LOCUS       NZ_CP017157            21050 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces lydicus strain 103 chromosome, complete genome.
ACCESSION   NZ_CP017157
VERSION     NZ_CP017157.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lydicus
  ORGANISM  Streptomyces lydicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Complete genome sequencing of Streptomyces lydicus 103 and metabolic
            pathways analysis of antibiotic biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2016) Key Laboratory of Systems Bioengineering
            (Ministry of Education), Tianjin University, Tianjin 300072, PR
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001729485.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:23:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,288
            CDSs (total)                      :: 7,195
            Genes (coding)                    :: 7,061
            CDSs (with protein)               :: 7,061
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 47 of 134
            Pseudo Genes (incomplete)         :: 104 of 134
            Pseudo Genes (internal stop)      :: 11 of 134
            Pseudo Genes (multiple problems)  :: 26 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:52:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3919236
            Orig. end                         :: 3940286
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017157.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA is available from Prof. Ying-Jin Yuan.
            Annotation modified by submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21050
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="13"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21050
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21050
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11050](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11050
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            193..1176
                     /locus_tag="SL103_RS17005"
                     /old_locus_tag="SL103_17005"
     CDS             193..1176
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020124860.1"
                     /locus_tag="SL103_RS17005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17005"
                     /product="CehA/McbA family metallohydrolase"
                     /protein_id="WP_079146254.1"
                     /transl_table=11
                     /translation="MSFPSVRAVGRGAAWYRGDCHVHSVRSRGGELTPEELALRARAAG
                     LDFLATTEHGSAAEPGAWGHLAADDFLIVLGEEVTTKTGHWLALGISPGQVVDGDHGVR
                     DGLIDHCLDQVHRVGGLCVAAHPHAPYPSGAFMYSFQGFDVVEVWNGLWTSDRPWNADN
                     EAALAEWGRSLAADLRTGAWRPAMGNSDTHLEGQIGIPHTVVFAEELSTEAILAGIRSG
                     RSWIAESAAVEVSFTAHVESRIAGVGERLATHGAQVEVRAAVRGVPAATVSFHTERGKA
                     HRVALPGDGTGVVQWHTTAEDSAFVRIEVRHPDGTVAALTNPIILT"
     misc_feature    complement(1648..1661)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.62"
                     /tool="antismash"
     gene            1846..2202
                     /locus_tag="SL103_RS37870"
     CDS             1846..2202
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS37870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164492824.1"
                     /transl_table=11
                     /translation="MTATDYRPYESPGIPSSPDGDRLCAEFMEALLSDEVTKSIQESGP
                     MAILAATDAIRQILAGPDSPVGHRLVALAAAIPAKGGEAGPIIAEYTARHAMDETQATL
                     MALRDYWGPPPAGA"
     misc_feature    2375..2388
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.55"
                     /tool="antismash"
     misc_feature    2384..2402
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.72"
                     /tool="antismash"
     misc_feature    2817..2830
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.32"
                     /tool="antismash"
     misc_feature    2819..2832
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.35"
                     /tool="antismash"
     gene            2952..5363
                     /locus_tag="SL103_RS17020"
                     /old_locus_tag="SL103_17020"
     CDS             2952..5363
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669517.1"
                     /locus_tag="SL103_RS17020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17020"
                     /product="SdrD B-like domain-containing protein"
                     /protein_id="WP_069573826.1"
                     /transl_table=11
                     /translation="MAATAGPAAASTADGTLTVEVLRDFFGTGVVNTTMDVPQRGMKVE
                     ISDPAGHHVTGVTDATGKVVVSQSTVLSGGRYRVDVSVPAPYSGYLRAAPASTVENHFD
                     SFTSFVDVSDGKNASVVTGVWDPADYALPDSRYFVPVHNGANGTDTRALVAFGTKTRGT
                     CPTNATCPDTLATQAQVGTTFGLAYDKYRTQLFQSAFARRYAPYGPQGGGAIYTVPVSG
                     SGAPKLFAQVPDAAVTRHDTANMIKDPGFTDAPGKESIGGLTLSEDGSTLYAVNLRTRS
                     LVSFDATGATASEPEATVPIPDPGCASPRDWRPFGLSVHNNTLYVGGVCSAESTQQRAD
                     LKAVVSTYDGKRFTKVLTHALTDKRGSVFGSGDKATHWNPWNTGLDTWDDRKAGNVFID
                     PQPELASLTFARDGSMILGFRDRFMDVLSWGGLDPRPGNDTAENAMSGGDITMVCATPT
                     GEYQWEGTGSCPNHATPANSGGQPADVVEYFPGDTYANAHQETALGSVAYIPQQQWVVS
                     TEFDPVADVATSGTGYHNIATGEGPGNNPNANGFQFVSREQGGFGKAGGLGDIAYAAAN
                     APIQIGNVVWFDGDHNGIQDPGHVLLPGATINLLDADGKQVATTKTDAAGEYYFGGVGA
                     AYRLTPGAKYTVQFDVCTADTSKVPGQPPASELRFTLPRAGANRAHDSNVTPPTTGRLC
                     NGYAPVTAPAKPGGVDHTIDAGVYIPKETPTPTPTPTPTPTSTSSSPPASTPPSPAPPG
                     NHPAPADEGTGSLAHTGMSGLPQMIALVGLLVGAGLVLAFMSRKRRSQKH"
     gene            5663..6352
                     /locus_tag="SL103_RS17025"
                     /old_locus_tag="SL103_17025"
     CDS             5663..6352
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567832.1"
                     /locus_tag="SL103_RS17025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17025"
                     /product="hypothetical protein"
                     /protein_id="WP_069573827.1"
                     /transl_table=11
                     /translation="MAAATVFLVAGGGSGPSGPRALTSDEANRLAIARFRNYEAHGRAV
                     TITVPGTAGGLIVTGSVDYRGKLGYGVVHGTGRGTSSDGLIEWTATSVFVHPMANAPAR
                     APASPPRSGWYRRPLQSTGSALDSSLAIALRLGSDRPDNSQLLPQNGAAWWGRDQVGGH
                     RVDVMTGPSSRDRPDTAGSVRYWIGSDGTMYRVRVSVASESQPVVIDFDTQKYAPVKPV
                     PGVRSAR"
     gene            complement(6360..7700)
                     /locus_tag="SL103_RS17030"
                     /old_locus_tag="SL103_17030"
     CDS             complement(6360..7700)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014053642.1"
                     /locus_tag="SL103_RS17030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17030"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_069569866.1"
                     /transl_table=11
                     /translation="MPRLALRAVAAVLGTLTLVVSCGGGDDGSGKGRRPAGAQVTIRVP
                     ADAPTISDGVSLARPGDLVLVAPGVYHESVKIDTARITLRGASRDKVVIDGRLQQPNGV
                     VVAAPGVAVQNLTVRNNTQNGVLVTGSAKAVAGLPGHSGGYDTGDEPVTLLKSFLVSYV
                     TATRNGLYGIYAFSAQNGVIEHSYASGGADSGIYVGQCKPCHIVVRDNIAELNAVGFEG
                     TNASGDMYVVGNRLVGNRVGLTTDSDHQEKLLPQQGAVIAGNLIAANQQKATPQQADGG
                     WGIGIGIDGGSDNTFVRNRIADNSNAGLVITATADIPPVGNQIVDNTFTVNGVDVGWTF
                     PTATRGRGNCLRGNDLRSTVPARLATTAPCPQPAGASSPAGSWTRTTAPGGIPFTEVAV
                     PGPQPQFPHATAAGATTVPAVPALPDTAGIPLPSKSLLAADARVRTS"
     misc_feature    complement(7689..7691)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7789..8946
                     /locus_tag="SL103_RS17035"
                     /old_locus_tag="SL103_17035"
     CDS             7789..8946
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669520.1"
                     /locus_tag="SL103_RS17035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17035"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_069569867.1"
                     /transl_table=11
                     /translation="MHRADHHPSRRRFLDVTGAVVAAGLTAGCTADAAQSDRHAATPAA
                     TPTPVAAMGRHQAGITLPQPAQPNLLAVVADLGATVAPGPLLAELGQAIRTLVAGTDPR
                     LLGLPPGDLTVTVGVGPRLVRTAGASLPGAADLPRFSRERIASPARGGDLLLQICASDA
                     LLLPVVAAALLDQAGDRIRERWRQSGRRGTNVSVGDGLTASRNPLGFVDGIVGPHTAAE
                     QERDLWLAGPPAVAGGTVAVLRRMELDLPRFAALSVAEQEAVFGRRRASGVPLSGGTAA
                     SGPELGAKTPDGRYLVPADAHVRRAHATAVGVGLMLRRSYSTDEPGPGLLFICFQNDLR
                     TFTATLSHMDVSDALLQFTTTTASATFLILPGFDRQRPLGSQLFG"
     misc_feature    8284..8286
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9012..9485
                     /locus_tag="SL103_RS17040"
                     /old_locus_tag="SL103_17040"
     CDS             9012..9485
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126394.1"
                     /locus_tag="SL103_RS17040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17040"
                     /product="hypothetical protein"
                     /protein_id="WP_069569868.1"
                     /transl_table=11
                     /translation="MGIQIEVVAGHPVNDEVERVLGLAEAVGEPVTVTFVWEGCAEAER
                     AVLVPAATLALWEHWAPSAYPASDPGDGNRAESERPELAHPAEFGAFTLFRRRVGGRTA
                     VARGGVVVAELLDPGEAHWLQTQARDVRQGFMDPKQKAAFEEFLARQPPVDEQ"
     gene            10001..11050
                     /locus_tag="SL103_RS17045"
                     /old_locus_tag="SL103_17045"
     CDS             10001..11050
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377851.1"
                     /locus_tag="SL103_RS17045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17045"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_069569869.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-61, bitscore:
                     206.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPATAPQAAASQTLARCRELVQPALVEAVERLHPWLAEMAAHAL
                     GWTRSEDGFRPGSQGKGVRQALAVLCAEAVGAPAECALAGAVTVELVHTFSLVHDDIMD
                     GDETRRQRESTWKAYGPGPAILAGDAMCALAAQILCDAPAAQVGAAVRHLADALHDMAR
                     GQADDLSFEFRSWAGPDAVRVHEYRSMAEHKTGALLGCATGLGAVLAGAPAATVAGLTR
                     AGRHLGVAFQAVDDLLGIWGDPQDTGKPVYSDLRRLKKTYPVLAALATDTGAAGQLIGI
                     LESGGTLDDAGARQAADLIEEAGGRHATRSEAQQHLNRAHDCLTALDLEPTACDEIRTL
                     LPFLIHRSA"
     misc_feature    complement(11134..11147)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.67"
                     /tool="antismash"
     gene            11222..14152
                     /locus_tag="SL103_RS17050"
                     /old_locus_tag="SL103_17050"
     CDS             11222..14152
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="SL103_RS17050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17050"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_069569870.1"
                     /transl_table=11
                     /translation="MPWVGTLEQGMRGLRIAALGPLRAWRGERQLDTGPAQQRAVLTSL
                     TLRCGQVASADELVRDVWGAEPPASAHVAVRNHVSRLRTVLESDSAAPQALVSVGGGYA
                     LRLPDGALDVTQAERLHARAQAARSQGDLEPAVRILAEAEALWDGTPLTGVPGPYAQRQ
                     RDRLVEYRLLLVEARLTLELQLGGHTRVVGELLALADEHPLREGLRALQMLALYRCGRQ
                     ADALAVYTAARRHLAAELGVDPGPELVRLHQRILEADPTLAPPSGAAAAPPAPGPAAGP
                     DRPTWVPPAQAPPDVPDFTGRREEIRQVRDALAGAVRTDATAPVICVIHGMGGVGKTAL
                     AVHAAHAVREQFPDGQLYVDLRGTGRERANPYEVQELFLRSLGVLAGNVPSGREARTAL
                     YRSRMAGRRLLLLLDNAADTEQVSALLPGTAGSAALITSRTALMCLPATTRTALEPFSE
                     PEALALLERMAGSGRCRQEQGTARDLVRACGLLPLAVRVVGARLVARPRWTLASLAERL
                     SDRSQRLGELEAGSLAVESVFHLGYSTLDDAEARAFRLLAIPEVPDLSPAAAAAALHCD
                     RREAEALLESLAHHGLLEPGEPGRYRYHDLLRLFARHRTLDTDPSATRQAVLSRVARFY
                     LTGTSSAMRAERPYSRLPDTADPDGMPGAAAFSDALHAQEWVLHELPAMLAVAGQILHH
                     PYRPVSAEDTRTLSGLLALLMPFTDFCLPWDAIHQLGHTLLRAADHHGERLATVFSCIA
                     AGVACAWSGHHEEAAALAARAHETLDPADRVLAPRVVYTMGVVASVKPDGLDRAIGHYR
                     SAHALACESGEPGMAAQCSVSLARAQLALDRPHQALEAARDALAHCPPGDNPVGIALAQ
                     RVLGDALAQLGRHEEAVTEYGTALAVCRAHGLHAQRAHTLLSLAAVLAAVGRPGQARTC
                     AAEGGAALAQLGDPTGEERARAFINRLAAAGPSDPRGQHTAAGSDH"
     gene            complement(14422..14865)
                     /locus_tag="SL103_RS17055"
                     /old_locus_tag="SL103_17055"
     CDS             complement(14422..14865)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS17055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SL103_17055"
                     /product="hypothetical protein"
                     /protein_id="WP_069569871.1"
                     /transl_table=11
                     /translation="MGLIKSTTTAQVAEAVRQSDPLARPVVTLGVGSGRHPFLYTLLSG
                     GIADGDSFFVTLTDRSVLFHEVASTGYRPGKLRYDVAHEEFRTRIGQVRRRPLWSTFRF
                     RFPGDAEAVPLNVRRAWRPEMDRFLDALRGDRLPGRAVEGRSS"
     gene            complement(14991..17828)
                     /locus_tag="SL103_RS17060"
                     /old_locus_tag="SL103_17060"
     CDS             complement(14991..17828)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="SL103_RS17060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17060"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_069569872.1"
                     /transl_table=11
                     /translation="MLIGRERELSALARLLGDPWTGGDSAVISGGWGCGKTALLRAALA
                     DIRQDPGTCVVSAVADPLERDLPFGVARRLFEHLAADDPSEQPFRDGTPDDARLLAPWT
                     QRPDEPASAVTAQDAEALGGLYRLCVRLAGARRLLIAVDDLQWADPHSLLWLRYLLRRA
                     DNLPLVVLATLGPGDARPHAAAVAAVEPLFQHRLTLDGLADDAVEALVTQVLGEAPEQP
                     FTVACREATGGNPLLLHAVLRGLRASGQRPRAELADRITGRVPADLGSAVLTRMQEVDP
                     HAVTTAQAVAVLGGAPGIDLITAVTGLPEPAVADAAHRLVGTGWMTGTEHGLSFVCDVL
                     PTAVAAVVLPSRHRDLHLRAARHLLAHEAPLLRVAAHLLLGPLGEPWVPEVLGRAATLA
                     AEQGDDAHAAALLRRALREELTAELRATLLATLGELELTSSLPVAVRNLERSLELSTAP
                     TQQTAIARKLAGALLALDRHPDALETLRRTSEAVRPTDPAQALRLEIDFIHTALSEATS
                     APAVMPRLMELDVSDAAGGPVQRPLAALLSLRAAMAGTSTSEVVALARLALSQGMAPED
                     DESIVYTGAVTSLGAAGETELALAYADAAVRAAHPGTSAFHYAHALTTRANIHCRRGRL
                     ADCQADAEAALGALDSIGVGPCNGLSTFAITTLAETLLRQGKLTDAEDLLVRGDLSGRL
                     NGNWINDYVLMVRGWLRCAQGRLEEGLADFLVCGERTGARGMPNPGFFPWRSEAALVYA
                     ALRQGETARTLAEEELRLARIWGVPEVTGVAVRALGVVIGGRKGLDLLGEAVRLLDGTP
                     ARVRYAQALADYGVLARKVGRLSEARAHLRRAVSVAHECTATSLADQALAELRAAGDRP
                     RTRTFHGVGALTPTERRVADLAGRGMTNREIAQRLFVGLRTVEVHLTNVYGKLAIDGRA
                     GLARALAHADADESP"
     misc_feature    18054..18068
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.07"
                     /tool="antismash"
     gene            18406..18840
                     /locus_tag="SL103_RS17065"
                     /old_locus_tag="SL103_17065"
     CDS             18406..18840
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007263366.1"
                     /locus_tag="SL103_RS17065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17065"
                     /product="DUF485 domain-containing protein"
                     /protein_id="WP_069569873.1"
                     /transl_table=11
                     /translation="MTTHASPPDSSAADAPGGTGTPPATDDPTAAVFRTAQQGRPFRQL
                     RRSQRVFAAVATTAVLSLYLLYVLLSSYAPGLMTGRVVGNLNVALFLGLAQFAATFLAA
                     WLYTRHANRRRDPLAEQIKDGIEQARIRAHSHLAAEGTEA"
     gene            18837..20465
                     /locus_tag="SL103_RS17070"
                     /old_locus_tag="SL103_17070"
     CDS             18837..20465
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573719.1"
                     /locus_tag="SL103_RS17070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_17070"
                     /product="cation acetate symporter"
                     /protein_id="WP_069569874.1"
                     /transl_table=11
                     /translation="MITQLRQTALAAPGADGGRWLTLGLFLVVVAATLGVTLWASRQTK
                     GTTDFYTGGRSFSGFQNGLALSGDYMSAASFLGVTGTIALFGYDGFLYSVGFLVAWILA
                     LVLVAEPLRNTGRFTMADVLAFRLRQRPVRTAAGISTIVVSVVYLLAQMVGAGSLVALL
                     LGVSGEAPKKWIILAVGILMILYVVVGGMKGTTWVQIVKAAMLMAGTLVLTVLLLSKFG
                     WNLSTLLGSAAEASGKGHAFLSPGLKYGAGPTTKLDFISLGVALVLGTAGLPHILVRFY
                     TVPTAKTARTSVNWAIGLIGGFYLMTLVLGFGAAALVGHSAIEAANPAGTTAAPMLAEA
                     LGGGPGSTLGGTLLAVTSAVAFATILAVVAGLTLTSSASFAHDLFAHAVRKGKAGEREE
                     IRTARFAAVGIGTVAVVLSMFADKLNTAALVALAFAVAASANLPTLLYSLFWKRFNTSG
                     ALCSIYGGLLTSVVLVLFSPVVSGTPASLVPGADFHWFPLENPGLVSIPIGFLAGWLGT
                     LASRETDPDKYAELEVRSLTGAGAH"
     misc_feature    complement(20759..20774)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.75"
                     /tool="antismash"
ORIGIN
        1 gcagatggag ttctccgccc atctgccgga caacctgccg ggcgacatac ggttgcgcaa
       61 catctccgtg acgaagaacg gcattcgggc gcagctgacc ggcaaggatg taccggtggg
      121 ctgagacgac cacgcgggcg cgggcgccgt cacgcgcctc gacaggtcta tgaggggaga
      181 gccttgtcga gcttgagctt cccgtcggta cgggcggtcg gacgcggggc ggcctggtac
      241 cgcggtgatt gccatgtcca ctccgtgcgc tcgcgcggcg gagaactcac ccccgaggag
      301 ttggcgctcc gagcccgcgc cgccgggctc gacttcctcg cgacgacaga gcacggatct
      361 gctgcggaac ccggtgcgtg ggggcatctg gctgccgatg acttcttgat cgttctcggt
      421 gaggaagtga ccacgaagac cgggcactgg ctcgcgctcg gcatcagccc cggccaggtc
      481 gtcgacggtg accatggcgt cagagacggg ctgatcgatc actgcctgga ccaggtccat
      541 cgagtggggg gcctgtgcgt ggcggcgcac ccgcacgcgc cctatccatc gggcgccttc
      601 atgtactcct tccagggctt tgacgtggtg gaggtgtgga acgggctgtg gacgtcggac
      661 cggccctgga atgctgacaa cgaggcggcc ctggccgaat gggggcggag cctggcagcc
      721 gacctccgga cgggtgcgtg gcggccggcg atgggcaaca gcgacacgca cttggaggga
      781 cagatcggca tccctcacac cgtggtcttc gccgaggagc tgagtacgga ggcgatcctg
      841 gccggaatcc gctcgggccg gagctggatc gccgagtcgg cggccgtgga ggtgtcgttc
      901 acggcccatg tggagagccg catcgccgga gtgggagaac gcctcgcaac ccatggtgcg
      961 caagtcgaag tgcgcgcagc agtaaggggt gtgccggcgg cgaccgtcag cttccacacc
     1021 gaacgaggga aggcgcaccg cgtcgccctt cccggtgacg gaacaggcgt ggtgcagtgg
     1081 cacacgacgg cggaggactc ggcgttcgtc cgcatcgagg tccgccatcc cgacgggacc
     1141 gtcgccgcac tcaccaaccc gatcatcctg acctgactga tcggttacgc gtgcggtgcg
     1201 cgggtccggc cacaccccgt cggaccacac accgggtgcg ccaccgacgc accgttcgcc
     1261 gactcccgcg ccggctcacg ctccggtccc cgctgctgta cccgctcctt ggcgccggcc
     1321 tccgccgacc tggtcagccg tcagttcaac gctgcgctgc ccgtgatcgg cgtcttgcgc
     1381 accgaagtga ggtacggcca ctatctggag gtgactgcca ccggcaccac cacagctggc
     1441 ctggaacgcg ccccggcggt catccgctgc aagaccgccg ggtaccgcgc ggagcacccc
     1501 cgccatcttc ctcaccccgg ccgcgctatc cggcacaacc gcaccggcgg agctgccgtc
     1561 acacgctccc tcctcgccca tgaaccctga ccgcggtcgg aacgacgcgt cgagcggtgg
     1621 acagcgccac gacacctctg gagggtgttc atgggcatgc gacagggggc gcgggcgagg
     1681 gtggaccggt tccctgaccc gctcgtggtc cggcagcggc gtggtccggt gccggacagc
     1741 ctcgcacggc tggctgacgg cctcgccgac cacgcgtgcc ggcagaggcc ggcacggctg
     1801 accatgggac cgcccgggca ccccgctctg gacggggcac gggtcgtgac cgccaccgac
     1861 taccggccgt acgagtcacc ggggatcccc agctcgccgg acggcgaccg tctctgcgcg
     1921 gagttcatgg aggcgctgct cagcgacgag gtcaccaaga gcatccagga gagcgggccg
     1981 atggcgatac tggccgccac ggacgcgatc cggcagatcc tggccggtcc cgacagccct
     2041 gtggggcacc ggctggtcgc gctcgcggct gccattcccg ccaagggtgg cgaggccgga
     2101 ccgatcatcg ccgagtacac cgcgcggcac gctatggacg aaacccaggc caccttgatg
     2161 gcacttcgtg actactgggg cccaccgccc gctggcgcct gaggcacctg cccggccatc
     2221 accggacccg ccccgtcctg ggagcgtcca tcggaccggg cgaactccgg atgcggctca
     2281 cacctcggta gcggccctgt cgccctcgcc gttgaccgta cgggggaagt tccccggcac
     2341 gatgatcgaa gcttgcgcac ccctggcgcc gaccggcatc tgaattgcga tcaactctcg
     2401 ctcggtcgag agcgacacgt cgctgccgca tattctttcg agcgccattc tccgggaact
     2461 cggggattat ccgcggatcc tgatggatgt cagggttccg ctggtggcgg cgagacttca
     2521 acgcatagaa tatcgcgcgc tgctcgcgag ggtggccggt gaggtcggcg gtgggggcgg
     2581 ggacagcgtg attgagctgc aaatgcactc aatgcagggc gatatcgcct ggggttctga
     2641 acgcgcgttc gcttttcctg gcctgcggca cttacgactc gtcggtaata tcgccaagag
     2701 atcatcacga ggcggtccac gcgacagcag tgggcccttt ttcttttccg tggggtccgc
     2761 gaccggctgc cgctccggga gccacgaagt cgacctgcgg cgagaagcgg gcgcttcgtt
     2821 ttcaagacaa gagaagtgtg gagtgtgatg ccgtgaaccg agtcggcaga gactcgcgcc
     2881 ggtcggcccc ccagcttgcg gggccgctgg cgcgcatagg gttatccgtc ctgttagtgg
     2941 caggcggcac cgtggcggcg acggctggac cggccgccgc ttcgaccgcc gacggcacgc
     3001 tgacggttga ggtgctgcgg gacttcttcg gcaccggcgt agtcaacacg acgatggacg
     3061 tgccgcagcg gggcatgaag gtcgagatct ccgaccccgc cgggcaccac gtcaccggtg
     3121 tcacggatgc caccggaaag gtcgtggtgt cgcagtcgac ggtgctgagc ggcggccgat
     3181 accgcgtcga cgtcagcgtc ccggcgccgt acagcggcta tctgcgggcg gcgcccgcgt
     3241 cgacggtgga gaaccacttc gacagcttca cgtcgttcgt ggacgtgtcg gacggaaaga
     3301 acgcctcggt ggtgacgggg gtgtgggatc cggccgacta cgcgctgccg gactcgcggt
     3361 atttcgtgcc ggtccacaac ggcgccaacg gaaccgacac ccgggcactg gtggcgttcg
     3421 ggacgaagac ccgaggcacc tgtcccacga atgccacgtg cccggacacg ctggccacgc
     3481 aggcccaggt gggcacgacg ttcgggttgg cgtacgacaa gtaccggacc cagctgttcc
     3541 agagcgcgtt cgcccgccgg tacgccccgt acgggccgca gggcgggggc gcgatctaca
     3601 cggtgcccgt cagcggctcg ggtgcgccga agctgttcgc ccaggtgccg gacgccgcgg
     3661 tgacgcggca cgacaccgcc aacatgatca aggatcccgg gttcaccgac gcaccgggca
     3721 aggagagcat cggtggcctg accctgtcgg aggacggctc cacgctgtac gcggtgaacc
     3781 tgcggacccg cagcctggtg agcttcgacg cgaccggggc caccgcgtcg gagcccgagg
     3841 cgaccgtgcc gatcccggac ccggggtgcg cgagcccccg cgactggcgg ccgttcggtc
     3901 tctccgtcca caacaacacg ctgtacgtgg gcggcgtgtg cagcgcggag agcacgcagc
     3961 agcgcgcgga cctgaaagcc gtcgtctcca cctacgacgg caagcggttc accaaggtgc
     4021 tgacccacgc gctcaccgac aagcgcggca gcgtcttcgg ttccggcgac aaggccaccc
     4081 actggaaccc gtggaacacc ggcctggaca cgtgggacga ccggaaggcg ggcaacgtct
     4141 tcatcgatcc gcagccggag ctggcctccc tcaccttcgc ccgcgacggt tcgatgatcc
     4201 tgggtttccg cgaccggttc atggacgtgc tcagctgggg agggctggac ccccgcccgg
     4261 ggaacgacac ggcggaaaac gccatgtccg gtggcgacat caccatggtc tgcgccaccc
     4321 ccaccggtga ataccagtgg gaaggcaccg ggagttgccc caaccacgcc acccccgcca
     4381 acagcggcgg ccagcccgcc gacgtcgtcg aatacttccc gggcgacacc tacgccaacg
     4441 cgcaccagga gaccgcgctg gggtcggtgg cgtacatccc gcagcagcag tgggtcgtca
     4501 gcacggagtt cgacccggtc gccgacgtcg cgacctcagg gaccgggtac cacaacatcg
     4561 cgaccggtga gggtccgggc aacaacccga acgccaacgg gttccagttc gtcagccggg
     4621 aacaaggcgg cttcggcaag gccggtgggc tcggtgacat cgcgtacgcg gcggcgaacg
     4681 cgccgatcca gatcggcaac gtcgtgtggt tcgacggcga ccacaacggg atccaggacc
     4741 cggggcacgt gctgctgccg ggggcgacga tcaacctgct ggacgcggac ggcaaacagg
     4801 tcgccacgac caagaccgat gccgccggcg agtactactt cggtggcgtc ggcgccgcgt
     4861 accggctcac gccgggcgcg aaatacacgg tgcagttcga cgtgtgtacc gcggacacca
     4921 gcaaggtgcc cggccaaccc ccggcgagcg aactgcggtt cacgctcccg cgagccggtg
     4981 ccaatcgtgc gcacgactcc aatgtgaccc cgccgacgac cgggcggttg tgcaacggct
     5041 acgcgcccgt cacggcaccg gccaagccgg gcggggtcga tcacacgatc gacgccgggg
     5101 tctacatccc gaaggaaacg cctaccccga cgccgacacc tacaccgacc ccgacctcga
     5161 catcgagttc gccaccggcc tccacgccgc cgtcacccgc gccgcccggc aaccatccgg
     5221 ccccggccga tgagggcacg ggttcgctgg cgcacaccgg aatgtccggg ctgccacaga
     5281 tgatcgccct cgtcggtcta ctggtggggg cgggactggt cctcgcgttc atgagccgta
     5341 agcgccgctc ccagaaacac tgaacgaacc gaacaacagt gatctgcccg cccgcgatcc
     5401 ggaaggcgcg gtcgggcaga tcacgtctcg gccgacccac gagggccggc ctggatgtcg
     5461 tccgtcaccg gactgccgag tgccgccgtg accgcacggc ggccgagcgg tgcggtggtt
     5521 gagaggggga atcagcagag tgtcagcgtc gagccgcgtg cggagcgtga gaagccggca
     5581 agccgtaccg ggtcgtgcgg ccgaccggcg ccgatggctg cggccacgcc gggtggcggc
     5641 cctcggcaca gccaccgtcg cggtggccgc ggcgaccgtg ttcctggtcg ccggcggcgg
     5701 ttccggcccc agcggcccgc gcgcactgac gtcggatgag gcgaaccgcc tggcgatcgc
     5761 acggttccgt aactacgagg cgcacggccg cgcggtgacg atcaccgtgc ccggcaccgc
     5821 cggcggactg atcgtcaccg ggtccgtcga ctaccggggc aagctcggtt acggggtggt
     5881 gcacggaacc ggccgcggca cctccagcga cgggttgatc gagtggacgg ccacctcggt
     5941 gttcgtccac ccgatggcga acgccccggc gcgcgcaccc gcgtcgccgc cccgctcggg
     6001 ctggtaccga cgcccgctgc agtcgaccgg cagcgcgctg gacagttcgc tggcgatcgc
     6061 gctcaggctc ggcagcgacc ggccggacaa ctcccaactg ctgccgcaga acggcgccgc
     6121 ctggtggggg cgggaccagg tgggcggaca ccgggtggac gtcatgaccg ggccgtcctc
     6181 ccgtgaccgc cccgatactg cgggcagcgt gcgctactgg atcggctcgg acggcaccat
     6241 gtaccgggtc cgcgtcagcg tggcatccga gtcgcagccg gtggtcatcg atttcgacac
     6301 ccagaagtac gctccggtga agccggtacc cggagtccgc tcggcgcggt agcccctgtt
     6361 caggacgtcc gcacccgcgc gtccgcggcg agcagggact tcgacggcag cgggatgcct
     6421 gccgtgtccg gtagggccgg aacggccggg acggtggtgg cgcccgcagc agtggcgtgg
     6481 gggaactgcg gctgcggacc cggcacggcg acctcggtga acgggatgcc gccgggtgcc
     6541 gtcgtcctcg tccaactgcc ggccggcgag gacgccccgg ccggctgcgg gcagggcgcg
     6601 gtggtcgcga gccgggcggg caccgtgctt cgcagatcgt tgccgcgcag gcagttgccc
     6661 cgtccccgcg tggcggtggg gaaagtccag ccgacgtcca cgccgttgac ggtgaacgtg
     6721 ttgtccacga tctggttgcc gaccggagga atgtcggcgg tcgcggtgat caccagcccg
     6781 gcgttgctgt tgtcggcgat gcggttgcgc acgaacgtgt tgtcgctgcc gccgtcgatg
     6841 ccgattccga tgccccaccc gccgtcggcc tgctgtgggg tggccttctg ctggttggcg
     6901 gcgatcaggt tgcccgcgat gacggcgccc tgctggggga gcagcttctc ctggtggtcg
     6961 gagtcggtgg tgaggccgac ccggttgccg accaggcggt tgccgaccac gtacatgtct
     7021 ccgctggcgt tggtgccttc gaaaccgacc gcgttgagtt cggcgatgtt gtcccgcacc
     7081 acgatgtgac agggcttgca ctgtccgacg tagattcccg agtccgcccc gcccgaggcg
     7141 taggaatgct cgatgacacc gttctgcgcg gagaacgcgt agatgccgta caggccgttg
     7201 cgggtcgcgg tcacgtagga gaccaggaaa gacttcagca aggtgaccgg ctcgtcgccg
     7261 gtgtcgtagc cgccggagtg ccccggcagc ccggcgaccg ctttcgccga accggtgacc
     7321 aggaccccgt tctgcgtgtt gttccgcacg gtcaggttct gcacggccac cccgggcgcc
     7381 gcgacgacga caccgttcgg ctgctgcagt cgcccgtcga tgacgacctt gtcccgggac
     7441 gcaccgcgaa gagtgatgcg tgccgtgtcg atcttcaccg actcgtggta cacgcccggc
     7501 gcgaccagta ccaggtcccc gggccgcgcc aacgacaccc cgtccgagat cgtgggggca
     7561 tcggcgggta ctcggatcgt cacctgcgca ccggccggtc gccggccttt gcccgacccg
     7621 tcatcgccgc cgccgcagct gaccacaagc gtcagcgtgc ccagtaccgc cgccaccgcg
     7681 cgaagagcta atcgaggcat gatcccagtc tggcatgacg cccaagtcca cgccagaatc
     7741 gcgaggttga ccggcgggtg cgatgcgggg tgtggcacgc tgcacaccat gcatcgagcc
     7801 gatcaccatc cgtcgcgccg caggttcctc gatgtcaccg gcgcggtggt ggccgccggt
     7861 ctgacggccg ggtgcacggc ggacgccgcc cagtcggacc ggcacgccgc aaccccggcg
     7921 gccacgccca cgccggtagc ggcgatgggc cgccatcagg cgggcatcac gcttccccag
     7981 ccggcccagc ccaacttgct ggccgtggtg gccgacctcg gtgccaccgt ggctcccggc
     8041 cccttgctcg cagaactcgg ccaggccatc cgcacactcg tcgcgggtac cgacccgcgg
     8101 ctgctgggcc tgccgccggg cgacctcacc gtgaccgtcg gcgtgggccc ccggctggtg
     8161 cgcacggccg gtgcctcgct gcccggcgcg gccgacctcc cgcggttctc ccgtgagcgg
     8221 atcgcctcac cggcacgcgg cggtgacctg ctgctacaga tctgcgccag cgacgcgctg
     8281 ctgttaccgg tcgtcgccgc cgcgctcctg gaccaggccg gcgaccgtat ccgcgaacgc
     8341 tggcggcagt ccggacgccg cggtacgaac gtgtccgtcg gcgacggcct cacggcttca
     8401 cgcaacccgc tcggcttcgt cgacggcatc gtgggcccgc acacggccgc cgaacaagaa
     8461 cgcgatctgt ggctggccgg gcccccggcg gtcgccggcg gcaccgttgc cgtgctgcgg
     8521 cgcatggaac tcgacctgcc gaggttcgcc gccctgtccg tagccgagca ggaagcggtc
     8581 ttcgggcgac gccgggccag cggcgtcccg ctctccggcg gtaccgccgc ctccggcccg
     8641 gaactcggcg ccaagacacc ggacggccgc tatctcgttc ccgcggacgc ccacgtgcgc
     8701 agggcgcacg ccaccgcggt cggggtcggg ctcatgctcc gccgctccta cagcaccgac
     8761 gagcccggcc ccggcctgct cttcatctgc ttccagaacg atctgcggac cttcaccgcc
     8821 accctcagcc acatggatgt ctccgacgcg ctcctgcaat tcaccaccac caccgccagc
     8881 gcgacattcc tgatcctccc cggcttcgac cggcaacgcc cgctcggttc ccagctgttc
     8941 ggctgatcac gcggtggccg ccgggcgcag cgggcctgga gtgtcagagg cggccagtag
     9001 cctcgggcgc catgggaatt cagatagagg tggtggcggg tcacccggtc aacgatgagg
     9061 tggagcgggt gctcggcctg gccgaggcgg tcggcgagcc cgtcaccgtc acgttcgtgt
     9121 gggaggggtg tgcagaggcg gagcgcgccg tgctggtgcc cgcggccacg ctggcgctct
     9181 gggagcattg ggccccctcc gcctacccgg cgagtgaccc cggggacggg aaccgggctg
     9241 aatcggaacg gccggaactg gctcacccgg cggaattcgg agcgttcacg ctctttcgcc
     9301 gtcgcgtggg agggcgcacg gcggtcgctc gcggaggcgt agtggtcgcc gagctcctgg
     9361 accccggcga ggcgcactgg ctccagacgc aggcccgcga tgtccgccaa ggattcatgg
     9421 atccgaagca gaaggcggcg ttcgaggagt tcctcgcccg tcagccaccc gtcgatgagc
     9481 agtgatgcgc cgctcgtgct ccttcggccg cggcttccgg catcgggcca ccggttgtca
     9541 tccggcggcg cgggtttccc cgtaacggca cggcagcccc gtggcaccgg ccgcgatgat
     9601 ccgggcgtgc tcccggagcc ggccgccggc cctcctgtga gatgccgtcc aaatccttcg
     9661 gtgccgcccg tcatccctcg cggcttgttc gccacctaac ttggctgaac aggggctgtg
     9721 ttcgccgccc agcgcggcca ccgccgggcc cggctcggca caggtaccgc cggccacccc
     9781 cggtggctcc accggcggaa ccgcatcgcg gaccaggcgc gacccgcagg acacgcccct
     9841 gccgtgccac gaccgtgtcc ggtgtacgcg gtcgggcatc ccgaccgcgc tcgggatgcc
     9901 cgaccgggct gccctctgtc cgcggaccgc cccgtcgtgg ccgccggacg gagacccgga
     9961 cgtgcacagg aatcccccac ccgaaaggac actcccgatc atgacgcctg ctacagcgcc
    10021 ccaggccgcc gcgtcgcaga ccctggcccg ctgccgcgag ttggtgcaac cggcgctcgt
    10081 ggaggccgtc gagcgcctcc acccgtggct ggcagagatg gcagcccacg cgctcggatg
    10141 gaccaggtcg gaggacggct tccgccccgg ctcccagggc aagggggtgc gccaggcact
    10201 cgcggtgctc tgcgccgagg ccgttggggc gcccgcggag tgcgccctcg ccggtgcggt
    10261 caccgtggag ttggtgcaca ccttctccct cgtgcacgac gacatcatgg acggcgatga
    10321 gacccgtcgg cagcgcgaga gcacctggaa ggcatacggt cccggacccg cgatcctggc
    10381 cggcgacgcg atgtgcgccc tcgctgccca gatcctctgc gacgccccgg cggcacaagt
    10441 cggagcagca gtacggcacc tcgccgacgc cttgcacgac atggcgcggg gtcaggccga
    10501 cgacctctcc ttcgagttcc gttcatgggc gggcccggac gcggtccggg tgcacgagta
    10561 ccggtcgatg gccgagcaca agacgggtgc actgctcggg tgtgccaccg gtctgggcgc
    10621 cgtgctcgcc ggcgcaccgg ccgcgaccgt cgcaggtctt acccgagccg gccggcatct
    10681 cggggtggcc ttccaagcag ttgacgacct tctgggtatc tggggagacc cgcaggacac
    10741 cggcaaaccg gtatacagcg atctgcgacg gctgaagaag acctaccctg tcctggcggc
    10801 gctggccacc gacaccgggg ccgcggggca gctcataggg attctcgaat cgggcgggac
    10861 actggacgac gccggcgccc ggcaggccgc cgatctcatc gaggaggcgg gcgggcgcca
    10921 cgccacccgc agcgaagccc aacagcacct caacagggcc cacgactgcc tgacagcgct
    10981 cgacctggag ccgacggcat gcgacgagat ccgcaccctg ctgcctttcc tcatccatcg
    11041 cagcgcgtga cggtgacgcc gtgcgcggtg gtggcgtgcg accgccgccc cgtatcgacc
    11101 agtggacact ccggtcgtcg tacgcgcgtc cggtgataat gactacgggg tgtcacttcc
    11161 cggcaagtgc ccgccccctc ggttctcggc caatgaacca tgacaggttg agcgatgact
    11221 gatgccgtgg gtcggaacgt tggagcaggg catgcggggg ctgcggattg cggcgctggg
    11281 tccgctgagg gcatggcgcg gtgagcggca actggacacc ggaccggcac agcagcgcgc
    11341 ggtgctcacc tcactgacgt tgcggtgcgg gcaggtcgcc tccgcggacg agctggtgcg
    11401 ggacgtctgg ggagcggagc cgccggccag cgcgcacgtc gcggtacgca accacgtctc
    11461 acgcctgcgc accgtgctgg agagcgactc cgccgcaccc caggcgctgg tctccgtcgg
    11521 cggcggctat gcgctgcgcc tgccggacgg ggcgctggac gtcacccagg ccgaacggct
    11581 ccatgcccgg gcgcaggcgg cccggagcca gggggatctg gagccggccg tccgcatcct
    11641 tgccgaggcc gaggcgctgt gggacggcac tccgctgacg ggggtgcccg gcccgtacgc
    11701 ccagaggcag cgggaccgcc tcgtggagta ccgtctcctc ctcgtcgagg cgcggctgac
    11761 cctggaactc cagctcggcg gacatacccg ggtcgtcggg gaactgctcg cgctggccga
    11821 cgaacatccg ctgcgcgagg ggctgcgtgc gttgcagatg ctggcgctgt accgctgcgg
    11881 ccggcaggcc gacgcgctgg ccgtgtacac cgcggccaga cggcacctcg ccgcggagct
    11941 gggcgtcgat ccgggccctg agctggtacg tctgcaccag cgcatcctgg aagcggatcc
    12001 gacgctggca ccgccgtcgg gcgcggcggc cgcgcccccg gcgcccggcc cggccgccgg
    12061 accggaccgg ccgacctggg tgccgccggc gcaggccccg cccgacgtcc ccgacttcac
    12121 cggacgcagg gaggagatcc ggcaggtccg cgacgcgctg gccggtgccg tgcggacgga
    12181 cgcgaccgct ccggtgatct gcgtgatcca cggcatggga ggtgtgggga agaccgcact
    12241 ggccgtgcac gcggcgcacg ccgtgcggga gcagttcccc gacggccagc tctatgtcga
    12301 cctgcgcggg accggacggg agcgcgcgaa tccttatgag gtgcaggagt tgttcctgcg
    12361 ctccttgggg gtcctggccg gcaatgtgcc cagtgggcgg gaggcgcgta ccgcgctcta
    12421 ccgttcgcgg atggccggcc gccggctgct gctcctgctg gacaacgccg ccgacaccga
    12481 gcaggtgagc gccctgctgc cgggtaccgc cggaagcgcc gcgctgatca ccagccgtac
    12541 ggcgctgatg tgcctcccgg cgaccacccg caccgcgctc gaaccgttca gcgagccgga
    12601 ggccctcgcc ctcctggagc ggatggccgg cagtgggcgg tgccgtcagg agcaggggac
    12661 ggcccgcgac ctggtgcggg cgtgcggcct gctcccgctg gccgtccgcg tcgtcggcgc
    12721 ccgcctggtg gcccgtccgc gctggacgct cgcgtcgctg gccgagcggc tcagtgatcg
    12781 ctctcagcgg ctgggtgagt tggaggccgg cagcctggcc gtcgaatcgg tcttccacct
    12841 cggttactcg acgctggacg acgcggaggc gcgcgccttc cggctgctgg ccatccccga
    12901 ggtgcccgac ctctccccgg ccgccgcggc ggcggcgctg cactgcgacc ggcgggaggc
    12961 cgaggcgctc ctggagtccc tggcccacca cggcctgctg gaacccgggg aacccggccg
    13021 gtaccgctac cacgatctgc tgcggctgtt cgcccgccac aggaccctgg acaccgaccc
    13081 ctccgccacc cggcaggcgg tcctgagccg ggtcgcccgc ttctacctca ccgggacgag
    13141 cagcgccatg cgcgccgagc ggccctacag ccggctgccc gacaccgccg atccggacgg
    13201 catgccgggc gccgcggcct tttccgacgc gctccacgcg caggaatggg tgttgcacga
    13261 gctccccgcg atgctggccg tcgccggcca gatcctccac cacccctatc gcccggtgag
    13321 cgcggaggac acccgcaccc tgtcgggtct gctggcgctg ctcatgccgt tcaccgactt
    13381 ctgcctgccg tgggatgcca tacatcagct gggccatacg ctgctgcgcg ccgccgacca
    13441 ccacggggag cggctcgcga ccgtcttcag ctgtatcgcg gcgggcgtcg cctgcgcatg
    13501 gagcggacac cacgaggagg cggccgcgct ggccgcccgc gcccacgaga cgctcgaccc
    13561 cgcggaccgg gtactggccc cccgcgtcgt gtacaccatg ggtgtggtcg ccagtgtgaa
    13621 gccggacggc ctggacaggg ccatcggcca ctaccggagc gcgcacgccc tggcgtgcga
    13681 gagcggtgag ccaggtatgg ccgcccagtg ctccgtcagc ctcgcccgcg cccagctcgc
    13741 gctcgaccgg ccgcaccagg cgctggaagc cgcccgggac gcccttgccc actgcccgcc
    13801 cggggacaat ccggtgggca tcgccctggc tcagcgcgtg ttgggcgacg cactggcgca
    13861 actcggccgg cacgaggaag cggtgacgga gtacggcacg gcgctcgccg tctgccgggc
    13921 gcacggactg cacgcacagc gcgcccatac gctgctgtcc ctcgccgcgg tgctggccgc
    13981 cgtcggccgg ccgggtcagg cccgtacgtg cgcggcggag ggcggggccg cgctggctca
    14041 gctcggcgat ccgacgggcg aggaacgggc gcgcgccttc atcaaccgcc tcgccgcggc
    14101 cggtccgtca gacccacgag ggcaacacac ggcagccggg agcgaccact gacgttccgt
    14161 ccggcgcggc ggcccggtgc acgggggccg cgacggacca gttcacctcg acggtctcgg
    14221 gcagccgggt tcgtgcccgg cagtgccacc cctgcacggc ctcgtccggc ggcgggagcg
    14281 gcggtggtgc cgtgctcggt ggggggctcg gcgtcggggt gtcgccgggg ccgccggtcg
    14341 gaccgcagcc gttgaccacg gccagggcca gggccagggg tatccatcgg ctgagaggca
    14401 gccgggggag gggacgtgag ttcacgacga gcgcccctcg accgctcggc cggggagccg
    14461 gtccccgcgc agcgcgtcga ggaaccggtc catctccggt cgccaggcac gccggacgtt
    14521 gagcgggaca gcctcggcgt ccccggggaa ccgaaaccgg aaggtactcc acagggggcg
    14581 ccggcggacc tggccgatcc gcgtgcggaa ctcctcgtgc gcgacgtcgt accgcagctt
    14641 ccccggccgg tatcccgtcg acgccacctc gtggaacagc acggagcgat cggtgagggt
    14701 gacgaagaaa ctgtcgccgt cggcgatacc gccggacagc agtgtgtaca ggaacggatg
    14761 gcgtcccgag cccacgccca gggtcaccac cggacgggcg agcgggtcgg actgccggac
    14821 ggcctcggcg acttgggccg tggtggtgga tttgatgagc cccatgggtg tctcctcggt
    14881 aggggtggac gtgacggcgg gggagttgat gaaggtacga accgggtgcg gcggcgtcgc
    14941 ggtcggcacc caggacattg cgcgggctgc gggccccagc tgatcggtcg tcacggcgac
    15001 tcatccgcgt cagcgtgggc cagtgcgcgg gccagtcccg cgcggccgtc gatggcgagc
    15061 ttcccgtaga cgttggtcag gtgcacttcc acggtgcgca gaccgacgaa gaggcgctgg
    15121 gcgatctcgc ggttggtcat gccccggccg gcgaggtccg ccacccgccg ctcggtgggg
    15181 gtcagcgctc ccacaccgtg gaacgtccgg gtgcgcggcc ggtcaccggc ggcacgcagc
    15241 tccgcgagcg cctgatcggc cagcgacgtc gcggtgcact cgtgggcgac actcaccgcc
    15301 cgccgcaggt gcgcacgggc ctcggacagc cggccgacct tgcgggcgag gacaccgtag
    15361 tcggccagcg cctgggcgta ccgcacccgc gcgggggtgc cgtcgaggag ccgtacggcc
    15421 tcgccgagca gatcgagtcc cttccgcccg ccgatcacca ctcccagggc gcgcacggcc
    15481 acaccggtca cctcgggcac accccagatg cgggcgagcc gcagctcctc ctccgccagt
    15541 gtcctggccg tctcgccctg ccgcagggcc gcgtacacca acgcggcctc cgaacgccag
    15601 ggaaagaaac cggggttggg catcccgcgg gcgccggtcc gctcaccgca gaccaggaag
    15661 tcggccagcc cttcctccaa ccgcccctgg gcgcagcgca accagccacg caccatcagt
    15721 acgtagtcat tgatccagtt gccgttcagc cggccgctca gatcgccgcg taccagcagg
    15781 tcctcggcgt cggtgagctt gccctgccgg agcagcgttt ccgccagcgt cgtgatcgcg
    15841 aacgtgctga ggccgttgca cgggccgacg ccgatgctgt cgagcgcccc cagcgcggcc
    15901 tccgcgtcgg cctggcagtc cgcgagacgg ccgcgccggc agtggatgtt agcccgggtg
    15961 gtgagggcgt gggcgtagtg gaaggccgag gtcccggggt gcgccgcccg caccgccgcg
    16021 tcggcgtacg ccagcgccaa ctccgtctct ccggcggccc ccagggaggt caccgcgccg
    16081 gtgtagacga tggactcgtc gtcctccggg gccatgccct ggctcagcgc cagccgggcc
    16141 agggccacca cttcgcttgt tgaggtaccc gccatggccg cgcgcaggct caacagggcg
    16201 gccaggggcc gctgcacagg gccgccggcc gcgtcggaga cgtccagctc catcagccgt
    16261 ggcatcacgg ccggggccga ggtcgcctcg ctcagggcgg tgtgaatgaa gtcgatctcc
    16321 agccgcaggg cctgggcggg gtccgtcggt cggaccgcct cgctggtgcg tcgcaatgtc
    16381 tccagcgcgt cggggtgccg gtcgagagcc aggagcgcgc cggccagctt gcgggcgatg
    16441 gcggtctgct gtgtcggggc cgtggacagt tccaggctgc gctccagatt gcggacggcg
    16501 accgggaggc tggaggtgag ttccagttcc cccagcgtcg ccagcagggt ggcccgcagt
    16561 tccgcggtga gctcctcgcg cagggcgcgg cgcagcaggg cggcggcgtg cgcgtcgtcg
    16621 ccctgctccg cggccagcgt cgccgcccgg ccgagcacct ccggcaccca cggctcgccc
    16681 aggggaccga gcagcagatg agctgccacc cgcagcagcg gagcctcgtg ggccagcagg
    16741 tgccgggccg cccggaggtg gaggtccctg tgccggctcg gcagcaccac cgcggcgacc
    16801 gccgtcggca gtacgtcgca gacgaaggac aggccgtgct ccgtcccggt catccagccc
    16861 gtgcccacca gccggtgcgc ggcgtccgcg acggccggct ccggcaggcc ggtgaccgcc
    16921 gtgatcaggt cgatgcccgg cgcgcccccg agcaccgcga cggcctgggc cgtggtcacg
    16981 gcgtgcggat cgacctcctg catccgggtg agcacggccg agcccaggtc ggccgggaca
    17041 cggccggtga tccggtccgc cagctccgcc cgggggcgct gcccggaagc ccgtagcccg
    17101 cgcagcacgg cgtgcagcag aagggggttg ccgccggtgg cctcccggca ggcgacggtg
    17161 aacggctgct caggggcctc acccaggacc tgggtcacca gcgcctcgac ggcgtcgtcg
    17221 gcgaggccgt cgagcgtcag ccggtgctgg aacagcggct cgacggcggc cacggcagca
    17281 gcgtgcggac gggcgtcccc cggaccgagc gtggcgagca cgaccagcgg caggttgtcg
    17341 gccctgcgca gcaggtaccg cagccagagg agggagtgcg gatcggccca ctgcagatcg
    17401 tcgacggcga tcaacagcct tctcgcaccc gcgagccgga cgcacagccg gtacaggccg
    17461 ccgagggcct ccgcgtcctg cgcggtcacc gcggacgccg gttcgtccgg ccgctgcgtc
    17521 cagggggcca gcagccgggc gtcgtccgga gtcccgtcgc ggaacggctg ctccgacggg
    17581 tcgtccgcgg ccaggtgctc gaagagccgg cgggccacgc cgaagggcag gtcgcgctcc
    17641 agcgggtccg cgaccgccga gacgacgcag gtcccggggt cctggcggat gtccgccagg
    17701 gcggcccgca gcagtgcggt cttcccgcac ccccaacccc cgctgatgac agcggagtca
    17761 ccgccggtcc aggggtcccc gagcagccgg gcgagcgcgc tcagctcacg ttcccgcccg
    17821 atcagcaccg gaccgcgccc cgttccgtag ggggagtggt cgctgcgggg ttggtcggca
    17881 tgtcacacca cgactgtctg gagggcggcc cccgtccgac gacgggggac acgcggtctt
    17941 acctggctgt ggagcggccg gcccaccggc ggcatgaagg tgacggggag cccgcatgcg
    18001 ccggggccgg cagctctgcc cagaagggtg gcgtcggcct gtaaggaatc ggcaattttc
    18061 cggcaagggg ccggcacggc gagcaacgga ccgtggccgc gagatctttc ggtgcgttgc
    18121 cccgtaccgc ggtcccttaa tccttcggta cggcccgtca tccatcgtgg ccggtcccgc
    18181 cccacacttt ggctgaacaa gggtcatgcg accggatgcc gtgcggcacc gcgcggctgt
    18241 caggagccgg ctcacgccgt cccgtactcc gcgccgaccc gagtcctcct gccgctcatc
    18301 ggccggcagg gagcccgttc accgtcgccg tgaaccggtg agcaccagcg ccccgcggcc
    18361 ggtccggctg ccgggccact ccgagcccca ccactggaaa ggcccatgac cacgcacgcc
    18421 tcccctcccg acagctccgc ggccgacgcg cccggcggca cgggaacccc gcccgccacg
    18481 gacgacccca ccgccgcggt gttccggaca gcacagcagg gccggccgtt ccgccagctc
    18541 cggcgctcac agcgggtgtt cgccgcagtg gcgacgaccg cggtgctcag cctgtatctg
    18601 ctgtacgtcc tgctgtccag ctacgcgccc ggcctcatga ccggcagggt cgtcggcaat
    18661 ctgaacgtcg cgctcttcct cggactcgcc cagttcgccg cgaccttcct cgccgcgtgg
    18721 ctctacaccc ggcatgcgaa ccgccggcgg gacccgctcg cggaacagat caaggacggc
    18781 atcgagcagg cccgcatccg tgcgcacagc cacctcgcgg cggaggggac cgaggcatga
    18841 tcactcaact tcggcagacg gccctggccg cccccggtgc ggacggcggc cgttggctga
    18901 cgctcggcct gttcctcgtc gtggtggcgg ccacgctggg cgtcaccctg tgggcgagcc
    18961 ggcagacgaa gggcaccacg gacttctaca ccggcggccg ctccttctca gggttccaga
    19021 acggcctggc cctctccggc gactacatgt ccgccgcctc gttcctgggt gtcaccggca
    19081 ccatcgcgct cttcgggtac gacgggttcc tgtactccgt cggcttcctc gtcgcctgga
    19141 tcctggcgct ggtcctggtg gccgaaccgc tgcgcaacac gggccggttc accatggccg
    19201 acgtcctcgc gttccggctg cgtcagcggc cggtgcgtac cgccgcgggc atctcgacca
    19261 tcgtggtctc cgtggtctac ctcctcgccc agatggtcgg cgcgggttcc ctggtggccc
    19321 tgctgctcgg cgtctccggc gaagcgccca agaagtggat catcctggcc gtcggcatcc
    19381 tgatgatcct ctacgtcgtc gtcggcggca tgaagggcac cacctgggtg cagatcgtca
    19441 aggccgcgat gctgatggcc ggaacgctgg tgctgaccgt tctgctgctg agcaagttcg
    19501 ggtggaacct ctccacgctc ctcggctcgg cggccgaggc cagcggcaag ggccatgcct
    19561 tcctctcgcc cggcctgaag tacggcgccg gcccgaccac caagctggac ttcatcagcc
    19621 tcggggtcgc gctggtcctg ggcaccgccg gcctgccgca catcctggtc cgcttctaca
    19681 cggtgccgac cgccaaaacc gcccggacct cggtgaactg ggcgatcggg ctcatcggcg
    19741 gcttctacct gatgacgctc gtgctgggct tcggcgcggc ggccctggtg gggcactccg
    19801 cgatcgaggc cgccaacccg gcgggcacca cggccgcccc gatgctggcc gaagcgctcg
    19861 gcggcggccc cggatcaacc ctgggcggca cgctgctcgc ggtgacctcc gccgttgcct
    19921 tcgccaccat cctcgcggtg gtggccggcc tcaccctcac ctcgtccgcc tccttcgccc
    19981 acgacctgtt cgcccacgcc gtgcgcaagg ggaaggccgg tgagcgcgag gagatcagga
    20041 cggcgcggtt cgccgcggtc gggatcggca cggtggccgt cgtactcagc atgttcgccg
    20101 acaagctcaa caccgcggcg ctggtggccc tggccttcgc cgtcgccgcc tccgccaatc
    20161 tgccgacgct cctgtacagc ctgttctgga agcggttcaa cacctccggc gcgttgtgca
    20221 gcatctacgg cggcctgctg acctcggtgg tgctggtgct cttctccccg gtcgtctccg
    20281 gcaccccggc gtccctggtg cccggtgcgg acttccactg gttcccgctg gagaaccccg
    20341 gcctggtctc catcccgatc ggcttcctgg ccggctggct gggcaccctc gcctcccgcg
    20401 agaccgaccc ggacaagtac gcggagctgg aagtccgttc cctcaccggt gccggcgcgc
    20461 actgacccgc agcgctgcga cgccgacgcc accgcagcgc acccctcgct cccacacccg
    20521 acgaacgact ccaaggaaca gcacgtcgtg aacaacgaaa gcctggcgaa cctcctccac
    20581 gaggaacggc ggttcgcccc gccggccgcc ctggcggcgg ccgccaacgt caccgccgac
    20641 gcctacgaga aggccaccgc cgaccggatc ggcttctggg cggagcaggc ccgccgtctc
    20701 agctgggcgg tgccgccgac cgagacgctg gactggtccg acccgccctt cgcctcctgg
    20761 ttcgccgacg gcgagctcaa tgtcgcgtac aactgcgtgg accggcatgt ggagaacggt
    20821 ctgggtgacc gggtcgccct ccacttcgag ggcgagccgg gcgacagccg cacgatcacc
    20881 tacgcggagc tgcagcgcga ggtcgccaag gccgccaacg cgctggtgga actcggcgtg
    20941 gcggccggcg tccgggtcgc gatctacctg ccgatgatcc ccgaagcggt catcgccatg
    21001 ctggcctgcg cgcgcctggg cgcaccgcac tccgtcatct tcgggggctt
//
