LOCUS       NZ_CP017157            22613 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces lydicus strain 103 chromosome, complete genome.
ACCESSION   NZ_CP017157
VERSION     NZ_CP017157.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lydicus
  ORGANISM  Streptomyces lydicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Complete genome sequencing of Streptomyces lydicus 103 and metabolic
            pathways analysis of antibiotic biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2016) Key Laboratory of Systems Bioengineering
            (Ministry of Education), Tianjin University, Tianjin 300072, PR
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001729485.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:23:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,288
            CDSs (total)                      :: 7,195
            Genes (coding)                    :: 7,061
            CDSs (with protein)               :: 7,061
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 47 of 134
            Pseudo Genes (incomplete)         :: 104 of 134
            Pseudo Genes (internal stop)      :: 11 of 134
            Pseudo Genes (multiple problems)  :: 26 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:52:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3656936
            Orig. end                         :: 3679549
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017157.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA is available from Prof. Ying-Jin Yuan.
            Annotation modified by submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22613
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="11"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22613
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22613
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12613](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12613)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    903..917
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.63"
                     /tool="antismash"
     misc_feature    complement(965..977)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.58"
                     /tool="antismash"
     gene            1035..1586
                     /locus_tag="SL103_RS15860"
                     /old_locus_tag="SL103_15860"
     CDS             1035..1586
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946995.1"
                     /locus_tag="SL103_RS15860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15860"
                     /product="response regulator transcription factor"
                     /protein_id="WP_069573768.1"
                     /transl_table=11
                     /translation="MRSALAALLRDEEQIDAVAACWGSAHGRARSFRPQVCVVDGDGAG
                     PMQDASPPGGPDCGLLVLASACRPGTLRRAVAAKARGFVDKDAPPARLRHAINLVAAGK
                     RYVDHTLTLDFLQAADMPLTPRELNVLQLAAGGASVPEIAHELHLSTGTVRNYMAAINR
                     KTGARNRVDAIRISQGAGWV"
     misc_feature    1311..1313
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    1416..1418
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1729..2559
                     /locus_tag="SL103_RS15865"
                     /old_locus_tag="SL103_15865"
     CDS             1729..2559
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141537.1"
                     /locus_tag="SL103_RS15865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15865"
                     /product="MOSC N-terminal beta barrel domain-containing
                     protein"
                     /protein_id="WP_069573769.1"
                     /transl_table=11
                     /translation="MPIVAELITYPVKGCAGVPLAEAGLTPAGLPHDRSFMVVSDRGVY
                     RTQRTDPRLAVIRPEVSSDGTQLILHQKGVESLRIEVDTTSPRKDVDLFGQPFRGIDQG
                     ETAAGWLSEVLGTDCRLVRVPPEHDRVADGRTPGTSGYADSSPLHILSLATFNDLNERL
                     AAAGKPPMPMTRFRPNIVLDGWQEPLTEDRVHRAEVGGAELGFAKLAVRCAVTMVDQET
                     GTKDGPEPLRTLASYRRVPEGGVAFGSKFSVVRTGKLAVGDEFTVTEWTAAGPS"
     gene            2588..3343
                     /locus_tag="SL103_RS15870"
                     /old_locus_tag="SL103_15870"
     CDS             2588..3343
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS15870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SL103_15870"
                     /product="hypothetical protein"
                     /protein_id="WP_069569687.1"
                     /transl_table=11
                     /translation="MAELIDNEPGRYGDRRPTRDQVIGRIADHIADRRPGHPLRVAVDG
                     ITAAGKTTLARALAAAVGERGRAAIHLSMDGFHHPRAHRHRQGRDSAIGYYQDAYDFPS
                     FARSVLVPLGPGGDHRYRSRIIDLASDQAIDEPPVTAPADAVLVVDGSFLQRHELAGLW
                     DEVVFADTSFPVARRRGTRRDTQLFGSTAAAEHAFDHRYHAACRHYLAEVDPAARATIV
                     VGNDDLDHPVLRRIDGAHTGTGHPHTFRT"
     gene            complement(3333..4160)
                     /locus_tag="SL103_RS15875"
                     /old_locus_tag="SL103_15875"
     CDS             complement(3333..4160)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-259). E-value:
                     1.5e-28. Score: 92.0. Matches aSDomain:
                     nrpspksdomains_SL103_RS15875_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059128.1"
                     /locus_tag="SL103_RS15875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15875"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_069569688.1"
                     /sec_met_domain="PF00561 (E-value: 5.7e-21, bitscore: 74.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.8e-21, bitscore:
                     74.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYFEGSDGTSLFYTDWGQGKPVVFVAGAWLSSSAWELQMLPLSE
                     QGLRCVAYDKRGHGRSDWVGHGFDYDTLADDLAALLDRLDLHDVTLVAHSMGGGEVIRY
                     LSRHGYDRVSKVVLIAVTAPLMLHTPDNPHGIDRSLFDALAAERTKDRPRWMAHNAQAF
                     FATHLGNQVSSELIAWTVQKCLDCSAKAAAEVVETGFSTDLRKEAGALQVPTLIIHGDA
                     DASAPIDLCARRLTHLVPDNTYKEYPGAGHGIFLTHATQLNQDLRDFIEGATS"
     aSDomain        complement(3384..4100)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS15875_Abhydrolase_1.1"
                     /evalue="1.50E-28"
                     /label="SL103_RS15875_Abhydrolase_1.1"
                     /locus_tag="SL103_RS15875"
                     /protein_end="259"
                     /protein_start="20"
                     /score="92.0"
                     /tool="antismash"
                     /translation="KPVVFVAGAWLSSSAWELQMLPLSEQGLRCVAYDKRGHGRSDWVG
                     HGFDYDTLADDLAALLDRLDLHDVTLVAHSMGGGEVIRYLSRHGYDRVSKVVLIAVTAP
                     LMLHTPDNPHGIDRSLFDALAAERTKDRPRWMAHNAQAFFATHLGNQVSSELIAWTVQK
                     CLDCSAKAAAEVVETGFSTDLRKEAGALQVPTLIIHGDADASAPIDLCARRLTHLVPDN
                     TYKEYPGAGHGIFLTHA"
     gene            complement(4278..5930)
                     /locus_tag="SL103_RS15880"
                     /old_locus_tag="SL103_15880"
     CDS             complement(4278..5930)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (96-258). E-value:
                     5.9e-17. Score: 54.0. Matches aSDomain:
                     nrpspksdomains_SL103_RS15880_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091023.1"
                     /locus_tag="SL103_RS15880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15880"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_069569689.1"
                     /sec_met_domain="PF00561 (E-value: 5.3e-20, bitscore: 70.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRISGPIAVRRNRAAVIAVALSCYVALTGPGLGTADAPPAPAVPA
                     PAPDWRPCPRDGHFDCATAKVPLDYGDPRGRTLDLAVVRHKATRPGRRIGTLFFNPGGP
                     GGPGTVQMPQNYPLFPREVRERFDIVSWDPRGVGHSTAVNCFATPKESAAWLAARPSGF
                     PVGARQRNIWIAAYRDLGRRCAQRDAALLRHVSTADSARDLDRLRRWVGDPKLTYLGAS
                     YGTILGATYANLFPGRVRALVLDSNIAPSAWTNHGDDAARLPTFLRLGSDRSAAATLDQ
                     FLTLCGSTTTAGCAFSAGGPDATRDKFNGLMRRLRERPAGTWTYARTVADTINGLYVVR
                     PGWSEVAALLQRLWQGRTPGPSAPLPTPPVPVPYTGEEQAAAILCGDSPNPRDPGVFHP
                     LEEAGAARAGDAGRYWTWASEPCATWPTVAADRYTGPWNRPTAATVLVVGTLYDPATPY
                     RDAQAMAEELAHARLLTNIGYGHTALVNPSGCVNAYESRYLIDGTLPPPGTTCRQDDPP
                     FPPRRPRGGVDAGGGGAAGLVPNRPWRSGPSTR"
     aSDomain        complement(5157..5642)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS15880_Abhydrolase_1.1"
                     /evalue="5.90E-17"
                     /label="SL103_RS15880_Abhydrolase_1.1"
                     /locus_tag="SL103_RS15880"
                     /protein_end="258"
                     /protein_start="96"
                     /score="54.0"
                     /tool="antismash"
                     /translation="LFFNPGGPGGPGTVQMPQNYPLFPREVRERFDIVSWDPRGVGHST
                     AVNCFATPKESAAWLAARPSGFPVGARQRNIWIAAYRDLGRRCAQRDAALLRHVSTADS
                     ARDLDRLRRWVGDPKLTYLGASYGTILGATYANLFPGRVRALVLDSNIAPSAWTNHGD"
     gene            complement(6133..7914)
                     /locus_tag="SL103_RS15885"
                     /old_locus_tag="SL103_15885"
     CDS             complement(6133..7914)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946994.1"
                     /locus_tag="SL103_RS15885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15885"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_069569690.1"
                     /transl_table=11
                     /translation="MTPVTVRLLPRALRFLRARARVLLLMGGWSLLESAHTFLGGYSVA
                     KALDDGFLAGRTATGLTWLAVAAVAVVLGGLAGRGVFRGLAGLVEPLRDALVGAVVARA
                     LDEAVADPARAADTAVVSRLTNQTELARDSFAGLVLVARSFVFTAAGALVGLVSLAPQL
                     LLIVLPPLAGGLLLFVATLVPMARRQRAFLRADETLSAEFGAVAAGLRDVVACGARGEV
                     AARAHALIDAEERAARHLAGWAAARAVALGVAGQLPVLLLLVSTPWLLREHLTAGAVLG
                     ALTYLTQALLPALHTLMNALGSGGTRLLVVLDRLTRPARTPDVRSAPDDHAPGHTDTRA
                     PRSACPSPGLPAGPRVELRAVTFAYGPAAQPVLHDLDLVVEPGEHLAVVGPSGIGKSTL
                     TGLLAGLLHPVSGDVRVDGLPPGAAYRPDPARLRVLIPQQAYVFSGTVRDNLLYLCPDG
                     ASAAALEATSHAVGLGPLLSRLGGLDARVDPATLSQGERQLLALGRAHLSPAPLVLLDE
                     ATCHLDPAAEQRAEGAFADRPGTLIVIAHRISSARRADRILVLDGNRATAGSHAELLER
                     SALYRELAGNWQPERSR"
     gene            complement(7911..9680)
                     /locus_tag="SL103_RS15890"
                     /old_locus_tag="SL103_15890"
     CDS             complement(7911..9680)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570340.1"
                     /locus_tag="SL103_RS15890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15890"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_069569691.1"
                     /transl_table=11
                     /translation="MPAPPGPPSPTRPPATGRQPDPGTAVLTDAFRHSPVHTVAVCLFG
                     VAGAGVAIALPAVLGHTLDLVLDSAPGAGAALTLSAVLLVADVLLDALVALAGGVTTAR
                     SIAWLRRRGIGHLLSLAPHRAADRFTAGDLVTRLTGNAAEAGTAPTTAATGLAAVLTPV
                     GALVALALTDVWLAAVFLAGLPLLTRLLRTFARGSSDCVRRYQRVQAEIASRLVEALGG
                     ARTIAAAGTGARERARVLAPLPELDAQGRLMWQVYGRAVVGSGILVPLLTTVVLAVGGL
                     RLAHGALTVGELLAASRYAALTAALGGVTGQLNALVRGRAAARRTAELLALPQVRYGAR
                     PLPADGRGRLELRGVTVARDGAPVLRGVDLAVPGGTTLAVVGHSGAGKSLLAAVAGRLT
                     DPDSGQVLLDGVPLAEADPAQLRREIGYAFERPALFGETVGAALAFGPDRPAAPAVESA
                     ARAAGADTFVRLLPRGYATPLADAPLSGGELQRLGVARAFAHAGRLLILDDATSSLDTV
                     TEHHVSRALLEDVRPGTRLLITHRLASAARADLVAWMDGGRIRAVAPHALLWQDADYRA
                     VFAGTAPDPRTAS"
     gene            complement(9810..9938)
                     /locus_tag="SL103_RS15895"
                     /old_locus_tag="SL103_15895"
     CDS             complement(9810..9938)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849360.1"
                     /locus_tag="SL103_RS15895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15895"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_033265003.1"
                     /transl_table=11
                     /translation="MSLLDLQTMETPKPEGTEELHTGSRASLLLCGDSSLSVTTCN"
     CDS_motif       complement(9876..9938)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSLLDLQTMETPKPEGTEELH"
                     /locus_tag="SL103_RS15895_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9810..9875)
                     /prepeptide="core"
                     /locus_tag="SL103_RS15895_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="12.30"
                     /molecular_weight="1941.2"
                     /monoisotopic_mass="1940.0"
                     /core_sequence="TGSRASLLLCGDSSLSVTTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLLDLQTMETPKPEGTEELH"
                     /leader_location="[9875:9938](-)"
                     /alternative_weights="1959.2"
                     /alternative_weights="1977.2"
                     /alternative_weights="1995.2"
                     /alternative_weights="2013.2"
                     /alternative_weights="2031.3"
                     /alternative_weights="2049.3"
     misc_feature    complement(9911..9931)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            complement(10001..12613)
                     /gene="lanKC"
                     /locus_tag="SL103_RS15900"
                     /old_locus_tag="SL103_15900"
     CDS             complement(10001..12613)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020551010.1"
                     /locus_tag="SL103_RS15900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15900"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_069569692.1"
                     /sec_met_domain="micKC (E-value: 2.4e-244, bitscore: 811.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.1e-11, bitscore: 42.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.6e-11, bitscore:
                     40.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKGYAVFCDADRQFYDAPHRLPSDKEGRGALYPVLRRELPGGWQ
                     RHRSGDWLAFRPLDRELPSQGWKIHVSACLDNAERILEKVWDYCVPRSVAFKCMPSRYL
                     LHIRNAKYTDRGASGKFVTVYPADAEQCRVIAEELNALLAGESGPYILSDLRWGTGPVY
                     VRYGSFTERHCYDDKGELCPAIEDDRGRLVPDRREPAFRVPEWVDLPDFLKPHLDARSA
                     TTVSDLPYAIERALHFSNGGGVYVGRDLRTERRVVLKEGRPHAGLAADGADAVTRLARE
                     RDALRRLSGLGCAPEVLDWFTLGEHTFLVLEYIEGRPLNSFFAHRHPLIEADPSAERLA
                     EYTQWALRVHRLVEEAVEAIHARGVVFNDLHLFNIMLSEDESSVVLLDFEAASVDDPAS
                     RQVIANPGFVAPADRRGADVDRYALACLRLALFLPLTSLFAVDRHKARHLARIAAEQFP
                     VPREFLDAAVTEILRGHPVPHPPASAQPPSTDAYLPVALGDWPRSRDSAVRAVLASATP
                     EREDRLFPGDIAQFATAGGGTCFAYGAAGVLYALDATGAERCPDAEEWLLQRTKTPASG
                     SPLGFYDGLSGVAWVLDRLGHRERALDLVDLVTAQDWQDIAPDLHSGLAGVGLALDALA
                     GSTGESAARDQALRCAELVAHRLRSAAPPTAPADGTTAPSRAGLLHGDSGAALLFLRLY
                     ERTGDGALLDLAAEALRRDLARCVRSAGGTLQVNEGWRTMPYLGAGSVGIGMVLDDYLV
                     HRPDDAFAAARDEIVQAAQAKFYAQPGLFRGAAGMVLYLSRTTATGPGTDAADLHRQIE
                     SLSWGAVPYRGHLAFAGEQMMRLSMDLSTGTAGCLLALGSALHDSPVHLPFLPPLRRP"
     misc_feature    complement(11135..11137)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12635..12650)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     misc_feature    complement(12662..12677)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.12"
                     /tool="antismash"
     gene            complement(12877..13050)
                     /locus_tag="SL103_RS15905"
                     /old_locus_tag="SL103_15905"
     CDS             complement(12877..13050)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017949262.1"
                     /locus_tag="SL103_RS15905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15905"
                     /product="CsbD family protein"
                     /protein_id="WP_069569693.1"
                     /transl_table=11
                     /translation="MTAEKKTSAKADQLKGAVKETLGRAVGNERMTAEGRAERAKGDMR
                     QAGHKAQDALKR"
     gene            13236..13973
                     /locus_tag="SL103_RS15910"
                     /old_locus_tag="SL103_15910"
     CDS             13236..13973
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (38-141). E-value: 9.4e-14. Score:
                     42.2. Matches aSDomain: nrpspksdomains_SL103_RS15910_oMT.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151373.1"
                     /locus_tag="SL103_RS15910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15910"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_069569694.1"
                     /transl_table=11
                     /translation="MNREQMSRIAHSGHPIKAPLDDASVRRLLERGTPRGDERLLDLGC
                     GSAEWLLRALATGPQLHAVGVDISDDALTQAREAADRRGLGERLVLHHGAAADFVSPDP
                     FDLVLSVGAAHAFGGLLPTLAAARAHLAPGGQVLIGDGFWEHPPSPEAVEMLGDFTDLA
                     STVDRVVADGWTPVHGHVSSRQELDAYEWACWGTLAAWGLDRPTDPDGPRALAMAATRR
                     SEWLRSYRDTWGFVTLLLRRTAD"
     aSDomain        13350..13658
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS15910_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="9.40E-14"
                     /label="SL103_RS15910_oMT.1"
                     /locus_tag="SL103_RS15910"
                     /protein_end="141"
                     /protein_start="38"
                     /score="42.2"
                     /tool="antismash"
                     /translation="RLLDLGCGSAEWLLRALATGPQLHAVGVDISDDALTQAREAADRR
                     GLGERLVLHHGAAADFVSPDPFDLVLSVGAAHAFGGLLPTLAAARAHLAPGGQVLIGD"
     gene            complement(14092..15114)
                     /locus_tag="SL103_RS15915"
                     /old_locus_tag="SL103_15915"
     CDS             complement(14092..15114)
                     /NRPS_PKS="Domain: PKS_ER (19-266). E-value: 5.7e-12.
                     Score: 37.3. Matches aSDomain:
                     nrpspksdomains_SL103_RS15915_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982795.1"
                     /locus_tag="SL103_RS15915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15915"
                     /product="alcohol dehydrogenase"
                     /protein_id="WP_069569695.1"
                     /sec_met_domain="ADH_N (E-value: 2.6e-27, bitscore: 93.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.4e-20, bitscore:
                     70.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAYRVAQVAAAGGSFEVVEREVPRPGAGQVRLAVEACGICHSDA
                     LFVEAVLPGVRFPLVPGHEIAGRIDEIGAATPGDWQVGDRVVVGWFGGSCHSCTPCRRG
                     DFVVCENLKVPGWAYDGGFGETVIAPADALARIPDTVPATEAGPMACAGVTTFNGLRRS
                     SARPGDLVAVLGIGGLGHLGVQYAAAMGFETVALARGADKADFARQLGAHHYIDTTAGT
                     PVADALQALGGAKAVLATAANSQAITSTVEGLSPRGELIVVGADTAPLGISPAQLLMQG
                     KVVRGHPSGTAQDVQETMAFSALHGIRPMIETVPLDRADEAYRKMLSGAARFRMVLTTG
                     "
     aSDomain        complement(14317..15057)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS15915_PKS_ER.1"
                     /evalue="5.70E-12"
                     /label="SL103_RS15915_PKS_ER.1"
                     /locus_tag="SL103_RS15915"
                     /protein_end="266"
                     /protein_start="19"
                     /score="37.3"
                     /tool="antismash"
                     /translation="EREVPRPGAGQVRLAVEACGICHSDALFVEAVLPGVRFPLVPGHE
                     IAGRIDEIGAATPGDWQVGDRVVVGWFGGSCHSCTPCRRGDFVVCENLKVPGWAYDGGF
                     GETVIAPADALARIPDTVPATEAGPMACAGVTTFNGLRRSSARPGDLVAVLGIGGLGHL
                     GVQYAAAMGFETVALARGADKADFARQLGAHHYIDTTAGTPVADALQALGGAKAVLATA
                     ANSQAITSTVEGLSPRGELIVVGAD"
     gene            complement(15376..15762)
                     /locus_tag="SL103_RS15920"
                     /old_locus_tag="SL103_15920"
     CDS             complement(15376..15762)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735796.1"
                     /locus_tag="SL103_RS15920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15920"
                     /product="VOC family protein"
                     /protein_id="WP_069569696.1"
                     /transl_table=11
                     /translation="MNITSSALSLTVDDVPASAAFLVKHFGFQEAMAADGFASLAREDA
                     PNVIFLRRGIEVLPEGFRDQRAAGVIIAFTVADLDAEFERLSSEGAPITMPLREEPWGE
                     RLFQVTDPNGVILQLVAWAGPEHR"
     misc_feature    complement(15747..15761)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.02"
                     /tool="antismash"
     misc_feature    complement(15805..15823)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.7"
                     /tool="antismash"
     gene            15865..16647
                     /locus_tag="SL103_RS15925"
                     /old_locus_tag="SL103_15925"
     CDS             15865..16647
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547892.1"
                     /locus_tag="SL103_RS15925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15925"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069569697.1"
                     /transl_table=11
                     /translation="MAKEHRGTSDPARILELLWREPGHGDSRRGPKQGLTVDAVVRVAV
                     ELADADGLEALTMRGIAQRLGVTPMTLYTYVPGKTELLDLMLDAVYLQMPRSDRSADPW
                     RTRVAAVADENRALYDRHPWVATVLTARPPLGPGLMTKYEHELAAFDGLGLDDVERDAA
                     LTLVLDFVQSVARGNLAARAAARDSAMSDQQWWAANAPLLAKVFDPDRFPLAARVGSAA
                     GAAHQGMYSPDHAFDFGLRCILDGLAHLAGCEDSADTP"
     gene            complement(16714..17091)
                     /locus_tag="SL103_RS15930"
                     /old_locus_tag="SL103_15930"
     CDS             complement(16714..17091)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057039.1"
                     /locus_tag="SL103_RS15930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15930"
                     /product="DUF2267 domain-containing protein"
                     /protein_id="WP_069569698.1"
                     /transl_table=11
                     /translation="MDDKEFFRAVAERSGLSRQEAADLTRATLDTLGHRLSGGEARDLA
                     LELPEPLRGSLQAGQGEMEIFGPAESIRRVGVHTGLTEPEAARGVRAVLSTLQEAVSQK
                     EFAHAMSQLGKEYAQLVEATR"
     misc_feature    17216..17231
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.44"
                     /tool="antismash"
     misc_feature    17271..17286
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 25.48"
                     /tool="antismash"
     gene            17307..18539
                     /locus_tag="SL103_RS15935"
                     /old_locus_tag="SL103_15935"
     CDS             17307..18539
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142647.1"
                     /locus_tag="SL103_RS15935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15935"
                     /product="carbohydrate-binding protein"
                     /protein_id="WP_079145768.1"
                     /transl_table=11
                     /translation="MPPRNVRTFAAVASAACLALVAAGTALATGHGAAAPAREAVGSNW
                     YAAAPYLMPLDNDPPDAAAVMDATGLKAFQLAFLLAPNGGGCSPTWGGTGPVSSDTAVA
                     GVIATIRAKGGDVSASVGGYGGTKLGQTCGTPEATAAAYQQAIDKYGLKALDFDLEEPE
                     YENAAAIHNEIGAAKILQQKNPGIYLSVTTAGTADGTGWFGKQMLNEAKAQSFTPDNFS
                     IMPFDGGFNGAASQTAALTNFNSVLRSTFGWDEATAYAHEGISQMNGRSDTGEYFTQAD
                     FQTVLDFATAHHLARFTNWSVNRDRQCSPPDNNGKTSGTCSSVPQGAYDFTKYSVRFAG
                     ATPPTTPPTTPPTTPPGNGGCTAAAYGAGTVYVGGDTVSYQGHTWRARWWTQGEAPSTG
                     GSGVWQDLGAC"
     gene            complement(18657..20276)
                     /locus_tag="SL103_RS15940"
                     /old_locus_tag="SL103_15940"
     CDS             complement(18657..20276)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716965.1"
                     /locus_tag="SL103_RS15940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15940"
                     /product="M4 family metallopeptidase"
                     /protein_id="WP_069569699.1"
                     /transl_table=11
                     /translation="MRRISSTPRKNTLRAAALVASAAMVAVGVQAGSASAQPDRATGAS
                     AVQLSAAQRATALKSAQSDASATAAKIGLGAREKLVVRDVIKDADGTVHTRYERTFDGL
                     PVLGGDLVVHQAKNGAHSVTKATNARISVASTAAPLAPSAARKSALRAAAAVKDSKTDA
                     SGTPRKVIWAATGKPVLAYETVVTGVQKDGTPSRLHVITDAATGKKLWQNEAIETGTGT
                     STYSGKVALTTTKSGTTYQLTDGARGGHKTYDLNQKTSGTGTLFTDADDVWGGGRQTAG
                     VDAHYGAAVTWDFYKNTFGRNGIRGDGKGAYSRVHYGNSYVNAFWDDGCFCMTYGDGSG
                     NTHPLTSLDVAAHEMSHGVTAATAGLNYSGESGGLNEATSDIFGTSAEFYANNSSDPGD
                     YLIGEKIDINGDGTPLRYMDKPSKDGASADYWSSTVGNKDVHYSSGVANHFFYLLSEGS
                     GAKVIGGVSYNSPTYNGSKLTGIGRDKAEKIWYKALTTYMTSTTNYKAARTATLKAAGD
                     LYGTTGTEYKAVGAAWTGLNVN"
     misc_feature    complement(20351..20366)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.28"
                     /tool="antismash"
     misc_feature    20388..20404
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.29"
                     /tool="antismash"
     misc_feature    20392..20401
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.64"
                     /tool="antismash"
     misc_feature    complement(20398..20415)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.82"
                     /tool="antismash"
     misc_feature    complement(20409..20426)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.56"
                     /tool="antismash"
     misc_feature    complement(20418..20432)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.46"
                     /tool="antismash"
     misc_feature    complement(20440..20457)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.54"
                     /tool="antismash"
     misc_feature    complement(20543..20557)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.96"
                     /tool="antismash"
     misc_feature    20544..20558
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.09"
                     /tool="antismash"
     gene            20598..21029
                     /locus_tag="SL103_RS15945"
                     /old_locus_tag="SL103_15945"
     CDS             20598..21029
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981076.1"
                     /locus_tag="SL103_RS15945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15945"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_069569700.1"
                     /transl_table=11
                     /translation="MNEHFYSVEQVAEHLGLHVRTVRNYVRDGRLPAVRIGKQYRIAHE
                     DLEAFTGRPAPSPGSRAGGRPPHAEVSSIVQIDAVDAGTAGRLAGLLMSAAAHGRPGGA
                     PLRIETAHDPERARMKVIVLGSPGDTARLLEYMEGVLAS"
     gene            21026..21865
                     /locus_tag="SL103_RS15950"
                     /old_locus_tag="SL103_15950"
     CDS             21026..21865
                     /NRPS_PKS="Domain: Abhydrolase_1 (51-159). E-value:
                     7.3e-17. Score: 53.7. Matches aSDomain:
                     nrpspksdomains_SL103_RS15950_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981077.1"
                     /locus_tag="SL103_RS15950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15950"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_069569701.1"
                     /sec_met_domain="PF00561 (E-value: 8.5e-13, bitscore: 47.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.5e-15, bitscore:
                     54.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIYKSEAGAQEIQRRYREALDAWPVPAEQLRVPTREGETFVLV
                     SGPEDAPPVVLLHGAGANATMWQDDITTWARHFRTYAVDLIGEPGLSAPSRPPLASDAP
                     ARWLDDVLEALGITRAAFVGTSLGGWLALDHATRRPERVDRLALLCPGGVGRQRMGWLF
                     KALLLRPLGARGVRRSAGAVAGLDRPEHRAVLDQLVLTFAQFKPRTERLPVFPDDALRR
                     LAMPVQVTVGGRDALFDSAGTARRTARCVPHATVRVLPEAGHALLGQTDAVLTFLRH"
     aSDomain        21179..21502
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS15950_Abhydrolase_1.1"
                     /evalue="7.30E-17"
                     /label="SL103_RS15950_Abhydrolase_1.1"
                     /locus_tag="SL103_RS15950"
                     /protein_end="159"
                     /protein_start="51"
                     /score="53.7"
                     /tool="antismash"
                     /translation="PPVVLLHGAGANATMWQDDITTWARHFRTYAVDLIGEPGLSAPSR
                     PPLASDAPARWLDDVLEALGITRAAFVGTSLGGWLALDHATRRPERVDRLALLCPGGVG
                     RQRM"
     gene            21888..22595
                     /locus_tag="SL103_RS15955"
                     /old_locus_tag="SL103_15955"
     CDS             21888..22595
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018892335.1"
                     /locus_tag="SL103_RS15955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_15955"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_244303920.1"
                     /transl_table=11
                     /translation="MPTTEMLGRIATSTDRFVRTVTTLTDADIRGATLVPPWTRGHVIT
                     HVARAADSLCRLLTWARTGVETPQYTGMDARAAEIEAGARRPVDALVADVLASAARFDD
                     AVRSLPDAAWTYEVRMRTGEPRTPAALMVSRLRELEVHHADLATGYTFADIPPEAARWI
                     IDDLVEAQRRRDGTPPLRIEATDTGLSRELGSGGPTVRGSQADLLGWLTGRTGGATLTT
                     TAPGPVPDAPYWI"
ORIGIN
        1 cgacgccccg gggctgggcc tcgccctcct ggcggggtgt tgctggggcg gctacatcct
       61 cgtcggcgca cgcctcgccg cacgcgtccc cgacgggcgg ggcctggccc tcgccgtcac
      121 gtggggagcc ctgctgagcc tcccgtacgg gatcgcccgg gcgggggcca ggctgctgga
      181 ccccggcacc ctcgcgccgg ccctcgtcat cgcggtcctc tccagcgtgc tgccctacac
      241 ctgccacctg gaagccctgc gccggctgcc gccccgcgtc ttcggcgttc tgaccagcct
      301 cgaacccgcc gtcggcgccc tcgtcggact gctcctcctc gggcagcacc tcgccgcgcc
      361 gcagtgggcg ggagtgctcg cggtggccct cgcctccgtc ggcgccaccc gcaccccggg
      421 ccccggtgcg aaagcggttg tcgaggagcg gtcggaaacg tagggaagcc cgcgcggggg
      481 ccgcccccgg gcatgccgac cgcgtcgggt gggcgtcctg ctgacccgga ctttcgcacc
      541 ccttttcacg cgtgccaccc gcgcctcatt gggcacagcc gccaccacgg caccgtgagt
      601 gtgcccagcc ggcgaacggg cgtggtaagt agccacgttc acgatggcgg gaagtcgctg
      661 tccccggcgc cgtgcggctt ccggaaacag tggcccgccg tgtgtgagat tcctacgact
      721 tcgctaccgc gaaggagatc ggggggcggg cgaggccggt gaggtgccgc gccgagcgcg
      781 tgggcagggc gccaacggcg gcaggtggcg cgtcgaccgg tggccgcggg gtgtgcgagg
      841 agttgtgggc tcctgtcata aggcaacgca atggacgcaa tgtcagtgcg acaagggggc
      901 gtcttttcca gtcaattccg gtgaaggttc gactggcggg aatgcggacg atgacaattc
      961 agcagtgcaa accgcatggc cgacatgaag gggcgtaagt gatccgggtc ttggtggtcc
     1021 atgagacgcg gctgatgcga tcggcgctgg ccgcgctgct gcgtgacgag gagcagatcg
     1081 acgcggtcgc ggcctgctgg ggaagcgctc atggcagagc gcgttccttc cggccccagg
     1141 tgtgtgtggt ggacggcgac ggggcgggac cgatgcagga cgccagccct ccgggcggtc
     1201 cggactgcgg cctgctcgtt cttgcgagcg cctgccggcc cggcacgctc cggcgggccg
     1261 tcgccgccaa ggcccgtggc ttcgtcgaca aggacgcgcc gccggcccgg ttacggcacg
     1321 ccataaacct ggtcgcggcc ggcaagcgct acgtcgacca cacgctgacg ctggacttcc
     1381 tccaggccgc cgacatgccg ctcaccccac gcgagttaaa cgtgctgcaa ctggccgcgg
     1441 gcggggcgtc cgtacccgag atagcccatg aactgcatct gagcacgggc acggtgcgca
     1501 actacatggc ggccatcaac cgcaagaccg gcgcccgcaa ccgggtcgac gccatacgca
     1561 tctcgcaggg cgccggctgg gtctgagcgc cggccggcac cgccccggag cagaagctgc
     1621 aggaggcata cgtgatctgc gcacacatct ggccgaccag cgccggtccg agcacctggg
     1681 gcagggaaag cgcgtgatgc gtgggcgagg catccataag gtgtgtccat gcctatagtt
     1741 gccgaactga tcacctatcc cgtcaagggg tgcgccgggg tccccctggc ggaggccgga
     1801 ctcacgccgg cgggactccc gcacgaccgc agcttcatgg tcgtcagcga ccggggcgtg
     1861 taccgcaccc agcgcaccga tccccggctc gcggtgatcc ggcccgaagt gagctccgac
     1921 ggcacccaac tcatcctgca tcaaaagggc gttgagtcct tgcgcatcga ggtggacacc
     1981 acctcgcccc ggaaggacgt cgacctcttc ggccagccgt tccgcggcat cgaccagggt
     2041 gagaccgcag ccggctggct gtccgaggta ctcggcacgg actgccgact ggtgcgggta
     2101 ccgccggagc acgaccgggt ggccgacggc cgcacccccg gcacctccgg ctacgccgac
     2161 agcagcccgc tgcacatcct ttccctggcc accttcaacg acctcaacga gcggctggcg
     2221 gcagcgggga aaccaccgat gccgatgacc cggttccggc cgaacatcgt gctggacggg
     2281 tggcaggagc cgctcacgga ggaccgggtg caccgggccg aggtgggcgg tgccgagctg
     2341 gggttcgcca agctcgccgt gcgctgcgcc gtcaccatgg tcgaccagga gaccggcacc
     2401 aaggacggac cggagccgct gcggacactc gcctcctacc gacgggtgcc cgagggcggg
     2461 gtggccttcg gctcgaagtt ctccgtcgtg cggaccggga aactggccgt gggagacgag
     2521 ttcacggtca cggaatggac ggcggccggc ccttcctgac cgagcccggg tcactaagat
     2581 ccgcatcatg gcagaactga tcgacaacga gccgggccgg tacggcgatc gccggcccac
     2641 ccgggaccag gtcatcggtc gcatcgccga ccacatcgcc gaccggcggc cagggcatcc
     2701 gctgcgggtc gcggtggacg gcatcaccgc cgccggaaag accaccctcg cccgcgccct
     2761 ggccgcggcg gtgggtgagc gcggccgagc ggccatccat ctgtccatgg acggcttcca
     2821 ccacccgcgc gcgcaccgtc accggcaggg ccgcgactcc gcgatcggct actaccagga
     2881 cgcctacgac ttcccctcgt tcgcacggtc cgtcctcgtc cccctcggac ccggcggcga
     2941 tcaccgctac cgcagccgca tcatcgacct ggccagcgac caggcgatcg acgagccacc
     3001 ggtcaccgcc cccgccgacg cggtcctggt ggtcgacggc agcttcctgc agcggcacga
     3061 actggccgga ctgtgggacg aggtcgtgtt cgccgacacc agcttccccg tcgcccgccg
     3121 ccgcggcacc cgccgcgaca cccagctgtt cggcagcacc gcggcggccg agcacgcctt
     3181 cgaccatcgc taccacgccg cctgccggca ctacctggcc gaggtcgacc cggccgcgcg
     3241 ggcgacgatc gtcgtcggca acgacgacct cgatcacccc gtgctgcggc ggatcgacgg
     3301 cgcgcacacc ggaacgggcc acccccacac gttcaggacg tagcgccctc gatgaagtcg
     3361 cggaggtcct ggttgagttg tgtggcgtgg gtgaggaaga tgccgtgtcc cgcgccgggg
     3421 tactccttgt aggtgttgtc cggtacgagg tgtgtcagtc gtcgtgcgca caggtcgatg
     3481 ggtgcggagg cgtcggcgtc gccgtggatg atcagtgtgg gtacctggag tgcgcctgct
     3541 tccttgcgca ggtcggtgga gaagccggtc tcgacgactt cggcggctgc cttggccgag
     3601 cagtcgaggc acttttgcac cgtccaggcg atgagttcgc tggagacctg gttgcccagg
     3661 tgtgtggcga agaatgcctg ggcgttgtgg gccatccacc gcgggcggtc cttggtccgt
     3721 tccgctgcca gggcgtcgaa gaggctgcgg tcgatgccgt gggggttgtc cggggtgtgg
     3781 agcatcagtg gtgcggtgac ggcgatcagt accaccttgc tcacccggtc gtagccgtgc
     3841 cgggagaggt agcggatcac ttcgccgccg cccatcgagt gtgccaccag cgtcacgtcg
     3901 tgcaggtcga ggcggtcgag cagggcggcg aggtcgtcgg cgagggtgtc gtagtcgaag
     3961 ccgtggccga cccagtcgga gcggccgtgg ccccgcttgt cgtaggcgac gcagcgcagg
     4021 ccctgttcgg acagcggcag catctgcagt tcccacgcgc tgctgctgag ccaggctccg
     4081 gcgacgaaga cgaccggctt gccctgtccc cagtcggtgt agaacaggct tgttccgtcg
     4141 gagccttcga agtacggcat gtgtgggtcc ttcctggacg gtgcggtgtc gctgtgccga
     4201 caactctcgt ccaaggggcg gcacaccgtc gattacccca caggtaacgg tgcggcccga
     4261 acgcgccgtg cgcgtcgtca gcgcgtgctc gggccgctgc gccagggccg gttcgggacc
     4321 agcccggccg ccccgccgcc gccggcgtcg acgccgccgc gcggacgacg gggcgggaag
     4381 ggcgggtcgt cctgccggca cgtcgttccc ggcggcggaa gggtgccgtc gatgaggtag
     4441 cggctctcgt acgcgttgac gcagccgctg ggattgacca gtgcggtgtg cccgtacccg
     4501 atgttggtga gcagccgggc gtgggccagc tcctcggcca tggcctgcgc gtcccggtag
     4561 ggcgtggcgg ggtcatagag ggtgccgacc accaggacgg tggccgccgt cggcctgttc
     4621 cacgggccgg tgtagcggtc ggcggccacg gtgggccacg tggcgcacgg ctccgacgcc
     4681 caggtccagt agcgcccggc atcgccagca cgggcggcac ccgcctcttc cagggggtgg
     4741 aagacgccgg ggtcacgcgg gttggggctg tcgccgcaga ggatggcggc ggcctgttcc
     4801 tcacccgtgt acgggaccgg gaccggaggc gtgggcagcg gtgcggaggg ccccggggtg
     4861 cggccctgcc acagcctctg gagcagggcg gcgacctcgg accatccggg gcggacgacg
     4921 tagaggccgt tgatcgtgtc cgccaccgtc ctggcgtagg tccaggtgcc ggccggccgt
     4981 tcacggaggc gccgcatcag cccgttgaac ttgtcccggg tcgcgtccgg gccgccggcg
     5041 gagaaggcac agcccgccgt ggtggtggag ccgcacaggg tgaggaactg gtccagggtc
     5101 gccgccgcgg aacggtccga gcccaggcgc aggaaggtcg gcagccgggc ggcgtcgtcg
     5161 ccgtggttcg tccaggccga cggggcgatg ttgctgtcga ggaccagggc gcggaccctg
     5221 ccggggaaga ggttggcgta ggtggcgccg aggatcgtgc cgtaggaggc ccccaggtag
     5281 gtgagcttcg ggtcgcccac ccaccggcgg agccggtcga ggtcgcgcgc ggagtcggcg
     5341 gtcgacacat gacgcagcag cgcggcgtcg cgctgcgcgc agcggcggcc caggtcccga
     5401 tacgcggcga tccagatgtt ccgctgccgc gcgccgaccg ggaagccgct gggtctggcg
     5461 gcgagccagg ccgcgctctc cttgggggtc gcgaagcagt tcacggccgt gctgtggccg
     5521 accccgcgcg ggtcccagct gacgatgtcg aaccgctccc gcacctcgcg cgggaacaac
     5581 gggtagttct gcggcatctg gaccgtaccg ggcccgccgg ggccgccggg gttgaagaac
     5641 agggtgccga tgcgccgtcc gggccgggtc gccttgtgcc gtacgaccgc caggtcgagg
     5701 gtgcgtccgc gcgggtcgcc gtagtccagc ggcaccttcg cggtcgcgca gtcgaagtgc
     5761 ccgtcccgag ggcacggccg ccagtccggt gccggcgcgg gcaccgccgg tgccggtggg
     5821 gcgtccgccg tgccgaggcc cggtccggtg agtgcgacgt agcagctcag cgccacggcg
     5881 atgaccgcgg cccggttccg gcggactgct atcggtccgg atatgcgcat gcgtcgtcct
     5941 cccacggacc gggcacccgt cgcacccggg caacggatgc cgacggcacc cgagcccacc
     6001 ccaccgcgcc gcggcaccgg acgcgagcgg ccgggggccg aacggctgag ccggcggccg
     6061 gacagccgaa caggtgccga tcccgcctgc gcggagcgtc atcccggcgc cgccgtacgc
     6121 cgcgggcacc gctcagcggg agcgctccgg ctgccagttc ccggcgagtt cgcggtagag
     6181 ggccgagcgt tcgagcagct cggcgtggct gcccgcggtg gcccggtttc cgtccagcac
     6241 gaggatccgg tcggcccgcc gggcggagct gatgcggtgg gcgatgacga tcagtgtgcc
     6301 gggccggtcg gcgaaggcgc cctcggcgcg ctgctccgcc gcggggtcga gatggcaggt
     6361 ggcctcgtcg aggaggacga gcggggcggg ggagaggtgg gcccggccga gggcgaggag
     6421 ctggcgttcg ccctgggaca gcgtcgccgg gtcgacccgg gcgtccagcc cgcccaggcg
     6481 ggagagcaac gggcccagcc cgaccgcgtg cgacgtcgct tccagggcgg ccgccgacgc
     6541 cccgtcgggg cacaggtaga gcaggttgtc gcgcacggtc ccggagaaga cgtacgcctg
     6601 ctgggggatg aggacccgga gccgggcggg gtcgggcctg tacgccgcgc ccggtggcag
     6661 tccgtccacc cggacgtcgc cgctgacggg gtgcagcagg ccggcgagga gaccggtcag
     6721 ggtggacttg ccgatgccgc tcggaccgac gacggcgagg tgttcgcccg gctcgacgac
     6781 gagatcgagg tcgtggagca ccggttgtgc ggcgggcccg tacgcgaagg tgaccgcccg
     6841 cagttcgacg cgtgggcccg ccgggagccc gggggacggg cacgcggagc ggggggcccg
     6901 cgtgtcggtg tgcccggggg catggtcgtc gggagcggag cggacgtccg gtgtccgcgc
     6961 gggccgggtg agccggtcca gtacgaccag gagccgggtg ccgcccgagc cgagggcgtt
     7021 catcagggtg tgcagggccg gcagcagcgc ctgggtcaga taggtcagcg caccgagcac
     7081 ggcaccggcg gtgaggtgct cccgcagcaa ccacggggtg ctgaccagta gcaggaggac
     7141 cggtagctgc ccggcgacgc cgagcgcgac ggcccgggcg gcggcccagc ccgccaggtg
     7201 ccgggcggcc cgctcctcgg cgtcgatcag ggcgtgcgcg cgcgccgcca cctctccccg
     7261 cgcgccgcac gcgaccacgt cgcgcagccc cgccgccacc gcgccgaact ccgccgacag
     7321 cgtctcgtcg gcgcgcagga aggcacgctg ccgccgggcc atcggcacca gggtcgccac
     7381 gaacagcagc agcccgccgg ccagcggcgg cagcacgatc agcagcaact gcggggccag
     7441 cgacaccagt ccgaccagcg ccccggccgc ggtgaagacg aacgaacgag ccaccaggac
     7501 cagtccggcg aagctgtccc gcgccagttc cgtctggttg gtcagccggg agaccaccgc
     7561 ggtgtcggcc gcgcgggccg ggtccgcgac cgcctcgtcc agcgcccggg ccaccaccgc
     7621 gccgaccagg gcgtcacgca gcggctcgac cagcccggca agtccgcgga agacgccccg
     7681 cccggccaga ccgccgagga cgacggccac cgcggcgacg gccagccagg tcagtccggt
     7741 ggccgtccgg ccggcgagga acccgtcgtc cagggccttg gccacgctgt agccgccgag
     7801 gaaggtgtgc gccgactcca gcagggacca gccgcccatc agcagcagga cccgggcgcg
     7861 cgcccgcagg aagcggagcg cccgcggcag cagccgcacc gtgaccgggg tcatgaggcg
     7921 gtacgcgggt ccggcgcggt gccggcgaac accgcgcggt agtcggcgtc ctgccacagc
     7981 agcgcgtgcg gagcgaccgc gcggatccgg ccgccgtcca tccaggcgac caggtcggcg
     8041 cgggcggccg aggcgaggcg atgggtgatc agcagccggg tgccgggccg gacgtcctcc
     8101 agcagtgccc ggctgacgtg gtgttcggtg acagtgtcca gactggaggt ggcgtcgtcg
     8161 aggatcagca gtcgccccgc gtgcgcgaac gcccgtgcca cgcccaggcg ttgcagctcg
     8221 ccgccggaca gcggggcgtc ggccagggga gtggcgtagc cgcgcggcag caggcgtacg
     8281 aaggtgtcgg cgccggccgc gcgcgccgcg gactcgacgg cgggggcggc gggccgatcc
     8341 ggtccgaagg cgagcgcggc gcccacggtc tcgccgaaca gcgccggccg ctcgaaggcg
     8401 tagccgatct cccggcgcag ctgtgccggg tcggcctccg cgagcgggac cccgtccagc
     8461 agcacctggc cgctgtcggg atcggtgagc cgacccgcga cggcggccag cagggacttt
     8521 ccggcgccgg agtggccgac caccgccagg gtcgtcccgc cgggcaccgc caggtccacg
     8581 ccgcgcagca ccggggcgcc gtcgcgggcg acggtgaccc cgcgcagttc gagccgcccc
     8641 cgcccgtcgg cgggcaacgg gcgggcaccg taccggacct gcggcagggc gagcagttcg
     8701 gcggtgcgcc gggccgcggc gcggccccgg accaacgcgt tgagctggcc ggtcactcct
     8761 cccagggccg cggtgagcgc ggcgtaccgg gaggccgcca gcaactcgcc gacggtgagg
     8821 gcgccgtggg cgagccggag tccgcccacc gcgaggacca cggtggtcag cagcggcacc
     8881 aggatgccgc tgccgacgac cgcccgcccg tagacctgcc acatgagcct gccctgcgcg
     8941 tcgagttcgg gcagcggcgc caggacgcgg gcgcgttccc gcgccccggt gcccgcggcg
     9001 gcgatcgtcc gggccccgcc gagcgcctcg acgagccggg aggcgatctc ggcctggacg
     9061 cgctgatagc gccgtacgca gtcggaggag ccccgggcga aggtccgcag cagacgggtc
     9121 aggaggggca gcccggcgag gaagacggcc gccagccaga cgtcggtcag cgccagcgcc
     9181 accagcgccc ccaccggcgt gagcaccgcg gccaggccgg tggcggcggt ggtgggtgcg
     9241 gtcccggcct ccgcggcgtt gccggtcagc cgggtcacca ggtcgccggc ggtgaagcgg
     9301 tcggcggcgc ggtgcggggc cagcgacagc agatggccga tcccgcgccg gcgcagccag
     9361 gcgatgctgc gggcggtggt gacgcctccg gcgagtgcca ccagggcatc cagcaggacg
     9421 tccgcgacca gcaggacggc actcagggtg agggcggcgc cggcgccggg cgcggagtcg
     9481 aggacgaggt cgagggtgtg gccgaggacg gccggcaggg cgatggccac accggcaccg
     9541 gccacaccga agaggcacac cgcgacggtg tgcacggggc tgtgccggaa ggcgtcggtc
     9601 aggacggccg taccggggtc cggctgccgg ccggtggccg gcgggcgcgt cggtgagggg
     9661 ggcccgggcg gtgcgggcat gcggtggacc tcgcctccgt ggggcgaacg gtgcggggcg
     9721 gcggggcgga gggccccgcg cagccggtgc tgcgcggggc ccctctcacc gtgccgtcgc
     9781 gggactgggg gccccgctgc ggcaggcggt cagttacagg tggtgacgct caggctgctg
     9841 tcaccgcaga ggaggaggct cgcccggctg ccggtgtgca gctcctcggt gccctcgggc
     9901 ttcggggtct ccatcgtctg caggtcgaga agcgacatga tgattccttt cgtaagggga
     9961 cgggagtgct tttcttttac ggccccggac ggggccggct tcagggccgc cgcagcggcg
    10021 ggaggaaggg caggtgcacg ggtgagtcgt gcagcgcgct gcccagagcg agcaggcatc
    10081 cggcggtgcc ggtgctcagg tccatggaga gccgcatcat ctgctccccg gcgaaggcca
    10141 gatggcctcg gtagggaacg gccccccagg agagggactc gatctggcgg tgcaggtcgg
    10201 cggcgtcggt gcccgggccg gtggcggtgg tgcggctcag gtacagcacc atgccggccg
    10261 caccgcggaa caggccgggc tgggcgtaga acttggcctg ggcggcctgg acgatctcgt
    10321 cccgcgccgc cgcgaacgcg tcgtccggcc ggtggacgag gtagtcgtcg agcaccatgc
    10381 cgatgcccac gctgccggcg ccgagatacg gcatggtccg ccagccctcg ttgacctgca
    10441 gggtgccgcc cgcgctccgt acgcaccggg ccaggtcgcg gcgcagcgcc tcggcggcca
    10501 gatccagcag cgcgccgtcg ccggtgcgtt cgtacagccg caggaagagc agcgcggctc
    10561 cgctgtcgcc gtgcagcagc ccggcgcggg acggtgccgt ggtcccgtcg gcgggggcgg
    10621 tgggcggtgc cgcggagcgg agtcggtggg cgaccagctc cgcgcagcgc agcgcctggt
    10681 cccgggcggc gctctccccg gtggacccgg ccagcgcgtc cagcgccagt cccaccccgg
    10741 ccagtccgct gtgcaggtcg ggtgcgatgt cctgccagtc ctgcgcggtg acgagatcga
    10801 cgagatccag ggcccgttcg cggtgcccga gccggtcgag gacccaggcc acaccggaga
    10861 gcccgtcgta gaagcccaac gggctgcccg acgcgggggt cttcgtccgt tgcagcagcc
    10921 attcctcggc gtccggacat cgctcggcgc cggtcgcgtc gagcgcgtac aggacgccgg
    10981 ccgcgccata ggcgaagcag gtcccgccgc ccgccgtggc gaactgggcg atgtcaccgg
    11041 ggaagagccg gtcctcccgc tcgggggtgg ccgaggcgag cacggcccgc accgcgctgt
    11101 ccctgctccg gggccagtcg ccgagcgcga cgggtaagta ggcgtcggtg gagggtggtt
    11161 gggcggacgc cggcgggtgc gggacggggt ggccgcgcag gatctccgtg accgccgcgt
    11221 cgaggaattc ccgtggcacc gggaactgct cagcggcgat ccgcgccaga tgccgggcct
    11281 tgtgccggtc caccgcgaac aggctggtca gcggcaggaa cagggccagc cgcagacagg
    11341 ccagggcgta gcggtcgacg tccgcgccgc gccggtcggc gggggcgacg aagccggggt
    11401 tggcgatcac ctgccggctg gccgggtcgt cgacggaggc ggcttcgaag tccagcagca
    11461 ccaccgagga ctcgtcctcg gacagcatga tgttgaacag atgcaggtcg ttgaagacca
    11521 cgccccgcgc gtggatcgcc tcgacggcct cctccacgag ccggtggacg cgcagcgccc
    11581 actgcgtgta ctcggccagc cgctccgcgg acggatcggc ctcgatcagc ggatggcggt
    11641 gcgcgaagaa gctgttgagc ggccggccct cgatgtactc cagcaccagg aaggtgtgct
    11701 ccccgagcgt gaaccagtcc aggacctcgg gggcgcagcc cagcccggac agccgccgca
    11761 gggcgtcccg ttcacgcgcc agccgcgtca cggcgtccgc tccgtccgcg gccaggccgg
    11821 cgtgcggacg cccctccttg agcaccaccc ggcgctcggt ccgcaggtcc cggccgacgt
    11881 agacaccgcc gccgttggag aagtgcaggg cccgctctat cgcgtacggc aggtcggaga
    11941 ccgtggtggc ggagcgggcg tccaggtggg gcttgaggaa gtccgggagg tcgacccact
    12001 ccgggacccg gaacgcgggt tcccggcggt cggggaccag ccgtccccgg tcgtcctcga
    12061 tcgcggggca gagttcgccc ttgtcgtcgt agcagtgccg ctcggtgaag ctgccgtagc
    12121 gcacgtacac cgggccggtg ccccagcgca gatcgctgag gatgtacgga ccggactcgc
    12181 cggccagcag ggcgttcagc tcctcggcga tgacgcggca ctgttccgcg tcggccgggt
    12241 agacggtgac gaacttcccg ctggcgcccc ggtcggtgta cttggcgttg cgtatgtgca
    12301 gcagatagcg gctcggcatg cacttgaacg ccaccgagcg ggggacgcag tagtcccaga
    12361 ccttctccag gatccgctcg gcattgtcca ggcaggcgga gacatgtatt ttccagccct
    12421 ggctgggcag ttcccggtcc agtggacgga acgccagcca gtcacccgac cggtggcgct
    12481 gccagccgcc gggcaactcc cggcgcagta cggggtacag ggcgccgcgg ccctccttgt
    12541 ccgagggaag gcggtgcgga gcgtcgtaga actgccggtc tgcgtcgcag aagaccgcgt
    12601 accccttgtt catcgcactc cctcggccgg tgacgtgacc acgctgtcac ggcgcggagg
    12661 ggtgaaacag tcatggatgt cacgacgagg tcgtgaagaa tgcacgtttt atgtaaaggg
    12721 gcggcgggct cggaaggggc cgccgcgggg atgcgccgcc ggtgcgcacc gcgggccggg
    12781 gcggagacgg cgatggcccg gcgggaggat ccgccgggcc atcgcctcag tctctgcatg
    12841 cacggtcgca gctgccgaag tggctgcggg gcgccctcat cgcttcaggg cgtcctgggc
    12901 cttgtggccg gcctgccgca tatcgccctt ggcgcgctcc gcgcgtcctt cggcggtcat
    12961 ccgctcgttg cccaccgcgc gcccgagggt ttccttcacg gcgcccttga gctggtcggc
    13021 cttggcggac gtcttcttct cggcggtcat ggtcgtgctc ccttgctgtt gagccgttcc
    13081 ttgacaaaga tccgcctgcc cggggcgaca ccgcacaaac ccgcccgccg cccggcgccc
    13141 cgtcggcgtc ctgctgccgt ccggcacccg ccgatgagcc ggggcctgac gaataaccag
    13201 atgcgggcca ccggggatgc tgccaggctg cgccggtgaa tcgcgaacag atgtcccgca
    13261 tcgcccactc cgggcacccg atcaaggctc cgctcgacga cgcatccgtg cgccggttgc
    13321 tggaacgcgg cacaccgcgc ggcgacgagc ggctgctcga cctcggctgc ggcagcgccg
    13381 aatggctgct gcgcgccttg gccaccggcc cccaactgca cgccgtggga gtggacatct
    13441 ccgacgacgc gctgacgcag gcccgggagg cggccgatcg ccgcggcctc ggggagcgcc
    13501 tcgtcctcca ccacggagcg gccgcggact tcgtctcccc ggacccgttc gacctggtgc
    13561 tcagcgtcgg ggccgcgcat gccttcggcg gtctgctgcc cacgctcgcc gcggcccgcg
    13621 cgcacctggc gcccggcggt caggtcctga tcggtgacgg gttctgggaa cacccgccgt
    13681 cgccggaagc cgtcgagatg ctcggggact tcaccgacct ggcgagcacc gtggaccgcg
    13741 tcgtcgccga cggctggacc cccgtccacg ggcacgtgag ctcgcgacag gagctggacg
    13801 cctacgaatg ggcctgctgg gggaccctgg ccgcgtgggg cctggaccgt cccaccgacc
    13861 cggacggccc acgggcgctg gcgatggccg ccacccggcg ctccgagtgg ctgcggagct
    13921 accgcgacac ctggggtttc gtcaccctgc tcctccgccg gacggccgac tgaccgaccc
    13981 cgcggcacgc gccccgggga gtaggggccg ccatcgatgc ggccctcccc ggcggcgcgg
    14041 cagtggcggc agaccgcggt ccgcatgccc gccccgccgt ccgcgggcac gtcagcccgt
    14101 ggtgaggacc atccggaagc gggcggcgcc ggacagcatc ttccggtacg cctcgtcggc
    14161 ccggtcgagc ggcacggtct cgatcatcgg gcggatcccg tgcagggcac tgaacgccat
    14221 ggtctcctgc acgtcctgcg cggtgccgga cggatggccg cggacgacct tgccctgcat
    14281 gagcagctgg gcggggctga tccccagggg tgcggtgtcc gcaccgacga cgatcagctc
    14341 accccgcggc gacagcccct ccaccgtgga ggtgatggcc tgcgagttgg cggcggtggc
    14401 cagtacggcc ttggcgccgc cgagcgcctg cagggcgtcc gcgacggggg tgccggccgt
    14461 ggtgtcgatg tagtggtgcg cgccgagttg ccgggcgaag tccgccttgt cggcgccgcg
    14521 ggcgagggcc acggtctcga agcccatggc ggccgcgtac tgcacaccca ggtggccgag
    14581 gccgccgatg ccgaggacgg cgaccaggtc gcccggtcgc gcggagctgc gccgcagacc
    14641 gttgaacgtg gtcacgccgg cgcaggccat cggccccgcc tcggtggccg ggaccgtgtc
    14701 ggggatgcgg gccagggcgt cggccggtgc gatcaccgtc tcgccgaacc cgccgtcgta
    14761 cgcccagccg gggaccttca ggttctcgca cacgacgaag tcgccccggc ggcagggtgt
    14821 gcaggagtgg cagctgccgc cgaaccagcc caccaccacc cggtcgccca cctgccagtc
    14881 gcccggcgtc gccgcgccga tctcgtcgat gcggccggcg atctcgtgcc cggggaccag
    14941 cgggaaccgc acgcccggca gcacggcctc gacgaagagg gcgtcactgt ggcagatccc
    15001 gcacgcctcc accgccagcc gtacctgacc ggcgcccggc cgcggcacct cccgctcgac
    15061 gacctcgaac gacccgcccg cggcggcgac ctgcgcgact cgataggcgc tcatctggac
    15121 ctctcccggg tgcacgacga tcccccgacc cagcagacca gttccggtcc gaggacgcgc
    15181 gccgggcggg acggaccggc acccggccga tgtcgtccgc ccaccgcacg ggggcggacc
    15241 cggccggacc ctccggcacc gcggcccgcc cgccccggct ccgccgaccg ggtgacaggt
    15301 gccgggggca cgggcggtgc cggaggcccg aacggcggcg ggccgaccgc cggcggtgcg
    15361 gccggcccgt ggccgtcacc ggtgctcggg gccggcccag gcgacgagct ggaggatgac
    15421 accgttcggg tcggtgacct ggaagaggcg ttcgccccac ggctcctcac gcagcggcat
    15481 ggtgatgggg gcgccctcgc tgctgagccg ctcgaactcg gcgtccagat cggccacggt
    15541 gaacgcgatg atcacgccgg cggcacgctg gtcccggaag ccttcgggca ggacctcgat
    15601 gccgcgccgg agaaagatca cgttgggcgc gtcctcgcgg gccagcgagg cgaagccgtc
    15661 ggcggccatg gcttcttgga agccgaagtg cttgaccagg aatgcggcgg aggcgggaac
    15721 gtcgtcaacg gtcagggaga gggcgctgga ggtgatgttc atgacctgct cctgggctgg
    15781 gggatatctc tgtacgtcgt acattgtacc gcgtatagag ttttacggga gggggcgagg
    15841 aactcagcag gaagaatggg gcccatggcc aaggaacaca ggggcacgag cgatccggcc
    15901 cgcatcctgg aactgctgtg gcgcgaaccc ggacacgggg attcccgccg cggcccgaag
    15961 cagggtctga cggtcgacgc cgtcgtccgg gtcgccgtcg aactcgccga cgccgacggc
    16021 ctggaggccc tgaccatgcg cggcatcgcc cagcggttgg gcgtgacgcc gatgacgctc
    16081 tacacctacg tcccgggcaa gacggaactg ctcgacctca tgctggacgc cgtgtacctg
    16141 cagatgccgc gcagcgaccg atcggcggat ccgtggcgca cgagggtggc ggcggtcgcg
    16201 gacgagaacc gcgccctgta cgaccgccac ccctgggtgg cgaccgtgct caccgcgcgt
    16261 ccgccgctgg gtcccggcct catgaccaag tacgaacacg aactggccgc cttcgacggc
    16321 ctggggctcg acgacgtgga gagggacgcg gcgctcactc tcgttctgga cttcgtccag
    16381 tccgtcgccc gtggaaacct tgccgcccgg gccgccgccc gcgacagcgc gatgtccgac
    16441 cagcagtggt gggccgccaa cgcaccactc ctggccaagg tcttcgatcc cgaccggttc
    16501 cccctggctg cccgtgtcgg aagcgccgcg ggcgccgctc accagggcat gtacagccct
    16561 gaccatgcct tcgacttcgg actgcggtgc atcctggacg gtctcgccca cctggccggt
    16621 tgcgaggatt ccgcggacac cccgtagccg gtcacgcgtc cgcaggtcac cgtccgccga
    16681 acccccgggc cctcggccgg gccggcgatc cgctcagcgg gtggcctcca ccaactgcgc
    16741 gtactccttg ccgagttgcg acatggcgtg cgcgaactcc ttctgcgaga cggcttcctg
    16801 gagggtgctg aggaccgccc ggacgccccg ggcggcctcc ggctcggtca gcccggtgtg
    16861 cacgcccacc ctgcggatcg actcggcggg gccgaagatc tccatctccc cctgtccggc
    16921 ctggagcgag ccacgcagcg gctcgggaag ttcgagggcc agatcgcggg cttcgccgcc
    16981 gctcagacgg tgcccgagcg tgtcgagggt ggcacgggtg agatcggccg cttcctgtcg
    17041 ggagagtccc gagcgctccg ccaccgcgcg gaagaactcc ttgtcgtcca tgtgggcctc
    17101 ctctgcggaa tcgggatggg cgagggaggc aacctcaccc accaccttgc cacgcccccc
    17161 tcccgcgtgc gaggcgccgc gacggcggcc gcacccgctc cgcctgcggt tgtgcactgg
    17221 tccagtccaa agtgttgacg cgtacgcgac gagcgatcag gctgtgggtg attggtctgg
    17281 accactttcg ccccgcggga gggcatgtgc cacctcgaaa cgtcagaacc ttcgccgccg
    17341 tcgcctcggc ggcctgcctc gcactggtgg cggccggtac ggccctcgcc accggccacg
    17401 gtgccgccgc tccggcccgg gaggccgtgg gcagcaactg gtacgcggcg gcgccctacc
    17461 tcatgccgct cgacaacgac ccgccggacg cagcggccgt catggacgcc accggcctca
    17521 aggcgttcca gctcgccttc ctgctggccc cgaacggcgg cggctgttcg ccgacgtggg
    17581 gcggcaccgg tccggtctcc tcggacaccg cggtggccgg tgtgatcgcc acgatccgcg
    17641 cgaagggcgg cgacgtgtcg gcctccgtcg gcggctacgg cggcaccaag ctcggccaga
    17701 cgtgcggcac ccccgaggcg accgccgccg cgtaccagca ggccatcgac aagtacggcc
    17761 tcaaggcact cgacttcgac ctggaggagc cggagtacga gaacgccgcg gccatccaca
    17821 acgagatcgg cgccgccaag atccttcagc agaagaaccc cggcatctac ctctccgtca
    17881 ccacggccgg caccgccgac ggcaccggct ggttcggcaa gcagatgctc aacgaggcga
    17941 aggcccagtc cttcaccccg gacaacttct ccatcatgcc cttcgacggg ggcttcaacg
    18001 gcgcggcgtc gcagaccgcg gcgctgacca acttcaactc cgtcctgcgg tccaccttcg
    18061 gctgggacga ggccaccgcg tacgcccacg agggcatctc gcagatgaac ggccgcagcg
    18121 acaccgggga gtacttcacc caggcggact tccagacggt gctggacttc gccaccgccc
    18181 accacctggc gcgcttcacg aactggtccg tcaaccgcga ccggcagtgc tccccgccgg
    18241 acaacaacgg caagacgtcc ggtacctgca gcagcgttcc gcagggcgcc tacgacttca
    18301 ccaagtactc ggtgaggttc gccggggcga cgccgcccac cacaccaccc accaccccgc
    18361 ccacgacacc gccgggcaac ggcggctgca ccgcggccgc ttacggcgcc ggcaccgtct
    18421 acgtgggcgg tgacacggtc tcctaccagg gccacacctg gcgggccaga tggtggacgc
    18481 agggcgaggc gccctccacc ggcggctcgg gagtctggca ggacctgggc gcctgctgac
    18541 cggcgagcgg gggtcgtccc gtcgggaagg cccccgggcg gcacacgtac gcgcgtcccg
    18601 gtaccggcgg tgaggccggt accgggacgc gctgcgccgg ggcgttaccg caggtgctag
    18661 ttcacgttca gaccggtcca ggcggcgccg accgccttgt actcggtgcc cgtggtgccg
    18721 tacagatcac ccgccgcctt gagggtcgcc gtgcgggcgg ccttgtagtt ggtggtggag
    18781 gtcatgtacg tggtgagggc cttgtaccag atcttctcgg ccttgtcccg gccgatgccg
    18841 gtgagcttgg agccgttgta ggtcgggctg ttgtagctga cgccgccgat gaccttggcg
    18901 ccgctgccct cggacagcag gtagaagaag tggttggcga cgccggacga gtagtggacg
    18961 tccttgttgc cgacggtgct ggaccagtag tcggccgagg cgccgtcctt gctcggcttg
    19021 tccatgtagc gcagcggggt gccgtcgccg ttgatgtcga tcttctcgcc gatgaggtag
    19081 tcgcccgggt ccgaggagtt gttggcgtag aactcggccg aggtgccgaa gatgtcggac
    19141 gtcgcctcgt tcagaccacc ggactcgccg ctgtagttga ggccggcggt ggccgccgtg
    19201 acgccgtggc tcatctcgtg ggcagccacg tcgagcgagg tcagcgggtg ggtgttgccg
    19261 ctgccgtcgc cgtaggtcat gcagaagcag ccgtcgtccc agaaggcgtt gacgtagctg
    19321 ttgccgtagt ggacgcggga gtaggcgccc ttgccgtcgc cgcggatgcc gttgcggccg
    19381 aaggtgttct tgtagaagtc ccaggtgacg gccgccccgt agtgcgcgtc gacgccggcg
    19441 gtctggcgcc cgccgcccca aacgtcgtcc gcgtcggtga agagcgtgcc ggtgccggac
    19501 gtcttctggt tgaggtcgta cgtcttgtga ccgccgcggg ccccgtcggt gagctggtag
    19561 gtcgttccgc tcttggtggt ggtgagcgcg accttgccgc tgtaggtgct ggtaccggtg
    19621 ccggtctcga tggcctcgtt ctgccacagc ttcttgccgg tggcggcgtc ggtgatgacg
    19681 tgcagccggc tgggcgtgcc gtccttctgg acaccggtga cgacggtttc gtaggcgagg
    19741 accggcttgc cggtggccgc ccagatcacc ttgcgcggcg tgccggaggc gtctgtcttg
    19801 ctgtccttca ccgcggcggc ggcgcgcagg gcgctcttcc gcgcggcgga gggggcgagc
    19861 ggggcggccg tactggccac ggatatacgg gcgttggtcg ccttggtgac gctgtgcgca
    19921 ccgttcttgg cctggtgcac gacgaggtcg ccgccgagga cgggcaggcc gtcgaaggtg
    19981 cgctcgtacc gggtgtgcac cgtgccgtcc gcgtccttga tgacgtcccg gacgacgagc
    20041 ttctcgcgtg cgccgaggcc gatcttcgcg gcggtcgcgg aggcgtcgct ctgggcgctc
    20101 ttgagcgcgg tggcccgctg agcggcggag agctggaccg ccgacgcgcc ggtcgcacgg
    20161 tccggctgcg cgctggccga tccggcctgg acgccgacgg cgaccatggc ggccgaggcg
    20221 acgagggcgg cagcgcgcag ggtgttcttg cggggggtgg acgagatccg tctcaactcg
    20281 gtctcccttg tgtgggccgc ggggtcgcgg tcccaagaag cggccgggca gccgaggggt
    20341 ggggtgcccg gtggagcaag agtgaatcga ggggagactg ccatgagttg atgctttttg
    20401 acagatgttc aacatccaag aaacaaaaaa ttcacggatt caaccgcttc gtaacgagga
    20461 tgtccgaacg gcatgcgaaa ggcgcccatg gggctgcccc ctccctgcac agctctccca
    20521 cccgccccaa gaagggactc cgtactttcc gcaaaattcc ctatcgcccc tccagtaggg
    20581 gaagttaggg tacgttcgtg aacgagcact tctactcggt ggagcaggtc gccgagcacc
    20641 tcggcctgca tgtccgcacc gtccgcaact acgtccgcga cgggcggctc cccgccgtcc
    20701 gcatcggcaa gcagtaccgg atcgcgcacg aggacctgga agccttcacc ggccgtccgg
    20761 ccccctctcc ggggagccgg gccggcggac ggccaccgca cgccgaggtg tcgagcatcg
    20821 tgcagatcga cgcggtcgac gccgggacgg ccggtcgcct ggccggcctc ctgatgagcg
    20881 cggctgccca cggccgtccc ggcggggcgc cgttgcggat cgagacggcc cacgacccgg
    20941 agcgggcgcg tatgaaggtc atcgtcctgg ggagcccggg ggacaccgcc cggctgttgg
    21001 agtacatgga gggggtactc gcgtcatgag cgcgatctac aagtccgagg cgggcgcgca
    21061 ggagatacag cggcggtacc gcgaggcgct ggacgcctgg ccggtccccg cggagcagct
    21121 gcgggtaccc acccgcgagg gcgagacctt cgtgctggtc tccgggcccg aggacgcgcc
    21181 gcccgtggtg ctgctgcacg gcgcgggggc gaacgccacg atgtggcagg acgacatcac
    21241 cacctgggcc cggcacttcc gcacctacgc cgtcgacctc atcggcgagc cggggctgag
    21301 cgcaccgtcc cgccccccgc tcgcctcgga cgccccggcc cggtggctgg acgacgtact
    21361 ggaggccctc gggatcaccc gcgccgcgtt cgtcgggacc tccctcggcg gctggctggc
    21421 gctggaccac gccacccggc gcccggaacg ggtggaccgc ctggccctgt tgtgccccgg
    21481 tggcgtgggg cggcagagga tggggtggct tttcaaggcc ctgctgctgc gccccctggg
    21541 ggcccggggg gtgcgccggt cggccggtgc cgtcgccggc ctggaccggc cggagcaccg
    21601 ggccgtcctc gaccaactcg tgctgacctt cgcgcagttc aagccgcgca ccgagcggct
    21661 gccggtgttc cccgacgacg cgctgcgccg cctggccatg cccgtccagg tgaccgtcgg
    21721 cggccgtgac gccctgttcg actccgcggg caccgcccgc cgcaccgccc gctgcgtccc
    21781 gcacgcgacc gtgcgcgtcc tgcccgaggc cggacacgcg ctcctcgggc agaccgatgc
    21841 cgtactgacc tttctccgcc actgacatga aggaggtgtg ggccgcgatg cccacgaccg
    21901 agatgctggg ccggatcgcc acgtccacgg accgcttcgt gcggaccgtc accacgctca
    21961 ccgatgcgga catccgcgga gcgacgctgg tgccgccgtg gacccgcggc catgtgatca
    22021 cccatgtggc acgggccgcc gacagcctct gccggctcct cacctgggcc cgcaccggtg
    22081 tggagacacc gcagtacacc gggatggacg cccgggccgc ggagatcgag gccggcgccc
    22141 ggcgcccggt cgacgcgctg gtggccgacg tcctggcgag cgccgcgcgc ttcgacgacg
    22201 ccgtgcgctc cctgcccgac gcggcgtgga cctacgaagt ccgcatgcgc accggcgaac
    22261 cgcgcacacc ggccgccctg atggtctccc ggcttcgcga actggaggtg caccacgccg
    22321 acttggcgac cggctacacc ttcgccgaca taccgccgga ggccgcccgc tggatcatcg
    22381 acgacctcgt cgaggcgcag cgccggcgcg acggcacccc accgctgcgc atcgaggcca
    22441 cggacaccgg cctgtcccgc gaactgggca gcgggggtcc gacggtccgg ggctcccagg
    22501 cggacctcct cggctggctc accggccgca ccggcggagc caccctgacg accaccgccc
    22561 ccggcccggt ccccgacgcc ccgtactgga tctgaacggc accctccgca cgc
//
