LOCUS       NZ_CP014859            31297 bp    DNA     circular CON 20-NOV-2024
DEFINITION  Actinoalloteichus hymeniacidonis strain HPA177 chromosome, complete
            genome.
ACCESSION   NZ_CP014859
VERSION     NZ_CP014859.1
KEYWORDS    RefSeq.
SOURCE      Actinoalloteichus hymeniacidonis
  ORGANISM  Actinoalloteichus hymeniacidonis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Actinoalloteichus.
REFERENCE   1  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J.,
            Zotchev,S.B. and Ruckert,C.
  TITLE     Complete genome sequence of the actinomycete Actinoalloteichus
            hymeniacidonis type strain HPA 177T isolated from a marine sponge
  JOURNAL   Stand Genomic Sci 11, 91 (2016)
   PUBMED   28031775
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J., Zotchev,S.
            and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2016) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Coverage                   :: 159x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001747425.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 01:17:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,434
            CDSs (total)                      :: 5,374
            Genes (coding)                    :: 5,337
            CDSs (with protein)               :: 5,337
            Genes (RNA)                       :: 60
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 3 of 37
            Pseudo Genes (incomplete)         :: 34 of 37
            Pseudo Genes (internal stop)      :: 1 of 37
            Pseudo Genes (multiple problems)  :: 1 of 37
            CRISPR Arrays                     :: 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:46:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4379785
            Orig. end                         :: 4411082
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014859.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..31297
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="20"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..31297
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..31297
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:21297]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..21297
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    858..872
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     misc_feature    1034..1047
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.74"
                     /tool="antismash"
     misc_feature    complement(1436..1450)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            complement(1606..2907)
                     /locus_tag="TL08_RS18230"
                     /old_locus_tag="TL08_18455"
     CDS             complement(1606..2907)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015105624.1"
                     /locus_tag="TL08_RS18230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18455"
                     /product="serine hydrolase"
                     /protein_id="WP_069850701.1"
                     /transl_table=11
                     /translation="MNIRYAGTTRSTRRATATVAGTLTVLALVTACAGTADTGMPSATP
                     SGDVAAQHSGAADTPTPELGVLLDELVDAGAPGVVALVDDGAGEPIELTGQAGWVEQRL
                     SVQDQFRMGSNTKTMIGVLTLQQVADGTLSLSDTVEKWLPAAIPNGDEITLRMLLNHTS
                     GLDDYVLHPEVLGLITGNSTTPLPPARLLEAAVELPALAAPGTAYAYSNANYIALGMVL
                     ERATEQQVADLLQQRILDPLALTDTYLATDGESRDGDLLAEGYEPDAEHLAPLLPPGTP
                     EGVAFVGEPRDDHVEVSSIDPSWSWTAGAVVSTPSDWQRFLRALLSGSVLPPAQLAEMK
                     ETVVEFPGEPASARYGLGLEQYQSPCGSVWGHTGGIPGYASANYVDESGTRSVTVVTTT
                     QFGLRTEALGAAERALIDGAVCAMSGEPLPATEE"
     gene            complement(3093..3758)
                     /locus_tag="TL08_RS18235"
                     /old_locus_tag="TL08_18460"
     CDS             complement(3093..3758)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005440594.1"
                     /locus_tag="TL08_RS18235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18460"
                     /product="response regulator transcription factor"
                     /protein_id="WP_069850703.1"
                     /transl_table=11
                     /translation="MAEQITVVVVDDEQLVRIGLTTILDAQADLVVAGTAADGEAAIDV
                     CTQLKPDVLLLDIRMPRRDGLWALTELGRRGLVGPGKTRVLMLTTFDLDEYVDEALAAG
                     AAGFLLKSSSYEELTAAVRAAALGHSALSPVVTRRIIEGHLAARHRPDNGELARLAGLT
                     ARERLVLRLVGDGLSNAEIAERLVVSLHTVKTHVSRMLAKTGCQSRAQAAVLARNTLS"
     gene            complement(3751..4941)
                     /locus_tag="TL08_RS18240"
                     /old_locus_tag="TL08_18465"
     CDS             complement(3751..4941)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="TL08_RS18240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18465"
                     /product="sensor histidine kinase"
                     /protein_id="WP_069853875.1"
                     /transl_table=11
                     /translation="MTEQLRRRREWIADAGLIALTLLAPALLQPSTDSTATAWLLLACF
                     EAVALAALVVRRRMPITAFLVIVAALVATIVAGAAVGARLSPLAFLSLAVVLYNLGNHG
                     ARPARNGVAALVGGLMVGIGLWINWMTVSAVDFRGGPDVLAVLAPMPLAWALGFGARSR
                     RVLLVAAEQRAADATREQHLRAEQAAQQERVRIAREMHDLVAHSLTLLIVHAEALRSRS
                     AELPDWARTQSDGLAVAGRQISGELHDLLRMLRDPADAVPLRPMPDLGDLPALLDGHRA
                     EGGTVEARLRGELESLPRPTQLAGYRIVQESLTNARRHAPGAPVVLTLESDAAGMLIDV
                     VNRPAVRAGTQGAGAGLGLISMRERVDALAGELVVGPTSDGGFRITATLPSGVVGG"
     misc_feature    complement(4819..4821)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5139..5154
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            5209..6195
                     /gene="ispH"
                     /gene_synonym="lytB"
                     /locus_tag="TL08_RS18245"
                     /old_locus_tag="TL08_18470"
     CDS             5209..6195
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /GO_process="GO:0050992 - dimethylallyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ispH"
                     /gene_synonym="lytB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673285.1"
                     /locus_tag="TL08_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18470"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_069850705.1"
                     /transl_table=11
                     /translation="MGDTSTDEQTKAAGTRRILLAGPRSFCAGVERAIEIVERALRSHP
                     GPIYVRKQIVHNISVVEDFTRRGVIFVEELDEVPNGSTVVFSAHGVSPAVREDAARRQL
                     DVIDGTCPLVTKVHAKARRFAARGDTVVLIGHGGHEEVEGTLGEAPESIVLVETLEDVQ
                     NLEIPDPERASYLTQTTLAVDDTAEFIGALRQRFPLLHEPSSEDICYATTNRQHALGAI
                     VDESELVLVVGSTNSSNSVRLVELSRRQGTPAYLIDSSKDIQPEWLDGVTTIGLTAGAS
                     APPALVDEVVGALRELGPVSVEEREISRETTHFELPAAVRDLPDRAQ"
     misc_feature    6034..6036
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6358..8166
                     /locus_tag="TL08_RS18250"
                     /old_locus_tag="TL08_18475"
     CDS             6358..8166
                     /EC_number="2.2.1.7"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673284.1"
                     /locus_tag="TL08_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18475"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_069850707.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 4.3e-86,
                     bitscore: 286.8, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.8e-05, bitscore:
                     22.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTLLSHITSPQRLKELPPERLGTLATEIREFLIDKVCRAGGH
                     LGPNLGVVELTIALHRVFDSPTDRIVFDTGHQSYVHKILTGRHDDFDSLRTAGGLSGYP
                     NQAESPHDHVENSHASTALSYADGLARAVRLRGEDSRVVAVIGDGALTGGLAWEAMNNL
                     GRGEHPVVIVLNDNGRSYEPTVGGLADHLAELRRPGSTGRNLFEDVGLAYLGPVDGHDT
                     AAVEEACRQAVRLCRPVVVHCVTEKGRGYSHAEQDVADHMHGIGVIDPETGRSSRKSAP
                     TWTAVFGQEMAAIGATHPEVVALTAAMLRPVGLHAFAQRFPDRIVDVGIAEQHAMTSAA
                     GLAMGGLHPVVCLYATFLNRAIDQVLMDIALHRLPVTIVLDRAGVTGPDGASHHGMWDL
                     ALLSAVPGMRVAAPRDSVQLARQLSEAVAITDGPTALRFPKAAAGDEIAAVGTMDGLDI
                     LHRSRSLPLDVLLVCTGVLAGPAKHAAESIAEDGIGVTVVDPRWLLPVNPTLVHLASRH
                     RVVLTVEDGMRVGGFGSAVAQACSDARVSAPVRNLGLPREFLDHGSRGAILAEHGLTAE
                     SIAATARALLEASTEGQTTPFEGILR"
     gene            8184..9353
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="TL08_RS18255"
                     /old_locus_tag="TL08_18480"
     CDS             8184..9353
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity (ferredoxin) [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682003.1"
                     /locus_tag="TL08_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18480"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_069853876.1"
                     /transl_table=11
                     /translation="MPTLPPPVLAPRRQTRQLQVGSVGVGSQHPVSVQSMTTTVTADVN
                     ATLQQIAELTASGCDIVRVACPTQDDADALATIAAKSQIPVIADIHFQPKYVFAAIEAG
                     CAAVRVNPGNIKKFDDKVKEIAHAARDHKTPIRIGVNAGSLDPRLLAKHGKATPEALVE
                     SALWEASLFAEHDFHDIKISVKHNDPVVMVRAYELLSEACDYPLHLGVTEAGPAFQGTI
                     KSAVAFGALLRQGIGDTIRVSLSAPPVEEIKVGTQILQSLNLRPRKLEIVSCPSCGRAQ
                     VDVYTLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGKVI
                     KTVPEHQIVETLIDEAMRIAEETEAAGEDAEAIAGGTGPVVSVVGGQPL"
     gene            9350..9979
                     /locus_tag="TL08_RS18260"
                     /old_locus_tag="TL08_18485"
     CDS             9350..9979
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313970.1"
                     /locus_tag="TL08_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18485"
                     /product="response regulator transcription factor"
                     /protein_id="WP_236750318.1"
                     /transl_table=11
                     /translation="MSSVRVLVLASDPLSRMAIVGHLDAQPRIEVVAVEQQQRAGLDVI
                     VFVADRVNVEALGRLRRMKAILSAPVVLVTGEIGSADVFTVVESNVVAVLPRQTITGPQ
                     IEEAVLTAAAGGGMLPSAMLGELLKQVKRLQHEVLLPHGLHASGLNAREIEVLRLMSDG
                     LDTAEIAVKLGYSERLVKRVISTVTSRLGLHNRPHAVAYALRKGVI"
     gene            complement(10001..10750)
                     /locus_tag="TL08_RS18265"
                     /old_locus_tag="TL08_18490"
     CDS             complement(10001..10750)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TS_Pyr4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673281.1"
                     /locus_tag="TL08_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18490"
                     /product="hypothetical protein"
                     /protein_id="WP_236750319.1"
                     /sec_met_domain="TS_Pyr4 (E-value: 5.1e-18, bitscore: 63.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLDWLPPPLFPMSEIAPVTVGPADVPDWLFWSVAGPTVLGWLIT
                     YLLAIRQTVLDGRVAIPAYLVAINVAWEFSLTFLLEQTSTQRGINLVWLVFNLVLLSLV
                     FRYGRNDYPTLTQKAFAWSLVGVFVWAALLIMAGANEFHDRDGMYIGMILNVPLSAAFI
                     FMLRRRGSSIGQSMYLAVAKLGGSFFAGLTGFILYPSRLLFFVIVPTMVALDILYVVLL
                     HRRMRAEGRSPWAWRTRPHAVEEPATR"
     misc_feature    complement(10352..10354)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10864..12057)
                     /locus_tag="TL08_RS18270"
                     /old_locus_tag="TL08_18495"
     CDS             complement(10864..12057)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673280.1"
                     /locus_tag="TL08_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18495"
                     /product="hypothetical protein"
                     /protein_id="WP_069850709.1"
                     /transl_table=11
                     /translation="MTHLRTDPVNLRSELLDRVHAIGPVLAAGVAEGDRERRLPQATLQ
                     AIEESQVGMLWTARSYGGLETDVRTLSEVTKALSHYCPSTSWVVNNINGSNLMASRFGQ
                     QARDEVFGADPGAKLASIFVAAGDAVRTDGGCLLSGRWPYASGILHDDWAVLSAKEIDA
                     DGELIRPVSVLVPVADLTVDDTWATVGMRATGSHTAVATEVFVPDHRIIPVDRQLGRQN
                     AEDVSLTPLFRTPAVAAMAVICASVVVGIGQAALDLVVDRAPSRGIAPSLYANQTSSPT
                     FVSGLGGTALTLDSAQLHVSRAADVIDAAAEAAVALPETELRRIRGDVGHAVNLVTIAL
                     NELLWAHGAASFAESNPLQQYWRDANTAARHAMLNVHIGRELYGGAFFGLDLIVRGL"
     gene            complement(12263..12655)
                     /locus_tag="TL08_RS18275"
                     /old_locus_tag="TL08_18500"
     CDS             complement(12263..12655)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673278.1"
                     /locus_tag="TL08_RS18275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18500"
                     /product="limonene-1,2-epoxide hydrolase family protein"
                     /protein_id="WP_236750320.1"
                     /sec_met_domain="PF07366 (E-value: 5.3e-05, bitscore: 21.3,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIDNERVVRDFLGAMGPTPADIGAAVDRFLTEDCVWENPGSPVC
                     RGREQIMALMPPAFAQLVVRFRSVAVTGDTVLVERVEDMLRTDGTPIAANLKVAAAFEL
                     RDGRISAWRDYFDITRLISESEDTAG"
     gene            complement(12660..14453)
                     /locus_tag="TL08_RS18280"
                     /old_locus_tag="TL08_18505"
     CDS             complement(12660..14453)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673277.1"
                     /locus_tag="TL08_RS18280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18505"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_069853880.1"
                     /transl_table=11
                     /translation="MSDVEVSVLIVGGGGCGLTTSLFLSDLGVDHLLVERRESTSVLPR
                     AHYLNQRTMEIFRQHGVAEDVYRESCPLENMSEVVWRTSLAGDGPLDGRDLHRMDAFGG
                     GTTAGPYAADSPSPSTNFPQHNLEPVLRRHADERAPDRVRFNHVMEEFTQDEDGVTAVV
                     TDRETGESQTIRARYLVAADGGRSIGASLGVEMAGEPGAFQVMSVHFTADLSESWPGDS
                     VLMTHFVSPDGGPISRYGIVAVGPGWGLHSQDWALHYHIPVGSTPDFSSETAVLRVREL
                     LKLPDLEVAVHQVSHYVPEAVIADTFRVGRVFLAGDAAHRQPPATGLGLNSAIQDAHNL
                     AWKLAAVLDGQADDALLDTFEQERLPVAHRNVSWAMYALRNHAVAHAGLGLLPGQPLEA
                     TQRNFLELFSDTPMGETRRIRAHEVFTTQRVEYQAHDIEIGFSYAAGALVADESQPPPR
                     DPMGGRYHPVTRPGHRLPHVWLRKDGERVSSHDLVGAHGGFVLITGPENSAWVDAAERV
                     AATHGVALQVVSVGTESADYQDVDGGWAALRQVPGEGAVLVRPDNHVAWRTERAGTSPA
                     SELTEVFARILGKPALVASGG"
     misc_feature    complement(14382..14384)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14658..14867)
                     /locus_tag="TL08_RS18285"
                     /old_locus_tag="TL08_18510"
     CDS             complement(14658..14867)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023831.1"
                     /locus_tag="TL08_RS18285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18510"
                     /product="ferredoxin"
                     /protein_id="WP_069850711.1"
                     /transl_table=11
                     /translation="MKIEIDEGKCVAAGHCVMVAAEVFDQRDEDGVVVLLDPAPPEHLH
                     EQVREAALLCPANAILSGGRDSAS"
     gene            complement(14892..16085)
                     /locus_tag="TL08_RS18290"
                     /old_locus_tag="TL08_18515"
     CDS             complement(14892..16085)
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673275.1"
                     /locus_tag="TL08_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18515"
                     /product="cytochrome P450"
                     /protein_id="WP_069850712.1"
                     /sec_met_domain="p450 (E-value: 5.2e-22, bitscore: 76.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEPKVLPTAARATGCPYAPAAELYEMQKSEELPRIRIPNPMIGE
                     FEAVALTRYSDIRSALNDDRLQMGFVFDPDAPRTMLNQPGNLLNYNGAEHSRLRRMLTA
                     AFTVKRIRALQPMVEEVVAERLDALAAEGPGVDLVTEFSTPIPTQVICHLLGVPYADRA
                     DFQRRAKVGLDINTSREKQIENLAELDAYMAELVAAHRREPGDNMLGILVRDHGPELTD
                     DELVGIGNMLLIAGHETTASMLSAGTALLLQHPEQLAVVRDDPSAIDGAIEELLRFCSP
                     ATTMPRQAAADLQVRDQVIKKGERVMTSILVANRDPDIEAPDLDTLDVRRPPQPHITFG
                     YGAHQCLGQQLARLELRVALPALFNRFPTLAVGVDHDEIDYRTTALVFGVNRLPVTW"
     gene            16379..17020
                     /locus_tag="TL08_RS18295"
                     /old_locus_tag="TL08_18520"
     CDS             16379..17020
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="TL08_RS18295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18520"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069850714.1"
                     /transl_table=11
                     /translation="MTTDATKETADRGRGRPPMSQQRRDVVRLQIAAAALDLFRAQGVS
                     ATSVDQIAAELEISTRTLWRYTSSKEACIEPLLTHGISVVVQRLRDWPRDQPLLAHLLH
                     EDDLYEDVSESTLELVRLMRTEPGLMSVWLRTHLDAEQAFASVLAERTGRSADALETKV
                     QAGMLNVALRLAMEHHAWRADHPQRDSTGPDNLTEATELALRTAIAGLAV"
     gene            17183..18172
                     /locus_tag="TL08_RS18300"
                     /old_locus_tag="TL08_18525"
     CDS             17183..18172
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.5"
                     /locus_tag="TL08_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18525"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_069850716.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.1e-41, bitscore:
                     138.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEIDVPQVADLEIAALVRAEVERRWPLDVQGIEELARYGLIPFG
                     KMMGPWLLIRSSLATGGDVKSVLPAAVAVECIQVGAMMHDDIVDGDPQRRSKLAAHAAF
                     GQGTAIIGGDGLFFHGFAALADCQRAGAPVELVGAALTILSQTGLRIGNAAVEEIRMGR
                     SICSTSTYLNMIKDKSGALLWMACGVGATLAGADRKSLAALRSYSDLLGVGYQIRDDLM
                     AYDGTRAGKPNISDIRNGRPTLPVLLAHRRSTREQQRLIEHLLADTTTPVEERHEAMAE
                     IVEVSGAVRSARRMSHLYAHLAGRALDELPPSVHRDVLVELTVPGRLV"
     misc_feature    17921..17923
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18202..18825
                     /locus_tag="TL08_RS18305"
                     /old_locus_tag="TL08_18530"
     CDS             18202..18825
                     /GO_function="GO:0004833 - tryptophan 2,3-dioxygenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0019441 - tryptophan catabolic process to
                     kynurenine [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015272.5"
                     /locus_tag="TL08_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18530"
                     /product="tryptophan 2,3-dioxygenase family protein"
                     /protein_id="WP_084643235.1"
                     /transl_table=11
                     /translation="MTAMTYPRYLHLAELLSLQHPLTAPLEQDLHDNERLFISVHQMSE
                     LLLSQVLVDLRHIKENRCTARCFAHRADRATLMVESLEAHLTLLRETLRPEAFLMFRDR
                     FGSASGLQSAQFQELFRLTDRLETRESSLPLEPHRLARLRTAITHWRRTHLGLVKYMIG
                     DLPGSGDTDGVRFLAKRLAGSSLDDTARHPRTDSEKVRSEHGVS"
     gene            18806..20185
                     /locus_tag="TL08_RS18310"
                     /old_locus_tag="TL08_18535"
     CDS             18806..20185
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673270.1"
                     /locus_tag="TL08_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18535"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_069850719.1"
                     /transl_table=11
                     /translation="MSTVSPDPSFGHVVVAGGSVSGLLAALVLSRHADRVTVLERDHYP
                     GGPEPRSGVPQSRHTHVLLTSGIQALDELLPGVVDELRAADAPYLSVPADVGVWQAGQW
                     VSRDHPSQPVMSASRPLLEQLVRRRVLAAPRIRVWTSTAVTGLLGRADQVTGVTVRDRG
                     TDQQSERAIEADLVVDATGRASRFDEWLAGLGGAPVAEETLETGRAYATCVFHADEQHF
                     DRQLRGFYIVPEAAQTLGAIILPAEGDRWMATLSGPRGQAPPTDPAGFVDFARDLPHQA
                     PHTFLRSARPIGKPVGYRHTGNRRRRYDQGRDRRGLLVVGDAACAFNPVYGQGVSVAAM
                     NATALERLLTGTRVLPSTHRMQRVILRSSQAAWEIATGADSHMPGAEGNAARTGPLDLL
                     LNRYLDRVRDRVPGDPVVCRAFRDVLFLLAPPSSLLTSYQVVRRSLLHPVAAPRSDVLT
                     P"
     misc_feature    19166..19168
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20281..21297
                     /locus_tag="TL08_RS18315"
                     /old_locus_tag="TL08_18540"
     CDS             20281..21297
                     /EC_number="2.5.1.-"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673269.1"
                     /locus_tag="TL08_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18540"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_069850721.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.8e-60, bitscore:
                     201.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATRILPSALTSGVALVEPALREAVGRLCPQMSVVGRYHHGWAD
                     AQGREIDGWGGKLLRPTLAILSARAAGAEPSAGVPAGVAIELVHNFSLLHDDIMDGDTE
                     RRGRATAWTLFGVPRAILAGDALLTAAATELLAAEASGARTATASLMAATQRMIRGQAS
                     DMDFEGRTDVSRDECLRMAADKTGALLACACSLGADLVDADRTLVARLADFGEHVGLAF
                     QFIDDLLGIWGDPARTGKAAGADLHSRKKSLPVVAALNAPDSAELRALYLRPEPLSNDE
                     VARAADLVERGGGRDWARAEADRHVAAATESLEACDIPDAVRGDFLEVAAFITGRRF"
     gene            complement(21475..22410)
                     /locus_tag="TL08_RS18320"
                     /old_locus_tag="TL08_18545"
     CDS             complement(21475..22410)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673268.1"
                     /locus_tag="TL08_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18545"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_084643236.1"
                     /transl_table=11
                     /translation="MSDSGRTQVRWRRSEAVPVDLAPIGLERVRLTPLQQAAATSPQPR
                     RGGRPDAEAGPDDSGDAAKSGGGPLRRSLAVLEELAAASGPLTLSELSELVNLPKSTLH
                     RQMRVLTELGLADRRESKSYELGSYIFQLAASNGPDRVRNISEELTPFLLDLFQTTRLV
                     VSVGALSGLEVWHTGILYRRDHRRIAAAWREPVPAFGSAAGRLLLARSVSDPSELCGIV
                     PTGQTGWNPARAKVLRREFDSIRRTGLSWSRSDAIPGLVEVAAPIHLGNQYPVAAIVLC
                     GMANELDLRKIGGVLLDSVGGIETNLSMAR"
     misc_feature    complement(22543..22556)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.93"
                     /tool="antismash"
     misc_feature    complement(22545..22554)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     gene            23126..23953
                     /locus_tag="TL08_RS18325"
                     /old_locus_tag="TL08_18550"
     CDS             23126..23953
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223525.1"
                     /locus_tag="TL08_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18550"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_069850723.1"
                     /transl_table=11
                     /translation="MTIWICATCGVEHPDSERPPNSDCLICADDRQWVPESGQVWTTLA
                     ELAAQDHRLVHEELEPGLHRINREPGLGIGQRTYLVQTEQGNLMWDPPNHLDETTVRQV
                     AALGGVSVIVASHPHMFGSQVSWSERFDAAPILVHSADRRWVRRESPAIREWSGVTEVL
                     PGVTLVTAGGHFPGSAVAHLAHGSEGRGSLLVGDTIMPVLDSGWVTFERSYPNRIPLSP
                     AIVARIVDRLAPYPFERLYALTGGRVLADAKNAVHRSAQRYIDWVGGKYDHLC"
     gene            complement(23997..24140)
                     /locus_tag="TL08_RS28350"
     CDS             complement(23997..24140)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TL08_RS28350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216637747.1"
                     /transl_table=11
                     /translation="MLHRHHSSVSRRLDQLGPLPSLGIELTEPAGLLRASIALAVWWLL
                     DD"
     misc_feature    complement(24045..24047)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(24084..24086)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(24216..25589)
                     /locus_tag="TL08_RS18330"
                     /old_locus_tag="TL08_18555"
     CDS             complement(24216..25589)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020634222.1"
                     /locus_tag="TL08_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18555"
                     /product="cytochrome P450"
                     /protein_id="WP_069850725.1"
                     /transl_table=11
                     /translation="MTADSAHAAAAAQPRCPAHAARIPLHGAEFSQDPARFYADLREHG
                     PVAKVELAPGVPASLVTDYSAALTVLRDPISFPRDPHHWQRSLPPTASMIAAMAFQPLC
                     LIVDDSAHARLRGAMSDGLDRVDPTLLRASVERSADLLIDEFIGAGRAELLADYAAVLP
                     TLVLAQLYGASAGLGKRLMAGAVRAKNRSPHRTAVDLHESVSELVAYKRARRGTDVTSA
                     MLDHPAELTDEEVVDQLTALGYGVEPLQNWITNSLRLLLSDERFAGAVSGSVVVEDVLT
                     EVLWADPPIANHAPMFPVRDVEVQGVPLPAHQPVLISFAAANTDPELAVGQERAGNRAH
                     LAFGAGPHSCPAQAPARVIATVGIERLLDRLPDLELAVPADRLTWRPGPYHRALAGLPV
                     RFTAVGARSTSDRSTPRAPEPDTVHLPRPTARPTPSESDGEETGPAWWQSLTRWWRDR"
     gene            complement(26023..26706)
                     /locus_tag="TL08_RS18335"
                     /old_locus_tag="TL08_18560"
     CDS             complement(26023..26706)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037008.5"
                     /locus_tag="TL08_RS18335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18560"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069850727.1"
                     /transl_table=11
                     /translation="MTAVDTDSAQRRRSGVRRERAEVTREHLLHTAERLFAERGLSEVS
                     SRQIVEAAGQANNSALAYHVGTRADLLRAISRAHVEPITRRSRELFDETRGSSDPGEYL
                     GCLVRPYTEHLASLGTPSWYARFAAQLATDPAYVGVVLWAPELAALLEDAHHAMSAHVP
                     DLPSELTRLRYQTARLAVLHTCAEQERAAADTGVPADWELIGDALTDGITGMLLAPVRP
                     RPHQG"
     gene            complement(26711..27979)
                     /locus_tag="TL08_RS18340"
                     /old_locus_tag="TL08_18565"
     CDS             complement(26711..27979)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646376.1"
                     /locus_tag="TL08_RS18340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18565"
                     /product="cytochrome P450"
                     /protein_id="WP_084643237.1"
                     /sec_met_domain="p450 (E-value: 1e-18, bitscore: 65.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGDETATDDETATATTCPIGPDAAPGGAAEALPFPFALPTALEP
                     PEEWSQLRDECPVARVRTVVGEDALLLTRYDDVRQILADPRFTRKPVPTEDSANDEPLS
                     VPASIANGEGHLRWRRLLSRSFTVKRMTALQPRITTIAHELIDAMVAQGPTSDLRSALG
                     FPLPVYVICELLGVPAADRERFAHWSDHMLNLTRYTQAEVQTAGRELWAYLTAHVRAKR
                     AEPGDDLLSELTAIADEQDGRLSEAELILSGQALLIAGHETTANMIGKMVAMLLSKRER
                     WEQLLADPSLVKSAVEEVLRFDANLGSSGMHRHISEPVEVGGTTIEAGTTVLALMQAAN
                     RDERAFAAADEMDLTRSPNPHLTFGAGPHSCLGQALARIELTTVLGVLLERLPGLELAI
                     PAEELRRREGLLVGGLEEVPVRW"
     gene            complement(28201..29682)
                     /locus_tag="TL08_RS18345"
                     /old_locus_tag="TL08_18570"
     CDS             complement(28201..29682)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (87-264). E-value:
                     6.3e-16. Score: 50.6. Matches aSDomain:
                     nrpspksdomains_TL08_RS18345_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672421.1"
                     /locus_tag="TL08_RS18345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18570"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_069850729.1"
                     /sec_met_domain="PF00561 (E-value: 2.5e-19, bitscore: 68.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRTSAFALVAVVAACVVPGVAQAATSQQASPTPAPLQWGECPAD
                     SGVTTLECATLDVPLDYQDPTGRQIEIMISRLASDNQEQRRGVLLTNPGGPGASGLNFP
                     TDLKDAGLPQSVLDSYDIIGIDPRGVGQSTPVTCDLSLEQQLMGNLPPYAHNAEDVVER
                     AVEVELVAEQCATSETAWMLPHTTTANAARDLDMVRQALGEETASFLGYSYGTHLGAVY
                     TTLFPETSDRVVIDSSLPPNGLDHEAGKLMGPGFEERFPDFAAYAAARPELGLGNTPDE
                     VRAKYFEIAERLDEEPTTELTGALFRIATLSNLARDSHFPTLVELWQQAEAGRPVSVAS
                     NPLTLSDTDDLGFDNPLSSHLYVLCGDNEWSRSIESYQDDVEAARKPYPMYGPAAANIR
                     ACAFWPEIDRAPVEVDDQGPSNVLLVQNTRDASTPLIGAQQMRDALGDRVRMVTADQGG
                     HGVYLFGTNACANDSVTDYLVTGERVSEDRFCAAE"
     aSDomain        complement(28891..29421)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TL08_RS18345_Abhydrolase_1.1"
                     /evalue="6.30E-16"
                     /label="TL08_RS18345_Abhydrolase_1.1"
                     /locus_tag="TL08_RS18345"
                     /protein_end="264"
                     /protein_start="87"
                     /score="50.6"
                     /tool="antismash"
                     /translation="VLLTNPGGPGASGLNFPTDLKDAGLPQSVLDSYDIIGIDPRGVGQ
                     STPVTCDLSLEQQLMGNLPPYAHNAEDVVERAVEVELVAEQCATSETAWMLPHTTTANA
                     ARDLDMVRQALGEETASFLGYSYGTHLGAVYTTLFPETSDRVVIDSSLPPNGLDHEAGK
                     LMGPGFEERFPDFA"
     gene            30091..30858
                     /locus_tag="TL08_RS18350"
                     /old_locus_tag="TL08_18575"
     CDS             30091..30858
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010240932.1"
                     /locus_tag="TL08_RS18350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_18575"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_084643238.1"
                     /transl_table=11
                     /translation="MRSSELANLAGVTVRALRHYHKIGLLDEPERSLNGYRTYDVRHLV
                     RLLRITRLTGLGVPLAVLPEVLDDPEATEVLLDELDKNAATEIERLQGRRKAIAGLRSN
                     GMTPDLPPAMAAYLPVYTAIAEVDPELARYEREQFMLIGQVIGETALATFADYVARRFT
                     FDPDSMTLLRRFASLGPDSTESTMAELADEMALHYQRTFDAPLGITMDRQLIPILTAHV
                     EHVLNEQQVHTNRLMNERFVELARQQQAIRATS"
     misc_feature    30361..30363
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    30604..30606
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 cagctccgag gcagcgttgg tcgggatcag gttctccaac agccgggaga caccggtcca
       61 ggcatcgccg accaggtcct cctcgacctg tccgccatgg acgatgttga ggaagttctc
      121 catccgacgg cgttgccagc ccggcgtgag cgactcgacc caggccgggt cggtgcgccc
      181 gttgtcacgc acgtcgaccg tggagggcgt gcgctggaag acgtacagct gttccgcgtc
      241 gcgacccaga tgcggcacca cctggatcgc ggtggcaccg gtgccgatca gcgcgacccg
      301 cttgtcggcg agccgatcca gcccgccgtc ggcgctgccg ccggtgtacc cgtagtccca
      361 ccggctggtg tggaaggtgt ggcccgcgaa gtcctcgatg ccggggatgc ccgggagctt
      421 gggcttgctc aacgttccgc tggacaccac cacatgccgg gcccgcatca cgtcgtcgcg
      481 gttggtccgg acgatccact ccgaggcctc gtcgtcccac cggagttcgg tgaccctggt
      541 ctggaagcag acatcgcggt acagctcgaa gtgccgggcg atggcgcgcg cgtgctgccg
      601 gatctcctcg ccgggcgagt acttccactc ggggatgtac ccgatctcct ccagcaacgg
      661 caggtacacg taggactcga tgtcgcagtg gatacccgga tagcgattcc agtaccaggt
      721 gccgccgaag tcccccgcct cctcgaccat ccggatgtcg gtctgcccgg cctgccgtag
      781 gcgagcgccg gtcagcaggc caccgaagcc gccgccgacg atcagcacct cgacgcggtc
      841 ggtcagcggt tcccggctga tcgtggtttc caggtacgga tcggcggcgt agtagccgaa
      901 ttcgccctcg gtgcggcggt actgcgcggc gccgtcgggg cggatccgcc gctctcgctc
      961 ggcgcgatac ctggcgcgta actcgtccgc gtcgaagtcg agctgctccg cgagcggttc
     1021 gggagatgac gagtggatcg acatgcatgc ctctctgttg tgcgactgca tcgagagatc
     1081 ccgtgcagcc catgggccgg aagagcgatc ggcatccggt gagatcggta ctgctcgagc
     1141 ggtgtccagg caggcgaggt tcgctcggtc gggtcgttgt ccgccgaaat cggcctgcat
     1201 agcgctaccg ggattgcggc tgctccacgg tcgatccacc gggaactccg gtgtgcacag
     1261 cgatcgacgc gcgctaccgg gtcagcgacc gccggtgggt ctgacgacga gggattccgc
     1321 tctggccaac gcggataacg agtggtccgc ctcgtgatcg gcatgccgca cgccgttacc
     1381 gccgccccgt cgaccgctca tgattccagc taagcaccgg ccatcgaatg agtcaatcga
     1441 ctgacttaat agtcgctggt cgggctcatc ggtgatgtcg gtcatagccg agatcgagtg
     1501 ggctgccgga gcagactccc cgaccacccc actcggaaac tcggacagct accggctcca
     1561 tggcctgcag atcgatcgac gtcgcaggct tgccacgccg cgcggtcact cctccgtggc
     1621 gggcagcggc tcgcccgaca tcgcgcagac ggccccgtcg atcagcgccc gttcggccgc
     1681 gccgagtgct tcggtacgca gaccgaactg cgtcgtcgtg accacggtga ccgatcgggt
     1741 acccgactcg tcgacgtagt tcgcactggc atagccggga ataccaccgg tgtggcccca
     1801 caccgagccg cacgggctct gatactgctc caggcccaac ccgtatcggg cgctcgcagg
     1861 ctcgccggga aactcgacga ccgtctcctt catctcggcc agctgcgcgg gcggcaggac
     1921 cgaaccggac aacagcgcac ggaggaaccg ctgccagtcg gagggcgtcg agaccaccgc
     1981 gcccgcagtc caggaccagg acggatcgat cgaggacacc tcgacgtgat cgtcgcgcgg
     2041 ctcccccacg aaggcgacgc cctcgggagt acccggcggc agcaatggcg cgagatgctc
     2101 ggcatcgggt tcgtagccct cggccagtag gtcaccatcg cgagactcgc cgtcggtggc
     2161 cagatacgtg tcggtcaatg ccaatggatc gaggatccgc tgctggagaa gatccgccac
     2221 ctgctgttcg gtcgcccgtt ccaacaccat gcccagcgcg atgtagttgg cattgctgta
     2281 ggcataggcg gtgcccggag cggccagggc gggaagttcc accgccgctt ccagcaggcg
     2341 agcgggtggc aacggcgtcg tgctgttgcc ggtgatcaaa cccaggacct cgggatgaag
     2401 aacgtaatca tcgagtccgc tggtgtggtt caacagcatc cgcagggtga tctcgtcgcc
     2461 gttcgggata gcggcgggca accatttctc caccgtgtcc gacagggaga gcgtgccgtc
     2521 ggcgacctgc tgcaacgtga gcacgccgat catggtcttg gtgttcgaac ccatgcggaa
     2581 ctgatcctga accgagagcc gctgttcgac ccaaccggcc tgtccggtca gctcgatcgg
     2641 ctcgcccgca ccgtcgtcga ccagtgccac cacgccgggt gcgcccgcgt cgacgagctc
     2701 gtccagcagg acacccaatt ccggtgtcgg agtatcggcc gcgccgctgt gctgggctgc
     2761 cacgtcaccg ctcggtgtgg cggacggcat gcccgtatcg gcagtgcctg cgcaggccgt
     2821 gaccaaggcg agcaccgtca aggtccctgc gacggtcgca gtggcccgtc gtgtggagcg
     2881 agtcgttccg gcataccgga tattcatggg tttctcccgg gaatcagagc ctgctacggc
     2941 gaactcaccg catgagactc attcagccag gatcggccgc ccagaacgtc gcaccttcga
     3001 cggctttgga ccgtcgccga gtcactccga ggaatgacac cggtcgacgc gctctcgcac
     3061 tgtcgaccgg ctgacggtca gcctcctacc ggtcaggaca gcgtgttcct ggccaacacc
     3121 gccgcctggg ctcggctctg gcaaccggtc ttggcgagca tgcgactgac atgggtcttc
     3181 accgtgtgga gactgaccac gagccgctcg gcgatctcgg cgttgctcaa cccgtcgccg
     3241 acgagccgca gtacgagccg ctcgcgggcg gtgagtccgg ccagtcgagc gagttcaccg
     3301 ttgtccggtc gatgccgggc ggcgaggtga ccctcgatga tgcggcgggt cacgaccgga
     3361 ctcagcgcac tgtggccgag tgcggcggct cggacagcgg cggtcagttc ctcgtaggaa
     3421 ctgctcttga gtaggaaacc cgccgccccg gctgccagcg cctcgtcgac gtactcgtcg
     3481 aggtcgaagg tggtcagcat gagcacccgg gtcttcccgg ggccgaccag cccgcgcctg
     3541 cccagttcgg tcagcgccca cagcccatct cgacggggca tccgaatatc caagagcagg
     3601 acgtcgggtt tgagttgggt gcacacgtcg atggccgctt cgccgtcggc cgcggtaccg
     3661 gcgacgacga ggtcggcttg ggcgtccagg atggtggtca ggccgatgcg gacgagctgc
     3721 tcgtcgtcca ccacgaccac cgtgatctgc tcagccaccg actactcccg agggcagggt
     3781 ggcggtgatg cggaatccgc cgtcggaggt cggacccacc acgagctcgc ccgccagcgc
     3841 atcgacccgc tcgcgcatgc tgatcaggcc gagaccggct cccgcgcctt gcgtgcctgc
     3901 tcgtaccgcc ggacgattca ccacgtcgat cagcattccg gcggcatccg actccagcgt
     3961 cagcaccacc ggggcgcccg gggcatggcg gcgggcattg gtcaacgatt cctgcacgat
     4021 gcggtagccc gccagctgcg tcggacgtgg caacgactcc agctcgcccc ggagtcgcgc
     4081 ttcgacggtc ccgccctcgg cccggtggcc atccagcagc gccggtagat caccgagatc
     4141 cggcatcgga cgcagcggga cggcgtcggc gggatcacgc aacatacgca acaggtcgtg
     4201 cagttcgccg ctgatctgcc tgccggccac ggcaagcccg tcggactggg ttctggccca
     4261 atccggcaac tcggcgctcc gagaacgcag cgcctcggcg tgcacgatca ggagggtgag
     4321 cgaatgcgcg accaggtcgt gcatctcgcg tgcgatgcgg acccgttcct gctgggcggc
     4381 ctgctcggcc cgcaggtgtt gctcgcgggt cgcatccgcc gcccgctgtt cggccgcgac
     4441 gagcaacaca cgtctgcttc tggctccgaa accgagtgcc caggccaacg gcatcggtgc
     4501 cagcactgcc aacacgtccg gaccgcctcg gaaatcgact gcgctcaccg tcatccagtt
     4561 gatccacagg cctatcccga ccatcaggcc gccgaccagg gccgccactc cgttacgggc
     4621 ggggcgggca ccgtggttgc ccaggttgta caggacgacc gcgagcgaga ggaacgccag
     4681 cggtgacaac ctcgctccca ctgccgcgcc tgccacgatc gtcgcaacca gcgctgcgac
     4741 gatcacgagg aaggcggtga tcggcatccg acgtcgcacc accaaggccg ccaaggccac
     4801 cgcctcgaaa cacgccagta acagccacgc ggtcgccgtg gagtcggtgc tcggctgtag
     4861 caacgcaggc gccaacaggg tcagcgcgat gagtccggca tccgcaatcc attcgcgcct
     4921 tcggcggagc tgttctgtca ccactcgacc ctaggaccgc cgagtcctcc gatcgtcact
     4981 ccttgggact agaccggctg atccgaatac gcgcttcgga cccaagcgag aacagcgcag
     5041 ccgtcgcggt tcgctcgtcg gcggagcggc ggggcggcga cgcggcgggt gaccattccc
     5101 gcccatatct cgcgcactct agcgagatcc acaccgaatc gcacggctgt tctggaaatc
     5161 ggaaccatgc gttgagcccc gcgccgattg atccttacgg tgctggatat gggtgacacg
     5221 agtacagacg agcagacgaa ggccgcaggc acacgtcgca tcctgttggc cggtccccga
     5281 tccttctgcg caggagtcga gcgagccatc gagatcgtcg aacgcgccct gcgctcgcac
     5341 cccggaccga tctacgtccg caagcagatc gtgcacaaca tctcggtcgt ggaggacttc
     5401 acccgacgtg gcgtgatctt cgtcgaggaa ctcgacgagg tgccgaacgg ctcgacggtg
     5461 gtgttctccg cgcacggcgt ctcccccgcg gttcgcgagg atgccgcccg tcgacaactc
     5521 gatgtcatcg acggcacctg cccgttggtc accaaggtgc atgccaaggc ccgtcgcttc
     5581 gccgcccggg gcgacacggt ggtgctcatc gggcacggcg gtcacgagga ggtcgaggga
     5641 accctcggcg aggcacccga gtccatcgtg ctggtcgaga cgctggagga cgtgcagaac
     5701 ctcgagatcc ccgaccccga gcgggcctcc tacctgacgc agaccacgct ggccgtcgac
     5761 gacacggccg agttcatcgg cgcgcttcgg cagcggttcc cgttgttgca cgagccgtcc
     5821 tccgaggaca tctgctacgc caccaccaac cgccagcacg ccctcggcgc gatcgtcgac
     5881 gagtcggagc tggtgctggt cgtcggctcc acgaactcct cgaactcggt gcgtctggtc
     5941 gagttgtcgc gcaggcaggg cacacccgcc tacctcatcg actcgtcgaa ggacatccag
     6001 cccgaatggt tggacggcgt gacgacgatc gggttaaccg caggcgcctc ggctcccccc
     6061 gcgttggtcg acgaggtggt gggtgcgctg cgggaactgg gaccggtatc ggtggaggaa
     6121 cgcgagatca gccgggagac cacccacttc gagcttcccg ccgcagttcg ggatctgccg
     6181 gatcgcgcgc agtagcccga cggcggaatc cgcccacccg caccacgtcc caccgtctcg
     6241 gtcgggcccc atcccggact cgacatgtca tcggaccgcg agagatccgt ggtcgacagc
     6301 agtcggacag gcagaagtag tcggcgcgcg gcaccctaca tctgaacggc gtgagacatg
     6361 acaaccacca cattgctcag ccatatcacc agcccgcagc gcctcaaaga gctcccaccg
     6421 gagcggcttg gcacgctggc gaccgagatc agagagttcc tcatcgacaa ggtctgccgg
     6481 gcaggtgggc atctcggtcc gaatctgggc gtggtcgagt tgaccatcgc gctgcaccgg
     6541 gtgttcgact cgccgaccga ccgcatcgtc ttcgacaccg gccatcagtc ctacgtgcac
     6601 aagatcctca ccgggcggca cgacgacttc gactcgctgc gcacggcggg cgggttgtcc
     6661 ggctatccga accaggccga gtcgccgcac gaccacgtcg agaactcgca tgcctcgacc
     6721 gcgctgtcct atgccgacgg cctggccagg gcggtccggt tgcgcggcga ggacagccgg
     6781 gtggtcgccg tcatcggtga cggtgcgctg accggcggtc tggcctggga ggcgatgaac
     6841 aacctcggtc gcggcgagca tcccgtggtg atcgtgctca acgacaacgg tcgctcctat
     6901 gagcccacgg tgggcggcct cgccgatcac ctcgccgaac tgcggcgacc gggatcgacc
     6961 ggacgaaacc tgttcgagga cgtcggcctg gcctatctcg gtccggtgga cggccacgac
     7021 accgccgccg tagaggaggc gtgtcggcag gccgtgcggc tgtgcaggcc cgtggtcgtc
     7081 cactgtgtca ccgagaaggg ccggggctac tcccacgccg agcaggatgt ggccgaccac
     7141 atgcacggaa tcggcgtcat cgacccggag accggccggt cgagccggaa atccgcgccg
     7201 acctggactg cggtcttcgg ccaggagatg gccgcgatcg gcgcgacgca tcccgaggtg
     7261 gtggcgctga ccgccgcgat gctgcgtccc gtcgggttgc acgcgttcgc gcaacgcttc
     7321 cccgatcgca tcgtggacgt gggaatcgcc gagcaacacg cgatgaccag cgcggcgggc
     7381 ttggccatgg gcggcctgca tccggtggtc tgcctgtacg cgaccttcct caaccgcgcc
     7441 atcgaccagg tgttgatgga catcgccctg caccggctgc cggtcaccat cgtcctggac
     7501 cgggcgggcg tcaccggacc ggacggcgcc agccaccacg gcatgtggga tctcgcgctg
     7561 ctcagtgcgg tgcccgggat gcgcgtcgcg gcaccgcgcg actccgtgca gctcgcgaga
     7621 caactgagcg aggcggtggc gatcaccgac ggcccgaccg cgctgcgatt cccgaaggcc
     7681 gccgcagggg acgagatcgc tgccgtcggc acgatggacg gactcgacat cctgcaccgg
     7741 agccggtcgc tgccgctgga cgtgctgctg gtgtgtaccg gggtgctggc cggtccggcg
     7801 aaacatgctg cggagtcgat cgccgaggac ggcatcgggg tgaccgtggt cgatccccgg
     7861 tggctgctgc cggtgaatcc cacgctcgtc cacctggcct cccggcatcg ggtggtactc
     7921 accgtcgagg acgggatgcg ggtcggcggc ttcggttccg cagtcgccca ggcctgttcg
     7981 gatgcgcggg tgtccgcccc ggtgcgcaat ctcggactgc cgcgcgagtt cctcgatcac
     8041 ggaagccgcg gcgccatcct cgccgagcac ggcctcaccg ccgagtccat cgccgcaacg
     8101 gcgagagcgc tgctcgaagc ctccaccgaa ggccagacca ctccgttcga agggatactg
     8161 cggtgacctc cgtcgcattg ggaatgccca cgctgccacc acccgtgctc gcccctcggc
     8221 ggcagacccg ccaactccag gtcggttccg tcggcgtcgg cagtcagcac cccgtctcgg
     8281 tgcagtcgat gacgacgacg gtgactgctg atgtgaatgc gacgttgcag cagattgcgg
     8341 agttgacggc gtcggggtgt gacatcgtgc gggtggcgtg tccgacgcag gatgatgcgg
     8401 atgcgttggc cacgattgcg gcgaagtcgc agattccggt gatcgccgat attcatttcc
     8461 agccgaagta tgtgttcgcc gcgatcgagg cggggtgtgc ggcggtgcgg gtgaatccgg
     8521 gcaatatcaa gaagttcgat gacaaggtca aagagatcgc ccacgccgcc cgcgaccata
     8581 agactccgat ccggatcggg gtgaatgccg gatccctgga tccgcgtctg ttggccaagc
     8641 acggcaaggc caccccagag gccctggtcg agtcggcgtt gtgggaggcg tcgctgttcg
     8701 cggagcacga cttccacgac atcaagatct cggtgaagca caacgatccg gtcgtgatgg
     8761 tccgcgctta cgagttgctg tcggaggcct gtgactatcc gttgcatctg ggggtcaccg
     8821 aggcgggtcc ggcgttccag ggcacgatca aatccgccgt cgcgttcggg gcgttgttgc
     8881 ggcagggcat cggggacacc atccgggtgt cgctgtcggc gccgccggtg gaggagatca
     8941 aggtcggcac ccagatcctg caatccctca acctgcgacc gaggaaactc gagatcgtgt
     9001 cgtgtccgtc ctgcggccgc gcccaggtcg atgtgtacac cttggccgag gaggtcaccg
     9061 cggggttgga gggcatggag gtcccgctgc gtgtcgcggt gatgggctgc gtggtcaacg
     9121 gacccggcga ggcacgcgaa gccgacctcg gagtggcctc gggtaacggc aagggccaga
     9181 tcttcgtcaa gggcaaggtc atcaagaccg tccccgaaca ccagatcgtg gaaaccctca
     9241 tcgacgaagc catgcgcatc gccgaggaga ccgaggccgc aggcgaggac gccgaggcga
     9301 tcgccggtgg cacgggcccg gtggtcagcg tcgttggggg gcagccgttg tgagctccgt
     9361 aagagtgctc gtgctggcct ccgatccgct ctcccggatg gcgatcgtcg gccacctcga
     9421 tgcacagccc aggatcgagg tggtcgccgt cgagcagcag cagcgggcag gcctcgacgt
     9481 gatcgtgttc gtcgccgacc gagtcaacgt cgaggcactg ggacgcctcc gccggatgaa
     9541 ggcgatcctg tccgcgccgg tggtgctcgt caccggagag atcggcagcg ccgacgtgtt
     9601 caccgtcgtg gagtccaacg tcgtcgcggt gcttccccga cagaccatca ccgggccgca
     9661 gatcgaggaa gcggtgctga cggccgccgc cgggggcggg atgctgccct cggcgatgct
     9721 cggcgaacta ctcaagcagg tcaagcgact gcaacacgag gtgctgctgc cgcacggtct
     9781 gcacgcctcc ggcctcaacg ccagggagat cgaggtcctc cggctgatgt cggacggcct
     9841 ggacacggcg gagatcgccg tcaaactcgg ttactcggaa cggctggtca agcgggtcat
     9901 ctccacggtg accagtcgac tggggctgca caatcggccg cacgcggtgg cctacgccct
     9961 gcgtaagggc gtcatctagc gcagccccgg tcgacccggg tcatcgcgtc gcgggttcct
    10021 ccacggcatg ggggcgtgtt cgccaagccc acggcgaacg cccctccgcc cgcatcctcc
    10081 ggtgcagcaa caccacgtag aggatgtcca gggcgaccat ggtcggcacg atcacgaaga
    10141 acagcagccg tgacgggtac aggatgaaac cggtcaggcc cgcgaagaag gagccgccca
    10201 gcttcgccac ggccaggtac atcgactgcc cgatcgaact gccgcgccgc cggagcatga
    10261 agatgaaggc ggcgctcaac gggacgttga ggatcatccc gatgtacatg ccgtcccggt
    10321 cgtggaactc gttggcgccc gccatgatca gtaaggcggc ccagacgaag acgccgacca
    10381 gcgaccaggc gaacgccttc tgagtcagcg tcggatagtc gttgcgcccg tagcggaaga
    10441 ccagactcag caggacgagg ttgaagacca gccacacgag gttgatcccg cgctgcgtgc
    10501 tggtctgttc cagcaggaac gtgaggctga actcccaggc gacgttgatc gccaccaggt
    10561 aggcggggat cgcgacccgc ccgtccaaca cggtctgtcg gatggccagt aggtaggtga
    10621 tgagccaacc gagcacggtg gggcccgcga cggaccagaa cagccagtcc ggcacgtcgg
    10681 ccggaccgac cgtcacgggc gcgatctccg acatcgggaa caacggtggg ggaagccaat
    10741 ccaggtccac ggcacacgtc ctcagcgggg tcgacggggg gaagcggaga cagggcggaa
    10801 cagggcattc ctggtggctg cggcaggcag gcgatcgata ccggcctgcc acagccgcct
    10861 cgatcagaga cctcggacga tcagatccag tccgaagaac gcgccgccgt agagctcgcg
    10921 accgatatgc acgttgagca tggcgtgccg cgccgcggta ttggcgtcac gccagtactg
    10981 ctgcagggga ttggactccg cgaaggacgc cgcgccatgc gcccacaaca gctcgttgag
    11041 tgcgatggtc accaggttca ccgcgtggcc gacgtcgcct cggatgcgcc ggagttccgt
    11101 ctccggcagg gcgacggcgg cctcggcggc cgcgtcgatc acgtcggcgg cccggctgac
    11161 gtgcagctgg gcggagtcga gggtcagcgc ggtcccaccg agcccggaca cgaaggtcgg
    11221 cgagctggtc tggttggcgt acagactcgg cgcgatcccc ctggaggggg cccggtccac
    11281 gacgaggtcg agggcggcct gcccgatgcc gaccaccacc gaggcgcaga tgacggccat
    11341 cgcggccacc gcaggcgtgc ggaacaacgg agtcagcgag acgtcctcgg cgttctgccg
    11401 tccgagctgc cggtccaccg ggatgatccg atggtccgga acgaacacct cggtggccac
    11461 ggcggtgtga ctgccggtgg cgcgcatccc gacggtggcc caggtgtcgt cgacggtgag
    11521 gtcggcgacg ggcaccagca ccgataccgg tcggatcagc tcgccatcgg cgtcgatctc
    11581 cttggcgctc aacaccgccc agtcgtcgtg caggatgccc gaggcgtacg gccaccgccc
    11641 cgacagcagg caaccgccgt cggtgcgcac cgcatcgcct gcggccacga agatcgaggc
    11701 cagtttggca ccggggtcgg cgccgaacac ctcgtcgcgg gcctgctgtc cgaaccgcga
    11761 ggccatcagg ttggagccgt tgatgttgtt gaccacccac gaggtggacg gacagtagtg
    11821 cgacagggcc ttggtgacct cgctcagggt ccgcacgtcg gtctccagcc cgccgtagga
    11881 ccgggcggtc cagagcatgc cgacctggga ttcctcgatc gcctgcaggg tggcctgggg
    11941 gagtcggcgt tcccggtcgc cctcggcgac gccggccgcc agtaccggac cgatcgcgtg
    12001 gacacggtcc agcagctccg aacgcagatt caccggatct gttcgcagat gggtcatgag
    12061 gtgccctccc ggggcgctga agcgcggccg ggtcggcccg atcgcgcgcg tgagttgcgg
    12121 acacagcaga caggcgattc ggtggcgatc gcccgattcg tcggcgggcg ccgggtggcc
    12181 gtggggtgat cgtcgacgcg aacgcagccg atgcggcgga tgcgccgtcc gggcaggcgg
    12241 atcgtcgacg atcccccacg aatcagccgg ccgtgtcctc cgattcggag atgaggcggg
    12301 tgatgtcgaa gtagtcccgc caggcactga tccggccgtc gcgcagctcg aaggccgccg
    12361 ccaccttcag attcgccgcg atcggtgtgc cgtctgtccg cagcatgtcc tcgacccgtt
    12421 cgaccagcac ggtgtcgccg gtgaccgcca cgcttcggaa gcggaccacc aactgcgcga
    12481 acgcgggtgg catcagcgcc atgatctgct cccggcctcg gcagaccggg gaaccggggt
    12541 tctcccagac gcagtcctcg gtgaggaacc ggtccaccgc ggccccgata tcggcgggcg
    12601 tcgggcccat cgcgccgagg aagtcccgga cgacgcgctc gttgtcgatg ctcaccgcgt
    12661 cagcctccgc tcgccacgag ggcgggcttg ccgaggatcc gggcgaagac ctcggtgagt
    12721 tccgaggcgg gcgaggtgcc cgcgcgctcg gtgcgccagg cgacgtggtt gtccggccgc
    12781 accagtaccg cgccctcgcc ggggacctgc cgcagcgccg cccagccgcc gtcgacgtcc
    12841 tggtagtcgg cggattccgt cccgaccgag acgacctgca acgccacccc gtgagtcgcg
    12901 gcgacccgct cggccgcgtc cacccacgcg gagttctccg gcccggtgat cagcacgaat
    12961 ccaccgtggg cgccgacgag atcgtgggag gagacgcgtt cgccgtcctt gcgcaaccac
    13021 acgtgcggca accggtgtcc cgggcgggtg accgggtggt atcggccgcc catcgggtcg
    13081 cgcggcggcg gctgggactc gtcggcgacc agggcgccgg ccgcatagga gaagccgatc
    13141 tcgatgtcgt gcgcctgata ctccacccgc tgcgtggtga agacctcgtg cgcgcggatc
    13201 cgacgggtct cccccatcgg cgtgtcggag aagagctcca ggaagttgcg ctgggtggcc
    13261 tccaacggtt gcccgggcag caacccgagg cctgcgtgcg ccacggcgtg gttgcgcagc
    13321 gcgtacatcg cccagctcac gttccgatgc gcgaccggca ggcgttcctg ctcgaaggtg
    13381 tccagcagcg cgtcgtcggc ctgcccgtcg agtaccgccg ccagcttcca ggcgaggttg
    13441 tgcgcgtcct ggatggccga gttgaggccg agaccggtcg cgggcggctg ccggtgtgcg
    13501 gcgtccccgg cgaggaagac ccggccgacg cggaaggtgt cggcgatgac cgcctcgggc
    13561 acgtagtggc tgacctggtg gacggcgacc tcgaggtcgg gcagtttcag cagctcacgc
    13621 acgcgcagca cggccgtctc cgaggagaag tccggcgtgc tgcccaccgg gatgtggtag
    13681 tgcagcgccc aatcctgcga gtgcagtccc cagcctggtc ccacggcgac gatgccgtaa
    13741 cgcgagatcg gtccgccgtc cgggctgacg aagtgggtca tcagcaccga gtcgcccggc
    13801 caggactcgg agagatcggc ggtgaagtgc acggacatca cctggaaggc gccgggctcc
    13861 cctgccatct ccaccccgag cgaggcgccg atgctgcggc caccgtcggc cgccaccagg
    13921 tagcgggccc ggatcgtctg cgactcgccg gtctcccggt cggtcaccac ggcggtcaca
    13981 ccgtcctcgt cctgggtgaa ctcctccatg acgtggttga agcgcacccg gtcaggcgcc
    14041 cgctcgtcgg cgtggcgacg cagcaccggt tccaggttgt gctgcgggaa gttcgtcgac
    14101 gggctggggc tgtcggccgc gtagggaccc gcggtggttc cgccgccgaa ggcgtccatc
    14161 cggtgcaggt ctcggccgtc gagcgggccg tctcccgcca gcgaggtccg ccagacgacc
    14221 tcgctcatgt tctccagcgg gcagctctcg cggtagacgt cctcggcgac gccgtgctgc
    14281 cggaagatct ccatggtgcg ttggttcagg tagtgcgctc tgggcagtac ggaggtggac
    14341 tcgcgtctct cgacgaggag gtgatccacg ccgagatcgg ataagaagag cgaggtggtg
    14401 agcccacagc cgccgccacc gacgataagt accgatactt ccacatcaga cattgatttc
    14461 tcctcgaacg aggtgatcat gcgacgggat ttcggggccc gttcggcggg ccttggcgtg
    14521 cctgttctcc cggtgtcgtg ctcgacactc ggtctatcca caaaggactg atcggtcgta
    14581 ctggtgcccc gggcccgaag ccacctcggg tgtggcgccg ggagctcggg ccgtggcggg
    14641 tcagcggcgt cgggtcgtca tgacgccgag tcgcgtccgc ccgagaggat ggcgttggcg
    14701 gggcacagca gcgccgcctc tcggacctgt tcgtgcaggt gctccggcgg ggccggatcg
    14761 agcaggacga cgacgccgtc ctcgtcacgc tggtcgaaga cctccgccgc gaccatcacg
    14821 cagtgtccgg cggcgacaca cttgccctcg tcaatctcga tcttcatggt caacctcacc
    14881 ctccagccgc gtcaccaggt gacgggcagc ctgttcacgc cgaagacgag cgcggtcgtg
    14941 cggtagtcga tctcgtcgtg gtcgactccc acggccagcg tggggaacct gttgaacagc
    15001 gccggaagcg ccacccgcag ctccagtcgg gccagctgct ggccgaggca ctggtgcgcg
    15061 ccgtagccga acgtgatgtg gggttgcggc ggcctgcgca cgtcgagggt gtccagatcc
    15121 ggggcctcga tgtcggggtc gcggttggcc acgaggatcg aggtcatcac ccgctcgccc
    15181 ttcttgatca cctggtcccg cacctgtagg tcggccgcgg cctgcctggg catggtggtg
    15241 gccggggagc agaaccgcag cagttcctcg atggcgccgt cgatcgccga cgggtcgtcg
    15301 cggaccacgg cgagctgctc ggggtgttgc agcagcaggg cggttccggc cgagagcatg
    15361 ctggcggtgg tctcgtgtcc ggcgatgagc agcatgttgc cgatgcccac cagctcgtcg
    15421 tcggtcagtt cgggaccgtg gtcgcgaacc aggatgccga gcatgttgtc gcccggctcg
    15481 cggcggtgtg ccgcgacgag ctcggccatg taggcgtcga gctcggcgag gttctcgatc
    15541 tgcttctccc gggaggtgtt gatgtccaac ccgaccttgg cgcggcgctg gaagtccgcc
    15601 cggtcggcat agggcactcc gagcaggtgg cagatcacct gggtcgggat gggcgtgctg
    15661 aactcggtga ccaggtcgac gccgggtccc tcggccgcca gtgcgtccag ccgctcggcg
    15721 acgacctcct cgaccatcgg ttgcagggcg cggattcgct tgaccgtgaa cgcggccgtg
    15781 agcatgcggc gcagccggga gtgctcggcg ccgttgtagt tcaacaggtt gcccggctgg
    15841 ttgagcatgg tgcgcggggc gtccgggtcg aagacgaaac ccatctggag ccggtcgtcg
    15901 ttcagcgcgc tgcggatgtc ggagtagcgg gtgagggcga ccgcctcgaa ctcgccgatc
    15961 atcgggttgg gaatgcggat tcggggaagt tcctcggatt tctgcatctc gtagagctcg
    16021 gctgccgggg cataggggca tcccgtggcc cgtgcagcgg tgggtagcac cttgggctcg
    16081 tccatgcgaa cgcctttcgt ccaggggtga cgcgactggc ctcgcccggc ggtgagtacg
    16141 caggcagagg ggagcacaag acgggtcagt cgcacgtcgg gtccacctcg ggcgccgtca
    16201 gctggtcagc cggtgcctcg ccgagcaccg gccgacgatc ggcgtgccgc ccgagtggac
    16261 cgtaacatta aatggcggag tgtgccattt tgtcttagcg cgccatgaat tgatccgaga
    16321 cgggccaacc gggccaggcc tgccgagacg aaccacgacc gaggggagaa tgtccgccat
    16381 gacgacagac gcgacgaagg agacagcgga tcgaggccgg ggtcgaccgc ccatgagcca
    16441 acaacgtcgg gatgtcgtcc gtctccagat cgcagccgcc gcgctcgacc tgttccgagc
    16501 ccaaggcgtg tccgccacct ccgtcgacca gatcgccgcc gaactggaga tctccacccg
    16561 gacactctgg cggtacacct cgtccaagga ggcctgcatc gaaccgctgc tgacgcacgg
    16621 catctcggtc gtcgtgcaac gcctgcgcga ctggccgcgc gaccagcccc tgctcgccca
    16681 tctcctgcac gaggacgacc tctacgagga cgtctcggag tccactttgg aactggtccg
    16741 cctgatgcgc accgaacccg gcctgatgtc ggtctggctg cgcacccacc tcgacgccga
    16801 gcaggccttc gcctcggtgc tggccgaacg caccggacgc tccgccgacg ccctggagac
    16861 caaggtccag gcgggcatgc tcaacgtcgc cctccggctc gcgatggaac accacgcctg
    16921 gcgcgccgac catccacagc gcgactcgac cggtccggac aacctgaccg aggcgaccga
    16981 actggccctg cgcacggcga tagccggact cgccgtctga tattcgaggt atcgcctact
    17041 accccattcg tcgcagcgat aggaatcgca aaggaaccaa caagcggacc gagggaccga
    17101 acagtccacg caccgttccc tttggtgccc gcgtccgctc acatcgacga caatggaacg
    17161 agcggcccct acagtcgttc ccatgacgga gatcgatgta ccccaggttg ccgatctcga
    17221 gatagccgct ctggtgcgcg ccgaagtgga gcgacggtgg ccactcgacg tccaaggaat
    17281 cgaagaactc gcccgttacg ggttgattcc cttcggtaag atgatgggcc catggttgct
    17341 gatccggtcc agtctggcga ccggcggcga cgtcaaatcg gtactacccg ccgccgtggc
    17401 cgtcgaatgc attcaggtcg gcgccatgat gcacgacgac atcgtcgacg gcgatccaca
    17461 gcgacgcagc aagctggccg cccatgccgc gttcggccag ggtacggcca tcatcggtgg
    17521 tgacggcctg ttcttccacg gcttcgccgc cctggccgac tgccagcggg cgggcgcgcc
    17581 cgtcgaactc gtcggcgcgg cattgaccat tctgtcccag accggactgc gcatcggaaa
    17641 cgcggcggtc gaagagatca gaatgggtcg gagtatctgc tccaccagta cctacctgaa
    17701 catgattaaa gacaagagcg gcgcgctgct ctggatggcg tgcggcgtcg gcgccaccct
    17761 cgcgggcgcg gatcggaaat cacttgcggc gctgcggagc tacagcgatc tcctcggtgt
    17821 cggatatcag attcgcgacg atctgatggc ctacgacgga actcgggccg gtaagccgaa
    17881 catttccgat attcggaacg gcagaccgac attgccggta ttactcgctc atcggcggtc
    17941 caccagagaa caacaacgac tgatcgaaca tctgctggcc gacaccacca cccccgtgga
    18001 ggaacggcac gaggccatgg cggagatcgt cgaggtctcc ggcgcggtcc gatcggcgcg
    18061 ccggatgtcg catctctacg cccacctcgc gggccgggca ctcgacgaac tccccccgtc
    18121 cgtgcaccgc gacgtgctcg tggaactcac ggtgcccggt cggctggtgt gaccgccgcg
    18181 atcacggcca ggaggtgact catgactgcg atgacctacc cccgctacct gcacctcgcg
    18241 gagctgctgt ccctacagca cccgctcacc gcgcccctcg aacaagacct gcatgacaac
    18301 gagcgactgt tcatcagcgt gcaccagatg tcggagctgc tgttgagcca ggtcctcgtg
    18361 gatctccggc acatcaagga gaaccggtgc accgcccgct gcttcgcgca ccgggcggac
    18421 cgggccaccc tgatggtgga gtccctggag gcacatctga cgctgctgcg ggaaacgctg
    18481 cgcccggagg ccttcctgat gttccgggac cggttcggca gcgcgagcgg cttgcagtcc
    18541 gcacagttcc aggagctctt ccggctgacc gaccgcctgg agaccaggga atccagcctc
    18601 ccgctggaac cccatcgcct cgcgaggctg cggaccgcca tcacccactg gcgccgaacc
    18661 catctcgggc tggtcaagta catgatcggc gacctgcccg gatccggtga caccgacggg
    18721 gtccggttcc tggcgaagcg gctggccggt tcatccctcg acgacaccgc caggcatcca
    18781 cgaacggact ccgagaaggt gcgaagtgag cacggtgtct cctgatccct cgttcggcca
    18841 cgtcgtggtg gcgggcggca gcgtgtccgg cctgctcgcc gcactggtcc tgtcgcgcca
    18901 cgccgaccgc gtgacggtgt tggagcgcga ccactacccc ggcggtcccg aaccgaggtc
    18961 gggcgtgccg cagtcccgac acacccatgt cctgttgacc agcgggatcc aggcattgga
    19021 cgagctgctt cccggggtgg tcgacgagct gcgcgccgcc gacgcgccat acctctcggt
    19081 gcccgccgac gtcggtgtct ggcaggccgg ccaatgggtc tcgcgggatc acccgtccca
    19141 gccggtcatg tccgcctccc gcccgttact cgaacagctc gtccggcggc gggtgttggc
    19201 cgcaccccgg atccgggtct ggacctccac ggcggtgacc ggactcctgg gccgcgccga
    19261 ccaggtcacc ggcgtgacgg tgcgggatcg gggcaccgac cagcagtccg agcgggccat
    19321 cgaggccgac ctggtggtgg acgccaccgg ccgggccagc cgcttcgacg aatggctcgc
    19381 cggtctcggt ggcgcacccg tcgccgagga gacgttggag accggccgcg cctatgcgac
    19441 ctgcgtgttc cacgccgacg agcagcactt cgatcggcag ctgcggggct tctacatcgt
    19501 ccccgaggcc gcacagaccc tcggcgcgat catcctgccc gccgagggcg accgctggat
    19561 ggcgacgctg tccgggcctc gggggcaggc gccgcccacc gacccggccg ggttcgtcga
    19621 cttcgcgcgc gacctgccgc accaggcgcc gcacaccttc ctgcgctcgg cacgaccgat
    19681 cggcaaaccg gtgggatatc gacacaccgg caaccgcagg cgccgctacg accagggccg
    19741 ggatcggcgc ggactgctcg tcgtcggcga cgcggcctgc gcgttcaacc cggtctacgg
    19801 ccagggcgtg tcggtggcgg ccatgaacgc gacggccctg gaacgtctgc tgaccgggac
    19861 gcgcgtgctg ccctccacac accggatgca gcgtgtcatc ttgcgttcct cgcaggccgc
    19921 ctgggagatt gccacgggag cggacagcca catgccggga gccgagggca atgcggcacg
    19981 caccggtccg ctcgatctac tgctcaaccg gtacctggac cgggtccgcg atcgagtccc
    20041 cggtgatccg gtcgtgtgcc gggcgtttcg ggacgttctc ttcctactgg ccccaccgag
    20101 tagcctgctc acctcgtacc aggtggtccg gcggtcgctg ctgcatccgg tggccgcacc
    20161 tcgttccgac gtgctcacgc catgatccgc ctgttttcgt gaccagacct ggaggttcga
    20221 tgccatgcga cgaacaaccg cgcccggcct gctcggatca ccgcgagcga cggtgagacc
    20281 atgactgcga ccaggatcct gccctcggcg ctgacctccg gcgtcgcgct ggtggaaccg
    20341 gctcttcgcg aggccgtcgg acgactctgc ccacagatga gcgtcgtcgg gcgctaccac
    20401 cacggctggg ccgacgccca aggcagggag atcgatgggt ggggcgggaa gctgctccgc
    20461 cccacgctgg cgatcctctc ggcccgcgct gcgggagccg agccctcggc aggggttccc
    20521 gccggggtcg cgatcgagct ggtgcacaac ttctcgctgc tgcacgacga catcatggac
    20581 ggcgacaccg agcgtcgagg ccgggccacg gcgtggacgc tgttcggggt gccccgcgcg
    20641 atcctggcag gcgacgcgct gttgaccgcg gccgccaccg agctactcgc ggccgaggcc
    20701 tcgggcgcgc gcaccgccac cgcctcgctg atggccgcca cccagcgcat gatccgaggc
    20761 caggcctcgg atatggactt cgagggacgc accgacgtct cgcgggacga gtgcctgcgg
    20821 atggccgcgg acaagaccgg tgcgctgctg gcctgcgcgt gctcgctggg tgccgacctc
    20881 gtcgatgcgg accggacgct ggtggcgcgg ctcgccgact tcggtgagca cgtcggactc
    20941 gcgttccagt tcatcgacga tctgctgggt atctggggcg atccggcgcg gaccggcaag
    21001 gcggccgggg cggatctgca cagtcgcaag aagtccctgc ccgtggtcgc ggcgctcaac
    21061 gcgccggatt ccgccgaact gcgcgccctc tacctgcgcc cggagccgtt gagcaacgac
    21121 gaggtcgcgc gcgccgccga tctggtggag cgcgggggcg gtcgcgactg ggcacgcgcg
    21181 gaggcggatc gacacgtcgc ggcggccacc gagtcgctcg aggcgtgcga catcccggac
    21241 gcggtgcgcg gtgacttcct cgaagtcgcg gccttcatca ccggccgacg gttctgactc
    21301 cggcggggtc gatggcgtgc gcggtatgag gttccgccgg cagtagagct gtcggcggcg
    21361 ccttcgccgg gaccgggcgg cggggcggac tgttcggcga actcgcgacg ttgcgaggtc
    21421 gacgagctca gaacgtcgag tctcccagtg gcgtcgatcg gtcgcgcacg ccgatcagcg
    21481 cgccatggac aggttggtct cgatgccgcc gacactgtcc agcagcacac cgccgatctt
    21541 gcgtagatcg agttcgttcg ccatgccgca cagcacgatc gcggccaccg ggtactggtt
    21601 gccgaggtgg atcggcgcgg ccacctcgac gagcccgggg atggcatcgc tgcgtgacca
    21661 ggacagcccg gtccgccgga tcgagtcgaa ctcgcgccgc aacaccttgg ccctggccgg
    21721 attccagccc gtctgcccgg tggggacgat gccgcacagc tccgagggat cgctgacgct
    21781 gcgcgccaac agcagtcgcc ccgccgcaga gccgaaggcg ggcaccggtt cccgccaggc
    21841 cgcggcgatc cggcggtgat cacgccggta gaggatcccg gtatgccaga cctccagacc
    21901 cgacagcgct ccgacgctga ccacgagtcg ggtggtctgg aagaggtcga gcaggaaggg
    21961 cgtgagttcc tcactgatgt tgcgcacccg gtcgggaccg ttggaggccg ccagctggaa
    22021 gatgtagctg cccagctcgt aggacttcga ttcccgacgg tcggccaggc ccagctcggt
    22081 cagcacccgc atctgccggt gcagggttga tttgggcagg ttgaccagtt cggagagttc
    22141 cgagagtgtc agcggcccgg aggcggcggc cagctcctcg agcaccgcca acgatcttcg
    22201 aagcggtccg ccgccgctct tcgccgcgtc accggagtcg tcgggacccg cctcggcatc
    22261 ggggcgacca ccacgtcggg gttgcgggga tgttgccgca gcctgctgga gcggtgtcag
    22321 ccgcacccgc tccaggccga tcggcgcgag gtccaccggc accgcctcgg agcgccgcca
    22381 tcgaacctgg gttctcccgg agtcggacat ctgttcccct ttcgataatg ctctaaccac
    22441 ccgacagact ttccccagct gatcgttgcg tagcacgatt gaatcgaccc cgccaaagcg
    22501 agcccgagtc gctatatagt gcgctcagat gagcgaatca gttgacaaaa attagattgc
    22561 gatggcctat tcggaccatc ggagcactat cgaagacagc aggacgctaa ttcggataga
    22621 catgctaaag ctcgccttcc ggcggctgca ccccctacgg gcagggtcga ggggacggtg
    22681 acgcgcaggg cgacaacagg tcgataccgc acggtatccg ccggtagatg cccgcgaagt
    22741 gcccgtaaga agactgccga acacagtcag atgaacttta cgaacacgtt aaagaaagaa
    22801 gctgcacgac agtctcaaga cgggggtcac ggtcctccct ggtgatcgca ggctggcagg
    22861 ctgattccag ttcggtcgac tgactttcta taggtagacc gaatacggag ccaggtgggt
    22921 gccattctcg gcggcgacca agaacgctgt gtgcggccac aataatcaca tactcgtcac
    22981 ggcacttcaa tggtgtctcg atcaccggat cgctttccca tgatgaggac cgcgcatcgt
    23041 cgtcggccga cctgtcgggt gacgccgagg tgtgccccgc ccccgatgct ggacaggccc
    23101 tcgcccatcc gacaagactc cccccgtgac catctggatc tgcgccacct gcggggtcga
    23161 gcatcccgac tccgaacgcc cgccgaactc ggactgtctg atctgtgccg acgatcgcca
    23221 atgggtcccc gagagcgggc aggtctggac gacgctggcc gagctggcag cccaggatca
    23281 ccgcctggtc cacgaggagc tggaacccgg tctacatcgg atcaatcggg aacccggtct
    23341 cggcatcgga cagcggacct atctggtgca gaccgaacag ggcaacctga tgtgggatcc
    23401 gccgaaccac ctcgatgaga cgacggtgcg gcaggtggcc gcgctcggcg gcgtctcggt
    23461 gatcgtcgcg agccacccgc acatgttcgg ctcccaggtg agttggagcg aacgcttcga
    23521 cgcggcgccc atcctggtgc actcggcgga tcgccggtgg gtgcggcgcg aatccccggc
    23581 catccgcgaa tggagtgggg tcaccgaggt actgcccggc gtgacactgg tgaccgcagg
    23641 cgggcatttc cccgggtccg ccgtcgccca cctcgcccac ggttcggagg ggcgcggcag
    23701 tctcctcgtc ggggacacga tcatgccggt actcgactcg ggctgggtca ccttcgagcg
    23761 cagctatccg aatcggatac cgctctcccc cgcgatcgtc gcgcgcatcg tggatcgact
    23821 ggcgccctac cccttcgagc ggctctacgc gttgacgggc ggccgcgtcc tggccgacgc
    23881 gaagaacgcg gtgcatcggt ccgcgcagcg ctacatcgac tgggtcggcg gcaagtacga
    23941 ccatctctgc tgacgggcag gtcctgcggg cgcggattct ccgtggggcg tcgggatcag
    24001 tcgtcgagca gccaccacac ggccagggcg atgctggctc ggagtaagcc tgcgggctcg
    24061 gtgagctcga tgcccagcga cggtaacggt ccgagctggt cgagtcgacg cgagacgctg
    24121 ctgtggtgcc ggtgcagcaa ctcggcggga ctccagaccc ggtcgcgcca aggcggatcc
    24181 gggtcacacc cgccgtcggc ggccgggttc gcgccctacc ggtcgcgcca ccaacgggtc
    24241 aacgactgcc accaagcggg accggtctcc tcgccatcgg attcgctcgg cgtcggcctg
    24301 gccgtcggcc ggggcaggtg cacggtgtcg ggctccggag ctcgcggcgt cgaccgatcg
    24361 ctcgtggacc gcgcgcccac tgcggtgaag cgcaccggca acccggccag cgcccggtga
    24421 taggggcccg gccgccaggt caagcgatcg gcgggcaccg ccagctccag atccggcaac
    24481 cggtccagca ggcgctcgat gcccaccgtc gcgatcaccc gcgcaggggc ctgcgccgga
    24541 cacgagtgcg gaccggcgcc gaaggccaga tgggcccggt tgcccgccct ctcctggcct
    24601 acggcgagtt cggggtcggt gttcgcggcg gcgaagctga tcaacaccgg ttggtgcgcg
    24661 ggcagcggca cgccctgcac ctcgacgtcg cgcaccggga acatgggggc gtgattggcg
    24721 atcggcgggt ccgcccacag cacctcggtg agcacgtcct cgaccaccac gctgcccgag
    24781 accgcgcctg cgaagcgttc gtcggagagc agcagtcgca gcgagttggt gatccagttc
    24841 tgcaagggct cgacgccgta tcccagcgcg gtgagctgat cgacgacctc ctcgtcggtc
    24901 agctcggccg ggtggtcgag catcgcggag gtgacgtccg tgccgcgcct ggcacgtttg
    24961 tacgcgacca gttcggacac gctctcgtgc agatcgaccg cggtgcggtg cggcgaccgg
    25021 ttcttcgcac gcaccgcccc ggccatcagc cgtttgccaa ggcccgccga ggcaccgtag
    25081 agctgggcca gcaccagcgt cggcagcacg gcggcgtagt cggcgagcaa ctcggcccga
    25141 ccggcgccga tgaactcgtc gatcagcagg tcggcgctgc gctcgacgga ggcacgcagc
    25201 agcgtgggat ccacccggtc caggccatcg ctcatcgcgc cccgcagccg ggcgtgggcg
    25261 ctgtcgtcga cgatcagaca cagtggttgg aaggccatcg cggcgatcat cgaggcggtc
    25321 gggggcaggg atcgctgcca gtggtgcggg tcgcggggaa acgagatcgg gtcgcggagc
    25381 accgtcagag ccgccgagta gtcggtcacc agcgaggcgg ggacaccggg ggccagctcg
    25441 accttggcga ccgggccgtg ttcgcgcaga tcggcgtaga accgggcggg atcctgcgag
    25501 aactcggctc cgtgcaaggg aatccgcgcg gcgtgggccg ggcagcgggg ctgcgcggca
    25561 gcggcggcat gagcggaatc ggcggtcact ctggctcctc gggatgaacg gcgtcgaggg
    25621 atcgtcaccg tcgacgcaca acgcggattc gcacccgcaa ggcagcgact atacgagcgt
    25681 tgcgatcccc gttccacgga cgcgaaccac cgcacgggcg ctgggctttc gaccgccgcg
    25741 agtacccacc gagacacgcc cgtgatccgc tcgaaaccag tacgtaccgt gatcgtctcg
    25801 gttcggggga atacgtgaac gaccaggtcg ccggctcacc gcaggcggtg agacgctcac
    25861 cgacagtgaa ccggcggcca ggccgggtgt tgccggtcac atggacgccc gcactacccc
    25921 gatcggccta gcggcggtgc atccggcgac ccggcccgat cgccgccccg cccgaccgga
    25981 cccgaccgga cgcgcccgac cggaccgccc gacgacgtcc ggtcatcctt ggtgcggccg
    26041 agggcgaacc ggcgcgagca gcatcccggt gatcccgtcg gtcaaggcat ccccgatgag
    26101 ctcccagtcg gcggggacac cggtgtcggc ggccgcacgc tcctgctcgg cacaggtgtg
    26161 cagcaccgcg agtcgcgcgg tctgataccg cagtcgagtc aactccgacg gcagatccgg
    26221 gacgtgggcc gacatcgcgt ggtgcgcgtc ctccaacaac gccgccaact cgggcgccca
    26281 cagcaccacc ccgacgtagg cgggatcggt ggccagctgc gccgcgaacc gcgcatacca
    26341 actgggcgtg cccaggctcg ccaggtgctc ggtgtagggc cgcaccagac agccgaggta
    26401 ctccccggga tccgaggagc cccgcgtctc gtcgaacagc tcccggctgc ggcgggtgat
    26461 cggttcgacg tgcgccctac tgatcgcgcg cagcaggtcg gcccgggtgc ccacgtggta
    26521 ggccaacgcc gagttgttgg cctgccccgc agcctcgacg atctgcctgc tggacacctc
    26581 ggacagtccg cgttcggcga acaaccgttc tgcggtgtgc agcaggtgtt cccgcgtgac
    26641 ctcggcccgc tcccggcgca cgccggagcg cctgcgctgc gccgagtcgg tgtccacggc
    26701 ggtcatcgtc tcaccaccgc accgggacct cctccaaacc gccgaccaac agaccctcgc
    26761 ggcgacgcag ctcctcggcc gggatcgcca actccaggcc gggcaaccgc tccaacagca
    26821 caccgagcac cgtggtcagc tcgatacgcg ccaatgcctg cccgaggcag gaatgcgggc
    26881 ccgcgccgaa ggtgaggtgc ggattcggcg agcgggtcag atccatctcg tcggcggcgg
    26941 cgaaggcgcg ctcgtcccgg ttggcggcct gcatgagcgc caacacggtg gtgcccgcct
    27001 cgatcgtggt cccgccgacc tccacgggtt cggagatgtg ccgatgcatt cccgaggaac
    27061 ccaggttcgc gtcgaagcgc agtacctcct ccaccgccga cttcaccaga ctcgggtcgg
    27121 ccaacagctg ctcccagcgt tcccgtttcg acagcagcat cgcgaccatc ttgccgatca
    27181 tgttggccgt cgtctcgtgc ccggcgatca gcagtgcctg cccggacagg atcagctcgg
    27241 cctcggagag tcgtccgtcc tgctcgtcgg cgatcgcggt caactccgag agcaggtcgt
    27301 caccgggttc ggcgcgcttg gcacgaacat gcgcggtcag gtaggcccac agctcccggc
    27361 ccgcggtctg cacctcggcc tgggtgtagc gggtcaggtt gagcatgtgg tcggaccagt
    27421 gcgcgaacct ctcccggtcg gcggccggga cccctagcag ttcgcagatc acgtataccg
    27481 gcagcgggaa gcccagggcg ctgcggagat ccgaggtcgg tccctgcgcg accatcgcgt
    27541 cgatcagttc gtgggcgatc gtggtgatcc gaggttgcag ggcggtcatc cgcttgaccg
    27601 tgaaggaacg gctcagcagg cgtcgccacc gcagatgccc ctcgccgttg gcgatcgagg
    27661 cgggcacgga cagcggttcg tcgttcgcgg agtcctcggt gggaaccggc ttcctggtga
    27721 atcgcgggtc ggccaggatc tggcgcacgt cgtcatagcg cgtcagcagc agagcgtcct
    27781 ccccgaccac ggtgcgcacc cgggcgaccg ggcactcatc gcgcaactgc gaccactcct
    27841 cgggcggttc tagggcggtg ggcagcgcga aggggaaggg caacgcctcg gcggcaccac
    27901 ccggtgccgc gtcgggcccg atcgggcagg tcgtggcggt cgcagtctcg tcgtcggtcg
    27961 cagtctcgtc gccggtcatc cgcacctccg tattaagaaa agcatctgac ttaaacgata
    28021 gcgtaaagat cgcatcgact ggcgggccgc gatggggccc gcaatgggcg ttgccgtgct
    28081 caccatggca ggcaacccca gacccatacg aagcccgccg gaaatgccac cggggcccgc
    28141 gccacgccgt ccaacgcgtg acgcgggccc cggtgtgagc cgctgaggat caggtcggga
    28201 ctactccgcc gcgcagaacc ggtcctccga cacccgctcc cccgtgacca ggtaatccgt
    28261 caccgagtcg ttcgcgcacg cgttcgtgcc gaacaggtac acaccgtggc cgccctggtc
    28321 ggccgtcacc atccggaccc ggtcgcccag cgcatcccgc atctgctgcg cgccgatcag
    28381 gggtgtcgag gcgtcgcggg tgttctgcac caacagcacg ttcgacggac cctggtcgtc
    28441 gacctcgacc ggggcacggt cgatctccgg ccagaacgcg cacgcccgga tgttggccgc
    28501 tgcgggtccg tacatcgggt agggctttcg agcagcctcg acgtcgtcct gataggactc
    28561 gatcgacctc gaccactcgt tgtcgccgca gagcacgtac aggtggctgg acagagggtt
    28621 gtcgaaaccg aggtcatcgg tgtcggacaa cgtgagcggg ttgctcgcca ccgagacggg
    28681 ccggcccgcc tcggcctgct gccacagctc gaccagtgtc gggaaatgcg agtcacgggc
    28741 gagattggag agggtggcga tgcggaacaa cgcacccgtc agctccgttg tcggctcctc
    28801 gtccagccgc tcggcgatct cgaagtactt cgcccgcacc tcgtccgggg tgttgccgag
    28861 gccgagttcg ggccgcgcgg cggcgtaggc cgcgaagtcc gggaatcgct cctcgaagcc
    28921 gggccccatc agcttgcccg cctcgtggtc gagtccgttg ggcggcagac tgctgtcgat
    28981 caccacccgg tcgctggtct ccgggaacag cgtggtgtag acggcgccga ggtgcgtgcc
    29041 gtaggagtag ccgaggaagg acgcggtctc ctccccgagc gcctgccgaa ccatgtcgag
    29101 gtcgcgggcg gcgttggcgg tggtggtgtg cggcagcatc caggctgtct cggaggtggc
    29161 gcactgctcg gcgacgagtt ccacctcgac cgcccgttcg acgacgtcct cggcattgtg
    29221 cgcgtatggc ggcaggttgc ccatgagctg ctgttccaag gacagatcgc aggtcaccgg
    29281 ggtgctctgt ccgacgcccc gggggtcgat tccgatgatg tcgtaggaat cgagcacgct
    29341 ctgcggcaga ccggcgtcct tgaggtcggt cgggaagttc aacccggagg cgccgggacc
    29401 acccggattc gtcagcagca ccccgcgtcg ctgttcttgg ttgtcgctgg ccagccggga
    29461 gatcatgatc tcgatctgtc gcccggtcgg atcctggtag tccaggggga cgtccagcgt
    29521 cgcgcactcc agggtggtca cgccggagtc cgccgggcac tcgccccact gcaagggggc
    29581 gggtgtggga ctcgcctgtt gggacgtggc cgcctgggcc acgccgggaa ccacacacgc
    29641 ggccacgacg gcgacgagtg cgaacgccga ggttctacgc atccgggctc tcctttcggg
    29701 gtgcggcgca tcgaggcgcc ggttcggtgg aagtcaatgg cggcgccggt cgattcgacg
    29761 gccgcgcggg gaggtcagcc ggtcgagccg cgcgcccgct cggcggggcg acctgcgttt
    29821 ccggcttggt catgccctcg actgaacacc ccgcccttgg gtcgggctca agtcccgaac
    29881 cggtgtgatc caccgcactc cgaacgccgg gatgcgaacc cggacttgac ccggccccgg
    29941 cgtcagggtt ttggctgtag gcacaccgcg gctcgatcgc cgggcccacg cttcgacgtg
    30001 ggtgggcctg gcaacgcggc gcggtgcggc ggacagcgcg gcacccgcgt cgcaggtgcc
    30061 cgcccatccg gagcgaaagg agttctgtcg ttgcgcagca gcgagttggc caatctggcc
    30121 ggagtcaccg tccgtgccct gcggcactat cacaagatcg ggctgctcga cgagccggaa
    30181 cgttcgctca acggctaccg cacctacgat gtgcgtcatc tcgtgcggtt gctgcggatc
    30241 acccggttga ccgggctcgg tgtcccactc gcggtgctgc cggaggtgct cgacgacccc
    30301 gaggccaccg aggtactgct cgatgaactg gacaagaacg ccgctaccga gatcgagcgg
    30361 ttacagggca ggcgcaaggc catcgccggg ctccgcagca acggaatgac gcccgaccta
    30421 ccgcccgcga tggccgccta tcttcccgtt tacaccgcca tcgccgaggt cgaccccgag
    30481 ctggcccgct acgagcgcga acagttcatg ttgatcggcc aggtgatcgg cgaaaccgcg
    30541 ctggccacct tcgcggacta tgtcgcgcgt cgtttcacct tcgatcccga ctcgatgacg
    30601 ctgttacgcc gtttcgcctc gctcggcccg gacagcacgg agagcaccat ggccgagctc
    30661 gccgatgaga tggcgctgca ctatcaacgg accttcgacg ctcccctcgg gatcacgatg
    30721 gacaggcagc tcatcccgat cctcaccgca cacgtcgaac acgtcctcaa cgaacaacag
    30781 gtccacacca accgactcat gaacgagcgc ttcgtcgaac tggcgaggca gcagcaggcg
    30841 atccgggcga cgtcctgagg atcacacggt gcgcgccgcc gagcccgcga gggcgaatcc
    30901 cgtcgcggcg gtcgcggtcg cggcccgtcg gaactcgctc gggttgacgc ctcggatccg
    30961 tttgaacgcc gcgctgaagc cgaacggatc ggagtagccc actgttctgg cgatctccgc
    31021 aacggtcgcg gcaggctgct cgaccagcag gtctgcggcg agcgtcatcc gccagcctgc
    31081 gagataggtc agcggtggtt cgcccagcac gtcggcgaag cgcttggcca gggtcgaccg
    31141 ggacaccccg gcctgccggg caagtgcggc tacggtccat ggtgccgcgg gttgggcgtg
    31201 cagcagtcgc agcgcctcgc cgaccaccgg gtcgcgctgg gcagcccacc aggccggggc
    31261 ctcgccgtcg ggccggtcga accactcgcg cagcgtg
//
