LOCUS       NZ_CP017599            10939 bp    DNA     circular CON 16-JAN-2024
DEFINITION  Moorena producens PAL-8-15-08-1 chromosome, complete genome.
ACCESSION   NZ_CP017599
VERSION     NZ_CP017599.1
KEYWORDS    RefSeq.
SOURCE      Moorena producens PAL-8-15-08-1
  ORGANISM  Moorena producens PAL-8-15-08-1
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Oscillatoriales; Oscillatoriaceae; Moorena.
REFERENCE   1  (bases 1 to 9673108)
  AUTHORS   Leao,T., Castelao,G., Korobeynikov,A., Monroe,E.A., Podell,S.,
            Glukhov,E., Allen,E.E., Gerwick,W.H. and Gerwick,L.
  TITLE     Comparative genomics uncovers the prolific and distinctive metabolic
            potential of the cyanobacterial genus Moorea
  JOURNAL   Proc Natl Acad Sci U S A 114 (12), 3198-3203 (2017)
   PUBMED   28265051
REFERENCE   2  (bases 1 to 9673108)
  AUTHORS   Leao,T., Castelao,G., Korobeynikov,A., Monroe,E.A., Podell,S.,
            Glukhov,E., Allen,E., Gerwick,W.H. and Gerwick,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-OCT-2016) Scripps Institution of Oceanography, UCSD,
            9500 Gilman Dr, La Jolla, CA 92093, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2016
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 98.0x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 04:55:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,406
            CDSs (total)                      :: 8,335
            Genes (coding)                    :: 8,097
            CDSs (with protein)               :: 8,097
            Genes (RNA)                       :: 71
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 238
            CDSs (without protein)            :: 238
            Pseudo Genes (ambiguous residues) :: 0 of 238
            Pseudo Genes (frameshifted)       :: 87 of 238
            Pseudo Genes (incomplete)         :: 150 of 238
            Pseudo Genes (internal stop)      :: 79 of 238
            Pseudo Genes (multiple problems)  :: 69 of 238
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:37:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3726609
            Orig. end                         :: 3737548
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017599.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerwick Lab Culture
            Collection, UCSD, SIO.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10939
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="13"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10939
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10939
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5939](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5939
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(204..1070)
                     /locus_tag="BJP34_RS13885"
                     /old_locus_tag="BJP34_13885"
     CDS             complement(204..1070)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017829.4"
                     /locus_tag="BJP34_RS13885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP34_13885"
                     /product="DUF928 domain-containing protein"
                     /protein_id="WP_070392860.1"
                     /transl_table=11
                     /translation="MKNTANIINLFGRTTWACTTSILIVLLFCTLTPKPSYSQGLQSVN
                     GQVADSNHNSSETQNSSQNSSAKRSRLRFIPPTDSAPRKSNGSGSRGGCEQLPSELVTL
                     LIPSKEVAAQTISGHPRFLWYLSEPVDVPIVFTLVDTVEHQTIFEKKIDSAEVGMISVE
                     LPENSPQLIANPPGLEAKDRNIYMWFVTLECDRENPSNNSYHTSWIERVSPPPELEQKL
                     AAVAANTNSSTSELLHQQAIIYAEAGAWFDALDALYQAQAANPNDSSIRADFIALLEQV
                     GLGSVAQ"
     gene            complement(1391..3643)
                     /locus_tag="BJP34_RS13890"
                     /old_locus_tag="BJP34_13890"
     CDS             complement(1391..3643)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008181409.1"
                     /locus_tag="BJP34_RS13890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP34_13890"
                     /product="adenylate/guanylate cyclase domain-containing
                     protein"
                     /protein_id="WP_070392861.1"
                     /transl_table=11
                     /translation="MWQPLKQQLWEWRGVLITTPVVAGIAIAFRLLGWLQPYELAALDQ
                     YFCWRPKEPTDERIVIVAMSEADLKGAGRWPITDRMLARLLDKIKAQNPAAIGLDLYRD
                     FPVEPGHGELRRVFETTPNLVGIEYIDQDNPDNSVAPPPILSERGLVGANNVVNDMDGI
                     LRRSLLSLKINDGVQPSFSMLLAEIYLESKNLFPEPLQQDPRIFQWGKAMFRPLASNDG
                     GYVGIDDGGYQIFLNYRGAAGTFPMVTMTDILEDNIPDDLINDSIVLIGATAVSLNDFF
                     YTAYSNDTTIRESTAGVEVQANMVSQIISAVENGRPLLKTWSEPVEILWIVGWSVVGAI
                     LTWKWRYLGGLGGLSLRRTAITVVATGTLFGSTYGAFLGGWWLPVIPPLLALSGSAIAI
                     TAYVASTVKEIRHTFGRYLTDQVVADLLENPDKQKLGGENRKITILTSDLRGFTAISER
                     LHPQEVVKILNIYLGHMADVITAYQGTIDEFMGDGILVLFGALTLQEDDAHRAVACALA
                     MQLAMTSVNEEIEQLGYPKLEMGIGINTGVVVLGNIGSEKRTKYSVIGSAVNLAYRIES
                     YTTGGQVMISSSTLEETGECLRIDGQIQVKPKGIKQPITIYEVGGIRHNYNLFLPKQQE
                     TFFQVNQKIELQFNYAFLDGKHISNSVYTGRLVEISSKGAKLRANSSEISAIPEALSNI
                     KLNLLDPDNVNQPSEDIYAKVLEKTAEPGSFYIRLTAVPPEISAKLESIYQSVIRN"
     gene            4267..4668
                     /locus_tag="BJP34_RS13895"
                     /old_locus_tag="BJP34_13895"
     CDS             4267..4668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008181410.1"
                     /locus_tag="BJP34_RS13895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP34_13895"
                     /product="DUF2282 domain-containing protein"
                     /protein_id="WP_070392862.1"
                     /transl_table=11
                     /translation="MELNQHCFRLILSTDLRVSSDIRESYVMKDMKKTVMVSAALTSVL
                     ALGLGVASENALAGKEGMEKCAGIVKAGQNDCGTSKHDCGGMAKVDSDPEEWIYVPEGT
                     CKKIVGATIVGEPTSSQETEKPTESAQAN"
     gene            5001..5939
                     /locus_tag="BJP34_RS13900"
                     /old_locus_tag="BJP34_13900"
     CDS             5001..5939
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008181411.1"
                     /locus_tag="BJP34_RS13900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP34_13900"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_070392863.1"
                     /sec_met_domain="DUF692 (E-value: 6.5e-93, bitscore: 309.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHLPSASINGAGIGLRSAHYQDILTHKHTIPWFEVLLDNYLTS
                     QGLPLHFLEKVRQNYPVTLHGVGMSLGSTDPLDLEYLTNLKELAQQIEPAYISDHLSWI
                     SVNGHYLNDLIPLPYTEAVMEHVAQRILQAQEFLGCRILIENPSAYVSFTDSTMPEWVF
                     IQQLLEKADCYLLLDVNNLYVTATNQGFDPLDYLNTIPATRVKQIHLAGYEEREDYLYD
                     THGYPVHPPVWQLYQATLERFGPVPTLIEWDTDIPAFEVLMTQASKAQEYLDQVSITKG
                     TGNREQGTGSRESGVGSRESGTSEQKLSQFI"
     gene            6283..7062
                     /locus_tag="BJP34_RS13905"
                     /old_locus_tag="BJP34_13905"
     CDS             6283..7062
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008181412.1"
                     /locus_tag="BJP34_RS13905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP34_13905"
                     /product="DNA-binding domain-containing protein"
                     /protein_id="WP_070392864.1"
                     /transl_table=11
                     /translation="MELRTLQQLFYDAVFENNPASTQTLAQHIKAAKQLTPAEGLAIYR
                     SSVLGNLSQTLMSIYPVCCCLVGEKFFEGTARSYIQRFPSLSMDLGDYGEHFPDFLANF
                     EPAKQLPYLPDVARLEWHWHRVFNGEEATKLDVQALSTVPQDKWGELIFHLPKNSVLIE
                     SAYPIHRIWEVNQPEYEGDQQVNLDEGGIQLFLWRNGYDMRIELPTKAEWQLLKAFQGD
                     NRFEAICQDLAADELAIDVASELPQFVQRGWIARFSI"
     gene            7329..8480
                     /locus_tag="BJP34_RS13910"
                     /old_locus_tag="BJP34_13910"
     CDS             7329..8480
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1192: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008053233.1"
                     /locus_tag="BJP34_RS13910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BJP34_13910"
                     /product="RNA-guided endonuclease TnpB family protein"
                     /protein_id="WP_070392865.1"
                     /transl_table=11
                     /translation="MAPNHSYTTKLKLNNRQKTLMAKHAGFSRWVYNWGLGMWKDAYNE
                     GLKPNIKTLKRLFTNHVKPEYPWMRELSSKVYQYAFINLGEAFKRFFKGWGKYPRFKCK
                     GKNDRFTIDNSGRPIRLGGLIHNLPFLKQVRTFEPLPDCLTKKVTIYKKAGEWYISFSM
                     EKTFEPTLKERERVGVDFGIKTLAVLSSGVEFEGLKPYRNAQRKLSRVQRKLSKKERGS
                     QNYLKTQLEVQKFHHRVANLRKDYLQVRPVANLIRQRKAHLYKMTTYIAKNHGEVVIED
                     LNVSGMMANHKLAKAIGDLGLHEARRQLTYKCERYGTKLVVADRFFPSSQLCSNCGNQQ
                     PMPLSQRVYSCDCCGNKIDRDWNASVNLERYNEYGSTRKPVEG"
     misc_feature    9821..9836
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     misc_feature    10258..10269
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
ORIGIN
        1 tgcgcgactt cctcgcagtc atatagcgct acgcttagcg tcagaagtca gaagtcagaa
       61 gtaaacactg ataccaagtt gcggtcaaac atacaacttt ctcttccccc aatttcccca
      121 tctccctatc tccccatctc cctatctccc tatctcccta tccaagcaat ctactatctt
      181 tgaatacaac tcggtatgac cgactactgt gccacactac ccaatcccac ttgctccaac
      241 agagcgataa aatctgctcg aattgaggag tcattgggat tagcagcttg agcctggtaa
      301 agggcatcaa gggcatcaaa ccaagcccct gcttcggcat agatgattgc ttgttgatgc
      361 agtaactcag aggtggagct gttggtattt gcagcaacag ctgctagctt ttgctctaat
      421 tctgggggtg gtgatacccg ctcaatccag ctcgtatgat aggaattgtt agacgggttt
      481 tcgcgatcgc attctagggt aacaaaccac atgtatatgt tcctgtcttt tgcctccagt
      541 cctggtgggt ttgcgatcag ttgtggactg ttttccggaa gttctactga gatcatccct
      601 acctcagcgg agtcaatctt tttctcaaat attgtctggt gttctactgt gtccaccaag
      661 gtaaatacta ttggtacgtc tacaggctcg gacaaatacc ataaaaatct aggatgacca
      721 gatatagttt gtgcagcgac ttcctttgaa ggaattaaca gcgtcaccaa ttcacttggt
      781 aactgctcac acccgcctcg tgaaccagac ccattactct ttcgaggagc gctatcggtt
      841 ggtggaataa atcgtaagcg tgagcgttta gctgaactat tttgggaact attttgggtt
      901 tcagatgagt tatgattaga atctgccacc tgaccgttga cagattgcaa cccttgagaa
      961 tagcttggtt taggggtgag tgtgcaaaac agcagtacaa tcaggattga tgttgtacat
     1021 gcccatgttg tacgcccgaa taaattaata atgttagcgg tatttttcat cagtttattg
     1081 aattattaaa ctagaataga caattacaag aattagcatt aatccttagt aaagcctgag
     1141 tttaagctta attgtttcag agatataatt ttttggtgcc atggatttct aatctcaaat
     1201 cccgctgact agttttcctg tggcagggaa acgatcactc gtattatccc gcaaccaaca
     1261 cagggttttt ctagcagcga ttaactagac ttgaaattag accaaattgc ctggaaccag
     1321 gtaacttttt atacccgaaa cccttgagcc aactcaacgg tgactaaatt agacttcaca
     1381 gaacttagga tcaattcctg attactgact ggtatataga ttctagtttt gctgatatct
     1441 ccggagggac agcagttaac cggatgtaaa aacttcccgg ttctgctgtt ttttctaaaa
     1501 ccttggcgta gatgtcctca ctgggttggt tcacattatc tggatcgagt aagttgagct
     1561 taatattact gagtgcctca gggatagcag agatttcgct gctgttagca cgaagcttag
     1621 ctcccttact tgaaatctct actaaacgtc cagtgtagac ggaattactg atatgctttc
     1681 catctagaaa agcataatta aattgtagct caattttttg gttaacctgg aaaaacgttt
     1741 cttgctgttt gggtaaaaat aggttataat tatgccgaat tccacccact tcatagatag
     1801 taattggctg tttaattccc ttgggtttta cctgtatttg accgtcaatt cttaagcatt
     1861 cgccagtttc ttccaaagtg gaagaagaaa tcataacttg accaccagtt gtataagatt
     1921 cgatccggta agccaggtta acggcgctgc caatgacact atatttggtg cgtttttcgg
     1981 aaccaatatt cccaagcaca accacaccgg tattgatacc gatgcccatt tccagttttg
     2041 gatagcccaa ctgctcgatt tcttcattga cactagtcat ggctaactgc atcgctaggg
     2101 cacaagccac tgctctgtgg gcatcatcct cttggagggt gagagcacca aaaagcacta
     2161 aaatcccatc ccccatgaac tcgtcgatag ttccttgata agcagtaatc acatccgcca
     2221 tgtgacccaa atagatgttg aggattttga ccacctcttg gggatgtaac cgttctgaga
     2281 tggcagtgaa gcctcttaaa tcagaggtca agatcgtgat tttccggttt tcacccccga
     2341 gtttttgttt gtctgggttc tccagcaaat ccgccaccac ttggtcagtt aggtaacgtc
     2401 caaaggtgtg acgaatctct ttaacagtgc tagcaacgta agctgtgatg gcaattgcag
     2461 acccacttaa ggctaacaat ggcggtatca ccgggagcca ccaacccccc aaaaacgctc
     2521 cataggtact tccgaataat gtccctgtgg ccaccacggt aatcgcagtt ctcctcaatg
     2581 acagccctcc gagaccccca agatagcgcc atttccaagt tagaatcgca ccaacgacag
     2641 accagcctac aatccacagg atttccacag gctcagacca ggttttgagc aagggacgac
     2701 cattttccac agcactaata atttggctga ccatgttagc ttggacttcc acaccagccg
     2761 ttgactcccg gatggtagtg tcattactgt aggcggtgta gaaaaagtca tttaaactga
     2821 ccgcagttgc accaattaaa acgatggaat cattgatcaa gtcatctgga atgttatctt
     2881 ccagaatgtc ggtcatggtt accatgggga aggttcccgc tgctccgcga tagttcaaga
     2941 aaatctggta accgccatca tcgattccca cataaccgcc atcattgctg gccaaagggc
     3001 gaaacatggc cttgccccac tggaaaattc tgggatcttg ctgtaatggt tcaggaaaaa
     3061 ggttttttga ctctagataa atctccgcta ggagcatact aaaggagggc tgtacgccat
     3121 catttatttt caaagaaagt aagctgcgcc gcaggatacc atccatatca tttacgacat
     3181 tattggcacc tacgagacca cgttcactga gaatcggtgg aggagccacg gaattgtcag
     3241 ggttgtcttg atcgatgtat tcgataccaa ctaagttggg tgtggtttca aacaccctgc
     3301 gtaactcacc atgaccgggt tcaactggaa aatcccgata caggtcaaga ccaatggctg
     3361 caggattttg agctttgatt ttgtctaaaa gtcgggcaag catccgatca gtgattggcc
     3421 accgtccagc accctttaaa tctgcctcac tcatagccac aatcacaatc cgttcatctg
     3481 taggttcctt cggacgccaa caaaagtatt ggtcgagagc cgctagttcg taaggctgta
     3541 accagccgag tagcctgaat gcgatcgcaa ttccagccac caccggtgta gtaattagaa
     3601 caccgcgcca ttcccatagt tgttgtttta gtggttgcca catcttacat ttttcaagtg
     3661 ggtgaggtac ttttgttatt ggttttaggg aacagggagc agggagcagg gagcagggag
     3721 cagcggttct cggagcaggg cagaaacttc agatgtacct cacgcttacg aggaaactat
     3781 tattacggtt gaacctcaaa aaatggtttc ttctggaaag ggtgattgac aatgatagag
     3841 ctatgagtca ctacaagagc attagtgggt gcatctcact ttggcaaaaa cacttagcac
     3901 aatagaaggc taatatcatg ttatgatagt taccctgtct tgatgcagtc gctcatgggg
     3961 gaaaccacgg cagtcgctca tgggggagac ccccaagacc gcgctgcctt cccaagaccg
     4021 cgctgcatcg cttaataaaa atctccccca tctccccatc tccccatctc cccatctccc
     4081 cacacttccc acacttgcgg gagtgataga tttacaacaa aaagctgata gctgatagct
     4141 taagtccttt gtttccaaag gttttcaaat tttctatcct attttaataa ctttctcagg
     4201 gttatctcat acttttcaaa gactcggtta agataggtta aatactttaa ataataatta
     4261 catagattgg aattaaacca acactgtttt aggttaattc tgtctacgga cttacgagtc
     4321 agttctgata ttcgggagag ttatgtcatg aaagatatga aaaaaactgt aatggtgagc
     4381 gctgccttga ctagtgtctt ggctctaggt ttaggtgtag catctgaaaa cgccttggcc
     4441 ggtaaggaag gaatggaaaa atgtgctggt atcgttaagg cgggtcagaa cgattgtggc
     4501 accagcaagc atgattgcgg cgggatggct aaggtagata gcgatcccga agagtggatc
     4561 tacgttcctg aaggcacttg caaaaagatt gttggtgcca cgattgtagg agaaccaacc
     4621 tccagccagg aaactgaaaa gccaaccgag agtgcgcaag ccaattaaac caagctatca
     4681 gcaggctggg cactcagcta tcagcttatg aatcatggct gagtagggtt atgtacacag
     4741 atccccccta acccccctta agaaaggggg gaattagatt cagctgagta gggttatgta
     4801 taccgatccc ccctaacccc ccttaagaaa ggggggaatt agattcagct gagtagggtt
     4861 atgcataccg atccccccta acccccctta agaaaggggg gaattagatt cagctgaaat
     4921 gcttcgtgct gataccttac cactaccatg gataaatcct aaaaataatg ccatgaaaac
     4981 aatgtcatga aaacaatgct atgacaactc accttccttc agcttcaatt aacggtgctg
     5041 gaatcggttt acgctccgcc cattatcaag atatccttac tcataaacat actatacctt
     5101 ggtttgaggt attattagat aattatttaa cgtctcaggg tttaccactc cactttttag
     5161 aaaaagtccg ccaaaactat cccgttacgt tacatggcgt cggtatgtct ttggggtcaa
     5221 ccgacccttt agatttagag tatttgacaa atttaaaaga gttagcccag cagattgaac
     5281 cagcatacat ttccgatcac ctatcctgga tttccgttaa cggtcactat cttaacgatt
     5341 taattcctct tccttatacc gaagcggtga tggaacatgt agcccaacgg atattgcaag
     5401 ctcaggaatt tctaggttgt cgcattttga tagaaaaccc atcggcttac gtgagtttca
     5461 cagattcaac catgccagaa tgggtattta ttcaacaatt gttagaaaaa gcagattgtt
     5521 acttgctgct agatgtcaac aatctttatg tcactgctac taatcaagga tttgaccccc
     5581 ttgattacct gaatacaata ccagcaacca gggtcaaaca aattcactta gcagggtatg
     5641 aagaacggga agactatcta tatgataccc acggttatcc tgttcatcct ccagtgtggc
     5701 aattgtatca agcaacatta gagcgctttg gtccagtgcc tactctgatt gaatgggata
     5761 ctgatatccc agcttttgag gtattaatga ctcaagctag taaagctcag gagtatttag
     5821 atcaggtaag tataacaaag ggaacaggga acagggaaca gggaacaggc agtcgggagt
     5881 cgggagtcgg gagtcgggag tcgggaactt cggaacaaaa attatcacaa tttatttagg
     5941 atacctatat atagcatttc taaataggtc atgaacaatc ttgctgattt ctcatatagc
     6001 actacccatt aaggttagga cattaataca agctgaaaag cttttgtagt aaactttagc
     6061 atgcatgcct cttgcctctt gccttgcgcg tagcgctata acatcaaaaa ctattcggag
     6121 ctctttacta ctgttccctg ttccctattc cctattccct actcccgtct tgatgcagtc
     6181 gctcatgggg gaaaccccca agaccgcgct gcatcgctac tccctactcc ctactccctg
     6241 ttccctgttc cctttgctat aaccttaaaa accgatataa tcatggaatt aaggacacta
     6301 caacagttat tttacgatgc tgtttttgaa aataatcctg ccagtacaca aacccttgct
     6361 caacacatca aagcagctaa acaattgact cctgctgaag ggttagccat ttatcgtagc
     6421 agtgtcctag gcaacctgag ccaaacctta atgtcaattt atccagtctg ctgttgtttg
     6481 gtgggagaga aattttttga gggaacagcg agaagctata tccaacgctt tccttctcta
     6541 tcaatggatt taggagatta tggtgagcac tttcctgatt ttctggccaa ttttgagcca
     6601 gccaaacagt taccctattt accagatgta gcgcggttag agtggcactg gcatcgggtg
     6661 tttaatggtg aagaagctac caagttagat gtccaagcat tgagtacagt tccccaagac
     6721 aaatggggag aactgatttt ccatttacct aaaaatagtg ttctgatcga gtcggcttac
     6781 ccgatccatc gcatttggga agttaatcag cctgaatacg aaggtgatca gcaagtcaat
     6841 ttggatgaag gggggataca actattcctc tggcgcaatg gttatgatat gcgcattgag
     6901 ctgccaacaa aagcagaatg gcaactgctg aaagcttttc aaggggacaa tcgatttgaa
     6961 gccatttgtc aagacctggc tgctgatgaa ttagctattg atgtagcatc tgaattaccg
     7021 caatttgtcc aacgtggatg gattgccagg ttttcgattt agacgtctcc ttataaagaa
     7081 ggatttcagc ttatttccgt agaacaggag tggggactta gtaaatagtt agcgttactt
     7141 tgcgtctgtt ttcggtagct tgcggatata ttcgccgcct gagacataga ccaaccattg
     7201 acgtctgcgt tcgagctttg tagctgaccg tgttcatgtt gtgaaagcct tacttttaac
     7261 cagtattcgc ccttgctcat tgaggggttt tgttggtata atactaggta ataacaggct
     7321 aacacgctat ggctcccaat cactcttaca cgacaaaact gaagcttaac aaccgtcaaa
     7381 aaacgttgat ggccaaacac gctggtttta gtcggtgggt gtacaactgg ggtttaggga
     7441 tgtggaaaga tgcctacaat gaagggttaa agcctaacat taaaacccta aagcggttat
     7501 ttaccaacca tgtcaaacct gagtatccct ggatgaggga attatcctca aaagtttacc
     7561 aatatgcgtt catcaattta ggggaagcat tcaaaaggtt tttcaaagga tggggtaagt
     7621 accctagatt caaatgcaag ggtaaaaatg atcgctttac tatcgataat tcagggagac
     7681 cgattcgatt aggtggacta attcataact tacccttcct gaagcaggtt agaacgtttg
     7741 aacccctacc agattgtcta actaaaaaag tcacaatcta caaaaaagcc ggggagtggt
     7801 atattagctt ctccatggaa aagacctttg aaccaacact taaagaacga gaaagagttg
     7861 gtgtggattt tggaataaaa accctagctg tattaagctc tggtgttgag tttgaaggac
     7921 ttaagcctta ccgcaacgct caacggaaat tatctagagt tcaacggaaa ttatctaaaa
     7981 aagaaagagg ctctcagaat tacttaaaaa cccagcttga agtacaaaaa ttccaccatc
     8041 gagtggctaa tctccgaaaa gactatcttc aggtgcgacc cgtggcgaat ttaattcgcc
     8101 aacggaaagc gcacctatat aaaatgacaa cttatatcgc taaaaaccac ggcgaagttg
     8161 tgattgaaga tttgaatgtt tcagggatga tggcgaatca caaattagct aaagcaatcg
     8221 gtgatttagg actgcatgaa gccagacggc aattgaccta taaatgtgaa cgctacggaa
     8281 caaagttagt agtggctgac aggttctttc catctagtca attatgttct aactgtggaa
     8341 atcaacagcc aatgccttta tcgcagaggg tttatagctg tgattgttgc gggaacaaaa
     8401 tcgaccggga ttggaatgcc tcagtgaacc tagaacgcta taacgagtac ggctcgactc
     8461 gtaagcctgt ggagggttaa ccgctcctat gcccccgttg aagcaggaaa taaacacaca
     8521 aagtatcgcg aagtgacgct ttgtacaggt tttatggagc agaggatcat tacttggtca
     8581 aacaatgcct atatcctgta ggactagtaa tggtgttttc accacgggac gacgaagagc
     8641 tggagacagt caagtccatc gttaagaaat cctacgaata tgctactggg gaagcgccaa
     8701 ggtagtattg taacaaaggt ctaaaagtaa gcggtcattg ttaaatcatc ttcaaaattg
     8761 tctctgataa gcctggggag ttaccatatt actgggttac gcaccttttg gtaagtaatt
     8821 gttttctaca aaaatgcata ttatgtttaa gctcactgaa aacaaaagac ggcaacttct
     8881 gttttcaatg aaaacacttc aggagagtca agaatcatga caaccactgg tggtaaatgt
     8941 ccggtgatac acggtagtgt aacaacaaat agtatgtcag agatggagtg gtggccgaag
     9001 gcacttcatc tcgatatttt gagtcagcat gatcgcaaaa ctgatccgat gggagtggac
     9061 tttaactatc gggaggcggt aaaaaaactt gatgtggctg cactaaaaca agacctacat
     9121 gcgctgatga ccgacagcca agattggtgg ccagcggatt ggggtcacta tggtggtctg
     9181 atgatccgta tgacctggca cgcagccgga acctaccgga ttgcggatgg tcgtggcggt
     9241 gcggggacag gtaatcaacg ttttgcgcca ctcaactcct ggccagacaa cgccaaccta
     9301 gacaaggcac gccgtctact ctggccgata aagaagaagt atggaagcca gcttagttgg
     9361 gccgatttga ttacctatgc tggcacgatc gcctacgaat ccatgggact aaaaaccttt
     9421 ggtttcgcct ttggtcgaga agatatctgg catcccgaaa aagatattta ctgggggcca
     9481 gaaaaggaat ggcttgcccc cagcgataac aaccacagcc gctattctga tgagcgaaag
     9541 ctagaaaatc cactggctgc ggtaacaatg gggttgattt atgttaatcc cgagggtgta
     9601 gatggcaatc ccgaccctat caaaaccgcc aatgacgtgc gcgttacctt tgcccgtatg
     9661 gcgatgaacg acgaagaaac cgtagctctt acagctgggg ggcatacggt gggcaaatgt
     9721 cacggtaacg gtgatcccgg gttgctgggc atggaacccg aaggggcaga tatccaagac
     9781 cagggcttgg ggtgggtgaa caatactggt cagggtattg gtcacaacac cgttaccagt
     9841 ggtatagaag gggcctggac gcctcagccg accctgtggg ataatggtta ttttcatatg
     9901 ctgctcaact atgactggga actaaagaag agtccagcag gtgcgtggca atgggaaccg
     9961 attgacccga aggaagaaga caagcccgtc aatgttgcag atccgacggt tcgcggcaac
    10021 cttgtaatga ccgacgccga tatggccatg aagatggacc caaagtatcg aaagatttcc
    10081 gagcggttct acaacgatcc tgaatatttc agtaatgtct tcagacgggc atggttcaaa
    10141 ctgacccacc gagatatggg gccaaagact cgctatattg gccccgatgt tccagaagag
    10201 gatctgatct ggcaagatcc tattccagcc gggaatactg attacgatat tcaagccgta
    10261 aaggaacgca ttgcagtaag cggtctgagc gttagtgaaa tggtttgtac cgcttgggac
    10321 agcgctcgta catttcgcgg atcggacaag cgcggtgggg caaatggggc gcgaattcgt
    10381 ctgactccgc agaaggattg ggaaggcaat gagccagctc gtttggcaaa agtattaact
    10441 gttctagaaa gcattgcagc agagaccaag gcaagcatag cggatgtgat cgtcttggcc
    10501 ggtaacgtag gtatcgagca agctgctcaa gccgctggct tcgaaattac tgtccccttt
    10561 tctccggggc ggggggatgc aacggatgag atgaccgacg cagagtcatt tgacgtgcta
    10621 gaacccattc atgatggcta ccgcaattgg ttgaagaaag actatgccgt cagtgcggaa
    10681 gagcttatgc ttgatcgcac gcagttgatg ggactgacgg ctcccgagat gactgtgtta
    10741 gtcggtggga tgcgtgtgtt agggaccaat tatgggggca caaagcatgg cgtattcacg
    10801 gatcgtgaag gtgctttgac taacgacttc tttgtgaacc tgacggatat gaactacctg
    10861 tggaaacctg taggtcagaa tctgtatgaa atctgcgatc gccagactaa tcaggttaag
    10921 tggacagcga cacgggtcg
//
