LOCUS       NZ_CP017157            21608 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces lydicus strain 103 chromosome, complete genome.
ACCESSION   NZ_CP017157
VERSION     NZ_CP017157.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lydicus
  ORGANISM  Streptomyces lydicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Complete genome sequencing of Streptomyces lydicus 103 and metabolic
            pathways analysis of antibiotic biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2016) Key Laboratory of Systems Bioengineering
            (Ministry of Education), Tianjin University, Tianjin 300072, PR
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001729485.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:23:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,288
            CDSs (total)                      :: 7,195
            Genes (coding)                    :: 7,061
            CDSs (with protein)               :: 7,061
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 47 of 134
            Pseudo Genes (incomplete)         :: 104 of 134
            Pseudo Genes (internal stop)      :: 11 of 134
            Pseudo Genes (multiple problems)  :: 26 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:52:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6776866
            Orig. end                         :: 6798474
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017157.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA is available from Prof. Ying-Jin Yuan.
            Annotation modified by submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21608
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="29"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..21608
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21608
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11608](-)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11608)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     misc_feature    complement(642..654)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     misc_feature    787..800
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            811..1548
                     /locus_tag="SL103_RS29305"
                     /old_locus_tag="SL103_29305"
     CDS             811..1548
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536131.1"
                     /locus_tag="SL103_RS29305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29305"
                     /product="response regulator transcription factor"
                     /protein_id="WP_069571994.1"
                     /transl_table=11
                     /translation="MDQTQTTQGGAAATPGAQRRVLVVEDDPTIVDAIAARLRAEGFQV
                     QTATDGPAAVETAEAWQPDLLVLDVMLPGFDGLEVCRRVQAQRPVPVMMLTARDDETDM
                     LVGLGVGADDYMTKPFSMRELAARVHVLLRRVERAALAAHTPRSGILRLGELEIDHAQR
                     RVRVRGADVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKALR
                     RKIGAERIRTVHGVGYALETPAA"
     gene            1545..2681
                     /locus_tag="SL103_RS29310"
                     /old_locus_tag="SL103_29310"
     CDS             1545..2681
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603144.1"
                     /locus_tag="SL103_RS29310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29310"
                     /product="ATP-binding protein"
                     /protein_id="WP_069571995.1"
                     /transl_table=11
                     /translation="MTRRHPSARRWWQPPLRELWQRAWEALRPLDPYRSVKAALGALVS
                     VSVIITTLLVFVAMRSATELRVITIFSIIASLLITQFVANNLTAPLGEMTDVTRAMAHG
                     DYSRRVRSERRDEFGDLAEAFNRMAADLEAVDTHRKELVANVSHELRTPIAALRAVLEN
                     VVDGVCEPDPETMRTALKQTERLGRLVEHLLDLSRLDNGVVPLHARRFEVWPYLSGVLK
                     EANMSRGASTLSGTGTHTRTDVHLHLDVSPPELTAHADAERLHQVVANLIDNAIKHSPR
                     HGRVTVHARRGDGPGSLVVEVQDEGPGIPESERYRVFERFNRGGPGTSGPGTDGGTGLG
                     LAIARWAVDLHGGRIGVAESSKGCRIRVTLPGREATRS"
     gene            2932..6723
                     /locus_tag="SL103_RS29315"
                     /old_locus_tag="SL103_29315"
     CDS             2932..6723
                     /EC_number="4.1.1.71"
                     /GO_function="GO:0004591 - oxoglutarate dehydrogenase
                     (succinyl-transferring) activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980415.1"
                     /locus_tag="SL103_RS29315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29315"
                     /product="multifunctional oxoglutarate
                     decarboxylase/oxoglutarate dehydrogenase thiamine
                     pyrophosphate-binding subunit/dihydrolipoyllysine-residue
                     succinyltransferase subunit"
                     /protein_id="WP_069571996.1"
                     /transl_table=11
                     /translation="MSLQSPNSSSISTEADQEGQGKSPAAAFGPNEWLVDEIYQQYLQD
                     PNSVDRAWWDFFADYKPGGATAPSAPAEGSPGAADAVLPPAAAPDRSAPAAPAQPKPAA
                     AAPATPAKPAASAPAPAKPAAAKPAAKPAAAKETEAPEGPEYVVLRGPSAAVAKNMNAS
                     LELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKVSFTHIIGYAMVQALKAMPSMNYS
                     FAQKDGKPTLVKPEHVNLGLAIDLVKPSGERQLVVAAIKAAETMTFFEFWQAYEDIVRR
                     ARDNKLTMDDFTGVTASLTNPGGIGTVHSVPRLMPGQSMIMGVGSMDYPAEFQGTSQDA
                     LNKLGVSKVMTLTSTYDHRVIQGAASGEFLRIMNQLLLGENDFFDDIFKSLRIPYEPVR
                     WLRDIDASHDDDVTKAARVFELIHSYRVRGHVMADTDPLEYHQRKHPDLDITEHGLTLW
                     DLEREFAVGGFASKSMMKLRDILGVLRDSYCRTTGIEFMHIQDPKQRKWIQDRVERPHK
                     SPEREEQLRILRRLNSAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAAESRLD
                     EVVIGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKYHLGAEGTFTGLD
                     GEQITVSLTANPSHLEAVDPVVEGVARAKQDIIGKGGTDFTVLPIQLHGDAAFAGQGVV
                     AETLNMSQLRGYRTGGTVHVVINNQVGFTAAPESSRSSMYATDVARMIEAPIFHVNGDD
                     PEAVVRVARLAFEFRQAFNKDVVIDLICYRRRGHNESDNPAFTQPLMYDLIDKKRSVRK
                     LYTESLIGRGDITLEEAEQALQDFQGQLEKVFTEVRDATTTPAVPEVPQPKAEFPVYVD
                     TAISQEVVKRIAESQVNIPEHITVHPRLLPQLQRRAAQVEDNTIDWGMGETLAVGSLLM
                     EGTPVRLAGQDSRRGTFGQRHAVLIDRETGEDYTPLLYLSEDQARFNVYDSLLSEYAAM
                     GFEYGYSLARPESLVMWEAQFGDFVNGAQTIVDEFISSAEQKWGQTSGVTLLLPHGYEG
                     QGPDHSSARIERFLQLCAQNNMTVAMPTLPSNYFHLLRWQVHNPHHKPLVVFTPKSMLR
                     LKAASSKTEEFTTGGFRPVIGDASVKAEDVRKVVFTSGKVYYDLDAERQKRGATDTAIV
                     RIERLYPLPGKELQAEIAKFPNAEKYLWAQEEPANQGAWPFLGLNLIDHLDLAVGADVP
                     HGERLRRISRPHSSSPAVGSAKRHQAEQAQLVAEVFDA"
     misc_feature    2969..2982
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     gene            complement(6816..9867)
                     /gene="fxsT"
                     /locus_tag="SL103_RS29320"
                     /old_locus_tag="SL103_29320"
                     /pseudo=""
     CDS             complement(6816..9867)
                     /codon_start=1
                     /gene="fxsT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603147.1"
                     /locus_tag="SL103_RS29320"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29320"
                     /product="FxSxx-COOH system tetratricopeptide repeat
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAEQSISVGSAGSSASSGPSGPAGSAAHITISYAGFARPWAAWIS
                     HQLEQQGHGTTLLRWDPKVDTALAEELSALLEAEGRLLMVLDDWYFRLGPKTQDEWTAA
                     LREVVPAARRPVRRGERGHPEPAGHRVPAAPRRPARPGRQRGQPPGPAPAGHRRAAADR
                     GRERPRRAPLPEQPARGVEHPAPQQPLHRPRQRPRRAVRQAGRARDDRGPAAGDPYRAL
                     RHLRRRQEPDRRRVRPPLRQRLRRGVVDQRHQPRRRPRTARRTRHPPRPPRRPGARRPH
                     PRRARGAAHRPPLPPLAADLRQRRRHGADRGPDPRRPRPRPDHHAHPRLVGLRQRPGDR
                     GTALQPRRVRRLRPSPRPPAHPGRGGHALRGRPGPAAAARPDRRLARRQPDVAQGVHRA
                     DPARRAQPRRHPDLLRLPDGLPDQLGHNSQHAARAQPRRGRTPQAVRLLRPRRHPRPDA
                     RQGPPRRPARTPRGPGRRTDQLEHRAAPADRVHRGTPRLPGLPGRRPGRGDRADAPALP
                     PVPAQRHDRGRARPDVGDRLPGAGHRRPAEPRRHPLLGALRRTHPAPGAGRRARQRRSG
                     GPAAAAQLRRVPAGPRRVPDRAAAVRTVHVPLAHPPRTHPAHHARAHPPARQHAAQTGP
                     LPRGRSGRQRRRRPARRRAGPLRRRPAARPGRPRRHPARPRLLRAGVRTLRRRLAGLHR
                     PPRPRGPAHALLAAQPRQRLRVARPLRGSAGHAPRGAGLPGAGAARTAPPHAQRGHRLR
                     PDAPAAGPLPRRRLQPGAQRPAAPPGDGRAHPADAARRAQPRAVLAPLRRGDQGRHADG
                     RRRRALPPGAGPAPPRNPHGPRRPRHLPARTRRPRPGPRPRRGGRRALRGAGRRAAPVH
                     RRHPGQRRAGPRRVRGDGGGAGPRRAGAARDDRDDGPRPPLDAGLRAQRRRGPQPGRRR
                     GRRGGAGPRHPGAGQGDARRPPSADALREDGAGRGPAGAAPPGPGGGEAGAGGDPAALR
                     DAGRRAPAHPLRPAPQAPVLGLRTAARV"
     gene            complement(10001..11182)
                     /locus_tag="SL103_RS29325"
                     /old_locus_tag="SL103_29325"
     CDS             complement(10001..11182)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087459.1"
                     /locus_tag="SL103_RS29325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29325"
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_208869985.1"
                     /sec_met_domain="PTHR43273 (E-value: 1e-79, bitscore:
                     267.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 1.9e-128,
                     bitscore: 427.2, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.1e-13, bitscore: 50.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGETTGRTTAVPFRQFVLKVHSRCNLACTYCYIYAGPDHSWRER
                     PRTVPPATVRQTALRIAEHARTHRLRDLRIDLHGGEPLLTGPGPLLAQAAAVRAALPAG
                     CTAEFGVQTNGTLLTRDTLDTLGAAGFRLGLSLDGGTPGLNRRRLDHAGRPSWPAVARA
                     VGLLHDRPDVFAGILCTIDITADPAEVYGSLRALDPPMLDFLLPHANWSSPPPATAGPG
                     PRPGPPVPAGRAPYGDWLCTVFDLWWDGGPGPRVRVFTEILGLLLGRPSTSEAVGLSPV
                     VALVVDTDGAIEQVDSLKSAYEGAAATGLNVFRHSFDEALAHPGMAARQRGRDALAPQC
                     RACALVEVCGGGNYAHRYRADAGGFTHPSVYCADLERLIRHIAARLDATVSLN"
     misc_feature    complement(11327..11340)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.36"
                     /tool="antismash"
     misc_feature    complement(11333..11342)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            complement(11390..11608)
                     /locus_tag="SL103_RS29330"
                     /old_locus_tag="SL103_29330"
     CDS             complement(11390..11608)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087460.1"
                     /locus_tag="SL103_RS29330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29330"
                     /product="YxD-tail cyclophane-containing RiPP peptide"
                     /protein_id="WP_069571997.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTPRTERAAAAPSGPSAEPLPDFAGVDVRLLAARTDHAVLGEV
                     ATLLLRNWPTGDEAVAYYEDGPGKLLR"
     gene            complement(11776..15219)
                     /locus_tag="SL103_RS29335"
                     /old_locus_tag="SL103_29335"
     CDS             complement(11776..15219)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603150.1"
                     /locus_tag="SL103_RS29335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29335"
                     /product="SAV_2336 N-terminal domain-related protein"
                     /protein_id="WP_069571998.1"
                     /transl_table=11
                     /translation="MPSGAPGPGPLDELVARLTAAGLPPDARAMADALWLAQWITPDAP
                     PGGPADAATDRTDRPDRTDPATFRVGPAGAADPARDGVPPASGSGPDASAGRPPSSRDG
                     ARRRVAELLPAQDERAADPDHHRLGEVAVPIASAFPGLLPLQRALRPVQRYRPPAAPAR
                     HTLDEPATAELSAHAETVIPVLRGVHRRAAALRLLMDGSSSMAVWEQMLHDLRQVCERV
                     GAFRDVTVHYLHPHGRDVGVAAAPGPGSPLRPADQLHDPTGHHLTLVISDCAGPLWRDG
                     RMQRLLYRWAADAPLAVVQPLPQRMWGRTLLPAVPGTLVRRQGPYQALDFLPARRRRRP
                     APAPAAPPGPPRERAVPVLSATPSALGSWARLAAADAGLSLRGAACVVRIDHGAEPAPG
                     PQDAPGGGEPSRMVRAFEQQASPAARLLAVHLSAVPLALPVIQLVQRAMLPQTGPAELA
                     EVLLSGLVTQLPPDVGAPPRSPGARGRPSDGQSTGTGPWYDFAPGVRDELLSRLSAGEA
                     ALILKHCSLYIERTFGRSARNFPAVAVAMLSGSGREPEAGQGVPAGGGPGSAVPAPFAR
                     VSERVLRRFEPALRPAGRRPYVPDGPAAEGAALLERYEQDRAVRDLIEAVRLLRAAADR
                     LPPAGTDLARALLHAWAKWGQPDALEEAERAARSATDAAGGDDAAGDTAGDAERTRALI
                     VRGRVAYARAGERRRAGTVAEERAALTDAARQLHTACGLMSLLDPRVLESMVLRTEVLR
                     RLAALSETPGATPGAGEDDAAAGADGPADPLDEAERSLTDLLDQWPSGEQVPGEVYAAR
                     GGVLLDQARRAARTRPEGPRPAEALAVRAADDLDTATVLLRRRGSAADRLVCETLLDLA
                     AARELNGGAGLPSVLPALERAREIARALDDPGLEADSLRRTAAAHRAVHTRTGALSALD
                     AAIAALAAALRLTAPDSPEHSSLLAERGAALLLRARLEPPGEPAKRLANEAVHVLREAL
                     ARVAPHDPDLGSHRLLFGRALRLRHERQPSLADLHEADWVLELAARGADVPDAVCAEAW
                     LEVGDVQLLLDRRFDSRERHDRAAACYRRAAAAAGRAGSALLAARAHHRRAGVLEVTAG
                     PRSALHAYRESWEQWQRAGEDAGPEAQRTRARMRALESTA"
     gene            complement(15225..16280)
                     /locus_tag="SL103_RS29340"
                     /old_locus_tag="SL103_29340"
     CDS             complement(15225..16280)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603151.1"
                     /locus_tag="SL103_RS29340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29340"
                     /product="MoxR family ATPase"
                     /protein_id="WP_069571999.1"
                     /transl_table=11
                     /translation="MSDWLIYRGAGAPHDGIEHLPPPPPWRDFDGGPLVAPPAALDPAS
                     ERRLGVQHREASHHRPGETERELVNAALYLRRPLLVTGAPGSGKSTLAHSVAYELGLGR
                     VLGWPVVSRSTLRDGLYDYDAIGRLQDLQIARAAPSAADSGAADGEDPTDEPGGGIGRY
                     IRLGPLGTALLPAARPRVLLVDELDKSDIDLPNDLLNVLEEGEFRIPELERLAGSAPEV
                     QVLSDDGARVTVRDGRVRCRAFPFIVLTSNGERDFPAPLLRRCIHLHIPAPDKERLAAM
                     VRAHFGEGAAERYEAVIDRFLDREPGDVRAVDQLFNAIHLTQKAGWTDQDEEETRRRLT
                     AELMRPLDRTR"
     misc_feature    16416..16429
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     gene            complement(16685..18835)
                     /locus_tag="SL103_RS29345"
                     /old_locus_tag="SL103_29345"
     CDS             complement(16685..18835)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603152.1"
                     /locus_tag="SL103_RS29345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29345"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_069572000.1"
                     /transl_table=11
                     /translation="MATPEGPAAGRGDRARYAQLLDLAGRTTVALRAAPPVPDAPLWGS
                     GVLIAPGWVLTCAHVLTASDGRRRATGPDGVFGVAFGGRVAPARLAYDLSRPDPQAGPA
                     ARADLALVRLLDPAPAHPCAWLSDQPATLLEDAYIFRGHERSGGSRPGERDIRESGAGC
                     GADRSAPPAAPVDPFIAVRFGARDARGLQFGSDVRVAPGASGGPLLDCDRGEVVGIVKG
                     RHQQDHVGLAVPVTALRGLGPEHLVEGASGAEDLGPDPYHALTGLHDRWHWAGQELGRA
                     GGPTWFDAQHAIMAGRGRLWGVQERLQALHLLARLPAPRDPLVVEAAVGEVLERGDGPG
                     AWALRTWRDGHGALYQGSDPYTELRAFVHYLRIVAQRCADAVRDAPDEQAAAVREDAAR
                     LAEFVQAKAVVLQPQDRRRIGPVRRRPRSVLVEFEPLFYDEGGHELYNWSVSEGYGRGQ
                     WLRVDVQEAAGGVPFEQAREQVLQRLGGRLLQADGDAGPGARVRLEVAVPEGRWHTAVG
                     QWEVAASPRRTARRRPVGPGRAVVLRDQGRRGQVDPAWLRRWQGLAAAPGLRALRLPPD
                     PGAGPRPGGGCTEAIWRLLETADQGALPALCHTVADGFGRDTVGAALDTGFPAALWPAR
                     GHGEERACDASCEEFHRGIRELLQGSGGVVRLPELVRQLRAKAAEAAGEGAHWARDLVL
                     LYDDPEDPIPQLFPDRPQVSPG"
     gene            complement(18835..19251)
                     /locus_tag="SL103_RS29350"
                     /old_locus_tag="SL103_29350"
     CDS             complement(18835..19251)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087463.1"
                     /locus_tag="SL103_RS29350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29350"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_069572001.1"
                     /transl_table=11
                     /translation="MHERAQRIEMPDGTEVWARVSRLDAAGLAGTDGSTDDFEDVGAWD
                     ALGARVEGLREVIGGVASSVRQAAARVAPDETSVTFGVELSAKPGKAVALLADGEAKTN
                     LSVTLTWRRDGGAPAPEEHRVPPPGIREPDDAGR"
     gene            19413..19592
                     /locus_tag="SL103_RS29355"
                     /old_locus_tag="SL103_29355"
     CDS             19413..19592
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889383.1"
                     /locus_tag="SL103_RS29355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29355"
                     /product="DUF6104 family protein"
                     /protein_id="WP_069572002.1"
                     /transl_table=11
                     /translation="MYFTDRGIEELENRRGEEEVTLGWVAEQLRTFVDLNPDFEVPVER
                     LATWLARLDDDEDE"
     misc_feature    19659..19674
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 25.23"
                     /tool="antismash"
     misc_feature    19659..19675
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 24.72"
                     /tool="antismash"
     misc_feature    complement(19660..19675)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    complement(19770..19783)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.35"
                     /tool="antismash"
     gene            19797..20717
                     /locus_tag="SL103_RS29360"
                     /old_locus_tag="SL103_29360"
     CDS             19797..20717
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603155.1"
                     /locus_tag="SL103_RS29360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_29360"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_069572003.1"
                     /transl_table=11
                     /translation="MSARTEWSQNPVQVTEPRTLEITEPVDALNVRVYGGTVNVVGTSD
                     RGPARLEISELHGPPLTVSCDGGVLTVAYEDLPWRGFLKFLDRRGWNRSAVVSVTVPAG
                     TRVEVGVVGATAVVSGISGDTDVRGVTGDSTLVGLTGAVRAETVSGNVEAQALTGDLRF
                     TSVSGDLTVIDGAGGGVHADSVSGDMVLDLDLTHAADINLTSVSGEIAIRLPDPANARV
                     EADTTTGTIANAFDALRVSGQWGAKKITGSLGAGSGTLKATTVSGGLALLRRPAREDGR
                     SGPDGPGAGPHEDSPTAPPAGKKVL"
ORIGIN
        1 ctcctccgca tccgacgacc ggtccggccc cggccccccg cacgctcgac cgccgcgagg
       61 gcccgtacgg cgaggtggtg ctgcggcaac gggacgggtc ccccgccggg cccggcgccc
      121 cggcggcccg cgtcgtctac gagatcatcg ccaacggctg cttcctgatg gacacctccg
      181 acggccgctc cgagcggctg ctggtcgacg ccgcgctggc cgcactgccg gccggccgcg
      241 cacggcccgc ggtgctgatc ggcggcctgg gcgtcggatt ctcgctggcc cgcgccgccg
      301 agcagccgcg ctggggccgg atcgccgtcg tcgagcgcga ggcggcggtc atcgactggc
      361 accgcacggg cccgttgtcc gacgtctcgg cggccgccct cgccgacccg cgctgcgaga
      421 tcctgcacac cgacctcgtc gcccacctgc gcgccgacgc gggcggggac acctacgacg
      481 cgctgtgcct ggacatcgac aacggccccg actggaccgt caccgagggc aacgacaccc
      541 tctactcccc caccggcctc gcggcctgcc acgaccgcct gacacccggc ggagtgctcg
      601 ccgtgtggtc cgcgcagccc tcgccggcat tcgaggaagc cttgcgaaat gccggtttca
      661 gcggggtgcg tacggaagag atcccggttg tccgaggcgt ccccgacgtg gtccatctcg
      721 cgcgcaaggg cgcgtagccg acagtcgcgc cgtgcccgta cgctgctgcc cagcaagacg
      781 cgaccacgca gggacatgca ggggcgggcg atggaccaga ctcagacaac gcagggcggc
      841 gccgctgcca cgccgggtgc ccagcgccgg gtgctggtcg tggaggacga cccgacgatc
      901 gtcgacgcca tcgcggcccg gctgcgcgcc gagggcttcc aggtgcagac cgccaccgac
      961 ggcccggccg cggtggagac ggccgaggcg tggcagcccg atctgctcgt cctggacgtg
     1021 atgctgccgg gcttcgacgg cctggaggtg tgccgccggg tgcaggcgca gcgcccggtc
     1081 ccggtgatga tgctcaccgc ccgggacgac gagacggaca tgctggtcgg cctcggcgtc
     1141 ggcgccgacg actacatgac caagccgttc tccatgcggg agctggccgc gcgggtgcat
     1201 gtcctgctgc gccgggtcga gcgcgccgcg ctggccgcgc acaccccgcg cagcggcatc
     1261 ctgcgcctgg gcgagctgga gatcgaccac gcccagcgcc gggtccgggt gcgcggcgcc
     1321 gacgtccacc tgacgcccac cgagttcgat ctgctggtct gcctggcgaa caccccgcgc
     1381 gcggtgctct cccgtgagca gctgctggcc gaggtgtggg actgggcgga cgcctccggg
     1441 acgcgcacgg tcgacagcca catcaaggcc ctgcgccgca agatcggcgc cgagcggatc
     1501 cgcacggtgc acggcgtcgg gtacgcgctg gagaccccgg ccgcatgacg cggcggcacc
     1561 cgtccgcgcg ccgctggtgg cagccgccgc tgcgggagtt gtggcagcgg gcctgggagg
     1621 cactgcgccc cctggacccg taccgctccg tgaaggccgc gctcggcgcg ctggtcagcg
     1681 tctcggtgat catcaccaca ctcctggtgt tcgtcgccat gcgctcggcc accgagctgc
     1741 gggtgatcac gatcttctcg atcatcgcct cgctgctgat cacccagttc gtggccaaca
     1801 acctgaccgc cccgctcggc gagatgacgg acgtcacccg cgcgatggcg cacggtgact
     1861 acagccgccg ggtgcgctcc gagcgccgcg acgagttcgg cgacctcgcg gaggcgttca
     1921 accgcatggc ggccgacctg gaggcggtgg acacccaccg caaggagctg gtggccaatg
     1981 tctcgcacga gctgcgcacg cccatcgccg cgttgcgcgc cgtcctggag aacgtcgtcg
     2041 acggggtctg cgagcccgat ccggagacga tgcgcaccgc gctgaagcag accgagcggc
     2101 tcggcaggct ggtcgaacac ctcctggacc tgtccaggct ggacaacggc gtggtgccgc
     2161 tgcacgcccg ccgcttcgag gtctggccgt acctgtccgg ggtgctcaag gaggccaaca
     2221 tgagccgcgg cgcctccacg ctgtccggca ccggcaccca cacccgtacg gacgtccacc
     2281 tccacctcga cgtctcgccg ccggagctga ccgcgcacgc cgacgccgag cggctccacc
     2341 aggtcgtggc gaatctcatc gacaacgcga tcaaacacag cccgcgccac ggccgggtca
     2401 cggtgcacgc ccggcgcggc gacgggccgg ggagcctggt ggtggaggtc caggacgagg
     2461 ggcccggcat ccccgagtcg gagcgctacc gggtcttcga gcggttcaac cgcggcggcc
     2521 cgggcacctc gggccccggc acggacggcg gtacgggact gggcctggcg atcgcccgct
     2581 gggcggtgga cctgcacggt ggacggatcg gggtggccga atcgtcgaag ggttgccgga
     2641 ttcgagtcac tcttccgggt agggaagcaa cgcggagctg acatcccggt tgacgtcacc
     2701 tgacgtaggg tcggtggtag gagcattcat cccatgggtg cgacggcggt aagtcctacc
     2761 cggacgcggg caaactacgt gtgtttcccg ccaagtcatg ccccgaaacc cgtcggggaa
     2821 tgtgacgtgc gtgacgagta gccctcccgg actgcaccaa aggtcacaag aggcgtagcc
     2881 tttattcccg ctgtccacca ccttaggaag cggaagaggg cggttgccgc cgtgtcgcta
     2941 cagtccccca acagctcgag catctcgacc gaggccgatc aagaggggca gggcaagagc
     3001 cctgctgccg cattcggccc gaacgagtgg ctcgtcgacg agatctacca gcagtacctc
     3061 caggacccga actcggtaga ccgagcctgg tgggacttct tcgccgacta caagccgggc
     3121 ggcgccaccg cgccgagcgc accggcggag ggctcccccg gtgcggctga cgccgtgctg
     3181 ccccccgctg ctgccccgga ccggtcggct cccgccgcgc cggcccagcc gaagcctgca
     3241 gctgccgcgc cggcgacccc ggcgaagccg gccgcgagcg ctccggcccc ggccaagccc
     3301 gccgccgcga agccggccgc gaagccggcc gccgcgaagg agaccgaggc ccccgaaggc
     3361 cccgagtacg tcgtcctgcg cgggccctcg gccgccgtgg cgaagaacat gaacgcctcg
     3421 ctggagctgc cgacggccac gtccgtccgc gcggtcccgg tgaagctgct gttcgacaac
     3481 cgcatcgtca tcaacaacca tctgaagcgc gcccgtggcg ggaaggtctc cttcacccac
     3541 atcatcgggt acgcgatggt gcaggccctc aaggccatgc cgtcgatgaa ctactccttc
     3601 gcgcagaagg acggcaagcc gacgctggtc aagcccgagc acgtcaacct cggtctggcc
     3661 atcgacctcg tgaagcccag cggtgaacgc cagctggtcg tcgcggccat caaggcggcc
     3721 gagacgatga ccttcttcga gttctggcag gcgtacgagg acatcgtccg ccgggcccgc
     3781 gacaacaagc tgacgatgga cgacttcacc ggggtcaccg cgtcgctgac gaaccccggc
     3841 ggcatcggca ccgtccactc cgtgccgcgt ctgatgcccg gccagtccat gatcatgggc
     3901 gtcggctcga tggactaccc ggcggagttc cagggcacct cccaggacgc cctgaacaag
     3961 ctcggcgtct ccaaggtcat gacgctgacc agcacgtacg accaccgcgt gatccagggc
     4021 gccgcctccg gcgaattcct gcgcatcatg aaccagctgc tgctcggcga gaacgatttc
     4081 ttcgacgaca tcttcaagtc gctgcggatc ccgtacgagc cggtccgctg gctgcgggac
     4141 atcgacgcct cgcacgacga cgacgtcacc aaggccgccc gggtcttcga gctgatccac
     4201 tcctaccggg tccgcggcca cgtcatggcc gacaccgacc cgctggagta ccaccagcgc
     4261 aagcaccccg acctcgacat caccgagcac ggcctcaccc tgtgggacct ggagcgcgag
     4321 ttcgcggtcg gcggcttcgc cagcaagtcc atgatgaagc tgcgcgacat cctgggcgtg
     4381 ctgcgtgact cgtactgccg caccaccggc atcgagttca tgcacatcca ggaccccaag
     4441 cagcgcaagt ggatccagga ccgggtcgag cgtccgcaca agtcgcccga gcgcgaggag
     4501 cagctgcgca tcctgcgccg gctgaactcc gccgaggcgt tcgagacgtt cctgcagacc
     4561 aagtacgtcg gccagaagcg cttctcgctg gagggcggcg agtccgtcat cccgctgctg
     4621 gacgcggtca tcgactccgc ggccgagtcg cggctggacg aggtcgtcat cggcatggcc
     4681 caccgcggcc gcctcaacgt cctcgccaac atcgtcggca agtcgtacgc gcagatcttc
     4741 cgcgagttcg agggcaacct cgacccgaag tcgatgcacg gctccggcga cgtgaagtac
     4801 cacctgggcg cggagggcac cttcaccggc ctggacggcg agcagatcac cgtctcgctc
     4861 accgccaacc cctcccacct ggaggccgtg gacccggtcg tcgagggtgt cgcgcgcgcc
     4921 aagcaggaca tcatcggcaa gggcggcacg gacttcaccg tcctgccgat ccagctgcac
     4981 ggtgacgcgg cgttcgccgg ccagggcgtg gtcgccgaga cgctgaacat gtcgcagctg
     5041 cgcggctacc gcaccggcgg cacggtgcac gtcgtcatca acaaccaggt cggcttcacc
     5101 gccgccccgg agtcgtcgcg ctcctccatg tacgccaccg acgtggcccg catgatcgag
     5161 gcgccgatct tccacgtgaa cggtgacgac cccgaggccg tcgtccgcgt cgcccgtctg
     5221 gccttcgagt tccgccaggc gttcaacaag gacgtggtca tcgacctgat ctgctaccgc
     5281 cgccgcgggc acaacgagtc ggacaacccg gccttcaccc agccgctgat gtacgacctg
     5341 atcgacaaga agcgctcggt gcgcaagctg tacaccgagt cgctgatcgg ccggggcgac
     5401 atcaccctcg aagaggcgga gcaggcgctc caggacttcc agggccagct ggagaaggtc
     5461 ttcaccgagg tccgtgacgc cacgacgacc ccggccgtgc ccgaggtgcc gcagcccaag
     5521 gcggagttcc cggtctacgt cgacaccgcg atctcccagg aggtcgtcaa gcggatcgcc
     5581 gagtcgcagg tgaacatccc cgagcacatc accgtgcatc cgcgtctgct gccgcagttg
     5641 cagcgccgcg cggcccaggt cgaggacaac accatcgact ggggcatggg cgagaccctc
     5701 gccgtcggct cgctgctgat ggagggcacc ccggtccggc tcgccggcca ggactcccgc
     5761 cgcggcacgt tcggccagcg ccacgcggtg ctgatcgacc gggagaccgg cgaggactac
     5821 accccgctgc tctacctgtc cgaggaccag gcccgcttca acgtctacga ctcgctgctc
     5881 agcgagtacg cggcgatggg cttcgagtac ggctactcgc tggcccgccc ggagtcgctg
     5941 gtcatgtggg aggcgcagtt cggcgacttc gtcaacggcg cccagacgat cgtggacgag
     6001 ttcatctcct ccgccgagca gaagtggggc cagacgtccg gcgtcaccct gctgctcccg
     6061 cacggctacg agggccaggg cccggaccac tcctcggccc gcatcgagcg gttcctccag
     6121 ctgtgcgcgc agaacaacat gaccgtcgcg atgccgacgc tgccgtcgaa ctacttccac
     6181 ctcctgcggt ggcaggtgca caacccgcac cacaagccgc tggtcgtctt caccccgaag
     6241 tcgatgctgc gcctgaaggc cgcgtcgtcg aagacggagg agttcaccac gggcggcttc
     6301 cgtcccgtca tcggtgacgc gtcggtcaag gccgaggacg tccgcaaggt cgtcttcacc
     6361 tccggcaagg tctactacga cctggacgcc gagcggcaga agcgcggcgc gaccgacacc
     6421 gcgatcgtcc gcatcgagcg gctgtacccg ctgcccggca aggaactcca ggcggagatc
     6481 gccaagttcc cgaacgccga gaagtacctg tgggcgcagg aagagccggc gaaccagggt
     6541 gcctggccgt tcctcggcct caacctgatc gaccacctcg acctggccgt cggcgcggac
     6601 gtgccgcacg gcgagcgcct gcgccgcatc tcgcggccgc actcctcgtc gccggccgtc
     6661 ggttccgcca agcgtcacca ggcggagcag gcacagctgg tcgcggaggt cttcgacgcg
     6721 taaggcgtcg ggccaccggt cgtaccggga ccgtcacaag ggcccgtccc cgctgctgcg
     6781 ggggcgggcc cttcggcgta ccggaaagcg gggcgtcaca cgggctgcgg ttcgaagtcc
     6841 cagtacgggc gcctgcggcg ccgggcggag agggtgtgcg ggtgctcggc gcccagcgtc
     6901 tcggagagct gctggatcgc ctcctgctcc agcttcgccg cctcctggcc ccggcggcgc
     6961 agcgcccgca ggtcctcggc cagcgccgtc ttcgcggaga gcgtcagcgg atggcggtcg
     7021 ccgagcgtca ccttggcccg ctccagggtg tcgcggccca gctccaccgc gccgtcctcg
     7081 tcgtcggccc ggctgcgggc cgcgccggcg ttgagcgcgc agcccagcgt ccaggggtgg
     7141 tcggggccca tcgtcccggt catcccgtgc agcgcccgct cggcgaggtc cagcgcctcc
     7201 gccgtctccc cgaactcggc gcggaccagc ccgacgttgc ccagggtgcc gacggtgtac
     7261 gggtgccgct cgccggccag cgcctcgtag cgctcggcga cctcctcggc gaggtcgcgg
     7321 gcctggccga ggtcgccgtg ttcgcgcagg aaggtggcgt ggtcggcgcg gaccatgagg
     7381 gtttcggggt ggcgcgggcc ctgcacccgg cgggagcgct cgacgacgtc ggccatcagc
     7441 gtggcggcct tggtcacctc gccggagcgg cgccagcaca gcgcgaggtt gtgctcggcg
     7501 cgcagcgtct gcggggtgtg cgcgcccatc acctggaggt gcagccgggc gttgagctcc
     7561 tggctggagg cggcgtcgcg gtagcggccc agcagccgga gcatccgggc gtaggcggtg
     7621 cccgcgttga gcgtgaggtg gtgccgtgcg cgcagctccc gctcccggaa ggccagcacc
     7681 tcgcggtgcg tgaccagcgc ttcctcgtag cggccgagca acgcgaagac gttgccgagg
     7741 ttgtgccgcg aggagagcgt gcgcggggcc tcggggccga ggaggtcggt gtaggcccgc
     7801 cagacggcgt cgaagagttc gtacgcctgc tcgtaggagc cgagggcgag cagggtgccg
     7861 gcgaggccgt cctgggcgcg cagcaggtcg gcgtcggagg ggtcccgctc ggcggcgagc
     7921 tggtcgacga cggcgctgcc gaccgcttcg gcctcgcggt agcggcccag tctgcgcagc
     7981 atgttggcgt gctggtgggt gagcacgagc atggtgcgct gggtgggttc gaggcgggtg
     8041 cgccagcggg acatgaactg ttcgcacagc cgcagcccga tccggtactc gccgcggacc
     8101 cgcaggtact cgacgcagtt gagcagcagc tgctggaccg ccggatcggc gctgtcgagc
     8161 acgccggccg gctccaggtg cgggatgagt tcggcgtagc gctcccagta gcgggtgtcg
     8221 gcggggttct gcgggtcggc ggtgaccagc acccggcagg cggtcgccga catcaggtcg
     8281 cgctcgtcct cggtcatgtc gctgcgcagg aaccggtggt agagccggtg catcagcgcg
     8341 gtctccacgg ccgggtcggc gtcctgggag acctggtagt cgaggcgtac cgcggtggac
     8401 tcggtcagcc ggcgcagcgc ggtgttccag ctgatcggtt cggcggccag gtccgcgagg
     8461 tgttcgggca ggtcgccgcg gcgggccttg gcgagcatcg ggacggggat ggcgtcgggg
     8521 gcgaagaagg cgaacagctt gaggagttcg accgcggcgg ggctgcgctc gcgcagcgtg
     8581 ttgagagtta tggcccagct ggtctggaag gccatcgggt agtcggagga gatccggatg
     8641 ccgacgaggc tgggctcgcc gcgccggatc agctcgatgt actccttggg cgacatcggg
     8701 ttggcgtcga gccaggcggc ggtctgggcg agcagcagcg gcaggtcctg gacggcctcg
     8761 gagagcatgt ccgcctcgac cggggtgagc cggggggcgc ggcgacgggc gtaggcgacg
     8821 gactcgacgc ggttgaaggg cagtacctcg atctcctggg cgctgccgga gcccgaccag
     8881 tcgcgggtga gcgtggtgat caggacgtgg ccgcggccgt cggggatcag gtcctcgatc
     8941 tgctccatgt cgtcggcgct gtcgaagatc agcagccagc ggcggtaggg gcggccgatg
     9001 cgcagcgcct cgtgcacggc gcggatgcgg tcgccgagct cccggccgac ggggaggccg
     9061 aggcgggtgg cgagttcggc gagctgttcg cgggcggcgc cgcggttggt ggcgctgatc
     9121 caccacacca cgtcgtagtc gttgccgaag cggtgggcgt actcggcggc gatctggctc
     9181 ttgccgacgc cggaggtgcc gtagagcgcg atacgggtct ccagcggcgg ggccgcggtc
     9241 gtcccgggcc cggccagctt gccgtacagc tcttcgagga cgttgtcgcg gccggtgaag
     9301 cggttgttgc ggcgcgggat gttccacacc tcgggcgggt tgttcgggaa gcggggctcg
     9361 ccgggggcgt tctcgtccac ggtccgcggc ggcgcgacga tgcccagccg gtgcaggacc
     9421 cggcggttgg cctcgttggc gtccaggtcg cgcaggtcgg cggggcgcag cagggacgcg
     9481 gtggccggca ggctctgggt ggccacgctc accgcggcga accggtcggc gtgcggcggg
     9541 caccacctcc cgcagcgcgg cggtccactc gtcctgcgtc ttggggccca gccggaagta
     9601 ccagtcgtcc agcaccatca gcagccgccc ctcggcctcc agcagcgccg acagctcctc
     9661 ggccagggcg gtgtcgacct tcgggtccca gcggagcagg gtcgtgccgt ggccctgctg
     9721 ctccagctgg tgggagatcc acgcggccca cggccgggcg aagcccgcgt agctgatggt
     9781 gatgtgcgcg gcggagccgg ccgggcccga cggaccggaa gaagcagaag aaccggctga
     9841 accaacggaa atggactgct cggccatgcg accgtctccc tgagatgcga tggtgcgcgc
     9901 gtgcggaggg tgagacatcg ggcacgccct ggctctttcg cacgatagcc caagtgtcgc
     9961 tccatatgac gacagtgcgt caggtcttct tgcatgcagg tcagttgagg gaaacggtcg
    10021 cgtcgagccg ggcggcgatg tgccggatga ggcgttccag gtccgcgcag tacacggacg
    10081 gatgagtgaa tccgccggcg tccgcgcggt agcggtgcgc gtagttgccg ccgccgcaca
    10141 cctccaccag ggcgcaggcc cggcactggg gggcgagcgc gtcccggccg cgctgccggg
    10201 cggccatgcc ggggtgggcc agggcctcgt cgaagctgtg gcggaagacg ttcaggccgg
    10261 tggcggcggc gccctcgtag gcggacttca gcgagtccac ctgttcgatg gcgccgtcgg
    10321 tgtccacgac cagggccacg acgggggaga ggccgaccgc ctcactggtg ctgggccgcc
    10381 ccagcaggag gccgaggatc tcggtgaaaa cccgcacgcg cggccccggg ccgccgtccc
    10441 accacaggtc gaagacggtg cacagccagt cgccgtacgg ggcgcggccg gccggcacgg
    10501 gcgggccggg ccggggcccc ggccccgcgg tggccggcgg cgggctggac cagttggcgt
    10561 gcggcagcag gaagtcgagc atcggggggt ccagtgcgcg cagcgagccg tagacctcgg
    10621 cggggtcggc ggtgatgtcg atggtgcaca ggattccggc gaacacgtcg gggcggtcgt
    10681 ggagcaggcc gacggcgcgg gcgaccgcgg gccaggaggg ccgtccggcg tggtcgaggc
    10741 ggcgccggtt gaggccgggg gtgccgccgt cgaggctcag gccgagccgg aagccggcgg
    10801 cgccgagcgt gtcgagggtg tcccgggtca gcagcgtccc gttggtctgc acgccgaatt
    10861 cggcggtgca gccggcgggc agcgcggcgc ggacggcggc ggcctgggcg agcagcgggc
    10921 cggggccggt gagcagcggc tccccgccgt gcagatcgat gcggaggtcc cgcagccggt
    10981 gggtgcgggc gtgttcggcg atgcgcaggg cggtctgccg gacggtggcg ggcggcacgg
    11041 tacgggggcg ctcgcgccag ctgtggtcgg ggccggcgta gatgtagcag taagtgcagg
    11101 cgaggttgca gcggctgtgc accttcagga cgaactggcg gaagggcacc gcggtggtcc
    11161 ggccggtcgt ctcccccgcc acggcgtcgc cccctgcccc cgtagaactc ggtcgcggta
    11221 cgggcccggc gccgtcggcc gtcacgtccc gcccgctgtc tggtacttgg ctccccgttc
    11281 gatcgaagaa tcgaattgcc gcgacaactg gccggttccc tagcgcgttt gcccaaaaat
    11341 cacctgccgc acgaccggac gacgcaaagg gagcggccgc gccgggccgt caccgcagga
    11401 gttttcccgg gccgtcctcg tagtacgcga cggcctcgtc cccggtgggc cagttgcgca
    11461 gcagcagggt ggcgacctcg ccgagcaccg catggtccgt ccgtgccgcc agcaggcgca
    11521 catcgacccc ggcgaaatcc ggcagcggct cggccgacgg cccggacggg gcggccgcag
    11581 cccgttcggt gcggggggta gtcgccacgc tgctctcctc tgaccggctg gacggtggtt
    11641 tcccggactc ccgtccacgg aaacacgcgg gggcggcgga cggccaggcg gccggcccgg
    11701 gggacggacg gccgggcccg gagccccgcc gcccggccgg cgtcgggcgc ggttccggtc
    11761 ccggccgtcc gggagtcagg cggtggactc cagggcgcgc atccgggcgc gggtgcgctg
    11821 cgcctcgggc ccggcgtcct cgccggcccg ctgccactgc tcccagctct cccggtaggc
    11881 gtgcagcgcg gagcgggggc cggcggtgac ctccaggacc ccggcgcggc ggtggtgggc
    11941 gcgggcggcc agcagggcgc tgccggcccg gccggcggcc gcggcggccc ggcggtagca
    12001 ggcggcggcc cggtcgtggc gctcccggga gtcgaagcgg cggtccagca gcagctgcac
    12061 gtcgcccact tcgagccagg cttcggcgca caccgcgtcc ggtacgtccg cgccgcgggc
    12121 ggccagctcc agcacccagt cagcctcgtg cagatcggcg agcgagggct ggcgttcgtg
    12181 gcgcagccgc agcgcccggc cgaagagcag ccggtggctg cccaggtcgg ggtcgtgcgg
    12241 cgcgacccgg gccagcgcct cgcgcaggac gtgcaccgcc tcgttggcga gccgcttggc
    12301 gggctccccc ggaggctcca gccgggcccg cagcagcagc gcggcgcccc gctcggcgag
    12361 cagggagctg tgctcgggcg agtcgggggc ggtcagccgc agcgcggcgg ccagcgcggc
    12421 gatcgcggcg tccagggcgc tcagcgcgcc ggtgcgggtg tggacggcgc ggtgggccgc
    12481 ggccgtccgg cgcaggctgt ccgcctccag gcccgggtcg tccagcgccc gggcgatctc
    12541 ccgggcgcgt tcgagggccg gcagcaccga cggcaggccg gcgccgccgt tcagctcccg
    12601 ggccgcggcc aggtcgagca gggtctcgca caccagccgg tcggcggcgc tgccgcggcg
    12661 gcgcagcagg acggtggcgg tgtcgaggtc gtcggcggcg cggacggcca gcgcctcggc
    12721 ggggcgcggg ccttcgggac gcgtccgggc ggcccggcgg gcctggtcga gcaggacgcc
    12781 gccgcgggcc gcgtagacct cgccgggcac ctgctcgccg ctgggccact ggtcgagcag
    12841 gtcggtgagg gaacgttcgg cctcgtcgag ggggtcggcg gggccgtcgg cgccggccgc
    12901 ggcgtcgtcc tcccccgcac cgggcgtcgc gccgggcgtc tcggacaggg cggccagccg
    12961 ccgcaggacc tcggtgcgca gcaccatgct ctccaggacg cggggatcga gcaggctcat
    13021 cagcccgcag gcggtgtgca gttgacgggc ggcgtcggtg agcgccgcgc gctcctccgc
    13081 cacggtgccg gcccggcgcc gttcgccggc ccgggcgtac gcgacccggc cgcgcacgat
    13141 cagcgcccgg gtgcgctcgg cgtccccggc ggtgtccccc gcggcgtcgt ccccgccggc
    13201 ggcgtcggtg gcggaccggg ccgcccgctc cgcctcctcc agggcgtccg gctggcccca
    13261 cttcgcccag gcgtgcagca gggcacgggc gaggtcggtg ccggccggcg gcaggcggtc
    13321 ggcggcggcg cgcagcaggc gcaccgcctc gatcaggtcg cggacggcgc ggtcctgttc
    13381 gtagcgctcc agcagggcgg cgccctcggc ggccgggccg tcggggacgt acggccgccg
    13441 gccggccggg cgcagcgccg gttcgaagcg gcgcaggacg cgttcggaga cccgggcgaa
    13501 gggtgcgggg acggcgctcc ccgggccacc gccggcaggg accccctggc cggcctccgg
    13561 ttcgcggccg ctgccggaga gcatggcgac cgcgacggcc gggaagttgc gggcgctgcg
    13621 gccgaaggtg cgctcgatgt agagcgagca gtgcttgagg atcagggccg cctcgcccgc
    13681 gctgagccgg ctgaggagtt cgtcccgtac ccctggcgcg aagtcgtacc aggggccggt
    13741 gccggtgctc tgcccgtcgg acggcctccc ccgggccccc ggggagcggg gaggtgcccc
    13801 cacgtccggc gggagttgcg tgaccaggcc gctgagcagc acctcggcga gttcggccgg
    13861 cccggtctgc ggcagcatcg cgcgctggac gagctggatg acgggcagcg cgagcggtac
    13921 ggccgagagg tgcaccgcga gcagccgcgc ggcgggggac gcctgctgct cgaacgcgcg
    13981 gaccatgcgc gacggttcgc cgcctccggg cgcgtcctgc gggccgggcg cgggctcggc
    14041 gccgtggtcg atccgtacga cgcaggccgc gccgcgcagc gacagcccgg cgtcggcggc
    14101 ggcgagccgg gcccaggagc cgagggccga gggggtggcc gacaggaccg ggacggcgcg
    14161 ctcgcggggc gggccgggcg gcgcggccgg cgccggggcg ggccggcggc ggcgccgggc
    14221 cgggaggaag tccagcgcct ggtagggccc ctgccggcgg acgagggtgc cggggaccgc
    14281 gggcagcagg gtgcgccccc acatgcgctg cggcagcggc tggacgacgg cgagcggggc
    14341 gtcggccgcc cagcggtaga gcagccgctg catccggccg tcgcgccaca gcgggcccgc
    14401 gcagtcgctg atgacgaggg tgaggtggtg gccggtgggg tcgtgcagct ggtcggcggg
    14461 gcgcagcggg ctgccggggc cgggcgccgc ggcgacgccg acgtcccggc cgtgcgggtg
    14521 gaggtagtgg acggtgacgt cccggaacgc gcccacccgt tcacagacct ggcgcaggtc
    14581 gtgcagcatc tgctcccaga cggccatcga ggacgagccg tccatcagca ggcgcagggc
    14641 ggcggcacgg cggtgcaccc cgcgcagcac cggtatgacc gtttcggcgt gcgcggagag
    14701 ttcggcggtg gcgggctcgt cgagggtgtg gcgggccggg gcggccggcg ggcggtagcg
    14761 ctggacgggg cgcagcgcgc gctgcagcgg cagcagtccg gggaaggcgg aggcgatcgg
    14821 cacggcgacc tcgccgaggc ggtggtggtc cgggtcggcg gcccgctcgt cctgggcggg
    14881 cagcaactcg gcgacgcggc gccgggcgcc gtcgcgcgac gaggggggcc gcccggcgga
    14941 ggcgtcgggc ccgctgccgg acgcgggcgg tacgccgtcg cgcgccgggt ccgccgcacc
    15001 ggccggcccg acccggaaag tggccggatc cgtacggtcg ggccggtccg tgcggtcggt
    15061 ggccgcgtcg gccgggcccc cgggcggtgc gtcgggagtg atccactggg cgagccagag
    15121 ggcgtcggcc atcgcgcggg cgtcgggcgg cagccccgcc gcggtcagcc gggcgaccag
    15181 ctcgtcgagg ggccctggac cgggcgcccc ggagggcatc gcagtcacct cgtccgatcg
    15241 agaggccgca tcagctccgc cgtcaggcgc cgtcgggtct cctcctcgtc ctggtcggtc
    15301 cagccggcct tctgggtgag gtggatggcg ttgaagagct ggtcgacggc gcggacgtcg
    15361 ccgggctcgc ggtccaggaa gcggtcgatc acggcttcgt agcgctcggc ggccccctcg
    15421 ccgaagtgcg cccgcaccat ggcggccagc cgctccttgt cgggggccgg gatgtggagg
    15481 tggatgcagc ggcgcaacag gggcgccggg aagtcccgtt cgccgttgct ggtcaggacg
    15541 atgaagggga aggcgcggca gcgcacccgg ccgtcgcgca ccgtcacccg cgccccgtcg
    15601 tcgctgagca cctgcacctc gggggcggat ccggccagtc gctccagctc cggaatcctg
    15661 aactcccctt cttccaggac gttgagcagg tcgttgggca ggtcgatgtc gctcttgtcg
    15721 agctcgtcga cgagcaggac gcggggccgt gcggcgggca gcagggcggt gcccagcggg
    15781 ccgagacgga tgtagcggcc gatgccgccg cccggctcgt ccgtggggtc ctcgccgtcc
    15841 gcggcgccgc tgtccgccgc ggacggtgcg gcgcgggcga tctggaggtc ctggaggcgg
    15901 ccgatggcgt cgtagtcgta caggccgtcg cggagcgtgc tgcggctgac gaccggccag
    15961 ccgagcaccc ggccgaggcc gagttcgtag gcgaccgaat gcgccagggt gctcttgccg
    16021 ctgcccgggg cgccggtcac cagcagcgga cggcgcagat agagcgcggc gttgaccagc
    16081 tcgcgctcgg tctcgcccgg acggtggtgg ctggcctcgc ggtgctgcac gccgaggcgg
    16141 cgctcggagg cggggtccag ggcggcgggc ggcgccacga gcgggccgcc gtcgaaatcg
    16201 cgccaggggg gcggcggtgg aaggtgctcg attccgtcgt gcggtgcgcc cgcgccacga
    16261 tagatgagcc agtcgctcac gtcggaactc ctcgtcgccg gcccggcatc ggtcaggaac
    16321 gggggccggg gagaaccgcc ggagacgtcg gcacccgccc ggccgtcccc cgcgtccgcc
    16381 accgacacac acgcaatcac gtcgtcacgt catcacgaac aagtcttcca cgacgctatg
    16441 acagtaccca tccatacgga agcgcacggg gcggtttccg gtctcgcgcc gcagcaccgc
    16501 ggggcgccaa gtgccgtgca cggggcgcgg tttgggcatg tgccgggccg tgcgccggtc
    16561 cggcgcggga cgagcggccg ggccgggagc gggcgccggg cgcatgcgcg gggcgcacgc
    16621 ggcgccccgg cagccgcacc cgtacgcggc gccccggcgg ccccgccgga cggccgtcgc
    16681 gcgctcatcc cggcgacacc tgggggcggt ccgggaacag ctgcggaatc gggtcctccg
    16741 gatcgtcgta gaggagcacc agatcgcggg cccagtgcgc gccctccccc gcggcctccg
    16801 ccgccttggc gcgcagctga cgcaccagct cgggcagccg gaccacaccg cccgagccct
    16861 ggagcagctc ccggatcccg cggtggaact cctcgcagga ggcgtcgcag gcccgctcct
    16921 ccccgtggcc gcgggccggc cacagcgcgg cggggaagcc ggtgtccagc gcggcgccga
    16981 ccgtgtcgcg gccgaacccg tcggcgaccg tgtggcacag cgcgggcagc gcgccctggt
    17041 ccgccgtctc cagcagccgc cagatcgcct cggtgcagcc cccgccgggg cgcgggccgg
    17101 cgcccgggtc cggcgggagg cgcagcgccc gcagcccggg ggcggcggcc aggccctgcc
    17161 agcggcgcag ccaggccgga tcgacctgcc cgcgccgccc ctggtcgcgc aggaccaccg
    17221 cgcgcccggg ccccaccggc cgccgccggg cggtgcgccg gggcgaggcg gcgacctccc
    17281 actggccgac ggcggtgtgc cagcggcctt cggggacggc gacctccagg cgtacccggg
    17341 cgcccgggcc cgcgtcaccg tcggcctgca gcagccgtcc gccgagccgt tgcagcacct
    17401 gctcccgcgc ctgctcgaag ggcaccccgc cggccgcttc ctgaacgtcc acccgcagcc
    17461 actggccccg gccgtagccc tcgctgaccg accagttgta gagctcgtgg ccgccctcgt
    17521 catagaagag cggctcgaac tcgacgagca ccgagcgcgg ccgccggcgc accggcccga
    17581 tccggcgacg gtcctgcggc tgcagcacca ccgccttggc ctggacgaac tccgcgagcc
    17641 tggccgcgtc ctcgcggacc gcggcggcct gctcgtccgg cgcgtcccgc accgcgtcgg
    17701 cgcagcgctg cgccacgatc cgcaagtagt gcacgaacgc gcgcagttcg gtgtacggat
    17761 cgctgccctg gtagagcgcg ccgtggccgt cccgccaggt ccgcagcgcc caggcaccgg
    17821 gcccgtcgcc gcgctccagt acttcgccga ccgccgcctc caccaccagc gggtcgcggg
    17881 gtgcgggcag ccgggcgagc aggtgcagcg cctgcagccg ctcctgcacg ccccacagcc
    17941 ggccgcgccc cgccatgatc gcgtgctggg cgtcgaacca ggtggggccg ccggcccggc
    18001 cgagctcctg cccggcccag tgccagcggt cgtgcaggcc cgtcagcgcg tggtacgggt
    18061 cggggccgag gtcctccgcg ccggacgcgc cctcgacgag gtgctcgggg cccaggccgc
    18121 gcagcgcggt gacgggcacc gcgagcccga cgtggtcctg ctggtggcgg cccttgacga
    18181 tgccgaccac ctcgccgcgg tcgcagtcga gcagcggccc gccggaggcg ccgggggcga
    18241 cccggacgtc gctgccgaac tgcagcccgc gggcgtcccg ggcgccgaac cggacggcga
    18301 tgaacgggtc gaccggggcg gcgggcggcg cggagcggtc ggcgccgcac ccggcaccgg
    18361 actcgcgtat gtcgcgttcg ccgggccggg acccgcccga ccgttcgtgt ccgcggaaga
    18421 tgtaggcgtc ctccaggagc gtcgccggct ggtcgctgag ccaggcgcag gggtgcgcgg
    18481 gcgcggggtc gagcagccgg accagggcga ggtcggcgcg ggcggcgggc ccggcctgcg
    18541 ggtcgggccg gctcaggtcg tacgcgagcc gcgcgggcgc cacacggccg ccgaacgcga
    18601 ccccgaacac cccgtccggg ccggtcgcgc ggcgccggcc gtcgctggcg gtgagcacat
    18661 gggcgcaggt cagcacccat cccggcgcga tcagcacgcc gctgccccac agcggggcgt
    18721 cgggcaccgg gggtgcggcg cgcagcgcga cggtggtgcg tccggcgagg tcgaggagct
    18781 gggcgtaccg ggcgcggtcg ccccggccgg cggccggtcc ttcgggggtg gccatcagcg
    18841 gcccgcgtcg tccggctccc ggatgccggg cggtggcacc cggtgctcct cgggtgcggg
    18901 cgccccgccg tcccggcgcc aggtgagcgt gaccgacaga ttggtcttgg cctcgccgtc
    18961 cgcgagcagg gccacggcct tgccgggctt ggccgacagc tccacgccga aggtcacgct
    19021 ggtctcgtcc ggcgcgaccc gtgcggcggc ctggcggacg ctgctcgcga ccccgccgat
    19081 cacctcgcgg agtccctcga cccgggcgcc gagcgcgtcc caggcgccca cgtcctcgaa
    19141 gtcgtccgtg ctcccgtcgg tcccggcgag gccggcggcg tcgagccggg agacccgggc
    19201 ccagacctcc gtaccgtcgg gcatttcgat gcgctgcgcg cgctcgtgca tcacggcctc
    19261 ctgctccccc tgaacggcaa ttcggccatt cccccattgc cgcagggccg ttgacaggtg
    19321 atcaggctag cccgcggccg ccggtggcgc gagaggtccg cgggcctgcc tatcctggcc
    19381 gggaatgtcc catgacccct ggtggagagc gcgtgtattt cactgaccgt ggcatcgagg
    19441 agctggagaa ccggcgcggc gaggaggagg tcaccctcgg ctgggtggcc gaacagctgc
    19501 ggacgttcgt cgatctgaac ccggacttcg aggtgccggt ggagcggctg gcgacctggc
    19561 tggcgcggct ggacgacgac gaggacgagt aaccgggcac cggccgcagc agccctccgg
    19621 gcgaccgaac accctggtca gcggcccttt cgtggggcgt acccctaggg ggtgtcgacc
    19681 cacgggaccg gggtcggctc cgggtcgggg ccgcttgact tccgcaatcc gcgatatatc
    19741 gtgttcattg agaacgcgat atgttgcgtt gcacggctat ccaggggagg ccaggaatgt
    19801 cagcccggac cgagtggtcg cagaatcccg tgcaggtgac cgagccacgc acactggaga
    19861 tcaccgagcc cgtcgacgcg ctcaacgtgc gcgtgtacgg cggcacggtc aatgtcgtcg
    19921 gcacctcgga ccgcggcccg gcccgcctgg agatcagcga gctgcacggg ccgccgttga
    19981 ccgtctcgtg cgacggcggc gtcctgacgg tcgcgtacga ggacctgccc tggcggggct
    20041 tcctgaagtt cctcgaccgc cggggctgga accgcagcgc ggtggtctcg gtgacggtgc
    20101 cggccggcac ccgcgtggag gtcggcgtgg tcggcgccac cgcggtggtc tccggcatct
    20161 ccggtgacac cgacgtccgc ggcgtcaccg gcgacagcac actggtcgga ctgaccggcg
    20221 cggtgcgcgc cgagacggtg tcgggcaacg tcgaggccca ggcactcacc ggcgacctgc
    20281 gcttcacctc cgtctccggc gacctgacgg tcatcgacgg cgcgggcggc ggggtgcacg
    20341 ccgactccgt cagcggcgac atggtcctcg acctggacct cacccacgcc gccgacatca
    20401 acctgacctc ggtctccggg gagatcgcca tccggttgcc cgacccggcg aacgcccggg
    20461 tggaggccga caccacgacc ggcacgatcg ccaacgcctt cgacgcgctg cgggtcagcg
    20521 gccagtgggg cgccaagaag atcaccggct cgctgggcgc gggcagcggc accctcaagg
    20581 ccaccaccgt ctccggcggc ctggccctgc tgcgccgccc cgcccgcgag gacggccgca
    20641 gcgggccgga cggccccggc gccggcccgc acgaggactc ccccaccgcc ccgcccgccg
    20701 ggaagaaggt gctctgagca tgccccccgt cttcgcccac ggccgtctgc gcctgtatct
    20761 cctcaagctg ctcgacgagg ccccgcggca cggctacgaa atcatccggc tcctggagga
    20821 gcgcttccag ggcctgtacg ccccctccgc cggcacggtc tacccgcggc tggccaagct
    20881 ggaggccgag gggctggtca cccacgcgac cgagggcggc cgcaaggtct actcgatcac
    20941 cgacgccggc cgggccgaac tcgccgaccg cggcggtgag ctggccgaac tggaactgga
    21001 gatcagggaa tcggtcgcct cgctcgcctc cgacatccgc gccgacgtca gcggctccgc
    21061 ccgcgacctg cgccgggaga tccgggaggc cgccaagcag gcccgcgagg gcaagcgggg
    21121 ctccgccggg gccgcgcgcg cgggcacgga gaagcaggcg gccggggacg cgggcggcgg
    21181 tcggccgttc ccggaagccg cggactacct cgatgccgcc ttcggcgaca aggacgcctg
    21241 gcggcaggcg aaggaggagt tccggcgcgc caaggacgag tggaaggaac aggcgcggcg
    21301 ggccaaggag gagagcaagc gggcccggca ggacgcccag cgggcccgta agcaggccag
    21361 ggacgcccag gtgtccgcgc gcgaggaggt ccagcgggtc atccaccgcg tccaggaaca
    21421 ggcccagggg gcggtgcgga ccggcgactg gtcgggcgcg gtgcgcgagg cgctggcgga
    21481 ggtgtcccgc gaggtcggca ggttcaccgg cgaccgtccc ggcgagggcc gggccgcgga
    21541 gggcgccgag ggcggcaacg ggacggcccg ggtgaccgtc gagcgcgtcg ccccggcggc
    21601 ggagacgc
//
