LOCUS       NZ_CP014859            22491 bp    DNA     circular CON 20-NOV-2024
DEFINITION  Actinoalloteichus hymeniacidonis strain HPA177 chromosome, complete
            genome.
ACCESSION   NZ_CP014859
VERSION     NZ_CP014859.1
KEYWORDS    RefSeq.
SOURCE      Actinoalloteichus hymeniacidonis
  ORGANISM  Actinoalloteichus hymeniacidonis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Actinoalloteichus.
REFERENCE   1  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J.,
            Zotchev,S.B. and Ruckert,C.
  TITLE     Complete genome sequence of the actinomycete Actinoalloteichus
            hymeniacidonis type strain HPA 177T isolated from a marine sponge
  JOURNAL   Stand Genomic Sci 11, 91 (2016)
   PUBMED   28031775
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6306386)
  AUTHORS   Schaffert,L., Albersmeier,A., Winkler,A., Kalinowski,J., Zotchev,S.
            and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2016) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Coverage                   :: 159x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001747425.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 01:17:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,434
            CDSs (total)                      :: 5,374
            Genes (coding)                    :: 5,337
            CDSs (with protein)               :: 5,337
            Genes (RNA)                       :: 60
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 3 of 37
            Pseudo Genes (incomplete)         :: 34 of 37
            Pseudo Genes (internal stop)      :: 1 of 37
            Pseudo Genes (multiple problems)  :: 1 of 37
            CRISPR Arrays                     :: 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:46:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1630145
            Orig. end                         :: 1652636
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014859.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22491
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="7"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22491
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22491
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12491](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12491
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(157..1581)
                     /locus_tag="TL08_RS29720"
                     /old_locus_tag="TL08_07645"
     CDS             complement(157..1581)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016700087.1"
                     /locus_tag="TL08_RS29720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07645"
                     /product="PP2C family serine/threonine-protein phosphatase"
                     /protein_id="WP_084642693.1"
                     /transl_table=11
                     /translation="MTLALRFTARSDRGLVRSNNEDSVYAGPRLLAVADGMGGHVGGEI
                     ASRLVITAVTPLDDADLGGDLTRMLQDATVDGNSAIAATVEEDPELAGMGTTLTALLFA
                     DDRVGLLNVGDSRAYLLRDDQLHQITHDDTFVQSLVDAGRITVAEAEVHPKRSLVLRAL
                     TGEKAVEATTEIREVRAGDRYLLCSDGLTDVLNHAALTIALRGGDHEACADKLVEAALA
                     GGGPDNVTVIVADVVEVPAEQPAADEPADSAQAGTPTEAQSSAPAAAAPTASETESAPA
                     APEQPGHQSASTQDHPDSPTMPDEPVGSDAADESDVDDDDDHGWNAAGNRSATGVPLQR
                     PMPGRVQDVQDVQDGDLDAGEAAPSGSPAAAEVAETAEDRTDDRAPDDATAAIRRAVWD
                     SVERDLSETATTHRDVPDESAIDSPATPAHDASRADATSTLGPQPGPRRRSKRSLLMGA
                     AVLGAVATIAIRRFRR"
     gene            complement(1856..2443)
                     /locus_tag="TL08_RS07550"
                     /old_locus_tag="TL08_07650"
     CDS             complement(1856..2443)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="TL08_RS07550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="TL08_07650"
                     /product="hypothetical protein"
                     /protein_id="WP_084642695.1"
                     /transl_table=11
                     /translation="MNQPRNAPPSDEQLAVPSTPPRKPPVVIGLLILVLVAVLTSAIGS
                     VLVYSGGATMAEENLIAAIDESPEGREISRGMSSTELQEMMGPEFWDTMVAERQDTMSA
                     RASMAIFLSTLLLVFGLLALNSALWARILITIVIPFAVFPHMLITEDYPPAMLETLSMI
                     SVWTALLAIAFCWLPGHGKHSRAVKQARSSTA"
     misc_feature    complement(2099..2101)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2198..2200)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2822..2835
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     gene            2921..4009
                     /locus_tag="TL08_RS07555"
                     /old_locus_tag="TL08_07655"
     CDS             2921..4009
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663261.1"
                     /locus_tag="TL08_RS07555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07655"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_069847691.1"
                     /transl_table=11
                     /translation="MSEFNPLRFPSASGRSRLLQSPPPLLDTTLDQLRTLLAVREVGTA
                     LGAARMLGREQSSVQKQLDTMNRNFSVLCGEPLVLKQGRGKDMLFTGTGESLVEMARRT
                     LAGWLDEIDECRRSLGGILTVATTRFTLRYLADAGRFVAAEFESRGIELKVVHVRSGDL
                     FGRLRAKQVDLVCGSLVTRTDDVDELADLDVMAWRRSGLSLVTNLPPEILPDEPIRTSD
                     LPMLPLVVPSYGLITDFLRGWFGPEYLLRLEIAAEIDTVHYGFELLRSQLTRGCMLVTQ
                     GIGEAAAQGRLPEGDNLRTIELVDDVAPGLQVLAGLFARRDERAAYPDDHPLNLMWSAF
                     ARQDIQYKRRRTDTDTGSEDAG"
     misc_feature    2993..2995
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4068..5282
                     /locus_tag="TL08_RS07560"
                     /old_locus_tag="TL08_07660"
     CDS             4068..5282
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005439128.1"
                     /locus_tag="TL08_RS07560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07660"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_069847693.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.2e-50, bitscore:
                     169.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALGDTPRRIVVVGSSVAGLTVVDTVRRNGFDGAVTLIGDEVHL
                     PYDRPPLSKQVLAGDWDPERVRLRSESELHDLDVDLRLGIAAIGLDLARRRVTLADGGV
                     ADYDRLVVATGVAPRRLPDTHGVRGVHTVRTVDDVIALRTEMRPDARLVVVGAGFLGTE
                     VAASARRLGAQVCLVDPAPTPLAAVVGAEVGGFVAQLHRERGVDLRTGPAAAVRSLQVV
                     DGAVAGVELAEGDIVPADAVVVAIGSRPSVDWLAGSGLHCEDGVHCDPTCSAGSGVYAA
                     GDVARWFNPRYDVEMRIEHRTNAAEQARHVANAMFAAEPVPFAPIPYFWSDQFDVKIQS
                     HGLLRDHDEVRLVSGSFEQRRFIALYRKGSRVAGVLGVGDFRGLRRWRTALDTGVEWAD
                     AMAEV"
     misc_feature    4221..4223
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5636..6544
                     /locus_tag="TL08_RS07565"
                     /old_locus_tag="TL08_07665"
     CDS             5636..6544
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-148). E-value:
                     1.7e-14. Score: 46.0. Matches aSDomain:
                     nrpspksdomains_TL08_RS07565_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631998.1"
                     /locus_tag="TL08_RS07565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07665"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_084642697.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-14, bitscore:
                     53.0, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 7.2e-10, bitscore: 37.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLSNQAAGHSADRTRRIDGAPTYVFVHGSGSNSFMWASIQREL
                     ALLGHRSHAVDLPGHGLDAEYSASYQAPQDLQAWANEPSKLAEVTLVDNVEAVLDVVRT
                     VGAHGPVVLVGASLGGLTISGVADRAPEAVARLVYISAWSCVRLRNPLEYMAEPEFGEN
                     LLAPLAALNVGDPARLGVGRANYRTADPTLLPALKAAVMADATDAQFLTFLNILQPDES
                     LQVMAGDATVHAETWGTVARSYVRLLQDRSLPVAMQDRLIAEADALTPDNRYDVHTVDS
                     SHAGFVYRAREMAALLAGLPA"
     aSDomain        5711..6079
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TL08_RS07565_Abhydrolase_1.1"
                     /evalue="1.70E-14"
                     /label="TL08_RS07565_Abhydrolase_1.1"
                     /locus_tag="TL08_RS07565"
                     /protein_end="148"
                     /protein_start="25"
                     /score="46.0"
                     /tool="antismash"
                     /translation="VFVHGSGSNSFMWASIQRELALLGHRSHAVDLPGHGLDAEYSASY
                     QAPQDLQAWANEPSKLAEVTLVDNVEAVLDVVRTVGAHGPVVLVGASLGGLTISGVADR
                     APEAVARLVYISAWSCVRL"
     CDS_motif       5957..5998
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_TL08_RS07565_0001"
                     /evalue="6.30E-04"
                     /label="NRPS-te1"
                     /locus_tag="TL08_RS07565"
                     /protein_end="121"
                     /protein_start="107"
                     /score="12.4"
                     /tool="antismash"
                     /translation="HGPVVLVGASLGGL"
     gene            6696..7667
                     /gene="bla"
                     /locus_tag="TL08_RS07570"
                     /old_locus_tag="TL08_07670"
     CDS             6696..7667
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948748.1"
                     /locus_tag="TL08_RS07570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07670"
                     /product="class A beta-lactamase"
                     /protein_id="WP_069847694.1"
                     /transl_table=11
                     /translation="MTTKPVGAVTRRAVLGAAALFSLAGCGGDELIGAVTSSSPGDPPG
                     EPDPSTPSSAPAPTEVSRRHDRLLELEREFDARLGVYAIAVGTGNTVSHRADERFAFCS
                     AFKGLAAAAVLHRHPMSYLDTVVTYTEADLMASSAITEQHVATGMTIGALCDAAVRFSD
                     GTAGNLLLRDIGGPAELTAYTRSLGDTVTRMDRYEPTIVEATPGDPRDTTSPRAIGTDY
                     HDIVLGAALPAEKRDFLRDLLERNATLAGEQRIRAGLPAGWTVADKTGTGDYGTANDIG
                     IVWPPDAEPIAIAIMSSKDERDARYDNALLAAATEYVVDMLA"
     misc_feature    7203..7205
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7818..7833
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            8085..8903
                     /locus_tag="TL08_RS07575"
                     /old_locus_tag="TL08_07675"
     CDS             8085..8903
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="TL08_RS07575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07675"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_069847696.1"
                     /transl_table=11
                     /translation="MYFQLLGEVRFWRQGRVCEIGPQQRRLLLAVLLLNANESVHRERL
                     FELLWGDPLPRSATGSLHAHVSRLRSALGIAGGKAMAEGMSLRTVGPGYLMSMEPECID
                     AHRFEALVGQAKAASAPDAARLYGQALDLWHGEPLSDITNERARLELCVPLEERRLDIL
                     TAQIDLEIGLGHWLELVAKLTELLTRFPGRPRFAAQLMILLHRAGRTADALEVFRRLRE
                     SMDRDFGLEPPDRLAWLETSILRNDPVLQQNDFVIGGDYWRVTSRSGHRS"
     misc_feature    8100..8102
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9031..9159
                     /locus_tag="TL08_RS27980"
                     /old_locus_tag="TL08_07680"
     CDS             9031..9159
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="TL08_RS27980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07680"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_157420991.1"
                     /transl_table=11
                     /translation="MNGESVVAYEPPALEEVGVFDEVTLGRPGWGFEADWTCVMLC"
     misc_feature    9305..9318
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            9355..9945
                     /locus_tag="TL08_RS07580"
                     /old_locus_tag="TL08_07685"
     CDS             9355..9945
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697893.1"
                     /locus_tag="TL08_RS07580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07685"
                     /product="flavin reductase family protein"
                     /protein_id="WP_236750546.1"
                     /transl_table=11
                     /translation="MVTNDVATEIETDRDSSDVQPERGTDLDGPEPQDAADDVRFRLLM
                     AGFPTGVTVISTLGRGQAPMGMTCSALCSVSLGPPTLLACLRAGSPTLAAIRRRRVFAV
                     NLLHEAAQPVAELFGSGAPDRFDRVRWRIEPSWGVPVLFDDVHAVARCRVVDSKLVGDH
                     RVVFGEVTHIRHYAEIRSPLMYGRRRYAGWPAG"
     gene            10001..11827
                     /locus_tag="TL08_RS07585"
                     /old_locus_tag="TL08_07690"
     CDS             10001..11827
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="TL08_RS07585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07690"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_069847698.1"
                     /sec_met_domain="Asn_synthase (E-value: 7e-38, bitscore:
                     129.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFVILPDCPQGTSVAESIGGAGTTVVEHPSGRPWIVGRWSPGEI
                     VAASAGRHRIVALGIAATTAEDLAARLGRIRDLGELDRIRSALPGSYHLVASMNGRVGA
                     LGTLSTARQIFHTRIAGVVVAADRPQSLAALSGACLNEEFLALQLISPYAPWPLSDYNP
                     WRRVEALSAGHRLELDRDGSGREVRWWRPPAPEVPLTEGAERVRAALHDAVAARVATER
                     PLSTDLSGGMDSTSLAFLAAGQVDRFVTTRWQATNVDDEDQNWAQRAAASIPNAAHIVL
                     ERQGIPMNFAGLLAGDPDIEAPFAWIRTRERLAFQAGRLAELGSTMHLTGHGGDELFFP
                     TPLQLHALLRSQPWTAIKYLRGFRSIYRWALPDTLRGIAADQSFPGWLAGSAATLTDSV
                     RGVNRTPNFGWWGQFRTPPWVTRTGVDSVRELLADAAAKTPEPLSPIRAQHATIQDIRK
                     CGESIRRVGRLTARHGVDWQAPFVDDQVVEAALSIRFADSASPHRYKPVLVESMRGTVP
                     TEVLGRGTKSEYSADVYAGLRSCRGELAELCDDMLLAQRGLVDADRFRTTLLGQHTSSA
                     GLSLVVATLACEVWLRSVAAFAPTAVLTGGAR"
     aSDomain        11824..12078
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_TL08_RS07590_Stand_Alone_Lasso_RRE.1"
                     /evalue="3.80E-28"
                     /identifier="RREFam002.1"
                     /label="TL08_RS07590"
                     /locus_tag="TL08_RS07590"
                     /protein_end="85"
                     /protein_start="0"
                     /score="88.3"
                     /tool="antismash"
                     /translation="MTFTLAPDVSLTDVGDSMVLLDEKGGRYWQLNATGAMVLRRLLAG
                     AQVAEIVETLSERHPAAADRVASDVEAIIEALRAAKVVTR"
     gene            11824..12081
                     /locus_tag="TL08_RS07590"
                     /old_locus_tag="TL08_07695"
     CDS             11824..12081
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PqqD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="TL08_RS07590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07695"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_069847700.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 7.3e-26,
                     bitscore: 88.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 2.5e-08,
                     bitscore: 32.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.8e-14, bitscore: 51.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1.8e-07, bitscore:
                     29.1, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFTLAPDVSLTDVGDSMVLLDEKGGRYWQLNATGAMVLRRLLAG
                     AQVAEIVETLSERHPAAADRVASDVEAIIEALRAAKVVTR"
     aSDomain        11902..12075
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_TL08_RS07590_PqqD_RRE.1"
                     /evalue="9.40E-10"
                     /identifier="RREFam006.1"
                     /label="TL08_RS07590"
                     /locus_tag="TL08_RS07590"
                     /protein_end="84"
                     /protein_start="26"
                     /score="29.1"
                     /tool="antismash"
                     /translation="RYWQLNATGAMVLRRLLAGAQVAEIVETLSERHPAAADRVASDVE
                     AIIEALRAAKVVT"
     gene            12078..12491
                     /locus_tag="TL08_RS07595"
                     /old_locus_tag="TL08_07700"
     CDS             12078..12491
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670107.1"
                     /locus_tag="TL08_RS07595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07700"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_069847702.1"
                     /sec_met_domain="PF13471 (E-value: 5.9e-26, bitscore: 89.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMPVMLEPSVDVGMRRRAAARVAVAASWLLIRLSPRRLRRVLEV
                     LRRGARPASARQITMARNAVVAVSVRCAGQGCLQRSVATVLLARLGGRWADWCTGVCIE
                     PFRAHAWVEVDGVPIGERDDVAGYRTMLAVRCR"
     gene            12532..13074
                     /locus_tag="TL08_RS07600"
                     /old_locus_tag="TL08_07705"
     CDS             12532..13074
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.5"
                     /locus_tag="TL08_RS07600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07705"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_069847704.1"
                     /transl_table=11
                     /translation="MTSYVLLADRFLIAVVFGVAFIGKIAGATAFRQFAATVRQLTRFP
                     EPVVTGIAAFIVLGEAATVALLVLPGTTGWGFTLAIGLLVLFIGVVARAIQAGVLVECR
                     CFGRGSVMTSAMILRNLLIIAVAVIGLVLSPGEPIGDLGYAAVAALVGLAGAAFFIRYY
                     DALVRVVLGRLAPQVEA"
     gene            13107..14042
                     /locus_tag="TL08_RS07605"
                     /old_locus_tag="TL08_07710"
     CDS             13107..14042
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335178.1"
                     /locus_tag="TL08_RS07605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07710"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_084643594.1"
                     /transl_table=11
                     /translation="MIEAIGLGKRFGEVAALTDVDVAVPRGTVLGLLGHNGAGKTTLVN
                     IVGTLARPSSGTVRVAGYDVVRQASQVRSRIGLTGQFAALDERITGRDNLVLVGRLLGA
                     SRRDARRRADELLELFGLTAVAHRLAKTYSGGMRRRLDLAIGLVGHPEVIILDEPTTGM
                     DPTSRLDLWQTVREMVRQGSTALLTTQHLEEADRLADSITLLSGGRVVLSGTPTELKAR
                     VGRRAVTVRLARDEVSSAVPALRRAGLQPVRSDSRDTELTIAVGQSREITSVVRALDEV
                     GIEAAELGITEPGLDEVYLFVMDNAVADAR"
     gene            14097..14960
                     /locus_tag="TL08_RS07610"
                     /old_locus_tag="TL08_07715"
     CDS             14097..14960
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783740.1"
                     /locus_tag="TL08_RS07610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07715"
                     /product="ABC transporter permease"
                     /protein_id="WP_236750548.1"
                     /transl_table=11
                     /translation="MAVDPQGRVGSAMREATAAVVDPPAARERRGTTLPDQVLVLTGRS
                     LRAVLRDPRLILTNLLAPLLMLVVFSQIFGSVAQTPGFPAGTAYIDFLVPAILINTTLQ
                     AAVSSAFALTSDMTSGIVARLRCLPVWPGSILLARSFADLVRSAIQLLLILVLATALLG
                     FRPPGGVTGTLAAWALALIVGTGLGWIFIAAACRIREAELMQGAATLLMFPLMFCSTAF
                     MPLAGLPGWLRAVAEVNPMSYGIDAARALVLGQPVGAAVITAIGMSLLVGGVAGVFAVR
                     AFRRPI"
     misc_feature    14547..14549
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15000..16025)
                     /locus_tag="TL08_RS07615"
                     /old_locus_tag="TL08_07720"
     CDS             complement(15000..16025)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683945.1"
                     /locus_tag="TL08_RS07615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07720"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_069847707.1"
                     /transl_table=11
                     /translation="MASASVPLSVLDLAPIGAGSTAADALRGSVRLAREAEQLGYDRYW
                     FAEHHDVASVASCSPSVLVAAVAAVTERIRVGSGGVMLPNHQPLVVAEQFGTLEALHPQ
                     RIDLGVGRAPAADQAVAAALRCTDAAEFPGQLGELVRFFGAPQQNQGAGTPVSAIPAVG
                     HRPELWLLGVGPRSAQLAGMLGLSFAYAHHIAPENVGSTLAAYRSAFRPSGLSSVPHTM
                     IAVGAVCAESDAQAQRLAAPAALLYVRLRTGDRHRPLPSISEAAEYSYTDQERALVAKQ
                     TAGRFVGTPEAVRAGIDRVVAESGADEVMVTTQVAGFEDRRRSYALLAEAYALDRAAVA
                     V"
     misc_feature    complement(15948..15950)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16283..17056
                     /locus_tag="TL08_RS07620"
                     /old_locus_tag="TL08_07725"
     CDS             16283..17056
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645606.1"
                     /locus_tag="TL08_RS07620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07725"
                     /product="hypothetical protein"
                     /protein_id="WP_069847709.1"
                     /transl_table=11
                     /translation="MTHQLDRRLLLQSVTALGAAALTGLTAGRSYAQPQAQLDGDFPPV
                     PGMRGDRRANEMWYHLDEVTLFNRTPEVEQAYAELYEVFGDGFMQLLFDTWSRLSGTPD
                     YETEFTEFVTPIRAALQAFSRVQLEILDLYYLPNDPRLVTAFGSFGQGILFDPRRAGVG
                     PQVHMMDGEETMSYHLWHIFLRAMMMLDIDRARWARLDPLIGYAWALQSLALPDSNAIN
                     PPLPRETVRGLAGSWLPRSPAELDRSFRSFPYPTD"
     gene            17120..17617
                     /locus_tag="TL08_RS07625"
                     /old_locus_tag="TL08_07730"
     CDS             17120..17617
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01764.1"
                     /locus_tag="TL08_RS07625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07730"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_375791892.1"
                     /transl_table=11
                     /translation="MTSNRAGEGSLGSDTVVRMSEELLTADEVAARLGLHVRTVRNYIR
                     DGRLPAVRIGKQYRITGADLAEFLGTAPELRDETPPSAGERHAAVSSIVEIDAIDRAMA
                     DRITTLLSAATAHRRPGDDHLRIDTVHDARRARLKVVMLGSLTTNAHLLGLISALVEEG
                     DE"
     misc_feature    17150..17152
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17614..18489
                     /locus_tag="TL08_RS07630"
                     /old_locus_tag="TL08_07735"
     CDS             17614..18489
                     /NRPS_PKS="Domain: Abhydrolase_1 (51-272). E-value: 1e-19.
                     Score: 63.1. Matches aSDomain:
                     nrpspksdomains_TL08_RS07630_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948997.1"
                     /locus_tag="TL08_RS07630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07735"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_069847712.1"
                     /sec_met_domain="PF00561 (E-value: 3e-13, bitscore: 48.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.8e-15, bitscore:
                     55.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAIYRSEAGARLLREKYAATLEHWPIPHERQHVPTPEGATFVIS
                     AGPEVAPPLLLLHGSGSNSTQWMGRIAELAAHFRVYAVDVIGEPGFSAPARPPWKSSRY
                     TEWLDAVLHSLGIAQTSIMAISLGGWLALDYATRHPDRVTRLALSCPIGIGRQRPGFLF
                     SALVSNSLGERGRRRNVARTLGPVLATMDPEHADAVIEQILLISANYRFRSDSLPVFDD
                     SSLRSLTMPMHVLVGSADVMVDSAQTQRRLARNVPHATVRVLPNTGHLIGDQGRIELDF
                     LLHSEPREAS"
     aSDomain        17767..18429
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_TL08_RS07630_Abhydrolase_1.1"
                     /evalue="1.00E-19"
                     /label="TL08_RS07630_Abhydrolase_1.1"
                     /locus_tag="TL08_RS07630"
                     /protein_end="272"
                     /protein_start="51"
                     /score="63.1"
                     /tool="antismash"
                     /translation="PPLLLLHGSGSNSTQWMGRIAELAAHFRVYAVDVIGEPGFSAPAR
                     PPWKSSRYTEWLDAVLHSLGIAQTSIMAISLGGWLALDYATRHPDRVTRLALSCPIGIG
                     RQRPGFLFSALVSNSLGERGRRRNVARTLGPVLATMDPEHADAVIEQILLISANYRFRS
                     DSLPVFDDSSLRSLTMPMHVLVGSADVMVDSAQTQRRLARNVPHATVRVLPNTGHLIG"
     gene            18486..18848
                     /locus_tag="TL08_RS07635"
                     /old_locus_tag="TL08_07740"
     CDS             18486..18848
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025161.5"
                     /locus_tag="TL08_RS07635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07740"
                     /product="DUF4180 domain-containing protein"
                     /protein_id="WP_069847714.1"
                     /transl_table=11
                     /translation="MIDTAWGVRAYTLDAEGVAIGTERDATDLIGELWELKPELVVIPV
                     QRFVDGFFRLETRLAGDFTQKLVNYGFRLAILGDVSEHIERSSAFAGYVREANRGRHIW
                     FVADRDELRRRLQPDR"
     gene            complement(18870..20033)
                     /locus_tag="TL08_RS07640"
                     /old_locus_tag="TL08_07745"
     CDS             complement(18870..20033)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="TL08_RS07640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07745"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_216637806.1"
                     /transl_table=11
                     /translation="MLSRLTLRWRLTLLNTALFLVVTAVVLTMVYFQNRLIIMRIGAPD
                     AEDRPISAVHGETGRSPEDVTELADGIAIQRNEALANLLGQWFLALIAMTALAGLLAWW
                     AIGRVLRRVHRMTSQARRLSMANLHERLALTGPDDEIKELSDTFDALLARLENSFAARA
                     RFIANASHELRTPLAVARTMLQVGLSTRDPGRIDRVREDLLRNNDRCIALINGLLTLAR
                     GEHDQHRREPVELAAVVDEVTDELGAGVPADGPRLHVDLPERCVVLGEPVLLAQLVHNL
                     VANALRYNIMGGEVRVELDSQGVLRIANTGPPIDADEVDRLFEPFYRGAVRAGQADGAG
                     LGLSIVHTIAQSCGGRVTARPRHGGGLVVEVRIPSARTAADARLVPI"
     gene            complement(20027..20695)
                     /locus_tag="TL08_RS07645"
                     /old_locus_tag="TL08_07750"
     CDS             complement(20027..20695)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015786722.1"
                     /locus_tag="TL08_RS07645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="TL08_07750"
                     /product="response regulator transcription factor"
                     /protein_id="WP_069853402.1"
                     /transl_table=11
                     /translation="MRVLVAEDEKTLAEYVAMGLRDQSISVDLAFDGDTALDKLTTGAY
                     DVVVLDRDLPGTHGDDICRYLIENDGRTRVLMLTAMADVGDRIAGLRLGADDYLGKPFD
                     FDELVARLDALGRRAGPAVPPMLRWHGIVLDSSRRSVTRNGRPIALSRKEFGLLSVLMA
                     AAGRIVSAEELLRVVWDEHADPFTNAVRVTMCRLRAKIGAVGAIETVPGAGYRMGGSGC
                     "
     misc_feature    complement(20968..20981)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.11"
                     /tool="antismash"
     misc_feature    complement(21292..21305)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    complement(21659..21668)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     misc_feature    complement(22310..22324)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 cgggatcgac ctactcgcgg aggccaacgc caagatcgat cgcaacgagc gtcggtttcc
       61 cgtcgagttg cagaacggtt cgatcacccg gatcgacccc tgacgcggaa tccgtcggcc
      121 gcccgagctg cgggccgacg gcttctcagc ggccggtcaa cggcgaaaac gacggatcgc
      181 gatcgtggcc acggcaccga gcaccgcggc acccatcagc agcgagcgct tcgaccgacg
      241 tcgcgggccg ggctgcggtc ccagcgtcga cgtggcgtcg gcccgggaag catcgtgtgc
      301 gggcgtggcc ggcgaatcga tcgccgattc atcggggacg tctcgatgcg ttgtcgcggt
      361 ctccgagaga tcccgctcca ccgaatccca gacggcacgt cgaatcgccg cagtggcatc
      421 gtccggagcc cggtcgtccg tgcgatcctc ggcggtctcc gcaacctcgg cggcagccgg
      481 ggagcccgac ggagcggctt ccccggcgtc cagatcgccg tcctggacgt cctggacgtc
      541 ttggacccgg ccgggcatcg gccgctggag cgggactccg gtcgcggatc ggttccctgc
      601 cgcgttccag ccatggtcgt cgtcatcgtc gacatccgac tcatcggccg catccgatcc
      661 gacgggctcg tcgggcatcg tgggcgagtc ggggtggtcc tgggtcgaag ccgattgatg
      721 cccaggctgc tccggagcag cgggcgcgga ctcggtttcc gaggccgtcg gtgcggccgc
      781 cgcaggcgcg gagctctgcg cctcggtcgg cgtgcccgcc tgggcggaat cggcgggttc
      841 atcggctgcg ggctgctcgg cgggaacctc gacgacgtcc gcgacgatca ccgtcacgtt
      901 gtccggtccg ccgcccgcga gcgcggcctc gacgagcttg tcggcgcagg cctcgtggtc
      961 gccccctcgc aacgcgatgg tcagcgccgc atggttgagg acgtcggtga gtccgtccga
     1021 gcacagcagg tagcggtcgc ctgcgcgaac ctcccggatc tcggtcgtcg cctcgacggc
     1081 cttctcaccg gtcaacgccc gaagcaccag cgaacgcttg ggatgcacct ccgcctcggc
     1141 gacggtgata cgtcccgcgt cgacgagcga ctgcacgaag gtgtcgtcgt gggtgatctg
     1201 gtgaagctgg tcatcgcgca gcagatacgc gcgggagtca ccgacgttga gcagacccac
     1261 cctgtcgtcg gcgaacagca gcgccgtcag ggtcgtcccc atgcccgcga gttcgggatc
     1321 ctcctcgacg gtcgcggcga tggcgctgtt cccgtcgacg gtcgcgtcct ggagcatccg
     1381 cgtcaggtcg ccgcctaggt cggcgtcgtc gagcggtgtc accgcggtga tgaccagcct
     1441 gctggcgatc tcgcccccga catggccgcc catcccgtcg gccacggcga gtagtcgagg
     1501 tcccgcatac accgagtcct cgttattcga ccggaccagt cctcggtcac tgcgagccgt
     1561 gaagcgcaga gcgagggtca tgaggcagct ccttcacccg tccaacctct gtgaggagac
     1621 gtccgatcgt ttcgcgccaa gggtcgtcac caccgccgac ctctgcaggt taacgcagag
     1681 ccgggacagg accggcggtc accgccgtca gtcaagtgtg cgcgaggtcg ccgtgactcc
     1741 tgacgctgtg tgaggccggg taccgctgcc gatcgatctt cgtccgacga ccactggccg
     1801 cccgtgccga ggcaccgggc ggccagtggt gactatgcgt ggcagaaaag gcgggtcagg
     1861 cggtgctgga acgcgcctgc ttgacagcgc gagagtgctt tccgtggccg ggcagccagc
     1921 agaatgcgat cgccagcaat gcggtccaca ccgagatcat gctcaaggtt tccaacatgg
     1981 caggcggata gtcctcggta atcaacatat gcgggaagac ggcgaacggg atgacgatgg
     2041 tgatgagaat cctggcccac agcgccgaat tgagcgcgag tagcccgaaa accaggagta
     2101 atgtcgagag gaagatcgcc atcgaggcgc gggcactcat ggtgtcctgc cgttcggcga
     2161 ccatcgtgtc ccagaactcg ggccccatca tctcctgtaa ttcggtggaa gacattcccc
     2221 gggagatctc ccggccctcc ggggattcgt cgatcgccgc gatgaggttc tcctcggcca
     2281 tggtcgcacc gccgctgtag accagtaccg agccgatcgc cgaggtcaac acggcgacga
     2341 gcacgaggat gagcagcccg atcacgacgg gcggcttacg gggcggcgtc gagggcacgg
     2401 cgagctgttc gtcgctgggc ggagcgttcc ggggttggtt catgggggtt ggatctctct
     2461 ctgggttgtg gaggagcgtc gtgcagggca ggcagcactg cgaccgctgt cgaagtccgg
     2521 gcacgccgcc gtagccgaga tgggttctcg ggtagtcctc tggcgcaggg cgggatgcac
     2581 tattcgatgt cccgcgtcgc aggcgcggaa ttccggatgg cggttatccc gcgttgtgat
     2641 tcggacctgt tacgtctggt ttgtgttcgg attccttcct ggggtccgcc ggtcggtgcg
     2701 gctggccggg catcagcgat gccgccgccc gttttgttcg ggagcgggag atcgagtgtc
     2761 gatcacggcc gatgaagcgg gacagatgtt acccagagat caacgaatcg acgtcgaatc
     2821 cgggacctga tctaaagaaa acttgtcatc gattggagat tagtttgctg cactatcgtc
     2881 tacgctcgcg accgaatgac cgcgaccgca agaaggaaga atgtccgagt tcaatccatt
     2941 gaggttcccc tcggcgagtg gcaggagtcg gcttctgcag tccccgccgc cgttactcga
     3001 caccacgttg gatcagcttc gaaccctgct tgcggtgcgc gaggtgggca ccgccctcgg
     3061 cgccgcgcgg atgctggggc gtgagcagtc cagcgttcag aagcagctgg acacgatgaa
     3121 ccgcaacttc agcgtgctct gcggcgaacc gctggtgctc aaacagggcc gaggcaagga
     3181 catgctgttc accgggaccg gtgagtccct ggtcgagatg gcgcggcgca cgctggcggg
     3241 ctggctcgac gagatcgacg aatgtcgacg cagtctcggc ggcatcctga cggtggccac
     3301 cacccgattc accctgcgat acctcgccga cgcgggccgc ttcgtcgcgg cggagttcga
     3361 gagccggggc atcgagctga aggtggtgca cgtccgctcc ggcgatctgt tcggcaggct
     3421 gcgggccaaa caggtcgacc tcgtctgtgg cagcctggtc accaggaccg acgacgtcga
     3481 cgagctggcc gacctcgatg tgatggcctg gcggcgcagc ggtctgtcgc tggtcaccaa
     3541 cctgccgccg gagatcctgc ccgacgagcc gatccggacc agtgacctgc cgatgctgcc
     3601 gctggtggtg cccagctacg gcttgatcac cgacttcctc cggggctggt tcggtcccga
     3661 atacctgctc cgcctggaga tcgccgccga gatcgacacc gtgcactacg gtttcgagct
     3721 gcttcgttcg cagctgaccc ggggttgcat gctggtcacc caggggatcg gcgaggccgc
     3781 cgcgcagggc aggctgccgg agggcgacaa tttgcggacc atcgagctcg tcgacgacgt
     3841 ggcacccggc ctgcaggtgc tggccggact gttcgcccgc cgggacgagc gagccgccta
     3901 tcccgacgac catccgctga atctgatgtg gtccgcgttc gcccgccagg acatccagta
     3961 caagcgcagg cgtaccgaca ccgacaccgg ctccgaggac gcgggttgaa cacggaccaa
     4021 gatcgaagca ctgcccgtgg cgcggcaacc cggataccgt cgtcgacatg actgcactcg
     4081 gggatacccc gcgtcgaatc gtggtcgtcg gatcgtcggt ggccgggttg accgtcgtcg
     4141 acaccgtgcg ccgcaacggc ttcgacgggg cggtgacgct gatcggcgac gaggtccacc
     4201 ttccctacga ccgaccgccg ttatcgaaac aggttctcgc gggcgactgg gacccggaac
     4261 gggttcggtt gcgctccgaa tcggagctgc acgacctcga cgtcgacctc cgcctcggca
     4321 tcgccgcgat tggtctcgac ctggcgcgac gtcgggtgac actggccgat ggcggcgtgg
     4381 ccgactacga ccggctcgtc gtcgccaccg gggtcgcccc gcgtcgactt cccgacaccc
     4441 acggcgttcg aggggtgcac accgtgcgca cggtcgacga cgtcatcgcg ctgcgcaccg
     4501 agatgcgccc ggatgctcgg ctggtggtgg tgggcgcggg cttcctcggc accgaggtcg
     4561 ccgcctcggc ccgtcggctg ggcgcgcagg tatgcctggt ggacccggca ccgactccgt
     4621 tggcggccgt ggtgggcgcc gaggtcggtg gtttcgtggc gcagctgcac cgggagcgcg
     4681 gggtggatct gcggaccggg cctgccgccg cggtgcgctc gctgcaggtg gtcgatggcg
     4741 cggtggccgg ggtcgaactc gccgagggcg acatcgtgcc cgccgacgcc gtggtcgtgg
     4801 ccatcggttc gcggccatcg gtcgactggt tggcgggcag cggcctgcac tgcgaggacg
     4861 gcgtgcactg cgatcccacc tgttcggcgg gctcgggggt atacgccgcc ggcgacgtcg
     4921 cacgctggtt caacccgcgc tacgacgtcg agatgcgcat cgagcaccgc accaatgccg
     4981 ccgaacaggc cagacacgtc gccaacgcga tgttcgccgc cgaaccggtc ccgttcgccc
     5041 ctattcccta cttctggtcc gaccagttcg acgtcaagat ccagtcgcac ggcctgctgc
     5101 gcgaccacga cgaggtgcgg ttggtctccg gctcgttcga acagcgacgc ttcatcgcgc
     5161 tctaccggaa gggcagccgg gtggccgggg tgctcggtgt cggcgacttc cgggggctgc
     5221 ggcggtggcg gaccgctctg gacaccggtg tcgaatgggc cgacgccatg gccgaggtct
     5281 agcagcgcgg acgtcgtcga gaaaatcggt gtcgtctgag caaagcagcg gggtagggtg
     5341 tgcgcgtggt cctcatgcat tccttctgca ggcttcgcgc cgcctgacct tcgccggtac
     5401 cgaggcgcgc cgtcgctcgg cgcgctcgac accgagccgt aggtaggccg ccggccgagc
     5461 catacccgca cggccgctcc agctcgccct cacccggcgc tggatgctcg atggccgttc
     5521 cacccatcgt ggtagtcggc ttcgtcggcg agcccgcctg cgatcagcag ctcttgctca
     5581 tatttcgctg catcggggcg tccacgcatg ccccggggga agacaggtcc atctcatggc
     5641 acagctctcc aaccaggccg ccggtcactc ggcagaccgc accaggcgga tcgacggcgc
     5701 gccgacctat gtgttcgtcc acgggtccgg ttccaactcc ttcatgtggg cgtcgatcca
     5761 acgtgaactg gcgctgctcg gtcaccgcag tcacgccgtc gatctcccgg gacacgggct
     5821 cgacgcggag tactcggcgt cctaccaggc accccaggat ctccaggcct gggcgaacga
     5881 accgtcgaag ctggccgagg tcaccctcgt cgacaacgtc gaggcggtgc tcgacgtcgt
     5941 gcgcaccgtg ggggcacacg gcccggtcgt gctcgtcggt gccagcctcg gtggcctgac
     6001 catcagcggc gtcgccgatc gtgcaccgga agcggtggct cgactggtct acatctccgc
     6061 gtggagctgc gtgcggttgc gcaatccact cgagtacatg gcggaaccgg agttcggcga
     6121 gaacctgctg gctccgctgg cggccctcaa cgtcggggat cccgcgcggc tcggggtggg
     6181 gcgggccaat taccgcacgg ccgacccgac cctgctgcct gcgctcaagg ctgccgtgat
     6241 ggccgatgcc accgatgcgc agttcctgac cttcctcaac atcctgcaac cggacgagtc
     6301 gctgcaggtg atggcgggag acgccacggt gcacgccgag acctggggca ccgtggcgcg
     6361 cagctacgtc cggctgctgc aggaccggtc gttgccggtg gccatgcagg accggctgat
     6421 cgcggaggcc gacgcgctga ccccggacaa tcgttacgac gtgcacaccg tggacagctc
     6481 gcacgcgggt ttcgtctatc gagcgcggga gatggcggca ctgctcgccg ggctgcccgc
     6541 ctgatcggat aactcgaagt tccaccgcac cgctgtcggg cgggatcacc aggtagacca
     6601 ggattgctct tggcgatacg gatcccgccc ggcagcgggc tacggctggg ttctgcgccg
     6661 tggtaatccg ttccaacggc gcctcggagg ccaggatgac gacgaaaccg gtaggggcgg
     6721 tgacccgccg cgcggtgctc ggtgcggccg cgctgttctc gctcgcgggc tgtgggggcg
     6781 acgagctgat cggtgccgtg acatcctcga gcccgggaga cccgccgggc gagcccgacc
     6841 cttcgactcc gagcagcgcc cccgctccga ccgaggtgag caggcggcac gatcggctcc
     6901 tcgaactcga gcgggagttc gatgcgcggc tcggtgtcta tgccatcgcg gtcggcaccg
     6961 gcaacacggt ctcccaccgc gcggacgagc gcttcgcctt ctgctccgcg ttcaagggat
     7021 tggccgccgc agccgtgctg caccggcatc cgatgtccta tctcgacacg gtcgtcacct
     7081 ataccgaggc cgatctcatg gccagctccg ccatcaccga gcagcacgtg gccaccggga
     7141 tgacgatcgg cgcgctgtgc gacgccgcag tccgattcag cgacggaacg gcgggcaacc
     7201 tcttactccg cgacatcggc ggaccggccg aactgacggc ctatacccgc agcctcggtg
     7261 acacggtgac tcggatggat cgctacgaac cgacgatcgt cgaggccacc ccgggcgatc
     7321 ctcgcgacac gacctcaccg cgtgccatcg gcaccgacta tcacgacatc gtgctcggcg
     7381 ccgccctgcc cgccgagaag cgggacttcc tgcgcgacct gttggagcgc aacgccaccc
     7441 tggcaggcga gcagcggatc cgggccgggc tccccgcagg ctggacggtg gccgacaaga
     7501 cggggaccgg cgattacggc accgccaacg acatcggcat cgtctggccg ccggatgccg
     7561 aaccgatcgc catcgccatc atgtccagca aggacgaacg cgatgcccgg tacgacaatg
     7621 cgctcttggc ggcggccacc gaatacgtgg tggacatgct cgcctgatcg agcagcatcc
     7681 gacccccgcc ggaccggtag ccgccgaagt tcggtggggg cacccggatg ccggtggcga
     7741 cggccgtgaa tgactcgatg gcgatcgccg gaccgccaag ggaatcaaca tggatccggt
     7801 gctatcgcat gaattgcttc accctttggt gacagatcat ggtgttactc tggtcggcgc
     7861 gttacgtcgg cgtgccgcct ccgtcgtcga tcttgaagcg ggagcggaat gtcgcgttaa
     7921 cctgggcgga atattgtaat ggtgaaggtt catcaagcgg ggagcgtcat gacggtgatc
     7981 attcatcttg tagagaacct gaagaggacg aacgcggcca gatgggggtg ctgccgccgg
     8041 ccgatcgggc ccggtaggaa gtgcggcgcc gcgatcggag agcgatgtat ttccagctgt
     8101 taggcgaagt tcgattctgg cggcagggcc gagtatgcga aatcggtcca caacaacgtc
     8161 gcctcctgct cgcagtcctg ctgttgaacg ccaatgagtc ggtccatcgg gaacgactgt
     8221 tcgagttgct gtggggcgat ccgctacccc gatcggcgac cggctcattg catgcccatg
     8281 tgtcgcgact ccggtcggcg ctgggcatcg cgggcggcaa ggcgatggcc gaggggatga
     8341 gcctgcggac cgtcggcccc ggctacctga tgtcgatgga accggaatgc atcgacgcac
     8401 accgcttcga ggcactggta ggacaggcca aggcggcgtc tgcgccggac gcggcgcggc
     8461 tctacgggca ggcgctcgac ctctggcacg gggagccgct gtccgacatc accaacgagc
     8521 gggcccgcct cgaattgtgc gttcccctgg aggaacggcg cctcgatatc ctcaccgcgc
     8581 agatcgatct cgaaatcgga ctgggtcatt ggctggagtt ggtagccaag ctgaccgaac
     8641 tactgaccag gtttcccggc aggccgagat tcgccgcgca gttgatgatc ttgctgcacc
     8701 gggcgggtcg caccgcggac gcactcgagg tattccggcg acttcgcgaa tccatggacc
     8761 gggatttcgg tttggagcct cctgaccgat tggcctggtt ggagacctcg atattgcgca
     8821 acgatccggt gttgcaacag aacgacttcg tgatcggcgg cgactactgg cgggtgacca
     8881 gcagatcagg gcaccgttca tagccgggca agacggagac aagggcgaca caagcgagag
     8941 tatttagcct gatatcgcat cccggagtga tgtggtctgg cgaatctcgc gggatgtcga
     9001 gtgtatcgat cctgtctgga ggagatcatc atgaatggtg agtccgtggt ggcgtacgaa
     9061 ccccccgcac tggaagaggt cggtgtcttc gacgaggtga cgctcggccg cccgggctgg
     9121 ggcttcgaag ccgactggac ctgcgtcatg ttgtgctgat tcgggcgaat aagcaccgaa
     9181 tgaccgcgtg agtacggccg tgccgatgtg tgtccccgcg cctcggtgcg gccgtgccgg
     9241 gtaaccaccg aagtccgcag gtccgcgcgg ctgggccgac tcgtgcccat cgacagggcg
     9301 acgatcgacc gagtctcaga acacggcgct tcctcgacgt ggaacggagt caccgtggtc
     9361 accaacgatg tcgccaccga gatcgagacc gatcgggaca gctcggacgt ccagcccgaa
     9421 cggggcaccg atctcgacgg cccagagccg caggacgcgg ccgacgatgt gcggtttcgg
     9481 ctgctgatgg ccggattccc gaccggggtc acggtgatca gcaccctcgg tcgcggccag
     9541 gctccgatgg gcatgacctg ttccgcgctg tgcagcgtga gcctgggccc gccgacgctg
     9601 ttggcctgtc tgcgcgcggg tagtccgact ctggcggcga tccgacgccg ccgggtcttc
     9661 gcggtgaacc tgctgcatga ggcggcgcaa cccgtcgctg agctgttcgg ctccggagca
     9721 cccgaccgtt tcgatcgggt gcgttggcgg atcgagcctt cctggggagt cccggtgttg
     9781 ttcgacgacg tgcacgccgt ggcgcgatgc cgggtcgtcg acagcaaact cgtcggcgat
     9841 caccgggtgg tcttcggcga ggtcacccac atccggcact acgcggagat ccgcagtccg
     9901 ctgatgtacg ggcggcggcg gtacgcgggc tggcccgcag gctgaaaccg atcgaaggcg
     9961 ctgccatcgc ggtcatcgat ccccgagaac gggagcagaa gtggagtttg tgatcctgcc
    10021 ggactgtcca cagggcacct ccgtcgcgga atcgatcggc ggagccggaa caacggtggt
    10081 cgagcacccg tcgggcaggc cgtggatcgt cggacgctgg tcgccgggcg agatcgtcgc
    10141 ggcctcggcg ggcaggcacc gaatcgtggc cctgggaatc gccgcgacta cggccgagga
    10201 cctcgccgcc cggctgggac ggatccgcga cctcggcgaa ctggatcgca tccgcagcgc
    10261 gctgccaggc agttatcacc tggtcgcctc gatgaacggc cgggtcgggg cgctgggcac
    10321 tctgtcgacg gcacggcaga tcttccacac caggatcgcg ggtgtggtgg tggccgccga
    10381 ccggccgcag agcctcgcgg cgctgtccgg ggcctgcctc aacgaggaat tcctcgccct
    10441 gcagctgatc tcgccctatg caccctggcc gctgagcgac tacaacccat ggcgccgggt
    10501 cgaagcgctg tccgcagggc accgactcga gctggatcgg gacggctccg gccgagaggt
    10561 gcgctggtgg cgacccccgg ctcccgaggt gccgctcacc gagggcgccg agcgggtgcg
    10621 cgccgccttg cacgacgcgg ttgccgcccg cgtcgcgacc gaacggccgt tgagcaccga
    10681 tctctccggc ggaatggact ccaccagcct cgccttcctc gccgccggac aggtcgatcg
    10741 attcgtcacc acccgttggc aggcgacgaa tgtggacgac gaggaccaga actgggccca
    10801 gcgcgccgcc gcctcgattc ccaacgccgc gcacatcgtg ctcgaacgcc agggcatccc
    10861 gatgaacttc gcgggcctgc tggccggcga tcccgacatc gaggcgccct tcgcctggat
    10921 ccggacccgc gaacgcctcg cgttccaggc cgggcggctg gccgaactcg gctccacgat
    10981 gcacctgacc gggcacggcg gcgacgagct gttcttccct actccactgc agctgcacgc
    11041 cctgctgcgc agccaaccat ggacagccat caaatacctg cgcggattcc gctcgatcta
    11101 tcggtgggcc ctgcccgaca ccctgcgtgg gatcgcggcc gaccagagct tccccggctg
    11161 gctcgccggt tccgcagcga ccctgaccga ctcggtccgg ggggtcaatc ggacgccgaa
    11221 cttcgggtgg tggggccagt tccgcacccc gccgtgggtg actcggacag gcgtcgactc
    11281 ggtccgggag ctactggccg atgccgccgc gaagaccccc gagccgctga gcccgattcg
    11341 cgcgcaacac gccaccatcc aggacatccg caagtgcggc gagtcgattc gccgggtcgg
    11401 caggctcacc gcgcggcacg gcgtcgactg gcaggcgccc ttcgtcgacg accaggtggt
    11461 cgaggcggcg ctatcgatcc gcttcgccga ttccgcctcg ccgcaccggt acaagccggt
    11521 gctggtggag tcgatgcggg gcacggtgcc caccgaggta ctggggcgcg gcaccaaatc
    11581 cgagtacagc gccgatgtgt acgccgggct gcggtcctgc cgaggagaac tggccgaact
    11641 ctgcgacgac atgctcctgg cccagcgcgg cctcgtcgac gccgaccggt tccgcacgac
    11701 gctacttggt caacacacct cgtccgcagg gttgagtctg gtggtcgcga ccttggcctg
    11761 cgaggtgtgg ctgcggtcgg tggccgcgtt cgcgcccacc gctgtcctga caggaggagc
    11821 acgatgacct tcactctcgc gccggacgtg tcgctgaccg acgtcggcga ctcgatggtg
    11881 ctgctggacg agaaaggcgg ccgctactgg cagctcaacg cgaccggggc gatggtgttg
    11941 cgtcgactgt tggcgggcgc ccaggtcgcc gagatcgtcg agacgttgag cgagcggcat
    12001 cccgccgccg cggatcgagt ggcatcggat gtcgaagcca tcatcgaggc gttgcgtgct
    12061 gcgaaggtgg tcacccgatg acgatgccgg tgatgctcga accatcggtc gacgtcggca
    12121 tgcgacgtcg agcagccgcc cgggtcgctg tggcggcgtc ctggctgttg atccgcctct
    12181 caccccgcag gctccgacgg gtcctcgaag tgttgcgacg tggtgcccga cccgccagcg
    12241 cccggcagat cacgatggcc aggaatgcgg tggtggcggt gagcgtgcgc tgtgcgggcc
    12301 agggctgtct gcaacggtcg gtcgccacgg tgctgctggc ccggctcggc ggtcgttggg
    12361 cggactggtg caccggtgtc tgcatcgagc cgttccgcgc ccatgcctgg gtcgaggtcg
    12421 acggcgttcc gatcggtgaa cgcgacgacg tcgcaggcta tcggaccatg ctggccgtgc
    12481 gttgtcgctg atcagggcgg cggtcatccg cgaggagagg acaccggatc catgacgagt
    12541 tacgtgctgc tggcggatcg attcctgatc gccgtcgtct tcggcgtcgc attcatcggc
    12601 aagatcgcgg gtgcgacggc cttccggcag ttcgcggcga cggtgcggca gctgacgaga
    12661 ttccccgaac ccgtggtgac gggcatcgcc gcgttcatcg tcctcggcga ggcggcgacg
    12721 gtggccctgc tggtgttgcc tggcaccacc ggttgggggt tcaccctggc gatcgggctg
    12781 ctggtgttgt tcatcggcgt ggtggccagg gccattcagg cgggtgtgct ggtcgagtgc
    12841 cgctgcttcg gccgtggctc ggtgatgacc agcgcgatga tcctgcgcaa tctgttgatc
    12901 attgctgtcg ccgtgatcgg actcgtcttg agcccgggtg aaccgatcgg ggacctcggc
    12961 tacgccgcgg tggcggcgct cgtcggtctg gcgggtgcgg cgttcttcat tcgctattac
    13021 gacgcgctgg tacgcgtggt gctcggtcgg ctggctccgc aggtcgaggc gtgaccggcg
    13081 ccccgcgaac cggctcgccg gacctgatga tcgaggccat cggcctcggg aagcggttcg
    13141 gcgaggtggc cgcactgacc gatgtcgatg tggcggtgcc gagagggacg gtgctcggtc
    13201 tgctcgggca caacggcgcg ggcaagacga cgctggtcaa catcgtcgga accctggccc
    13261 ggccgagttc gggaacggtc cgggtcgccg ggtacgacgt ggtgcggcag gcctcgcagg
    13321 tgcgtagccg gatcgggctg accggccagt tcgccgcgct cgacgaacgc atcacgggcc
    13381 gggacaacct ggtactggtc ggcagactgc tcggtgcgtc gcgccgcgat gcgcggcggc
    13441 gggccgacga actcctggag ttgttcgggc tcaccgccgt ggcccaccgg ctggccaaga
    13501 cctactcggg cgggatgcgg cgcaggctcg atctcgcgat cggtctggtc ggccacccgg
    13561 aggtcatcat tctcgacgag ccgacgactg gaatggaccc gacgagcagg ctggacctct
    13621 ggcagaccgt gcgggagatg gtgcggcagg gcagcaccgc cctgctcacc acccagcacc
    13681 tggaggaagc cgaccggctg gccgactcga tcacgctgct ctccggcggc cgcgtcgtcc
    13741 tgtccggaac cccgacggaa ctcaaggccc gggtgggcag gcgggccgtc accgtgcggc
    13801 tcgcccgcga cgaggtgtcc tcggccgtac cggcgctgcg ccgggcaggg ctgcaaccgg
    13861 tgcggtccga tagtcgggac accgagttga ccatcgcggt cggacagtcc cgggagatca
    13921 cctcggtggt ccgtgcgctg gacgaggtgg gcatcgaggc ggccgagctc gggatcaccg
    13981 agccgggcct ggacgaggtc tatctcttcg tcatggacaa cgccgttgcc gatgcccgct
    14041 agcgggtcgg ctcggaccga cacggtcggc gcgacgcaga acaggaggcc ggcttgatgg
    14101 ccgtggaccc gcagggacgt gtcggatcgg cgatgcggga ggcgacggcc gccgtcgtcg
    14161 acccgcctgc cgcgcgggaa cggcggggaa cgacgctgcc ggatcaggtg ctcgtcctca
    14221 ccggacggtc gttgcgtgcg gtgctgcgcg atccgaggtt gatcctgacc aacctgttgg
    14281 cccccttgct catgctggtg gtcttcagcc agatcttcgg tagcgtcgcg cagactcccg
    14341 gctttccggc gggcaccgcc tacatcgact tcctggtacc cgcgatcctg atcaacacca
    14401 ccctgcaggc tgcggtgagc agcgcgttcg ccttgacgag cgacatgacc tcggggatcg
    14461 tcgcgcggct gcgctgccta ccggtctggc ccggttcgat cctgctggcg cgcagcttcg
    14521 ccgatctggt gcgcagtgcc atccagttac tgctgatcct ggtgttggcc acggccctgc
    14581 tcggtttccg cccgccgggt ggggtgaccg ggacgctcgc agcctgggcg ttggccctga
    14641 tcgtcggcac cggcctcggt tggatcttca tcgcggcggc ctgcaggatc cgcgaggccg
    14701 agttgatgca gggcgccgcg accctgctga tgttcccgct gatgttctgc tccaccgcct
    14761 tcatgcccct ggcgggcctg cccggctggc tgcgggccgt cgccgaggtc aacccgatgt
    14821 cctacggcat cgacgcggcc cgcgcgctgg tgctcggcca gccggtgggc gctgcggtga
    14881 tcaccgccat cgggatgagc ctgctggtcg gtggcgtggc cggggtgttc gccgtccgag
    14941 cattccgccg cccgatctag cggcgcagcg gcgggagctc gaatccgccc acggtgttct
    15001 cacaccgcga cggcggcccg gtccagcgcg taggcctcgg cgagcaacgc gtaggaccga
    15061 cggcggtcct cgaagccggc gacctgcgtc gtgaccatca cctcgtcggc gcccgattcg
    15121 gcgacgaccc gatcgatacc ggcccgaacg gcctcgggag taccgacgaa ccggcccgca
    15181 gtctgtttgg ccaccagcgc gcgttcctgg tcggtgtagg agtactcggc cgcctcgctg
    15241 atcgagggca gcggtcgatg ccggtcgccg gtgcggagcc ggacgtacaa cagcgcggca
    15301 ggtgcggcca gtcgttgcgc ctgggcatcc gattccgcgc acaccgcgcc caccgcgatc
    15361 atcgtgtgcg ggacggagga cagcccactg gggcggaacg ccgatcggta tgccgccaat
    15421 gtcgagccga cgttctccgg agcgatgtgg tgcgcgtagg cgaaggacag cccgagcatc
    15481 ccggccagct gggcgctgcg gggaccgacc ccgagcagcc acaactccgg tcggtgtccg
    15541 acggcgggaa tggccgacac cggggtacct gccccctggt tctgctgggg cgcaccgaag
    15601 aagcggacca gctcaccgag ctgcccgggg aactcggccg catcggtgca gcgcaacgcc
    15661 gccgcgaccg cctgatcggc ggcgggggcc cggcccaccc ccagatcgat ccgttgcgga
    15721 tgcagcgctt cgagggtgcc gaattgttcg gcgaccacca atggctggtg attgggcagc
    15781 atcacaccgc cggaacccac gcggatccgc tcggtgaccg cggcgacggc ggcgaccagt
    15841 accgaggggg agcagctggc aacgctggcg acatcatgat gctcggcgaa ccaatagcgg
    15901 tcataaccga gctgctcggc ctcccgagcc agccggacgc tgccgcgtaa cgcatcggcc
    15961 gccgtcgaac cggcgccgat cggagcgaga tcgagtacgg acagcggtac ggacgccgaa
    16021 gccatgaatt ccctttcgcc gggagcggtt ggggccggat accagagaac tccgcaacgc
    16081 tacggcggcc tgcttgcgcg tttcttgccg cagacttgcc ggtttcctgc ttcagtcacg
    16141 ctgcctggac gtttccggga cacgccgggc aagcgtcgaa caagccacgg gcaagatctg
    16201 ctggttagcg tcgtattcca cccgcgacac aaggcgctgt cccagaacag cgcggcggaa
    16261 cgcgaacagg ggaattgacg cgatgacaca ccagctggat cggcgactac tgctgcaatc
    16321 ggtgaccgcg ttgggggccg ccgcactcac gggactcacc gcaggtcgat cgtatgcgca
    16381 gccgcaggcg caactcgatg gcgatttccc gcccgtgcca ggaatgcgag gcgatcggcg
    16441 cgccaacgag atgtggtatc acctggacga ggtcaccctg ttcaatcgga ctcccgaggt
    16501 cgaacaggcg tatgcggagc tttacgaggt cttcggtgac ggcttcatgc agttgctctt
    16561 cgacacttgg agtcggttga gcggcacgcc ggactacgag accgagttca ccgagttcgt
    16621 caccccgatc cgtgctgcgc tgcaggcatt ctcccgggtg cagctggaga tcctcgatct
    16681 ctactacctg ccgaacgacc cccgcttggt gacggccttc gggtctttcg gccagggcat
    16741 cctgttcgac cctcgccggg ccggggtagg accgcaggtg cacatgatgg atggcgagga
    16801 gacgatgagc taccacctct ggcacatctt cctgcgcgcg atgatgatgc tcgacatcga
    16861 tcgggctcgg tgggcccgcc tcgatccatt gatcggatac gcctgggctc tgcaatcgct
    16921 ggccctgccc gattccaatg cgatcaaccc gccgctgccc cgcgagaccg ttcgaggctt
    16981 ggcgggcagc tggttgccgc gctccccggc ggagctggac cggtccttcc gcagcttccc
    17041 ctatcccacc gattgacccc ggcgcttcgt cactgcggca gtccaacgca gggcataacg
    17101 gggtgcaaca ggtcgcttca tcacctctaa tagggcagga gagggaagtt tagggagtga
    17161 tacggtagtt cgcatgtccg aggagctgct cacagcggac gaggtcgccg cccggctggg
    17221 actgcacgtg cggaccgtgc gcaactacat ccgcgacggc agactgcccg cggtccgcat
    17281 cggcaagcag taccgcatca ccggcgccga tctcgcggag ttcctcggca cggccccgga
    17341 gctccgcgac gaaacgccgc cgtcggcggg ggagcggcat gccgccgtgt cgagcatcgt
    17401 cgagatcgac gccatcgacc gcgccatggc cgaccggatc accacgctgt tgagcgccgc
    17461 gaccgcccac cgtcgtccgg gcgacgacca cctgcgcatc gacacggtgc acgacgcccg
    17521 tcgagcccga ctgaaggtcg tcatgctcgg cagcctgacg accaatgcgc atctgctggg
    17581 actcatcagt gcgctggtcg aggagggcga cgaatgaacg cgatctaccg ctccgaggcg
    17641 ggagcccgac tgctacggga gaagtatgcg gcaacactgg agcactggcc gattccccat
    17701 gaacgacagc acgtgccgac ccccgaaggg gctaccttcg ttatctccgc aggtccggag
    17761 gttgcgccgc cgctgcttct gctgcatgga tccgggagca acagcaccca gtggatgggt
    17821 cgcatcgccg aactcgccgc gcatttcagg gtgtacgcgg tcgacgtgat cggcgagccg
    17881 gggttcagcg caccggctcg gccgccttgg aagtcgagcc ggtataccga gtggctcgac
    17941 gccgtcctcc actcgcttgg catcgcgcag acgtcgatca tggcgatctc actcggcggc
    18001 tggctggcgc tggattacgc cactcggcat ccggatcggg tcacccggct ggccctgtcc
    18061 tgcccgatcg gcatcggcag acaacgcccg ggcttcctgt tctccgcact ggtatcgaac
    18121 tcgctcggcg agcgcggcag acgtcgcaac gtggccagga ccctcggccc ggtcctcgcg
    18181 accatggatc cggagcacgc ggacgccgtc atcgaacaga ttctgttgat ctcggcgaac
    18241 taccggtttc ggagcgattc gctgccggtg ttcgacgatt cgtccttgcg cagcctcacc
    18301 atgccgatgc acgttctggt aggcagtgcg gacgtcatgg tggattccgc gcagacccag
    18361 cgtcgactcg cgcgcaacgt gccacacgcc accgtccgtg tgctgccgaa caccggacat
    18421 ctcatcggcg accaagggcg aatcgaactc gactttctgt tgcattccga gccaagggag
    18481 gcatcgtgat cgacaccgcc tggggtgtcc gggcctacac cctcgacgcc gagggcgtcg
    18541 cgatcggaac cgaacgcgat gcgaccgacc tcatcggcga actctgggag ctcaagccgg
    18601 aactggtcgt catcccggtg cagcggttcg tcgacggctt cttccgtctg gagaccagat
    18661 tggccggtga tttcacccag aagctggtga attacggctt ccggctggcc atcctcggcg
    18721 acgtgtccga gcacatcgag cggagctcgg ccttcgcggg ttacgtccga gaggccaatc
    18781 gagggcggca tatctggttc gtggccgacc gcgacgaact ccgtcgacga ctgcagccgg
    18841 accggtgaat cagatctcgc gcggccggat cagatcggaa ccagccgggc gtcggcggcc
    18901 gtcctggccg atgggatacg gacctccacg accagaccac cgccgtgccg tggccgtgcg
    18961 gtgacccggc cgccacagga ctgggcgatg gtgtgcacga tcgacaggcc cagcccggcg
    19021 ccatcggcct gcccggcgcg aaccgcaccg cgatagaagg gctcgaacag ccgatcgacc
    19081 tcgtcggcgt cgatcggcgg cccggtgttg gcgatcctca gaacaccctg tgagtcgagt
    19141 tccacccgca cctcgccgcc catgatgttg taccgcaggg cattggcgac gagattgtgg
    19201 accagctggg cgagtagcac cggctcgccc agcacgacac atcgttcggg aaggtcgaca
    19261 tggagtcggg gcccgtcggc ggggacaccg gcgcccagtt cgtcggtcac ctcgtcgacc
    19321 acggcggcga gttccacggg ctcccgccga tgctgatcgt gttctcccct ggccaatgtc
    19381 agcagcccgt tgatcaacgc gatgcaccgg tcgttgttcc gcagtagatc ctcgcggacc
    19441 cggtcgatcc ggcccggatc cctggtggaa agcccgacct gcagcatcgt ccgggccacc
    19501 gcgagcgggg tgcgcagttc gtgcgatgca ttggcgatga atcgggcccg ggcggcgaac
    19561 gagttctcca aacgggcgag cagcgcgtcg aaggtgtcgg agagttcctt gatctcgtca
    19621 tccggacccg tcagcgcgag ccgctcatgc aggttcgcca tggacagccg ccgtgcctgc
    19681 gaggtcatcc ggtggacccg ccggagcacc cgcccgatgg cccaccacgc caacagaccc
    19741 gcgagcgcgg tcatcgcgat cagcgcgagg aaccattgcc cgagcaggtt tgccaacgcc
    19801 tcgttgcgct ggatcgcgat cccatcggcc agctcggtca catcctcggg ggagcgaccg
    19861 gtttccccgt gaacagccga tatcgggcgg tcctcggcat cgggtgcccc gatgcgcatg
    19921 atgatgaggc gattctggaa atagaccatg gtgagcacca ctgccgtgac gaccaggaac
    19981 agcgcggtgt tcagcagggt gagccgccat cgcagggtga gcctgctcag cacccgctgc
    20041 cacccatccg atatccggcg ccgggcaccg tctcgatggc gccgaccgcg ccgatcttgg
    20101 cccgcaatcg acacatggtg acccgcaccg cattggtgaa gggatcagcg tgctcgtccc
    20161 acaccacccg tagtagctcc tcggcgctga cgatccgccc ggcggcggcc atgagcacgg
    20221 acagcaatcc gaactccttg cgggacaggg cgataggcct gccattgcga gtgaccgagc
    20281 gccgagacga gtcgaggacg atgccgtgcc aacgcagcat cggcggcacg gcgggccctg
    20341 ctctgcggcc gagtgcgtcg agccgggcga cgagttcgtc gaagtcgaag ggcttgccga
    20401 gataatcgtc ggcaccgagt cgaagaccgg cgatccggtc gccgacgtcg gccatcgcag
    20461 tgagcatcaa cacacgagtc cggccgtcgt tctcgatgag ataccggcag atgtcatcgc
    20521 catgggtgcc ggggagatcc cggtccaaca ccacgacgtc gtaagcgccg gtcgtgagtt
    20581 tatcgagcgc ggtgtcgccg tcgaaggcca gatcaaccga tatcgattgg tcgcgcaacc
    20641 ccatcgcgac atattcggca agggtcttct cgtcctccgc gaccagcacg cgcatcgtca
    20701 tctccgctcc tggatatggc tacctcatgg gacggtaatg cggtggatgt tgtgacgaca
    20761 taagcactat ccggcccatt tcagggtgaa atgccggtga aacatcgcgg tccctacgtt
    20821 gtgcgctgca ctgctcagaa cggaggaaca cgaatggcga tcagaaccag ccgaggccgg
    20881 cgtggtgcca tttccggcat gggtctcgtg gtcggagtaa ccctcgggtt aggtacggtg
    20941 gccaccccgg tcgcggcggc caccgagttg gacgagttct acaaccagga ggccgattgg
    21001 cagcaatgcg aggagcctcc gccgccgctt cccgaggagg aacacgagga cagcatcatc
    21061 gtcgaccctt ggaagggtca atggaaatac atggaatgca ccacggtgag cgttccgttg
    21121 gattaccaga accccgatgg tgacaccctc gaactcgacc tcagtagaat caaggcgacc
    21181 gatccggaca gtcgaaaagg cgtgctgctg ttcaatcccg gtgggcccgg cggaggcggg
    21241 ttgtcgatgc cgctgggagc ccgcgagttc gaggtcgccg cgcatttcga tctgatcggc
    21301 ttcaaccccc gaggcgtgag ctacgcggac cgactcttct gtgaacgggt gacggatctc
    21361 ccgcccaggg tcacccgccc gaccgacgag cagttcgctg ccttcaccga gtacgcgcag
    21421 gagaaggaag ccgcctgcga acgggagagc ggtgatatcc gaccgttcat caacaccgcc
    21481 aacacggcac gggacatgga cgtcatgcgg gcagtgctgg acgaggagaa gatcaactat
    21541 ctcgggtact cctacgggac gtacctcggc gcggtctacg gcagcctctt cccggagcac
    21601 ctgaaccgca gcgtattgga ctcctctatc caccccgact ggttgtggcg ggagcaattc
    21661 aaacaacagg ctgtgggcgt ccggttcaac gtcgagcagt gggcgggctg ggtcgccgaa
    21721 cgcgacgaca cctatcacct gggcaccacg atggcggagg tactggagac caccgaggcg
    21781 ctcaccgctg cgctggccgt cgagccggtt gaactgggta tcgaacggcc ggaggactgg
    21841 tacaactact ggccgaccga ggccgacgga accgcgatcg accgcttcct gggcatgggc
    21901 gcgatgaccc ggccgacctg ggacgtcgtc gccgaggtga tcgtggagct gcggcaggcg
    21961 gccgaaggcg gtaccgagct gtccgccgac accggcaccg ttatcgggct gttgtccgcc
    22021 gacgacaccc gcaagatcga cccgggtgtc tacgacacgg tcacctgtga ggccgactgg
    22081 cccgccgacg tcgagaccta ctacgaggac atgcggcatt accgcgagca gtacccctac
    22141 gcggacttca acggcgcggg cgtcatcggt gccgcaccga ccaactgcac gttccgcagc
    22201 ttcgacccga tcgaggatct cgtggagctg gagcgcgacg gttaccccac cggactggtg
    22261 atccagggcg atggcgaccc cgccacccag tacgagggcg ggcccgcgat ggccgaacag
    22321 ctcgacaatc cgctgatctc cgtccgcgac accggcggac acgggttcta cggtatgaac
    22381 gagtgcgtga ccgagaaggt cgacgactac ctgatcaacg gcgagctgcc tgccgctgag
    22441 tccgattgcg cggaccagcc ccgccccgag gtccctgcgg acggtgccga g
//
