LOCUS       NZ_CP014859            45961 bp    DNA     circular CON 20-NOV-2024
DEFINITION  Actinoalloteichus hymeniacidonis strain HPA177 chromosome, complete
            genome.
ACCESSION   NZ_CP014859
VERSION     NZ_CP014859.1
KEYWORDS    RefSeq.
SOURCE      Actinoalloteichus hymeniacidonis
  ORGANISM  Actinoalloteichus hymeniacidonis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Actinoalloteichus.
REFERENCE   1  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J.,
            Zotchev,S.B. and Ruckert,C.
  TITLE     Complete genome sequence of the actinomycete Actinoalloteichus
            hymeniacidonis type strain HPA 177T isolated from a marine sponge
  JOURNAL   Stand Genomic Sci 11, 91 (2016)
   PUBMED   28031775
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J., Zotchev,S.
            and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2016) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Coverage                   :: 159x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001747425.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 01:17:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,434
            CDSs (total)                      :: 5,374
            Genes (coding)                    :: 5,337
            CDSs (with protein)               :: 5,337
            Genes (RNA)                       :: 60
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 3 of 37
            Pseudo Genes (incomplete)         :: 34 of 37
            Pseudo Genes (internal stop)      :: 1 of 37
            Pseudo Genes (multiple problems)  :: 1 of 37
            CRISPR Arrays                     :: 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:46:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4621931
            Orig. end                         :: 4667892
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014859.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..45961
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="oligosaccharide"
                     /region_number="21"
                     /rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /tool="antismash"
     cand_cluster    1..45961
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /kind="single"
                     /product="oligosaccharide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..45961
                     /aStool="rule-based-clusters"
                     /category="saccharide"
                     /contig_edge="False"
                     /core_location="[10000:35961]"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..35961
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
     misc_feature    complement(154..167)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     misc_feature    complement(266..281)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.32"
                     /tool="antismash"
     gene            462..1301
                     /locus_tag="TL08_RS19235"
                     /old_locus_tag="TL08_19485"
     CDS             462..1301
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673673.1"
                     /locus_tag="TL08_RS19235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19485"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_069850957.1"
                     /transl_table=11
                     /translation="MTEHTEPAAPLWEARGLTRRFRAPSGNRRGGAGLRTALSEVDLTV
                     REGEALGIVGESGAGKSTLLRLLLGLDRPDAGELHYRGAPLGTSRRALRDFRRDVQVVF
                     QDPRGSLNPRMRVSSIVAEPLRSLRIPGDHQARVREVLAEVGLGADAATRFPHEFSGGQ
                     RQRIAIARALAPRPKVLVGDEPVSALDVSVRAQILDLLGTLADQHAMTLVLVSHDLAVV
                     GRLCPRVLVLNQGRVVETGPTEQVYSTPTQDYTRRLLAAVPRLPEGTLSGAADRSTA"
     misc_feature    1062..1064
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1392..2213
                     /locus_tag="TL08_RS19240"
                     /old_locus_tag="TL08_19490"
     CDS             1392..2213
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019533.5"
                     /locus_tag="TL08_RS19240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19490"
                     /product="DUF1684 domain-containing protein"
                     /protein_id="WP_069850959.1"
                     /transl_table=11
                     /translation="MTQTVRDETAEREAWNAWREARRRRVIGAEGDLALVDTHWPETDS
                     RFAELPGAWSVRDDAVWLTATEQDGIHTRDGKPVIGELQVSAGEKPAPMLRFAGGSATV
                     VRRGEQFGIRRFDPQAVAIDEFEAIEAFDFAAAWHIPATFTKFATDTTVNYEKMLEDEP
                     VETAVPGELRFTVAGQEYVTTPMISGGRLMLVFADATTGVSSYQPGRFVLLDLPASTPG
                     EAVPVTIDFNRAYLPPCAFSAHYNCPLPPSGHRIAVSVEAGEKLIARKAAE"
     gene            2458..3318
                     /locus_tag="TL08_RS19245"
                     /old_locus_tag="TL08_19495"
     CDS             2458..3318
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672116.1"
                     /locus_tag="TL08_RS19245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19495"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_084643763.1"
                     /transl_table=11
                     /translation="MAASADRPDEARQADGAAEAKPEERPGGVRDVKSAARTLELLELL
                     AARQNRPARLRELSEALGMPRSSCYALLRTLAKYGWVRTDTSGTMYGIGIRALIAGTSY
                     LDTDPYLRIAKPVLDHLGEQLDETFHFGRLDGTDVVYLATRESGQYLRPYSRVGRRLPA
                     YSTSLGKALLAERDEHELGEHLPEVMTPLTPHTLTDRAALTEELTKVRERGYAVDQQEN
                     SVGLHCVALPMRYATPALDAISCSVPLARLTPAREADIIAAMRRAREEMERSATSVAMG
                     IAGGI"
     gene            3526..4470
                     /locus_tag="TL08_RS19250"
                     /old_locus_tag="TL08_19500"
     CDS             3526..4470
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (13-196). E-value: 1.5e-28.
                     Score: 91.8. Matches aSDomain:
                     nrpspksdomains_TL08_RS19250_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666553.1"
                     /locus_tag="TL08_RS19250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19500"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_069850960.1"
                     /sec_met_domain="ADH_N (E-value: 1e-09, bitscore: 36.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIGVYRYGGPEALHVLDLPEPQAGPGEVRIRVHAAAVSATDVL
                     LRTGGHAVRMPDRQPPFVPGMDAAGIIDQLGPEVDGRLWVGQRVIAMVLFVGPHGGAYA
                     EQVVVPAASVVPAPKDADFPAASTVLMNALTARLALDELSLSPGDTVAVTGAAGAVGGY
                     AVELARSDGLSVIADAAERDVDLVRGFGADRVVERGPEVAAGIRALVPEGVRGVVDGSL
                     QTAELLPALTDGGTLVELRGWSGPAERGIRVRPLMVTAGMEDTAKLDALRRQVDDGTLT
                     LRVAEVLPAEEAATAHRLVEAGGLRGRVVLDFS"
     aSDomain        3565..4113
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TL08_RS19250_PKS_ER.1"
                     /evalue="1.50E-28"
                     /label="TL08_RS19250_PKS_ER.1"
                     /locus_tag="TL08_RS19250"
                     /protein_end="196"
                     /protein_start="13"
                     /score="91.8"
                     /tool="antismash"
                     /translation="ALHVLDLPEPQAGPGEVRIRVHAAAVSATDVLLRTGGHAVRMPDR
                     QPPFVPGMDAAGIIDQLGPEVDGRLWVGQRVIAMVLFVGPHGGAYAEQVVVPAASVVPA
                     PKDADFPAASTVLMNALTARLALDELSLSPGDTVAVTGAAGAVGGYAVELARSDGLSVI
                     ADAAERDVDLVRGFGADRVV"
     gene            complement(4588..5331)
                     /locus_tag="TL08_RS19255"
                     /old_locus_tag="TL08_19505"
     CDS             complement(4588..5331)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005452433.1"
                     /locus_tag="TL08_RS19255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19505"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_069850962.1"
                     /transl_table=11
                     /translation="MTARTLEGKTALVTGGSRGIGAGIVARLAAEGANVAFTYASSKQR
                     AESVASAAIEAGGIAHAIHADSMREQDVADAVTATVDRFGGLDILVNNAGGGVFKAIED
                     LTMAEIDTMLTVNVRSVVVAIRESLPHLGEGGRIINIGSVNAVRNPFPGLSVYAMTKGA
                     IASLTNGLAKELGARGITINNLQPGPVDTEANPADGPNASNLLTAMSTDRFGTVAEISA
                     FVSYLAGPDAGYITGANLNIDGGFV"
     gene            5436..6029
                     /locus_tag="TL08_RS19260"
                     /old_locus_tag="TL08_19510"
     CDS             5436..6029
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF028235.5"
                     /locus_tag="TL08_RS19260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19510"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069850963.1"
                     /transl_table=11
                     /translation="MPRPRKFDEQAVLAAAQALFWRKGYADTSIQDLTEATGLRPQSLY
                     GAFGNKHELFLRILDDYRAWQSSELEAALAANPSPWNGLLQAVTFDSSESLALPPQGCL
                     MASSVSALSAKDEQVRQRAIESFDQALALFTRQIIRAQECGEVNDDLDAEQAARTLISI
                     RFGIEALHKSGIDEAELRRVKTAAVQMIERSVAR"
     gene            complement(6191..6664)
                     /locus_tag="TL08_RS19265"
                     /old_locus_tag="TL08_19515"
     CDS             complement(6191..6664)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159447.1"
                     /locus_tag="TL08_RS19265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19515"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_069850965.1"
                     /transl_table=11
                     /translation="MEHRFDLLKNQGSAKSLRHLVAAGKATLESTVPPETQELVRIRVS
                     QINSCAFCTDMHIKEALHAGEDAQRLHLVSVWRDANVFTEAERAALELAEQGTRIADAA
                     GGITDDAWANAAKHYDEEQLAALAALIAVMNAFNRMNVIAGNPGGDYQVGQFR"
     misc_feature    6648..6663
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.41"
                     /tool="antismash"
     misc_feature    complement(7096..7114)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.58"
                     /tool="antismash"
     gene            complement(7226..7645)
                     /locus_tag="TL08_RS29780"
     CDS             complement(7226..7645)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="TL08_RS29780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_318533328.1"
                     /transl_table=11
                     /translation="MVAVGIRCSRGPGGGGSAESQRAGLRSRCPEAGATQQHLADARQV
                     HIGLRQRQPASVRAELSNHSQPNGSCVEIGIGLEAADWRKSSRSTGTNGGCVEIGHASG
                     LVGIRDTKNRAGGTLSVSGTAFGSLILAIKEGNLR"
     gene            7820..8680
                     /locus_tag="TL08_RS19270"
                     /old_locus_tag="TL08_19525"
     CDS             7820..8680
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673107.1"
                     /locus_tag="TL08_RS19270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19525"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_069850967.1"
                     /transl_table=11
                     /translation="MTGPGGEQPRQQQRPPGVTKDMDPQPRDSMADYEGRGLLTDKRAL
                     ITGGDSGIGRAVAVAFAKEGADIAIAYLNEHDDAERTAELVRAEGKRCVLLPGDLAGAA
                     HCRDIVANTVQQLGGLEILVNNVATQWPLDAPEDLTEEQWLHTFDVNIHSYFRVTSAAL
                     PHLGDGAVIVNTGSVNGLRGNKSLIDYSATKGAIHAWTFSMAQALASRRIRVNCVAPGP
                     VWTPLIPSTFPPEKVKEFGLQVPFAEAAHPADLAPSYVFLASNRLSGYYSGEVIAALGG
                     ETTPG"
     gene            complement(8741..9349)
                     /locus_tag="TL08_RS19275"
                     /old_locus_tag="TL08_19530"
     CDS             complement(8741..9349)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013674547.1"
                     /locus_tag="TL08_RS19275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19530"
                     /product="flavodoxin family protein"
                     /protein_id="WP_069850968.1"
                     /transl_table=11
                     /translation="MSDIHALALVCSLKASPAPSSSELLAKQVLEQLATHKVTGESIRV
                     ADHDVRPGVETDMGEGDAWPEIRRKIAKADILLLATPTWLGHPSSIAQRVLERLDAALS
                     DTDDQSRPAMFGKVALAAVVGNEDGAHKIIADVFQALNDIGFSIPAQGSTYWNSEAMKP
                     VDYQDLDSTPAAVASTNATAARNAAHLARLLKTNQYPAG"
     gene            complement(9346..9792)
                     /locus_tag="TL08_RS19280"
                     /old_locus_tag="TL08_19535"
     CDS             complement(9346..9792)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226105.1"
                     /locus_tag="TL08_RS19280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19535"
                     /product="hypothetical protein"
                     /protein_id="WP_069850970.1"
                     /transl_table=11
                     /translation="MGSDDQTTPAVSRLLAEFDFDPRLRRPLAALGISPSTAVLLLDET
                     GLKVRFGLWRLQTPLANLRSATVGGPFQLFKVAGVRLSAADRGLTFGTGPGPGVCIRFH
                     RPVSAIEPFGIVRHPGLTVTVVDPAALADRVNRLHEPTSKRSAS"
     gene            10001..10975
                     /locus_tag="TL08_RS19285"
                     /old_locus_tag="TL08_19540"
     CDS             10001..10975
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: Glycos_transf_1"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333544.1"
                     /locus_tag="TL08_RS19285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19540"
                     /product="glycosyltransferase"
                     /protein_id="WP_069850972.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.4e-07,
                     bitscore: 28.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATRGLRVLLWHVHGSWTDSFVRGPHRCLLPTVEGGGEWGRGRC
                     GRDWRSAVEVPVTEIRESQPDVVILQRPQELDLVEQWLGRRPGKDIPAVYVEHNVPRAD
                     PVSARHPMADRPDIPIVHVTHFNDLMWDNGRAPTRVIDHGIVDPGDHYTGELPHGVALI
                     NEPTRRARVTGSDLLPMFAEAGPIDLYGIGAREFDTRQRGTHPVHGIDDLPHHRLHPEM
                     ARRRVYLHTARWTSLGLSLLEAMHLGMPVVSLAATEAPMAVPAEAGAVSTDISVLVRAF
                     HELLHEPDLAVLAGKAAREYALTRYGLDRFLRDWSALLDEVVR"
     gene            11008..12228
                     /locus_tag="TL08_RS19290"
                     /old_locus_tag="TL08_19545"
     CDS             11008..12228
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006237203.1"
                     /locus_tag="TL08_RS19290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19545"
                     /product="glycosyltransferase"
                     /protein_id="WP_069853916.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1e-41, bitscore:
                     140.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIAMISEHASPLAALGGVDAGGQNVHVAELSAALCRQGHQVTVY
                     TRREDPLVPEVVVTQPNCRVVHVPAGPARPLPKDLLLPYMGEFAAFLRAQWSVEPPDVV
                     HGHFWMSGLAAMLAVVGTEIPVVQTFHALGAVKRRYQGAEDTSPPERIPVEKLLAQQVA
                     HIIATCSDEVLELADLSVDGSRASVVPCGVDVDRFSPIGPRARLTEAHRIVSVGRLVPR
                     KGFDIAVAALAELPNTELVLAGGPDDGRLDEDPEAGRLRGLATELGVGDRLRMLGQVPR
                     GDMPGLFRSADVVVCTPWYEPFGITPLEAMACGVPVVSASVGGLMDTVVDGVTGTLVKP
                     RDPAELAAAVWDLLADPSRRRRYGLAGRQRVREGYCWDRVAEETLRAYRLVCAPSTEGI
                     GGGQAVV"
     gene            complement(12261..13157)
                     /locus_tag="TL08_RS19295"
                     /old_locus_tag="TL08_19550"
     CDS             complement(12261..13157)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: Glycos_transf_2"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944656.1"
                     /locus_tag="TL08_RS19295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19550"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_069850974.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.5e-17,
                     bitscore: 62.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGDRITLVIITCDRREQLLETLAQVTALPDAAPIVLVDNASSDG
                     TADAVAAAYPQVELIRADRNLGSLARNVAVRRIDTPYVAFCDDDTRWQPGALTRAVTLL
                     DRHPGLASVTGRCLVEPELAEDPLTPELRASPVRGPKWLPGPALLGVMAGLSAFRVSAF
                     RQVGGFSSRMWLGGEEELLALDLAARGWWMCWVEDMVIHHAPSRVRNARRRRQLGIRNT
                     LWTLWLRRPLRSVLRRSLVVLRSAPADRATLKAVLEALRGLPWVLRERQVVPVSVELGL
                     MRLEAQQRRSSARRYVG"
     gene            complement(13130..14035)
                     /locus_tag="TL08_RS19300"
                     /old_locus_tag="TL08_19555"
     CDS             complement(13130..14035)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: Glycos_transf_2"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333541.1"
                     /locus_tag="TL08_RS19300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19555"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_069853917.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-22,
                     bitscore: 79.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPRTTVVIATRNRAGELRHTLARLRALRPTPPIIVVDNASTDA
                     TAAAVAEVAGVRLIRLPANRAAAARNLGVVAATTPYVAFSDDDSWWAADALPAAERLLD
                     AHPSVGLLAARTLVGPGDTEDPINTLLATSPLGHQSELPGPSVLGFLACAAIVRRTAFL
                     RVNGFSRLLHFGAEERLLALDLAADGWDLCYAAELRAHHHPSTNRPPSAWRKDLERRNN
                     TLIAWMRRPLPRVAAETRLLLREGDRRQRSRIVAGLLRRLPSALWQRHRLPAEVERRVR
                     VLERAEERSRQPWAATASPS"
     gene            14254..15222
                     /locus_tag="TL08_RS19305"
                     /old_locus_tag="TL08_19560"
     CDS             14254..15222
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030302.1"
                     /locus_tag="TL08_RS19305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19560"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_084643261.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-10, bitscore:
                     38.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRIERALVTGGMGFVGSHLCELLLAEGSEVLILDNLVTAAPGT
                     VAEFGNRPNLRVDRQDVTEPITTPGPFDVVFHLASAASPQDYLRLPIETLRAGSLGTTH
                     ALDVALRDGARFVLASTSEVYGDPAEHPQRESYWGHVNPIGPRSVYDEAKRYAEALTNA
                     YRGHRGANTGIARIFNTYGPRMRPDDGRMVPTFIRQALAGLPMTVTGDGAQTRSLCYVA
                     DTARGLLALGRSDHPGPINLGNPVELSVGDLAAEVRSAAGSESPVTFVEAAEDDPRRRC
                     PDITLARRQLSWRPEVALADGLRRTIDWFEENTGIRAAHPA"
     gene            15342..16970
                     /locus_tag="TL08_RS19310"
                     /old_locus_tag="TL08_19565"
     CDS             15342..16970
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Carbam_trans_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009153199.1"
                     /locus_tag="TL08_RS19310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19565"
                     /product="carbamoyltransferase C-terminal domain-containing
                     protein"
                     /protein_id="WP_069850977.1"
                     /sec_met_domain="Carbam_trans_N (E-value: 1.4e-50,
                     bitscore: 171.0, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILGVNAVFHDPAAALVVDGHIVAAAEEERFSRRKHGKSPVPFS
                     TWELPEQAIAWCLHRAGLRPDQLDAVGYSYDPDLVDHSLGGLDPGSEELRTDYVRRAPA
                     FLRSAMPGLDPSIVRFVRHHVAHAASAALAAPFGDCAVLVADGRGESTSYVAGEYRDGK
                     FTEHAAQQLPHSLGLLYEDLTEHLGFARSSDEYKIMALASYGKPRFLDRFRELAYPTGD
                     GGFHTDPVSWTEFAPARHGSDTELDSAHADLAASVQRRIEEVWLDLATWLHDRTGAKNL
                     ALAGGIALNCVANTRLYAEGPFDQVWVQPASGDAGTALGAALQLSADLGEPTGPMPGAD
                     LGREWSDDEIEEILRVARVRYERPADVAVEVAQALADDQVVAWFQGRAEFGPRALGHRS
                     LLAHPGPTANLGRLNDVKGREQFRPVAPMVLADRAAEIFTRGPLPSPYMLFVHDVAADW
                     RDRIPTVTHVDGTARVQTVAPQHTPLLARMLREFEARTGLPVVVNTSLNTAGRPMVDSP
                     RDALECFGSAPVDLLAIGPFVVRRS"
     gene            16967..18466
                     /locus_tag="TL08_RS19315"
                     /old_locus_tag="TL08_19570"
     CDS             16967..18466
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: Glycos_transf_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333521.1"
                     /locus_tag="TL08_RS19315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19570"
                     /product="HAD-IIIA family hydrolase"
                     /protein_id="WP_069850978.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.5e-15,
                     bitscore: 54.6, seeds: 256, tool: rule-based-clusters)"
                     /sec_met_domain="HAD_2 (E-value: 4.3e-11, bitscore: 41.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDYSIVIPTTGRDNLWRLLTALRKADGPPPREIIVVDDRAEAFE
                     DLALPASAAQITLLRSGGRGPAAARNVGWRQATAEWIAFLDDDVITDARWPARLAADLT
                     GLDATVGASQARIEVPLPDDRRPTDDERGTAGLAGARWITADMAYRRTALAVVGGFDER
                     FTRAYREDADLALRVIEDGYAIVSGHRVTTHPARRSGVLASVRAQRGNADDVLMRRKHG
                     VRWRSRIGEGHGRLGWHAVTTAAGAAAGILFALGHRRAAAACGAGWAALTGRFAASRIA
                     PGPRTADEIGRMLLTSVLIPPVACWQRLRGELRYRTRRHRGDPPPLALLFDRDDTLIVN
                     VPYLADPEAVRPMPGARDALHWLRREGIRIGVVSNQSGVARGLISQTQLAAVNARVEEL
                     LGPIETWQICVHDTAEHCVCRKPAPGMVEQAARALGVDVARCVVIGDTGADVAAARAAG
                     ARAILVPTAATRQNEIDDAHRHARVARDLAEAVALALAGVR"
     gene            18463..19518
                     /locus_tag="TL08_RS19320"
                     /old_locus_tag="TL08_19575"
     CDS             18463..19518
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015785496.1"
                     /locus_tag="TL08_RS19320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19575"
                     /product="glycosyltransferase family 9 protein"
                     /protein_id="WP_069850980.1"
                     /sec_met_domain="Glyco_transf_9 (E-value: 5.9e-23,
                     bitscore: 79.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQRVLIARLDSLGDVLLAGPCIRAVAAGADSVTLLAGPLGAAAG
                     PLLPDLDEVLIWRAPWIDPQPEPVGPAAVAELVERIRAGRFDRALVLTSFHQSPLPLAL
                     LLRLAGVPWIGAICEDYPGSLLDLRHSVDGDPPESERALSLAEAAGFPLPAGDRGALAV
                     RRPLPEVAALTGPPGYVVVHPSASVPARQPSAARSAAIVEALLAAGHRVVVTGGTADRA
                     LTAEVATDRALDLGGTTTLAQLASVLDRASAVVVPNTGPAHLAAAVGTPVISLFAPVVP
                     AQRWAPHGVPTVLLGDQSAPCRGTRVRECPIVGHPCLESIQPDEVVTAVARLAEPTTGA
                     PQCRLTTGGVS"
     gene            19515..20078
                     /locus_tag="TL08_RS19325"
                     /old_locus_tag="TL08_19580"
     CDS             19515..20078
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030300.1"
                     /locus_tag="TL08_RS19325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19580"
                     /product="SIS domain-containing protein"
                     /protein_id="WP_069850982.1"
                     /sec_met_domain="SIS_2 (E-value: 1.9e-26, bitscore: 91.0,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEEHFAALCEALRRTDSAAPVLRQWAAQLARILPAGARLLACGN
                     GGSAAEAQHLTGELVGRFRDERQPLSAIALHADTSAGTAIINDYGGSELYARQVRAHGR
                     RGDVLVALSTSGSSENVVAAAKSAHDIGVTTWALTGPAPNPLAALCDDAITVDAPDVAT
                     VQEVHLALVHALCAALDGELGVTT"
     gene            20075..21454
                     /locus_tag="TL08_RS19330"
                     /old_locus_tag="TL08_19585"
     CDS             20075..21454
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659541.1"
                     /locus_tag="TL08_RS19330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19585"
                     /product="PfkB family carbohydrate kinase"
                     /protein_id="WP_069850983.1"
                     /sec_met_domain="CTP_transf_like (E-value: 4.9e-15,
                     bitscore: 54.3, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPLVVLGDALLDVDIEGTVERFCPGTPAAVVDVGGELRRPGGAG
                     LAALLASRSTAEVVLVTAIGDDDAGRTLIGLLDPVVEVLPLPLQGETVRKARVRVGNQS
                     LLRLDTGDGMASTAPVAQRVQSVLRGAGAIVVADYGRGVAAHPDIRRLLAELAATVPIV
                     WDPHPRGPAPTPGAWLISPNLEEARRFAPACGQDTELASVLCAEWAAGAVVVTTGADGG
                     MLAHGGRTTTVSVPEDARLLASVEADACGAGDCFAAAVAAGLILGQDVAAAVAGAVETA
                     ARFIGAGGAGALSISVEPRLTAAASRKLDSAFEIAARIRATGGRLVATGGCFDLLHPGH
                     VSLLRQSRALGDALVVCLNSDESVRLLKGEGRPIVPAQDRARLLTELSSVDAVAVFDEP
                     SPAALLERLCPDVWVKGGDYANAELPESRVVHGYGGETVLIPTVAGYSTSRLVAAAHAR
                     S"
     gene            21480..22169
                     /locus_tag="TL08_RS19335"
                     /old_locus_tag="TL08_19590"
     CDS             21480..22169
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-151). E-value: 5.1e-10. Score:
                     31.5. Matches aSDomain:
                     nrpspksdomains_TL08_RS19335_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226117.1"
                     /locus_tag="TL08_RS19335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19590"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_069850985.1"
                     /transl_table=11
                     /translation="MSTLGNIVITGGASGLGAATVEVVRENGGTPLVIDRAKPKSDVEF
                     VEADLSDTASAEAAVNELARRAGGRIDGVFTAAGTDACGTLDEVSVADWERVVHVNLLG
                     TVAVVRAALPFLKQSKGTVVTCGSTLGIKAVSDATAYCAAKFGVVGFTRALATETAGQI
                     GVTLLIPGGMHTAFFDNRTEQYKPPPDAKLNQPEDVARTVAFVLSQPPGCEIRELVVCS
                     SEESSWP"
     aSDomain        21495..21932
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TL08_RS19335_PKS_KR.1"
                     /evalue="5.10E-10"
                     /label="TL08_RS19335_PKS_KR.1"
                     /locus_tag="TL08_RS19335"
                     /protein_end="151"
                     /protein_start="5"
                     /score="31.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="NIVITGGASGLGAATVEVVRENGGTPLVIDRAKPKSDVEFVEADL
                     SDTASAEAAVNELARRAGGRIDGVFTAAGTDACGTLDEVSVADWERVVHVNLLGTVAVV
                     RAALPFLKQSKGTVVTCGSTLGIKAVSDATAYCAAKFGVVGF"
     CDS_motif       21501..21542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TL08_RS19335_0001"
                     /evalue="6.50E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="TL08_RS19335"
                     /protein_end="21"
                     /protein_start="7"
                     /score="9.2"
                     /tool="antismash"
                     /translation="VITGGASGLGAATV"
     gene            22160..23110
                     /locus_tag="TL08_RS19340"
                     /old_locus_tag="TL08_19595"
     CDS             22160..23110
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226116.1"
                     /locus_tag="TL08_RS19340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19595"
                     /product="glycosyltransferase family 9 protein"
                     /protein_id="WP_084643262.1"
                     /sec_met_domain="Glyco_transf_9 (E-value: 2.2e-31,
                     bitscore: 107.5, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVSDSVLVLRALGIGDLLTGIPALRALRRHHPDARLVLAAPENL
                     RALVDLIDAVDELLPTAGLGALHWSEAPPAVAVNLHGQGPQSIRDLRKVRPGTLLTHRH
                     PDYRGVPGLEWRDDVHEVDRWCRLLDFGGMDADRADLHLPRPAGSSPRPGAVVIHPGAA
                     YPARRWPPDRYVEVARALRSEGHEVVITGSPAEQDSATDIARAAGLPDSAVLAGRTDLA
                     GLARLVADATLVICGDTGVGHLATAFSTPSVLLFGPTPPKLWGPPATAEQHIALWVGDV
                     GDPHADRPHSGLLMLLPNRVLAAAHELLPDRVHHG"
     gene            23103..24419
                     /locus_tag="TL08_RS19345"
                     /old_locus_tag="TL08_19600"
     CDS             23103..24419
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020647019.1"
                     /locus_tag="TL08_RS19345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19600"
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="WP_069850987.1"
                     /transl_table=11
                     /translation="MVSHLGVVGAGYVGLTSAACLAHLGFRVTCVDNDVAKVDRLCAGE
                     VTIAEPGLADLVVAGRTRSRLDFTTDITTLAGVDLVLLCLPTPMGPDGACNLDVFESTL
                     AILGGVLRPGCVIVTKSTVPLGTAGRVPRLLGRADLPVVSNPEFLREGHAVEDFLHPDR
                     VVIGADAAYRDAAEEVAALYAETGAPVLHTDPATAEVTKYASNAFLAIKASYVNVLAEL
                     CERVGADVTEVTHAMGLDDRIAPDFLTAGPGWGGSCLPKDTSALLRAAEEAGVDFALVR
                     DAVKANARQQATVVRKVRCAVTGSADGSLVGARIGILGLAFKAGTGDLRDSPAIAIVEA
                     LARQGAILTAYDPAVGAAVGLGIHGVGVVSDPYLVAEDAAALVVLTEWPEFRTLDWTAL
                     ARAVRHPVVVDMRNVLDAAELATAGFRRVGLGTSAEPMA"
     misc_feature    24570..24585
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.87"
                     /tool="antismash"
     gene            24586..25443
                     /locus_tag="TL08_RS19350"
                     /old_locus_tag="TL08_19605"
     CDS             24586..25443
                     /NRPS_PKS="Domain: Abhydrolase_1 (23-271). E-value:
                     1.5e-12. Score: 39.6. Matches aSDomain:
                     nrpspksdomains_TL08_RS19350_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942437.1"
                     /locus_tag="TL08_RS19350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19605"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_236750335.1"
                     /sec_met_domain="PF00561 (E-value: 2.7e-10, bitscore: 38.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-11, bitscore:
                     43.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSHTLRDGRRLAWAEWGPSDGGPVLLCPGAATGRSLGFGGDDVD
                     TLGVRLVSLDRPGLGASDPAPGRTLTDWASDVSEVIEALELTTASGGRPSMVGFSQGAP
                     FALACAAAGLVSAVALVSPTDELAAPAIVELLPPQVRDLITMATTDPAAAEASFAGFAD
                     ATSMREMVTQMSGPVDRAVYTAPEFDAAYRRALAEGFAQGPAGYARDTLLSMSRWPFDP
                     AEITVPVTLWFGAHDTNPTHSPDLGRTLAERLPNAQRSELPDEGGSLLWKRAGEILRGV
                     VGAG"
     aSDomain        24655..25398
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TL08_RS19350_Abhydrolase_1.1"
                     /evalue="1.50E-12"
                     /label="TL08_RS19350_Abhydrolase_1.1"
                     /locus_tag="TL08_RS19350"
                     /protein_end="271"
                     /protein_start="23"
                     /score="39.6"
                     /tool="antismash"
                     /translation="PVLLCPGAATGRSLGFGGDDVDTLGVRLVSLDRPGLGASDPAPGR
                     TLTDWASDVSEVIEALELTTASGGRPSMVGFSQGAPFALACAAAGLVSAVALVSPTDEL
                     AAPAIVELLPPQVRDLITMATTDPAAAEASFAGFADATSMREMVTQMSGPVDRAVYTAP
                     EFDAAYRRALAEGFAQGPAGYARDTLLSMSRWPFDPAEITVPVTLWFGAHDTNPTHSPD
                     LGRTLAERLPNAQRSELPDEGGSLLW"
     gene            25827..29393
                     /gene="dnaE"
                     /locus_tag="TL08_RS19355"
                     /old_locus_tag="TL08_19610"
     CDS             25827..29393
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="dnaE"
                     /gene_functions="other (smcogs) SMCOG1194: DNA polymerase
                     III subunit alpha"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671416.1"
                     /locus_tag="TL08_RS19355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19610"
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="WP_257786067.1"
                     /transl_table=11
                     /translation="MSDSFVHLHVHTEYSMLDGAAKVAPLFAEAERLGMPAVGMTDHGN
                     MYGSAEFYRQAKKRDIKPIIGIEAYIAPVSRFHKKPVFWGESNQRSSDQSGEGGDVSGA
                     GAYTHMTMLAGNATGLRNLFKLSSLASYEGYYRKPRMDRELISEHAEGIIATTGCPSGE
                     VQTRLRLGQPREAMQAASDYRDIFGAENFFLELMDHGLPIERSVREGLLHIGRELGLKP
                     LATNDSHYVTQDQADTHGALLCVQSGKTLTDPTRFKFDGDGYYLKSADEMRAYWDTEVP
                     GATDSTLLIAERVESYDEVYAHVDRMPRFPLAEGETENSVLRAEVEQFTPARFPNGLTQ
                     EYQDRIERELGVIAQMGFPAYFLVVGDLVRWAKDQKIAVGPGRGSATGSLVAYILRITD
                     LDPIEHSLLFERFLNPERISMPDIDLDFDERRRGEVMDYTVEKWGAENVAQVITYGTIK
                     TKAAIKDAARVHYGQPGFSIADRISKALPPPVAAKDIPLAGIVDPSHERYAEASEIRSL
                     IQSDQEVSTIFETARGLEGLTRNAGVHACAVILSSQPLLDVIPLWKRDDGSIITGWDYP
                     ACEDIGLLKMDFLGLRTLTVIDDTIKEVERNHGIQIDLETLGLDDKASYELLSRGDTLG
                     VFQLDGAAMRDLLRRMQPKHFGDIAAVIALYRPGPMAANAHINYAERSNGRQKITPIHP
                     ELKDALEPILGETYHLLVYQEQVMAIAQQLAGYTLGGADLLRRAMGKKKKEVLEQEFEK
                     FNKGMLGNGYSEESIQTLWDVMLPFAGYAFNKSHTAGYGLVAYWTAFLKANYPTEFMAA
                     QLTSIGGDKDKSAVYLAECRRLGIKVLAPDVNDSGLHFAAVGKDIRFGLGAVRNVGANV
                     VQSIVSRRKEKGRYTSFTDFLDKAEIVACNKRVIESLVKAGAFDSFDTSRRSLFEHHEA
                     AVDAVIGLKRQEALGQFDLFGGGDEDGGASAEASPLAHLNFSSDEWPRKQLLAYEREML
                     GLYVSAHPLDGAERILRKHAPKAIATIVNEAPKEGEVVVAGMISSVDRRVNKQGEPWAI
                     VTIEDLDSAIEVLFFHKSYSVLHEDLIPDSSVAVKGRVNWREDKMSIFGSGVVQLDISA
                     AETNPGVAPAVMLRAEAHRLTRDVVGELRSTLLAHRGDAPLRLVLVHNDAEETYEVEKY
                     PVEFSGAFAAELKAIPGLTVVS"
     gene            complement(29411..30937)
                     /locus_tag="TL08_RS27600"
     CDS             complement(29411..30937)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="TL08_RS27600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_157421187.1"
                     /sec_met_domain="Asn_synthase (E-value: 4.5e-07, bitscore:
                     28.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKLQLAIVPDRPLWSWSSGRWTARCGWIEPLSNPALESLLVTDG
                     VRTAVIVRERMPDTAPWQGPISRIKPENWVNALDQLRRTSVEFVVVEFEWPAIRLHAGA
                     WGTAPLYLAARDSRLHASWDFDDLRPHIVSSELDFRELSRLLTRRHRYTRNTIARSVVQ
                     LTERSSVEFRAGSLESCYPQAAPRYRARSVGPDAPVLDAFDSLLGQAVRRREVTSESAV
                     AELSGGLDSALVALTLAAGSPGLASYGLSIEGEAAAQQRRRRAELVRFRSLRDVSIPAC
                     RPFDPAGPRAANPGEEPYAEALHRILMTSSEPVVFTGIGGDEMLALRSAERSDFGRRCA
                     QKPPRWLGHRAREQLPSIDEDLAPVSVLHETSLLAFACRNPIFLRAGRWPVSPLCDPEL
                     VLFGQWLPMDWRVSKRLARVWLERLGLSNDVVYPALRENFAGVMQRGLRLGGLSLAKQV
                     IEESVLVDLGLVDGDAMRAAVDEAEIEAVIDTSLYDFLAVERGLRSLLGA"
     misc_feature    complement(29576..29578)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(29597..29599)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(29957..29959)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    31056..31070
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            31541..32866
                     /locus_tag="TL08_RS19365"
                     /old_locus_tag="TL08_19625"
     CDS             31541..32866
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="TL08_RS19365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19625"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_157421188.1"
                     /transl_table=11
                     /translation="MRTALAHYDFGAVFLAVRSHTGMSQLELADLLGLSQSRVSAVERG
                     ERRLTHVKLAARMATALRIPAQRFGFPSRPDELDNAHVKEASWLERRDFLNLVTAAALG
                     SNLHPEISRLGELLPWSTEPVPRSRIGAADVDAIEAMTDGFRRLDLAHGGGFCRAAAIA
                     QLQQVRRLRDAICSPAVQTRLVVATAELASTAGWMAYDVDDHNTARRLWAFALAEAQHS
                     ANHPRAADLAVGLLLDMAHQALHLQRPDEALRLTQLASATASNRQFPVNVITEGYISTV
                     LGWCRASLDEPQAAVRAISQSQELYGRTEPGAVPPWASFVTDAEITAQQGHALYLLSLN
                     RPEFAAEAADQLTFAVDEYSADHERSRAMVLAPLACTHFRNGDLTAAVATGHQAVSAIA
                     ELSSTRGRARLRVLDAVAAPFAPAPEIIELRQRIHSFLHSAA"
     gene            complement(32915..33550)
                     /locus_tag="TL08_RS19370"
                     /old_locus_tag="TL08_19630"
     CDS             complement(32915..33550)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024701.5"
                     /locus_tag="TL08_RS19370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19630"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069850993.1"
                     /transl_table=11
                     /translation="MADDSGTTPTRTRNRRGEGGRLRDEIVAAATELLDETGDESAITL
                     RSVARRAGIAAPSIYRHFPDQPNIMLAVVQQIFAELAAKLHVAAAEAGDDPRRRLFAVC
                     DCYLDYAQQRPGRYRVMFGGVWMPALSETSVTADDMAALGDECMGLLGTVLGECVAAGY
                     STSNDLAVDTVALWLGLHGLAHQRAVTVAFPWPQDIAERVITSLAHLE"
     misc_feature    complement(33558..33573)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.55"
                     /tool="antismash"
     gene            33661..34698
                     /locus_tag="TL08_RS19375"
                     /old_locus_tag="TL08_19635"
     CDS             33661..34698
                     /NRPS_PKS="Domain: PKS_ER (22-343). E-value: 1e-40. Score:
                     131.7. Matches aSDomain:
                     nrpspksdomains_TL08_RS19375_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225521.1"
                     /locus_tag="TL08_RS19375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19635"
                     /product="medium chain dehydrogenase/reductase family
                     protein"
                     /protein_id="WP_069850995.1"
                     /sec_met_domain="ADH_N (E-value: 1.4e-05, bitscore: 23.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.2e-21, bitscore:
                     74.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTALTRTTEIVLPGEVEPTGLQVTERDLPAPAAGQVALRMEAT
                     GVSFAEQQMRRGKYYDQPPYPFVLGYDVVGTVTAVGARGDAAMVGHRYAAVTKIGGWAS
                     HLLLDAADLVAVPDEVGSAAAEAVAVNGVTAWQMLHRTAKVAEGGAIVVLGANGGVGSL
                     LVQLARQAGITVIGTASTRHHDLLRELGATPVDYREPDMYQRIRALAPEGVDAVFDHVG
                     GPGLTESWKLVRRGGTLVSYGTAATKDVAGNSQLPVLQSFARLGMWNALPNGKNAYFYN
                     FWAGRRDLDTFRARLRGDLTTVLRLVAEGVLTPQIAAEFPLNQAASALQLAESRTVAGK
                     VVIVA"
     aSDomain        33727..34689
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TL08_RS19375_PKS_ER.1"
                     /evalue="1.00E-40"
                     /label="TL08_RS19375_PKS_ER.1"
                     /locus_tag="TL08_RS19375"
                     /protein_end="343"
                     /protein_start="22"
                     /score="131.7"
                     /tool="antismash"
                     /translation="LQVTERDLPAPAAGQVALRMEATGVSFAEQQMRRGKYYDQPPYPF
                     VLGYDVVGTVTAVGARGDAAMVGHRYAAVTKIGGWASHLLLDAADLVAVPDEVGSAAAE
                     AVAVNGVTAWQMLHRTAKVAEGGAIVVLGANGGVGSLLVQLARQAGITVIGTASTRHHD
                     LLRELGATPVDYREPDMYQRIRALAPEGVDAVFDHVGGPGLTESWKLVRRGGTLVSYGT
                     AATKDVAGNSQLPVLQSFARLGMWNALPNGKNAYFYNFWAGRRDLDTFRARLRGDLTTV
                     LRLVAEGVLTPQIAAEFPLNQAASALQLAESRTVAGKVVI"
     CDS_motif       33781..33801
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TL08_RS19375_0001"
                     /evalue="7.10E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="TL08_RS19375"
                     /protein_end="47"
                     /protein_start="40"
                     /score="-2.5"
                     /tool="antismash"
                     /translation="RMEATGV"
     CDS_motif       33865..33903
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TL08_RS19375_0002"
                     /evalue="3.50E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="TL08_RS19375"
                     /protein_end="81"
                     /protein_start="68"
                     /score="10.4"
                     /tool="antismash"
                     /translation="LGYDVVGTVTAVG"
     misc_feature    34833..34851
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.69"
                     /tool="antismash"
     gene            34834..35961
                     /locus_tag="TL08_RS19380"
                     /old_locus_tag="TL08_19640"
     CDS             34834..35961
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020497349.1"
                     /locus_tag="TL08_RS19380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19640"
                     /product="glycosyltransferase"
                     /protein_id="WP_069850997.1"
                     /sec_met_domain="MGT (E-value: 2.5e-61, bitscore: 206.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRMLFSAVSAYGHILPLAPLMQAAVDAGHDVALLTSEGVRPLAAN
                     ELAAEVELLGVCAEAEDHIAEAARRSGGDPFHPTPEVIGEVFGNTRLILDAENGLSAAS
                     TWAPDLIVAELFDTVGPMIAARMELPWYQVGIGPALPAVLAGEIDRSVLPHYERAGVKP
                     VPAAGYLDTCPAALQDPEWVSEIPVLPVRVGAHRRPNPSGIELPRFTDPSKPTVLLTLG
                     TVFSEASTLAALCSAVAQADVNVLATLGVVLEESPEVTGRGEVRFVPFAPLEELLKDVT
                     LVVAAGGSGTVLGTLSRGIPLVLWPQGADQPINAARAAAAGVALVAGSADETSEAVARA
                     LQDEQLHTRAAQVAADNELRPTPAEIVATLTAGSR"
     misc_feature    34933..34935
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(35991..36004)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    complement(36186..36200)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.19"
                     /tool="antismash"
     misc_feature    complement(36207..36221)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
     misc_feature    36208..36219
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.99"
                     /tool="antismash"
     gene            36263..37744
                     /locus_tag="TL08_RS19385"
                     /old_locus_tag="TL08_19645"
     CDS             36263..37744
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005454609.1"
                     /locus_tag="TL08_RS19385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19645"
                     /product="multicopper oxidase family protein"
                     /protein_id="WP_069850999.1"
                     /transl_table=11
                     /translation="MAALFAGTLGAAGIYFLQARIDTVGAVDFDTELTIPPLAESEQDD
                     SGARVFDLTIQSGATEFVAGGATDTWGVNGTFLGPTIRAQRGERVEFAVTNDVDEETSI
                     HWHGMRLPAEMDGGPHQPIMPGETWRPHWTVDQPASTLWYHPHVHGKTAAHTYRGVAGM
                     FILDDENTASLNLPADYGVDDIPLIVQDRKFDADNQFDDSIPLGSTSGTLGDEILVNGS
                     HGPYREVTTRLVRLRLLNASNARMYNFGFSDDRPFQLIGTDGGLLPEAWETDRIQLSAG
                     ERAEIVVAFEPGDTVELRSYAAEFDLGDQTADRLSGEQDELDIVQFRAADALADETEIP
                     ETLAPAPDLGTENVAEVRTFDLEGRSINGQQMQMDRIDFGVREGDTEVWEVTNHNGYLH
                     NFHVHDVQFQVVDVDGVEPPPQLRGWKDTVLLVPDLRYRLAMRFSDHTDPNVPYMFHCH
                     LLTHEDEGMMGQFVVLGEDEEIGRVPQHGGHDHGD"
     misc_feature    36974..36976
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(37781..38743)
                     /locus_tag="TL08_RS19390"
                     /old_locus_tag="TL08_19650"
     CDS             complement(37781..38743)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012607.5"
                     /locus_tag="TL08_RS19390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19650"
                     /product="2-hydroxyacid dehydrogenase"
                     /protein_id="WP_069853920.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1e-49, bitscore:
                     166.6, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPTSEGIVLQTIPLLPSLTASLAANHRTVVLSEQDDPAAFLA
                     ERGAEVVAVVTTARIGVSHELMDALPNLGAIVHFGVGYETTDVARARSRGIDVSNTPDV
                     LTDCVADLAVGALIDVMRKLSAADRYVRRGDWKPGAYPLTTKVSGKRIGILGLGRIGQA
                     VARRLTGFDAEIVYHSRRPVAEASYRYVDSATTLAAESDVVVVTAAGGASTRGLVSEEV
                     LTALGPQGFLVNVARGSVVDEPALVAALVAGRIAGAALDVFVDEPNVPAELLGLDSVVL
                     LPHIASGTTETREAMGDLAFRNLHHFMAEGTLLTPVPTS"
     gene            complement(38924..40549)
                     /locus_tag="TL08_RS19395"
                     /old_locus_tag="TL08_19655"
     CDS             complement(38924..40549)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422619.1"
                     /locus_tag="TL08_RS19395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19655"
                     /product="aldehyde dehydrogenase (NADP(+))"
                     /protein_id="WP_069851000.1"
                     /sec_met_domain="Aldedh (E-value: 1.1e-42, bitscore: 144.5,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSTDASATATLTGSMLIGSQDVHGEQGTVFGVNPRTGQSLEPA
                     YGLGGAAEVARATRLAKEAFGVYRATSLEKRAAFLDTAAGNIDALGDVLVERVVAESGI
                     PEARVRGELARTVNQLRLFATTVRAGDWLGVRLDTPNADRVPLPKPDLRQRKVPLGPVA
                     VFAASNFPLAFSVAGGDTASALAAGAPVVVKAHSSHPGTSELVGRAIRAAVAEHGLPEG
                     TFSLLFGAGRELGTALVQDPAIAAVGFTGSRSGGLALVAAAAQRAVPIPVYAEMSSVNP
                     VVLLPGALAERGADLGREFIVSVTTGAGQLCTSPGLVFAVAGEGEDTGFDEFVAAARAA
                     VGLAPAAPMLTTGIQQAYQQGVEQLAARPGVTEVASGPTDEEIAACGQVGLYTTDGATF
                     LADESLRDEIFGATSLIVRVRDLDQLHEILTSLEGQLTATVHAQESDHPVVADLLPVLE
                     VLAGRVLFGGWPTGVEVGNAVVHGGPFPATSAPATTSVGTLAIERFLRPVSYQNVPDAL
                     LPVELRRENTLGLWRRIDGELGRD"
     misc_feature    complement(39935..39937)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(40546..41466)
                     /gene="kdgD"
                     /locus_tag="TL08_RS19400"
                     /old_locus_tag="TL08_19660"
     CDS             complement(40546..41466)
                     /EC_number="4.2.1.41"
                     /GO_function="GO:0047448 - 5-dehydro-4-deoxyglucarate
                     dehydratase activity [Evidence IEA]"
                     /GO_process="GO:0016052 - carbohydrate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="kdgD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672119.1"
                     /locus_tag="TL08_RS19400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19660"
                     /product="5-dehydro-4-deoxyglucarate dehydratase"
                     /protein_id="WP_069851002.1"
                     /transl_table=11
                     /translation="MTLYTPEELRTTLGTGLLSFPVTHATAELAFDEDGYRDHIAWLGS
                     YAASGLFAAGGTGEFFSLVPDEVGRIVRAAVAAMPGDKPVIAPAGYGTAQAVAMARDAE
                     AAGAHGVFLLPPYLTELSQDGLVEHVKAVCAATSLGVVVYHRANAAFGFDAVQRLADEC
                     PNFIGFKDGIGDVDLMTRIYARLGDRLLSIGGLPTAETYALPYLEMGVTTYSSAIFNFL
                     PEWAVEFYAAVRARDAETVYRKLDEFVLPYLDIRNRRAGYAVSIVKAGLTVIGRSAGPV
                     RPPLTDLTSAELDDLTALVTKVTKA"
     gene            41578..42468
                     /locus_tag="TL08_RS19405"
                     /old_locus_tag="TL08_19665"
     CDS             41578..42468
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672118.1"
                     /locus_tag="TL08_RS19405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19665"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_069851003.1"
                     /transl_table=11
                     /translation="MAAPFTLEQLRGFVAVAEEAHFGRAAARLQMTQPPLSRQVQKLER
                     SLGVDLLVRTTRAVLPTPAGEAFLTEARRILNLADAAPSAAQHAADGATGSLHIGFTAV
                     TALTVLGSWIKVANTRLPAVRLTLTEMVTRDQVEALLAGELSVGLVRGVAATDVLSVRR
                     VHAESLVLACPGGHPLTTLGRPPTLADVAEHAVITYSPVEARYLHELVITVFRNAGVEP
                     RYVQRIGQVQSLLALVDAGLGVALVPRSSSRLRLPNLAFTEIAGLAPDLVEAQCAWRSD
                     HDDPALAALLRLTAL"
     gene            42601..44181
                     /locus_tag="TL08_RS19410"
                     /old_locus_tag="TL08_19670"
     CDS             42601..44181
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012706.5"
                     /locus_tag="TL08_RS19410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19670"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_069851005.1"
                     /transl_table=11
                     /translation="MLSSVHRPVHIGRSRAKSGLAAMLVLACTATTACSVANSDSAGDA
                     GDAGDSLRIVLAQEPPTLEPCEASLTSTGVVTRSNISEPLIERDPTTGELEPLLATEWE
                     QDSDTEWTLQVRDDVTFHDGAEFTAEDAAFSIDRAVNSTLACNVEGYVFGDDDLGIEVV
                     DDTTLTITTARPDPILPLRLSFIEVVPRTTSTEAKVREPIGTGPYAVASWETGVSINLQ
                     RHDDYWGEAPDFGRVRYVWRSESSVRAAMIATDEADIATALNPEDATEENSLPYPNNET
                     TALRLDGTQAPLDDLRVRKAIGLAVDRHGIVDALFDGLAQPAAQLVPEGVVGYNPELTA
                     APADPEAARALVEEAADDGVPVDREITLIARNDMFPRVAETAEALQYQLAEIGLQVKIQ
                     MADTAAHLEYQLRPFPEDVGPVALLIMHGNQAGDAGFTTSQYLISDGPQSTFGTDALDE
                     QVAEADEALDDERQDAFAEVFAEQNESVAQYAHLAHMQGLLGISPRVSYEPNSATGDEM
                     RLADIRSQR"
     misc_feature    43072..43074
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            44193..45122
                     /locus_tag="TL08_RS19415"
                     /old_locus_tag="TL08_19675"
     CDS             44193..45122
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.5"
                     /locus_tag="TL08_RS19415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_19675"
                     /product="ABC transporter permease"
                     /protein_id="WP_069851006.1"
                     /transl_table=11
                     /translation="MLTFLRKRIVSSAIPLVVVVLGVFCLARLTGNPVNLYLPVSATAE
                     QRAAFSAANGFDQPIYIQLLDYLGQVVRLDFGVSLRTGQPAGEMVLAAFPATLQLAAVT
                     MVIAIVGAVLLGSLAAYRPNSPADRSASFLSMTAASIPDFWFAIMGVLILGVGLEWLPT
                     SGVDGGIEVWILPIATLLIRPFGVLVQVVRGAMVAALSAPYVKVARSKGASESRVVFGH
                     ALRNASVPALTVAGDLTIGLVNGAVVVETIFGWPGIGKLMIDSILQRDFAVLQAAVLLT
                     AVTIFVLNILIDVCYALLDNRVRQSVPA"
ORIGIN
        1 ggacggcagg ccgaggccga ggcggtcgag ctgtgcaggc gggttcgatt gcccgatccc
       61 gaggagtcgg cgcgggccta tccgcatcag ctgtccggcg ggcagcggca gcgcgtcggg
      121 ttggcgatcg ccttggcctg cgggccgagg ttgttgatcg ccgacgaacc gacgaccgcg
      181 ctggatgtca ccgtgcaggc cgagatcctg gatctgatca ccgagtcggt ggcggccgag
      241 ggcgccggtc tgctgttcat cagccatgac ctgccggtca tcgccaccgt cgccgatcgg
      301 atcgcggtga tgcgcgacgg cgggatcgtc gagcacggcg atctgcaccc ggtgttggcc
      361 gatccggagc atccgtacac ccgtgagctg ctgacggcgg cgctggcggc gggcagactg
      421 cccggcgatc cggtgcccga cgattcgtct ggggaggcac gatgaccgag cacaccgaac
      481 ctgcggcacc gctctgggag gcgcgcggcc tgaccaggcg gttccgcgcg ccgagcggca
      541 atcgtcgggg tggggcgggc ctgcgcaccg cgctgtccga ggtggatctg acggtgcgcg
      601 agggcgaggc gctgggcatc gtcggcgagt ccggggcggg caagtcgacc ctgcttcgcc
      661 tgttgctggg actggaccgg cccgacgcgg gcgagctgca ctaccgaggg gccccgctgg
      721 gcacgagtcg ccgcgcgctg cgggacttcc gccgggacgt gcaggtggtg ttccaggacc
      781 cgcgcggttc gctgaaccct cggatgcggg tgtcgtcgat cgtggcggag ccgctgcgca
      841 gcctgcggat tcccggcgat caccaggcgc gggtgcgcga ggtgttggcg gaggtcgggt
      901 tgggcgccga cgcggccacc cgctttccgc acgagttctc cggcggacaa cgccaacgca
      961 tcgcgatcgc cagggccttg gcgccccggc cgaaggtgct ggtcggcgat gaaccggtga
     1021 gtgcgctgga tgtgtctgtg cgggctcaga tcctcgacct gttaggcacc ctggccgatc
     1081 aacacgccat gacgctggtg ctggtctcgc acgatctggc ggtggtcggc cgattgtgtc
     1141 cgagggtgct ggtgctgaat cagggccggg tggtggagac gggcccgacc gagcaggtct
     1201 attcgacgcc gacgcaggac tacacccggc ggttgttggc ggccgtgccg aggctgcccg
     1261 agggcacgct gtccggtgcg gccgatcgca gcacggcgta gcggcccggc cggagcgctt
     1321 ggtgctgcgg cgggttcgcc tccgccgtgg cgcgcctgtt ggaatggcag ccgacgacaa
     1381 ggagcttgga tatgacgcag acggtccgcg acgagacggc cgagcgcgag gcgtggaacg
     1441 cgtggcggga ggcccggcgg cggcgggtca tcggtgccga gggggatctg gcgctggtgg
     1501 acacccattg gcccgagacc gactcgcgat tcgccgaact gcccggcgcc tggagcgtgc
     1561 gggacgacgc ggtgtggctg acggccaccg agcaggacgg gatccacacc cgcgatggca
     1621 agccggtgat cggtgaactc caggtttccg ccggtgagaa gcccgcgccg atgctgcgtt
     1681 tcgccggcgg gagcgccacg gtggtccggc ggggcgagca gttcggcatc cgacgcttcg
     1741 acccgcaggc agtcgcgatc gacgagttcg aagccatcga ggccttcgat ttcgcggccg
     1801 cgtggcacat ccccgcgacc ttcacgaagt tcgcgacgga caccacggtc aactacgaga
     1861 agatgctgga ggacgaaccc gtcgagaccg ccgtgcccgg cgaactccgc ttcaccgtgg
     1921 ccggacagga atacgtcacc acgccgatga tctccggcgg ccggctgatg ctggtgttcg
     1981 ccgacgccac gaccggcgtg agcagctacc agccgggccg cttcgtgctg ctcgacctgc
     2041 ctgcttccac gccgggcgag gcggtgcccg tgaccatcga cttcaaccgt gcctacctgc
     2101 cgccgtgtgc gttctccgcg cattacaact gcccgctgcc gccgtccgga catcggatcg
     2161 cggtgtcggt ggaggcaggc gagaagctga tcgcacgcaa ggcagccgaa taggcgtctc
     2221 gtcgtcgtgc cgaggcggga ggcggccggg tggttgcttc ccgccggttg atcgaacagg
     2281 tcagcggcgg tgtggctcgg ttgctcggct gattcgggcg ggcgttgatc tctggtccat
     2341 tcggcggtct tgagtgagcc aacgggcttc agaggtaacg tgggacaacc gttcggcagt
     2401 tcgcccgggt ccgcgccgac cccggacgga tcagcgttcg accaggaggc tcacttcatg
     2461 gctgcatcgg ccgaccgtcc agacgaggca cggcaggcgg atggcgcggc cgaagccaag
     2521 cccgaggagc gccccggcgg ggtccgcgat gtgaagtcgg cggcccgaac cctggaactg
     2581 ctcgaacttc tggccgcccg gcagaaccgc cccgcccgac tccgcgagct gagcgaggcg
     2641 ctcggcatgc ccaggagcag ttgctacgcg ctgctgcgca ccctggcgaa atacggctgg
     2701 gtgcgcaccg acacctccgg cacgatgtac gggatcggaa tccgggcgtt gatcgcgggc
     2761 accagctacc tggacaccga tccgtacctg cgtatcgcaa aaccggtgct cgaccacctg
     2821 ggtgagcagc tcgacgagac cttccacttc ggcaggctcg acggcaccga cgtcgtctac
     2881 ctcgccaccc gcgagtccgg ccagtatctg cgcccctaca gccgggtcgg gcgcaggctt
     2941 ccggcgtatt cgacgtcgct gggcaaggcg ctgctcgccg aacgcgacga gcacgaactc
     3001 ggcgagcatc tacccgaggt catgaccccg ctgaccccac acaccctgac cgaccgcgcc
     3061 gcactcaccg aggaactgac gaaggtccgg gaacgcggct acgccgtgga ccagcaggag
     3121 aacagcgtcg gcctgcactg cgtcgcccta ccgatgcgct acgccacgcc tgccttggac
     3181 gcgatcagct gttcggtgcc gttggcccgg ctgaccccgg cccgcgaggc cgacatcatc
     3241 gccgccatgc gccgggcccg cgaggagatg gaacgctcgg cgacctcggt ggccatggga
     3301 atcgcgggcg ggatctaacc gccgcagacg gtgtgccgag cctcgaacca cggtgcgcag
     3361 ggcgtccgag tatccgaacc ggggcgggca gtgctgtcct cgttggcgcg gggttccggg
     3421 ggtgcagcgg tgccagccga tgcggccggt tcccacccag cgagacaccc cggacccacg
     3481 cacgtcgccg gaatagcgtc ggatcgcggc gctttgtatc ggcatgtgaa ggcgattggg
     3541 gtttaccgct acggcgggcc ggaagcgcta cacgttctcg atctacccga accgcaggcg
     3601 ggaccaggtg aggttcgcat ccgggtgcat gcggcggcag tgagcgccac cgatgtgctg
     3661 ttgcgcaccg gaggtcatgc ggttcgcatg ccggatcggc aaccgccgtt cgtgccgggg
     3721 atggatgccg ctggcatcat cgaccagctg gggccggagg tcgatggacg gctctgggtg
     3781 gggcagcggg tgatcgcgat ggtcttgttc gtgggcccgc atggcggtgc ctatgccgag
     3841 caggtcgtgg tgcctgccgc atcggtggtc cccgctccga aggacgccga tttcccggcc
     3901 gcgtccactg tgctgatgaa tgctttgacg gcacggctgg ccttggacga actgtcgttg
     3961 tcccccggcg ataccgtcgc ggtgaccggg gcggccggcg ccgtcggcgg ctacgccgtg
     4021 gaattggcgc gcagtgatgg gttgtcggtg atcgccgacg ccgccgaacg tgatgtcgac
     4081 ctggtccgtg ggttcggggc cgaccgggtc gtcgaacgtg gtcccgaggt ggccgccggt
     4141 attcgtgcac tggtgcccga gggtgttcgc ggcgtggtgg acggctcgtt gcagaccgcc
     4201 gagctgcttc ccgcactcac cgatggtgga acgctggtcg agttgcgtgg ctggtcgggt
     4261 ccggcggaac gcggtatccg ggtgcgtccc ttgatggtga ccgcagggat ggaggacacc
     4321 gcgaagctgg atgcgctgcg gcgccaggtc gacgacggca ccctgacgct gcgggtcgcc
     4381 gaggtgttgc ccgccgagga ggcggccacg gcgcatcgac tggtggaggc gggcgggctg
     4441 cgcggtcggg tggtgttgga cttctcctga tccgcgcagc cgccgcgaat cggacgcgcc
     4501 aggacaccga ctacgcaatg ccgcggtcgc tgtcctggcg tgccgtcatc tcctactcgc
     4561 accgacgggc gacgtgatct cccctggtca cacgaatcca ccgtcgatgt tcaggttggc
     4621 accggtgata tagccggcgt cgggcccggc gaggtaggac acgaaggcgc tgatctccgc
     4681 cacggtgccg aagcggtccg tcgacatggc tgtcagcagg ttcgacgcgt tgggcccgtc
     4741 ggccgggttg gcctcggtgt ccaccgggcc gggctgaagg ttgttgatgg tgatgccacg
     4801 cgcgcctagt tccttcgcga gtccgttggt caggctcgcg atcgcgccct tggtcatggc
     4861 gtagaccgac aggcccggga acggattgcg gaccgcgttg acgctgccga tgttgatgat
     4921 tcggccgccc tcgcccaggt ggggcaggga ttcgcggatg gcgaccacga cggaccgcac
     4981 gttgacggtg agcatggtgt cgatctccgc catcgtcagg tcttcgatcg ccttgaagac
     5041 gccgccgccc gcgttgttga ccaggatgtc cagtccgccg aatcggtcga cggtcgccgt
     5101 gacggcgtct gccacatcct gttcacgcat gctgtcggcg tggatcgcgt gtgcgatgcc
     5161 gcccgcctcg atggccgccg aggccacgga ctccgcgcgt tgcttcgagc tcgcgtaggt
     5221 gaacgccacg ttcgccccct cggcggccag ccgagcgacg atgcccgcgc cgattccacg
     5281 ggaacccccg gtcaccagtg cggtcttgcc ttccagcgtt cttgcggtca tgttctgtcg
     5341 cccccaatat ttttgagtga tcactcaata aatgccatca cggggtccgc ttgtcaaact
     5401 tgagggctcg ctcaacaatc gatagggtcg cgcccgtgcc ccggcctcgg aagttcgacg
     5461 agcaggccgt gctcgccgcc gcccaagccc tcttctggcg caagggctac gccgacacct
     5521 cgatccagga cctcaccgag gcgacgggac tccggccgca gagcctgtac ggggcattcg
     5581 gcaacaaaca cgaactgttc ctgcggatcc tggacgacta ccgggcctgg cagtccagcg
     5641 agttggaagc ggcactcgcc gcgaatccga gcccgtggaa cggcctgctc caggcggtca
     5701 ccttcgacag cagcgagagc cttgcactgc cgccccaggg ctgcctgatg gccagcagcg
     5761 tctccgcgct gagcgccaag gacgagcagg tccgccagcg cgcgatcgag tcattcgacc
     5821 aggccctcgc actgttcacc cggcagatca tccgtgccca ggagtgcggc gaggtcaacg
     5881 acgacttgga cgccgaacag gccgcccgga cgctgatctc catccgattc ggcatcgagg
     5941 ccctgcacaa atcggggatc gacgaggccg aactacgtcg ggtcaagacc gccgccgtgc
     6001 agatgatcga acggtctgtc gcacgttgac ggtggggatc gcacgctcgc aggcgagcag
     6061 atcgagcacc ccgaaccgcc aggcccgcaa cgtcgcgacc ggaccggccg acgtcgttgc
     6121 gggcgagatc acgtcatccc gtgatcaggg ctgattcaga cattccagcg gctggccgac
     6181 gcaggtcgcg tcagcggaac tggccgacct ggtaatcgcc gcccgggttc ccggcgatga
     6241 cgttcatccg gttgaaggcg ttcatcacgg cgatgagcgc agcgagggcc gccaactgtt
     6301 cctcgtcgta atgcttggcg gcgttcgccc aggcgtcgtc ggtgatgccg cccgccgcgt
     6361 cggcgatgcg ggtgccctgc tcggccagtt ccagcgccgc ccgctcggcc tcggtgaaca
     6421 cgttggcgtc ccgccacacc gagaccaggt ggagccgctg ggcgtcctcc cctgcgtgga
     6481 gcgcctcttt gatgtgcatg tcggtgcaga aggcgcagga gttgatctgg ctgacccgaa
     6541 tgcgcaccaa ctcctgcgtc tcagggggca cggtcgactc aagggtcgcc ttccccgccg
     6601 caaccaggtg ccgcaacgac ttggcggaac cctgattctt caagagatcg aaacgatgtt
     6661 ccacgatgca ctcccttgcc gttcttgctg gatacaccgt gttgaccagg tggcccggcg
     6721 aaacctgaca gagatggaag tgacgtgggg cacagatccc gatgatcttg cttggcggac
     6781 tttgtggttg tgtatgggtg ccccgcgtgc gcggggcaga cgtgatgcgt gctcgcggcc
     6841 ggagccggag tgtcggaaca cccccgcgtg cgcggggcag acactccaac gtcggcaagg
     6901 tcgacatgaa gcgcaggaac accccgcgtg cgcggggcag accgctctgc agggacaact
     6961 cggctcccgt ggtgaggaac acccccgcgt gcgcggggca gaccccgcgc tgcgtcggac
     7021 ggctcacccg cgcccgggaa cacccccgcg tgcgcggggc agacacttcc tgacctggtg
     7081 ttctactggc gggtaacagg tttttcgtcc actaggttct gagccctgcc ctgagaattg
     7141 aagcccatcg aactctcgac caagaggacg agcaacacgc tcgaaccact agacatcgac
     7201 ggtccggcaa cgcactcacg caggcctagc gaaggttgcc ttccttgatg gcgaggatta
     7261 gagagccgaa cgctgtcccg ctcacggaga gcgtgccacc cgcacggttc ttagtgtcgc
     7321 ggatgccgac gagtccggag gcgtgaccga tctcgacgca accgccgttg gtgccggtac
     7381 tacggctgga tttccgccag tccgcagcct ctagcccgat cccgatctct acacaggaac
     7441 cattcggctg gctgtggttc gatagttcgg cgcgcaccga tgcgggctgg cgctgtcgca
     7501 gtccgatgtg gacctggcga gcgtcagcga ggtgctgctg tgtggcacct gcctcggggc
     7561 accgactccg cagaccagcg cgttggctct cggcactacc accgcctccg ggcccgcgtg
     7621 agcaccggat tcccacggcg accacccgtt atgccgctgc ggcaaccgct cgtgactcgt
     7681 ttctcccctg cctgcaccgg gtatctgggc agttgggtcc gcgtgatttc ggcaccgagc
     7741 gactgcaacc gacgccgagg tgatcgcgcg gcgcgatgtc ttccaggcag cgcaaccgag
     7801 ccggagagga gaacccccga tgactggtcc aggcggggaa caacctcggc agcagcaacg
     7861 gccgccgggt gtcaccaagg acatggatcc gcagccccgt gattccatgg ccgactacga
     7921 gggtcgcggg ctactgaccg acaaacgcgc attgatcacc ggcggcgact ccggcatcgg
     7981 ccgggccgtc gcggtggcgt tcgccaaaga gggcgccgac atcgccatcg cctatctcaa
     8041 cgaacacgac gacgccgagc ggacggccga actcgttcgc gcggagggaa aacgctgcgt
     8101 gctgctgccg ggtgacctag cgggcgccgc gcactgccgt gacatcgtgg cgaacaccgt
     8161 ccagcagctc ggcgggctgg agatcctcgt caacaatgtt gcgacgcaat ggccgctcga
     8221 cgcgccggag gacctcaccg aggaacagtg gctgcacacc ttcgacgtca acattcacag
     8281 ctacttccgc gtcaccagcg ccgcattgcc gcacctcggt gacggcgcgg tcatcgtgaa
     8341 caccggttcg gtgaacggcc tgcgtggcaa caaatccctg atcgattact cggcgaccaa
     8401 gggcgcgatc cacgcctgga ccttctcgat ggcgcaggcg ttggcgagcc gacggatccg
     8461 cgtgaactgc gtggcgcccg gtccggtgtg gacgccgttg atcccgtcca ccttcccgcc
     8521 ggagaaggtc aaggagttcg gtctacaggt tccgttcgcc gaggccgcgc accccgccga
     8581 cctcgcgccg tcctatgtgt tcctcgcctc gaaccgactc tcgggttatt acagcggcga
     8641 ggtcatcgcc gcgctcggcg gtgagaccac ccccggctga cccgacgccg agcgcgcgga
     8701 cgattcttcg ggtgcgcgct cggcatcggc cgccagcgag ctatccggcc gggtactggt
     8761 tcgtcttcag caagcgggcc agatgggcgg cgttgcgcgc ggcggtcgcg ttggtggagg
     8821 ccaccgcggc gggagtggag tcgaggtcct ggtagtcgac cggcttcatg gcctcgctgt
     8881 tccagtaggt ggagccctgc gcggggatgc tgaacccgat gtcgttcaac gcctggaaca
     8941 cgtccgcgat gatcttgtgc gcgccgtcct cgttgccgac gaccgcagcg agggcgacct
     9001 tgccgaacat ggcgggcctg ctctggtcgt cggtatcgga cagcgcggcg tcgagacgtt
     9061 ccaggactcg ctgcgcgatg ctggatgggt ggccgagcca ggtcggggtg gctagcagca
     9121 ggatgtcggc cttggcgatc ttccgtcgga tctcgggcca ggcatcgccc tcgcccatgt
     9181 cggtctccac gcccggccgc acgtcatgat cggcgacgcg gatcgactcg ccggtcacct
     9241 tgtgggtcgc gagctgctcc aacacctgct tggccagtag ctcgctgctg gagggcgccg
     9301 gggatgcctt caggctgcac accagggcca gtgcgtggat atcgctcatg aggcactccg
     9361 tttcgaggtc ggttcatgaa gtcgattcac ccggtccgcg agcgcggccg gatcgacgac
     9421 ggtcacggtg aggccggggt gacggacgat gccgaagggt tcgatggcgg agaccggtcg
     9481 gtggaatcgg atacacaccc cgggaccggg gcccgtgccg aaggtgaggc cgcgatccgc
     9541 cgccgacagc cggacaccgg cgaccttgaa cagctgaaac ggcccgccaa ccgtggcgga
     9601 gcgcagattc gccagcggtg tctgcaaccg ccagagtccg aagcgcacct tcagcccggt
     9661 ctcgtccaac agcagcacgg cggtgctcgg ggagatcccg agtgcggcca gcggcctgcg
     9721 gagcctcgga tcgaagtcga actcggccaa cagccgggat accgccggag tcgtctggtc
     9781 atcgctgccc atgcggcatg gctacccgct gcggacccgc cgaaccgcct ccggccgcgg
     9841 gcatcgactg ccgatggggc cgctgttcgt cgccgatacc gctgtgagcc agggggctgg
     9901 tgggacggtg cgttatctgc cccaaacccg tgttgcgctg ggaaaaccag tacccacctg
     9961 cagacgtttc gggccggtgc ccagcggtaa ctgctaggac gtgaccgcga cccggggcct
    10021 gcgcgtgctg ctgtggcatg tgcacggctc gtggaccgac agcttcgtgc gcggcccgca
    10081 tcgatgcctg ttgccgaccg tggaaggcgg cggcgaatgg ggtcgaggcc gctgcggccg
    10141 ggactggcgc tctgccgtcg aggtccccgt gaccgagatc cgcgaatcgc aaccggacgt
    10201 ggtgatcctg caacgcccgc aggaactcga cctcgtcgaa cagtggctcg gtcgacgtcc
    10261 cggcaaggac atccccgccg tctacgtcga gcacaacgtg ccccgcgccg acccggtgtc
    10321 cgcccggcat ccgatggccg accgaccgga catcccgatc gtgcacgtca cccacttcaa
    10381 cgacctcatg tgggacaacg ggcgcgcacc cacccgagtc atcgaccacg gcatcgtcga
    10441 ccccggcgac cactacaccg gtgaactgcc gcatggcgtt gccctgatca acgaaccgac
    10501 ccggcgggcc cgggtgacgg gcagcgacct gctgccgatg ttcgccgagg cgggtccgat
    10561 cgacctgtac ggcatcgggg cgcgggagtt cgacacccgg caacgcggca cccatccggt
    10621 gcacggcatc gacgatcttc cccatcaccg gctgcatccc gagatggccc ggcggcgggt
    10681 ctacctgcat accgcacggt ggacctcgct cgggctgtcg ctgttggagg ccatgcacct
    10741 cgggatgccg gtggtgtccc tggctgccac cgaggccccg atggccgtgc ccgccgaggc
    10801 gggggcggtg tccaccgaca tctcggtact ggtccgcgcc ttccatgaac tgctgcacga
    10861 acccgatctc gcggtgctgg cggggaaagc ggcccgcgaa tacgccctca cccgatacgg
    10921 gctcgatcga ttcctgcgcg actggtcggc gctactcgac gaggtcgtcc ggtgagtcgc
    10981 gcgcacggcg tcggcggcgg agaccggctg cgcatcgcga tgatctccga gcacgccagc
    11041 ccgttggccg ccctcggcgg ggtggacgcg ggcgggcaga acgtgcacgt cgcggagttg
    11101 tcggctgcgt tgtgcaggca gggccaccag gtcacggtgt acacccgccg cgaggatccg
    11161 ctggtgcccg aggtcgtcgt cacccaaccg aactgtcgag tggtgcacgt accggccggt
    11221 ccggcccgac cactgcccaa ggacctgctg ctgccctata tgggcgagtt cgcggcgttc
    11281 ctgcgcgcgc agtggtccgt cgagccgccc gatgtggtgc acgggcactt ctggatgtcc
    11341 ggcctcgccg cgatgttggc cgtggtcggg accgagatcc ccgtcgtgca gacctttcat
    11401 gcgctcggcg cggtgaaacg gcgctatcag ggtgcggagg acaccagtcc cccggaacgc
    11461 atcccggtgg agaagctgct tgcccagcag gtggcgcaca tcatcgcgac ctgctcggac
    11521 gaggtgttgg agctggcgga cctgagcgtc gacgggtcgc gggcctccgt cgtgccctgc
    11581 ggcgtggacg tggaccgctt cagcccgatc gggccgcgcg cgcgcctcac cgaggcgcat
    11641 cggattgtca gcgtcggcag gttggtgccg cgcaaggggt tcgacatcgc cgtggcagcg
    11701 ttggccgagc tgcccaacac cgaactggtg ctcgcaggtg gtcccgatga cggccgactc
    11761 gacgaggacc ccgaggcagg ccgactccgt ggcctggcga cggaactcgg cgtgggagac
    11821 cgattgcgaa tgctcgggca ggtgccccga ggcgacatgc ccggcctgtt tcgctcggcc
    11881 gacgtcgtgg tgtgcacgcc gtggtacgag ccgttcggca tcaccccgtt ggaggcgatg
    11941 gcctgcggtg ttccggtggt ctcggcctcg gtcggcgggt tgatggacac cgtcgtcgac
    12001 ggggtcaccg gcaccctggt gaaaccccgc gaccccgccg agttggctgc cgcggtgtgg
    12061 gacctgctgg ccgatccgtc acgtcgacgg cgatacgggc tcgccggtcg gcagcgggtg
    12121 cgcgaaggct actgctggga tcgggtcgcc gaggagactc tgcgcgccta tcggctggtc
    12181 tgcgcgccct ctacggaagg catcggcggc ggccaggcgg tggtctgaac cctcggggcc
    12241 gaagtcggga gcaccctgac tcaacccaca tatcgccggg ccgaggaacg gcgttgctgc
    12301 gcctccaacc gcatcagccc cagttccacc gacaccggca ccacctgtcg ttcgcgcagc
    12361 acccacggaa gcccacgcag tgcctccaac acggctttca gcgtcgcacg gtcggccggg
    12421 gcggagcgca ggacgacgag acttcgacgc agcacgctgc gcagcgggcg gcgcaaccac
    12481 agcgtccaca gggtgttgcg gatgccgagc tggcgccgac gccgcgcatt gcgcacccgc
    12541 gagggcgcat ggtggatcac catgtcctcc acccaacaca tccaccagcc gcgcgccgcc
    12601 aggtccaggg ccagcagttc ctcctcgccg ccgagccaca tgcgcgacga gaacccgccc
    12661 acctgccgga aggccgagac gcggaacgcc gacaaaccag ccatcacccc gagcagggcc
    12721 gggcccggca gccacttcgg gccgcgcacc ggggacgccc gcagttccgg ggtcagcggg
    12781 tcctccgcca gctccggttc gaccaggcat ctcccggtga ccgaggccag gccgggatgc
    12841 cggtcgagca gggtgaccgc gcgggtcaac gcgcccggct gccatcgggt gtcgtcatcg
    12901 cagaacgcca cataaggggt gtcgattcgc cgcaccgcga cattgcgggc caacgagccg
    12961 agattgcggt cggcgcgaat caactcgacc tgcggatagg ccgccgcgac ggcatccgcg
    13021 gtgccatccg aggaggcgtt gtccaccagc acgatcggcg cggcatcggg cagcgcggtc
    13081 acctgcgcga gggtctccaa cagctgttcg cgccggtcac aggtgatgat cacgagggtg
    13141 atgcggtcgc cgcccatggc tgcctgctcc tctcctcggc acgttcgagc acccgcaccc
    13201 gccgctcgac ctcggcgggc aaccgatgcc gctgccacag cgccgagggc aaccgccgca
    13261 gcaggcctgc cacgatccgg gaacgctgtc gccgatcgcc ttcgcgcagc agcaggcggg
    13321 tctcggcggc aacgcggggc agcggccggc gcatccacgc gatcagcgtg ttgttccgac
    13381 gttccagatc tttgcgccac gccgaaggcg ggcggttcgt cgagggatgg tggtgcgcac
    13441 ggagttcggc cgcgtaacag agatcccagc cgtcggcggc caagtccaag gccagcagtc
    13501 gttcctcggc gccgaagtgc agtagccgac tgaacccatt gacccgcagg aacgccgtcc
    13561 ggcggacgat cgcggcacag gccaggaaac ccaacaccga cggccccggc agctcgctct
    13621 ggtggcccag cgggctcgtt gccaacaggg tgttgatcgg gtcctcggtg tcaccgggtc
    13681 cgaccagtgt tcgggcggcc aacaatccca cgctgggatg ggcgtccaac aggcgttcgg
    13741 cggcgggcag cgcatcggcc gcccaccagg agtcgtcgtc gctgaacgcg acgtacgggg
    13801 tcgtggcggc gaccacgccc agattccggg ccgccgcagc acggttggcg ggcagcctga
    13861 tcagtcgtac gcccgccacc tcggcgacag cggcggccgt cgcatcggtg gatgcgttgt
    13921 ccacgacgat gatcggcggg gtcggccgca gcgcgcgcag tcgggcgagc gtgtgtcgca
    13981 gctccccggc tcggttacgg gtggcgatga ccaccgtggt cctgggctcg ctcatgagaa
    14041 gcccgccgtc gccctcgggg cgcccccatc gcaccaggca accggccgac ctgcggggca
    14101 attcgacgac cacccgcaga acgccgtagc ccgtcgcatc ccggagaagg cagccatatc
    14161 cagccgcata ccccgcacgc cacctcgccg aacctcctgg gcgacatgga agtaccggcg
    14221 tgtggaccgc tatggggtcg ggtaatcgct ggtgtgactc gacgcatcga acgggccctg
    14281 gtgaccgggg gcatgggttt cgtcggttcc cacctgtgcg aactgttgtt ggccgagggc
    14341 agcgaggtgc tgatactcga caacctcgtc accgccgccc ccggcaccgt cgccgagttc
    14401 ggcaaccggc cgaacctgcg agtcgacagg caggacgtca ccgaaccgat caccacgccc
    14461 ggacccttcg acgtcgtgtt ccacctcgcc tcggccgcct caccgcagga ctatctgcgg
    14521 ctaccgatcg agaccctgcg ggcgggatca ctcggcacca cccacgccct cgacgtcgcc
    14581 ctgcgcgatg gcgcgcgctt cgtactcgcc tccaccagcg aggtctacgg cgaccccgca
    14641 gagcatccac agcgcgaaag ctattggggc cacgtcaatc cgatcggccc gcgcagcgtc
    14701 tacgacgagg ccaaacgcta tgccgaggcg ctgaccaacg cctatcgcgg tcatcgcggg
    14761 gccaacaccg ggatcgcccg catcttcaac acctacggcc cccgcatgcg ccccgacgac
    14821 ggccggatgg tgcccacctt catccgccag gccctggccg ggctgccgat gaccgtcaca
    14881 ggagacgggg cccagacccg gtcgctctgc tacgtcgccg acaccgcccg aggcctgttg
    14941 gcactgggca ggtccgacca tccaggcccg atcaaccttg gaaatccggt ggaactctcg
    15001 gtcggcgacc tggccgccga ggtgcggtcg gcggcgggca gtgaatcccc ggtgaccttc
    15061 gtcgaagcag ccgaggacga cccgcgccgc cgctgtccgg acatcaccct ggcccggcgg
    15121 cagctgagct ggcgacccga ggtcgcactg gccgacgggc tccgcagaac catcgactgg
    15181 ttcgaggaaa acaccggtat tcgcgctgct caccccgcat gaccgcgatc cgggcgggcc
    15241 gcaggaccgt ttaccggtga cccgatcggg caacgctgta gaggcacatc gcgactggtt
    15301 cgaccaccga ccacagcggc gccgacgaga ggggcgagac gatgcgcatc ctcggggtca
    15361 acgcggtctt ccacgatccc gctgccgcgc tcgtggtgga cggccacatc gtcgccgccg
    15421 cagaggaaga gcggttcagc cgtcggaaac acggcaagag cccggtgccg ttctccacct
    15481 gggaactgcc cgagcaggcg atcgcctggt gtctgcaccg cgcggggctg cgtcccgatc
    15541 agctggacgc cgtcggctat tcctacgatc ccgacctcgt cgaccactcc ctcggcggcc
    15601 tggaccccgg cagtgaggaa ctgcgcaccg actatgtccg gcgagcaccc gcctttctac
    15661 gcagcgcgat gcccgggctg gacccgtcga tcgtgcgctt cgtccgacac cacgtcgcac
    15721 acgccgcctc ggccgcgttg gccgcgccct tcggggattg cgcggtgttg gtcgcggacg
    15781 ggcgcggcga gagcacctcg tatgtggcgg gcgaatatcg tgacggcaag ttcaccgaac
    15841 acgccgcgca acagctcccg cattccctcg gcctgctgta cgaggacctc accgaacacc
    15901 tcggcttcgc ccgatccagc gacgagtaca agatcatggc cttggcctcg tacggaaagc
    15961 cacggtttct cgaccgcttc cgtgaactcg cctatcccac cggagacggc ggcttccaca
    16021 ccgatcccgt gtcctggacg gaattcgccc ccgcccggca cggctcggac accgaactcg
    16081 actccgcgca cgccgacctg gcggccagcg tgcagcgccg catcgaggag gtgtggctcg
    16141 atctggcgac ctggctgcac gaccggaccg gcgcgaagaa cctcgcgttg gcgggcggca
    16201 tcgcgttgaa ctgtgtcgcc aacacccgcc tgtacgccga gggccccttc gaccaggtgt
    16261 gggtgcaacc cgcctccggc gacgcgggaa ccgcgctggg cgcggccttg cagctctcgg
    16321 ccgatctcgg cgagcccacc ggccccatgc ccggcgccga tctgggccgg gagtggtcgg
    16381 acgacgagat cgaggagatc ctgcgggtcg cacgggtccg ctacgaacgg ccggcggacg
    16441 tcgccgtcga ggtcgcgcag gccttggcgg acgatcaggt ggtggcctgg ttccagggcc
    16501 gcgccgaatt cgggccgcgc gccctcggac accgctcgct gctcgcccac cccgggccga
    16561 ccgcgaacct cgggcggctc aacgatgtga aggggcgcga gcagttccga cccgtcgccc
    16621 cgatggtcct cgccgaccgg gccgccgaga tcttcacccg aggaccgctg cccagcccgt
    16681 acatgctgtt cgtgcacgat gtcgcggccg actggcgaga ccgcatcccc acggtgaccc
    16741 atgtcgacgg cacggcccgc gtacagacgg tcgccccgca gcacaccccg ctgttggcca
    16801 ggatgctccg ggagttcgag gcccggaccg ggctgccggt ggtggtcaac accagtctca
    16861 acacggcagg caggccgatg gtcgactcgc cgagggacgc gttggagtgt ttcggctcgg
    16921 cgccggtcga cctgctggcc atcggaccgt tcgtggtgcg tcgatcatga tcgactacag
    16981 catcgtgatc cccacgaccg gccgggacaa cctgtggcgg ctgctcaccg cgttgcggaa
    17041 agccgacggg ccgccgccgc gcgagatcat cgtggtcgac gaccgagccg aggccttcga
    17101 agacctcgcg ctgcccgcgt cggcagccca gatcaccctg ctgcgctccg gcggacgcgg
    17161 ccccgccgcc gcccgcaacg tgggctggcg acaggccacc gccgagtgga tcgccttcct
    17221 cgacgacgac gtcatcaccg acgcccggtg gcccgcccgg ctggcggccg acctgaccgg
    17281 tctggacgca acggtcggcg cctcgcaggc gcgcatcgag gtcccgctgc cggacgatcg
    17341 acgccccacc gacgacgaac gcggcaccgc cggactggca ggcgcccgct ggatcaccgc
    17401 cgacatggcc taccggcgaa ccgcgttggc cgtggtcggc ggcttcgacg aacgcttcac
    17461 ccgcgcctac cgggaggacg ccgacctcgc gctgcgcgtg atcgaggacg gctacgccat
    17521 cgtctccggg catcgcgtca ccacgcatcc ggcccgccga tcgggcgtgc tggccagtgt
    17581 tcgggcgcag cgcggcaacg ccgatgacgt gctgatgcgc cgcaaacacg gcgtccgctg
    17641 gcgctcccgc atcggcgagg gacacggccg actgggctgg cacgcggtca ccaccgccgc
    17701 cggtgcggcg gcaggcatcc tgttcgccct cggccatcga cgggccgcag cggcctgcgg
    17761 cgcgggatgg gcggccctga ccggtcggtt cgccgccagc cgcatcgcac ccggcccccg
    17821 caccgccgac gagatcggcc ggatgctgct gaccagcgtc ctcatcccac cggtcgcctg
    17881 ctggcaacgc ctacgcggcg aactccgcta ccgaacccga cggcacaggg gcgacccgcc
    17941 gccactggcg ctgctgttcg accgggacga cacgctgatc gtcaacgtcc cctaccttgc
    18001 cgaccccgag gcggtgcgcc cgatgcccgg agctcgggac gccctgcact ggttgcgccg
    18061 cgaaggcatc cgcatcggcg tggtcagcaa ccaatccggc gtcgcgcgcg gcctgatcag
    18121 ccagacacag ctcgcggcgg tcaacgcccg cgtcgaggaa ctgctcggcc cgatcgagac
    18181 ctggcagatc tgcgtgcacg acacggcgga acactgtgtc tgccggaaac cggcgcccgg
    18241 catggtcgaa caggccgcca gggccctcgg cgtcgacgtc gcccgctgcg tcgtgatcgg
    18301 cgacaccggg gccgacgtcg cggcggcacg agccgcaggg gcccgcgcga tcctggtgcc
    18361 cacggccgcc acccgacaga acgagatcga cgacgcacac cgccacgcgc gggtcgcccg
    18421 ggatctcgcc gaggccgtgg cactggccct ggcaggtgtc cgatgacgca gcgagtactc
    18481 atcgcgcgcc tggacagcct cggagacgtc ctgctggccg ggccctgcat tcgagccgtc
    18541 gccgcaggcg ccgactccgt cacgctgttg gcgggcccgc tcggcgcggc ggcaggcccg
    18601 ctgctgcccg acctcgacga ggtcctgatc tggcgggcgc cctggatcga cccgcaaccc
    18661 gaaccggtcg gccccgcagc ggtggccgaa ctcgtcgaac gaatccgggc gggtcgcttc
    18721 gaccgcgccc tggtgttgac ctccttccac cagtccccgc tgccgttggc gctgctgctc
    18781 cggctggccg gggtgccgtg gatcggggcg atctgcgagg actatccggg atcgctgctg
    18841 gatctgcgcc acagcgtcga cggtgatccg ccggagagcg aacgagccct ctcgctggcc
    18901 gaggcggcgg gcttcccgct acccgccggg gatcgcgggg cactcgccgt gcggcggcca
    18961 ctgcccgagg tcgccgcgct gaccggcccg cccggctatg tggtggtgca tccgagtgcc
    19021 tcggtgcccg cccgacagcc atcggccgcg cgatccgccg cgatcgtcga ggcactgctc
    19081 gccgccggac atcgagtcgt ggtcaccggc ggcaccgccg accgcgcact gaccgccgag
    19141 gtcgcgacgg accgagctct cgacctcggc ggcaccacca cgctcgcgca gctggcctcg
    19201 gtgctcgacc gggccagtgc ggtggtggtg cccaacaccg gacccgcaca cctcgccgcc
    19261 gccgtcggca ccccggtgat ctccctgttc gcgccggtcg tccccgcgca gcggtgggcg
    19321 ccacacggcg tgcccaccgt cctgctcggc gaccaatccg ccccctgccg gggaacccgg
    19381 gtccgggaat gccccatcgt cggacatccc tgcctggagt ccattcagcc tgacgaggtg
    19441 gtcaccgcgg tcgcacgact cgcggagccc accacaggtg cgccgcagtg ccgcctgacg
    19501 acgggaggtg tctcgtgatc gaggagcatt tcgcggcact gtgcgaagca ttgcggcgga
    19561 ccgactcggc ggcgcccgta ctacggcagt gggccgccca gctggcccgg atcctgcccg
    19621 ccggggcccg actactggcc tgcggcaacg gtggcagcgc cgccgaggca caacacctga
    19681 ccggcgaact cgtcggccgc ttccgcgacg aacgccaacc cctctcggcg atcgcgctgc
    19741 acgccgacac ctcggcggga acggcgatca tcaacgacta cggcggaagc gagctgtacg
    19801 cccgccaggt ccgggcccac ggcaggcgcg gcgacgtgct ggtcgcactg tccaccagcg
    19861 gttcaagcga gaacgtggtc gccgcggcga aatcggcaca cgacatcggc gtcaccacct
    19921 gggcgttgac cggcccggca cccaatccgc tggccgccct ctgcgatgac gccatcaccg
    19981 tcgatgcacc cgacgtcgcc accgtgcaag aggtgcatct cgccctcgtc cacgcactct
    20041 gcgcggcact cgacggggaa ttgggggtga cgacgtgaaa ccgctggtcg tactcggtga
    20101 cgcactactc gacgtcgaca tcgagggcac cgtggagcga ttctgccccg gcacccccgc
    20161 agcggtggtc gacgtcggcg gggagctgcg tcgacccggc ggggcgggtc tggcggcatt
    20221 gctggcatcc cgatcgaccg ccgaggtcgt gctggtcacg gcgatcggcg acgacgacgc
    20281 gggacgaacc ctcatcggcc tgctggatcc ggtggtcgag gtgctcccac tgcccctaca
    20341 gggcgagacc gtgcgcaagg cacgggtgcg tgtcggaaac caatcgctgc tgcgactgga
    20401 caccggcgat ggcatggcct ccacggcacc cgtggcccaa cgggtgcaga gcgtgctgcg
    20461 cggagcgggc gcgatcgtgg tcgccgacta cggccgagga gtcgccgcgc accccgacat
    20521 ccgacggctg ctcgccgaac tcgccgcgac cgtgcccatc gtctgggacc cgcatccccg
    20581 tggccccgcg cccaccccgg gcgcctggct catctcgccg aacctcgagg aggcacgccg
    20641 cttcgccccg gcctgcgggc aggacaccga actggccagt gtgctgtgcg ccgaatgggc
    20701 ggcgggcgcc gtggtggtga ccaccggggc cgacggcggc atgctcgccc acggcgggcg
    20761 aaccacgacg gtgtcggtgc cggaggacgc gcggctgttg gcctcggtgg aggcggacgc
    20821 ctgcggcgcg ggggactgtt tcgccgccgc cgtcgccgcc ggcctgatcc tcggccagga
    20881 cgtcgccgcc gccgtggccg gagccgtcga gaccgccgcc cggttcatcg gagcaggcgg
    20941 cgcgggagcc ctgtccatca gcgtggagcc gaggttgacg gccgccgcat cgcggaaact
    21001 ggattccgcc ttcgaaatcg cggcccgcat ccgcgccacc ggcggcagac tcgtcgccac
    21061 cggcggctgc ttcgacctgc tccatcccgg ccatgtgagc ctgctccggc aatcccgagc
    21121 actgggcgat gccctggtgg tctgcctgaa ctccgacgag tcggtgcggt tgctcaaggg
    21181 cgagggacgt ccgatcgttc ccgcgcaaga ccgcgcacgg ctactcaccg agctgtcctc
    21241 ggtggacgcg gtcgccgtgt tcgacgaacc gtcgcccgcc gccctgctgg agcggctctg
    21301 ccccgatgtg tgggtcaagg gcggcgacta cgccaacgcc gagctacccg agagccgggt
    21361 cgtgcacggc tacggcggcg agaccgtgct gatcccgacg gtcgcgggct actcgacctc
    21421 ccggttggtg gccgcagcac atgcgaggag ctgaaacccg acggagacag gagcatccca
    21481 tgtccaccct cggcaatatc gtgatcaccg gcggcgcgtc cggactcggc gcggcaaccg
    21541 tcgaggtcgt gcgggagaac ggcggcacgc ccctggtcat cgaccgtgcc aaacccaaat
    21601 ccgacgtcga gttcgtcgaa gccgacctgt ccgacaccgc ctcggccgaa gccgccgtca
    21661 acgaactggc ccgccgcgca ggcggccgca tcgacggcgt cttcaccgca gcgggcaccg
    21721 acgcgtgtgg cacgctcgac gaggtctcgg tcgcggactg ggaacgcgtc gtgcacgtca
    21781 acctgctcgg caccgtcgcc gtcgtccgcg ccgccctgcc ctttctcaaa cagagcaagg
    21841 gaaccgtggt gacctgcgga tccaccctgg gcatcaaggc cgtttccgat gcgaccgcct
    21901 actgcgccgc gaagttcggc gtcgtcggct tcaccagagc gctggccacg gagaccgcag
    21961 gccagatcgg ggtgaccctg ctgattccgg gcggcatgca caccgcgttc ttcgacaacc
    22021 gcaccgagca gtacaaaccg ccgccggacg cgaagctgaa ccagccggag gacgtcgccc
    22081 gcaccgtggc cttcgtcctc agccagccgc cgggatgcga gatcagggaa ctcgtcgtct
    22141 gctcgtcgga agagtcctcg tggccgtgag cgactccgtt ctggtgttgc gggcgctggg
    22201 catcggggac ctgctgaccg ggattcccgc gctgcgcgcg ctgcgccgcc accatcccga
    22261 cgcccgcctc gtgctggcgg cgccggagaa cctgcgtgcc ctcgtcgacc tcatcgacgc
    22321 ggtggacgaa ctgttgccga ccgccggact cggcgccctg cactggtcgg aggccccgcc
    22381 tgcggtggcg gtgaacctgc acggccaggg tccgcagagc attcgcgatc tacgcaaggt
    22441 gcgtcccggc accctgctca cccatcgcca ccccgactat cggggggtgc ccggcctgga
    22501 atggcgggac gacgtccacg aggtcgaccg ctggtgcaga ctgctggatt tcggcgggat
    22561 ggatgccgat cgcgccgacc tccacctgcc gcgaccggcc ggttcgagcc cccggccggg
    22621 agccgtcgtc atccatcccg gcgcggcgta tccggcccgc cgctggccgc cggatcgcta
    22681 tgtcgaggtg gcccgcgccc tgcgatccga gggacacgag gtcgtcatca ccgggagccc
    22741 ggccgaacag gactcggcca cggacatcgc ccgcgccgcc ggactaccgg attcggcggt
    22801 actggccgga cggaccgacc tcgccggact cgccaggctc gtcgccgacg ccacgctggt
    22861 catctgcggc gacaccggag tcggccacct cgccaccgcc ttcagcacgc cctcggtgtt
    22921 gctgttcggc ccgacgccgc cgaagctgtg gggcccgccg gccaccgccg agcagcacat
    22981 cgccctgtgg gtgggcgacg tcggcgaccc gcacgcggac cggccgcatt cggggctgct
    23041 catgctgctg ccgaaccggg tcctggccgc cgcacacgag ctgctgcccg accgggtgca
    23101 ccatggttag ccatctcggc gtggtcggcg cagggtatgt gggactcacc agtgccgcat
    23161 gcctggccca cctcggtttc cgagtgacct gtgtggacaa cgacgtcgcc aaggtcgacc
    23221 gactgtgcgc gggcgaggtc acgatcgccg agccgggact ggccgatctc gtggtggccg
    23281 gacggacccg gagccgtctc gatttcacca ccgacatcac cacgctcgcc ggcgtcgacc
    23341 tggttctgct gtgtctaccc accccgatgg gcccggacgg cgcctgcaat ctggacgtct
    23401 tcgaatcgac cctggcgatc ctcggcggcg tactgcgccc cggctgcgtg atcgtcacca
    23461 agtccaccgt gccgctgggc accgcaggcc gggtgccccg gttgctcggc cgcgcggatc
    23521 tgccggtggt gagcaatccc gagttcctgc gcgaggggca cgcggtcgag gacttcctgc
    23581 atcccgaccg ggtcgtgatc ggcgccgacg ccgcgtatcg ggacgccgcc gaggaggtcg
    23641 ccgcgttgta tgccgaaacc ggggcccccg tgctgcacac cgaccccgcg accgccgagg
    23701 tgaccaagta cgccagcaac gccttcctcg cgatcaaggc gtcctatgtc aacgtgctcg
    23761 ccgagctgtg cgaacgcgtc ggcgccgacg tcaccgaggt cacccatgcc atgggcctcg
    23821 acgatcggat cgcaccggat ttcctcaccg ccgggccggg ttggggcggg tcctgcctgc
    23881 ccaaggacac cagcgcgctg ctgcgggccg ccgaggaggc aggcgtggac ttcgcgctgg
    23941 tgcgcgatgc ggtgaaggcc aatgcgcggc agcaggcgac ggtggtgcgc aaggtgcgct
    24001 gcgcggtcac cggctcggcc gacggttcac tggtcggggc gcggatcggc atcctcggcc
    24061 tggccttcaa agcgggcacg ggggacctcc gcgactcccc tgcaatcgcg atcgtcgagg
    24121 cgttggcccg ccagggtgcg atcctcaccg cctacgaccc ggcggtgggg gcggctgtcg
    24181 gtctcggcat ccacggggtc ggcgtggtct cggacccgta cctcgtcgcg gaggatgcgg
    24241 cagcgttggt cgtgctcacc gaatggcccg agttccgcac cctggattgg acggcgctgg
    24301 ccagggcggt gcggcatccg gtggtggtcg acatgcgcaa cgtgctcgat gcggccgagc
    24361 tggcgacggc ggggttccgg cgggtcgggt tggggacgag tgctgagccg atggcttgac
    24421 gggcggaacg gttgcggggg ctcggttgac gggcgcctgc tgcctgcgga ctcgggaaat
    24481 tcggttgctc cgattggagc aatctgcgaa cgtctgcgcc cgtatggggt cggtgggcgc
    24541 aggttgggga ggatcagcgt gagcggggtt cgagagcctg atcgattggg atcgcatacc
    24601 ttgcgcgatg gccgtcggct ggcatgggcc gagtggggtc cgagcgatgg tggtcccgtg
    24661 ctgttgtgtc ccggcgcggc gaccgggcgt tccctcggat tcggcggcga cgacgtcgac
    24721 accctgggcg tgcggctggt atcgctggac cggcccggtc tcggcgcctc cgatcccgcg
    24781 ccaggtagga ctctgaccga ttgggcctcg gatgtttccg aggtgatcga ggcattggag
    24841 ctgaccacgg cttccggcgg taggccttcg atggtgggct tctcccaggg tgcgcccttc
    24901 gcgttggcct gcgcggcagc gggactcgtc tcggccgtcg cactggtctc ccccaccgac
    24961 gaactcgccg cgcccgcgat cgtcgaactg ctcccgccgc aggtccgtga cctgatcacc
    25021 atggcgacca ccgacccggc tgcggccgag gcctccttcg ccggtttcgc cgatgcgacg
    25081 tcgatgcgcg agatggtgac tcagatgagc ggtccggtgg accgcgccgt ctacaccgcc
    25141 cccgaattcg acgccgccta ccgccgggcg ctggccgagg gcttcgccca aggcccggcg
    25201 ggatacgccc gcgacaccct gctctccatg tcccgctggc cattcgaccc ggccgagatc
    25261 accgtccccg tgacgctctg gttcggcgcc cacgacacca accccaccca ctcccccgac
    25321 ctcggccgca ccctcgccga gcgactgccc aacgcccagc gcagcgaact acccgacgag
    25381 ggcggatcgc tgctgtggaa gcgagcgggg gagattctgc ggggagtggt cggagcgggg
    25441 tagggcgtcg gcgagatatc ccctcgtcca gctgcatggt taccggccag agcacggcac
    25501 caccggcacg ccgtggagca tgtggccaag aaccccaggg ttccccgcac gccacgaacc
    25561 cgtgctcggg gacctgagcg caacacgccg agacagacgt catcacaggt cagcgcaccc
    25621 tttgaggaaa atgccgggcc cttatgcgga ggctcgacgt cgtaagacag gatgaaccgt
    25681 tagccccgcg cacgcgggga ggaatcggtg cccgccccca gccgtctaca cgtctgcccc
    25741 cgcgcacgcg gggacccctc ggccgacctc tcttcccgca cgcgcggcgg tacagcctcg
    25801 cccgttcctc gccgccaggg agagttgtgt ccgactcgtt cgtccatcta cacgtccaca
    25861 ccgagtactc gatgctggac ggagccgcca aggtagcgcc gctgttcgcc gaggccgagc
    25921 ggctgggtat gcccgccgtc ggtatgaccg accacggcaa catgtacgga tcggccgagt
    25981 tttaccggca ggcgaagaag cgggacatca agccgatcat cggtatcgag gcctacatcg
    26041 ccccggtgag ccgctttcac aaaaagccgg tgttctgggg tgagagcaac cagcgctcca
    26101 gcgaccaatc cggtgagggc ggcgacgtct ccggcgcggg cgcctacaca cacatgacga
    26161 tgctcgcggg caacgccacc gggctgcgca acctgttcaa gctttcgagt ctggcttctt
    26221 acgagggcta ctaccgcaag ccccgaatgg accgggaact catctcagag cacgccgagg
    26281 ggatcatcgc caccaccggc tgtccctccg gcgaggtgca gacccggctg cggctgggcc
    26341 agccgcgcga ggcgatgcag gcggcgtcgg actatcggga catcttcggc gccgagaact
    26401 tctttctgga gttgatggac cacgggctgc ccatcgagcg atcggtgcgc gagggcctgt
    26461 tgcacatcgg tcgcgaactc ggactgaagc cgttggcaac caacgactcg cactatgtca
    26521 cgcaagatca agccgatacc cacggcgcgt tgctctgcgt ccagtcgggt aaaaccctca
    26581 ccgacccgac ccgcttcaag ttcgacggcg acggctacta cctgaagtcc gccgatgaga
    26641 tgcgggccta ctgggacacc gaggtacccg gcgccacgga tagcacgctg ctcatcgccg
    26701 agcgtgtcga gtcctacgac gaggtctacg cccatgtcga ccgaatgccc cggttcccgc
    26761 tcgctgaggg agagacggag aacagcgttc tacgggccga ggtcgaacag ttcacgccag
    26821 cccgctttcc gaacggattg acccaggagt accaggaccg catcgagcgg gaactcggcg
    26881 tcatcgccca gatgggattc ccggcctact tcctggtggt cggcgacctt gtccggtggg
    26941 ccaaggacca gaagatcgcc gtgggtccgg gccggggttc tgccaccgga tcgctcgtgg
    27001 cctacatcct gcggatcacc gacctcgacc cgatcgagca ctctctactg ttcgaacggt
    27061 tcctgaaccc cgagcgcatc tcgatgcccg acatcgacct cgacttcgac gagcgcaggc
    27121 gcggcgaggt catggactac acggtcgaga aatggggcgc ggagaacgtc gcacaggtca
    27181 tcacctacgg caccatcaag accaaggccg ccatcaagga tgccgcccgc gtccactacg
    27241 gccagcccgg attcagcatc gccgaccgga tctccaaggc gctccccccg ccggtagcag
    27301 ccaaggacat cccgctggca ggcattgtcg accccagtca cgagcgatat gcggaagcca
    27361 gtgagatccg ttctctgatc cagagcgatc aggaggtctc gaccattttc gagaccgccc
    27421 gaggtttgga gggtctcacc cgtaacgcgg gcgtgcacgc ctgtgcggtg atcctctcct
    27481 cgcagccgct gctcgacgtc atcccgctgt ggaagcgcga tgacgggtcg atcatcaccg
    27541 gctgggatta cccggcttgc gaggacatcg gcctgttgaa gatggacttc ctcgggctgc
    27601 gcaccctgac ggtcatcgac gacacgatca aggaagtcga acgcaaccac gggatccaga
    27661 tcgacctcga gaccctggga ctcgacgaca aggcgtccta tgagctgctg agtcggggcg
    27721 acaccctggg cgtgttccag ctcgacggtg ccgcgatgcg ggacctgctg cgccgtatgc
    27781 aacccaaaca cttcggtgac attgccgctg tgatcgccct gtaccgaccc ggtccgatgg
    27841 ccgcgaacgc gcacatcaac tacgccgagc gctcgaacgg caggcagaag atcacgccca
    27901 tccacccgga gctgaaggac gctctggagc cgattctggg tgagacctac cacctgttgg
    27961 tctaccaaga gcaggtcatg gccatcgccc agcagctcgc cggatacacc ctgggtggcg
    28021 cggacctgct gcgacgggcc atgggtaaga agaagaaaga ggtcttggag caggagttcg
    28081 agaagttcaa caaggggatg ctcggcaacg gctactcgga ggagtcgatc cagacgctct
    28141 gggacgtcat gttgcccttc gcgggctatg cgttcaacaa gtcccatacc gccggttacg
    28201 ggctcgtggc gtactggacc gctttcctca aagccaacta cccgactgag ttcatggcag
    28261 ctcaactcac gtccatcggc ggcgacaagg acaagtccgc cgtgtacctg gcggagtgca
    28321 ggcgcttggg catcaaggtc ctcgcaccgg atgtgaacga ctccgggttg cacttcgccg
    28381 ccgtcggcaa ggacatccgc ttcggcttgg gcgcggtacg gaacgtgggc gccaacgtcg
    28441 tgcaatcgat cgtctctcgc cgcaaggaaa agggccgata cacctcgttc accgatttcc
    28501 tggataaggc cgagatcgtg gcctgtaaca agcgggttat cgaatcactg gtcaaggcag
    28561 gtgccttcga ctccttcgat acctcgcgtc gctccctttt cgaacatcac gaggcggcgg
    28621 tcgatgccgt gatcgggctc aagcgccagg aggcgctcgg ccagttcgac ctgttcggtg
    28681 gcggagacga ggacggcggt gcgtccgccg aggcctcgcc gttggcccac ctcaacttct
    28741 cctcggacga atggccgcgt aagcagctac tcgcctacga acgggagatg ttgggcctct
    28801 acgtgtcggc gcatcccttg gacggtgcgg aacgcatcct gcgcaagcac gcgccgaagg
    28861 cgatcgcgac cattgtgaac gaggcgccga aggagggtga ggtcgtcgtc gccgggatga
    28921 tctccagcgt cgatcgccgg gtgaacaagc agggcgagcc gtgggcgatc gtcaccatcg
    28981 aggacctgga ttccgcaatc gaggtgctgt tcttccacaa gagttacagc gtcctgcacg
    29041 aggatctgat ccccgactcc tcggtcgcgg tcaagggccg ggtgaactgg cgcgaggaca
    29101 agatgtcgat cttcggctcg ggtgtggtcc agctcgacat cagcgcggcc gagaccaatc
    29161 ccggggtggc acctgccgtg atgttgcggg ccgaggccca ccgactgacc cgcgacgtcg
    29221 tcggcgaact gcgcagcacc ctgctggccc accggggcga tgccccgttg cggttggtcc
    29281 tggtgcacaa cgacgccgag gagacctacg aggtcgagaa gtacccggtc gagttcagcg
    29341 gcgccttcgc cgccgagctg aaggcgatcc ccggtctgac ggtggtgtcg tgagccgctc
    29401 tccgggaagc tcaggcaccg agcagactgc gtaggcctcg ctccaccgcg aggaaatcgt
    29461 acaacgaggt atcgatcacc gcctcgatct cggcttcgtc gacggcggcg cgcatcgcgt
    29521 cgccgtcgac gagacccaag tccaccaata ccgactcctc gatcacctgc ttcgctaacg
    29581 acagtccacc gagacgtaat ccacgctgca tcacacccgc gaagttctcc cgcagcgccg
    29641 gatagaccac gtcattactc aggccgagtc gctcgagcca gacccgcgcc aaccgcttcg
    29701 aaacccgcca atccataggc aaccattgcc cgaacaagac cagctccgga tcgcacaacg
    29761 gggagaccgg ccacctaccg gcgcggagaa agatcgggtt gcggcaggcg aaggccaaca
    29821 aggatgtctc gtgaaggacg ctgaccggcg ctagatcctc gtcgatcgac ggaagctgtt
    29881 ctcgtgctcg gtgtcctagc cagcgtggtg gtttctgcgc acaccggcgg ccgaaatcgg
    29941 accgttcggc actccgtaac gcaagcatct cgtcgccgcc gatgccggtg aacacaacgg
    30001 gctccgacga cgtcatgaga atccgatgta gggcctcggc atagggctct tcgcctgggt
    30061 tcgcagccct gggaccagct ggatcgaatg gccggcacgc cgggatcgac acatcacgca
    30121 atgagcgaaa ccggacgagt tcagcgcgtc gacggcgttg ctgggctgct gcttctccct
    30181 cgatactcag gccatagctt gctagaccag gacttcccgc agccaaggtc aacgcgacca
    30241 aagccgagtc cagtccgccc gagagttccg cgaccgcact ctcgctggtc acttcacggc
    30301 ggcgcaccgc ctgaccgagc agtgagtcga acgcatcgag aaccggagcg tcaggaccga
    30361 cactccgtgc ccgatatcga ggagcagctt gcggatagca ggattccagg ctgcccgctc
    30421 gaaactcgac agaagatcgt tctgtgagtt gaacgaccga tcgggctatg gtgttccggg
    30481 tgtagcggtg ccgccgtgtc aagagtcgac tgagttcgcg gaaatcaagt tcggacgaga
    30541 caatatgtgg ccgcagatcg tcgaaatccc atgatgcatg caggcggctg tcgcgagcag
    30601 ccagatacag cggagcggtg ccccacgctc cggcatgcaa ccgaatagca ggccattcga
    30661 attcgaccac gacgaactcg accgaggtac gccgcagttg gtcgagagcg ttcacccagt
    30721 tttcaggctt gatgcggctg atcggtcctt gccatggcgc cgtatccggc attcgctccc
    30781 gaactatcac ggctgttcgg accccatccg tcacgagcag cgattcgagg gctgggttac
    30841 tgagcggctc tatccagcca catcgagccg tccatcgtcc ggacgaccac gaccagagcg
    30901 gccgatcggg cacgatcgcc agctgaagct tgagcacaca acctccaggt tcgggggcga
    30961 gccggtactg ccgactcacc cccggtccgt caatcctcgt ccttgtaccc ctggtcttcg
    31021 cttccagcag gcttgcgcag gtaacgctcg actgcctcaa cggtctcgat gataggcgga
    31081 ctgtcgaaga ggtcttccat ctcggccatg tggtttcacc tccattctgg ttgaatcacg
    31141 gataagttgc gtgtggtcac aactcatcga cgcacagggt gcccatcgtc gataggtcgg
    31201 agaacaagcc taagtaatcg agatccagcc atgcactcca tgatcaccgt tggatacggg
    31261 agtttcgacg cccattgggt ctagccccat cggggcttct ccgagcgtcc aaccttcgag
    31321 aacgggattt gctcgtacag tgcggacgtt gggcggccac agccgatacg gtatgaattc
    31381 ccgcgtctcg actaagcaac ggcggtagac cgtgagcagc cgacgaaagc actgccagtt
    31441 ctgtggagca tcgacacaca ccagtacggc gtgcagcacg tacgtggccg agttgagcgt
    31501 gtgcaagccg attcccccgg ggttcttcga tgatccgggt atgcgcacag cgctggccca
    31561 ctacgacttc ggggctgtgt tcctcgccgt gcggagccac accgggatgt cgcaactgga
    31621 actcgccgat ttgctcggac tctctcagtc tcgagtttcc gccgtcgagc gtggtgaacg
    31681 cagactcacg catgtgaagc tggctgcccg gatggccact gccctgcgta tcccagctca
    31741 gcgtttcgga ttcccaagcc gacccgatga actcgataat gctcatgtca aggaggcgag
    31801 ttggttggaa cgccgagact tcctcaacct ggtcacagcg gccgcgctcg gatcaaacct
    31861 gcatccggag atctcgcggc ttggcgaact gctcccttgg agtaccgaac cggttccccg
    31921 atcacgcatc ggggcagccg atgtcgatgc gatcgaagcc atgaccgacg gtttccgtcg
    31981 cctcgacctc gcccatggcg gtgggttctg tcgagcagca gcgatcgccc aacttcagca
    32041 ggttcgacga ctgagagatg ccatctgctc ccctgcggtt cagacacgcc tcgtcgtagc
    32101 cacggcggaa ctcgcctcga cggcaggttg gatggcctac gacgtcgatg atcacaacac
    32161 ggcgcgtcgt ttgtgggcct ttgcgcttgc cgaagctcag cacagcgcga accaccctcg
    32221 ggctgcggac cttgctgtcg ggcttctgct cgacatggcg catcaagccc tgcatctcca
    32281 acgcccagac gaggcccttc ggttgacgca gctcgcttcg gcgacggcct cgaatcgaca
    32341 gtttccggtc aacgtgatca ccgagggata catatcaacc gtgctcgggt ggtgccgggc
    32401 ttcactggac gagccgcagg ccgcagttcg cgcgatcagc caatcacagg agctatacgg
    32461 gcgcaccgaa cccggcgcgg tgccgccgtg ggcctcgttc gtcacggacg cagagatcac
    32521 tgcgcagcag ggccacgccc tttatctact ctcgttgaac cgccccgagt tcgcggccga
    32581 agccgcagat cagctgacct tcgccgtgga cgagtacagc gccgaccacg aacgaagtcg
    32641 tgccatggtg ctggcaccgt tggcatgcac acattttcgg aacggcgatc tgacggcggc
    32701 agtcgccacc ggtcatcagg cagtgagcgc aatcgctgag ctctcctcga cccgtggccg
    32761 tgctcgccta cgagtactcg atgccgtagc cgcccctttc gcccccgccc cggagatcat
    32821 cgaactacgg caacggattc actcgttcct tcattctgcg gcttagcaga cacgtctggc
    32881 cgcacataac tccccggtcc gacgtaccca cccctcactc caggtgggcc agggacgtga
    32941 tgacgcgttc ggcgatgtcc tggggccagg ggaaggcgac ggtcaccgcg cgttggtggg
    33001 cgaggccgtg cagtcccaac cacagcgcga cggtgtcgac ggccaggtcg ttgctcgtgg
    33061 aatagcctgc ggcgacgcat tcgccgagca ccgtgccgag taggcccatg cattcgtcgc
    33121 cgagggcggc catgtcgtcg gcggtcacgg aggtctcgct cagggcgggc atccatacgc
    33181 cgccgaacat gacgcggtag cggccgggcc gctgctgggc gtaatccagg tagcaatcgc
    33241 agacggcgaa caggcggcgg cgggggtcgt cgcctgcttc ggccgccgcg acgtgcagtt
    33301 tcgcggcgag ttcggcgaag atctgttgga ccacggcgag catgatgttc ggctgatcgg
    33361 ggaagtgtcg gtagatcgac ggggcggcga tcccggcgcg gcgggcgacc gagcgcaggg
    33421 tgatggcact ttcatcgccg gtctcgtcga gcagttccgt ggctgcggcg acgatctcgt
    33481 cgcgcagtcg gcccccctca cctcgacggt tgcgggtccg cgtcggagtc gtgcccgagt
    33541 catcagccat cccctgaggt tacacctgaa agcttatagc cgttagctct tgcggtacgt
    33601 gaccttacgg tcgtagcctt acgcctgtaa gcattcgagt ccgacccagg agcgtccgtc
    33661 atgaccagca ccgcgcttac ccgcaccacc gagatcgtgt tgcccggtga agtcgagccg
    33721 accggactgc aggtcaccga acgcgatctg cccgcacccg ccgccggtca ggtcgccctg
    33781 cggatggagg cgaccggggt gtcgttcgcc gagcagcaga tgcgacgcgg caagtactac
    33841 gaccagccgc cgtatccctt cgtcctcggc tacgacgtcg tcggcacggt gacggccgtc
    33901 ggagcgcggg gcgacgccgc gatggtcggc caccgatacg ccgccgtcac caagatcggc
    33961 ggttgggcca gccatctgct gctcgacgcc gccgatctgg tcgcggtacc ggacgaggtg
    34021 ggctcggccg ccgccgaggc cgtcgcggtc aacggggtca cggcgtggca gatgttgcat
    34081 cgcaccgcca aggtcgccga aggcggcgcg atcgtggtgc tcggcgccaa cggcggtgtc
    34141 ggttcactgc tcgtgcagtt ggcccggcag gcgggaatca cggtgatcgg gacggcgtcg
    34201 acacggcatc acgacctgct gcgcgagctg ggtgcgacgc ccgtggacta tcgggaaccg
    34261 gacatgtacc agcggattcg ggcgctcgcc cccgaaggcg tggacgccgt gttcgaccac
    34321 gtcggcggac ccggcctcac cgaatcatgg aagctggtgc gcaggggcgg gacgctggtc
    34381 tcctacggca cggcggcgac caaggacgtc gccggcaatt cgcagctccc ggtgttgcag
    34441 tccttcgccc ggctggggat gtggaacgcg ctgcccaacg gcaagaacgc ctacttctac
    34501 aacttctggg cgggtaggcg ggacctggat accttccgag ctcggctgcg cggcgacctc
    34561 accacggtgc tccggctggt ggccgagggg gtgctcaccc cgcagatcgc cgcggagttc
    34621 cccttgaacc aggccgcgtc cgcgctgcag ctggccgagt cgcgcaccgt cgcgggcaag
    34681 gtcgtcatcg tcgcgtagcc gacccccgaa ggcagtcggt acggcggcgc gatgcagacg
    34741 cgagcaaaga tcaggacact tgatcttgcg gactggtgga ctcaccacgt tcgcagccga
    34801 tgatgctcga attccgaacc cggagcccaa cacatgcgaa tgctcttcag tgccgtctcc
    34861 gcctacgggc acatcctgcc gttggcgccg ctgatgcagg cggctgtcga tgcaggtcac
    34921 gacgttgccc tcttaaccag cgagggcgtc cggccgctgg cggcgaacga actggccgcc
    34981 gaggtcgaac tcctgggggt ctgcgccgaa gcggaggacc atatcgccga ggcggcccgc
    35041 cggtccggcg gcgatccctt ccacccgacc cccgaggtga tcggcgaggt cttcggtaac
    35101 acccgcctga tcctcgacgc ggagaacggc ctctcggcgg cctcgacgtg ggcaccggat
    35161 ctgatcgtcg ccgaactctt cgacaccgtc ggaccgatga tcgccgcgcg aatggaactg
    35221 ccctggtacc aggtcggcat cgggcccgcg ctccccgcag tgctggccgg tgagatcgac
    35281 cgatccgtgc tgccgcacta cgagcgcgcg ggcgtgaagc ccgtacccgc cgccggctac
    35341 ctcgatacct gtccggctgc gttgcaggac ccggagtggg tcagcgagat tccggtgctc
    35401 ccggttcggg tgggcgccca tcgcaggccg aacccttcgg gcatcgagct cccccgcttc
    35461 accgatccgt cgaagcccac cgtgttgctc accctgggga cggtgttctc cgaggcgtcg
    35521 accttggctg cgctctgctc ggcggtcgcg caggccgatg tcaacgtgct ggccacgctc
    35581 ggggtcgttc tggaggagtc gccggaggtc accggtcgtg gtgaggttcg gttcgtgccg
    35641 ttcgcgccgt tggaggagct gctgaaggac gtcacgttgg tggtggccgc cggtggttcc
    35701 gggacggtgc tgggcacgct gagccgtggc atcccgctgg tgttgtggcc gcagggcgcc
    35761 gaccagccga tcaacgcggc ccgggcggct gcggcgggcg tggcgttggt ggcgggctcg
    35821 gcggacgaga ccagcgaggc ggtggcccgt gccctacagg atgagcagct gcacaccagg
    35881 gccgcgcagg tggcggcgga caacgagctt cgacccacgc ccgccgagat cgtcgcgacc
    35941 ctgacggccg gctcgcgtta ggactcggac cgagaatatc caccgctgac cgaacacctg
    36001 ttcttgcgac acccggtcgg ctcgctgcgt agccgctgtc gagccgaccg gccgcgtcgg
    36061 cccgttcttc gggccgggta gctcctctcg cacgatcgac cgcgatcccc gggcgacccg
    36121 ccctggtcga gcctgccctt ctcccttctc ccgcacgcgt ttctccgtgc gatgaatcct
    36181 tggcatggaa aggaattccg tgaccccgaa aacgagatcc gagcgtcccc gtaggcgctg
    36241 ggcgcgatgg agtctaatca cgatggcggc actgttcgcc gggacgctcg gcgccgccgg
    36301 gatctatttt ctccaggcta gaatcgatac ggtcggcgct gtcgatttcg ataccgagct
    36361 gacgattccg ccgctggccg aatcggagca ggacgattcc ggtgcgcggg tgttcgacct
    36421 gaccattcag tccggtgcga ccgagttcgt ggcgggcggt gcgaccgaca cctggggcgt
    36481 caacggcacg ttcctgggcc cgacgatccg cgcgcaacgt ggggaacggg tcgagttcgc
    36541 cgtcaccaac gatgtcgacg aggagacctc gatccactgg catgggatgc ggctgcctgc
    36601 cgagatggac ggcggcccgc accaaccgat catgccgggc gagacctggc gtccgcattg
    36661 gacggtggac cagcccgcct cgacgctctg gtatcacccg cacgtgcacg gcaagaccgc
    36721 ggcgcacacc tatcgcgggg tggcgggcat gttcattctc gacgacgaga acaccgcgag
    36781 cctgaatctt cctgcggact atggcgtcga cgatatcccg ctgatcgtgc aggaccgaaa
    36841 gttcgatgcg gacaatcagt tcgacgactc cattccgttg ggcagcacct cgggaactct
    36901 cggcgacgag attctggtca atggttccca tggcccctat cgggaggtga cgacccgact
    36961 ggtgcgcttg cggttactca atgcctcgaa tgcgcggatg tacaacttcg gtttctccga
    37021 tgatcgacca ttccagctca tcggtaccga cggcgggctg ctccccgaag catgggagac
    37081 cgatcgaatc cagttgtcgg cgggtgaacg cgcggagatc gtggtggcct tcgaaccggg
    37141 cgataccgtc gagctgcggt cgtatgcggc cgagttcgac ctcggcgacc agacagccga
    37201 tcggctcagt ggggagcagg acgagctcga catcgtccag ttccgggccg ccgatgccct
    37261 ggccgatgag accgagatcc ccgagacgtt ggcgcccgcg cccgatctcg gtaccgagaa
    37321 cgtcgccgag gtgcgcacct tcgatctgga gggacgcagc atcaacggac agcagatgca
    37381 gatggaccgc atcgacttcg gggttcgcga gggagacacc gaggtctggg aggtcaccaa
    37441 ccacaacggc tatctgcaca acttccacgt gcatgacgtg cagttccagg tggtggacgt
    37501 cgatggcgtc gagccgccgc cgcagctgcg cgggtggaag gacaccgtgc tgttggtgcc
    37561 ggatctgcgc tatcggttgg cgatgcggtt cagcgaccac accgatccga atgtgcccta
    37621 catgttccac tgccatcttc tgacgcacga ggacgagggg atgatggggc agttcgtggt
    37681 gctgggcgag gatgaggaga tcggtcgggt gccgcagcac ggcggccacg accacggcga
    37741 ctgaccgcgc gaacgccgcc gagccgccga ggtcgcccgg tcagctggtc ggcaccggag
    37801 tcagcagggt gccctcggcc atgaagtggt gcaggttgcg gaaggccaga tcgcccatgg
    37861 cctcgcgggt ctcggtggtg ccgctggcga tgtgtggcag cagcacgacc gaatcgagcc
    37921 cgagcaactc ggcgggaacg ttgggttcgt cgacgaagac gtccagtgcc gcgcccgcga
    37981 tgcggcccgc caccagcgct gccaccaggg ccggttcgtc gacgacgctg cctcgggcga
    38041 cgttgaccag gaagccctgc ggcccgaggg cggtcagcac ctcttcggag accagaccac
    38101 gggtgctcgc cccgcctgcc gcggtcacca ccacgacgtc ggactcggcg gccagcgtgg
    38161 tcgccgaatc gacgtaccgg taggaggcct cggccaccgg gcggcgggag tggtagacga
    38221 tctcggcgtc gaagccggtc agtcggcggg cgacggcctg gccgatccgg cccaggccga
    38281 ggatgccgat ccgcttgccg ctcaccttgg tggtgagcgg ataggcgccg ggtttccagt
    38341 cgcctcggcg cacatagcgg tcggcggcgc tgagtttgcg catcacgtcg atcagcgcgc
    38401 cgacggcgag gtcggcgacg cagtcggtga ggacgtcggg ggtgttggag acgtcgatgc
    38461 ccctgctgcg ggcgcgggcg acgtcggtgg tctcgtagcc cacgccgaag tgcacgatcg
    38521 cgccgaggtt gggcagcgcg tccatcagtt cgtggctgac cccgatccga gcggtggtga
    38581 cgaccgcgac cacctcggcg ccgcgctcgg cgaggaaggc ggccggatcg tcctgttcgg
    38641 acagcaccac ggtgcggtgg ttcgcggcga gcgaggccgt caacgagggc agcagcggga
    38701 tggtctgtag aacgatgccc tcggatgtcg gagtggccgt cacgtcgatc tccttgcgtt
    38761 cttcatcggc gtgggccgca gggagtcgtc ggcgctcccg ccggtcgctg tccgcagtcc
    38821 ggtcgggcga gggcggcggg gccacacctg gaattggggc gcaggcggcg acagtagatg
    38881 actaccatcg ccgcctgcga gttcgcttcg gccgatgccg tcgtcagtcg cggccgagtt
    38941 cgccgtcgat ccgacgccag aggccgaggg tgttctcccg tcgaagctcg acgggcaaca
    39001 gggcgtccgg gacgttctgg tagctcaccg ggcgcaggaa tcgctcgatc gccagggtgc
    39061 cgaccgaggt ggtggcaggc gccgaggtcg cggggaacgg cccgccgtgc acgacggcgt
    39121 tgccgacctc cacgccggtg ggccagccgc cgaagagcac ccgaccggcc agcacctcca
    39181 acaccggcag caggtcggcg acgaccgggt ggtcgctctc ctgggcgtgc acggtggcgg
    39241 tgagctgacc ttcgagggag gtgaggatct cgtggagctg gtcgaggtcg cgcacccgca
    39301 cgatcagcga ggtcgcaccg aagatctcgt cccgcagcga ttcgtcggcg aggaaggtcg
    39361 cgccgtcggt ggtgtagaga cccacctgtc cgcaggccgc gatctcctcg tcggtcggtc
    39421 cgctcgccac ctcggtgacg ccgggccgcg cggcgagctg ctccacgccc tgctggtagg
    39481 cctgctggat tccggtggtc agcatcggcg cggccggcgc cagtccgacc gcggccctgg
    39541 cggcggcgac gaactcgtcg aagccggtgt cctcgccctc gcccgccacc gcgaagacca
    39601 ggccggggct ggtgcacagc tgtcctgcgc cggtggtgac cgagacgatg aactcgcggc
    39661 ccaggtcggc accgcgttcg gccagcgcgc cggggagcag cacgaccggg ttgacgctgg
    39721 acatctcggc gtagaccggg atcggcaccg ctcgttgcgc tgcggcggcg accagggcca
    39781 gcccgccgga gcgggagccg gtgaacccga ctgccgcgat cgcggggtcc tgaaccaggg
    39841 ccgtgcccag ttcgcggccc gcgccgaaga gcagcgagaa ggtgccctcg gggagtccgt
    39901 gctcggcgac ggcggcccgg atggcgcggc cgactaattc cgaggtgccg gggtggctgc
    39961 tgtgtgcctt gaccaccacg ggcgcaccgg cggccagggc ggaggcggtg tcgccgcctg
    40021 ccaccgagaa cgcgagcggg aagttgctgg cggcgaacac ggccaccggg ccgagcggca
    40081 ccttgcgctg gcgcaggtcc ggcttgggca gcgggacccg gtcggcgttg ggggtgtcga
    40141 gtcggacgcc gagccagtcg cctgcccgca cggtggtggc gaagaggcgc agctggttga
    40201 cggtgcgcgc cagttcaccg cgtactcggg cctcggggat gccgctctcg gcgacgaccc
    40261 gctcgacgag gacgtcgccg agggcgtcga tgttgcccgc ggcggtgtcg aggaaggcgg
    40321 cgcgcttctc cagggaggtc gcccggtaga cgccgaaggc ctccttggcg agccgggtgg
    40381 cgcgggccac ctcggcggcg ccgcccagcc cgtaggccgg ttccagggat tggccggtgc
    40441 gcgggttcac gccgaacacg gtgccctgct cgccgtggac gtcctgggag ccgatgagca
    40501 tcgagccggt gagggtcgcg gtggcggaag cgtcggtcga agaggtcatg ccttggtcac
    40561 cttcgtcacg agtgcggtga ggtcgtcgag ttcggccgag gtcaggtcgg tcagcggcgg
    40621 ccggaccggc ccggcgctgc gaccgatgac ggtcaagcct gccttgacga tggacaccgc
    40681 atagcctgcc cgacgattgc ggatgtcgag gtagggcagc acgaactcgt cgagcttgcg
    40741 gtacaccgtc tcggcgtccc tggcgcgcac ggcggcgtag aactccacgg cccactccgg
    40801 caggaagttg aagatcgccg acgagtaggt ggtgacaccc atctcgaggt agggcagcgc
    40861 gtaggtctcg gcggtgggca gtccgccgat ggacagcagg cggtcgccca gccgcgcgta
    40921 gatgcgggtc atgaggtcga cgtcgccgat gccgtccttg aacccgatga agttcgggca
    40981 ttcgtcggcg agtcgttgca cggcgtcgaa gccgaaggcg gcgttggccc ggtggtacac
    41041 gaccacaccg agcgaggtgg ccgcgcagac cgccttgacg tgctcgacca ggccgtcctg
    41101 ggacagttcg gtgaggtagg gcggcagcag gaacacgccg tgcgcgcctg cggcctcggc
    41161 gtcgcgggcc atcgcgacgg cctgggcggt gccgtagccg gcgggtgcga tgaccggctt
    41221 gtccccgggc atcgcggcga cggcggcgcg cacgatgcgg ccgacctcgt cggggacgag
    41281 ggagaagaat tcaccggtgc cacctgcggc gaacaggccc gaagcggcgt acgagccgag
    41341 ccaagcgatg tggtcgcggt agccgtcctc gtcgaaggcc aactccgctg tcgcgtgcgt
    41401 gaccgggaag gacagcaggc ccgtgccgag ggtggtccgc agttcctctg gggtgtacag
    41461 cgtcatggct caggctccag tgtcggggga ctcccgccga ggctagggag ttccccgata
    41521 cctgtctaac acgattaacg cattgactga taccttctct gcatcgagga ggtttcgatg
    41581 gccgcaccgt tcacgttgga gcagctccga ggcttcgtcg ccgtggccga ggaagcccac
    41641 ttcgggcggg ccgcggcgcg cttgcagatg acgcagccgc cgttgagtcg ccaggtccag
    41701 aagttggagc gttcgctggg cgtcgacctg ctcgtccgga ccacccgcgc cgtgttgccc
    41761 accccggcgg gcgaggcctt cctgaccgag gcccggcgca tcctgaatct ggccgatgcc
    41821 gcgccatcgg cagctcagca cgccgccgac ggggccacgg gttcgttgca catcggtttc
    41881 accgcggtca cggcgttgac cgtgttgggc agctggatca aggtcgccaa cacccggttg
    41941 cccgccgtcc gactcacgct caccgagatg gtgaccaggg accaggtgga ggccctgctg
    42001 gcgggcgagt tgagcgtcgg actggtccga ggcgtggccg ccaccgatgt gctcagcgtc
    42061 cgacgcgtcc acgccgagag cctggtgctg gcctgccccg gcgggcatcc cctgaccacg
    42121 ctgggcaggc cgccgaccct ggccgacgtc gccgagcacg ccgtcatcac ctacagcccc
    42181 gtcgaggccc gttacctgca cgaactcgtc atcacggtgt tccgcaacgc cggcgtggag
    42241 ccacgctacg tgcagcggat cggccaggtg cagagcctgc tggcactggt ggacgcgggc
    42301 ctgggggtgg cactcgtgcc gaggtcgtcc tcgcgcctgc gactgcccaa tctggccttc
    42361 accgagattg cgggtcttgc gcccgacctc gtcgaggcgc agtgtgcatg gcgtagcgac
    42421 cacgacgatc cggcgctggc tgcgctgctc cgactgactg cgctctgatc cggtcgaact
    42481 cttgacggcc tttggcctca agcctacggt ctgtctaccc atacagacca agtgcgcgtt
    42541 tgtagacact ctggcgccag accggcccga tcagcaccca ccacgactcc cggagagacg
    42601 atgctgtctt ccgtgcaccg ccccgtccac atcggacggt cccgagccaa gagcggactc
    42661 gccgcgatgc tggttctcgc ttgcacggcc acgaccgcgt gctccgtggc caacagcgac
    42721 agcgcgggtg acgcgggcga cgccggggac tccctgcgca tcgtgctcgc tcaggaaccg
    42781 ccgaccctgg aaccctgcga ggcatcactg acgtccacgg gcgtcgtcac ccgctccaac
    42841 atcagcgaac cgctgatcga gcgcgatccg accaccggtg agctggaacc actgttggcc
    42901 accgaatggg agcaggactc cgacaccgag tggaccctgc aggtccgcga cgacgtcacc
    42961 ttccacgatg gtgccgagtt caccgccgag gatgccgcct tctccatcga ccgcgccgtc
    43021 aactccacgt tggcctgcaa cgtcgagggc tacgtcttcg gtgacgacga cttaggtatc
    43081 gaggtcgtcg acgacacgac gctgaccatc accaccgcgc gtcccgaccc gatccttccg
    43141 ttgcggttga gcttcatcga ggtcgtgccg cgcaccacca gcaccgaggc caaggtccgc
    43201 gaacccatcg gcaccggccc gtacgcggtg gcctcctggg agaccggcgt ctccatcaac
    43261 ctgcagcgtc acgacgacta ctggggcgag gccccggact tcgggcgggt ccgctacgtc
    43321 tggcggtccg agtccagtgt gcgcgcggcg atgatcgcca ccgacgaggc cgacattgcc
    43381 acggcgctca acccggagga cgccaccgag gagaactcgc tgccgtaccc caacaacgag
    43441 accaccgccc tgcgattgga cggcacccag gcgccgttgg acgacctgcg ggtgcgcaag
    43501 gccatcggat tggccgtcga ccgacacggc atcgtcgatg ccctattcga tggtctggcg
    43561 caaccggccg cgcaactcgt accggagggc gtcgtcggct acaaccccga gttgacggcc
    43621 gcaccggccg atccggaggc cgcccgggca ttggtcgagg aggccgccga cgacggcgtc
    43681 ccggtcgacc gcgagatcac gctgatcgct cgcaacgaca tgttcccgag ggtggccgag
    43741 accgccgagg ccctgcaata ccagctggcg gagatcggcc tacaggtgaa gatccagatg
    43801 gccgacaccg ccgcccacct ggaatatcag ctccgcccgt tccccgagga cgtcgggccg
    43861 gtcgcgctgc tgatcatgca cggcaatcag gccggtgacg cgggcttcac caccagccaa
    43921 tacctgatct ccgacggccc gcagtccacc ttcggcaccg atgcgctgga cgaacaggtc
    43981 gccgaggccg acgaggccct cgacgacgag cgacaggacg cgttcgcgga ggtgttcgcc
    44041 gagcagaacg agtccgtcgc ccagtacgcc cacctcgccc acatgcaggg gttgctgggc
    44101 atctcccctc gggtgtccta cgagccgaac tccgccaccg gggacgagat gcgtctcgcc
    44161 gacatccggt cgcagcgctg agaggaccga ccatgttgac cttcctgcgc aaacgcatcg
    44221 tctccagcgc gatccccctg gtcgtcgtcg tcctcggcgt gttctgcctg gctcggctca
    44281 ccggcaatcc cgtgaacctg tatctgccgg tgagcgccac ggccgagcaa cgcgccgcgt
    44341 tctcggcggc caacggattc gaccagccga tctacatcca gctgttggac tacctcggcc
    44401 aggtcgtccg cctcgacttc ggcgtctcgc tgcgcaccgg ccagcccgcg ggcgagatgg
    44461 tgctcgcggc gttccccgcc actctgcagc tggccgccgt gacgatggtg atcgccatcg
    44521 tcggcgcggt gctgctaggc agtctggccg cctaccggcc gaactcgccc gccgaccggt
    44581 ccgcgagctt cctgtccatg accgcggcca gcatcccgga cttctggttc gccatcatgg
    44641 gcgtgctgat cctgggcgtc ggcttggaat ggctgccgac ctccggggtc gacggcggca
    44701 tcgaggtgtg gatcctgccc atcgcaaccc tgctgattcg cccgttcggc gtgttggtgc
    44761 aggtggtacg cggtgcgatg gtggccgcgc tgtccgcgcc ctacgtcaag gtggcccgca
    44821 gtaagggggc cagcgagtcc cgggtggtgt tcgggcacgc cttgcgcaat gcctcggttc
    44881 cggcgttgac cgtggcgggc gatctcacca tcggcctggt caacggcgcg gtggtcgtcg
    44941 agaccatctt cggttggccg ggaatcggca agctgatgat cgactcgatc ctgcaacgcg
    45001 acttcgccgt gcttcaggcg gccgtgttgt tgaccgccgt gacgatcttc gtgctgaaca
    45061 tcctcatcga cgtctgctac gccctgctcg acaaccgtgt ccgccaatcc gtgcccgcgt
    45121 gaggaaggag ccactcgatg tctgagagaa ccgaagacca gactcgcgac gatccggcgc
    45181 gggccgagcc cgctccgccc gccgcccgcc gcaccagttg gtggaccatg ctcggccggg
    45241 actccttcgc cgccgtggcg gccgtggtgc tcggcggggt gctgttggtc tcggcggcgg
    45301 cgccgctgtt cctcggcgac cgcgccgtcc gccaggacct ctccgcttcg ctgcgtccgc
    45361 cgtccttcga ccacggattc ttcggtctgc tgggcaccga cgtcctcggc cgcagtgtgt
    45421 tggcccggct gatcgaggcg ggcggcacca cgctgtcggt cgcgattccc gccgtggtgt
    45481 tgtcgctgct gatcggctcg tcgtggggca tgtgggccgg ctaccggggt ggctggcggg
    45541 agaacgtgtc gatgcggatc gccgacatca tcctgagctt cccatcgctg ctgctggccg
    45601 tggtcgtgct ctacgtgttc gaaccgagcg tggccaacat cgtggcgatc ctggcggtgg
    45661 cccgcatccc catctacctg cggaccgccc gcgccgaggc cgccgagctg aagagccggt
    45721 tgttcgtcga cgcggctcgc accttcggca ccaagaccgg gccgaccatc ttccgacacg
    45781 ttgcgccgat cgcgctgccc accctgctga cggtcgccac cctggacttc tgcttcgtga
    45841 tgctcaccga gtcctcgctg agcttcctcg ggatcggcat ccagccgccc gaggtgagct
    45901 ggggactgat ggtcgcccag ggcaggcagt atctccagac cgcctggtgg atcgcggtgc
    45961 t
//
