LOCUS       NZ_CP017157            21035 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces lydicus strain 103 chromosome, complete genome.
ACCESSION   NZ_CP017157
VERSION     NZ_CP017157.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lydicus
  ORGANISM  Streptomyces lydicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Complete genome sequencing of Streptomyces lydicus 103 and metabolic
            pathways analysis of antibiotic biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2016) Key Laboratory of Systems Bioengineering
            (Ministry of Education), Tianjin University, Tianjin 300072, PR
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001729485.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:23:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,288
            CDSs (total)                      :: 7,195
            Genes (coding)                    :: 7,061
            CDSs (with protein)               :: 7,061
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 47 of 134
            Pseudo Genes (incomplete)         :: 104 of 134
            Pseudo Genes (internal stop)      :: 11 of 134
            Pseudo Genes (multiple problems)  :: 26 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:52:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4365863
            Orig. end                         :: 4386898
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017157.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA is available from Prof. Ying-Jin Yuan.
            Annotation modified by submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21035
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="15"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21035
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21035
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11035](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11035)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            374..1768
                     /locus_tag="SL103_RS18910"
                     /old_locus_tag="SL103_18910"
     CDS             374..1768
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021498.4"
                     /locus_tag="SL103_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18910"
                     /product="Wadjet anti-phage system protein JetD
                     domain-containing protein"
                     /protein_id="WP_164492850.1"
                     /transl_table=11
                     /translation="MGANGAGSLELLFSEAQGRVRVSVAGTPEGTVALSVPVRREGVNR
                     PPRNRQGLLRIQEVDLVTAYTQSAYDPPSLLESRHLIWVLSAGRRSWATIASRFKDEAW
                     SVAVALIRSGGVVLRCAVDEDLELAEPLSWRLSHSWALQAEELLQELRGWRDPYEVRKE
                     LLTLMTPVPELNSERALLEGCSEGAALRVPSGSAVRTEAWTTYEAAVRAASVWWPAQVA
                     EERLSAKELAGLALGGSKKWTPARQTAFENLVGMSFDLAVDEADIDIRVRGPLQWRVGA
                     VAADAAVANPWIALPAGALRLVGEVEYRGRGVFLVENSDTFERVCAMPEVTSRWLCVWG
                     KGYVTNQLVALLEWMQPERLAIWGDLDADGIAIIADLSQRLGRRVHAVGMEVELWRAGP
                     YRQQEPEQYLKAQALAAQMAVEGPVELRALASEIAVTGESCEQEPLHRKVLPRLVKLLG
                     GVPAGG"
     misc_feature    1742..1744
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1761..3035
                     /locus_tag="SL103_RS18915"
                     /old_locus_tag="SL103_18915"
     CDS             1761..3035
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS18915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SL103_18915"
                     /product="hypothetical protein"
                     /protein_id="WP_164492851.1"
                     /transl_table=11
                     /translation="MDEQLAFGDGEQAELAAAVQLANWRAFMAPVAEDAGAVARHPEVA
                     RVALAILKVFAEHSGPHGLTRAEVLEALADEPQGWPTELVERRLTVLASLGFLEPYLLK
                     AHQDRYVVRPAGLAGALAAERLAEHGGVDELILLLDRARAVFDRSNPDPEAALDYLVSC
                     RNALRVFALDLQRLVATGTLVELMEAQRQHDHQGFTRQVNELNDVVTSRFSGNWALEEA
                     ASALIEAEQFYRRQVMASADKVLAQGGGSLNFDVLTVSEYTEAAIKGDVALLSQVGAAL
                     VGDAPPVWIDPAQVLETVSGFTPRSSGRGRPLVVDDAGPEEEPWEWAEGAHARVLEDRR
                     LLADELLAGGQEVDLTPALYAAGWPGAASILTDVLALGDEPGEPYSVVVEDALLGDPAA
                     SVTYLHPLLLRKRVVGGEAGGGDGV"
     gene            3130..4311
                     /locus_tag="SL103_RS18920"
                     /old_locus_tag="SL103_18920"
     CDS             3130..4311
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SL103_18920"
                     /product="hypothetical protein"
                     /protein_id="WP_164492852.1"
                     /transl_table=11
                     /translation="MAEPVLGQAATAAGASGRRVLRVGDMGTDDLVVLGWDAETAPVAG
                     IPMAGWRVGLAPVATLAWAACLRAAWPRPELQPFPGVPFRRADVMSLCAGLGADEDTVK
                     RAVDGVLQEAHFVVAHGDVLRLGPAVAALPAVVVEGLRRGHHLLPALGAEESAGGQERG
                     AEGVPALEVGDGDPLVGETVDEHLIRSVIATLETARVPLPRANLPMLADPALRARVEAT
                     LGRCGRQLLQTEEGNWITGFLNPVTDALVAEGVGTLGDVERAVLALVLLHTVALPRAQG
                     RHRHSRWTGESHTVTLAVLASNRKITKTAISAALRRLKGAGLVAEKTAGRYLPGPALDR
                     LTAERSNLLWEDLVLVGRPDGHLAAAIRRRRQPDVRPAREADTSGGRAERGTV"
     gene            4308..7454
                     /locus_tag="SL103_RS18925"
                     /old_locus_tag="SL103_18925"
     CDS             4308..7454
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SL103_18925"
                     /product="hypothetical protein"
                     /protein_id="WP_069570161.1"
                     /transl_table=11
                     /translation="MSEQPSGGALGKLGVIGTRQLVAVQTFFIARLTSHPVALVPGTFV
                     AVTGRGPKDSNESGKTSFLAAVALLLGDPEWRMTGGGSVHAPKLLFEPVTAGASPEVSE
                     PAQVGYVVGVFADPEDPQVSAHTVWLQVSAKSPHVEVRHRAGVHLLVDGDDRSQHEGAA
                     SFFRRLGGKPLGAMEYAEVLYGRAPRLLAYIVSRGGMRSRPSLLKLDAGTFTPVQIGDA
                     LVNLTGRAGMLARDVQDRQELEQTQKDLAEALKNAESSYRDEEQILHAVATRERARLET
                     GRAHELWRLASARDYVDTVVAERRIETHLIMFAGLLEELSERESGVGKQLAEARDTRLL
                     ERTAKDARQLKIQAQRLLEEANEKRGELHGALKGVEKEQRAAQARAEGYDGPTSAELAE
                     LLATHQGDLVAAKADLLRADERVDKTGRELADAREGRTGQTAAVLQALHAGPCPGAVGL
                     MASTRLHPDARSLWEARLAPWSDAVCVPPSLLDAAVEAVRDFPGTVLIAGPPAGALPAR
                     PAAGWPAGIADAAPLARSFLQALADATTVEQPPHASLPSLGVHVVGGFERPIVGQADIC
                     AHLEEQLVRERAEQDAVSAAIGLCERRLTALSRDIDRAKAKEVASRLADQAHNLEEALA
                     AHDETLPGLRSSAATAAEAAVRAGDAFEGATKRVQGLLESVQKVKKEIGQTTQKRDRML
                     ELRGKGPAHPGLVWTDSLPEALAALNWSAVPPDEVGAEPTQGISIHAVVPGDRERAVER
                     RISGELLGESRARLSSALARLSADSHSTGVATPELANALHHQEAHIEDPHGAIFRDSLS
                     ALVTWLADNEEQDRGAREQVDVKRAERATEHRYLQDIVEETREGLAQTQQSIKERVLGS
                     LRRISDKLNELHSREGYKADLLCDVTEPQTAQDQWVCHVVPRWQRNPNGPLLPYDRPTN
                     TAQEKLFSIHLVLAALLAAPDARGRILILDELGDSLGAEHRREVIAALRDAAQDHGITV
                     LATCQDVLMTDVRLICGQILQFRYYSKSDALNRPTLMFGLDDNGRRVQLTLDALVSSRA
                     "
     misc_feature    5847..5849
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6393..6395
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6441..6443
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7667..7843
                     /locus_tag="SL103_RS37955"
     CDS             7667..7843
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS37955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164492853.1"
                     /transl_table=11
                     /translation="MLNRLFDAASRYRTRISLKPVVAAAHWAWPVLDDGGELARIAAAS
                     ADRGRRLGHLPAA"
     misc_feature    7845..7861
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.57"
                     /tool="antismash"
     gene            8606..9037
                     /locus_tag="SL103_RS18930"
                     /old_locus_tag="SL103_18930"
     CDS             8606..9037
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS18930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SL103_18930"
                     /product="hypothetical protein"
                     /protein_id="WP_164492854.1"
                     /transl_table=11
                     /translation="MALELDFDPGIAWIGGEPLELRWRGARGKRRWRPDFMVRTVSGTG
                     HAVVVAPDKDDGPQWRENLEVLDEVAPASGWRIPVHHVPAKMRLENLELAGEYRKPVPV
                     PAEEQEALEAAFCRERPMQRERWHVACRRGLLWIWRTGW"
     gene            complement(10001..11035)
                     /locus_tag="SL103_RS18935"
                     /old_locus_tag="SL103_18935"
     CDS             complement(10001..11035)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="SL103_RS18935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18935"
                     /product="hypothetical protein"
                     /protein_id="WP_164492855.1"
                     /sec_met_domain="T1TS (E-value: 9.6e-57, bitscore: 192.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPANGIHPQAEKVGERSVEWLAGFGIFDSDGSLRRQIVASRVGEA
                     VGRAAPLASDAGLQLYADWSAAAFTFDDFYCDMGPTSTRPDEFLEVAMRVLYRIERPEA
                     ARWDETLLSDAFADLSRRVRSLAPMMWPSWVTGHKDWVLGSVCGIAQRTGARGRPADIA
                     DHLATRVSDGAMSLNHALIEMAEGTRLPDELRGGPTVAAATAAAYTLVLLANDLVSYRR
                     EAEAGATNTNCVTLLAPTGGSVEDGMEKVVRLHDRIMSLYIRLSHQLKATRDERLRRYI
                     DQLSTYIRANLDWSLTVPRYRAHPSSGASVSAAVTGWSTEPSDGSLAAPPIPSIAWWWE
                     QLRA"
     misc_feature    complement(10993..11009)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    11185..11199
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    11337..11352
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            11468..12706
                     /locus_tag="SL103_RS18940"
                     /old_locus_tag="SL103_18940"
     CDS             11468..12706
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019886332.1"
                     /locus_tag="SL103_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18940"
                     /product="cytochrome P450"
                     /protein_id="WP_069570164.1"
                     /transl_table=11
                     /translation="MAVYERLREEYGAVAPVRVHDDLPAWLVLGYRENVEVARNEARYS
                     RDPQIWREALAGRVRADHPLSPMITWWPVVNFTDGAVHRRLSDAIKEALRRFEELGIRR
                     YVDRCALELINRFPNGRVDLVADFAVQLPMLVMSNLIGLPEEAGPRLVEAVPDMLQGTE
                     TSVESDRYVTDLLQQLVESKKSHPGHDLTSMLLKHPSQLTDQEVLAHVRIILVAACETT
                     TTLIANTLRMVLTDQRFRAHLSGGQMTLPDAVEQMLWDQPPLNTVIGRWAVADVELGGQ
                     QIRAGDMLLLGLAAGNADPVVRPPEDELSAPIYANRSHLSFSKGAHECPGQEIGRSIAQ
                     AGVDTLLARLDGLALAVPAAELRRNGTLMSQHLVNLPVTFRPLQATNAATEKGRVPGYA
                     SREHSALTDVPAP"
     misc_feature    13013..13023
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            13066..13910
                     /locus_tag="SL103_RS36305"
                     /pseudo=""
     CDS             13066..13910
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377534.1"
                     /locus_tag="SL103_RS36305"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPLTDVHWGRIQPLLPDRTPKRVGRLRDHREVIDAITFKFQTGTQ
                     WVHLPEKYGNWRDVYNRLRMWALDGTWEQVITALMTQADADEDLTWAVPMDSTIVRAHQ
                     HAAGARKKGPGRRTSRSCHRPIPQRTEHKDPPRCRWLLPTPGLRSHRRAGW"
     misc_feature    13072..13074
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14916..15128)
                     /locus_tag="SL103_RS18950"
                     /old_locus_tag="SL103_18950"
     CDS             complement(14916..15128)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009316408.1"
                     /locus_tag="SL103_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18950"
                     /product="DUF4287 domain-containing protein"
                     /protein_id="WP_069570165.1"
                     /transl_table=11
                     /translation="MTAPVKGPASYFPSIEKKYGRPIEEWKELIRTSPLTKHMELVAWL
                     KSEHGLGHGHANALVAHTLAERDSS"
     gene            complement(15197..15868)
                     /locus_tag="SL103_RS18955"
                     /old_locus_tag="SL103_18955"
     CDS             complement(15197..15868)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010644701.1"
                     /locus_tag="SL103_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18955"
                     /product="DUF998 domain-containing protein"
                     /protein_id="WP_069570166.1"
                     /transl_table=11
                     /translation="MTQALRVPLTGRAASTSSTTRALLTGGALAGPLFLGVGLIEGLTR
                     DGFDFTRNALSQLSLGSVGWIQVANFLVTGALVTAGAVGLRRAIGHTAGGTWVPRLIGV
                     FGASFLLAGVFTADPGAGFPAGTPDGPATLSGHGTVHMLSGMVGYLALCAAFLVLARHF
                     AVQGRRGWALAYRLLPLGIMAGFVGSATTVVAFTAAAGLGLLALTTAIARLSGPAPTAQ
                     Q"
     gene            15995..16618
                     /locus_tag="SL103_RS18960"
                     /old_locus_tag="SL103_18960"
     CDS             15995..16618
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374043.1"
                     /locus_tag="SL103_RS18960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18960"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069570167.1"
                     /transl_table=11
                     /translation="MEANEPVSRSARKHQAIMEAATAVFMEKGYAGTSMDDIAKLAAVS
                     KQTVYKHFADKEKLFAEIVLATTDRVEDMIDLVADIPADADSLEENLLRLARQFLSTLT
                     QPEVLQLRRLIIANADTFPDLGATWYEQGFERVLATLAETFQRLADRGLLRIDDPVLAA
                     HHFSGLLLWIPVNRAMFHGSPQHNESELEHYADAGIRTFLAAYR"
     gene            complement(17109..17939)
                     /locus_tag="SL103_RS18965"
                     /old_locus_tag="SL103_18965"
     CDS             complement(17109..17939)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542853.1"
                     /locus_tag="SL103_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18965"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_069570168.1"
                     /transl_table=11
                     /translation="MKTILVLGGTGKTGRRIARRLKAAGLPVRTASRTAGDPHLDLDDP
                     ASWTPALDGVTAAYLVEPSLSASTDHQARIPRLVTEAVAAGVRRLVLLSAPRAGEEGHP
                     LHVAEQAVRDSGVGWTILRPQWFAQNFSEGPWRPAILAGTLALPTGDGRTPFVDAEDIA
                     EVAAAALTEDRHNGRVYDLTGPRAISFGEAAGLIARATDRTIRHVDVEPEDFVQRQVAA
                     GAAPDVARLLTELLVALGNGSGAALSDDVERALGRPPRAFETFVTEAAAAGHWN"
     gene            18021..18962
                     /locus_tag="SL103_RS18970"
                     /old_locus_tag="SL103_18970"
     CDS             18021..18962
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542854.1"
                     /locus_tag="SL103_RS18970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18970"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_069570169.1"
                     /transl_table=11
                     /translation="MDVLSDLLHRARARNALVRQLIQRPPWSLSFTDPPPLTVVTTLAG
                     HASVRIDDAGTAPVRLAAGDIALITGPGGYTIADDPSTPPQVVIHGRRKSVADGAPETP
                     ATQRNLAPRTYGDGLPGATVMLRGAYHLRGDVGDRLLGTLPPLAVVPAGPATRAALDLL
                     GTEATRDEPGQDAVLDRLLDLLLVLALRAWCAGAETAPAWYRALADPAIGEALHLLHAD
                     SARRWTVAELATQVGMSRAAFAARFTALVGEPPLTYLTGWRMTVAADLLRDAETTVAAV
                     AHHVGYEDPFAFSVAFKRIRGVSPSIWRRQTH"
     gene            complement(19008..19901)
                     /locus_tag="SL103_RS18975"
                     /old_locus_tag="SL103_18975"
     CDS             complement(19008..19901)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057576.1"
                     /locus_tag="SL103_RS18975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_18975"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_069570170.1"
                     /transl_table=11
                     /translation="MDISSVGLRVLQQIAESGSFTAAATRLGYTQSAVSRQAAALERNA
                     GATLFERRPDGVRLTPAGLTLLRHARTILDSVAAAERDLTGTSPQTELVRLGAFLSAGA
                     VLLPAALKRLATTDPHITVTTREGTTPSLIRALRAGSIDLAVLTSRPPHRPPDGESPPL
                     HVETVEDTELVVAASSTGEFAGRTTVHVDELVDAAWIATPSSSSEPLLGVWPGLPGRPR
                     IVHSARDWLTKLHLVAGGFGVTTLPSRLSPVLPPGVSLLHVEGAPPEVRRILVARLPGH
                     PHPAVTAVTRAIKSPA"
ORIGIN
        1 cccgccaccc ccgccccaca cccttcctcc ggcggacacc gacaccgact gccgtgccga
       61 cgcgcagcca ccgaaggatc aaaagtgccg ttcccgcgac agcggagcgg agtgggctgt
      121 accgccccat gacagccgca cccgcctcag aatccacccc catggcagtg acctcgctct
      181 tcctcaacac ccgaccagcg aagacctccc aatccgacat gtcatcactg acactcaccc
      241 actcacacca aaccgggaca tcgcagctgc gccccacgtt gatggttgtg agagacaagc
      301 cggtctgagt gtgtcttgct gactgagtgg atatgccttt ggtctgagtt ggaagtggat
      361 tcgaggggga tatgtgggcg ccaacggggc tggctcgctg gagctgttgt tcagcgaagc
      421 acagggacgc gtccgggtat cggtggccgg gacgccggaa ggcaccgttg cactgtccgt
      481 tccggtacgt cgtgaggggg tgaatcggcc tcctcgcaac cgccagggcc tcctacggat
      541 ccaggaagtt gatctggtga ctgcttacac gcagtccgct tatgaccctc caagtctctt
      601 ggagagccgg cacttgatct gggtgttgtc agccggacgg agatcgtggg ccaccatcgc
      661 ctctcgcttc aaggacgagg cgtggtccgt tgcggtggcg ttgatccgga gtggcggtgt
      721 cgtactgcgg tgcgcagttg acgaggactt ggagctcgcg gagccgctga gctggcgact
      781 gtctcattcg tgggcgctgc aggcggagga gttgttgcag gagttgcggg ggtggcggga
      841 cccctatgaa gtgcgcaagg agctgcttac gctaatgacg cctgttcctg aactgaacag
      901 tgaacgggcg ctgttggagg ggtgctcgga aggggccgcg cttcgggttc cgtcgggaag
      961 cgcggttcgg acggaggcgt ggacgacgta cgaagccgct gtgcgggcgg cgtcggtgtg
     1021 gtggccggcg caggtggctg aagagcggtt gtcggctaag gagttggccg gccttgctct
     1081 gggtggttcg aagaagtgga cccctgctcg gcagacggcc tttgagaact tggttgggat
     1141 gagcttcgac ctggcggtcg atgaagctga catcgatatt cgcgtgaggg ggccgttgca
     1201 gtggcgggtg ggggcggtgg ctgccgatgc cgcggtggcc aatccgtgga ttgctctgcc
     1261 tgctggcgcg ttgcggctgg tgggggaagt tgagtacagg ggccggggtg tgtttctcgt
     1321 cgaaaactcg gacacctttg agcgtgtgtg tgcgatgcct gaggttacgt cgcggtggct
     1381 gtgtgtttgg ggcaaggggt acgtcacgaa tcagctcgtt gcgctgctgg agtggatgca
     1441 gccggagcgg ttggcgatct ggggggatct ggatgccgac gggatcgcga tcattgccga
     1501 tctctctcag cggctcggcc ggagggtgca cgcggtgggg atggaggtgg agttgtggcg
     1561 tgctgggccg taccggcagc aggagcctga gcagtacctg aaggcccagg cgttggcagc
     1621 gcagatggcc gtcgaggggc ccgtggagct acgggcgttg gcgtcggaga tcgcagtgac
     1681 gggtgagtca tgcgagcagg agcctttgca taggaaggtg ctgcctcgtc tggtgaagct
     1741 gttaggtggg gtgccggccg gtggatgagc agctcgcgtt tggtgatggt gagcaggcgg
     1801 agttggctgc ggcggtgcag ttggccaact ggcgggcttt catggctcct gtggccgagg
     1861 acgcgggcgc cgtggcgagg catcccgagg tggctcgggt ggcacttgcg atcttgaagg
     1921 tgtttgcgga gcattccggt ccgcatgggc tgacccgggc tgaggtgctg gaggcgctgg
     1981 cggatgaacc gcaggggtgg cccacagagt tggtcgagcg tcggctgacg gtgttggcga
     2041 gtcttgggtt tcttgagccg tacttgctga aggctcatca ggatcggtat gtggtacgtc
     2101 ctgcggggtt ggcaggggct ttggctgccg agaggttggc tgagcacggg ggcgtcgacg
     2161 agttgatctt gttgttggac cgggcgcggg ctgtgttcga tcgcagcaat cccgatcctg
     2221 aggcggcttt ggactacctg gtctcgtgcc gcaatgcgtt gcgggtcttc gcgttggatc
     2281 tacagaggct ggtggcgacg gggacgctgg ttgagctgat ggaggcgcaa cggcagcatg
     2341 atcatcaggg gttcacgcgt caggtgaacg agctgaacga tgtcgtgacg agtcggttca
     2401 gtggcaattg ggcgttggag gaggcggctt cggctctgat tgaggcggag caattctacc
     2461 ggcggcaggt catggcgtcg gccgacaagg tgctcgcgca gggcggcggc agtctgaact
     2521 ttgatgttct gacggtgagc gagtacaccg aggctgcgat caagggcgac gtcgcgctgt
     2581 tgtctcaggt gggtgcggcg ctcgtcgggg acgcaccacc ggtgtggatt gatcccgcgc
     2641 aggtgctgga gacggtgtcg ggttttactc cgcgctcaag cggacggggc cgtcctctcg
     2701 tggtggacga cgctgggccg gaagaggagc cctgggagtg ggctgaaggg gcgcatgctc
     2761 gcgtgttgga ggaccgtcgt ctcttggctg atgaactgct ggccgggggc caagaggtgg
     2821 atctcacccc ggctctgtat gcggcgggct ggccgggggc cgcgtcgatc ctgacggatg
     2881 ttctggcgtt gggagacgag ccgggtgagc cgtacagcgt cgtcgtggag gacgcgctgc
     2941 tgggcgaccc ggcggcttct gtcacgtact tgcacccgtt gctgctgcgc aagcgggttg
     3001 tgggcggaga agcgggcggt ggggacggtg tttgagggag gctcttcgtc tggggcgcag
     3061 gcagcggagg agctgcaggc gcaggtgctg ttggggcggt tgcgtgctcg gggtgtggcg
     3121 tcggctgctg tggccgagcc cgtgttgggg caggcggcga ccgcggcggg tgcgagcgga
     3181 cgccgggtgc tgcgtgtcgg tgatatgggg acagacgatc tggtggtgct gggatgggat
     3241 gcggagacag ctcccgtcgc cgggattccg atggcggggt ggcgggtggg gctggcgccg
     3301 gtggcgacgc tggcgtgggc ggcgtgtctg cgtgcagcat ggccacgccc ggaactgcag
     3361 ccgttcccgg gagtgccctt ccggcgagcg gacgtgatgt cgctgtgcgc ggggttgggg
     3421 gcggatgagg acacggtgaa gcgggccgta gacggagtcc tgcaggaggc ccacttcgtt
     3481 gtggcgcacg gggatgtgct gcggctgggg ccggccgtcg cggcgttgcc ggctgtggtg
     3541 gtggaagggc tccggcgcgg gcatcatctg ctgcccgcgc tgggcgcgga ggaatcggcc
     3601 ggtgggcagg agcggggtgc ggagggggtg ccggcgctgg aggtcggtga cggggacccc
     3661 ctggtggggg aaacggttga cgagcatctg atccggtcgg tgatcgccac cctggagacc
     3721 gctcgggttc ctttgccgcg ggcgaacttg cccatgctgg ctgatccggc actgcgggcc
     3781 cgggtcgaag cgactctcgg gcgttgcgga cgacagctgc tgcagacgga agagggcaac
     3841 tggatcactg gcttccttaa tcctgtcacc gatgcgctgg tggccgaggg ggtcggcacg
     3901 ctgggcgatg tggagcgggc ggtcttggct ctggtactcc tgcacacggt ggcactcccc
     3961 cgtgctcagg ggcggcaccg gcacagccgg tggaccggcg aatcgcacac ggtcaccctg
     4021 gcggtgctcg cttccaacag gaagatcacc aaaacggcga tcagtgcggc actgcgccgt
     4081 ctcaagggag cgggcttggt tgcggagaag actgcaggcc ggtatctgcc ggggcctgct
     4141 ctggaccggc tgactgcgga gcgcagcaac ctgctgtggg aggacctggt cctcgtgggc
     4201 cggcccgacg gtcatctcgc tgccgcgatc agacgtcgcc gacagccgga tgtccgccct
     4261 gctcgcgagg ccgatacctc cgggggccgc gcggagaggg gaactgtgtg agcgagcaac
     4321 cctccggtgg cgccctcggg aagcttgggg tgatcggtac gaggcagttg gtggccgtgc
     4381 agacgttctt catcgcgcga ttgacctcac atcctgtggc tcttgttccc ggcacgtttg
     4441 tggccgtgac gggccggggg ccgaaggatt ccaacgagtc gggcaagaca agcttcctgg
     4501 ctgcggtggc gctgttgttg ggagatccgg agtggcggat gacagggggc ggctcggtgc
     4561 atgcgccgaa gctgctgttc gagcccgtga cggccggagc gtcgccagag gtcagtgagc
     4621 ccgctcaggt gggctacgtg gtgggggtct ttgctgatcc tgaggatcct caggtcagtg
     4681 ctcacacggt atggctgcag gtatcggcga agtcgccgca tgtcgaggtg cggcacagag
     4741 cgggggtgca tctgctggtt gatggggacg accgcagtca gcacgagggg gctgccagct
     4801 tcttccgcag gctcggcggg aaaccattgg gtgcgatgga gtacgccgaa gttctgtacg
     4861 ggcgtgcgcc gcggctgctc gcctacatcg tcagccgcgg cggcatgcgg tcgcggccgt
     4921 cgctgctgaa gctggacgcg ggtacgttca cgccggtcca gatcggggat gccttggtca
     4981 atctcacggg cagagccggg atgctggccc gtgacgtgca ggatcgccag gagttggagc
     5041 agacccagaa ggacctggct gaggcgctga agaatgcgga gagttcctac cgagatgaag
     5101 agcagatcct ccacgctgta gcgacccggg aacgtgcacg cctcgagacg ggccgggcgc
     5161 atgaactgtg gcggcttgct tcggcacgcg actacgtgga cacggtggtc gccgagcgcc
     5221 gcatcgagac ccatctcatc atgttcgccg ggttgttgga ggagttgtcg gagcgtgaga
     5281 gcggtgtggg gaagcagttg gccgaggcgc gcgacacgcg tctgctggaa cgcacggcca
     5341 aagatgcccg ccagctcaag atccaggctc agcggctctt ggaggaagcc aatgaaaagc
     5401 ggggagaact ccacggggct ctcaaagggg tggaaaagga gcagcgcgcc gcacaggcgc
     5461 gggctgaggg atacgacggg ccgacgtcgg ccgagctcgc tgaacttctc gccacgcacc
     5521 aaggtgacct tgtagcggcg aaagcggatc tgctgcgggc cgacgagcgg gtcgacaaga
     5581 cgggccggga gctggctgat gcccgtgagg gacgcacggg ccagacggct gctgttctgc
     5641 aggcgctgca cgctggcccg tgccccggcg cggtggggct catggccagc acgcgtctgc
     5701 atcccgatgc ccgctccctg tgggaggcgc ggctggctcc atggagcgat gcggtctgtg
     5761 ttcccccgag cctattggac gctgcggtgg aggccgtccg ggactttccg gggacagtgc
     5821 tcatcgccgg gcccccggcc ggtgccttac cggctcgtcc tgccgcgggc tggccggcgg
     5881 gcatcgccga cgcggccccg ttggcacgct ccttcctgca ggccctggcc gacgcgacca
     5941 ccgtggagca gccgccgcac gcctctctcc cgagtctggg agtgcatgtc gtcggcggct
     6001 tcgagcggcc gatcgtcggg caggctgaca tctgtgctca cctcgaggaa cagcttgtcc
     6061 gggaacgcgc cgagcaggat gctgtctcag ctgcgatcgg actgtgtgaa cgccggctca
     6121 ccgcgctgag ccgggacatc gaccgggcga aggcgaagga ggtggcatca cggctcgccg
     6181 atcaggcaca caacctggag gaggccctcg ccgcgcacga cgagacgctg cccgggctca
     6241 ggagcagcgc agcgactgcc gccgaggcag ccgtgcgcgc tggggacgca ttcgagggcg
     6301 cgacgaagcg tgtccagggc ttgctggagt cggttcagaa ggtcaagaag gagatcggac
     6361 agacgacgca gaagcgcgac cgcatgctcg agttacgggg aaagggaccg gctcaccccg
     6421 gtctggtctg gacggattcg ttaccggagg ctctggcagc gttgaactgg agcgcggttc
     6481 ccccggacga ggtgggcgcc gaacccaccc agggcatcag catccatgca gtcgttcctg
     6541 gtgatcggga gcgggcggtc gagcggcgca tcagcggcga gctcctcggg gaaagccggg
     6601 cccgcctgtc ctcggcactc gcccgcctgt cggcggactc ccacagcacc ggcgtcgcca
     6661 cccccgaact agccaacgct ctgcaccatc aggaagccca tatcgaagac ccccacggcg
     6721 ccatcttccg cgactcgctc tcggcgctgg tgacctggct ggccgacaat gaggagcagg
     6781 acaggggcgc tcgcgaacag gtagacgtca agcgcgccga gcgcgccacc gagcaccgct
     6841 acctccagga catcgtcgag gagacgcgcg agggcctcgc ccagacccaa cagtccatca
     6901 aggaacgcgt cctgggctcc ctgcgccgca tcagcgacaa gctcaacgag ctccacagcc
     6961 gcgaggggta caaagctgat ctgctgtgcg atgtcacgga gccgcagacc gcgcaggacc
     7021 aatgggtgtg ccatgtcgtt ccgcggtggc agcgcaaccc caacggcccg ctactgccct
     7081 atgacaggcc gaccaacacc gctcaggaga agctgttctc cattcacctc gtcctggccg
     7141 ccttgctggc ggcgccggac gcccgcggcc gcattctgat cctcgatgaa ctcggcgact
     7201 ccctgggcgc cgagcatcgc cgggaagtca ttgcggctct gcgtgacgcg gcccaggatc
     7261 acggcatcac tgtcctggcc acctgccagg acgtgctgat gaccgatgtg cggctcatct
     7321 gcggtcagat cctgcagttc cgctactact ccaagtccga cgccctcaac cggcccaccc
     7381 tcatgttcgg gctcgatgac aacggccggc gtgtccagct cacactcgac gcgctggtca
     7441 gcagccgcgc ctgacctgcc ttatctggcg cctcccctca cgctgacatg agaagcgtga
     7501 gaccggctct ggcgctcagg cagcaaggcc attcggtcct cgggtgagct cagccggaat
     7561 taggtgcgct gttcccgtcc ggggtccgcg tcgacggctg attcttcgac ccgccccgcg
     7621 atgcctgggt ggtgcgtctg ggcgccttcg acgccgaggt ctgacgatgc tgaaccgtct
     7681 gttcgacgcc gcgtcccgct accgcacccg gatcagcctc aagcccgtcg tcgccgccgc
     7741 gcactgggca tggcccgtcc tcgacgacgg cggcgagctg gcccggatcg cggcggcgtc
     7801 cgcagaccgc gggcggcgcc tgggccacct gcccgcggcc tgacctgccg ccgacttgca
     7861 aaggtcacgt tgtgcggatg cgggtgcacc cttgcggcat gtgggcacat cgtccgcttg
     7921 gcggactgcg gatccatctc tcggcctggc cgtgaggctc ccgggcgcag cacgttgcac
     7981 gaggcccgca gaaccgctga aggccgcccg gtgactgccg ggcggccttc aggagtgtct
     8041 gcaccctggg tgtgtggcct gcccctctcg gggctaccag ggacggggcc agggtcttca
     8101 ctactcagtg cactgatccc ccacactcga cgaggtccac aggccggcag gggggtgagc
     8161 cttctctgcg gcacctgtgc agcggccggt ccgtgcctgc ccgtattcct caaagacgac
     8221 ccggccccgc cgggcaggcg tagaccgccg ctctgggcac aacgtccgtt cccgggcgcc
     8281 gcccggatct cggaaccggc ccctttgcca agtcatgccc ctccctggag ggaaatcctg
     8341 ccgcacatcc gggcgtgtcc tgcccggcaa tggccacctg aaagcgcccc acgagggagg
     8401 ccatgcgcat ggttaccgcg caccatctgg acaagcgggg gcagttggtg tccgtcgcgc
     8461 ccgccgagct ggtggggtag cactggagga gcgccgtccc tcaacgaagc cggtggccta
     8521 ccgagggcgc ccgggcaagc tgtcgaactg gtggtgcgcg acgaccggca gccatgtggt
     8581 gtgcgggtcg ctgcgggtcc gcggggtggc cctcgagctg gacttcgacc cgggcatcgc
     8641 ctggatcggc ggggaaccgt tggagctgcg ctggcggggc gcgcggggca agcgccgctg
     8701 gcgccccgac ttcatggtgc ggaccgtcag tgggacgggg cacgcggtgg tcgtcgcacc
     8761 agacaaggat gacgggccac agtggcggga gaacctggag gtgctagacg aagtcgcccc
     8821 agcctcaggc tggcggatac cggtgcacca cgtgccggca aagatgcgcc tggagaatct
     8881 ggagctggcg ggcgagtacc ggaaaccggt gccagtcccg gccgaggagc aggaggcgct
     8941 ggaggcggcc ttctgtcgcg aacgccccat gcagagggag cgttggcatg tggcatgccg
     9001 caggggcctg ctatggatct ggcgtaccgg ctggtaacgg cagcggcgcc tggcggtgca
     9061 ctgggaccgg ccgctggggc cgtgggcgac cgcctggcgt aggccacggc gtgagcgccg
     9121 cggagggatt cacgccgggg caggtgcgtc tgggcgatgg ggtgcggtgg ctggacggcg
     9181 cctaccaggt ggtcgcctgg aggtaattgt tgcagtagaa ggagtcgagg ggttctcggt
     9241 cgacccgaaa gatggttcgc cggaagtggc cttcctgcgg cctatgaaag ggtaggcgaa
     9301 gagttgaaga tgcagtactg gaggtcatga atcgtcagcg ccagaaggct ggcgagtact
     9361 tcattggccg ggttgtgctc ggcgatatgg gcgcagaagc gccaggggcc ctcggtggcg
     9421 gaggctgctg agagcgtgag cccgaggctg ggctgggatg catgccccag gcatgaccgc
     9481 gcagcatcac ctggtcagga ccgtatttct ggccatagtg ccagccgttc tcccgcttca
     9541 gcttcgctgg ccggggctgc ttgccgaact gcttgcgtcc tcgcggtgtt gcaacaacat
     9601 accgtcagcg cattcaggcg gccacgcctg gtaccgacca cgacacttcc aacgcaccgt
     9661 cattccggta gtcccctagc aggcccggac ctcacgcctc gctgacgagt cgacgaggtg
     9721 caggcacgcc gccgcggacg tcgccgcgct gcagcgcacg aggttgcctc ctgccggagc
     9781 cgacgcctgg tgacttcggc gtggtgaggc aactctgatg cccgagacaa ccgccttgtg
     9841 tcgaactcca tgcctgcccc ccgccgtcat gaggcggcgg gcagcaggca cgtccgatgt
     9901 gtttgcactg ccgggtcgct gctgccgaga gcctggacgc aacgggctcc cagccgcatc
     9961 cgcactgaat gctttctgcg ctcggtgcgg cgacgggcgg tcaggcgcgg agctgctccc
    10021 accaccacgc gatggagggg atcggcggag cagcgaggct gccgtcagag ggctcggtgg
    10081 accagccggt caccgcggcg gagacggagg cgccgctgga ggggtgggct cggtaacggg
    10141 gaacggtcag ggaccagtcc aggttggccc gtatgtacgt gctcaactgg tcgatgtagc
    10201 gcctgagtcg ctcgtcgcgg gtggccttga gctggtggct cagccggatg tagagcgaca
    10261 tgatgcggtc gtgcagccgc acgactttct ccatgccgtc ctccacgctg ccgccagtag
    10321 gggcgagaag ggtgacgcag ttggtattgg tggcaccggc ctccgcctcc cggcggtagg
    10381 agacgaggtc gttggccagc aggacgaggg tgtatgccgc cgcggtggcg gcagcaacag
    10441 tgggcccgcc gcgcagctca tcgggaagcc tggtgccctc ggccatctcg atgagcgcgt
    10501 gattgaggga catcgcgccg tcgctgaccc gcgtcgcgag gtggtcggct atgtccgccg
    10561 gtctgccgcg ggccccggtg cgctgcgcta tgccgcagac ggacccgagg acccagtctt
    10621 tgtgccccgt cacccagctc ggccacatca tcggtgcgag gctgcggacc cggcgcgaga
    10681 ggtcggcgaa ggcatcggac aggagcgtct catcccagcg tgcggcctcg ggccgctcaa
    10741 tgcggtacag cacacgcatc gcgacttcca ggaactcatc cgggcgggtg ctggtggggc
    10801 ccatatcgca gtagaagtcg tcaaaagtga aggccgccgc cgaccagtcc gcgtacaact
    10861 gcagccccgc gtcggacgcc agtggtgccg cgcgacctac agcctcaccc acccggctcg
    10921 cgacgatctg ccgccgaagc gagccgtcac tgtcgaatat cccgaagccg gcgagccact
    10981 ccacgctgcg ttcgccgact ttttcagcct gcggatggat cccgttcgcg ggcacgatcg
    11041 ggcagtacac ccgcggaact cccacgggcc aggtcaccag cgatgtctca tatgggtgcg
    11101 cctcgctggt tggtgcgtct tgcccggtgc cgtacacgga acctccctgg tcgccgcagg
    11161 gcgcgcccgt gccctgctca tacttgatca ttttgcacac tcggatggct gaaaataccg
    11221 cgctgccaca tctggacggc taaggtccca gcacgggtgg acaaggtggc ccacctcaac
    11281 ggcgcttttc ggcgcccaat gcacctgtcc tcaaaagccc atgaccagga gtcagggcga
    11341 acgtgtgtgc cagctatgct ccggtttcat gaacatcccc cctggctcgc cgccgcccca
    11401 gtgcccggca cacgcacacg acggaagtcc gctgcgtctg gacgggccgg aggcccaggc
    11461 ggaccccatg gccgtgtacg aacgtctccg cgaggagtac ggcgcggtcg cgcccgtacg
    11521 agtgcatgac gaccttccgg cctggctggt gctcggctat cgcgagaacg tggaggttgc
    11581 acgcaacgaa gcgcgctact cccgtgaccc ccagatatgg cgggaggcgc tggcggggag
    11641 ggtccgcgca gaccacccgc tgagccccat gatcacctgg tggcccgtgg tcaacttcac
    11701 cgacggcgct gtgcacaggc gcctcagtga cgcgatcaag gaggcactga ggcgcttcga
    11761 agaactcggc atccgccgct atgtcgaccg ctgtgcgctc gagctgatca accggtttcc
    11821 gaacggccgg gttgacctcg tggcagactt cgccgtccag cttccgatgc ttgtcatgtc
    11881 gaatctcatc ggcctgcccg aagaagccgg accgaggctt gtcgaggcgg tgcctgacat
    11941 gctgcagggg acggagacct ccgtggagag cgacaggtac gtcaccgacc tgctccaaca
    12001 gctcgtcgag agcaagaaga gccaccccgg ccacgacctg acctccatgc tgctgaagca
    12061 cccctcacag ctgacggatc aggaggttct cgcgcacgtg aggatcatcc tggtcgccgc
    12121 atgcgaaacg acgaccaccc tcatcgcgaa caccctgcga atggtcctta ccgaccagcg
    12181 attccgagcc cacctttccg gcgggcagat gaccctgccc gacgcggtag agcagatgct
    12241 gtgggaccag cctccgctca acacggtgat cggccggtgg gctgtggcag atgtggaact
    12301 gggcgggcaa cagatccggg ccggcgacat gctcctcctg ggcctggctg ccggcaacgc
    12361 agacccagtg gtccggccgc ccgaggacga gctttcggcg cccatctacg ccaacaggag
    12421 ccacctgtcc ttctccaaag gcgcccacga gtgcccgggg caggagatcg gacgctccat
    12481 tgcccaagcg ggcgtggaca cgctgctggc acgcctggac ggtcttgcac tcgcagtgcc
    12541 cgccgcggaa ttgcgtcgca acggcacgct gatgtcccag cacctcgtga accttccggt
    12601 caccttccgc ccgctgcagg ccaccaacgc agccacagag aaggggcgcg taccgggcta
    12661 cgcgtcgcga gagcacagtg cactgacgga tgtacctgcc ccatgagttt gcatgcagcg
    12721 ccgtgccatt tccttcgtga ggaggtgaac cttgcagtga ggctcacccc tcgtaggcag
    12781 actcaacagt gaccgtgtgg agcatcatgc cgccaacgcc gagcagcacg cgagacacgc
    12841 cgtgctgtcc tcggccagca cggcctgaga ctgaagtggc gctgtggtgc agcgccccag
    12901 ggtgacaccg tccgtcgctt tcgaatcccg tctcgggcca cggcgcgaag ggccggccca
    12961 gcctgccacc acggaccggg cgctgcgtgg ccccctccca gcgcccggtc cgtgctatgt
    13021 gacgactagc cagttccgtt tggttcagtc ggtcgttggt ccggtgtgcc gttaacagat
    13081 gtgcattggg ggcgaattca gccattgctt ccggaccgga cgccgaagcg ggttggacgc
    13141 ttgcgcgacc accgtgaggt gatcgacgcg atcaccttca agttccagac cggaacgcag
    13201 tgggtccacc tgccggagaa atacggcaac tggagagacg tctacaaccg gctgcggatg
    13261 tgggccctcg acggcacctg ggagcaagtg atcaccgcgc tgatgaccca ggccgacgcg
    13321 gacgaggacc tgacctgggc cgtgccgatg gactccacga tcgtgcgagc tcaccagcac
    13381 gcggccgggg cccgcaaaaa ggggcccggc cggagaacca gccgatcatg ccatcggccg
    13441 atcccgcagc ggactgagca caaagatcca cctcgctgca gatggctgct gccgacccct
    13501 ggccttcgtt ctcaccgcag ggcaggctgg tgacgcacct gccttcacgg atctcatggc
    13561 ccgcctacgt gttccccgcc accgcgcaag accgcggacc aggccgaacg tggtcctggc
    13621 agacaaggcg tactcctcat gcgccatacg cgaccacctg cgcaaacgcg gcatccgagc
    13681 ggtgattccc gtcccggcgg atcagcgtag gcaccgactg cgacggggca gccggggcgg
    13741 caggccgcca gccttcgacc gcgagaccta caaaacagcg caacaccgtc gagcggtgca
    13801 tcaaccgact caaacagtgg cgaggcatcg ccacccgcta cgagaagacc gcaaccatct
    13861 acctggctga cctccacatc gcaggcatct tcctctggtc agcccgatga tccaaacgaa
    13921 agtccttagg cgtattcacc tggagtcgcc ccgaccacga cggcctccgt ccgcgcccga
    13981 ggcgcggatg gtgacgctgc gccgcgcccc ggaccgcccg tggcccggcc atgtattgcg
    14041 tcacgagcaa ggtaagctcg ccaccgttcg agagcccagc aggcattgag cgcctccgcg
    14101 gcggccacga tcatcccgga gcggagcgtc ctgccccgct cccccttttg ccgtgtttcc
    14161 acggaagtca actcccctac ctttcaggga ggtcggggga atcgacgatg aatgcgtcta
    14221 cctttcgtgc tccgcccccg tcatcgaccg tgccgtagcc ccacccctgg tactttcctc
    14281 tgcctccgcc aacgcagaat tggtattcga cttctatgtt ctcgccaggc gtatcgaact
    14341 cccgcatcca gttgtgcccg ctgcacacct cttcggcctg agccttgggc ccggtgacga
    14401 caatccccct acggcaaacg acagggccgc caagaaggtt gctgaacgct tgaactgacg
    14461 tgacataagt atcccttcgg cttcgaatcg gcggcgcgtg gttcgttgaa cgtccacagt
    14521 cagggaaagc cctggccggc cccaccatcg cgcctttcgt cgaaccgggg cgctggcgta
    14581 gcgaatggcc gtcgcagcaa ttcgccacac cagcggtggg gagagcctgt tctgcttccg
    14641 gtgaggacag cacacagtct gcggcgtgtg ccgcgcctgc cagggtcccc cgctccagca
    14701 tcacggcgat gcagccagcc ggggccggcc ggtcatgcct gcgaggcccc ctcactgtgg
    14761 ttccttgctc gacacccccg tggtcgagcc ccacgtcagt aaaggattcc ggatcaagcc
    14821 cggcaattcg ttagcactga gtgcacgaag tacttggcgc tcagtgcccc ctgacgtgag
    14881 gctctcagta cgcagcgcac aggcccgagt tcgggtcagc tgctgtcgcg ctcggcgaga
    14941 gtgtgggcga caagggcgtt ggcgtgcccg tgaccgaggc cgtgctcgga cttgagccag
    15001 gcgacgagtt ccatgtgctt ggtcagaggt gacgtgcgga tcagctcctt ccattcctcg
    15061 atcgggcggc cgtacttctt ctcgatggac gggaagtagc tggcggggcc tttcaccggt
    15121 gcggtcatga cgcgacgtcc tgtctgtttg cgtgcggtgt tctcgggtcg gtgtcgtgcg
    15181 agcggggtgg gagccgctac tgctgtgcgg tgggggcggg gccggacagc cgggcaattg
    15241 ctgtggtgag tgcgagcagg ccaaggccgg ctgcggcggt gaaggccacg accgtggtgg
    15301 cggagccgac gaatccggcc atgatcccca gcggcaggag gcggtaggcc agggcccaac
    15361 cgcgccgccc ctggacggcg aaatgccggg ccagcacgag gaatgcggcg cacagtgcga
    15421 ggtaacccac catgccgctg agcatgtgga ccgtcccgtg tccgctcagc gtggccgggc
    15481 cgtccggcgt gccggccggg aatcccgcac cggggtccgc cgtgaacacc ccggcgagca
    15541 ggaaggacgc tccgaagact ccgatcaggc gcggcaccca ggtgccgccg gcggtgtggc
    15601 cgatcgcccg ccgcagtccc accgcgccgg cggtgaccag ggcgccggta accaagaagt
    15661 tggcgacctg gatccagccc acggagccga ggctgagttg gctgagggcg ttgcgggtga
    15721 agtcgaagcc gtcgcgcgtg aggccctcga tcagtcccac ccccaggaac agcgggcccg
    15781 ccagcgcccc gccggtaagc agcgcacgag tggtggacga agtcgaggca gcacggccgg
    15841 tgagcggtac gcggagcgcc tgagtcatct gatatccccc taagccgagg ccaggctcgg
    15901 aactggacgg ttcagtactg ctgaactgga cggtacggta ctcgtagaag aactggactg
    15961 tccagtactg ttttgctcga tccgaggagg gcgtatggaa gcgaacgagc ccgtcagccg
    16021 gtccgcgcgc aagcatcagg cgatcatgga agccgcgacg gcggtcttca tggaaaaggg
    16081 ctacgccggt acgagcatgg acgacatcgc caagctggcc gccgtgtcca agcagacggt
    16141 gtacaagcac ttcgccgaca aggagaagtt gttcgccgag atcgtcctgg ccaccacaga
    16201 tcgagtcgag gacatgatcg acctggtggc cgacatcccc gccgacgcgg actcactgga
    16261 ggagaacctg ctccgactgg cccgccagtt cctgagcacc ctcacccagc ccgaggtgct
    16321 ccaacttcgg cgcctcatca tcgccaacgc cgacaccttc cccgacctgg gtgccacctg
    16381 gtacgagcag ggcttcgagc gggtcctcgc caccctggcc gagaccttcc aacgccttgc
    16441 cgaccggggg ctgctgcgga tcgacgaccc tgttctggcc gcccaccact tctccggtct
    16501 gctgctgtgg atcccggtga acagggccat gttccacggc agtccgcagc acaacgagtc
    16561 cgaactcgag cactacgccg acgcaggcat ccggaccttc ctcgccgcgt accggtgagc
    16621 ccggtcgccg agcaggatta gccgcgccac gtgcaggtct ccggggcgcc ggcagaaggc
    16681 tgttgcggcc cgagtccgtg aacctttcgg ttctcggcga gggccggctg cctcccgacc
    16741 cgtggacagg tgctgtccga atgcgtgagc agagcgagcg gcaggccgca ttcctcggcc
    16801 ctcccgaggg ctacgacgac gtcgacggcg ttccctcgct gctcggcccc gtgccagtgg
    16861 tggaactcgt ccgtgctccc gccggcgtgg gcatcggctc tctgcttgag tgctgccgcc
    16921 cctcccccgg cggccggccc cctgatccgc ccgggggatg tgggattgct gcagagtctg
    16981 tgactgcacg gccccgaagt ctgaggacga cagtccccgg ctggacgggg gaggccagcc
    17041 ggggactgtc ttgcgtgtgc cctgtgtacg gcatcgaaaa cacggcactt gtcccggagg
    17101 acggctcgtc agttccagtg gcccgcggcg gcggcctcgg tgacgaaggt ctcgaaggcg
    17161 cggggcggtc ggccgagggc acgttccacg tcgtcggaga gcgcggcgcc cgagccgttg
    17221 ccgagggcca ccaggagttc cgtgagcagt cgggcgacgt cgggtgcggc gccggcggcg
    17281 acctggcgct ggacgaagtc ctccggttcg acgtcgacgt gacggatcgt gcggtcggtg
    17341 gcccgggcga tgaggccggc cgcctcgccg aagctgatcg cccgtgggcc ggtcaggtcg
    17401 tagacccgtc cgttgtggcg gtcttcggtc agcgccgccg cagcgacctc ggcgatgtcc
    17461 tccgcgtcga cgaacggcgt gcgcccgtcg ccggtgggca gggccagggt tccggcgagg
    17521 atcgcggggc gccagggacc ctcgctgaag ttctgcgcga accactgcgg gcggaggatg
    17581 gtccagccga cgccggagtc acgcacggcc tgctcggcga cgtgcagggg atggccctct
    17641 tcgccggcgc gcggggcgga cagcagcacc aagcgccgta cgcccgcggc gaccgcctcg
    17701 gtcaccaacc gggggatgcg cgcctggtgg tccgtgctcg ccgacaggct cggctccacg
    17761 aggtaggcgg cggtgacgcc atcgagcgcg ggtgtccagc tcgccgggtc gtccaggtcg
    17821 aggtgggggt cgcccgcggt gcgggacgcc gtgcgcacag gtaggccggc ggccttgagg
    17881 cgccgggcga tgcggcggcc ggtcttgccg gtgccgccga ggacgaggat ggtcttcatg
    17941 cagttcagcc aaccccaggg ggcgtggacg atccatggga gaacgtcgcc gcttcctttg
    18001 tgatcgtcta gcgtgggtgg gtggacgtac tcagcgatct gctgcaccgg gcccgggcca
    18061 ggaacgcgtt ggtcagacag ctgatccaac gtcctccgtg gtcgctgagc ttcaccgatc
    18121 cgccaccgct cacggtcgtg accacgctcg ccggccacgc gtcggtgcgg atcgacgacg
    18181 cgggcaccgc cccggtgcgt ctcgccgcgg gcgacatcgc cctcatcacg ggccctggcg
    18241 ggtacaccat cgccgacgac ccttccaccc cgcctcaggt cgtgatccac gggcggagga
    18301 aaagcgtcgc cgacggggcg ccggaaacgc cggccacgca gcggaacttg gctccccgca
    18361 cctacggcga cgggctgccc ggggccacgg tcatgctccg cggcgcctac cacctgcgcg
    18421 gcgacgtcgg cgaccggctg ctcggcacgc tgccgccgct ggcggtcgta cccgccgggc
    18481 cggcgaccag ggcggcactg gacttgctcg gcaccgaggc cacccgtgac gaacccggtc
    18541 aggacgccgt gctggaccgg ctgctggacc tcctgctcgt gctggcgttg cgggcctggt
    18601 gtgccggagc ggagacggcg cccgcctggt accgggcact ggccgatccg gcgatcggcg
    18661 aggcactgca cctgctgcac gcggattccg cccgccggtg gacggtcgcc gagctggcca
    18721 cccaggtcgg catgtcccgg gccgccttcg ccgcccgctt caccgcgttg gtcggcgaac
    18781 ccccgctcac gtacctcacg ggctggcgga tgaccgtggc ggcggacctg ctccgggacg
    18841 ccgagacgac cgtcgccgcc gtggctcacc acgtcgggta cgaggaccct ttcgccttca
    18901 gtgtggcgtt caagcgcata cggggcgtca gcccttcgat ctggcgccgg cagacgcatt
    18961 gaacgggtgc gaacgggttc ccagtcggcg acggcgatga tgatgggtca ggcgggggac
    19021 ttgatcgctc gggtgacagc ggtgaccgcg gggtgggggt ggccggggag gcgcgctacg
    19081 agaatccggc ggacctcggg aggtgcgccc tcgacgtgca gcaggctcac ccctggcggc
    19141 aggaccggcg acagccggga cggcagcgtc gtcacaccga agccgccggc gaccaagtgc
    19201 agcttcgtca gccagtcgcg cgccgagtgg acgatgcgcg ggcgtccggg caagcccggc
    19261 cagacgccga gcagcggttc ggagctcgat gacggggtgg cgatccacgc ggcgtcgacc
    19321 aactcgtcga cgtgcaccgt ggtgcggccc gcgaactctc cggtggaaga cgccgccacg
    19381 accagttcgg tgtcctcgac ggtctcgacg tgcaggggcg gcgactcgcc gtccggcggc
    19441 cggtggggcg gacgggaggt cagcacggcg aggtcgatcg agccggcgcg cagcgcccgg
    19501 atcagactgg gagtggtgcc ctccctcgtc gtgacggtga tgtgcgggtc ggtcgtcgcg
    19561 agccgtttga gcgcggcggg cagcaacacc gcgcccgcgc tcaggaacgc tccgagccgc
    19621 accagttcgg tctgcgggga agtgccggtg aggtcgcgtt cggcagccgc gacggaatca
    19681 aggatcgtgc gggcgtgccg cagcagggtc agcccggcgg gggtgagccg caccccgtcg
    19741 ggacggcgtt cgaacagggt ggcacccgcg ttgcgttcga gggcagcggc ctgacgtgag
    19801 accgccgact gcgtgtagcc gagtcgggtg gccgccgcgg tgaagctgcc ggactctgcg
    19861 atctgctgca ggacccgtag gcccacgctg gagatgtcca tgcgtagtac gcataccaca
    19921 catgcaggat cgtcgcttcc cgcatgcctg ccgggcgcct agcgtctctc ccggtggaca
    19981 gcgaagaaca ctgaagaaca ccgaagaagc ctgacgaagc cccacgaaca cggaggtcag
    20041 cacgtgcgag cagcagttct gacgcagttc ggcgccccgc tcacagtgcg ggaggtgccc
    20101 gaccctgagg cgggaggcgg tgaagtactg gtcgaggtac tcgccgcctg tgtgcccccc
    20161 tacgcggtgg aggtcttcag cggcgagcgg agataccccc tcgtccctcc cgtcgtgccc
    20221 ggtcccggcg gcgtggggcg ggtcgtccac gtcggaccgg acgccacccg gctgcgcgcc
    20281 ggcgacctgg tgtggtgcga ctcgacggtg cggtcacggg atgacgccct gacgcccgac
    20341 atcacgttgc aaggctggag ttcccgaggc gacggcggcg cgaggctcgc ccggcacctg
    20401 cgcgacgggg cgttcgccga gttgctgcgg gtccccacgg agaacgtctt tccccttccc
    20461 gcggcggctg agcaggaccc ggcccggtgg gccgcgctct gcgtatatgc catctcctac
    20521 ggcgggctgc tggccggtga gctcgaggcc ggtgagacgc tgctcgtcag cggagccacc
    20581 ggaaacctcg gcagcagcgc ggtggcgctc gcgctcgcga tgggggcggg ccgggtcgtc
    20641 gcgccgggtc ggaacccggc cgcgctcggc ctcctcgccg accggttcgg cccgcgcgta
    20701 cgcccggtcc ggctgaccgg ggacgaggcc gccgaccgcg cggcgatgac cgaagcggcc
    20761 gacggcccga tcgacatggt gctcgacctg ctcccgccga gcgcacccag ttcgacggcg
    20821 cgcgcggcag ccatgaccgt gcgcgagtac ggccgtgtcg tcctcatggg cggcgtcggc
    20881 atgctcggcg gcgacgacct cgcgctcccg tatccgtgga tcatgcggaa ctcgatcacc
    20941 gtgcgcgggc agtggatgta cccgcgcgcg gcgaacgtcg gcatcatccg gcttctcacc
    21001 tcgggtgcgc tggacctcgc ccctgaacgg gtccg
//
