201 ggtcagcttg catctgctcg tcatgatttg gctcagcagc ttgaagctga gattaaacaa
    13261 gaactgcaag acctttatat ggaaaaagcc cagtttcagg ttcgttttag caagggcaaa
    13321 ttcagtcgtg agggaaatga aatggttgag ttttatattt caaccaaccc tggtgaagac
    13381 tttaaaccct tggtcaaggt tgcatctggt ggggaattat ctcgtctcat gctagccatt
    13441 aagtctgcct tttcacgtaa agagggcaag acaagtattg tctttgatga ggtggatacg
    13501 ggagtttcag gccgtgtagc tcaggccatt gcacagaaga ttcataagat tggccagcat
    13561 ggccaagtct tagcaatctc tcacctacca caagtaattg ccatcgcgga ttatcaattc
    13621 tttattgaga agattagtga tgagcattct acggtgtcga cggttcgtct cttgactata
    13681 gaagagcgag tagaggaagt agctaagatg ttggctgggg aaaatgtaac tgaagctgcc
    13741 cttacccaag ccagagaatt attgcaaacg aggatgaaat aaatgacaga ctattatgta
    13801 attggagatg tccatggaaa agcaggtatg ctggaagacc ttctcaaaac ctgggatggt
    13861 cagaccaaat tgctctttct aggggatttg attgaccgcg gtgaagatag tcgccgtgtt
    13921 cttgaaatgg ttaaggactt agtggacaat caaggggcta tctgtctatc aggaaaccac
    13981 gagtatatgt ttttgacttg gctcgataac ccagaagaaa gctatgacca ttatcgtcgc
    14041 aatggtggag atacaaccat taactctatc ctaggtcgtc ccttggatgc accggttgat
    14101 ggggtagaag atgccaagcg tgttgctact gaagaggcag acttggtcga atttattcgt
    14161 caaatgccat ttgtggtaga gacagacaag tatatctttg ttcacgcagg tattgatttg
    14221 accttggatg actggcatga aaccacagat tataaaaaag tctggctcag aaaaccattc
    14281 cacgaagcag aaaatcatac tgggaaaacc attgtctttg gacatacacc ggtttatggt
    14341 ttgctgaagc aagagcgtgg tactgctgag ctttggacta cagaagatgg caagattgga
    14401 atggatggag gagctgttta tggtggtgtc cttcatggga ttgtctttac agaccaagga
    14461 atgacagaac accactttat cgaaaatgac ggctttgttg ctgaagatta gtactcctgg
    14521 cagggtatgg tcttgtcaaa atgtcaaaaa caatttataa taaatagata ccctgaaagg
    14581 aagagaatca tgaacttaga agaattgaaa aaacgacagg agaagatccg taacttctct
    14641 attatcgccc atattgacca cgggaaatcg actctagcag accgcatttt ggaaaaaaca
    14701 gagaccgttt caagtcgtga aatgcaggcc cagcttttgg atagcatgga tttagaacgg
    14761 gaacgtggga ttaccattaa gttgaatgcc atcgagctga attatactgc aaaagatggg
    14821 gaaacttata ttttccactt gattgacacg ccggggcacg ttgactttac ttatgaagtt
    14881 tcacgttcac tcgctgcctg tgaaggagct attttggtgg tcgatgctgc tcaagggatt
    14941 gaggctcaaa cccttgccaa tgtgtatcta gccttggaca atgatttgga aatcatgcca
    15001 gtcattaaca aaattgacct tcctgctgca gatcctgagc gcgtgcgtac agagattgaa
    15061 gatgtgattg gtttggatgc cagtgaagca gtcttagcat cagctaaagc tggtattggt
    15121 atcgaagaaa ttctcgagca aattgtagaa aaagttccag caccaacggg tgatgtgacg
    15181 gcgccactta aggccttaat tttcgactca gtttatgatg cttaccgtgg ggttattctc
    15241 caagtgcgtg ttatggatgg agtggtcaaa cctggcgata agattcagct tatgagcaat
    15301 ggcaagacct ttgatgtgac cgaagtcggt atttttactc cgaaagcagt tggtcgtgat
    15361 ttccttgcga ctggtgatgt tggttatatt gcagcatcta ttaagacggt tcaggatact
    15421 cgtgtgggtg atacagttac tttggcaacc aatcctgcgg ctgagccatt atatggctac
    15481 aagcagatga atcctatggt ctttgcgggt ctctatccta tcgagtcaaa caagtacaat
    15541 gacctacgtg aagcccttga aaaattgcaa ctgaatgatg ctagtctcca atttgaacca
    15601 gaaacatctc aggcacttgg atttggtttc cgttgtggtt tccttggact tctccatatg
    15661 gatgttatcc aagaacgttt ggaacgtgag ttcaacatcg acctcatcat gacagctcca
    15721 tccgttatct ataaggttaa tttgaccgat ggtgagtcta tggatgtgtc aaatccatct
    15781 gagttcccag atcctaccaa gattgcgacc attgaagagc cttatgttaa ggcgcaaatc
    15841 atggtgccgc aagagtttgt tggagcagtc atggaattag ctcagcgcaa gcgtggggac
    15901 tttgtgacga tggactatat tgatgataac cgtgtcaatg ttatctacca aattcctctt
    15961 gctgaaattg tctttgactt ctttgataaa cttaagtctt cgacacgtgg ttatgcaagc
    16021 tttgactacg aattgtcaga gtatcgccca tctaagctgg tcaaaatgga catccttctc
    16081 aatggagaca aggtggatgc cctcagcttt atcgttcaca aggactttgc ctacgaacgt
    16141 ggaaaactca tcgttgataa acttaagaaa attatccctc gccaacaatt tgaggttcca
    16201 attcaagcag ctattggaca caagattgtg gctcgtactg atatcaaggc ccttcgtaag
    16261 aacgtacttg ctaaatgtta tggtggtgac gtttctcgta agcgtaaact gcttgaaaaa
    16321 caaaaagctg gtaagaaacg catgaaagct atcggatcag tagaagttcc acaagaagcc
    16381 ttccttagcg tcttgagcat ggatgaagaa taagttatca taattgtttt tcttgttcac
    16441 aggaaactta cataagaatc aatagtaaaa caggcttaaa taggcctgtt ttttgcattt
    16501 ataataggat taaatcgttt agagtgtttg ttttaagtgt ttgttttggt tgtaaagata
    16561 aaaaataaac aaaataatca aaaaaaggac aaaaaacaac aaaaaattat tgacaacgat
    16621 ttcatatagt gttatactta tagcataaag ttaatggaaa gaagggaaaa ccttatggga
    16681 ttagatcatt tctttgacaa aaaccttgtg ttttgcttag aagcggataa tcaagaacat
    16741 ctctttgatc aggttgcaac tttattggaa gaacgagaaa tcgtaactcc aacttatcgt
    16801 gaagccttga tcacgcgtga aaagtcattt ccaactggct tagatatgga atttttgggt
    16861 aaggatttgc cgaatgtggc tattcctcat actgatattg ttcataatct agctgaaaaa
    16921 gttgtggtcg ttcgattaga aaaaccagtg actttccaca atatgattgt gccagataag
    16981 gaagtagaag tatccttgct cttctttatc attaataact caagttcaag tcaaaccaat
    17041 attcttgctc agttgatgga cttctttact ggaaatggtc atcttgaaga cctatcaaaa
    17101 atttctgaac cagaagccct ctatacttat attgctgaag caattgctta atcttgtcta
    17161 ttaaaaatat taaatcggag gaaatccata tgattaaaat tcttgctgcc tgcggtgcag
    17221 gtgttaactc aagccaccaa attaaaagtg ctcttgaaga agaactttca aaccgcggtt
    17281 ttgatgttca ctgtgatgca gttatggtaa aagacgttaa cgaagatctt atcaaaggtt
    17341 atgacatctt cacaccaatt gctgctacag accttggttt tgacccaggt attccagtta
    17401 tcgaagctgg accaatctta ttccgtatcc cagctatgag tgctccagta tttgacaata
    17461 ttgaagcagc tatcaaagaa cacggattaa gctaatttta atttgttaac attcatataa
    17521 ctataaaaag ggaggaacta ttatggatgt cattatcaat ctggccaacg atatctttaa
    17581 acctatcttg gctatgggtg gccctatcat catgctgatc attttgacag tgttggccct
    17641 actttttgga gtgaaattct ccaaagcgct tgaaggtggt atcaaacttg ccatcgctct
    17701 tacaggtatc ggtgccatca tcggtatgtt aaatggtgct ttctcagcat cacttgcaaa
    17761 attcgttgaa aacactggta ttcaattgaa catcaccgac gttggttggg caccacttgc
    17821 taccatcact tggggatctg cttggacact ttacttcttg cttgtaatgt taattgtcaa
    17881 cgttgtgatg cttgcaatga agaaaacaga cacacttgat gtcgatatct tcgatatctg
    17941 gcacttgtca atcactggtc ttttgatcaa atggtatgca gacaacaatg gtgtaagcca
    18001 aggggtttca ctcttcatcg cgacagcagc agttgtactt gtaggtattt tgaagatcat
    18061 caactctgat ttgatgaaac caacattcga cgaccttctt aacgcaccaa gttcatcacc
    18121 aatgacttca actcacatga actacatgat gaacccagtt atcatggtct tggataagat
    18181 ttttgataaa gttttgccag gtcttgataa atatgacttt gacgctgcaa aattgaacaa
    18241 gaaaatcggt ttctggggat ctaaattctt catcggtttc attcttggta tcgttattgg
    18301 tttgatggga actccacatc cagttgctgg agtagaagat gcatcttcat gggaacttgt
    18361 tattaaaggt tggttgtctc ttggtttgac agccggtgta gctttggaac tcttctcact
    18421 tatcggttca tggttcatcg cagccgtaga accactttca caaggtatta caaacgttgc
    18481 tactaaacgt ttggaaggac gtaagtttaa catcggtcta gactggccat tcatcgctgg
    18541 tcgtgctgaa atctgggctt gtgcaaacgt acttgcacca attatgttga ttgaagctgt
    18601 gcttctttca aacgtcggaa atggtatctt gccacttgca ggtatcatcg ctatgggtgt
    18661 tactccagct ctcttggttg taacacgtgg taaattgctc cgtatgatta tcttcggaac
    18721 actcttgttg ccactcttcc ttctttcagg tacacttatc gcgccatttg caacagaact
    18781 tgctaaaggt gtaggtgcct tcccagaagg tgtgagccaa actcaattga tcactcactc
    18841 aactcttgaa ggaccaatcg aaaaacttct tggttggaca attggtaaca ctacaactgg
    18901 tgatatcaaa gcaatccttg gtgctgtagt cttccttgta ttctatatcg gtatctttgc
    18961 atggtacaga aaacaaatga tcaaacgtaa cgaagagtac gcagcaaaag caaaataatg
    19021 cgctcctata aaatgtaaat tgttaaagct aggttgtcga catccattag gagtgacaac
    19081 ctagtttttt ataaactatc aagaaatcgg agaaaataat ggtaattgaa ttaaaatcag
    19141 aacaattaag agttcaattt aacagttttg gtggggctct ttcttctata aaagatgctg
    19201 agggactgga gtatttgtgg caaggagatg ctacatattg gagtggacaa gctcctgttc
    19261 tctttcctat ttgtggttca ttaagagagg atacagccct ctatatagat gagaagggac
    19321 aggaaagcaa aggaaacatt cctcgtcatg gtttggttcg taagaaagaa tttgaattag
    19381 ttgaacagac agacaagagt gtaacttttg caattgaaga cgatgagaat agctatcaaa
    19441 actatcctta tcatttccgc ctagaaatca cttatagcct tactggtaaa acagtacgga
    19501 ctcaatacaa gattttcaat aaagaaacta gcaaggtcat gccttacttt attggtggac
    19561 atccaggatt taattgtcct ctgcttgatg atgaagtcta tgaagattat tatctagagt
    19621 ttgagaaaga agagacttgc tctgttccac gtcctttccc agaaacaggt atgttggatt
    19681 tccaagatag aagtccatgg ctagaaggtc aaaaagaatt agacctcagc tatgatcttt
    19741 tcagcacaga tgcagttacc ttagatgaat tgcaatctag aacaattgcc cttcgttctc
    19801 gtaaacatga taagggattg aaagtccact ttgcagagtt tccaaacctc attatctggt
    19861 caactttgaa taaaggtcct ttcattgctt ttgaaccatg gtctggcttg tcaacatccc
    19921 ttgaagaagg agatcatcta gaagataaga agaatgttct tctcctagaa cctggtcaag
    19981 tggatcaaat tggttttgat atcgaaattt tttagattaa aaaacacaaa aacaaacatt
    20041 aactgttgac tttttcgtaa aataggagta tattatgttt gtaagcaaca aatgatgttt
    20101 gtaacaaaca aacaatcact tgttatattc tcttgcgtgg agaaggatta tttctaggga
    20161 actggtttcc taaacttgaa taaggtgtca ttcatctcat tcaatccaat ttgtcaataa
    20221 actgctagaa aactttttgt aggtaaactg ctaactgtta aagtttttac tagcctagaa
    20281 aaataaaagg agtatacaat atgtctattg ttatcggtgc agatgctgca ggtttgagat
    20341 tgaaagaagt tgtgaaagac ttcttggaaa aagaaaactt ccacgttgtg gatgttacag
    20401 ctgaaggtca agactttgtt gatgtgactc ttgctgttgc tgcagaagta aacaaagaag
    20461 aacaaaacct tggtatcgtg attgatgctt acggtgctgg tccatttatg gtcgcaacta
    20521 agatcaaagg aatggttgct gcagaagtat ctgacgaacg ttcagcttat atgactcgtg
    20581 gacacaacaa ctcacgtatg atcactatgg gcgcacaact tgtcggtgat gaattggcta
    20641 aaaacatcgc taaaggattt gttaacggta aatacgatgg tggacgtcac caaattaggg
    20701 tcgacatgtt gaacaaaatg tgctaatact cttcaaaaat caagataatc tgttgtcagc
    20761 tcactttagc taacctcagt tatgcttgca gcacgcttcc taagctaatc ttgatttttc
    20821 ttgagtaggg ataaatgata ttagatttat ataattaatc ggagggaata actaat
//
