LOCUS       NZ_CP017157            21059 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces lydicus strain 103 chromosome, complete genome.
ACCESSION   NZ_CP017157
VERSION     NZ_CP017157.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lydicus
  ORGANISM  Streptomyces lydicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Complete genome sequencing of Streptomyces lydicus 103 and metabolic
            pathways analysis of antibiotic biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2016) Key Laboratory of Systems Bioengineering
            (Ministry of Education), Tianjin University, Tianjin 300072, PR
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001729485.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:23:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,288
            CDSs (total)                      :: 7,195
            Genes (coding)                    :: 7,061
            CDSs (with protein)               :: 7,061
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 47 of 134
            Pseudo Genes (incomplete)         :: 104 of 134
            Pseudo Genes (internal stop)      :: 11 of 134
            Pseudo Genes (multiple problems)  :: 26 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:52:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5579688
            Orig. end                         :: 5600747
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017157.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA is available from Prof. Ying-Jin Yuan.
            Annotation modified by submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21059
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="24"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21059
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21059
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11059](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11059
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(58..73)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.33"
                     /tool="antismash"
     misc_feature    794..809
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            complement(942..1799)
                     /locus_tag="SL103_RS24295"
                     /old_locus_tag="SL103_24295"
     CDS             complement(942..1799)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-267). E-value:
                     2.2e-27. Score: 88.2. Matches aSDomain:
                     nrpspksdomains_SL103_RS24295_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572374.1"
                     /locus_tag="SL103_RS24295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24295"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_069571066.1"
                     /sec_met_domain="PF00561 (E-value: 4.3e-21, bitscore: 74.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.6e-13, bitscore:
                     49.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTFTAPDGTALAYHLVGEGEPLLCLPGGPMRASDYLGDLGGLSR
                     HRRLVRLDLRGTGDSGVPADPATYRCDRQVADVEALCEHLGLPRVDLLAHSAAGDLALL
                     YAARHPHRVRSLTLVTPRARALGVDFTVEHRREAADLRAAEPWFPGARAAFDAVWTGSA
                     TDAEWDAATPFFYGRWDAAARAHAADEVARTNEPAAERYAAAGAFDPAAARAALAWLAA
                     PVLVLAGAWDGGPLPRVAATVAEAFPRGELTVLPDTGHYPWLDDPAAFSATVAAFLGAA
                     ATES"
     aSDomain        complement(999..1736)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS24295_Abhydrolase_1.1"
                     /evalue="2.20E-27"
                     /label="SL103_RS24295_Abhydrolase_1.1"
                     /locus_tag="SL103_RS24295"
                     /protein_end="267"
                     /protein_start="21"
                     /score="88.2"
                     /tool="antismash"
                     /translation="PLLCLPGGPMRASDYLGDLGGLSRHRRLVRLDLRGTGDSGVPADP
                     ATYRCDRQVADVEALCEHLGLPRVDLLAHSAAGDLALLYAARHPHRVRSLTLVTPRARA
                     LGVDFTVEHRREAADLRAAEPWFPGARAAFDAVWTGSATDAEWDAATPFFYGRWDAAAR
                     AHAADEVARTNEPAAERYAAAGAFDPAAARAALAWLAAPVLVLAGAWDGGPLPRVAATV
                     AEAFPRGELTVLPDTGHYPWLDDP"
     misc_feature    1782..1798
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.34"
                     /tool="antismash"
     gene            complement(1897..4416)
                     /locus_tag="SL103_RS24300"
                     /old_locus_tag="SL103_24300"
     CDS             complement(1897..4416)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602143.1"
                     /locus_tag="SL103_RS24300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24300"
                     /product="MFS transporter"
                     /protein_id="WP_069571067.1"
                     /transl_table=11
                     /translation="MGGTTLSARAGRTGPPAPGATPAPAAAATRATGPGGGAPVALGPR
                     RFRAVFLGLMLTLLLAALDQTVVATALPKIVGELHGLGSMSWAVTSYLLASTIGLPLYG
                     KLGDLFGRKPVFLFAIVVFTAGSALAGWSRTMHELVLFRAVQGAGGGGLMIGVQAIIAD
                     VVPPRARGRYLGLIGAAFGIASVAGPLIGGFCTDHVSWRWCFYLNVPFGALTLLLIAFV
                     LKLPRPAGRPKLDIAGALLLAAFSTCLVLLTSWGGTEYAWNSRVILGLGAGALGTALLF
                     LAVEYFAAEPLIPLRLFRDSVFNITGLIGAAVGLALFGAASYLPTFLQMVDGASATASG
                     LLMLPMMGGIVLASVVSGLLISRTGRYKVFPLLGCAAAAVGMWLLTRLQQDTPREVYSL
                     WMGVLGLGLGCVLPVLVLAVQNSVRRSDLGTATSANNYFRQIGGSVGAALFGTLLADRL
                     ARRLDDRLPASTRLPDPESITPQLVRALPASLRDSYVAAYAHAMPGIFFYFVPVLVLGF
                     VLALFLKEKPLVSHTSHAPQAAPTPHPPYGDGADTAAVPQARPAADQSPVNSRGPAGSY
                     RKGHAYAAAGHSGVPVCGTVQHHDGSIVPRAALTLIDVAGRQIGRGATGEDGRYALSTP
                     GTGSYVLIAAAGGHQPQAVSVTVGERPVELDVVLGGAGRLAGTVTTGDGTPVRDAMVTL
                     TDVRGEVVATTRSGREGGYVIGELVAGEYTLASSAPAFRPAALPVTVQASRETRQDIEL
                     AGGAVLRGTVRAGGGRPVEDARVTLLDAAGNVVDTATTGPDGLFRFVDLSAGEYTVIAA
                     GYPPVATVLQVAGGGRTERDLQLGHED"
     gene            complement(4669..5112)
                     /locus_tag="SL103_RS24305"
                     /old_locus_tag="SL103_24305"
     CDS             complement(4669..5112)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (3-146). E-value:
                     1.4e-23. Score: 75.8. Matches aSDomain:
                     nrpspksdomains_SL103_RS24305_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038765.1"
                     /locus_tag="SL103_RS24305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24305"
                     /product="SRPBCC family protein"
                     /protein_id="WP_069571068.1"
                     /transl_table=11
                     /translation="MGQVEATTQREIAADPEDVFDALADYAGTRRQLLPEHFSEYEVRE
                     GGDGKGTLVHWKLQATSKRVRDCLLEVDEPTEGQLVEKDRNSSMVTTWVVTPAGEKRAK
                     VVVTTTWQGAGGVGGFFERTFAPKGLGRIYDALLAKLAAHMEK"
     aSDomain        complement(4675..5103)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS24305_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.40E-23"
                     /label="SL103_RS24305_Polyketide_cyc2.1"
                     /locus_tag="SL103_RS24305"
                     /protein_end="146"
                     /protein_start="3"
                     /score="75.8"
                     /tool="antismash"
                     /translation="VEATTQREIAADPEDVFDALADYAGTRRQLLPEHFSEYEVREGGD
                     GKGTLVHWKLQATSKRVRDCLLEVDEPTEGQLVEKDRNSSMVTTWVVTPAGEKRAKVVV
                     TTTWQGAGGVGGFFERTFAPKGLGRIYDALLAKLAAHME"
     misc_feature    complement(5212..5225)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.97"
                     /tool="antismash"
     misc_feature    complement(5219..5235)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 21.83"
                     /tool="antismash"
     gene            5269..6297
                     /locus_tag="SL103_RS24310"
                     /old_locus_tag="SL103_24310"
     CDS             5269..6297
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602145.1"
                     /locus_tag="SL103_RS24310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24310"
                     /product="Rv2578c family radical SAM protein"
                     /protein_id="WP_069571069.1"
                     /transl_table=11
                     /translation="MRWENLGESPSALFGTDVVSRTIDTPEFRGITFHEVRARSIVNRV
                     PGASRMPFEWTVNPYRGCSHACVYCFARKTHSYLDLDTGLGFDSQIVVKVNAPELLRRE
                     LAGRRWRGEHIAMGTNVDCYQRAEGRYRLMPGILAALRDHANPFSILTKGTLILRDLEL
                     LRQSAAVTDIGISVSVGFLDRELWRTVEPGTPAPDRRLDVVRTLTAHGIPCGVLMAPVI
                     PFLGDTPEQLRATVRAVAEAGAGSVTPLVLHLRPGAREWFMAWLGHHHPQLVRRYETMY
                     ADGAYAPKWYQRRITRQVHELATEYGIGPTRPGAARRIPPPPVPAADPAGTAAEPTQLT
                     LL"
     gene            complement(6329..6685)
                     /locus_tag="SL103_RS24315"
                     /old_locus_tag="SL103_24315"
     CDS             complement(6329..6685)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090474.1"
                     /locus_tag="SL103_RS24315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24315"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_069571070.1"
                     /transl_table=11
                     /translation="MRIGELARITGASPRALRHYEREGLIASERGANGYRVYDARTAVR
                     VRNIRHLLTAGLTLADVRCFAVCLDGDLTTAPPSAEGLRIARERLAAIDERIAAQTEAR
                     DRLARALDAVVPAG"
     gene            complement(6752..7561)
                     /locus_tag="SL103_RS24320"
                     /old_locus_tag="SL103_24320"
     CDS             complement(6752..7561)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (19-183). E-value: 2.4e-13.
                     Score: 42.4. Matches aSDomain:
                     nrpspksdomains_SL103_RS24320_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018545214.1"
                     /locus_tag="SL103_RS24320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24320"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_069571071.1"
                     /sec_met_domain="adh_short (E-value: 7.1e-32, bitscore:
                     109.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 7.3e-29, bitscore:
                     100.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERTTQTGPDMPGTGSDRRVVLVTGAGTGIGRATALAFAAEGARV
                     VAVGRRAEPLAGAADAAAATDGSGGGGITPCVADITADGAPEAVVRHAVERYGRLDVLV
                     NNAAVVGDGALGSYTREGMAPLLATNLVAPVLLTQEALPHLERTGGVVVNVSTSVGQRG
                     WPGNAVYAATKTALELLTRSWAVELAPRGVRVVAVAPGAIETPIALHQGWSAEQRAAVR
                     KWQIAHTPMGRVGRPEEVAWAVTRLAAPAASFVTGVVLPVDGGAVVG"
     CDS_motif       complement(6971..7024)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SL103_RS24320_0002"
                     /evalue="2.90E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="SL103_RS24320"
                     /protein_end="197"
                     /protein_start="179"
                     /score="0.7"
                     /tool="antismash"
                     /translation="LTRSWAVELAPRGVRVVA"
     aSDomain        complement(7013..7504)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS24320_PKS_KR.1"
                     /evalue="2.40E-13"
                     /label="SL103_RS24320_PKS_KR.1"
                     /locus_tag="SL103_RS24320"
                     /protein_end="183"
                     /protein_start="19"
                     /score="42.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLVTGAGTGIGRATALAFAAEGARVVAVGRRAEPLAGAADAAAA
                     TDGSGGGGITPCVADITADGAPEAVVRHAVERYGRLDVLVNNAAVVGDGALGSYTREGM
                     APLLATNLVAPVLLTQEALPHLERTGGVVVNVSTSVGQRGWPGNAVYAATKTALELLTR
                     S"
     CDS_motif       complement(7409..7504)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SL103_RS24320_0001"
                     /evalue="3.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="SL103_RS24320"
                     /protein_end="51"
                     /protein_start="19"
                     /score="16.3"
                     /tool="antismash"
                     /translation="VVLVTGAGTGIGRATALAFAAEGARVVAVGRR"
     misc_feature    complement(7588..7600)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            7755..8294
                     /locus_tag="SL103_RS24325"
                     /old_locus_tag="SL103_24325"
     CDS             7755..8294
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602146.1"
                     /locus_tag="SL103_RS24325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24325"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_069571072.1"
                     /transl_table=11
                     /translation="MTEADVDGVSAVRVRGWQAAYRGLMPQAYLDAMSVTADAERRRSW
                     FARRSPEVADLVAEAAGEVIGWASVGPARDPDIAPGAEELPAPRPTAGELFALYVTPRL
                     IGTGVGRALLAAATDHAGTKGFRALYLWVVRGNTRARRFYERAGFEPDGVEETYEVGGR
                     SVPELRYRRPLTAGTP"
     misc_feature    8381..8401
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.93"
                     /tool="antismash"
     gene            8539..9981
                     /locus_tag="SL103_RS24330"
                     /old_locus_tag="SL103_24330"
     CDS             8539..9981
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576907.1"
                     /locus_tag="SL103_RS24330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24330"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_069571073.1"
                     /transl_table=11
                     /translation="MSVPDSVTGSATDEPALEPSADGAPTSLGTQAARQLATTTKSEPQ
                     MQAITSRWLLKSLPWVDVKGGTYRVNRRLQLRVGRGRVEFEQNGADDIRVIPRTLTELP
                     ALRGYDDGEVLKEIAGRFRVREVRAGQVLFEAGEPATEAYLVVHGRFARYTAGKYGEEE
                     VIGVVTDGDQMGDEALGRPAPLWQSSVRAETAGVLMVLPWDVLREFTDRVPSLAAHLTA
                     YAERQQRPVNRKGEAEVPVRAGHVGEPTLSGGFVDYDLAPREYELSLTQTVLRVHSRVA
                     DLYNEPMDQTQQQLRLTVEEIRERQEWELVNNREFGLLHNADYGQRISTYSGPPTPDDM
                     DELLSMRRKTRLFLAHPKAIAAFFRQCNKRGLVPGTANVDGHEVPAWRGVPIFPCGKIP
                     ISETHTSSIIALRTGEADQGVVGLYQTGLPEEFQPGLNVRFMGIDQAAVIKYLVTAYYS
                     LAILVPDAAGVLENVQIGRNAD"
     gene            10001..11059
                     /locus_tag="SL103_RS24335"
                     /old_locus_tag="SL103_24335"
     CDS             10001..11059
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093087.1"
                     /locus_tag="SL103_RS24335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24335"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_069571074.1"
                     /sec_met_domain="T1TS (E-value: 6.4e-53, bitscore: 179.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPPHTTAGFTLPGPPRIAPAPRNRRGGAVPGLRYRPAAPADPE
                     KVREIDRRLETWARELDLFPSEWSGDFAEFQFGRAVVLQHPGAADLERLTAAGKLLLAE
                     NIVDNCYCEEDEGRGGAHRGLGGRLILAQSALDPYHGTPEHEAEWRRGVQADGPLRSYH
                     VALKDYAALATPSQTDRFVHDIARLHLGYLAEAAWAETRHAPKVWEYLVMRQFNNFRPC
                     LSIVDAIDGYELPEALYARPEIQRVTALACNATTIVNDLYSFTRELASDPHHLNLPQVV
                     AANDQRGLKAAYLKSVEIHNQIMEAFETESALLAATSPLVERYLQGLADWVSGNHEWHA
                     TNTDRYQLPNYW"
     gene            11092..11967
                     /locus_tag="SL103_RS24340"
                     /old_locus_tag="SL103_24340"
     CDS             11092..11967
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574303.1"
                     /locus_tag="SL103_RS24340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24340"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_069571075.1"
                     /transl_table=11
                     /translation="MTIAHADTARTPVPTQSTYQSRVADYWNAEENPVNLELGKIDDLY
                     HHHYGIGDADRSVLDEPDPDRRRERVTAELHRLEHAQAELLASHLGDVSPADRVFDAGC
                     GRGGGSVVAHQRYGCHTDGATISAKQADFANEQARKRGIDDKVRYHHRNMLDTGFTAGA
                     YAASWNNESSMYVELDLLFAEHARLLRRGGRYVVITGCYNDAYGRASREVSLINAHYIC
                     DIHPRSAYFRAMARNRLVPVHVEDLTAAALPYWELRREADHLVTGIEDTFLNAYRNGSF
                     QYLLIAADRV"
     gene            complement(12019..12669)
                     /locus_tag="SL103_RS24345"
                     /old_locus_tag="SL103_24345"
     CDS             complement(12019..12669)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981805.1"
                     /locus_tag="SL103_RS24345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24345"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_069571076.1"
                     /transl_table=11
                     /translation="MEDEFHELTDRVRAELRSPQDLVAYERLLGLARKNTPAGREELAR
                     MLVAVERPLWAREIAAFILGCAGDKRAFETLVLLLNYRDPVRCATAAHALSRLGDPRTA
                     RAAAALATNPLRTAYALHPVRLLAELRAPQSVPALIATLERLLTPHNPYWRVALACVEG
                     LGALGDRRAVPALTAAVAHPRLAAAAAASLARLGVHEVPEQRGSGTTPAERET"
     misc_feature    complement(12586..12588)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12653..12667
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    12756..12773
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.03"
                     /tool="antismash"
     gene            13060..14880
                     /locus_tag="SL103_RS24350"
                     /old_locus_tag="SL103_24350"
     CDS             13060..14880
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602148.1"
                     /locus_tag="SL103_RS24350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24350"
                     /product="3-hydroxybutyryl-CoA dehydrogenase"
                     /protein_id="WP_069571077.1"
                     /transl_table=11
                     /translation="MGPHSTPDLPTEAAPLSLATVAVVGLGTMGTGLAEVLTRAGREVI
                     GIDTDEAAARRAVAALEAATARAVRRERITERERQDALARFRTFTDLQAAADADLVIEV
                     VPEDYDLKRRVFAELDAVVRPDAILATGTNALSVTRLAADSQRPERVLGVHFFNPAPAM
                     KLVEVVSSVLTAPTAVAAVTQLARDLGKDPIAVGDRPGFVADGLLFGYLNQAAAMYESK
                     YATREDIDAAMRLGCGLPMGPLALLDLIGVDTARTVLEAMYAESQDRLHAPAPILGQLA
                     EAGLTGRKAGRGFYTYEAPGSGTVVPDAESPAPADALGTGRTVAAVGVAGSGTMASGIA
                     EVFAKAGFKVVLAARSAEKAEQAKARIAKSLGRSVDKGRMTAEARDAALDAITPAGSLD
                     AFGDVDLAVEAVAEDLAVKQELFRTLDKVCKPGAVLATTTSSLPVVACARATSRPQDVI
                     GMHFFNPAPAMKLVEVVRTVLTADDVHATVRAVCTKVRKHPVDCGDRAGFIVNALLFPY
                     LNNAIKMVEQHYATLDDIDAAMKLGGGYPMGPFELLDVVGLDVSLAIEKVLHAEFRDPG
                     LAPAPLLEHLVAAGCLGRKTGRGFREYARR"
     gene            15017..15820
                     /locus_tag="SL103_RS24355"
                     /old_locus_tag="SL103_24355"
     CDS             15017..15820
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602149.1"
                     /locus_tag="SL103_RS24355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24355"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_208869942.1"
                     /transl_table=11
                     /translation="MSQPARTQPSDTPDATSPGTRRAAAQRLKMRRELSAAAMELFATK
                     GYEATTVDEIAAAAGVARRTFFRHFRSKEEAIFPDHDDTLVRAEAVLDAAPPHENPLDT
                     VCRGIKEVMRMYAASPAVSVARYRLTREVPTLREAEIASVARYERLFTRYLLGHFDEGA
                     HREGDDDPLLAEVAASAVVTAHNHVLRRWLRAGAEGDVEAQLDHAFEIVRETFGAGIGA
                     GRTTTGEQPPAAVSREGEVLVAVARTDAPLEEVMRTIRKAIKERK"
     gene            16342..17679
                     /gene="ccrA"
                     /locus_tag="SL103_RS24360"
                     /old_locus_tag="SL103_24360"
     CDS             16342..17679
                     /EC_number="1.3.1.85"
                     /GO_function="GO:0043880 - crotonyl-CoA reductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (52-413). E-value: 5.2e-28.
                     Score: 90.0. Matches aSDomain:
                     nrpspksdomains_SL103_RS24360_PKS_ER.1"
                     /codon_start=1
                     /gene="ccrA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890465.1"
                     /locus_tag="SL103_RS24360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24360"
                     /product="crotonyl-CoA carboxylase/reductase"
                     /protein_id="WP_069571079.1"
                     /sec_met_domain="ADH_N (E-value: 8.7e-06, bitscore: 24.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-30, bitscore:
                     104.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKILDAILSPDATGADFAALPLPESYRAVTVHKDEAEMFAGLPT
                     KDKDPRKSLHVEDVPVPELGPGEALVAVMASSVNYNSVWTSIFEPLSTFGFLERYGKLS
                     PLTKRHDLPYHVIGSDLAGVVLRTGPGVNAWGPGDEVVAHCLSVELESSDGHNDTMLDP
                     EQRIWGFETNFGGLAEIALVKSNQLMPKPKHLSWEEAAAPGLVNSTAYRQLVSRNGAGM
                     KQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSEQKADICRAMGAEAIIDRSAEGY
                     KFWKDEQTQDPKEWKRFGKRIREFTGGEDIDIVFEHPGRETFGASVYVTRKGGTITTCA
                     STSGYMHEYDNRYLWMSLKRIIGSHFANYREAWEANRLIAKGKIHPTLSKTYSLDETGQ
                     AAYDVHRNLHQGKVGVLALAPEEGMGVRDEEMRAKHLDAINRFRNV"
     aSDomain        16498..17580
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS24360_PKS_ER.1"
                     /evalue="5.20E-28"
                     /label="SL103_RS24360_PKS_ER.1"
                     /locus_tag="SL103_RS24360"
                     /protein_end="413"
                     /protein_start="52"
                     /score="90.0"
                     /tool="antismash"
                     /translation="SLHVEDVPVPELGPGEALVAVMASSVNYNSVWTSIFEPLSTFGFL
                     ERYGKLSPLTKRHDLPYHVIGSDLAGVVLRTGPGVNAWGPGDEVVAHCLSVELESSDGH
                     NDTMLDPEQRIWGFETNFGGLAEIALVKSNQLMPKPKHLSWEEAAAPGLVNSTAYRQLV
                     SRNGAGMKQGDNVLIWGASGGLGSYATQFALAGGANPICVVSSEQKADICRAMGAEAII
                     DRSAEGYKFWKDEQTQDPKEWKRFGKRIREFTGGEDIDIVFEHPGRETFGASVYVTRKG
                     GTITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAWEANRLIAKGKIHPTLSKTY
                     SLDETGQAAYDVHRNLHQGKV"
     CDS_motif       17014..17076
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SL103_RS24360_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="SL103_RS24360"
                     /protein_end="245"
                     /protein_start="224"
                     /score="11.1"
                     /tool="antismash"
                     /translation="GDNVLIWGASGGLGSYATQFA"
     gene            17721..19733
                     /locus_tag="SL103_RS24365"
                     /old_locus_tag="SL103_24365"
     CDS             17721..19733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049399.1"
                     /locus_tag="SL103_RS24365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24365"
                     /product="protein meaA"
                     /protein_id="WP_069571080.1"
                     /transl_table=11
                     /translation="MTERQKDRPWLMRTYAGHSTAEASNELYRRNLAKGQTGLSVAFDL
                     PTQTGYDPDHILARGEVGRVGVPVSHLGDMRRLFQDIPLDQMNTSMTINATAMWLLALY
                     EVVAEEQGADISKLSGTTQNDIVKEYLSRGTHVFPPGPSLRLTTDMITYTVAHIPKWNP
                     INICSYHLQEAGATPVQEIAYAMSTAIAVLDAVRDSGQVPPEKFGDVVARISFFVNAGV
                     RFVEEMCKMRAFGRIWDKITRERYGIRNEKQRRFRYGVQVNSLGLTEAQPENNVQRIVL
                     EMLAVTLSKDARARAVQLPAWNEALGLPRPWDQQWSLRIQQVLAHESDLLEYEDIFAGS
                     HVIEAKVDALVTDCLAEIERIQEMGGAMAAVESGYLKSQLVSAHAERRARIEAGEEKIV
                     GVNCFEGTEPNPLTADLDTAIMTVDPANEARVVQGLHDWRDNRDETRAQEALSVLKKTA
                     AGDANLFAATLECARAGVTTGEWAWALRDVFGEFRAPTGVSSAPLAVAAEAGSPLAAVR
                     EKVAKTAAELGTGKLRLLVGKPGLDGHSNGAEQIAVRARDAGFEVIYQGIRLTPEQIVS
                     AAVAEDVHCVGLSILSGSHAELVPDVLDRLRRTGVDDVPVIVGGIIPSADATALREAGV
                     AAVFTPKDFGITEIIGRIVDEIRKANQLDPLEVPA"
     gene            19730..20695
                     /locus_tag="SL103_RS24370"
                     /old_locus_tag="SL103_24370"
     CDS             19730..20695
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519857.1"
                     /locus_tag="SL103_RS24370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_24370"
                     /product="CoA ester lyase"
                     /protein_id="WP_069571081.1"
                     /transl_table=11
                     /translation="MTAPVTRLRPRRSCLAVPGSNPRFLEKAQGLPADQVFLDLEDACA
                     PLAKEGARHSVVEALNGGDWTGKTRVVRVNDWTTHWTYRDVITVVEGAGPNLDCLMLPK
                     VQDAQQIVALDLLLTQIEKTMGFEVGRIGIEAQIENAKGLVNVDEIAGASPRLETIIFG
                     PADFMASINMKSLVVGEQPPGYGADAYHYILMRILMAARANDLQAIDGPYLQIKNIDGY
                     REVAGRAAALGFDGKWVLHPGQVEAANEVFSPSQEDYDHAELILDAYEWHTSEAGGKKG
                     SAMLGDEMIDEASRKMALVVAGKGRAAGMIRTSKFEAPEA"
ORIGIN
        1 cccttggctt cgaccgggtc gtgcgcgact tcctcgccct ccacccggac ggcacggtga
       61 tcgccctcgg cgaggggctg gagacccagt tctggcgggt ggacaacggc agcgtccgat
      121 gggtcagcgt cgatctggcc ggcccgctgg cgctgcgcga gcgcgtcctg ccgcacgggc
      181 cccggcagcg gctcatcgcc tgcgacgtcc gcgccaccac gtggctggcg cacgtcgacg
      241 cctcccgcgg ggtgctggtg accgcgcagg gcctgctgat gtacctccag cgggcccagg
      301 ccatcgggct gctcgccgcc tgcgccgggg cgttccccgg cggcacgatg gtgttcgaca
      361 ccgtctcccg acgtttcagc gcccgcaccc gcgccggcgc gaagggaccg ggcggccatc
      421 gtctgcccgc catgtcctgg ggcatggacg catccgagcg ccaccagctg cacaccgtcc
      481 accccgccgt cacggaggtg accgacgtcc ccctgcctgc cggccgcggc ctggtcggct
      541 acctcgcgcc gcgcgccggg accctgccgc tgctccgcgg cgaccgcccg ctcatcaccc
      601 ggctccgttt cggcgccgac ccacgccccg gagaaactcc gccacccgcc cggcgatccg
      661 ctccggacac gcaccactga tcgcatgtga cacctccggc cacacctcga ccgcggcccg
      721 gcgtacgcgc cgggccgcgg cccgctcggc gccgtgcacg ctgccccggc cggcgagcgg
      781 tgcgaggacc gggacgccga tggcgcgcaa ctcgtgcgcg cagggcagcg ccgggggcat
      841 cccggtgagg ggccccacca cggcaccacc ccctcaccag ggccgccccg tccgcgttcc
      901 gattccccta acttcgttac gaaccagggc agttcgaccc ttcagctctc cgttgccgcc
      961 gcgccgagga aggccgccac ggtcgcggag aaggcggcgg ggtcgtcgag ccacgggtag
     1021 tggccggtgt ccggcaggac ggtcagttcg ccgcgtggga acgcctcggc cacggtggcg
     1081 gcgacacggg gcagcgggcc gccgtcccat gcgccggcca ggaccaggac cggggccgcc
     1141 agccaggcga gggcggcgcg ggcggccgcc gggtcgaagg cgccggccgc ggcgtagcgc
     1201 tccgcggccg gctcgttggt ccgggccacc tcgtcggcgg cgtgcgcccg ggcggcggcg
     1261 tcccaacggc cgtagaagaa gggcgtcgcg gcgtcccatt cggcgtcggt cgcggaaccg
     1321 gtccagacgg cgtcgaaggc ggcacgggcg ccggggaacc acggttcggc cgcgcgcagg
     1381 tcggccgcct cccggcggtg ctcgacggtg aagtccacgc ccagggcgcg ggcacgcggg
     1441 gtgaccaggg tgagggagcg gacacggtgc gggtgacggg ccgcgtacag cagggcgaga
     1501 tcgccggcgg cggagtgcgc gaggaggtcg acgcggggca gcccgaggtg ctcgcacagc
     1561 gcctcgacgt cggcgacctg ccggtcacag cggtaggtcg ccgggtcggc ggggacgccg
     1621 gagtcgccgg tgccgcgcag gtcgagccgc accagccggc ggtgccgcga caggccgccc
     1681 agatcgccga ggtagtcgga ggcgcgcatg gggccaccgg ggagacagag cagcggctcg
     1741 ccctccccca cgaggtggta ggcgagggcg gtgccgtcgg gtgcggtgaa ggtgggcatg
     1801 gcgccatgtt cggcaccgca cgatgatctt ggcaagggat atagggcgcg gcggccgggg
     1861 cgagcgcctc cgtccgccgc gccgggaggc ggacgctcag tcctcgtggc cgagttgcag
     1921 gtcccgttcg gtgcggccgc cgccggccac ctggaggacg gtggccaccg gcgggtatcc
     1981 ggcggcgatc acggtgtact caccggccga caggtccacg aagcggaaca ggccgtcggg
     2041 gccggtggtg gcggtgtcga cgacgttgcc ggcggcgtcc aggagggtga cccgggcgtc
     2101 ctctaccgga cgcccgccgc cggcccggac cgtcccgcgc agcaccgccc cgccggcgag
     2161 ttcgatgtcc tggcgggtct cccgggacgc ctggacggtg accggcaggg cggccgggcg
     2221 gaacgccggg gcgctggagg cgagggtgta ctcgccggcc accaactcgc cgatcacata
     2281 gccgccctcg cggccgctgc gggtggtcgc gacgacctcg ccgcggacgt cggtgagggt
     2341 gaccatggcg tcgcggacgg gggtgccgtc gccggtggtg acggtgcccg cgaggcgccc
     2401 ggcgccgccg agcaccacgt ccagctcgac cgggcgctcg ccgacggtga cgctgaccgc
     2461 ctgcggctgg tgcccgccgg ccgccgcgat gagcacgtac gagccggtgc ccggcgtgct
     2521 cagcgcgtac cgcccgtcct cgccggtggc gccgcggccg atctgccgcc cggcgacgtc
     2581 gatcagggtg agtgcggcgc gcggcacgat ggagccgtcg tggtgctgga cggtgccgca
     2641 gacggggacg ccggagtggc cggccgccgc gtaggcgtgg cccttgcggt aactgccggc
     2701 ggggccacgg gagttgaccg gcgactggtc ggcggcggga cgggcctgcg gcacggcggc
     2761 ggtgtcggcc ccgtcgccgt acggcgggtg cggggtcggg gcggcctgcg gggcatgaga
     2821 ggtgtgggac accagcggtt tctctttcag gaagagggcg agcacgaagc ccaggacgag
     2881 caccggcacg aagtagaaga agatccccgg catggcgtgc gcgtaggcgg cgacatagct
     2941 gtcgcgcagc gaggcgggca gcgcgcgcac cagttgcggg gtgatcgact ccggatcggg
     3001 cagccgcgtc gacgccggaa gccggtcgtc gaggcggcgg gccagccggt cggcgaggag
     3061 ggtgccgaag agggccgcgc cgacgctgcc gccgatctgc cggaagtagt tgttggcgct
     3121 ggtcgcggtc cccaggtcgg agcggcgtac ggagttctgc acggcgagca ccagcaccgg
     3181 cagcacgcag ccgagaccga ggccgaggac gcccatccag aggctgtaca cctcgcgcgg
     3241 ggtgtcctgc tggagtcgcg tcagcagcca catccccacc gcggccgccg cgcagcccag
     3301 gagggggaag accttgtagc ggccggtgcg gctgatcagc aggccggaga cgacggacgc
     3361 cagcacgatg ccgcccatca tgggcagcat cagcagcccg gaggcggtgg cggaggcgcc
     3421 gtcgaccatc tgcaggaagg tcggcaggta gctcgccgcg ccgaagagcg cgaggccgac
     3481 ggcggcgccg atcaggccgg tgatgttgaa gaccgagtcg cggaacagcc gcagcgggat
     3541 gagcggttcg gccgcgaagt actcgacggc caggaacagc agggcggtgc cgagcgctcc
     3601 ggcaccgagg ccgaggatga cgcgcgagtt ccaggcgtac tcggtgccgc cccaactggt
     3661 cagcagcacc aggcaggtgg agaaggcggc gagcagcagc gcgccggcga tgtccagctt
     3721 ggggcggccg gcgggccggg gcagcttgag gacgaaggcg atgagcagca gcgtcagcgc
     3781 gccgaacggg acgttcaggt agaagcacca gcgccaggag acgtggtcgg tgcagaatcc
     3841 gccgatcagc ggcccggcca cggaggcgat gccgaaggcc gcgccgatca gccccaggta
     3901 gcggccgcgg gcccggggcg gcacgacgtc ggcgatgatc gcctgcacgc cgatcatgag
     3961 cccgccgccg ccggcgccct ggacggcccg gaagagcacc agttcgtgca tcgtgcggga
     4021 ccagccggcc agcgccgagc cggcggtgaa gacgacgatg gcgaagagga agacgggctt
     4081 gcggccgaag aggtcgccga gcttgccgta cagcggcagg ccgatggtcg aggcaaggag
     4141 gtaggaggtc accgcccacg acatcgagcc caggccgtgc agctcgccga cgatcttcgg
     4201 gagcgcggtg gcgacgaccg tctggtcgag ggccgcgagc agcagcgtca gcatcagccc
     4261 gaggaagacc gcgcggaagc ggcgcgggcc gagcgccacc ggcgcgcccc cgcccggtcc
     4321 ggtcgctcgc gtcgcggcgg cggccggagc cggtgtcgcg ccgggcgcgg gcgggccggt
     4381 ccggccggcc cgcgcgctca gggtggtccc gcccacgtac tgctcccctc gtcacgcctg
     4441 ttgccgccca atttctcgca tcgggcgaca acagcgatca agcgggacga agggggatct
     4501 gccgggcggg accggacgtc aagtacgttg ccccgggcgc ccattgggct cccatcaggg
     4561 ctttcggtac ggaagcgttc cgacgggccg cacacttcgg ctcaccggaa accacccgaa
     4621 ccggtgagtg tgacgacacg cgcccaaggt gacggaagtg acgcggcgtc acttctccat
     4681 gtgggcggcg agcttggcga gcagcgcgtc gtagatccgc ccgagaccct tcggcgcgaa
     4741 ggtccgctcg aagaagccgc cgacgccgcc ggcgccctgc caggtcgtgg tgacgacgac
     4801 cttggcgcgc ttctcaccgg ccggggtgac gacccaggtg gtcaccatgg aggagttgcg
     4861 gtccttctcc acgagctggc cctcggtcgg ctcgtcgacc tccagcaggc agtcgcgcac
     4921 ccgcttgctc gtggcctgga gcttccagtg aacgagggtg cccttgccgt cgccgccctc
     4981 gcggacctcg tactcgctga agtgctccgg cagcagctgc cggcgcgtgc cggcgtagtc
     5041 ggcgagcgcg tcgaacacgt cctccgggtc cgccgcgatc tcgcgctgcg tggtggcctc
     5101 gacctgcccc atgtgcgtct tcctccagta gtcggctgcc ggtcctgcga tcgccgccaa
     5161 gccaaccacc actggggggc acgcccaaaa tccgggttga cgaaccacaa gggaacacgt
     5221 gttctattat gacgaacggg gggtcggcag gatccagaag gaggcccgat gcgctgggaa
     5281 aatctgggcg aaagcccctc cgcgctgttc ggcacggacg tcgtcagccg gacgatcgac
     5341 acccccgagt tccgcgggat caccttccac gaggtacgcg cccgctcgat cgtcaaccgc
     5401 gtaccgggcg cctcccggat gccgttcgaa tggacggtga acccctaccg cggctgcagt
     5461 cacgcctgcg tctactgctt cgcccgcaag acgcacagct atctcgacct ggacaccggg
     5521 ctgggcttcg actcccagat cgtggtgaag gtcaacgccc ccgagctgct ccgccgcgag
     5581 ctggccgggc gccgctggcg cggcgagcac atagcgatgg gcacgaacgt cgactgctac
     5641 cagcgcgccg agggccgcta ccgcctgatg cccggcatcc tcgcggcgct gcgcgaccac
     5701 gccaacccgt tctcgatcct caccaagggc acgctgatcc tgcgcgacct ggagctgctc
     5761 cggcagtccg ccgcggtcac cgacatcggc atctcggtct ccgtcggctt cctggaccgc
     5821 gagctgtggc gcacggtcga gcccggcacc ccggcaccgg accgccggct ggacgtggtg
     5881 cgtacgctga ccgcgcacgg catcccgtgc ggtgtcctga tggccccggt gatcccgttc
     5941 ctcggcgaca ccccggagca gttgcgggcc acggtccgcg ccgtcgcgga ggcgggcgcg
     6001 ggctccgtca ccccgctggt gctgcacctg cggcccggcg cccgggagtg gttcatggcc
     6061 tggctgggcc accaccaccc ccagctggtg cggcgctacg agacgatgta cgcggacggc
     6121 gcctacgcgc ccaagtggta ccagcgccgg atcacccgcc aggtccacga actcgccacg
     6181 gagtacggca tcgggccgac ccggccgggc gcggcccgcc gcatcccgcc gcccccggtc
     6241 cccgcggccg acccggccgg aaccgccgcg gaacccaccc agttgaccct gctctgacgc
     6301 ctgacggcgg cccggcagga ccgcccgctc accccgcggg gaccaccgcg tccagggccc
     6361 gcgccagacg gtcgcgcgcc tccgtctggg cggcgatccg ctcgtcgatc gcggcgagcc
     6421 gctcacgggc gatccgcagc ccctcggcgg acggcggggc ggtggtcagg tcgccgtcca
     6481 ggcacacggc gaagcaccgg acgtcggcga gggtgagccc ggccgtcagc agatgccgga
     6541 tgttgcgcac ccgtacggcc gtgcgcgcgt cgtagacgcg atagccgttc gcgccccgct
     6601 cggaggcgat cagcccctcg cgctcgtaat ggcgcagcgc gcgcggcgac gcgccggtga
     6661 tccgcgccag ttcgccgatc cgcatcaggg ctccttccgg gggccgccgg tttccgcacc
     6721 gttctacagg acggccggcg gacggaaacc gtcagcccac caccgctccc ccgtcgaccg
     6781 gcagcaccac cccggtcacg aacgaggcgg cgggcgcggc gagccgggtg acggcccagg
     6841 ccacctcttc ggggcggccc acccggccca tgggtgtgtg cgcgatctgc cacttccgta
     6901 cggccgcccg ctgctccgcg gaccagccct ggtgcagcgc gatcggcgtc tcgatcgcgc
     6961 cgggagcgac cgcgacgacc cggacgccgc gcggtgcgag ttccaccgcc cagctgcggg
     7021 tgaggagttc gagggcggtc ttggtcgccg cgtagaccgc gttgccgggc cagccccgct
     7081 ggccgacgga ggtgctgacg ttgaccacca ccccaccggt ccgctccagg tgcggcaggg
     7141 cctcctgggt gagcagcacg ggggcgacga gattcgtcgc caggaggggc gccatgccct
     7201 cccgggtgta gctgccgagc gcgccgtcgc ccaccaccgc ggcgttgttg accagtacgt
     7261 cgagccggcc gtaccgctcc accgcgtggc ggacgacggc ctcgggtgcc ccgtccgcgg
     7321 tgatgtcggc gacgcagggc gtgatcccgc cgcccccgga gccgtccgtc gccgctgccg
     7381 cgtcggccgc ccccgccagc ggctcggccc ggcggcccac cgccaccacc cgtgccccct
     7441 ccgccgcgaa ggcgagcgcg gtggcgcgtc cgatgccggt accggccccg gtgacgagca
     7501 cgaccctgcg atccgatccc gttccgggca tgtccggccc ggtctgcgtg gtgcgttcca
     7561 tgccggaagt ctcaaaccct gacgcctgtg acaaggtcaa gcggcacctc ccccgtcggc
     7621 cggccggact ccccgcggac cgcggcgctc tcggtaatcc gcttgaccgt gcccctaccc
     7681 tctccggcat gaacagttcc acgggcagta cgcgttccgg gcaccggcag ccgcaccccg
     7741 tgcgcatacg ggagatgacc gaggccgatg tcgacggggt ctcggcggtc cgggtccgcg
     7801 gctggcaggc ggcctaccgc gggctgatgc cgcaggcgta tctggacgcg atgagcgtga
     7861 cggcggacgc cgagcggcgg cggtcgtggt tcgcgcgccg gtcaccggag gtggccgacc
     7921 tggtggcgga ggcggccggc gaggtgatcg gctgggcgtc ggtcggcccg gcccgtgatc
     7981 ccgacatcgc cccgggcgcc gaggagttgc ccgcgccccg gccgaccgcc ggtgagctgt
     8041 tcgccctgta cgtgacgccc cggctgatcg gcaccggcgt cggacgcgcc ctgctggccg
     8101 ccgccacgga ccacgccggg acgaaggggt tccgcgccct ctacctgtgg gtggtccgcg
     8161 gcaacacccg ggcccggcgg ttctacgagc gggccggctt cgaaccggac ggggtggagg
     8221 agacgtacga ggtgggcggc cggagcgtcc ccgagctgcg ttaccggcgc ccgctgaccg
     8281 cggggacgcc gtagccacgg tggacaccgt cggggacgct ggagcggcgg cccccgaagt
     8341 ccatgatcgg acggcgtgcg gcgaacgcgc cgtgcgcccg tttgcctcct tctgaggttt
     8401 atgactcctg ggcgcgagtc cgcccccttt cacgccgtat cggcgtgccc tccctcctgt
     8461 ttggcttact cctgcacacg gccacctcgt tccccaccgg ccgttctgct cacttctgtt
     8521 cacgtcccgg gagggaaagt gtccgtaccg gacagtgtca ccggttccgc caccgacgag
     8581 cccgctctcg aaccatccgc agacggtgcg cccaccagcc tcggcacaca ggccgcgcgt
     8641 cagctggcga ccaccaccaa gtccgagccc cagatgcagg ccatcacctc gcggtggctg
     8701 ctgaagtcgc tgccgtgggt ggacgtcaag ggtggcacct accgggtcaa ccggcgtctg
     8761 caactccgcg tcggccgggg ccgtgtcgag ttcgagcaga acggtgcgga cgacatcagg
     8821 gtgatcccgc ggacgctcac cgagctgccc gccctgcgcg gctacgacga cggcgaggtc
     8881 ctcaaggaga tcgccggccg cttccgggtc cgggaggtgc gggccggcca ggtgctcttc
     8941 gaggccgggg agcccgccac cgaggcgtac ctcgtcgtgc acggccgctt cgcccgctac
     9001 acggccggca agtacggcga ggaggaggtc atcggcgtcg tcacggacgg cgaccagatg
     9061 ggggacgagg cgctcggccg gcccgccccg ctgtggcaga gctcggtacg ggccgagacg
     9121 gccggtgtcc tgatggtgct gccctgggac gtgctgcggg agttcaccga ccgggtgccg
     9181 tccctggccg cccatctgac ggcgtacgcg gagcggcagc agcgccccgt gaaccgcaag
     9241 ggcgaggcgg aggttccggt gcgggcgggc cacgtcggcg agcccacgct gtccggcggc
     9301 ttcgtcgact acgacctcgc cccgcgcgag tacgagctct ccctgaccca gaccgtgctg
     9361 cgggtgcaca gccgggtcgc cgacctctac aacgagccga tggaccagac ccagcagcaa
     9421 ctccgcctca ccgtggagga gatccgcgag cgccaggagt gggagctggt caacaaccgg
     9481 gagttcgggc tgctgcacaa cgccgactac gggcagcgga tcagcaccta cagcggcccg
     9541 cccacccccg acgacatgga cgagctgttg tccatgcgcc gcaagacacg gctgttcctg
     9601 gcccacccga aggcgatcgc cgccttcttc cggcagtgca acaagcgcgg cctggtgccg
     9661 ggcaccgcga acgtcgacgg gcacgaggtc cccgcctggc gcggcgtccc gatcttcccg
     9721 tgcggcaaga tcccgatcag cgagacgcac accagcagca tcatcgcgct gcgcaccggt
     9781 gaggcggacc agggcgtcgt cggcctgtac cagaccggcc tccccgagga gttccagccc
     9841 ggcctcaatg tccgcttcat ggggatcgac caggccgccg tcatcaagta cctcgtcacg
     9901 gcctactact cgctggccat cctcgtgccc gacgcggccg gggtcctgga gaacgtccag
     9961 atcggccgga acgccgactg acccggtgga gtcccgaacc atgagcacgc ccccgcacac
    10021 caccgccggg ttcaccctgc ccggcccgcc gagaatcgcc cccgcgccgc ggaaccggcg
    10081 cggcggcgcc gtccccgggc tgaggtaccg gcccgccgcc cccgccgacc ccgagaaggt
    10141 cagggagatc gaccgcagac tggagacctg ggcccgcgag ctggatctgt tcccctcgga
    10201 gtggagcggg gacttcgcgg agttccagtt cggccgggcc gtcgtcctcc agcaccccgg
    10261 tgccgccgac ctcgaacgcc tcaccgccgc gggcaagttg ctgctggcgg agaacatcgt
    10321 cgacaactgc tactgcgagg aggacgaggg caggggcggc gcgcaccgcg gcctgggcgg
    10381 ccggctgatc ctggcccaat cggccctcga cccgtaccac ggcacccccg aacacgaggc
    10441 ggagtggcgc cgcggcgtgc aggccgacgg gccgctgcgc tcgtaccacg tggccctgaa
    10501 ggactacgcg gccctcgcca cccccagcca gaccgaccgg ttcgtccacg acatcgcccg
    10561 gctgcacctc ggctacctcg ccgaggccgc ctgggcggag acgcggcacg cgcccaaggt
    10621 ctgggagtac ctggtgatgc ggcagttcaa caacttccgc ccctgtctgt ccatcgtcga
    10681 cgccatcgac ggctacgagc tgcccgaggc gctctacgcc cgtcccgaga tccagcgggt
    10741 caccgcgctg gcctgcaacg ccacgaccat cgtcaacgac ctgtactcgt tcaccaggga
    10801 gctggcgagc gatccccacc acctgaacct gccgcaagtg gtcgccgcca acgaccaacg
    10861 cggactgaag gccgcgtacc tgaagagcgt cgagatccac aaccagatca tggaggcgtt
    10921 cgagacggag tcggccctgc tggccgccac ctctcccctc gtcgaacggt acctccaggg
    10981 cctggccgac tgggtctccg gcaaccacga gtggcacgcc accaacaccg accgctacca
    11041 gctgccgaac tactggtaga ccgcaccgcg caccacagca aggagtcacc gttgaccatc
    11101 gcgcacgccg acaccgcccg cacaccggtg ccgacccagt ccacgtacca gtcccgcgtc
    11161 gcggactact ggaacgccga ggaaaacccg gtcaacctcg aactcggaaa gatcgacgac
    11221 ctctaccacc accactacgg catcggggac gccgaccggt cggtgctcga cgagccggac
    11281 cccgaccggc gccgggagcg ggtcaccgcc gaactgcacc gtctggaaca cgcccaggcc
    11341 gaactcctcg cctcccacct cggcgacgtc tcccccgccg accgggtctt cgacgccggg
    11401 tgcggacgcg gtggtggcag cgtggtcgcg caccagcgct acggctgcca caccgacggg
    11461 gccaccatct ccgccaagca ggcggacttc gccaacgagc aggcccgcaa gcgcggcatc
    11521 gacgacaagg tgcgctacca ccaccgcaac atgctcgaca ccggcttcac cgccggcgcg
    11581 tacgcggcgt cctggaacaa cgagtcgtcc atgtacgtcg agctggacct gctcttcgcc
    11641 gagcacgcgc ggctgctgcg gcgcggggga cgctatgtgg tgatcaccgg ctgctacaac
    11701 gacgcctacg ggcgcgcctc ccgcgaggtg tcgctgatca acgcccacta catctgcgac
    11761 atccatcccc gctctgcgta cttccgcgcg atggcccgca accggctcgt gccggtgcac
    11821 gtcgaggacc tgacggcggc cgcgctgccg tactgggagc tgcgccggga ggccgaccat
    11881 ctggtcaccg gcatcgagga caccttcctc aacgcctacc gcaacggcag cttccagtac
    11941 ctgctgatcg ccgccgaccg ggtgtgagga cgccggggcc gcgtcgcgcg tcggcgcggc
    12001 gcggccccgg cgaggtcctc aggtctcccg ctccgccggc gtggtcccgc tgccgcgctg
    12061 ctccggcacc tcgtgcaccc ccagccgtgc cagcgacgcc gccgcggcgg cggccagccg
    12121 ggggtgcgcg acagcggcgg tgagcgccgg gacggcccgc cggtcgccca gcgcgcccag
    12181 gccctccacg caggcgagcg ccacccgcca gtaggggttg tgcggggtca gcagccgctc
    12241 cagcgtcgcg atcagcgccg gtacggactg gggcgcgcgc agctcggcga gcaaccggac
    12301 cgggtgcagg gcgtaggcgg tgcgcagcgg gttggtggcg agcgcggccg ccgcacgagc
    12361 ggtccgcggg tcgccgagcc ggctcagcgc gtgcgcggcg gtcgcgcagc gcaccggatc
    12421 gcggtagttc agcagcagga cgagcgtctc gaaggcgcgc ttgtcgccgg cgcagccgag
    12481 gatgaacgcg gcgatctccc tggcccacag cgggcgttcc acggcgacca gcatccgggc
    12541 cagctcctcc cgcccggcgg gggtgttctt gcgggccagc cccagtaacc gctcgtaggc
    12601 gaccaggtcc tgtggggagc ggagttcggc ccgcacccgg tccgtcaact cgtggaattc
    12661 gtcttccatt tgccgcttcc ctcccgccgg gccgccccgg tccctgcgac gtggcctgca
    12721 ccacagccta atgaccccga ctacccctgg cgctctggtt acccaccggt taacctgctg
    12781 ggacgagcag cacccctgct cgggcggcct ggtgacgcag ccgccacaga gtgaagtcgg
    12841 ttcggcacag cacgacacac ctacggagac gacggcacgg ccccgggaca gggcccgccc
    12901 cacctccgct cccgccggcg ctgccagcag cgctgcggcc gctcgcggcg tcctgccgcg
    12961 gctccgccgc cgcgcctttc ccaggccacg cgtccgcgcg gacaccctca gtcgtcactt
    13021 ctcccctgcc ttcaggggaa caccctcagg agtctcgcga tgggccctca ctccacccct
    13081 gatctgccaa ctgaagccgc ccccttgtcc ctggccaccg tggccgtcgt cgggctgggc
    13141 accatgggca ccggcctcgc cgaggtcctg acccgggccg gccgcgaggt catcggcatc
    13201 gacaccgacg aagccgcggc ccgccgtgcc gtcgccgccc tggaggccgc caccgcccgc
    13261 gcggtgcggc gggagcggat caccgagcgc gagcgccagg acgcgctggc ccgcttccgc
    13321 accttcaccg acctgcaggc cgccgcggac gccgacctcg tcatcgaggt ggtgcccgag
    13381 gactacgacc tcaagcgccg ggtcttcgcc gaactggacg ccgtggtgcg cccggacgcc
    13441 atcctcgcca ccggcaccaa cgccctgtcc gtgacccggc tcgcggccga ctcgcagcgc
    13501 cccgagcggg tgctcggcgt gcacttcttc aaccccgcgc cggccatgaa gctggtcgag
    13561 gtggtctcct cggtcctcac cgcgccgacc gcggtcgcgg ccgtcaccca gctcgcccgc
    13621 gacctgggca aggaccccat cgcggtcggc gaccggcccg gattcgtcgc cgacggcctg
    13681 ctcttcggct acctcaacca ggccgcggcg atgtacgagt ccaagtacgc gacccgggag
    13741 gacatcgacg ccgcgatgcg gctcggctgc ggtctgccca tgggcccgct ggcactgctc
    13801 gacctgatcg gtgtggacac cgcccgtacg gtcctggagg cgatgtacgc cgagtcccag
    13861 gaccggctgc acgcgcccgc cccgatcctg gggcagctgg ccgaggccgg gctgaccggc
    13921 cgcaaggcgg gccgcggctt ctacacctac gaggcccccg gcagcggcac ggtggtcccg
    13981 gacgcggaga gcccggcccc cgccgacgcg ctcggcaccg gccgtacggt cgccgccgtg
    14041 ggcgtcgccg ggtccggcac gatggcgagc ggcatcgccg aggtgttcgc caaggcgggc
    14101 ttcaaggtcg tgctggccgc ccgcagcgcg gagaaggcgg agcaggccaa ggcccggatc
    14161 gccaagtcgc tggggcgctc ggtggacaag ggccggatga ccgccgaggc ccgggacgcc
    14221 gcgctggacg cgatcacccc ggccgggtcg ctcgacgcgt tcggcgacgt ggatctggcg
    14281 gtcgaggcgg tggccgagga cctcgcggtc aagcaggagc tgttccggac gctggacaag
    14341 gtctgcaagc ccggcgccgt gctggccacc acgacctcgt cgctgcccgt cgtcgcctgc
    14401 gcccgcgcca cctcgcgccc gcaggacgtc atcggcatgc acttcttcaa cccggcaccc
    14461 gccatgaagc tggtcgaggt ggtgcgtacg gtcctgacgg ccgacgacgt gcacgccacc
    14521 gtgcgggcgg tctgcaccaa ggtccgcaag cacccggtgg actgcggcga ccgggccgga
    14581 ttcatcgtga acgcgctgct gttcccgtac ctgaacaacg cgatcaagat ggtcgagcag
    14641 cactacgcga ccctcgacga catcgacgcc gccatgaagc tcggcggcgg ctacccgatg
    14701 ggccccttcg aactcctcga cgtggtcggc ctggacgtgt ccctggccat cgagaaggtg
    14761 ctgcacgccg agttccgcga cccggggctc gccccggcgc cgctgctgga gcacctcgtc
    14821 gcggccggct gcctcggccg caagaccggt cgcggcttcc gtgagtacgc ccggcgctga
    14881 cccgtggcgc cacccccgcc cggcaggggg aggctggggt ggactgctgg aacccgatgg
    14941 cggtccaccc ccgctcacaa gggcggtggc ggcacctcat gccgcaggtc gcgtaaatat
    15001 gcagtaccgt ccccacatgt cccagcccgc tcgtacgcag ccctccgaca cccccgacgc
    15061 cacttctccc ggcactcgcc gcgcggccgc gcaacggctc aagatgcgcc gcgaattgtc
    15121 ggcggcggcc atggagctgt tcgcgaccaa gggctacgag gcgacgacgg tcgacgagat
    15181 cgcggcggcc gcgggcgtcg cccggcgcac cttcttccgc cacttccgct ccaaggaaga
    15241 ggcgatcttc cccgaccacg acgacaccct cgtacgggcc gaggccgtcc tggacgccgc
    15301 cccgccgcac gagaacccgc tcgacacggt ctgccgcggc atcaaggagg tcatgcggat
    15361 gtacgcggcc tccccggccg tctcggtggc ccgctaccgc ctcacccgcg aggtacccac
    15421 cctccgggag gccgagatcg cctcggtggc ccgctacgag cggctgttca cccgctatct
    15481 gctgggccac ttcgacgagg gcgcgcaccg cgagggcgac gacgacccgc tgctcgccga
    15541 ggtcgccgcg tccgccgtgg tcaccgcgca caaccacgtc ctgcggcgct ggctgcgggc
    15601 cggcgcggag ggcgatgtcg aggcacagct cgaccacgcc ttcgagatcg tccgggagac
    15661 cttcggcgcc ggcatcggcg ccggccgcac caccaccggg gagcagcccc cggcggccgt
    15721 ctccagggag ggcgaggtgc tggtcgcggt ggcccgcacg gacgccccgc tggaggaggt
    15781 catgcgcacg atccgcaagg ccatcaagga acggaagtag cggcggcacc tccaccaccg
    15841 cacaccgtcg cggcccggag cccgggcacg gaccgggccg cgacccgaac ggcctaatcc
    15901 cgcctctgcg tacgctgcgc agtggcggga tttctttgcg tgacgaccat gcctccgatc
    15961 ggggcatctg ttgctcatgc gtgccccccg gatgacatct gagagaaatt cttggcactc
    16021 agtgtcttgt cgactggcac gcggtgtcat acgttgaggg tgtccgggcg gccggcgcgc
    16081 agcgaaccat cgcgcgccgg ctgtcccacc agccgtacgc ggctggccgc ccggacgcct
    16141 gcgtcacagg cacccccagc agccgctggg caccgcgctc accacagcgc tgccaggcac
    16201 cgcggccgac ggctctgcga ccaccgcaga ggcgacggaa gcggcgccac cccggccgaa
    16261 ccgacggcac cacctcccgc tccacccccg acgttccctc aagccgtttc ccagaaaaac
    16321 gagcttcgcc ggaggcacac cgtgaacaag atcctggacg caatcctctc ccccgacgcg
    16381 accggtgcgg acttcgccgc actgcccctc cccgagtcct accgcgcggt gaccgtgcac
    16441 aaggacgagg ccgagatgtt cgccggcctg cccacgaagg acaaggaccc ccgcaagtcg
    16501 ctgcacgtcg aggacgtgcc ggtgcccgaa ctcggccccg gtgaggcgct ggtggccgtg
    16561 atggcctcct ccgtgaacta caactccgtg tggacctcga tcttcgagcc gctctcgacg
    16621 ttcgggttcc tggagcgcta cggcaagctc tccccgctca ccaagcgcca tgacctgccg
    16681 taccacgtca tcggctccga cctggccggc gtcgtgctgc gcaccggtcc cggcgtcaac
    16741 gcctggggcc ccggcgacga ggtcgtcgcg cactgcctgt ccgtcgagct ggagtcctcc
    16801 gacggccaca acgacacgat gctcgacccc gagcagcgca tctggggctt cgagaccaac
    16861 ttcggcggac tggccgagat cgcgctggtc aagtccaacc agctgatgcc caagcccaag
    16921 cacctgagct gggaggaggc ggcggcgccg ggcctggtga actccaccgc gtaccgccag
    16981 ctggtctccc gcaacggcgc cggcatgaag cagggcgaca acgtcctgat ctggggcgcc
    17041 agcggcggac tcggctcgta cgccacgcag ttcgcgctgg ccggcggcgc caacccgatc
    17101 tgtgtcgtct ccagcgagca gaaggcggac atctgccgcg cgatgggcgc cgaggcgatc
    17161 atcgaccgca gcgccgaggg ctacaagttc tggaaggacg agcagaccca ggaccccaag
    17221 gagtggaagc gcttcggcaa gcgcatccgc gagttcaccg gcggcgagga catcgacatc
    17281 gtcttcgagc accccggccg cgagaccttc ggcgcgagcg tctacgtcac ccgcaagggc
    17341 ggcaccatca ccacctgcgc ctcgacctcg ggctacatgc acgagtacga caaccgctac
    17401 ctgtggatgt cgctgaagcg catcatcggc tcgcacttcg ccaactaccg cgaggcgtgg
    17461 gaggccaacc gcctgatcgc caagggcaag atccacccca ccctgtcgaa gacctacagc
    17521 ctcgacgaga ccggccaggc ggcgtacgac gtgcaccgca acctccacca gggcaaggtc
    17581 ggcgtgctgg cgctggcgcc cgaggagggc atgggagtgc gcgatgagga aatgcgcgcc
    17641 aagcacctcg acgccatcaa ccggttccgg aacgtctgag cctctcgggc tttcctgaac
    17701 cccgaagata cgggcctgat atgactgagc gtcagaagga tcgtccgtgg ctgatgcgga
    17761 cctacgccgg ccactccacc gccgaggcgt ccaacgagct gtaccggcgt aatctcgcca
    17821 agggccagac cggtctgtcg gtcgcgttcg accttccgac gcagaccggt tacgaccccg
    17881 accacatcct cgcccgcggc gaggtcggcc gggtcggggt cccggtgtcc cacctcggcg
    17941 acatgcggcg gctgttccag gacatacccc tggaccagat gaacacctcc atgaccatca
    18001 acgcgacggc catgtggctg ctggcgctgt acgaggtggt cgccgaggag cagggtgccg
    18061 acatcagcaa gctgtcgggc accacgcaga acgacatcgt caaggaatac ctctcgcgcg
    18121 ggacccacgt cttcccgccg gggccgtcgc tgcggctgac caccgacatg atcacgtaca
    18181 cggtggcgca catccccaag tggaacccga tcaacatctg cagctaccac ctgcaggagg
    18241 ccggggccac gccggtgcag gagatcgcgt atgccatgtc caccgccatc gcggtgctgg
    18301 acgcggtgcg cgactccggc caggtgccgc cggagaagtt cggcgacgtc gtggcccgca
    18361 tctcgttctt cgtgaacgcg ggcgtccggt tcgtcgagga gatgtgcaag atgcgcgcct
    18421 tcggccgcat ctgggacaag atcacccgcg agcgctacgg catccggaac gagaagcagc
    18481 gccggttccg ctacggcgtc caggtcaact cgctcgggct gaccgaggcg cagccggaga
    18541 acaacgtcca gcgcatcgtg ctggagatgc tggccgtgac gctctccaag gacgcccgcg
    18601 cccgcgccgt ccagctcccg gcctggaacg aggcgctggg cctgccccgc ccctgggacc
    18661 agcagtggtc gctgcgcatc cagcaggtcc tggcgcacga gagcgacctg ctggagtacg
    18721 aggacatctt cgccggctcg cacgtcatcg aggccaaggt cgacgccctg gtcaccgact
    18781 gcctcgcgga gatcgagcgg atccaggaga tgggcggcgc gatggccgcg gtggagtccg
    18841 gctacctcaa gtcgcagctg gtctccgcgc acgccgagcg gcgggcccgg atcgaggccg
    18901 gcgaggagaa gatcgtcggc gtcaactgct tcgagggcac cgagcccaac ccgctcaccg
    18961 cggacctcga cacggccatc atgaccgtcg acccggccaa cgaggcacgc gtggtgcagg
    19021 ggctgcacga ctggcgggac aaccgcgacg agacgcgcgc ccaggaggcg ctgtcggtgc
    19081 tgaagaagac cgcggcgggc gacgccaacc tcttcgccgc gaccctggag tgcgcccgcg
    19141 ccggcgtcac gacgggtgag tgggcctggg cgctgcggga cgtcttcggc gagttccggg
    19201 cacccaccgg cgtctccagc gctcccctgg cggtcgccgc cgaggcgggc agcccgctgg
    19261 ccgcggtccg cgagaaggtc gccaagacgg cggccgagct cggcaccggc aagctgcggc
    19321 tgctggtcgg caagcccggc ctggacggtc acagcaacgg cgccgagcag atcgcggtac
    19381 gggccaggga cgccggcttc gaggtgatct accaggggat ccggctcacc ccggagcaga
    19441 tcgtctcggc ggcggtcgcc gaggacgtgc actgcgtggg cctgtccatc ctgtccggct
    19501 cgcacgccga gctggtgccg gacgtcctgg accggctgcg ccgcaccggc gtcgacgacg
    19561 tacccgtcat cgtcggcggc atcattccct cggccgacgc caccgcgctg cgggaagccg
    19621 gagtggcggc cgtcttcacc cccaaggact tcggcatcac ggagatcatc ggtcgtatcg
    19681 tcgacgagat ccggaaagcc aaccagctcg accccctgga ggtccccgca tgacagcccc
    19741 tgtcacccgc ctgcggcccc gtcgctcctg tctcgcggtt cccggcagca atccgcgctt
    19801 tctggagaag gcccagggcc tcccggcgga ccaggtcttc ctggacctgg aggacgcctg
    19861 cgccccgctc gccaaggagg gcgcccggca ctccgtcgtc gaggcgctga acggcggcga
    19921 ctggaccggc aagacccggg tcgtacgggt caacgactgg acgacgcact ggacgtaccg
    19981 ggacgtcatc acggtcgtcg agggcgcggg gcccaacctc gactgcctca tgctgcccaa
    20041 ggtccaggac gcccagcaga tcgtggcgct ggacctgctg ctgacccaga tcgagaagac
    20101 catgggcttc gaggtcggcc ggatcggcat cgaggcgcag atcgagaacg ccaagggcct
    20161 ggtgaacgtc gacgagatcg ccggcgcctc gccgcgcctg gagaccatca tcttcggccc
    20221 ggccgacttc atggcatcga tcaacatgaa gtccctggtg gtcggggagc agccgcccgg
    20281 ctatggcgcc gatgcgtatc actacattct gatgcgcatt ctgatggccg cacgggccaa
    20341 cgatttgcag gctatcgacg gcccgtacct tcagattaag aacattgatg gctatcgcga
    20401 ggtggccggc cgggccgccg ccctcggttt cgacggcaag tgggtactgc atccgggtca
    20461 ggtcgaggcc gccaatgagg tgttctcgcc gtcccaggag gactacgacc acgccgagct
    20521 gatcctggac gcctacgagt ggcacacctc ggaggcgggc ggcaagaagg ggtcggcgat
    20581 gctcggtgac gagatgatcg acgaggcgag ccggaagatg gcgctcgtcg tcgccggcaa
    20641 gggccgggcc gcaggcatga tccgtacatc caagttcgaa gccccggagg catgagcgcg
    20701 atgcagttcg gccgtaccta tgaggaattc accgtcggcg atgtctacaa gcactggccg
    20761 gggaagaccg tcaccgaata cgacgaccac ctcttctgcc tgctcacgat gaatcaccac
    20821 ccgctgcaca tggacagcaa ctacgcggag cagaccaccg acttcggcaa gaacgtcgtg
    20881 gtcggcaact acatctattc gctgctgctg ggcatgtcgg tgccggacgt ctccggaaag
    20941 gccatcgcca atctggaaat cgagtcgctg aagcacgtgg cgccgacctt ccacggcgac
    21001 acgctctacg gtgagacgac ggtgctcgac aagacgccgt cgaagtccaa gacggaccg
//
