LOCUS       NZ_CP014859            21143 bp    DNA     circular CON 20-NOV-2024
DEFINITION  Actinoalloteichus hymeniacidonis strain HPA177 chromosome, complete
            genome.
ACCESSION   NZ_CP014859
VERSION     NZ_CP014859.1
KEYWORDS    RefSeq.
SOURCE      Actinoalloteichus hymeniacidonis
  ORGANISM  Actinoalloteichus hymeniacidonis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Actinoalloteichus.
REFERENCE   1  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J.,
            Zotchev,S.B. and Ruckert,C.
  TITLE     Complete genome sequence of the actinomycete Actinoalloteichus
            hymeniacidonis type strain HPA 177T isolated from a marine sponge
  JOURNAL   Stand Genomic Sci 11, 91 (2016)
   PUBMED   28031775
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J., Zotchev,S.
            and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2016) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Coverage                   :: 159x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001747425.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 01:17:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,434
            CDSs (total)                      :: 5,374
            Genes (coding)                    :: 5,337
            CDSs (with protein)               :: 5,337
            Genes (RNA)                       :: 60
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 3 of 37
            Pseudo Genes (incomplete)         :: 34 of 37
            Pseudo Genes (internal stop)      :: 1 of 37
            Pseudo Genes (multiple problems)  :: 1 of 37
            CRISPR Arrays                     :: 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:46:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5057579
            Orig. end                         :: 5078722
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014859.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21143
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="23"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21143
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21143
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11143](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11143
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    30..44
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     misc_feature    1328..1343
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.71"
                     /tool="antismash"
     misc_feature    complement(2591..2605)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            complement(3853..4635)
                     /locus_tag="TL08_RS21200"
                     /old_locus_tag="TL08_21520"
     CDS             complement(3853..4635)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="TL08_RS21200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21520"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_069851552.1"
                     /transl_table=11
                     /translation="MRRVTAIDYERFLDVMCIDGERLASCVDSAPGDSPVPGCPGLTLA
                     ETVQHLGDVYRSTADQTRLPNNREVTPSSGIRSSIPGDSARLAAYLRAGLAEVSGELSA
                     HRPEERCATWWPADASFGFWARRLTHETIVHRVDVQAAAGLRRDHVDTDIAVDGVDEVL
                     TLWFDHQLGELAITASRAATVAVRTGGRAWVAYAGPTGTRVRAVDPNAVGPVDATVSGD
                     PFSVYLWLWGRLPDWTVRFEGDADAIAQFWVLLSVATR"
     gene            complement(4632..5102)
                     /locus_tag="TL08_RS21205"
                     /old_locus_tag="TL08_21525"
     CDS             complement(4632..5102)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037499.5"
                     /locus_tag="TL08_RS21205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21525"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_236750360.1"
                     /transl_table=11
                     /translation="MFVRFDSVVTRPEPADQALALGTVPAARRVPVPPPSALDLLRQAR
                     LALAEARVAADHHDRFLAAYLSALRSGAAVLATRARPEPGLGRPRSVWGLLAGVAPGLA
                     EWAGFFESYAARRAAVQDGERDIVSVRDADDLERQVHEFTLLAEAAVYGRRR"
     misc_feature    5151..5166
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 24.56"
                     /tool="antismash"
     misc_feature    complement(5152..5165)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.87"
                     /tool="antismash"
     gene            5233..5730
                     /locus_tag="TL08_RS21210"
                     /old_locus_tag="TL08_21530"
     CDS             5233..5730
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155372.1"
                     /locus_tag="TL08_RS21210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21530"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_069851554.1"
                     /transl_table=11
                     /translation="MEHPGIQRVAAALIAAGLDESAQRIRILESDVKTAAQAADAVGVD
                     VGAIANSLIFDAGPAPLLALTSGAHRADTTLLASAIGAQQVGRAKPDYVRLHTGQVIGG
                     VSPVGHPVPITTLIDAALQQYPVIWAAAGHPKAVYPSTFEELVRLTGGRVLDVAATGSP
                     TS"
     gene            5784..6296
                     /locus_tag="TL08_RS21215"
                     /old_locus_tag="TL08_21535"
     CDS             5784..6296
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419641.1"
                     /locus_tag="TL08_RS21215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21535"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_069853989.1"
                     /transl_table=11
                     /translation="MQSRLGEALHVYVTAMRYPPSAMHHRGPTWLGHAAREGWRGVAAV
                     DRRGDMVGVAYGYRGAPGQWWYEQVHHGLLDTGDADGARYWLRDYFELTELHVLPGTQG
                     RGIGEALLRMLLDEAIGAQVLLSTPEGPSRAWQLYRRVGFEDVLRNYRFAGDPRPFAVL
                     GRPLPLD"
     gene            complement(6384..8090)
                     /locus_tag="TL08_RS21220"
                     /old_locus_tag="TL08_21540"
     CDS             complement(6384..8090)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800246.1"
                     /locus_tag="TL08_RS21220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21540"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_069851556.1"
                     /transl_table=11
                     /translation="MSSSSSQPDHGVHAISDRYVDDSVALAPNEATFMGIDGYDDKLTD
                     FSPEGFRDRGRLVSDALRAMADVEPADDAERVAKAVFQERVGLSDELHQAGLDSSALNI
                     IASPVQEIRELFDLMPTDTTEHWENIAARLKGVPTALAGLRVSLGESADAGRCSALRQI
                     RRVAEQCDTWSGQGDVTSFFVSLTDGAQQRTDVGAALRTELAAGAKAASEAYADFGRFL
                     RDDLAPKAPRKDAVGRETYQLFSRYFLGARLDLTEAYEWGWEEFFRIEKEMHELAGRLL
                     RPGASLAETAQALDRDPRYRVDGQDAFQRWMQDLSDTALRELRGTHFEIADELMRLECR
                     IAPPGGGNGAYYTGPSEDMTRPGRMWWSVNTDKSDFSTWREVTTVYHEGAPGHHLQIAT
                     AVNQQDRLNKFQRLMCFVSGHGEGWALYSERLMRELGYLSDDGDLMGMLSAQLLRAARV
                     IVDIGMHLELEIPAGTGFHEGERWTPELGLEFMLDRTIEDRDLIPDEVDRYLGWPGQAP
                     SYKLGERLWLAARDDARRRGGADFDLKTFHRQALDLGCLGLDDLRAQLALL"
     gene            8233..8916
                     /locus_tag="TL08_RS21225"
                     /old_locus_tag="TL08_21545"
     CDS             8233..8916
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF047061.1"
                     /locus_tag="TL08_RS21225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21545"
                     /product="DUF3153 domain-containing protein"
                     /protein_id="WP_069851558.1"
                     /transl_table=11
                     /translation="MATQLEVPRSRRRVPALALVLSFVALSLCGCLRLDLTMDINDQDR
                     VSGRFVIAATPSRPDDMGPVVQVPPGMDQLVAVEPYDEDGYVGTLLTFQNLTFEQLQEL
                     TSTGPDPTRYRVSLRQIGENLSFNTTMDLSKVREENADIKIAITFPAEVHNTNGRVEGK
                     TVTWRPRVGELNTLRASLQHGGAGDTWLLGSLIVGGLTGGASVAVGALALRSHRFSRRL
                     VQRDS"
     gene            complement(8992..9876)
                     /gene="metF"
                     /locus_tag="TL08_RS21230"
                     /old_locus_tag="TL08_21550"
     CDS             complement(8992..9876)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332694.1"
                     /locus_tag="TL08_RS21230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21550"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_069853990.1"
                     /transl_table=11
                     /translation="MTRVVDRLRAQRPVFSVEFFPPRDDESERQLWRTIRELEPLDPAF
                     VSITYGAGGSSRDRTIRTTGRIAQETTLVPMAHLTGVDHSLAELRNVIGWYAAVGVHNV
                     LAVRGDPPGDPMGEWLPHPEGITYAEELVRLVRELGPFCIGVAAFPYGHPRSADLEVDA
                     DHLVRKIEAGADFAIAQLFFEPDDFLRLRDRLAARGCDVPLLPGVMPLTTMRTLRKTVE
                     LSGADVPPFLAKRLERFADDPRGFRAEGIEVVTELCSKLLAEGVDALHFYTLNRSPATR
                     EVVGRLGLLPARS"
     misc_feature    complement(9904..9919)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.91"
                     /tool="antismash"
     gene            10001..11143
                     /locus_tag="TL08_RS21235"
                     /old_locus_tag="TL08_21555"
     CDS             10001..11143
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010231352.1"
                     /locus_tag="TL08_RS21235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21555"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_311734452.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.8e-42, bitscore:
                     143.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATSTHRISAPAAAVPTGSTGRGHDDLRSRVDRALATFLHQRRAT
                     IGATVPEFAEAMDSLIDLVLGGGKRLRPTFAWWGWRAAGGDPSSPESEAVVRAVSALEL
                     IQGCALVHDDLMDDSPRRRGAPTIHVAFAERHRRAGWATAPDRFGMAAAVLLGDISLAW
                     ADDMLRESGLDIEAAARAVQPWQAMRTEMLAGQYLDMLSQVRCDEDPETALRVDRFKSA
                     AYTVERPLHLGAAIAGGSSEIVTGLRHFGTDLGVAFQLRDDQLGVFGDPAVTGKPAGDD
                     LREGKRTLLLSVGLRRARERADDASTKLLRAAIGNPDLDEDGVSSVRTVLLRLGAVAEI
                     EREIERLTARALSVLEATGIDAVAKERLVELSAVATRRNH"
     misc_feature    10739..10741
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11185..11198)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.73"
                     /tool="antismash"
     gene            11287..12903
                     /gene="mptB"
                     /locus_tag="TL08_RS21240"
                     /old_locus_tag="TL08_21560"
     CDS             11287..12903
                     /codon_start=1
                     /gene="mptB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016696877.1"
                     /locus_tag="TL08_RS21240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21560"
                     /product="polyprenol phosphomannose-dependent alpha 1,6
                     mannosyltransferase MptB"
                     /protein_id="WP_069853992.1"
                     /transl_table=11
                     /translation="MRSPDVPSTTAATISAAGRSTLHRPNRTSRENALSNSPDQRRLIH
                     RLAVFRRLVPLRIVLLGAAGSVLIALGAVGAAGVLNHDPLLADSGLSWVRFGHGRDLAS
                     GLLYLGLGLLVWAWVRLGREVRIERVGTHGVLATIAGWLLPLLFTPPLFSRDAYSYLAQ
                     GNLAAHGIDPYQMGPAALPGPLADNVSWVWQNTPAPYGPLFILVSMLVVMVTGQHLILG
                     VLLMRLVMVLGLVLLCWALPKLARLLGGRPERALWLAAANPLMLVHLVGGPHNDLLMVG
                     LLAAGVLVCLQGRHVWGVALITMAAAMKATAVIALPFMVWVWAARLHGSPQSRFIRAAS
                     ASLVVSLGVFATCTLVTGVDLGWIGALETSSLIVNWLSVPTAVAQIAELIGGWFIDLSL
                     PSLLALTRMLGMVAFFFVAVWQWWKARHGGLEAAVYRATITLFALALLSPATLPWYFSW
                     PLALGAVLNWPGAATAAAVCGSVWLLLVTFPSGDTALYSWFYLLGALAVSVLAAVSLVR
                     PDPLRLSSRSKVADTASLPPG"
     gene            complement(13056..13424)
                     /locus_tag="TL08_RS21245"
                     /old_locus_tag="TL08_21565"
     CDS             complement(13056..13424)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657740.1"
                     /locus_tag="TL08_RS21245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21565"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_069851559.1"
                     /transl_table=11
                     /translation="MSEFPTAPDVLDPEVEVLPLPDVAERLGVPFTRVHQMLRDGLLLA
                     VRRDGVALVPAEFLTDEENIVKGLPGTVTVLRDGGFSHGEIMRWLFTEDDTLPGRPITA
                     LRENRGREVRRRAQAMAF"
     gene            13529..15646
                     /locus_tag="TL08_RS21250"
                     /old_locus_tag="TL08_21570"
     CDS             13529..15646
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005445905.1"
                     /locus_tag="TL08_RS21250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21570"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_084643332.1"
                     /sec_met_domain="Pkinase (E-value: 1.2e-45, bitscore:
                     154.2, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRREAHVIGTTLEGRYRIDSVLARGGMSVVYRGVDLRLDRPIAV
                     KVMDQRFSGDADFVRRFELEARSAARIHHSSVVAVHDQGVDHTSGGEQVFLVMELVDGG
                     TLRDLLRSQGTLSPAVALSVLEPVLSALDSAHRAGMVHRDVKPENILISRDGVVKVADF
                     GLVRALADAKTTSDSVILGTVDYLAPEQVTTGETDARGDVYAAGVVLYELLTGAPPFTG
                     DTPFSTAYRHVNDRVPAPSERVAEVPAAMDALVLAATRREQEERPADAAALLARLRETR
                     ATLGLSSVAVPGVVPPAGPTSAAPGSAAGADDGTIVTQAVGGLPPESPNPASGIDGPTV
                     RTPLPAGGPAPARPPGHRATQALSRNELPGGPNDAAAGNAAHAAHLGGLGDRGDRGNRG
                     RRGRRGKPGGKAGGLFSKASTRLIAMGVVLVLALLLWWWNSAQWTSVPALAGMEVEEAE
                     DSLTAAELDARLVHVPHNDIAAGVVIDSAPDQGRRIRRGDDVRVRVSSGLPTVPEITPG
                     ISPDEATTQIEDAELEVAIDEELAEHSAEVEEGAVIRTEPGAGTELEIDSTVTLILSLG
                     PPPVPVPDVAGSSRDEAFAAIREAGFEPYELEAEFSESVDGGDVIRTDPPAETLIETPG
                     TRIGVVLSNTIIAPYVTGDRLRDVRQTIEDLGLELEVQQFFGGDNARIVGQFPPSGTRL
                     RPGDVFTVNTF"
     gene            15732..15938
                     /locus_tag="TL08_RS21255"
                     /old_locus_tag="TL08_21575"
     CDS             15732..15938
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016699427.1"
                     /locus_tag="TL08_RS21255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21575"
                     /product="hypothetical protein"
                     /protein_id="WP_069851560.1"
                     /transl_table=11
                     /translation="MIGDRGRVTGKIGPGLVGEVMISIRGGVEAFYAYPAEAGEVIEPG
                     EQVLVVDHQPPRSVYVQRWLPLG"
     gene            16004..17497
                     /locus_tag="TL08_RS21260"
                     /old_locus_tag="TL08_21580"
     CDS             16004..17497
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657737.1"
                     /locus_tag="TL08_RS21260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21580"
                     /product="flotillin family protein"
                     /protein_id="WP_069851561.1"
                     /transl_table=11
                     /translation="MPDGPLLIAILVAAGILVFVILLRVLWKVAEPNEALIISGFGTGS
                     TPKSRPDSMGFKIITGKGSLVLPGFQVARRLSLDTNGANLQVSCVTQQGLPVTVRAVVI
                     YKVGDDFVSIANAARRFLDRQDGMNSTIHELFSGHLRSICGGLTIEDLIHNRDALTGAV
                     RQSSADEMSKLGLVIDSLQIQEIDDESGYILNLGKPHAAAVAASARIAEAQRDQEATEA
                     EQQAAAKKAASVRESEIQQAGYQAEMDEARARSSQSGPLAEASARQEVVVQETKAAELE
                     ANLSEQRLLSEISKPADAKAYETRTIAEAERDARIARAQAEARETELRAAADATRVKTA
                     AEAEASATKQRGVAQADATRATGEAEAAAAKAKGLAEADAAKAKGLAEAEGIRARSAAL
                     AENQEAVVAQQLAEHWPEIVDAGAKAFSSIDNLVVLNGADGMSDLFGKALSLGGTGLGL
                     AKTLMESVQGDTPADKSETKGSTASVQSIPVDRDEHSKN"
     gene            complement(17632..17832)
                     /locus_tag="TL08_RS21265"
                     /old_locus_tag="TL08_21585"
     CDS             complement(17632..17832)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005462095.1"
                     /locus_tag="TL08_RS21265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21585"
                     /product="hypothetical protein"
                     /protein_id="WP_221313750.1"
                     /transl_table=11
                     /translation="MVQRGSDKHGARLDDELSHEVEGMTRANRSVRAEEALTPEPPADD
                     DPLVANRAHPEEPDEHPPPGE"
     gene            complement(17870..18985)
                     /locus_tag="TL08_RS21270"
                     /old_locus_tag="TL08_21590"
     CDS             complement(17870..18985)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037526.5"
                     /locus_tag="TL08_RS21270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21590"
                     /product="Vms1/Ankzf1 family peptidyl-tRNA hydrolase"
                     /protein_id="WP_157421227.1"
                     /transl_table=11
                     /translation="MELGLLRELATRSGPCAVAYFDVTRDTEEAFRANALRRRAVGEEL
                     ADRGVDAETLAAMDEAIGSEPWVVGRAGRAVVGRDGTVLLDRVLPEPPANTVTAYSRVP
                     DVFPLLVAVSSDEPVVVAVVDRVGADIGVHVRDGGWREHTVRGDERPVHKVRGLGWSQN
                     RVQRRVENTAAHNAAEIAHEVDRAAAEIGSRLIVIAGEVRARAEVMAALPSRSRTIAVE
                     AEHGGRAAGSDRTALAEEVQRIAAEFLADETEQVLDRFQSELGAGQGLAVSGPEPVVAA
                     LRAGAVETVLLPSDGMHRDVTVGEEATDISFGAQDANSMAGEMTADVAVGRAESAVALA
                     AAATDASLFVIDPVDAVPDGVGAMLRFPMPR"
     gene            19225..19689
                     /locus_tag="TL08_RS21275"
                     /old_locus_tag="TL08_21595"
     CDS             19225..19689
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TL08_RS21275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TL08_21595"
                     /product="hypothetical protein"
                     /protein_id="WP_069851563.1"
                     /transl_table=11
                     /translation="MSDRSEFELPQPGATDNELLSVFEELDEDELDVDPLEGGVDPPEN
                     WQRTTSSGVTPREMLEGETLDARVAAEVPDTPPEEEGTARPAVERELEDLDSSVDEVVD
                     HGDAGPEEGMELEPTEVGPTGEPIEDFPAWSGDPSGAAEDMSVHPTTELD"
     gene            complement(19751..20620)
                     /locus_tag="TL08_RS21280"
                     /old_locus_tag="TL08_21600"
     CDS             complement(19751..20620)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016701388.1"
                     /locus_tag="TL08_RS21280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_21600"
                     /product="glycerophosphodiester phosphodiesterase family
                     protein"
                     /protein_id="WP_069851565.1"
                     /transl_table=11
                     /translation="MRLSARSVRPVLLLSLLMVGVTTPIAGAAETNHRGGPEVIAHRGS
                     SGVAPENTVAAITTAREHRADSVEVDVQRTADGELVLFHDCTLERTTNVEEVFPDRESR
                     VLSDYTADELAQLDAGSWLSPEFAGEPIPTLREGIRALGVRTDLLLEVKVCEGEEGLGE
                     AVADGLREIPGYLPRALALDSLVVQSFDHEQTREFHDELPRVPVGLLFGARPTDAELAD
                     AATWAQQANPRYTLVDQELVDQVHSLGLDINVWTVNEEADMTAAVDLGVDGVITDYPQV
                     LRELLRTS"
     misc_feature    21126..21141
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.65"
                     /tool="antismash"
     misc_feature    21128..21142
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.36"
                     /tool="antismash"
ORIGIN
        1 ccgcctgccg atccgcgccg gttcccggcg gaggcggtcg gccagtccgg tgtgacgacc
       61 ggggcgcccg ccgtcgtcgc caaggcccac cacggctcga tggcccggct ccagcgcacc
      121 gaggtcgagg aggagctcaa ggcggggctg ctgccgtgtg tcgtggcgac ctcctcgttg
      181 gagttgggca tcgacatggg cgcggtcgac ctggtgatcc aggtggaggc accgccgagc
      241 gtggctgcgg gactgcaacg ggtcgggcgg gccggtcacc acgtcgacgc ggtgtcgacc
      301 ggggtgatgt tgccgaaatt ccgcagcgac ctggtctcct gcgcggtcgt cgcggagcgg
      361 atgcgcggtg gggccatcga ggagatccgg tttccccgca atccgctgga cgtcttggcc
      421 cagcacatcg tggcgatggt ggcgatggat cagtggtcgg tggatgagct cgccgcgctg
      481 gtgcggcggg cggcgccgtt cgccgagctg ccggggtccg cgctggactc ggtcctggac
      541 atgctcgcgg gccggtatcc cagcgaggag ttcggcgagc tgcgggccag gatcgtctgg
      601 gatcgcggcg cggatgtgct gcacgcgcgg cccggcgcgc aacggctggc cgtgacctcc
      661 ggcggcacca tccccgatcg ggggctgttc ctcgtcacga cgcccggcgg cgagggcgag
      721 accggctcgc gggtcggcga gctggacgag gagatggtct acgagtcccg ggtgggcgac
      781 accttcctac tcggcaccag ctcgtggcgg gtgcaggaga tcacccacga ccgggtcatc
      841 gtggtgcccg cccccggaca accggcgcgg atgccgttct ggaagggcga ttcgccggga
      901 cggccgctgg aattggggat cgccctcggc aggttcgtcc gggaggtcgt cgccgccgaa
      961 cccgccgagg cccgcaggcg cgccgaggag gcgggactgg acgactgggc gtgcgggaac
     1021 ctgctggcct atctcgccga ccagcgggcg gccaccggcc gcgtctccga cgatcgcacc
     1081 gtggtcctcg aacgctttcg cgacgagctc ggcgactggc agtgggtggt gcactccccc
     1141 ttcggcgatc gcgtcaacgc gccgtgggca ttgctcatcg cggcccggct gcgcgatcga
     1201 ctcgggatcg atccgcagat cgtgcacgcc gacgacggca tcgtgcttcg gctacccgcc
     1261 gaggtcgccg aggaacacgg cgagcacacc gtcggcgccg aggacatcct cttcgacccc
     1321 gaccaggtgg agcggctggt cagcgccgag gtgggcacct ccgcgctgtt cgccgcccgc
     1381 ttccgcgagt gcgccgcgcg gtcgttgctg ctgccccggt gggatccccg acggcggagt
     1441 ccgctgtggc ggcaacggca acgctccgcg cagttgttga cggtggcggc ccagtacgag
     1501 cggttcccgg tgatgctgga gacgatgcgg gagtgcctgc gcgacgtcta cgacctgcca
     1561 gggctcgtcg cggtgcagcg cgacgcctcg acccgtcgta tccaggtcat cgaggtgcag
     1621 acgcctgcgc catcgccgtt cgcccgcgcg ctgctggtcg gatacgtggc gatgttcctc
     1681 tacggcgggg acaccccgtt ggccgagcgg cgggcggccg gactgacgtt ggatcccacg
     1741 ttgctcggcg agttgctggg ttccgacgcc gtgcgcgatc tcctcgatcc cacggtgttg
     1801 gcggagatcg aggcggccct gcaacggacc gatccggagc atcgggtgtc cgatgtcgag
     1861 ggcgtggccg acctgctgcg attcctcggc gatctggatc gcgaggagct catcgccagg
     1921 ggcgggctac cggagtgggc cgaggaactc gtcacggccg ggcgcgcggt ggtgttgtcg
     1981 atggcgggga ccgaccgctg ggttgcggtg gaggacgccg cccgctatcg agacgcactc
     2041 ggcgtccggc tgcccgccgg actgcctcgg gcgttgctcg caccgacctc cgatgccctc
     2101 ggcgagctgc tgatccgcta tgcccgaggt cgcgggccgt tccgtgcggc gcaggccgcc
     2161 gcgcggttcg gcgtgggcgt cgggccggtg accgaccggc tggatcggct cgccgccgca
     2221 ggccggttgt cgcggggcga gctgcgaccg gtcgagtccg aatcggcgaa cgcacccgcg
     2281 accctcgacg gctccgcctc ggacgcgacc gagcgtgggg cggcccccac cgaatactgc
     2341 gacgtcgagg tgctgcgcag gctgcggcgc ggctcgctcg cgcggctgcg ggccgaggtc
     2401 gagccggtgg agcccgccgc gctcggccgg ttcctccccg attggcatgg cgtgccggtc
     2461 ctcgatgtcg ccgatcagga acggcagacg gttccggcgg cgcctgctcg acagccggtc
     2521 gtggcgaccg ccgacgacgt cttggccgtg atcgagcagc tggcgggcgc accgctgccc
     2581 gcgagcgcgc tggaatcgat gatcatgggc acccggttgc ccggttatct accggccgcc
     2641 ctcgacgagc tgacctcggc cggggaggtc atctggtgcg gtgcgggcgc gctgggcggc
     2701 aacgacggtt ggctggcatt ggcgcccgcc gatctcgccg agctggtgct cccgcctccc
     2761 gtcgaggacc cgggtctcga caccgaactg catcgggcgg tgctcgcggc gttggaaccg
     2821 ggcgggctgt tcttccgcac cctggtagac cggctcggca cgtggacggc ggagcgcggc
     2881 gagccacgtc acgcggaggg cgaggtcgtc acggcgctgt gggaactcgt ctgggcgggg
     2941 ttggtcacca acgacacgct ggccggactg cgcgcgctga tctccggtgg cggcgccacc
     3001 caccgagccc gaccggtatc gccccgaggt cgccgttccg ggctgcgggc cacccgacat
     3061 ggcaggccgc tgtccggcac cggcgggccg cccacggtcg cgggtcgctg gtcgttggcg
     3121 cccgtccggg tgaccgatcc gacccggcgg gcacatgccc aggccgaggc gctgctggct
     3181 cggcacggcg tgctcaccag gggctccgtg gagggcgaac gggtgccggg tggtttcgcc
     3241 ggggtgtatc gggtgctgcg ggcgatggag gaatccggtc ggtgcaggcg tggtctgctg
     3301 gtccggggcc cgagcggtgc ccagttcgca atgcccggcg cggtggacgg gctgcgcgag
     3361 tggtccaggg aagcaggccg gtacaggagt gcgccggggg cactggtgct ggcggcggcc
     3421 gacccggcgc agccgtatgg cgccgccctg ggctggccga ccccgatcgg cgccggtgcc
     3481 caccgcccgg gtcggaaggc gggcgcgctg gtcgtctcgg tcgatggcga ggcggtgctg
     3541 tacgtggagc gcggcggacg atccctgttg tcgttcaccg aagagcagcg ggagttgcgg
     3601 ctggcggcgt cggcgttggt ggcggtcgtc cgctcgggcc gcgtcgagcc cttggtgctc
     3661 accaggaccg atggggagca ggcgttgggc tcgcggctgg ccgccgtgct gaccgaggcg
     3721 ggtttccgca gcaccccgaa ggggctgcgg ctacgcggct gacctcaccg gtcttcgatc
     3781 ggcccggaga ctcgtcggca atccggtgtg gccgttcggg gcgacgcggc gctgcgtcgc
     3841 cccgaacggt cgtcacctgg tggccacgct gagcagcacc cagaactggg cgatggcgtc
     3901 ggcgtcgccc tcgaagcgga cggtccagtc cggcagcctg ccccacaacc acaggtagac
     3961 cgagaatgga tcgccggaga ccgtcgcgtc gaccggcccg accgcattcg gatcgaccgc
     4021 ccgcactcgg gtgccggtcg ggccggcata ggccacccag gcccggccgc cggtccgcac
     4081 ggccaccgtc gccgcgcggg acgcggtgat cgccaactcg ccgagctggt ggtcgaacca
     4141 cagggtcagt acctcgtcga cgccgtccac cgcgatgtcg gtgtcgacgt ggtcccgccg
     4201 gagtccggcc gcggcctgca cgtcgacccg gtgcacgatc gtctcgtggg tcaaccggcg
     4261 ggcccagaaa ccgaagctgg catcggcggg ccaccaggtg gcgcaccgtt cctccggccg
     4321 gtgggcggac agctccccgg agacctcggc gagtccggcg cgcaggtagg cggccaatcg
     4381 ggccgaatcg ccgggaatcg acgacctgat tccactcgat ggggtgactt ctcggttgtt
     4441 cgggaggcgg gtctgatcgg cggtggaccg atagacgtcg ccgagatgct gcaccgtctc
     4501 ggcgagggtc aggccggggc agccgggaac cgggctgtcg ccgggggcac tgtccacgca
     4561 ggacgccagt cgttctccgt cgatgcacat gacgtcgagg aaccgttcgt agtcgatggc
     4621 cgtcactcgc ctcatcgccg cctcccgtat accgccgcct cggccagcag ggtgaactcg
     4681 tggacctgac gttcgaggtc atcggcgtcg cgaaccgaca cgatgtcgcg ctcgccgtcc
     4741 tgcacggcgg cccggcgagc ggcgtaggac tcgaagaacc ccgcccactc ggccaatccg
     4801 ggtgcgaccc cggccagcag gccccacacg ctgcgcggcc tgccgagccc cggctccggg
     4861 cgggccctgg tggcgagcac ggccgcgccg gaccgcagcg cgctcaggta ggccgcgagg
     4921 aagcggtcgt gatggtcggc ggcgactctc gcctcggcca gagcgaggcg ggcctgccga
     4981 aggaggtcga gcgccgaggg gggaggtacg gggacacgcc gcgcggcagg aaccgtcccg
     5041 agcgcaagag cctgatcggc gggctcggga cgggtcacga cggagtcgaa tcggacgaac
     5101 acggcggcct ccggagatag cttgctcgcg aggacgagtc agaacagaat tcgaactgat
     5161 gttcgaatgc ctccacagta acccgaggtg ccggcggcgc gccagacgtg atctgatgaa
     5221 tgggtgagcc cgatggagca ccctggtata cagcgggtcg cggcggcgtt gatcgcggca
     5281 ggtctcgacg aatcggcaca gcgcatccgg atcctggaat ccgatgtcaa aacggcggcc
     5341 caggcggccg acgcggtagg cgtcgacgtc ggcgccatcg ccaacagcct gatcttcgac
     5401 gccggtccgg ctccgttgtt ggcgctcacc tccggcgcgc atcgcgccga caccacgctg
     5461 ctggcctccg cgatcggagc gcagcaggtc ggccgcgcca agcccgacta cgtccgactg
     5521 cacaccggcc aggtgatcgg cggtgtctcc ccggtcggcc atcccgtgcc gatcaccacg
     5581 ctgatcgacg ccgccctcca gcagtacccg gtgatctggg cggccgcagg tcaccccaag
     5641 gccgtgtacc cctccacctt cgaggagctg gtccggctga ccggcggccg cgtgctcgac
     5701 gtcgcggcga ccgggagtcc cacctcgtga gcgcagcggc aaccgcggac tgggaacgtc
     5761 tcatcgaatt gtcacccgaa gagatgcaat cccgactcgg tgaggcgctg cacgtctacg
     5821 tcaccgcgat gcggtacccg cccagcgcca tgcaccatcg cgggccgacc tggctgggac
     5881 acgccgcccg agagggctgg cgcggcgtcg ccgccgtcga tcgccggggc gacatggtcg
     5941 gcgtggccta cggctatcgg ggcgcccccg gccaatggtg gtacgaacag gtgcaccacg
     6001 gactgctcga caccggcgac gccgatggag cgcggtactg gcttcgcgac tacttcgaac
     6061 tcaccgaact ccacgtcctg ccgggcactc agggccgggg catcggcgag gccctgctgc
     6121 ggatgctgct ggacgaggcc atcggcgctc aggtgctgtt gtccaccccg gagggtccga
     6181 gccgggcgtg gcagttgtac cgccgagtcg ggttcgagga cgtcctgcgc aactaccgct
     6241 tcgcgggcga cccacgcccg ttcgcggtgc tcggcaggcc gctcccgctg gactagcggc
     6301 ccggccgcga cgcaggccca cccgggtgtt caaacccgcg cgggcctgcc cctcggccgg
     6361 atcgaggacc tcggagagcc gactcagagc agggcgagct gggcccgaag gtcgtccaat
     6421 ccgaggcaac ccaggtcgag ggcctgccgg tggaaggtct tgaggtcgaa atcggcgccg
     6481 ccgcgacgac gggcgtcatc ccgggccgca agccacaacc gctcgccgag cttgtaggac
     6541 ggggcctgac cgggccagcc gaggtagcgg tccacctcgt cggggatcag gtcgcggtcc
     6601 tcgatggtgc ggtcgagcat gaactccaga cccagctcgg gcgtccagcg ctcgccctcg
     6661 tggaagccgg tgcccgccgg gatctccagt tcgaggtgca tgccgatgtc gacgatcacc
     6721 cgagccgccc gcagcagttg cgcgctgagc atccccatca ggtcgccgtc gtcggagagg
     6781 tagcccagct cgcgcatgag ccgctccgag tacagcgccc agccctcgcc gtggccggac
     6841 acgaagcaca tcaggcgctg gaacttgttg agtcgatcct gctggttgac cgcggtggcg
     6901 atctgcaggt gatgaccggg cgccccctcg tggtacacgg tggtgacctc gcgccaggtc
     6961 gagaaatcac tcttgtcggt gttgaccgac caccacatcc gacccggccg ggtcatgtcc
     7021 tcgctcggac cggtgtagta ggccccgttg ccgccgccgg gcggcgcgat acggcactcg
     7081 agccgcatca gctcgtcggc gatctcgaag tgggtgccgc gcagttcgcg cagcgcggtg
     7141 tccgagaggt cctgcatcca gcgctggaag gcgtcctgcc cgtccacccg gtagcgcggg
     7201 tcgcggtcca gcgcctgggc ggtctcggcg agcgaggcac ccggccggag cagtcgcccc
     7261 gccagctcgt gcatctcctt ctcgatacgg aagaactcct cccagcccca ctcgtaggcc
     7321 tcggtgaggt ccaaccgggc gccgaggaag tatcgggaga agagctggta ggtctcgcgg
     7381 ccgacggcgt ccttgcgggg tgccttcggt gcgaggtcgt cgcggaggaa ccggccgaag
     7441 tccgcgtagg cctccgaggc cgccttcgcc ccggccgcca gttcggtgcg cagggccgcg
     7501 ccgacgtcgg tccgctgctg cgcgccgtcg gtcagggaga cgaagaacga ggtgacatcg
     7561 ccctgtcccg accaggtgtc gcactgctcg gcgacccgcc ggatctgccg caacgcggaa
     7621 cagcggcccg catccgcgga ctcgcccagc gagacccgca gccccgccag cgccgtggga
     7681 acgcccttca accgggcggc gatgttctcc cagtgctccg tggtgtcggt cggcatcagg
     7741 tcgaaaagct ccctgatctc ctgcacgggg ctggcgatga tgttcagcgc cgacgagtcc
     7801 agacccgcct ggtgcagttc gtcgctgaga ccgacccgct cctggaagac cgccttggcg
     7861 acccgctcgg cgtcgtcggc aggctccacg tcggccatcg cacgcagcgc gtcggacacg
     7921 agccgacccc ggtcgcggaa gccctccggg gagaagtcgg tcagtttgtc gtcgtagccg
     7981 tcgataccca tgaaggtcgc ctcgttcggc gccagggcca ccgagtcgtc cacgtatcga
     8041 tcactgatgg cgtgaacgcc gtggtcgggt tgggaggaag aagaggacat gacggcacgc
     8101 tacctgtcga gaagcccgcc tctccccggg ttttttccgt tcgcgctcgg gcggcaccgc
     8161 ccgctttcta gtcctgcccg cctgcccgcg catctcgggc ggaatcgccg atgctgctgc
     8221 cacgatggcc gggtggccac gcagctggag gtaccccgca gccgccggag agttccggcg
     8281 ctcgcgttgg tcctgtcgtt cgtcgccctg tccctctgcg ggtgcctgcg actggacctg
     8341 accatggaca tcaacgacca ggaccgggtc tccgggcggt tcgtcatcgc cgccacgccc
     8401 agtcgccccg acgacatggg accggtggtc caggtgccgc cggggatgga ccaactcgtc
     8461 gcggtcgagc cgtatgacga ggacggctat gtcggcaccc tgctgacctt ccagaacctg
     8521 accttcgagc agcttcagga gctgaccagc accggcccgg acccgacccg ctatcgcgtc
     8581 agcctgcgtc agatcggcga gaacctgtcg ttcaacacca cgatggatct cagcaaggtc
     8641 cgcgaggaga acgccgacat caagatcgcc atcaccttcc cggccgaggt gcacaacacc
     8701 aacggccggg tggagggcaa gaccgtcacc tggcggccga gggtcggcga gctgaacacc
     8761 ctgcgggcgt cgttgcagca tggtggggcg ggcgacacct ggctgctggg ctcgctcatc
     8821 gtcggcgggc tgacgggcgg cgcgtccgtc gcggtcggcg ccctcgcact gcgctcgcac
     8881 cgcttcagcc gcaggctcgt gcagcgcgac tcctgactcg acgtcggttg ccctcgacat
     8941 cggttgccct cggcgcaggc agccgctccc ggcccgcgcc gagggtacgt gtcacgacct
     9001 cgcgggcagc agccccagtc ggccgacgac ctccctggtg gcgggcgagc ggttcagtgt
     9061 gtagaagtgc agcgcgtcga cgccctcggc caacagcttc gagcacagct cggtgaccac
     9121 ctcgatgccc tcggcccgga aacccctcgg gtcgtcggcg aatcgctcca aacgcttggc
     9181 gaggaacggc ggcacgtccg cgccggagag ctcgacggtc ttgcgcaggg tgcgcatcgt
     9241 ggtcaacggc atcaccccgg gcagcagcgg aacgtcacaa cccctggctg ccagccgatc
     9301 ccgcagccga aggaaatcgt cgggttcgaa gaagagctgg gcgatggcga aatcggcgcc
     9361 tgcctcgatc ttgcgcacca gatgatccgc gtcgacctcc agatccgccg aacgcggatg
     9421 cccataggga aacgcggcga cgccgatgca gaacgggccg agttcccgaa ccaaccgcac
     9481 cagttcctcg gcgtaggtga tgccctcggg gtgcggcaac cactcgccca tcgggtcgcc
     9541 gggcgggtct ccccgaaccg ccagcacgtt gtgcactccg acggcggcgt accagccgat
     9601 gacgttgcgt agctcggcca gcgagtgatc gaccccggtc aggtgagcca tcggcaccag
     9661 ggtggtctcc tgggcgatcc gtccggtggt cctgatggtc cgatcccggc tcgatccgcc
     9721 cgccccatag gtgatggaga cgaacgccgg atcgagcggc tccagctcgc gaatcgtccg
     9781 ccacagctgc cgttcgctct cgtcgtcgcg gggtgggaag aactccacgg agaacaccgg
     9841 gcgctgtgcc ctcaatcgat ccacgacgcg agtcatgaat tccaccctaa gggggtccac
     9901 atggtgaaca aggtgtggag caccgatgca taccgacttc gcagtcgaat cacgacccca
     9961 ccacgaatag gaccagagag ttttcgcgaa gatgaccaac gtggctacct ctactcatcg
    10021 gatctcggct ccggccgccg ctgtccccac cggctcgaca ggccgaggac atgacgatct
    10081 gcggagcagg gtcgaccgcg cgctggcgac gttcctgcac cagcgaagag ccacgatcgg
    10141 tgcgacggtg cccgaattcg ccgaggcgat ggactcgctg atcgacctgg tgctcggcgg
    10201 gggcaagcga ctgcgtccca ccttcgcctg gtggggctgg cgcgcggcgg gcggcgatcc
    10261 gtcgtccccg gagtccgagg ccgtggtgcg tgcggtgagc gcgctggagt tgatccaggg
    10321 ctgtgctctg gtgcacgacg atctgatgga cgactcgccg cgacggcgtg gggcgcccac
    10381 catccatgtc gccttcgccg aacggcatcg ccgcgccggt tgggcgaccg cccccgaccg
    10441 cttcggaatg gccgccgccg tgctgctcgg cgatatctcc ctcgcatggg ccgacgacat
    10501 gctgcgcgag tccgggttgg acatcgaggc agcggcgcgg gcggtccagc cgtggcaggc
    10561 gatgcgcacc gagatgctcg cgggccagta cctcgacatg ctgtcgcagg ttcggtgtga
    10621 cgaggatccc gagaccgcgt tgcgggtcga tcggttcaag agcgccgcct acacggtgga
    10681 gcggccgctg catctcggcg ccgcgatcgc gggtggctcc tcggagatcg tgacgggatt
    10741 acgccacttc ggcaccgatc tcggagtggc cttccaactc cgcgacgacc agctcggcgt
    10801 cttcggcgac ccggccgtca cgggcaaacc ggcgggcgac gatctgcggg agggcaagcg
    10861 caccctgctg ttgtccgtcg gcctgcgccg ggcgagggag cgagcggacg acgcgagtac
    10921 gaagctgctt cgcgcggcca tcgggaatcc ggatctggac gaggacggcg tttcctcggt
    10981 gcgcaccgta ctgctgcggc tcggtgcggt cgccgagatc gagcgggaga tcgagcggtt
    11041 gaccgcgcgg gcgttgagcg tgttggaggc cactggaatc gacgccgtgg ccaaggaacg
    11101 gctcgtcgag ctgtcggcgg tcgccactcg gcgcaaccac tgatcggcgg accaggattc
    11161 ttcacccgtt aagtcgagag atcgatacgc agggtgatca attccatgcc tatggacaca
    11221 cgatcatgga atcaggacgg cggcagaccg aggctgacat ccggcctgtg ggaccatggg
    11281 gccgccatgc gcagccctga cgtacccagt acaaccgccg cgaccatctc ggcagcagga
    11341 cgcagcaccc tccaccggcc gaaccgcacc tcgagagaaa atgccttgag caactcgccc
    11401 gatcaacgcc gtctgatcca ccggctggcc gtcttccgca ggctggttcc gctacggatc
    11461 gtgttgctcg gcgctgcggg ctcggtgttg atcgcattgg gcgcggtggg tgcggccggg
    11521 gttctcaacc acgatccgct gctcgccgat tcgggcctca gctgggtgcg tttcggacac
    11581 ggccgcgatc tggccagcgg gctgctctat ctcggcctcg gtctgttggt ctgggcgtgg
    11641 gtgcggttgg gccgcgaggt acgcatcgaa cgagtcggca cccacggtgt gctggccacc
    11701 atcgcggggt ggctgctgcc gctgctgttc actccaccgc tgttcagtcg cgacgcctac
    11761 agctatctcg cgcagggaaa ccttgccgcg catggcatcg atccctatca gatgggcccc
    11821 gccgcgttgc ccggtccgct cgccgacaac gtgagctggg tctggcagaa cacccccgcg
    11881 ccgtacggac cgctcttcat cctggtgtcg atgctggtgg tgatggtcac cggccagcat
    11941 ctgatcctcg gcgtcctgtt gatgcgcctg gtgatggtgc tcggactcgt cctgctgtgt
    12001 tgggcgttgc ccaagctggc ccggctgctc ggcggcagac cggagcgcgc gttgtggctg
    12061 gccgccgcga atccgctgat gctggtccat ctggtcggcg ggccgcacaa cgatctgctg
    12121 atggtcgggc tgctcgcggc gggcgtcctg gtctgtctgc agggcagaca cgtctggggc
    12181 gtcgccctga tcacgatggc cgccgcgatg aaggcgacgg cggtgatcgc gctgcccttc
    12241 atggtgtggg tgtgggcggc ccgactccac ggatccccgc agtcgcggtt catccgcgcc
    12301 gcctcggcct cgctcgtggt ctcgttgggt gtcttcgcca cctgcacgct ggtcaccggg
    12361 gtggatctcg gctggatcgg cgcgctggag acgtcctcgc tcatcgtcaa ctggctgtcg
    12421 gttccgacgg cggtggcaca gatcgcggaa ctgatcggcg gttggttcat cgatctgagc
    12481 ctgcccagcc tgctggcgct gacccgcatg ttggggatgg tggcgttctt cttcgtcgcg
    12541 gtctggcagt ggtggaaggc cagacacggc gggctcgagg cggcggtcta ccgcgcgacg
    12601 atcacgctct tcgccctcgc tctgctctcc cccgccaccc tgccctggta cttcagctgg
    12661 ccgctggcac tgggtgcggt gttgaactgg ccgggtgccg ccaccgcggc cgccgtgtgc
    12721 ggctcggtgt ggctgctact ggtgaccttc cccagcggcg acacagcgct ctactcgtgg
    12781 ttctacctgc tgggcgcgct ggcggtgtcg gtgttggcgg ccgtctcgct ggtgcggccg
    12841 gacccgctgc ggctgtccag ccgtagcaag gtcgccgaca cggcgagcct gccgcccggc
    12901 tgaccgagta tccggaccgg ggcccgcccg acgacgactg cgcggcgggg ccgatgggca
    12961 cccgccgcta ctacgacttc atcacgaatc ttctgcgtcc gactcggcga ggaccggtca
    13021 gtagaaccgg tgacgcgcga cggtgccgtt gtaggtcaga acgccatcgc ctgcgcgcgg
    13081 cggcgaacct cgcggccccg gttctcgcgg agcgcggtga tcggccgacc gggcagtgtg
    13141 tcgtcctcgg tgaacagcca acgcatgatc tcgccgtggg agaacccgcc gtcacgcaac
    13201 accgtgacgg tcccgggcag gcccttgacg atgttctcct cgtcggtgag gaactcggcg
    13261 gggaccagcg ctacgccgtc acgacgtacg gcgagaagca gcccgtcccg caacatctgg
    13321 tggactcggg tgaaggggac acccaatcgt tcggcgacgt ccggcaacgg caggacctcc
    13381 acctcgggat cgagcacgtc cggggcggtg gggaactcac tcacgcaccg aacgatgcca
    13441 taaccgcgtc gcggccggtt tcaccgcctc gcctgcccac gcacgccgcc ctgccaccgg
    13501 gtcggtgggc ctccgtacga tcgcaggtgt gaaccgacgg gaggcgcacg tcatcggcac
    13561 gaccctcgaa ggcaggtacc ggatcgattc ggtcctggcc aggggcggga tgtcggtcgt
    13621 gtatcgaggt gtggaccttc ggctggatcg accgatcgcc gtcaaggtca tggatcagcg
    13681 cttctccggg gacgcggact tcgtccgccg gttcgagctg gaggccaggt cggcggcccg
    13741 gatccatcat tcgtcggtcg tcgccgtgca cgaccagggt gtcgaccaca cctccggtgg
    13801 cgagcaggtc ttcctggtga tggaactggt cgacggcggc acgctgcgcg atctgctgcg
    13861 cagccagggc acgctgtcgc ctgcggtggc gctgagcgtc ctggaacccg tgctgtcggc
    13921 cttggactcc gcacatcgcg cgggcatggt gcaccgggac gtcaaacccg agaacatcct
    13981 gatcagtcgg gacggcgtcg tgaaggtcgc cgatttcggt ctggtccgcg cgctggccga
    14041 cgccaagacg accagcgaca gcgtcatcct cggcaccgtc gactatctgg ctcccgagca
    14101 ggtcaccacc ggtgagaccg atgcgcgcgg cgatgtctac gccgcaggcg tggtgctcta
    14161 cgaactgctc accggggcac cgccgttcac cggggacacc ccgttctcca ccgcatatcg
    14221 acatgtcaac gatcgggtgc ctgcgccgag cgaacgagtc gccgaggtgc ccgccgcgat
    14281 ggacgccctg gtgctcgcgg ccacccgccg ggagcaggag gaacgcccgg cggacgcggc
    14341 ggcgttgttg gccaggctcc gcgagaccag ggcgacgctg ggactgtcga gtgtcgccgt
    14401 cccgggtgtc gttcccccgg ccggaccgac gtcggcggcc cctgggtcgg ctgcgggcgc
    14461 cgacgacggg acgatcgtca cccaggcggt aggcgggctg ccgcccgagt cgcccaaccc
    14521 ggcgagcggg atcgacggac cgacggtgcg caccccgctg cctgcgggcg ggcccgcccc
    14581 cgcgcggccg cccggccacc gggccaccca ggcgctgagt cgcaatgaac tgcccggcgg
    14641 tccgaacgac gcggcggcag gcaacgccgc gcatgccgcc cacctcggcg ggctcggcga
    14701 ccgaggtgac cgaggcaatc ggggccgccg aggcagacgc ggtaagccgg gcggcaaggc
    14761 aggtggcctg ttcagcaagg cgtccacccg gttgatcgcc atgggtgtcg ttctggtgtt
    14821 ggccctgctg ctctggtggt ggaacagcgc acagtggacg tcggtgcccg ccctggcggg
    14881 tatggaggtc gaggaggcgg aggactcgtt gaccgccgcc gagctggatg cccggctggt
    14941 ccacgtgccg cacaacgaca tcgcggcagg cgtggtcatc gactccgcgc cggatcaggg
    15001 acgtcggatt cgacgcggcg acgatgtgcg ggtgcgggtc tcctcaggtc tgcccaccgt
    15061 tcccgagatc actcccggta tcagtccgga cgaggccacc acgcagatcg aggatgcgga
    15121 gctcgaagtc gcgatcgacg aggaactggc cgagcacagc gccgaggtcg aggaaggggc
    15181 ggtgatccgg accgagccgg gtgcgggcac cgagctggag atcgacagca ccgtgacgct
    15241 gatcctgagc ctcggcccgc cgccggttcc ggtgcccgat gtcgccggtt cgtcccgaga
    15301 cgaggcattc gccgcgattc gagaggccgg attcgagccc tacgagctgg aggcggaatt
    15361 ctccgagagc gtcgacggtg gcgatgtgat tcgcaccgat ccgcccgccg agaccttgat
    15421 cgaaacgccg ggaacccgga ttggcgtggt gctgtccaat acgatcatcg ccccgtacgt
    15481 caccggtgat cgactgcggg acgtccgcca gacgatcgag gatctgggat tggaactgga
    15541 ggtccagcaa ttcttcggtg gcgacaatgc caggatcgtg gggcagttcc caccctcggg
    15601 cacccggctg cgccccggcg acgtcttcac cgtcaacact ttttgagcac gacgatgttc
    15661 aatccaggta aaaccttccc gcgcggccct tatgctcggg tcggctggac gacagccaag
    15721 atggagtgca catgatcggc gaccggggtc gggtaacagg aaagatcggc cccggattgg
    15781 tcggcgaggt gatgatcagc attcgcggcg gcgttgaggc gttctacgcc tatcccgccg
    15841 aggcaggcga ggtcatcgag ccgggcgagc aggtcctcgt ggttgatcat caaccacccc
    15901 gcagcgtcta cgtacaacgt tggctccccc ttggttgatc gtctcggtcg acggcgaccc
    15961 tgctcgccgt catctgtgac gtctacatct ggggagttgc cacatgccag acggtccgct
    16021 tctcatcgcc attctggtgg cggcgggaat cctcgtcttc gtcattctgc tgcgcgtttt
    16081 gtggaaggtc gccgagccga acgaggcatt gatcatctcc ggtttcggca ccgggtccac
    16141 cccgaagtcc aggccggaca gcatgggttt caagatcatc accggtaagg gcagcctggt
    16201 gctgcccggt ttccaggtgg cgcgcaggct ttcactggac accaatggtg ccaatctcca
    16261 ggtctcatgc gtcacccaac agggactgcc ggtgactgtt cgggcggtcg tcatatacaa
    16321 ggtcggcgat gatttcgtgt ccatcgccaa cgccgcccgt cgattcctcg atcgccagga
    16381 cgggatgaac agcaccattc acgagttgtt ctccggtcac cttcggtcga tctgcggtgg
    16441 cttgacgatc gaggatctga tccacaatcg ggatgcgctc accggtgcgg ttcggcagtc
    16501 ctccgccgac gagatgagca agctgggtct ggtcatcgat tccctgcaga tccaggagat
    16561 cgacgacgag tccggttaca tcctgaacct cggtaagcca cacgcggccg ccgtcgccgc
    16621 ctcggcccgg atcgccgagg cacagcgcga ccaggaggcc accgaggccg agcagcaggc
    16681 ggcggccaag aaggccgcgt cggtgcggga gagcgagatc cagcaggccg gttaccaggc
    16741 cgagatggac gaggcccgcg cacggagcag ccagtcggga ccgctggccg aggccagcgc
    16801 ccggcaggag gtcgtcgtcc aggagaccaa ggccgccgag ctggaggcca acctctccga
    16861 acagcggctg ctctcggaga tcagcaagcc cgccgacgcc aaggcgtacg agacgcggac
    16921 catcgccgag gccgagcgcg atgcgcggat cgccagggca caggccgagg cacgggagac
    16981 cgagcttcgg gcggctgccg acgcgacccg ggtcaagacg gcggcggagg cggaggcctc
    17041 ggccaccaag caacgcggtg tggcgcaggc cgacgcgacc agggccaccg gtgaggccga
    17101 ggccgcagcg gcgaaggcga agggtctcgc cgaggccgac gcggccaagg ccaagggtct
    17161 cgccgaggcc gagggcatcc gggcccgctc cgccgcgctg gcggagaacc aggaggccgt
    17221 cgtggcccag cagctggccg agcactggcc ggagatcgtc gacgcaggcg ccaaggcgtt
    17281 cagcagcatc gacaacctgg tggtgctcaa cggcgccgac gggatgtcgg atctgttcgg
    17341 caaggcactg tcgttgggcg gcaccggtct cgggttggcc aagacgctga tggagtccgt
    17401 gcagggcgac accccggcgg acaagtccga gacgaagggc tcgaccgcct ccgtgcagtc
    17461 gatcccggtc gaccgggacg agcactccaa gaactgaagg accgcgttcc tcagagaaac
    17521 cgaagcggtc accgtgcctc gcatcgcctg cgagtgggcg tcacggtgac cgcttcggcg
    17581 tgcccggccg gtctcgctcg atgggtgcaa gaccgcgagg ccgaaggccc cttactcgcc
    17641 gggcggcggg tgttcgtccg gttcctcggg atgggctcgg ttggcgacca aggggtcgtc
    17701 gtcggcgggc ggctccgggg tgagggcctc ctccgcacgg acgctgcgat tggctcgcgt
    17761 catgccctcg acctcgtgac tcagctcgtc gtccagccgg gctccgtgtt tatcgcttcc
    17821 gcgttgcacc acgatcgcct cctcgtctga gcggatccgg ttcgtctctt caccgaggca
    17881 tcgggaaccg cagcatcgcg ccgacaccgt cggggaccgc gtccaccggg tcgatgacga
    17941 acaggctcgc gtcggtggcc gcggcggcca gcgcgaccgc cgattcggcc cggcccaccg
    18001 cgacatcggc ggtcatctcc cccgccatgc tgttcgcatc ctgggcgccg aagctgatgt
    18061 cggtcgcctc ctctccgacc gtcacgtcgc ggtgcatccc gtcggagggc agcagcaccg
    18121 tctcgacggc gcccgcacgc aaggcggcga ccaccggttc cgggccactg acggccaatc
    18181 cctggcccgc gcccagctcc gattgaaatc gatcgaggac ctgctcggtc tcgtcggcca
    18241 ggaactcggc ggcgatgcgc tgcacctcct cggccagagc ggtccggtcg gagccagcgg
    18301 cccgcccgcc gtgttcggct tccaccgcga tggttcggct gcggctgggc agagcggcca
    18361 tgacctcggc tcgggcccgt acctcgcccg cgatcacgat cagtcgacta ccgatctcgg
    18421 cggcggcccg atcgacctcg tgcgcgatct ccgccgcgtt gtgcgcggcg gtgttctcca
    18481 ctcggcgctg cacccggttc tgcgaccagc ccagcccgcg caccttgtgc accggccgct
    18541 cgtcgccgcg aacggtgtgt tcccgccagc cgccgtcgcg gacgtgcacc ccgatgtcgg
    18601 cgccgacgcg gtccaccacc gcgaccacga ccggctcatc ggaggacacc gccaccaaca
    18661 gcgggaagac gtcgggaacc cgcgagtagg cggtcaccgt gttggcgggc ggttcgggca
    18721 gcacccggtc gagtaggacg gtgccgtctc ggccgaccac ggcccggcct gcccggccga
    18781 ccacccaggg ttcggagccg atcgcctcgt ccatcgccgc cagggtctcg gcgtcgacgc
    18841 ctcggtcggc gagttcctcc ccgaccgccc gacgccgcaa ggcgttggcc cggaatgcct
    18901 cctccgtgtc ccgggtgacg tcgaagtacg ccaccgcgca gggtcctgac ctggtggcga
    18961 gctctcgcaa caggcccagc tccatctcct tcacactccc ctcagtcggg gtaacccact
    19021 cgatcgacca gttcacccgg ccgacccaag caacgtcctt atcgcatacc ccgacggggc
    19081 tacgacgaca cgtattcgag gtggcgggcc ctgtcatgcg caccgagggc gacaccgacg
    19141 accagggcga cgagtggacc ggcggccggt cgggtacccc caaccgatga acatcgccta
    19201 gccacggact ggaggagtag agcgatgagc gaccgttccg agttcgaact gccgcagccc
    19261 ggtgccaccg acaacgagct gctctcggta ttcgaggagc tcgacgagga tgagctggac
    19321 gtcgatccgc tggagggcgg cgtcgacccg ccggagaact ggcagcggac gacctcctcg
    19381 ggggtgacac ccagggagat gttggagggc gagaccctcg acgcacgggt ggcggccgag
    19441 gtccccgata ccccgccgga ggaggagggc accgctcgac cagccgtgga gcgagagctg
    19501 gaggatctcg actcctcggt ggacgaggtc gtggaccacg gcgacgcggg tccggaggag
    19561 ggcatggagt tggagccgac cgaggtgggc cccactgggg aacccatcga ggacttcccg
    19621 gcgtggtccg gcgacccgtc cggagccgcc gaggacatgt cggttcaccc gaccaccgag
    19681 ctggactgac gccgaccgcg ccgccgccac cgggcgatgg cgacgacgcg gtcgaggcgc
    19741 ggcgcagaac tcagctggtg cgcaacagtt cgcgcaggac ctgcgggtag tcggtgatga
    19801 caccgtcgac acccaggtcg accgcggccg tcatgtcggc ttcctcgttg acggtccaga
    19861 cgttgatgtc cagccccagc gagtgcacct ggtcgaccaa ctcctggtcg acgagggtgt
    19921 agcgggggtt ggcctgctgc gcccaggtcg cggcgtcggc cagctccgcg tcggtggggc
    19981 gggcgccgaa cagcagaccg accgggacgc gcggcagctc gtcgtggaac tcgcgagtct
    20041 gctcgtggtc gaaggactgc acgaccagcg agtccaatgc cagggcacgc ggcaggtagc
    20101 cggggatctc gcggagaccg tcggcgaccg cctcgccgag gccctcctcg ccctcgcaga
    20161 ccttcacctc gagcagcagg tcggtgcgca ctcccagcgc gcggatgccc tcccgaaggg
    20221 tggggatcgg ctcgcccgcg aactccggcg acagccagga acccgcgtcg agctgcgcga
    20281 gctcgtcggc ggtgtagtcg ctcagcactc gggactcgcg gtcggggaag acctcttcga
    20341 cgttggtggt gcgctccagg gtgcagtcgt ggaacagcac cagttcgccg tcggcggtgc
    20401 gctggacgtc cacctcgacg gagtcggcgc ggtgctcgcg ggcggtggtg atcgcggcca
    20461 cggtgttctc gggcgcgacg ccggaggagc cccgatgcgc gatcacctcg gggccgcccc
    20521 ggtgattcgt ctcggccgcg ccggcgatcg gcgtggtgac acccaccatg agcagggaca
    20581 gcagaaggac cggccgcacc gaccgggcgg agagacgcat gagggttcct ttcgacgagc
    20641 tgtcgtggcg caatgtcgcc accgcgcacc ctgacagatc cgttatcgcc gccgataccc
    20701 cttctgtgga tctccgctgg tcggaacggc aggcgcccaa ccggcgaccg accggaccca
    20761 acaccaggcg ttctcgctgg tcaacggcgg tgcgggcggc ggatcgccgg acgataccga
    20821 acggctgtcc tgcgccttga cctgcgatga gtcgtcgcgc agagttcgcc tcgtcgatga
    20881 gccgagttgg ccgatcggac gccggcgcgg ctagctcacc acgggacgac ccccgcgtcg
    20941 tcgaagaaac cgcctcgggg cccgtcatcc ggcagcgtgg ccaacgcgat ggcgatcgcg
    21001 gcaccctgtt ctgggctcct cggcgcgtta tggccggtga agtcggtggc cacatagccg
    21061 ggacaggtcg cgttgacgat caccttggtc tcggcgagtc gacgggcgta ctgcgtcgtc
    21121 aggctgttga gcatcgtttt cga
//
