LOCUS       NZ_CP017157            22682 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces lydicus strain 103 chromosome, complete genome.
ACCESSION   NZ_CP017157
VERSION     NZ_CP017157.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lydicus
  ORGANISM  Streptomyces lydicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Complete genome sequencing of Streptomyces lydicus 103 and metabolic
            pathways analysis of antibiotic biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8201357)
  AUTHORS   Jia,N., Ding,M.-Z., Gao,F. and Yuan,Y.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2016) Key Laboratory of Systems Bioengineering
            (Ministry of Education), Tianjin University, Tianjin 300072, PR
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 100x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001729485.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:23:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,288
            CDSs (total)                      :: 7,195
            Genes (coding)                    :: 7,061
            CDSs (with protein)               :: 7,061
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 134
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 47 of 134
            Pseudo Genes (incomplete)         :: 104 of 134
            Pseudo Genes (internal stop)      :: 11 of 134
            Pseudo Genes (multiple problems)  :: 26 of 134
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:52:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 153486
            Orig. end                         :: 176168
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017157.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Source DNA is available from Prof. Ying-Jin Yuan.
            Annotation modified by submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22682
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22682
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22682
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12682](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12682
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(653..668)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.72"
                     /tool="antismash"
     misc_feature    797..806
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.55"
                     /tool="antismash"
     misc_feature    797..811
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.24"
                     /tool="antismash"
     misc_feature    complement(968..981)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.72"
                     /tool="antismash"
     misc_feature    971..984
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.73"
                     /tool="antismash"
     misc_feature    973..989
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.5"
                     /tool="antismash"
     misc_feature    complement(973..989)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     misc_feature    complement(975..990)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            1036..2277
                     /locus_tag="SL103_RS00670"
                     /old_locus_tag="SL103_00670"
     CDS             1036..2277
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981569.1"
                     /locus_tag="SL103_RS00670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00670"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_069566845.1"
                     /sec_met_domain="Aldedh (E-value: 2.6e-24, bitscore: 84.3,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSAPAWPTVAAEPEGSLARHRAAAVHRVRDFLVNDAGTVHELLC
                     EISTHRAARYEIESTVATLDGALDEVTAHRPGRVPRLAAFMPSNVILYSYALYLLVPAL
                     YTDRLVFRPSSRVKDQMRRLHTLLAAQHGLPIELTTASQRDFLHDHVLPADVVVFTGAY
                     ANAEQIRARLSPGQLFLFLGSGVNPFVVAPGADVERAARDAIAIRVLNTGQDCLGPDLF
                     SVHETLLEPFVDALVSELKGLRYGPYTDPDADFGPIFYDSALEDGAQFLARHRGAIVHG
                     GHVDFRGRRLDPTVVVGEEVTPRTHVPEFFAPIFNVASYRDEDALATTLTTGMFTERAL
                     GSSVYGHAPRLVEALRRRTTVTLDTTLLSIDDGNAPFGGYGRMANYISDGHELRAEPVL
                     LSKAVAAHRPGAAR"
     gene            2274..3983
                     /locus_tag="SL103_RS00675"
                     /old_locus_tag="SL103_00675"
     CDS             2274..3983
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981568.1"
                     /locus_tag="SL103_RS00675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00675"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_069566846.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-44, bitscore:
                     150.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-16, bitscore:
                     59.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTHPTAWAALADYLRHLGTGAVFGLPGDDMALLGELERADTP
                     VVLCRDQRNALFMATGYALAAGRPGVCVIGKGPALTNALTGVLEARSAAAPLILIADGT
                     RLDRLGTGAFQELDQLTAVRPYVKWAARIDHADRLPAALEKAAALAVNGTPGPVYLELA
                     EQLADQPVTRSGSWRPVAPQRPSPDQDALAATAERIAAAERPLLLVGGGARHRNTGRRI
                     ERLAERLGAGVFTTASGRGAVAEDHPLYCGVSGLYTVAPMDALWREADLVIALGSRLEE
                     TATFGWPEDAAQLPVVQAVLGEESLVMERPGAHVLGDAGRIVDGWAELLAGHRATGDWP
                     ERIRTARTALAQRAADRAEEAVKRVPEGAVPVSQVLAALDRAVPAGRVLVQENGLQDMW
                     SYFFPHYALGTGGGSVVPSEQTPLGFGAAAAVGVRLAEPAGRPVVAVVGDGAFNLFRCE
                     LPTVADAGAAVLYLVLDNGGYGWLQSNLDRVSGPASRFSFTTPRPTGTEGVSLAHGLGY
                     ARVTNAEDLPAALSAAWQRVASGTTSIVEIAVALPDTPPGMTAASGDFPERE"
     gene            complement(4246..4998)
                     /locus_tag="SL103_RS00680"
                     /old_locus_tag="SL103_00680"
     CDS             complement(4246..4998)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358668.1"
                     /locus_tag="SL103_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00680"
                     /product="ABC transporter permease"
                     /protein_id="WP_069573228.1"
                     /transl_table=11
                     /translation="MARHTGALVRRNLLQIRQNPESMTDALLMPIVLTVLFVFVFGGAV
                     GGSRARYTAFLVPGLMVILGMTIAMAVGTGVNDDFRTGVMDRFRTMPIARSSVLLAKVV
                     VETGRMLVAIAVLLLVAAVLGFDFTGRWPGIAAAVGLTTVFGTSLIWIFMLLGLTLRSA
                     QAIQGLSVLVLTPLQFGSSIFVSPTTMPDWLRAFTRVNPLTHMADAARGLALGEGPVAG
                     PVLWTLAWSLALTAVTAPLAIAKFRAKS"
     gene            complement(5073..5729)
                     /locus_tag="SL103_RS00685"
                     /old_locus_tag="SL103_00685"
     CDS             complement(5073..5729)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021443.4"
                     /locus_tag="SL103_RS00685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00685"
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_164492739.1"
                     /transl_table=11
                     /translation="MTQPQRPDLHKDLAPPSVSSRSVLASDAEREDMVERLREATAEGR
                     LTLEELAERSEAAYLARTREELSSVGEDLPHVTAPESARTATGQRSFRAAFGDVTHHSP
                     SLEHGIEATAIFGDLTLDLCASPAPSTGELTIQARAIIGDIHLLLPEGVRVEMNCSTVL
                     GDVRNLIREHSGPEAVTPRVRITGSAVFGDIIVAHPSSDRRTYWQRWLDERRGRA"
     misc_feature    5956..5971
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     misc_feature    complement(5967..5982)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.8"
                     /tool="antismash"
     misc_feature    6061..6076
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.44"
                     /tool="antismash"
     gene            6065..7312
                     /locus_tag="SL103_RS00690"
                     /old_locus_tag="SL103_00690"
     CDS             6065..7312
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="SL103_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00690"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_079145488.1"
                     /transl_table=11
                     /translation="MPELADTGRRIKELRVSAGMTQHDLAGSEMSSSYISLVERGKRIP
                     SGRALRILAERLGVGVDEISRGAEPVETPGRVRRLDLVGRLVAARRQWEGGDAEGALSE
                     FRALAETDPAGRQDDVFTEAQLAIAEILGTLGRADEGAEVLLRMLDALAPAPYAEARLR
                     ALIALADLLESAGRVQDGLRYALTGFLECADRSPGSGFHALLVLEVLTRCAYWSGCPDW
                     APGTDHGRPSADGVLPGPRATIDLHRALDLRDRGEVARAAELLGECARRVTPAAGFPLW
                     EKISGHYALLLLERGEAAAARSIVERGLVVASVAQEPDFPLWLSTAQAVCAQAAGDADR
                     LFALGEEVAALPDTGRSHEKAAALGEIAAACERAGDRERAAGHFRYSAELFRRAQAYRH
                     AERARERLADLLEKRG"
     gene            complement(7371..7550)
                     /locus_tag="SL103_RS00695"
                     /old_locus_tag="SL103_00695"
     CDS             complement(7371..7550)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538451.1"
                     /locus_tag="SL103_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00695"
                     /product="DUF5708 family protein"
                     /protein_id="WP_033267993.1"
                     /transl_table=11
                     /translation="MKGIAVGIVLAIVGLILWLTTKEVETPVVSLHKAGLVLAIVGGAE
                     ALFALLGLGKKANK"
     misc_feature    complement(7785..7799)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.38"
                     /tool="antismash"
     misc_feature    complement(7815..7826)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.94"
                     /tool="antismash"
     gene            7982..9241
                     /locus_tag="SL103_RS00700"
                     /old_locus_tag="SL103_00700"
     CDS             7982..9241
                     /EC_number="2.3.1.179"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (9-416). E-value:
                     5.9e-59. Score: 192.0. Matches aSDomain:
                     nrpspksdomains_SL103_RS00700_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578549.1"
                     /locus_tag="SL103_RS00700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00700"
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="WP_069573232.1"
                     /sec_met_domain="t2fas (E-value: 2.7e-144, bitscore: 479.6,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.3e-52, bitscore:
                     176.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELRTDRRRVVVTGCGVVSPVGNTTADFWNALLDGRSGIRAVTRF
                     DTYGLPVRIGGDLTGFDTTGCLTPQEARRSDNFTQYAVVAAVQAMRAAGLATPAGIDPH
                     RFAVVIGSGYGAAIAIQQQYDVLREHGPRRVSPYHSVLTAIDHPAGLLSIKYGISGPSC
                     AVSAACATGAVAIGEAVEMIRHGRADLALAGGTDDSLTAVDLAGTANAQALSRRNDDPE
                     GASRPFDRDRDGFVMSVGATVLTLEEAGHAERRGAEILAEVAGYAATTDAHHATAPDPT
                     GAGAIRAMRGALADAGCVPEDVGQVSAHGTGTVLNDRIEAAALREVLGPDQLRRTPITA
                     VKSMTGHMLGASGAAEAAAAVLSLRDHVIPPVRNCDHPEEEDLDLVVKGAREWDGDVVL
                     SNSFGFGGHNAVLVLKRWTR"
     aSDomain        8009..9229
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: False"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS00700_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.90E-59"
                     /label="SL103_RS00700_PKS_KS.1"
                     /locus_tag="SL103_RS00700"
                     /protein_end="416"
                     /protein_start="9"
                     /score="192.0"
                     /tool="antismash"
                     /translation="VVVTGCGVVSPVGNTTADFWNALLDGRSGIRAVTRFDTYGLPVRI
                     GGDLTGFDTTGCLTPQEARRSDNFTQYAVVAAVQAMRAAGLATPAGIDPHRFAVVIGSG
                     YGAAIAIQQQYDVLREHGPRRVSPYHSVLTAIDHPAGLLSIKYGISGPSCAVSAACATG
                     AVAIGEAVEMIRHGRADLALAGGTDDSLTAVDLAGTANAQALSRRNDDPEGASRPFDRD
                     RDGFVMSVGATVLTLEEAGHAERRGAEILAEVAGYAATTDAHHATAPDPTGAGAIRAMR
                     GALADAGCVPEDVGQVSAHGTGTVLNDRIEAAALREVLGPDQLRRTPITAVKSMTGHML
                     GASGAAEAAAAVLSLRDHVIPPVRNCDHPEEEDLDLVVKGAREWDGDVVLSNSFGFGGH
                     NAVLVLKR"
     CDS_motif       8459..8506
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SL103_RS00700_0001"
                     /evalue="3.70E-02"
                     /label="PKSI-KS_m3"
                     /locus_tag="SL103_RS00700"
                     /protein_end="175"
                     /protein_start="159"
                     /score="7.1"
                     /tool="antismash"
                     /translation="GPSCAVSAACATGAVA"
     gene            9273..10004
                     /locus_tag="SL103_RS00705"
                     /old_locus_tag="SL103_00705"
     CDS             9273..10004
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="SL103_RS00705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00705"
                     /product="GNAT family protein"
                     /protein_id="WP_079145489.1"
                     /transl_table=11
                     /translation="MQGRLVTLEWPGDDDWAAIASWLRPGSPAAVLSGDWELLGAAEVE
                     QANRSGRVHNLVIRAKDGERIGTVSYQRSGRIGGYTVGGAIGSPELWRRGYGAEAVVLL
                     VDYLFHQLDAHKVQVTTAGYNKGIIRLMTKTQFVVEGILRDHCYLDGEYHDAIVWGLLR
                     DEHYASLKPSDDNRVLAVGLADFVPEDDKTQARAVLAEHLASTGRTALAPYLDGAAPRP
                     AAVPADPSDAAGRAEPARGAA"
     gene            10001..12682
                     /gene="lanKC"
                     /locus_tag="SL103_RS00710"
                     /old_locus_tag="SL103_00710"
     CDS             10001..12682
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="SL103_RS00710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00710"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_069566848.1"
                     /sec_met_domain="micKC (E-value: 2.5e-231, bitscore: 768.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.4e-08, bitscore:
                     31.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDGAESFALADRTFFDWPGNWDLEATRFPAPPLPDGWTHDENEA
                     WAFCRPPEDRLPDQGWKIHVSAAPDDAARTIADVAAYCTRHGLTFKYLKSANVLRALSR
                     KYAQRSSAGKLLTVYPVDEADLARTLEGLDALVGGRPGPYVLTDLRFREGPLYVRYGGF
                     RTHYTEDADGELVTAFHRPDGTPEPDRRTPVFHTPDWVTVPDVLKESLAARQALDDFPY
                     RITGALQFSNGGGVYRAAPLGTDALGAGETGVVLKEGRPWSGTDGVGRDAVTRLAHEHR
                     MLQRLAGLPGIPRTFGTLQVRDHLFLVLEDIEGQDFQTWLAAHHPLTVPDPDEQAVADY
                     RDRALALFGRIEALVAAVHGRGVRIGDLHPGNLIIKPGDEPVLLDFEVADEIDRATPSS
                     LGAPGFHRADATGADGDRYALAAIGLWLFLPLAALGGLAPDKAPALLATAAERYALPDA
                     LVARLAPQLAPNDDTTSELRSLPGTFPPSDVLASLGRGLRESATPHRADRLHPGDFEQF
                     VEGGAGFGHGAAGVLWARHTVLGERDEEGAAWLRAAVDRVPAERIGFYDGLHGMAYVLQ
                     ELGDDEAAQRALDRAADRLPVRHCPSLYRGLSGVGLNLLHFADALDRPDLRKQALDLAG
                     RVTERLAAARTEPVERRRRRGAQDAAGLMYGWSGAALFLLRAHQATGDPGLLDQAVLAV
                     HRDLDRCSPGPQDTLQVDEGFRLLPYLDNGSAGIALVAAALLDHRDDDRIHQALPALLR
                     ACAADFVIESGLLGGRAGLLATLAALRERAALPPERTDRYLRRHLTNLGQHAMTRNGAV
                     VFPCDGRARISMDLAGGGAGVLLALSTTERGTPLLPFLTDSRPAAAVHPAAPGRVGGAH
                     GAVTPTAPSGAAGTAHHGREVS"
     misc_feature    11723..11725
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13114..13209
                     /locus_tag="SL103_RS38280"
     CDS             13114..13209
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS38280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="class III lanthipeptide"
                     /protein_id="WP_208869784.1"
                     /transl_table=11
                     /translation="MSTMTIMDLQGLEVPGERDAQALGSTISGGC"
     misc_feature    complement(13119..13134)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.69"
                     /tool="antismash"
     misc_feature    13258..13267
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     gene            13328..15157
                     /locus_tag="SL103_RS00715"
                     /old_locus_tag="SL103_00715"
     CDS             13328..15157
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024846.4"
                     /locus_tag="SL103_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00715"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_069566849.1"
                     /transl_table=11
                     /translation="MNRQVGPARSLCVIGCGPRGTSIVERILANVPALYGDRPLDLHVV
                     DPYPPGAGRTWRTDQPGLLWMNSAAEQVTLYPDASVDCAGPPRPGPTTAGWLDAPLHDG
                     AYAARRDQGRYLRHFFDTVTRELPATVRLYVHRARAVDLRRVTADGLPPAPGDTPAGRQ
                     QVVLDSGEAPFLADRVVLAQGHLETRTDPAPPGLTRIGPGPADPDALAAVPPGEPVLVR
                     GLGLVFIDCLALLTEGRGGRFVRTAPGGPLRYLPSGREPRLYAGSRRGVPLPPKPARGA
                     PDAPAAAPAAPRFATLDACRARLARPAAAFGRDVWPLVLAELGWCHYRALFAERPARTR
                     MSRQDFEDQYALLHTDPERLAKLAREAVPDPADRLDLDRLADPLAGLRFDRADDLQRQV
                     RGHLAEVLRGRTGPARGVATALVDGLQRAGAVIEELWRAGDLAADQVSEALGLFAIGTH
                     LSSGPPPLRAEQLLALAEAGVVTFVGPGMRVETAAAGRRTVYRATSPALPGVAHEAAVL
                     LDARLAAPAPERAADPLLRALLSRGELAAERTADGAASGMLRLSGAGLHPIGADGTEHR
                     DRIVAGPAQFPRPGTNAVYFRQNDAIARSLLGD"
     gene            complement(15192..15875)
                     /locus_tag="SL103_RS00720"
                     /old_locus_tag="SL103_00720"
     CDS             complement(15192..15875)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092317.1"
                     /locus_tag="SL103_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00720"
                     /product="response regulator transcription factor"
                     /protein_id="WP_069573233.1"
                     /transl_table=11
                     /translation="MRVLVADDQAAVRSGLVLVLQTDPGITVVGEAGDGEAAVRMAAEL
                     RPDVVLMDVQMPLLNGVAATRRIVERGLAEVLVLTTFDLNEYIFGALRAGAGGFILKNA
                     EPAVLVSAVREVAHGDGFLTPAIARRLITEFSGRLPAAGPPLPAGAGLPDDTTQALDSL
                     TKRELEVLACIARGLPNSAIAQTLSLAEGTVKTHISRILSKLHLRSRVQAAILAQQYGI
                     NAPQG"
     misc_feature    complement(15459..15461)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16029..17225)
                     /locus_tag="SL103_RS00725"
                     /old_locus_tag="SL103_00725"
     CDS             complement(16029..17225)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="SL103_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00725"
                     /product="histidine kinase"
                     /protein_id="WP_164492740.1"
                     /transl_table=11
                     /translation="MGFFAGCLILYVVGGPRVMGGDIAVWQAVLPVLVLCAATAYRSAL
                     PPLAVAVGTVTVLVEMTSSGGLGPVLIYTDLLYAAALYGATWLCRLLQFGTVAVTLATT
                     VALIVISDRSEGVTTGVIVALLLISPVWTGVLIRNHKERADTERERAAQINRLAELDRK
                     TVLQTERTRMARELHDLVANHLSAIAIHSSAVLSLSEAKREREGGRDDDGEEDPVLRAL
                     AVIRENSVQGLAEMRRMVVLLRSDRGVDDDWDRPQLNALGALVEQARPAADAAALTLYT
                     DFPESFPEVSSVIEVTAYRIVQEALTNVLKHASAGRVRIRCEAGAEQLTISVDSPLARS
                     DGRTRQRPVAQLTTGAGAGLAGMSERAALVGGIFDAGPDRTAPGRWRVRAVLPLTQNA"
     misc_feature    complement(17273..17286)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.3"
                     /tool="antismash"
     gene            17552..18352
                     /locus_tag="SL103_RS00730"
                     /old_locus_tag="SL103_00730"
     CDS             17552..18352
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SL103_RS00730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SL103_00730"
                     /product="4-phosphopantetheinyl transferase family protein"
                     /protein_id="WP_069566850.1"
                     /transl_table=11
                     /translation="METNAALLELCPEPLDQDVPDPRHHLVRTPPAPLAPAPSTDRPHP
                     HDHPDAAAVPVPIFVVPIESPTAPSAVSPAFDGSTSLLSPDNCLGLNGHSRATLDGASR
                     SWLLARLPARVATAMAAATHWELYGTRGLLVVACGEDARRMGFSVESVRREAAAPTTPY
                     EVLTAREARLAATCPDAERERLITRFWVRKDAAMQAVGRGLSIAPERIEAGFPTDHGTV
                     SVPGPYGLEVPVSVRNFAFAASYEFAVATAEPLPIAPSFAYSGT"
     misc_feature    17554..17565
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 21.4"
                     /tool="antismash"
     gene            18595..19146
                     /locus_tag="SL103_RS00735"
                     /old_locus_tag="SL103_00735"
     CDS             18595..19146
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092320.1"
                     /locus_tag="SL103_RS00735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00735"
                     /product="transglycosylase family protein"
                     /protein_id="WP_069566851.1"
                     /transl_table=11
                     /translation="MPSPHAKRSVVTILSVLLAVLSVLGLAAPAVATGAPLGSPVPDWE
                     RIAACESNGRWHINSGNGYHGGLQIDPATWRAYGGGQYAPRADLASRDEQISVARRIVR
                     DRGMSAWPNCSYTTGTRAVPQQAPPAAHSYVVRPGDCLSAIAERTGTPGGAKALYHLNK
                     HRLPDGADRIYPGQRLRLRA"
     gene            complement(19180..19974)
                     /locus_tag="SL103_RS00740"
                     /old_locus_tag="SL103_00740"
     CDS             complement(19180..19974)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891185.1"
                     /locus_tag="SL103_RS00740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00740"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_069573236.1"
                     /transl_table=11
                     /translation="MSGTSGTTEVRGGTSVGVATAARWVRRWEDQQQHYAVDRDERLTV
                     IADVVEHTTAGLAEPLVVDLGCGPGALAARLAARLPHAAIVAVDADPLLLGLGRAYYGP
                     AVRFVEAVIGRPGWLGALALDRPLDAAVSTTALHYLGEAALRRVYRDLADRLRPGGVLV
                     NGDHLRQDAGRLCEIARAVGRRRAERRRVRSHEDWDSWWAAAHADPALAGLLAERRTRP
                     LPASEGEHLTLSAHLTLLREAGFRHAGPVWQFGNSHVVVAVR"
     misc_feature    19999..20013
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.09"
                     /tool="antismash"
     misc_feature    complement(20001..20016)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.95"
                     /tool="antismash"
     misc_feature    complement(20004..20019)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.41"
                     /tool="antismash"
     misc_feature    complement(20006..20019)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.91"
                     /tool="antismash"
     misc_feature    20006..20020
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.23"
                     /tool="antismash"
     gene            complement(20012..21247)
                     /locus_tag="SL103_RS00745"
                     /old_locus_tag="SL103_00745"
     CDS             complement(20012..21247)
                     /NRPS_PKS="Domain: Aminotran_5 (42-403). E-value: 2.2e-74.
                     Score: 242.5. Matches aSDomain:
                     nrpspksdomains_SL103_RS00745_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005989.1"
                     /locus_tag="SL103_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00745"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_069566852.1"
                     /sec_met_domain="Aminotran_5 (E-value: 7.9e-71, bitscore:
                     237.6, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.7e-05,
                     bitscore: 21.0, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPVEDPPRRQTPDDDLVALRAWQRPLRAQFPIITAHPGLAYLD
                     SAATSQKPQAVLDAVLSYLTTSNANAGRGTYPWANATTALVEAARDRVKSFLRDPRPER
                     SAVHFTSGTTEGLRAVARDWLTTFLTDGDEIVVPFADHRANLAPWLEARDLLARRGIGV
                     RVRALPCQEGSGDYDPAALAAQLTPRTRFIAATHVHHVYGADMNVHRLREVAGPAVPIC
                     LDAAQSVGHLPVSTDRLDVDFVVFSGHKALALPGTGAVWARGLRGPRFRPGGWQGTPNT
                     AGIAGLAAALDWLDAAGTDRIERWTVALAARLTDGLGRLDAYEVLGCRESLSAASRVQR
                     RRSIVTFRHRAISSTDLGFILYSHGFMVRSDHHCQAGAPAGGEDGSVRVSLHVHNTPEE
                     IDALVSTLTSLQ"
     aSDomain        complement(20039..21121)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SL103_RS00745_Aminotran_5.1"
                     /evalue="2.20E-74"
                     /label="SL103_RS00745_Aminotran_5.1"
                     /locus_tag="SL103_RS00745"
                     /protein_end="403"
                     /protein_start="42"
                     /score="242.5"
                     /tool="antismash"
                     /translation="YLDSAATSQKPQAVLDAVLSYLTTSNANAGRGTYPWANATTALVE
                     AARDRVKSFLRDPRPERSAVHFTSGTTEGLRAVARDWLTTFLTDGDEIVVPFADHRANL
                     APWLEARDLLARRGIGVRVRALPCQEGSGDYDPAALAAQLTPRTRFIAATHVHHVYGAD
                     MNVHRLREVAGPAVPICLDAAQSVGHLPVSTDRLDVDFVVFSGHKALALPGTGAVWARG
                     LRGPRFRPGGWQGTPNTAGIAGLAAALDWLDAAGTDRIERWTVALAARLTDGLGRLDAY
                     EVLGCRESLSAASRVQRRRSIVTFRHRAISSTDLGFILYSHGFMVRSDHHCQAGAPAGG
                     EDGSVRVSLHVHNTPEEIDAL"
     gene            complement(21249..22589)
                     /locus_tag="SL103_RS00750"
                     /old_locus_tag="SL103_00750"
     CDS             complement(21249..22589)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056545.1"
                     /locus_tag="SL103_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SL103_00750"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_069566853.1"
                     /sec_met_domain="PALP (E-value: 8.9e-46, bitscore: 155.3,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYDSITDAIGDTPLVRIDPAVHGLRHIDLYAKLEMLNPFGSVKD
                     RAAWNMARPGLPDAVRRGATIVELSSGNTAKALAVIAGMHGLPFKSVTNRMRVPEIKEL
                     LLLLGAEIEELPGRSECLDPTDTEDPLTLFHQELTRPGRPSLHTDQYFNDLNTAAHAAG
                     TGPEIIADLDGRAPDWFVACVGTAGSSTGVARALRAHDPAVRVVGLVGEKSDFIPGIRT
                     LDEVHEVGLFDPATYDTIEAVAADDALDGMLTLIRRCGLLAGPTGGAAYHGAVRHLRPL
                     DAESAGAAGADGRRRTAVFIVCDRVESYLGYVRERRPELLGRPPARNSVATLTDAEIRA
                     TTVIDTTDARKWIAAERPLVVDLRGPFAYAALHIDGSINIVDELFDELLRGGLPFSKRQ
                     PVLLACPVGEKSVRYAALLTRMGHPDVRSLAGGIIAWRDAGAPLVRD"
ORIGIN
        1 actcgccgct gtcgacggac gcggacaaca gcgccacccg ggcctgggcc cgctccggac
       61 gcccgggctc cagctcgccg gtgacccgta ccgcctcctc ggcgaagcgc acgccctccg
      121 ggagacggcc cgcggcgcgc agcagctggg ccagctcgat ggcgacccgg gcgtgcagca
      181 ccggggcgga gcgggtgagc gggtcgtcga ggaggtggcg cagcgccgct tcgtggcggt
      241 ccggttcgtc gagccggccg aggacggtgg ccagctccca gcgggcctcc cagcgcacct
      301 cgtcctggcc ggcgccgccg gtctgctcca ccagggactc cagctgccgg cgcgccgcgg
      361 gccagtcgcc ggccagcgca ctggcgcggg ccgccaccaa ctggccgacc aggcccaggc
      421 ggtgggtcag ccggtcgccc ggctcctcgg cggcgctgag cgcctcgacc gtcgtgccga
      481 gccgttcggc gagcgaccgg gcgatcttcg cgcccggaat tctgcggccg ttctccacca
      541 gcgagacgta gctgggggag aggtcgtccc cggcgaggtc cccttgggac agaccctgag
      601 tgcgccgggc ctcccgcacg cgcttcccga aagcaggctg ctcaatcacc aagaaaatcg
      661 ctcgcagttg agtggggtgg acggacggtg acgatgtacg gacggctccg gacggaggcc
      721 gtgtgatgac ggggagtcta ctcaccggcg gtccgcccgg gcatgcctgt ggacgacgtt
      781 ccctcgtccg gggagtcatt ttttgtcact tacggacgtc gggattccct ttgctgtcgg
      841 gcgcgcgtta cgacagttga gaggcgcgtc cagccctacg gcgcacgggg cggcggggtg
      901 tcgtcgggcg acctggagcc atcgcggggg cggctgcttg tcatatgagc cagtcgagtg
      961 caatgacttt acttgacaat aaatgacaat tggctgacgc tgaccctcca tggactacgc
     1021 ccccaggagg gacatatgag ctccgctccc gcatggccga ccgtggccgc cgagccggag
     1081 ggcagcctcg cgcgccatcg tgcggcggcc gtgcaccggg tccgggactt cctggtgaac
     1141 gacgccggta ccgtgcacga gctgctgtgc gagatctcca cccaccgcgc cgcgcgctac
     1201 gagatcgagt cgaccgtcgc caccctcgac ggggccctgg acgaggtgac cgcccaccgg
     1261 cccggccggg tcccccggct ggccgccttc atgccgtcga acgtcatcct ctactcctac
     1321 gccctgtacc tcctggtgcc cgccctctac accgaccgcc tggtcttccg cccctccagc
     1381 cgcgtcaagg accagatgcg ccggctgcac accctgctcg ccgcgcagca cggcctgccc
     1441 atcgagctca ccaccgccag ccagcgggac ttcctgcacg accacgtgct ccccgccgac
     1501 gtcgtggtct tcaccggcgc ctacgccaac gccgagcaga tccgcgcccg gctctccccc
     1561 ggtcagctgt tcctcttcct cggctccggc gtcaacccgt tcgtcgtcgc gcccggtgcc
     1621 gacgtcgagc gggcggctcg cgacgccatc gccatccggg tcctcaacac cggccaggac
     1681 tgcctgggcc ccgacctctt cagcgtccac gagacgctgc tcgaaccgtt cgtcgacgcg
     1741 ctggtcagcg agttgaaggg gctgcgctac ggcccgtaca ccgacccgga cgccgacttc
     1801 gggccgatct tctacgacag cgcgctggag gacggcgcgc agttcctcgc ccgccaccgc
     1861 ggcgccatcg tgcacggcgg acacgtcgac ttccgcggcc gccggctcga ccccaccgtc
     1921 gtcgtcggcg aggaggtcac cccgcgcacc cacgtcccgg agttcttcgc gccgatcttc
     1981 aacgtcgcct cctaccgcga cgaggacgcc ctcgcgacca cgctcaccac cggcatgttc
     2041 accgaacgcg ccctgggctc cagcgtctac ggccacgccc cgcgcctggt cgaggcgctg
     2101 cgcaggcgta ccaccgtcac cctggacacc actctgctgt ccatcgacga cggcaacgcc
     2161 ccgttcggcg gctacggccg gatggccaac tacatctccg acggacacga gctgcgcgcc
     2221 gagcccgtcc tgctctccaa ggccgtcgcc gcccaccgcc cgggagccgc ccgatgaccg
     2281 cgacgaccca ccccaccgcc tgggccgcgc tcgcggacta cctgcgccac ctcggcaccg
     2341 gggcggtctt cgggctgccc ggcgacgaca tggcgctgct cggcgagctg gagcgcgccg
     2401 acaccccggt cgtgctctgc cgcgaccagc gcaacgcgct gttcatggcg acggggtacg
     2461 cgctcgccgc cggccgcccc ggcgtctgcg tgatcggcaa gggcccggcg ctgaccaacg
     2521 cgctcaccgg cgtcctggag gcgcggtcgg ccgccgcccc gctgatcctg atcgccgacg
     2581 gcacccgcct cgaccggctg ggcaccggcg ccttccagga gctggaccag ctgaccgcgg
     2641 tccgcccgta cgtgaagtgg gcggcccgca tcgaccacgc cgaccggctg cccgccgccc
     2701 tggagaaggc cgccgcgctc gccgtcaacg gcacgcccgg ccccgtctac ctggagctcg
     2761 ccgaacagct cgcggaccag ccggtcaccc gcagcggatc ctggcgcccg gtcgcgccgc
     2821 agcggccgtc ccccgaccag gacgcgctcg ccgcgaccgc cgagcgcatc gccgccgccg
     2881 agcggccgtt gctgctggtc ggcggcgggg cccggcaccg caacaccggc cggcgcatcg
     2941 agcggctcgc cgagcgcctc ggcgccggcg tgttcaccac cgcctccggc cgcggcgcgg
     3001 tcgccgagga ccaccccctg tactgcggcg tcagcggcct ctacaccgtc gcgccgatgg
     3061 acgcgctgtg gcgcgaggcc gacctcgtca tcgccctggg cagccgcctg gaggagaccg
     3121 ccaccttcgg ctggcccgag gacgccgcgc aactccccgt ggtccaggcc gtgctgggcg
     3181 aggagagcct ggtcatggag cggcccgggg cacacgtcct cggtgacgcc gggcggatcg
     3241 tggacggctg ggcggagctg ctggccgggc accgggcgac cggcgactgg cccgagcgga
     3301 tccgcaccgc gcggaccgcg ctggcgcagc gcgccgcgga ccgtgccgag gaggccgtca
     3361 agcgggtgcc cgagggggcc gtcccggtct cgcaggtgct ggccgccctc gaccgcgccg
     3421 tccccgccgg ccgggtcctg gtccaggaga acggccttca ggacatgtgg tcgtacttct
     3481 tcccgcacta cgcgctgggt accggcggcg ggtccgtcgt gcccagtgag cagaccccgc
     3541 tgggcttcgg cgcggcggcc gcggtcggcg tacggctggc cgagccggcc gggcggccgg
     3601 tggtcgcggt ggtgggcgac ggcgccttca acctcttccg ctgcgagctc cccaccgtcg
     3661 cggacgccgg cgccgcggtg ctctacctcg tgctggacaa cggcggttac ggctggctcc
     3721 agtccaacct cgaccgggtc agcggccccg cctcccgctt ctccttcacc accccgcgcc
     3781 ccaccggcac cgagggcgtg tccctcgccc acggtctggg atacgcccgg gtcacgaacg
     3841 ccgaggacct gcccgccgcg ctgtccgccg cctggcaacg ggtcgcctcc ggcaccacct
     3901 cgatcgtcga gatagccgtc gccctcccgg acacaccacc gggaatgacg gctgcgtcgg
     3961 gtgacttccc cgagcgggag tgagtgcttc ccacgttgtc ggctttcccg ccgtgtttgt
     4021 tgctcgccgg tgcgctttgc ggcgccgcgt acgttgtcgg ctttcccgcc gtgtttgtcg
     4081 cccgccgttt cgcctgcggc gggcgtgggt ggtcgggtgc ggtgccgctc ctccggactt
     4141 cgtcctgcgg cgcggcccct cccgtagggg atgagaaaag gccggtgggg gcgggcgtcg
     4201 tgactgacgc ccgccccacc ggctttttcc cggggggcgg gggggctagc tcttggcccg
     4261 gaacttggcg atcgccaagg gggcggtgac cgcggtgagg gccagggacc aggccagggt
     4321 ccacaggacg gggccggcca ccgggccctc gcccagggcg agtccgcggg ccgcgtccgc
     4381 catgtgcgtc agggggttga cgcgggtgaa ggcccgcagc cagtccggca tggtcgtggg
     4441 ggacacgaag atcgaggagc cgaactgcag cggggtcagc accagaaccg agaggccctg
     4501 gatcgcctgg gcggagcgca gggtcaggcc cagcagcatg aagatccaga tgagcgaggt
     4561 gccgaagacg gtggtgaggc cgaccgccgc ggcgatgccc ggccagcgcc cggtgaagtc
     4621 gaagccgagc acggccgcga caagcagcag gaccgcgatg gcgaccagca tccggccggt
     4681 ctccaccacg accttggcca gcagcaccga ggagcgggcg atgggcatcg tacggaaccg
     4741 gtccatcacg cccgtacgga agtcgtcgtt gacgccggtg cccacggcca tggcgatggt
     4801 catcccgagg atcaccatca ggccgggcac caggaaggcg gtgtaccggg cccgggagcc
     4861 gccgaccgcg ccgccgaaga cgaagacgaa gagcaccgtc agcacgatcg gcatcaggag
     4921 cgcgtcggtc atcgactcgg ggttctgccg gatctgcagg aggttgcggc ggaccagggc
     4981 cccggtgtgc cgggccatgg cccgcgggcg tatccgtccc tcgtcgccga gcgggacgtc
     5041 ggcagcggta cggggcaccg cctgatgcac cgtcacgccc ggccgcgccg ctcgtcgagc
     5101 caccgctgcc agtacgtgcg ccggtcgctg ctcgggtggg cgacgatgat gtcgccgaag
     5161 acggcggagc cggtgatgcg cacgcgcggg gtgactgctt ccgggccgga gtgctcccgg
     5221 atcaggttgc gcacgtcgcc gaggacggtg ctgcagttca tctcgacccg gacgccttcc
     5281 gggagcagca ggtggatgtc gccgatgatc gcgcgggcct ggatggtcag ctcgccggtc
     5341 gacggggcgg gggacgcaca caggtcgagg gtcaggtcgc cgaagatcgc ggtggcctcg
     5401 atgccgtgtt ccagggaggg gctgtgatgg gtgacgtcgc cgaaggcggc gcggaagctg
     5461 cgctggccgg tggcggttct ggcggactcg ggggcggtga cgtgcggcag gtcctcgccg
     5521 accgagctca actcctcgcg ggtgcgggcg agatacgcgg cctcggaacg ctccgccagt
     5581 tcctccaggg tcagccggcc ctcggcggtg gcctccctga gccgctcgac catgtcctcg
     5641 cgttcggcgt ccgacgccag gaccgagcgc gaggagacgg acgggggcgc cagatccttg
     5701 tgcagatcgg ggcgttgggg ctgcgtcatg gagagtgcct ccgcggggtc cggcaggggt
     5761 gggacgtcgg tcgcctcatc ggaccacgtc acaccgggcg cggacatcgc cgtggggtag
     5821 tacatcgaaa ggttgaccct cggcggcggg gcacacagtt cggtgtactc ggcggccggt
     5881 tttttcggcg cccgggcgtc cggcgaaatg atctcggaga gctggtgaag accggtgaag
     5941 gaatccgaat atcggtcgac ttcttcttga ctagttggta aagtgcgcag cactcattgt
     6001 gactcgccga tttgatgcag ccggccggag tcatccaacg ttcgaaatcc ggagggcttg
     6061 tcgaatgcct gagctggcgg acaccgggcg gcgaatcaaa gagcttcggg tcagcgcggg
     6121 aatgacacag cacgaccttg ccgggtccga aatgtcgtcc agctacatct cgctcgtcga
     6181 acgcgggaag cgcattccca gcggccgggc gctgcggatc ctggcggaac gcctcggggt
     6241 cggcgtggac gaaatatcca gaggagccga gccggtcgaa acccctggcc gggtacggcg
     6301 gctggacctg gtcggacgat tggtggcggc ccgccggcaa tgggagggcg gcgacgccga
     6361 gggcgcgctg tcggaattcc gcgcactggc cgagaccgac cccgccggac ggcaggacga
     6421 cgtatttacc gaggcccagc tcgccattgc cgaaatactg ggcacgctgg gccgcgccga
     6481 cgagggcgcc gaggtcctgc tgcggatgct ggacgcgctg gcccccgccc cgtacgcgga
     6541 ggcccggctg cgcgccctga tcgcgctcgc cgacctgctg gagtcggccg gccgggtgca
     6601 ggacgggctg cgctacgcgc tcaccggctt cctcgaatgc gccgaccgga gcccgggcag
     6661 cggcttccac gccctgctcg tgctggaggt gctcacccgg tgcgcgtact ggagcggctg
     6721 ccccgactgg gcgcccggca ccgaccacgg ccggccgtcc gcggacggcg tgctccccgg
     6781 gccgcgggcc accatcgatc tgcaccgggc gctcgatctg cgcgaccggg gcgaggtggc
     6841 gcgcgccgcc gagctgctgg gggagtgcgc gcgccgggtc accccggccg ccggcttccc
     6901 gctctgggag aagatcagcg gccactacgc cctgctgctc ctggagcgcg gcgaggcggc
     6961 ggcggcccgc agcatcgtcg agcgcggcct cgtcgtcgcc tcggtggcgc aggagccgga
     7021 cttcccgctg tggctgagca ccgcgcaggc ggtgtgcgcc caggcggccg gcgacgcgga
     7081 ccggctcttc gcgctgggcg aggaggtggc cgcgctgccc gacaccggcc gcagccacga
     7141 gaaagccgcc gcgctcggtg agatcgcggc ggcttgtgag cgggcggggg accgggaaag
     7201 ggcggccgga cacttccggt attccgcgga gctgttccgg cgggcccagg cgtaccggca
     7261 cgccgagcgg gcccgggaac ggctggcgga cctcctcgaa aagcgcggct gacgccggcg
     7321 gggtaaagcg ccgcggcgcc gcaaatgccg ctattgcgcc caatgcgcgc ttatttatta
     7381 gccttctttc caaggcccag gagtgcgaac agcgcctccg caccaccgac gatcgcgagc
     7441 accagaccgg ccttgtggag cgagaccacc ggagtctcca cttcctttgt ggtcagccac
     7501 aggatcagtc cgacgatcgc cagaacaata cctaccgcaa tacccttcat cggttccctc
     7561 gtccctagtg acggtgcccc gcacgatgcc gcgggggcag ttgtacggac cagcgtcccg
     7621 tcggaccggg ccattcggat catccgcagg taggcacttt ccgccccggc gtctgtcact
     7681 ttctatgtac tccggcccct acccggaggc tgtccggggc cggagcgggg ccgtccgggg
     7741 gcggtggacg cccctccagc gccgccagcc tggcccgtac agtcaatttt cgtgacagtg
     7801 cgagtcatgc gtctgagagc gttttcgctg gtacggggcc tggtgggcca cgttgtcatc
     7861 gcgcgaccgc cctctgactc tccggccgac tgttgacagg tcgatgactc agctgtcatc
     7921 tttctggtca tgaggacgcc ccaagcgtga caacggggca ggaattcagg aggtgggttt
     7981 catggagttg cgcacggatc ggcggcgtgt cgtcgtcacc ggctgcggcg tggtctcccc
     8041 cgtgggaaac accaccgcgg acttctggaa cgcccttctc gacggccgca gcggaatccg
     8101 cgccgtcacc cgcttcgaca cctacgggct cccggtccgt atcggcgggg acctcaccgg
     8161 attcgacacc accggctgcc tcaccccgca ggaggcccgg cgcagcgaca acttcacgca
     8221 gtacgcggtg gtcgccgcgg tccaggcgat gcgggccgcc ggcctcgcaa caccggccgg
     8281 catcgacccg caccgcttcg ccgtggtgat cggctccggc tacggcgccg ccatcgccat
     8341 ccagcagcag tacgacgtgc tgcgggagca cggaccgcgg cgggtctccc cgtaccactc
     8401 ggtgctcacc gccatcgacc acccggccgg cctgctgtcc atcaagtacg ggatcagcgg
     8461 accgagttgc gcggtctcgg cggcgtgcgc caccggcgcg gtggccatcg gcgaggcggt
     8521 cgagatgatc cgccacggcc gcgcggacct cgcgctggcc ggcggcaccg acgactccct
     8581 caccgcggtc gacctggccg gcaccgccaa cgcacaggcc ctctcccgcc gcaacgacga
     8641 ccccgaaggc gccagccggc ccttcgaccg ggaccgcgac ggcttcgtga tgtccgtcgg
     8701 ggccaccgtc ctgacactgg aggaggccgg tcacgccgag cggcgcggcg cggagatcct
     8761 cgccgaggtc gccggctacg ccgccaccac cgacgcccac cacgccaccg cccccgatcc
     8821 gaccggcgcc ggagccatcc gcgcgatgcg cggcgccctc gccgacgcgg ggtgcgtgcc
     8881 ggaggacgtc ggccaggtca gcgcgcacgg caccggcacg gtcctcaacg accgcatcga
     8941 ggccgcggcg ctgcgcgagg tgctcggccc cgaccagctg cgccggacgc cgatcaccgc
     9001 ggtcaagagc atgaccgggc acatgctcgg tgcctccgga gccgccgagg ccgccgccgc
     9061 ggtgctctcc ctccgggacc acgtgatccc accggtccgc aactgcgacc accccgagga
     9121 ggaagacctc gacctggtcg tcaagggcgc ccgcgagtgg gacggcgacg tggtgctgag
     9181 caattccttc ggcttcggcg gccacaacgc cgtcctcgta ctcaagcgct ggacccgctg
     9241 accccaccca cagagaagga ggtaaacgca ccgtgcaggg acgactggtg accttggaat
     9301 ggcccggcga cgacgactgg gccgcgatcg cctcctggct gcggcccggc tcgccggccg
     9361 ccgtactcag cggggactgg gaactgctgg gcgccgccga ggtcgagcag gccaaccgct
     9421 cgggccgggt ccacaacctg gtgatccgcg ccaaggacgg cgagcgcatc gggaccgtga
     9481 gctaccagcg ctccggccgg atcggcggct acaccgtcgg cggcgcgatc ggctcgcccg
     9541 agctgtggcg ccgcggctac ggcgcggagg ccgtcgtgct gctcgtcgac tacctcttcc
     9601 accagctcga cgcccacaag gtgcaggtca ccaccgccgg ttacaacaag ggcatcatcc
     9661 ggctgatgac caagacccag ttcgtggtcg agggcatcct gcgggaccac tgctacctcg
     9721 acggcgagta ccacgacgcg atcgtgtggg gcctgctgcg cgacgagcac tacgcctcgc
     9781 tcaagcccag cgacgacaac cgcgtactgg ccgtcgggct cgcggacttc gtccccgagg
     9841 acgacaagac gcaggcccgc gccgtgctcg cggagcacct ggcgagcacc gggcgcaccg
     9901 cgctggcgcc ctacctcgac ggggcggcgc cccgaccggc cgcggtgccc gcggacccgt
     9961 ccgacgccgc cggccgcgcc gagcccgcgc gaggtgccgc atgagagacg gcgccgagag
    10021 cttcgccctg gccgaccgca ccttcttcga ctggccgggc aactgggacc tggaagccac
    10081 ccgcttcccc gccccgcccc tgcccgacgg ctggacccac gacgagaacg aagcctgggc
    10141 cttctgccgc ccgcccgagg accgcctccc cgaccagggc tggaagatcc acgtcagcgc
    10201 ggcccccgac gacgccgccc gcaccatcgc cgacgtcgcc gcctactgca cccggcacgg
    10261 cctgacgttc aagtacctca agagcgccaa cgtcctgcgc gccctgagcc gcaagtacgc
    10321 ccagcgctcc tcggccggca agctgctgac cgtctacccc gtcgacgagg ccgacctggc
    10381 ccgcaccctc gaagggctcg acgcgctggt cggcggccgc cccggcccgt acgtcctgac
    10441 cgacctgcgc ttccgcgagg gcccgctcta cgtccgctac ggcggcttcc gcacccacta
    10501 cacggaagac gccgacggcg aactggtcac ggccttccac cgccccgacg gcaccccgga
    10561 gccggaccgc cgcacccccg tcttccacac ccccgactgg gtcacggtcc ccgacgtgct
    10621 gaaggaatcg ctggccgccc ggcaggcgct ggacgacttc ccctaccgga tcaccggggc
    10681 gctgcagttc tccaacggcg gcggcgtcta ccgcgccgcg ccgctcggca cggacgccct
    10741 cggtgcgggc gagaccggtg tcgtcctcaa ggagggacgg ccgtggtccg ggacggacgg
    10801 cgtcggccgc gacgcggtca cccggctcgc ccacgagcac cggatgctcc agcggctggc
    10861 cggcctcccc gggataccgc ggaccttcgg caccctccag gtgcgcgacc acctcttcct
    10921 ggtgctggag gacatcgagg gccaggactt ccagacctgg ctcgccgccc accacccgct
    10981 gaccgtgccg gaccccgacg agcaggccgt cgcggactac agggaccgcg cactcgccct
    11041 gttcggccgc atcgaggcgc tggtcgccgc ggtgcacggg cgcggcgtcc ggatcggtga
    11101 cctgcacccg ggcaacctca tcatcaagcc gggcgacgaa cccgtcctcc tcgacttcga
    11161 ggtcgccgac gagatcgacc gggccacccc cagcagcctg ggcgcccccg gcttccaccg
    11221 cgccgacgcg accggcgcgg acggggaccg ctacgccctc gccgcgatcg gcctgtggct
    11281 cttcctgccg ctggccgccc tcggcgggct cgcccccgac aaggcccccg ccctgctggc
    11341 caccgccgcc gagcgctacg ccctgccgga cgcgctggtg gcgcggctgg cgccgcagct
    11401 ggcccccaac gacgacacga cgtccgaact ccgctccctg ccagggacgt tcccacccag
    11461 cgacgtcctg gcctccctgg gccgcgggct gcgcgagagc gccaccccgc accgcgccga
    11521 ccggctccac cccggcgact tcgagcagtt cgtcgagggg ggcgcgggct tcggccacgg
    11581 cgccgccggt gtcctgtggg cccggcacac cgtcctcggg gagcgcgacg aggagggcgc
    11641 ggcctggctg cgcgccgccg tcgaccgggt ccccgccgag cggatcggct tctacgacgg
    11701 cctgcacggc atggcctacg tcttacagga gctcggcgac gacgaggcgg cccaacgggc
    11761 cctcgaccgc gccgcggacc ggctccccgt gcgccactgc cccagcctct accgcggcct
    11821 ctccggcgtc ggcctgaacc tgctgcactt cgccgacgcc ctggaccgcc ccgacctgcg
    11881 caagcaggcc ctcgacctgg ccggccgggt caccgaacga ctggccgcgg cccgcaccga
    11941 acccgtcgag cgcaggcgcc gacgcggtgc gcaggacgcc gccgggctga tgtacggctg
    12001 gtcgggcgcc gcgctcttcc tgctgcgcgc ccaccaggcc accggcgacc ccgggttgct
    12061 ggaccaggcg gtgctcgccg tccaccgcga cctcgaccgg tgttcccccg gcccgcagga
    12121 caccctccag gtggacgagg gcttccggct cctgccctac ctggacaacg gcagcgccgg
    12181 gatcgccctg gtggccgccg cgctgctgga ccaccgggac gacgaccgga tccaccaggc
    12241 cctgcccgcc ctgctgcgcg cctgcgccgc cgacttcgtc atcgagtccg gcctgctggg
    12301 cggacgcgcg ggactgctcg ccaccctggc ggccctccgc gaacgggcgg cgctcccacc
    12361 ggaacggacc gaccgctacc tgcgccggca cctgaccaac ctcggccagc acgccatgac
    12421 gcggaacggg gcggtggtct tcccctgcga cggccgcgcc cggatctcca tggacctggc
    12481 cggcggcggc gccggagtcc tgctggcgct ctccaccacc gaacggggca ccccgctgct
    12541 gccgttcctc acagactcgc gccccgcggc ggccgttcat ccggccgcac cgggacgcgt
    12601 cggcggcgcc cacggtgccg tcacccccac cgccccgtcc ggggcagcgg gcactgcgca
    12661 ccacggaagg gaggtgtcgt aaatgaccat catggatctt cagggtctgg aggtgccggg
    12721 cgagcgtgac gcccaggctc tcggctccac cgtctccggc ggctgctgac gcgacgccgg
    12781 acgggccgcg caccgaaatg cacggcccgc cggctccagg tgtcccgcaa cggcacctgg
    12841 tacgtcacca ccgttgatca tccgcgactc accctcggaa ggaggtgtcg acaaatgacc
    12901 atcatggatc ttcagggtct ggaggtgccg ggcgagcgtg acgcccaggc gctcggctcc
    12961 accatcagcg gcggctgctg aaccggctga ccctttgacc acacggtgct tgatcacacg
    13021 aggtttgctc acacgtttga tcacacggtg ctcggtttcc accacgcacc gtgcatacca
    13081 ccgtacacac gttcaccgat tctcggaagg gaggtgtcga caatgaccat catggacctt
    13141 cagggcctgg aggtgccggg cgagcgtgac gcccaggcgc tcggctccac catcagcggc
    13201 ggttgctgac acggcgcccg gtggtcccgc actacggtgc gggccaccgg gcccctgtgt
    13261 tttctgacgt cagtccccgg ccgtcgggca cctctcgcac ggccaccggc caacggacgg
    13321 aggccagttg aaccggcaag tgggcccggc ccgctccctg tgcgtcatcg gctgcggccc
    13381 gcgcggcacc tcgatcgtcg agcggatcct cgccaacgtc cccgccctgt acggcgaccg
    13441 gccgctggac ctgcacgtcg tcgacccgta cccgcccggc gccggccgca cctggcgcac
    13501 cgaccagccc ggcctgctgt ggatgaactc cgccgccgag caggtcaccc tgtaccccga
    13561 cgcgagcgtg gactgcgcgg gcccgccgcg ccccggaccc accaccgccg gatggctcga
    13621 cgccccgctg cacgacgggg cctacgccgc ccgccgcgac cagggccgct acctgcgcca
    13681 cttcttcgac accgtcaccc gcgaactccc cgccacggtg cggctgtacg tccaccgggc
    13741 gcgcgccgtc gacctgcgcc gggtgaccgc ggacggcctg ccgccggcgc cgggggacac
    13801 cccggcaggc cgccagcagg tggtcctcga ctccggcgag gcacccttcc tggccgaccg
    13861 ggtcgtcctc gcccagggcc acctggagac ccgcaccgac cccgcgccgc ccggcctgac
    13921 ccggatcggc ccgggccccg ccgacccgga cgcgctggcc gccgtgccgc ccggcgaacc
    13981 cgtcctggtc cgcggactgg ggctggtctt catcgactgc ctggcgctgc tgaccgaggg
    14041 ccgcggcggc cgcttcgtcc gcaccgcccc cggcgggccg ctgcgctacc tgccctccgg
    14101 acgcgagccg cggctgtacg cgggctcccg ccgcggggtc ccgctgccgc ccaaaccggc
    14161 gcgcggcgcc ccggacgccc cggccgcggc ccccgccgcc ccgcgcttcg ccaccctcga
    14221 cgcctgccgc gcccggctgg cccgtcccgc cgccgccttc ggccgcgacg tctggccgct
    14281 ggtgctcgcc gaactgggct ggtgccacta ccgcgcgctc ttcgccgagc ggcccgcccg
    14341 tacccggatg agccggcagg acttcgagga ccagtacgcg ctgctgcaca ccgaccccga
    14401 gcggctggcc aagctcgccc gcgaggcggt gcccgacccc gccgaccggc tcgacctgga
    14461 ccggctggcg gacccgctcg ccgggctgcg gttcgaccgg gccgacgacc tccagcggca
    14521 ggtgcgcggc catctcgccg aggtcctgcg cggtcgtacg gggcccgcgc gcggggtcgc
    14581 gaccgccctg gtcgacggcc tgcaacgggc cggtgcggtc atcgaggagc tgtggcgagc
    14641 cggcgacctg gcggccgatc aggtcagcga ggcgctgggc ctcttcgcga tcggcaccca
    14701 cctcagctcg ggcccgccgc cgctgcgcgc cgagcagctg ctcgcgctgg ccgaggcggg
    14761 cgtggtgacg ttcgtgggac ccgggatgcg ggtggagacc gcggcggccg gccggcgcac
    14821 ggtgtaccgg gcgaccagcc cggcgctgcc cggcgtcgcc cacgaggcgg ccgtcctgct
    14881 cgacgcccgg ctggcggcgc ccgcacccga gcgggccgcc gatcccctgc tgcgcgccct
    14941 gctgtcccgc ggcgaactgg cggccgagcg caccgcggac ggcgccgcga gcgggatgct
    15001 gcggctgtcc ggcgcgggac tgcacccgat cggtgcggac ggcaccgagc accgcgaccg
    15061 gatcgtcgcc gggccggcgc agttcccccg cccgggaacc aacgccgtct acttccggca
    15121 gaacgacgcg atcgcccgca gcctgctcgg cgactgagcg cccgcccggc accgggcccg
    15181 ggccgggcgg ctcacccctg cggcgcgttg atcccgtact gctgcgccag gatcgccgcc
    15241 tgcacccggc tgcgcagatg cagcttcgac aggatccggc tgatgtgggt cttcacggtg
    15301 ccctcggcga ggctgagggt ctgtgcgatg gcgctgttgg gcagcccgcg ggcgatgcac
    15361 gcgagcacct ccagctcccg cttggtgagg gagtccaggg cctgcgtggt gtcgtccggc
    15421 agcccggcac cggccggcag cggcggtccg gccgccggta agcggccgct gaactcggtg
    15481 atcagccgcc gggcgatggc cggggtgagg aacccgtcgc cgtgcgccac ctcccgtacg
    15541 gcgctgacca gcaccgccgg ctcggcgttc ttcaggatga agccgccggc cccggcccgc
    15601 agcgccccga agatgtactc gttgaggtcg aaggtggtca gcaccagcac ctcggccagg
    15661 ccgcgctcga cgatcctgcg ggtggcggcg acgccattga gcagcggcat ctgcacgtcc
    15721 atcagcacca cgtcgggccg cagctcggcg gccatccgga ccgccgcctc cccgtcaccg
    15781 gcctcgccga cgacggtgat gcccgggtcg gtctgcagta ccaggaccag cccggaccgc
    15841 acggcggcct ggtcgtcggc caccagcacc cgtatgccgg gcggccgccg gtccgccccc
    15901 tcccccggcg cgtccgccgt cgcgtcctgc acgctgtcct ccaccggctg cctcactggc
    15961 tgttccacct ctcgtcctca ccgcccccgt gccggacccg gggccgtgtc gccccgggag
    16021 tcgtccccct atgcgttctg ggtcagcggg agcaccgccc gtacccgcca gcgcccgggg
    16081 gcggtgcggt cgggtcccgc gtcgaagatg ccgccgacca gcgcggcccg ctcggacatc
    16141 ccggcgagcc cggcgccggc accggtggtc agctgcgcca ccggccgctg ccgggtccgg
    16201 ccgtcggagc gggccagcgg gctgtcgacc gaaatggtca gctgctcggc gccggcctcg
    16261 cagcggatcc gcacccggcc cgcggaggcg tgcttgagga cgttggtcag cgcctcctgc
    16321 acgatgcggt acgcggtcac ctcgatcacc gacgacacct cggggaagct ctcggggaag
    16381 tcggtgtaca gggtcagcgc ggcggcgtcg gcggccggcc gggcctgctc gaccagcgcg
    16441 cccagcgcgt tgagctgcgg ccggtcccag tcgtcgtcca cgccccggtc ggaccgcagc
    16501 agcaccacca tccgccgcat ttcggccagt ccctgcacgc tgttctcgcg gatcaccgcc
    16561 agcgcccgca gcaccgggtc ctcctcgccg tcgtcgtccc ggccgccctc ccgctcccgc
    16621 ttggcctcgc tcagcgacag cacggcgctg gagtggatgg cgatcgcgct gaggtggttg
    16681 gccaccaggt cgtgcaactc ccgtgccatc cgggtgcgtt cggtctgcag cacggtcttg
    16741 cggtccagtt ccgccagccg gttgatctgc gcggcgcgct cccgctcggt gtccgcccgc
    16801 tccttgtggt tccgtatcaa caccccggtc cacaccgggg agatgagcag cagggcgacg
    16861 atgacgccgg tcgtcacccc ctccgagcgg tcgctgatca cgatcagggc gacggtggtg
    16921 gcgagcgtga cggcgacggt cccgaactgc agcagccggc acagccaggt ggccccgtac
    16981 agggcggccg cgtacagcag gtcggtgtag atcagcacgg ggcccagacc gccgctcgac
    17041 gtcatctcca cgagcacggt cacggtgccg acggcgaccg ccagcggggg cagggcgctg
    17101 cggtaggcgg tcgcggcaca cagcacgagc accggcagga ccgcctgcca gacggcgatg
    17161 tcgcccccca tcacccgggg gccgcccacc acgtacagaa tcagacagcc ggcgaagaat
    17221 cccacggcca atctgaggtc gcggagcggt atggggcggc ggcgcgcgtg cgttcttgtg
    17281 aaaagacgta accacacacg aggacagtac tggggcgtgt cgcccgttct cttggccctg
    17341 gcgcccgaat ttgggtcggt ctcccgtaca tcgaagtatg tagccgtaca tcagcaggag
    17401 ggatgactcg aaggctccgg aggatctgca aaccttgggc tgtctgtatc gatcgatgta
    17461 ggcgaaaaag ggggagacag cttctgtatg acggcctgtc actcacccag tgcggcctcg
    17521 gcaccgctca actgtggagg acggaaagta cgtggaaacg aacgccgctc ttctcgaact
    17581 ctgtccggaa ccccttgacc aggacgttcc ggatcctcgg caccacctcg tccggacccc
    17641 tccggcaccc ctcgcacccg caccctcgac cgaccgtccg cacccgcacg accacccgga
    17701 cgcggcggcc gtccccgtac cgatcttcgt cgtccccatc gaatccccca ccgcaccctc
    17761 cgcagtgtcc cccgcgttcg acggctccac cagcctgctg tccccggaca actgcctggg
    17821 cctgaacggc cattccagag ccaccctcga cggcgcgtcc cgcagctggc tgctggcccg
    17881 gctccccgcc cgggtggcca ccgcgatggc cgccgccacc cactgggagc tctacggcac
    17941 ccgcggcctg ctggtggtgg cgtgcggtga ggacgcccgc aggatgggtt tctcggtgga
    18001 gtccgtccgc cgcgaggccg ccgccccgac caccccgtac gaggtgctga ccgcccggga
    18061 ggcgcggctc gcggccacct gcccggacgc cgaacgggag cgtctcatca cccgtttctg
    18121 ggtccgcaag gacgccgcca tgcaggccgt cggccgcggt ctgtccatcg ctccggagcg
    18181 tatcgaggcc ggctttccca ccgaccacgg cacggtcagc gtgccgggcc cgtacggcct
    18241 ggaagtcccc gtttcggtaa ggaacttcgc cttcgcggcc tcttacgagt tcgcggtggc
    18301 caccgctgaa ccccttccga tcgccccttc cttcgcctat tcgggcacgt aattgcccgt
    18361 ttcccgcgca ggtggcgcgg ccacggcgaa ttccgtgctc ctggcctgaa ttcacgcctt
    18421 gacagcggcg gccgcgggcg acggcacggc aatggcccag ccgggtgaaa cgcacgcatg
    18481 tcgcgcttcg ccggttgggc gaaaaccata ttgccgggtt agttggtgcg tgcccaccgg
    18541 tcgtggcgag cacgcggtca cggcgttgcc ggagcacagc ggaggaatcc cgtgatgccg
    18601 tcgccccacg ccaagcgttc cgtcgtgacg atcctgtccg tgctgctggc ggtgctgagc
    18661 gtcctcggcc tcgccgcccc cgccgtggcg accggtgctc ccctcggttc cccggtgccc
    18721 gactgggagc gcatcgccgc ctgcgagagc aacggccgct ggcacatcaa ctccggcaac
    18781 ggctaccacg gcggcctgca gatcgacccc gccacctggc gcgcgtacgg cggcggccag
    18841 tacgccccgc gcgccgacct cgccagccgc gacgagcaga tctccgtcgc ccggcgcatc
    18901 gtccgcgacc gcggcatgtc cgcctggccc aactgctcct acaccaccgg cacccgcgcg
    18961 gtcccgcagc aggctccgcc cgccgcccac tcctatgtcg tacgccccgg cgactgcctc
    19021 tccgccatcg ccgaacgcac cggcacccct ggtggcgcca aggccctcta ccacctcaac
    19081 aagcaccgtc tccccgacgg cgccgatcgc atctacccgg gccagcggct gcgcctgcgg
    19141 gcgtgagccc gggccggacg cgccgggggc cgtgggggtt cagcgcaccg cgaccaccac
    19201 gtggctgttg ccgaactgcc agaccggccc ggcgtggcgg aagccggcct cgcgcagcag
    19261 cgtgaggtgg gcggagaggg tgaggtgttc gccctcgctg gcgggcagcg ggcgggtgcg
    19321 gcgttcggcg agcaggccgg cgagtgcggg gtcggcgtgt gcggcggccc accaggagtc
    19381 ccagtcctcg tgggagcgga cgcgccggcg ttcggcccgg cggcggccga cggcgcgggc
    19441 gatctcgcac agccgtccgg cgtcctgccg gaggtggtcg ccgttgacca ggacgccgcc
    19501 ggggcgcagg cggtcggcca ggtcgcggta gacgcggcgc agggccgcct cgccgaggta
    19561 gtgcagggcg gtggtggaga ccgcggcgtc cagggggcgg tccagggcca gggcgccgag
    19621 ccagccgggg cggccgatca cggcctcgac gaagcggacg gccgggccgt agtacgcgcg
    19681 ccccagcccg agcaggagag ggtcggcgtc gacggccacg atcgcggcgt gcgggagccg
    19741 ggccgccagc cgggccgcca gggcgcccgg gccgcagccg aggtcgacga ccagcggttc
    19801 ggcaaggccg gcggtggtgt gttcgacgac gtcggcgatc accgtgagcc gctcgtcgcg
    19861 gtcgaccgcg tagtgctgct gctggtcctc ccagcgccgc acccagcgtg ccgccgtggc
    19921 gacgccgacg ctcgtgccgc cccgtacctc tgtcgttccg ctcgtccccg acaccacgcg
    19981 ccacccctgc tcgcaccgat gattgtgaaa atcattgcag actggtgagg gtggagacca
    20041 gcgcgtcgat ctcctccgga gtgttgtgga cgtgcaggct cacccgcacg gagccgtcct
    20101 ccccgcccgc gggcgcgccg gcctggcagt ggtggtcgga gcggaccatg aagccgtggc
    20161 tgtagaggat gaagccgagg tcggtggagc tgatggcgcg gtgccggaag gtgacgatgc
    20221 tgcggcggcg ctggacccgc gaggcggcgg acaggctctc ccggcagccg aggacctcgt
    20281 acgcgtcgag ccggccgagg ccgtcggtca gccgggcggc cagcgccacc gtccagcgct
    20341 cgatccggtc cgtgcccgcc gcgtccagcc agtcgagcgc cgccgccagg ccggcgatcc
    20401 cggcggtgtt gggggtgccc tgccagccgc cggggcggaa gcgggggccg cgcaggccgc
    20461 gggcccagac ggcgccggtg cccggcaggg cgagcgcctt gtgcccggag aacaccacga
    20521 agtcgacgtc cagccggtcg gtggagaccg ggaggtggcc gacgctctgg gcggcgtcga
    20581 ggcagatcgg cacggcgggc ccggccacct cgcggaggcg gtggacgttc atgtcggccc
    20641 cgtacacgtg gtgcacgtgc gtggcggcga tgaaccgggt gcggggggtg agctgcgccg
    20701 ccagcgccgc cgggtcgtag tcgccggagc cctcctggca gggcagcgcg cggacgcgga
    20761 cgccgatgcc gcgccgcgcc agcaggtccc gggcctccag ccacggcgcc aggttcgccc
    20821 ggtggtcggc gaacgggacg acgatctcgt cgccgtcggt caggaacgtg gtcagccagt
    20881 cccgggcgac ggcgcgcagt ccctcggtgg tgccgctggt gaagtgcacg gcggagcgct
    20941 cgggacgcgg gtcgcgcagg aaggacttga cgcggtcgcg ggccgcctcc accagggcgg
    21001 tcgtggcgtt ggcccagggg taggtgccgc ggcccgcgtt ggcgttggag gtcgtcaggt
    21061 aggagagcac ggcgtccagg acggcctgcg gcttctgcga ggtggccgcg ctgtccagat
    21121 aggcgagtcc ggggtgggcc gtgatgatcg ggaactgggc gcgcagcgga cgctgccacg
    21181 cccgcagcgc caccaggtcg tcgtccggcg tctgccgccg gggcgggtcc tccacgggac
    21241 ggctcatgtc agtcccgcac caggggagcg cccgcgtcgc gccaggcgat gatgccgccg
    21301 gccaggctgc ggacgtcggg atggcccatc cgcgtcagca gcgccgcgta ccgtacggac
    21361 ttctcgccga ccggacaggc cagcaggacc ggctgccgct tgctgaacgg cagcccgccg
    21421 cgcaggagtt cgtcgaacag ttcgtccacg atgttgatcg agccgtcgat gtgcagggcg
    21481 gcgtaggcga aggggccgcg gaggtcgacc accagcgggc gttcggcggc gatccacttc
    21541 cgggcgtcgg tggtgtcgat gacggtcgtc gcccgtatct cggcgtcggt gagggtggcc
    21601 accgagttcc gcgcgggcgg ccggcccagc agctccggcc ggcgttcgcg gacgtagccg
    21661 aggtagctct cgacgcggtc gcagacgatg aagacggcgg tccgccggcg cccgtccgcg
    21721 cccgccgccc cggccgactc cgcgtccagc ggccgcagat ggcgcaccgc gccgtggtac
    21781 gccgcgccgc ccgtgggccc ggcgagcagg ccgcagcggc ggatcagcgt cagcattccg
    21841 tccagcgcgt cgtcggcggc gaccgcctcg atcgtgtcgt aggtggcggg gtcgaagagg
    21901 ccgacctcgt gcacctcgtc gagggtgcgg atgcccggga tgaagtcgga cttctcaccg
    21961 accagtccga cgacccggac cgcgggatcg tgcgcccgca gcgccctggc cacaccggtg
    22021 gacgaaccgg cggtgcccac acaggcgacg aaccagtcgg gggcccggcc gtccaggtcg
    22081 gcgatgatct ccgggccggt gccggccgcg tgcgccgcgg tgttcaggtc gttgaagtac
    22141 tggtcggtgt gcaggctcgg ccggccgggc cgggtcagct cctggtggaa gagggtgagc
    22201 gggtcctcgg tgtcggtcgg gtcgaggcac tcgctccggc cgggcagctc ctcgatctcc
    22261 gcgcccagca gcaggagcag ctccttgatc tccggcaccc gcatccggtt ggtgacgctc
    22321 ttgaacggca ggccgtgcat ccccgcgatg acggccagcg ccttggcggt gttcccgctg
    22381 gacagctcga cgatcgtcgc gccgcggcgc accgcgtcgg gcaggccggg ccgggccatg
    22441 ttccaggccg cccggtcctt gaccgagccg aaggggttga gcatctccag cttcgcgtac
    22501 agatcgatgt ggcgcaggcc gtgcacggcc gggtcgatgc gcacgagcgg ggtgtcgccg
    22561 atggcgtcgg tgatgctgtc gtacctcatg ccgtgagtcc cccagaaggt gtgagcggcc
    22621 agtactgctc gtcgaggcac cagcgccagg agccgtcctc ctcccaggcg gcgaccttgt
    22681 gc
//
