LOCUS       NZ_CP021070            20636 bp    DNA     circular CON 04-JUN-2024
DEFINITION  Mesorhizobium sp. WSM1497 chromosome, complete genome.
ACCESSION   NZ_CP021070
VERSION     NZ_CP021070.1
KEYWORDS    RefSeq.
SOURCE      Mesorhizobium sp. WSM1497
  ORGANISM  Mesorhizobium sp. WSM1497
            Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
            Phyllobacteriaceae; Mesorhizobium.
REFERENCE   1  (bases 1 to 6666492)
  AUTHORS   Brewer,R., Haskett,T.L., Ramsay,J.P., O'Hara,G.W. and Terpolilli,J.
  TITLE     Complete genome sequence of Mesorhizobium sp. WSM1497
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6666492)
  AUTHORS   Brewer,R., Haskett,T.L., Ramsay,J.P., O'Hara,G.W. and Terpolilli,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-APR-2017) School of Biomedical Sciences, Curtin
            University, Kent street, Bentley, WA 6102, Australia
REFERENCE   3  (bases 1 to 6666492)
  AUTHORS   Ramsay,J.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAY-2016) School of Biomedical Sciences, Curtin
            University, Kent Street, Bentley, WA 6102, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 18-FEB-2017
            Assembly Method                   :: SPAdes v. 3.10.0
            Assembly Name                     :: WSM1497_pacbio
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 350.0x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001672455.2-RS_2024_06_04
            Annotation Date                   :: 06/04/2024 02:19:27
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,874
            CDSs (total)                      :: 6,812
            Genes (coding)                    :: 6,671
            CDSs (with protein)               :: 6,671
            Genes (RNA)                       :: 62
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 141
            CDSs (without protein)            :: 141
            Pseudo Genes (ambiguous residues) :: 0 of 141
            Pseudo Genes (frameshifted)       :: 86 of 141
            Pseudo Genes (incomplete)         :: 87 of 141
            Pseudo Genes (internal stop)      :: 20 of 141
            Pseudo Genes (multiple problems)  :: 46 of 141
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:49:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6164496
            Orig. end                         :: 6185132
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021070.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20636
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hserlactone"
                     /region_number="10"
                     /rules="Autoind_synth"
                     /tool="antismash"
     cand_cluster    1..20636
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20636
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10636](-)"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10636)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
     gene            complement(126..860)
                     /gene="queE"
                     /locus_tag="A9K65_RS30185"
                     /old_locus_tag="A9K65_030180"
     CDS             complement(126..860)
                     /EC_number="4.3.99.3"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="queE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533305.1"
                     /locus_tag="A9K65_RS30185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030180"
                     /product="7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_064993285.1"
                     /sec_met_domain="QueE (E-value: 2.7e-43, bitscore: 146.7,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTRPAIRVSEIFGPTIQGEGVLIGLPTVFIRTGGCDYRCSWCD
                     SLHAVDNQFRDEWKMMPVDAVWQNVVALSGARPVMVSLSGGNPAIQPFGGLIERGHAEG
                     YRFALETQASVAKDWFAELDVLVLSPKPPSSEMRTDWVAFEACIEAAREKPQVVLKLVV
                     FDESDYAFAKDAAARFPRLPVYLQPGNHTPPRRGEEDAAVDLAGIMRRMEWLIEKVTRD
                     RWFEARVLPQLHVLLWGNKRAV"
     gene            complement(857..1213)
                     /gene="queD"
                     /locus_tag="A9K65_RS30190"
                     /old_locus_tag="A9K65_030185"
     CDS             complement(857..1213)
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTPS"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003528526.1"
                     /locus_tag="A9K65_RS30190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030185"
                     /product="6-carboxytetrahydropterin synthase QueD"
                     /protein_id="WP_013533306.1"
                     /sec_met_domain="PTPS (E-value: 3.3e-33, bitscore: 112.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRITKEFHFSASHQLTSLPPEHQCARLHGHNYIVVVELSAKELN
                     SHGFVRDYHDLAPLKHYIDESLDHRHLNDALAHEQVTAEYLARHFYEWCKARLPETAAV
                     RVSETPKTWAEYRP"
     gene            complement(1213..1911)
                     /gene="queC"
                     /locus_tag="A9K65_RS30195"
                     /old_locus_tag="A9K65_030190"
     CDS             complement(1213..1911)
                     /EC_number="6.3.4.20"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533307.1"
                     /locus_tag="A9K65_RS30195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030190"
                     /product="7-cyano-7-deazaguanine synthase QueC"
                     /protein_id="WP_064993286.1"
                     /sec_met_domain="QueC (E-value: 1.7e-57, bitscore: 192.8,
                     seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLVICSGGLDSVSLAHKVAAEHELVGLLSFDYGQRHSKELKFA
                     AMCAQRLDIAHQIIDIRQIGRGLCGSALTDGVDVPDGHYAEDTMKITVVPNRNAIMLAI
                     AFGLAAAQQLEAVGMAAHGGDHFIYPDCRPAFIEAFQTMQNRALDGDAQIRLYTPYVNL
                     TKADIVGDGARHGTPFAQTWSCYKGGERHCGRCGTCVERREAFHLAQHADPTDYEDTDF
                     WLEALRRRSA"
     gene            2364..2753
                     /locus_tag="A9K65_RS30200"
                     /old_locus_tag="A9K65_030195"
     CDS             2364..2753
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533308.1"
                     /locus_tag="A9K65_RS30200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030195"
                     /product="hypothetical protein"
                     /protein_id="WP_064993287.1"
                     /transl_table=11
                     /translation="MASQELDWAIFQMAVESVRSLSSSFSERAAEIAARSQGTLVFDVR
                     VDDDPQVQRIAAIRYRGEQTGVVALDRQGLLTHYCMVNDTFSDLMAPLENWTSMPLSTQ
                     AKIDITVHAGPFLAALRNAGHLLGS"
     gene            complement(2963..3217)
                     /locus_tag="A9K65_RS30205"
                     /old_locus_tag="A9K65_030200"
     CDS             complement(2963..3217)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533309.1"
                     /locus_tag="A9K65_RS30205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030200"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_064993353.1"
                     /transl_table=11
                     /translation="MKDSRIPEPVLTAMSAGTHITRAYREHLGYSVEDLAVACGLAAEE
                     ILNIESGLRYNKGYRDRIAKSLSLPAGILETEADILDAA"
     misc_feature    3646..3661
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.42"
                     /tool="antismash"
     gene            3740..4705
                     /locus_tag="A9K65_RS30210"
                     /old_locus_tag="A9K65_030205"
                     /pseudo=""
     CDS             3740..4705
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007533501.1"
                     /locus_tag="A9K65_RS30210"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="A9K65_030205"
                     /product="glycosyltransferase family A protein"
                     /pseudo=""
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.8e-23,
                     bitscore: 80.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASFTIVIPFYQKKAGILRRSLQSVFEQTYTGFEVLVIDDESPLP
                     AEVELEALDADQRSRITVIRQANAGPGGARNTGLENVSPSTRLVAFLDSDDTWLPHHLH
                     NAFESMLCFGGDCYWASIQASEEFYYHLAISELAGADG"
     misc_feature    3766..3779
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.63"
                     /tool="antismash"
     misc_feature    complement(3767..3780)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.28"
                     /tool="antismash"
     misc_feature    complement(3767..3781)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.4"
                     /tool="antismash"
     gene            4702..>4883
                     /locus_tag="A9K65_RS30215"
                     /old_locus_tag="A9K65_030210"
                     /pseudo=""
     CDS             4702..>4883
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018012133.1"
                     /locus_tag="A9K65_RS30215"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="A9K65_030210"
                     /product="polysaccharide pyruvyl transferase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTPYHWESSHGNLVTTSISGYGTFCCLDSGRCTNKQCSWASARS"
     gene            5304..5711
                     /locus_tag="A9K65_RS30220"
                     /old_locus_tag="A9K65_030215"
     CDS             5304..5711
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A9K65_RS30220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A9K65_030215"
                     /product="hypothetical protein"
                     /protein_id="WP_064993288.1"
                     /transl_table=11
                     /translation="MLLVRIPVISIGLGCWGLPGLIFSRVLTGLFSAVVNMVVVERLIN
                     VSVRAQLLANFRALASSAVLAAGVTLADHCIGAQTTQTGLVLQLAVLICLGGTLYCGFS
                     LFLWIVMGRPDGPETEVRKLAFKVLSKVSHA"
     gene            5744..6756
                     /locus_tag="A9K65_RS30225"
                     /old_locus_tag="A9K65_030220"
                     /pseudo=""
     CDS             5744..6756
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533312.1"
                     /locus_tag="A9K65_RS30225"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030220"
                     /product="polysaccharide pyruvyl transferase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPGAQELELIAALQDITHDCLKMFVRPDEPIAILDFPDIKNCGDS
                     AIWLGLPI"
     gene            6753..7562
                     /locus_tag="A9K65_RS30230"
                     /old_locus_tag="A9K65_030225"
     CDS             6753..7562
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533313.1"
                     /locus_tag="A9K65_RS30230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030225"
                     /product="galactosyl transferase"
                     /protein_id="WP_064993289.1"
                     /transl_table=11
                     /translation="MTAVTFIVPVRHQDNARDWGLLKRNLAQTVTSIANQTNPDWRGIV
                     VANDGADLPVMPDKFSVVRVSFPPNDIHERGDATENDFLDSFRADKGRRVLAGMLNAAG
                     SRFFMIVDDDDLVSSRIVQYASKHPNENGWRIDKGYRWDDGGNVLLCRDQFSHYCGTSL
                     IIRSDLYGLPAKIEDAPIEWIKDTLGSHVRIAPALAKRGTPLNCLPFRAAVYRVAHQGS
                     HNKTPSLMQMYFVSRSALKRPFRVARNLAGLRLLSARHRKEFFGRPE"
     misc_feature    complement(7641..7655)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    7912..7925
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.15"
                     /tool="antismash"
     misc_feature    7989..8003
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 21.84"
                     /tool="antismash"
     misc_feature    complement(8170..8185)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.2"
                     /tool="antismash"
     gene            8220..9443
                     /locus_tag="A9K65_RS36190"
     CDS             8220..9443
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A9K65_RS36190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_224655955.1"
                     /transl_table=11
                     /translation="MKLAGKTVVVTGVCSGVGAEVARLARCEGVRLIGVDLEDPVVMLD
                     AFFRIDQDSPEEIDAALTQFPERIDGLVNAAGVSGTLDRDIVARVNYLGIRHLSHALAF
                     RMPEASSIVNFACLHDPEWPKRVDLHKELAATQSFTDGLAWPAASPVPQEPAIAISGAS
                     IDWIQLAGGLIFAALMAYPPAKTAAGSSDLTATPFDLTIAKWMRWRTIHKRAQGNPYMR
                     SSPKETATAAIPIHRVHPPSFWKGMILAATVIVLVPSSQVSAKGKGQTVHHIDQAASVG
                     WERKKMEELPAGTKFNHANRDGVWGGRGQSGHTGDAIWMTSENDVNTARGYAGSSGKYF
                     VVEAKEPLKLAVMDEQGNQVFPDELGAWAPLAQRYGLDGVKTEYGSSYEVILFHRSKIA
                     PVEERGFD"
     gene            complement(10001..10636)
                     /locus_tag="A9K65_RS30245"
                     /old_locus_tag="A9K65_030240"
     CDS             complement(10001..10636)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533316.1"
                     /locus_tag="A9K65_RS30245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030240"
                     /product="acyl-homoserine-lactone synthase"
                     /protein_id="WP_064993291.1"
                     /sec_met_domain="Autoind_synth (E-value: 6.6e-46, bitscore:
                     154.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMQLITPELYDEFSSELKEMYGLRHRVFKERLDWDVQTEEELETD
                     AYDGLRPVYLLLKGSDWRIRGCVRFLPTTGPTMLRDTFPMLLGETAAPASARIWESSRF
                     ALDLPASTPKAGGLAQATYELFAGMIEFGLSNELTRIVTVTDTRMERILRLATWPLARI
                     GHPKAVGNTEAVAGFLEVSHASLMRIRWRGRLNGPVLWQPVLGLSAYA"
     misc_feature    complement(10715..10732)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            complement(10731..11456)
                     /locus_tag="A9K65_RS30250"
                     /old_locus_tag="A9K65_030245"
     CDS             complement(10731..11456)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533317.1"
                     /locus_tag="A9K65_RS30250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030245"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_064993292.1"
                     /transl_table=11
                     /translation="MHRVFENFLEQLSESVDAVDLCETMASAAAALDFPLFAYFSCPSA
                     SGRKPRLISNYPPSWTSRYMQLRYHRHDPVILRGLQGWDTFDWGVDLARQHLPASQQRI
                     LEEAARFGIRSGLTMSIHDHRGRFAALTLASDQPRPPLLRSLTRYEQALQLVAISFHIF
                     ARRRLAEDCVVNGVILTPREFECLKWAADGKSAWDISQILSVSKRTVTFHLENAKAKLG
                     VRTINQAVARLASSRHSRS"
     gene            complement(11616..12479)
                     /gene="panC"
                     /locus_tag="A9K65_RS30255"
                     /old_locus_tag="A9K65_030250"
     CDS             complement(11616..12479)
                     /EC_number="6.3.2.1"
                     /GO_function="GO:0004592 - pantoate-beta-alanine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533318.1"
                     /locus_tag="A9K65_RS30255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030250"
                     /product="pantoate--beta-alanine ligase"
                     /protein_id="WP_064993293.1"
                     /transl_table=11
                     /translation="MSVPIVRSTAELRAVTARWRRSGAKVALVPTMGALHEGHLSLVRA
                     ALQKADRVVVTLFVNPKQFNSATDLDAYPRTENQDAARLAPLGVHLLYLPDAEEMYPPG
                     FATSISVSGISEGLCGSFRPGHFDGVATVVSKLFLQTGADLACFGEKDFQQLQLVRRMV
                     GDLDIPITILACPTIREADGLALSSRNLRLSPAQRAIAPKLAAVLLGVADRLARGAPVL
                     PTLAEARAAILAAGYREVEYLELRREADLQPLTSLDQPARLLVAAWLGDIRLIDNIGMS
                     PIGATN"
     gene            complement(12476..13312)
                     /gene="panB"
                     /locus_tag="A9K65_RS30260"
                     /old_locus_tag="A9K65_030255"
     CDS             complement(12476..13312)
                     /EC_number="2.1.2.11"
                     /GO_function="GO:0003864 - 3-methyl-2-oxobutanoate
                     hydroxymethyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533319.1"
                     /locus_tag="A9K65_RS30260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030255"
                     /product="3-methyl-2-oxobutanoate hydroxymethyltransferase"
                     /protein_id="WP_064993294.1"
                     /transl_table=11
                     /translation="MSATGETKAITPPDISARKGQAPLVCLTAYTTPIARLVDPHCDVV
                     LVGDSVGMVLHGLSSTLGVTLDMMIMHGQAVRRGLVRSLMVVDLPFGSYEESPVQAFGN
                     AARLMAQTGCAAVKLEGGEKMAETIRFLCARGIPVMAHVGLTPQAVNTLGGYRVQGRGE
                     DAERIRRDANAVTEAGAFSVVLEKVPEPLAKRITAEIAVPTIGIGASLACDGQILVSDD
                     MLGLFSSFRPKFVKRYAELGEQADAAIAAYAADVRRRCFPAAEHLYTHEARAGDVT"
     misc_feature    complement(13334..13349)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
     gene            13486..14448
                     /locus_tag="A9K65_RS30265"
                     /old_locus_tag="A9K65_030260"
     CDS             13486..14448
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533320.1"
                     /locus_tag="A9K65_RS30265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030260"
                     /product="hypothetical protein"
                     /protein_id="WP_064993295.1"
                     /transl_table=11
                     /translation="MNHQAKGTRKGRAAVKADEAKVDLIAVVVAVTDSDPCLLTIGNAD
                     TLPSGPYALEHRSLQSGLRGWVEQQTGHPLGYIEQLYTFADRDRIGAEPQERAISISYL
                     ALTRKEQAAGSASCGWRSWYEYLPWEDHRSGTPVVLDILRPRLSEWAEGASDATTRRER
                     LQRAAIAFGFDHRNWNEELTLQRYELLYESALIEEAGRGRDATPAVTSGKAMVADHRRI
                     LATGIARLRSKIKYRPVVFELMRPSFTLLQLQRTVEALAGRLINKPNFRRLVEQQELVE
                     ETGETSLETGGRPAKLYRFRHAVLDDRAGAGTKLPLARA"
     misc_feature    14480..14500
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.64"
                     /tool="antismash"
     gene            14513..15487
                     /gene="nadA"
                     /locus_tag="A9K65_RS30270"
                     /old_locus_tag="A9K65_030265"
     CDS             14513..15487
                     /EC_number="2.5.1.72"
                     /GO_function="GO:0008987 - quinolinate synthetase A
                     activity [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nadA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533321.1"
                     /locus_tag="A9K65_RS30270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030265"
                     /product="quinolinate synthase NadA"
                     /protein_id="WP_064993296.1"
                     /transl_table=11
                     /translation="MTGALPTAASLYERVRRVIPPVEWPAFTDDLEAILALKRDRNAVI
                     LAHNYQTPEIFHCVADIVGDSLALARKAATVEAQVIVVAGVHFMAETAKLLNPNKMVLI
                     PDLRAGCSLAESITAEDVRQLRQRYPGVPVVTYVNTSAAVKAESDICCTSGNARAVVES
                     LGVPRVIMVPDQYLAINVAADTDVEIIAWKGHCEVHERFTSTDIRELRDAHPGVIVLAH
                     PECPPEIVTQAEFSGSTAAMLDYVEREKPARVVLLTECSMSDNVAVAHPEIEFIRPCNL
                     CPHMKRITLANIRAALEENRHEVRIAAGIAERARHSVERMLSI"
     gene            15484..17031
                     /locus_tag="A9K65_RS30275"
                     /old_locus_tag="A9K65_030270"
     CDS             15484..17031
                     /EC_number="1.4.3.16"
                     /GO_function="GO:0008734 - L-aspartate oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008874737.1"
                     /locus_tag="A9K65_RS30275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030270"
                     /product="L-aspartate oxidase"
                     /protein_id="WP_064993297.1"
                     /sec_met_domain="DAO (E-value: 8.4e-09, bitscore: 34.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDVHDIGGAPVIIGSGLAGLMTALHLAPEPVVLLSNAGLGTGA
                     CSELAQGGLAASVGGEDSPELHLCDTLAAGDGLCDEATVRRVVRAAPEAIRTLERFGVA
                     FDRRADGALRLGLEAAHSQRRIVHAAGDATGRELVRALVAAARRTASITVLENVEARRL
                     VVEDGAIIAVVAAGCTGAIALPTRRAVLATGGIGALFSETTNPPGSCGQGLALAACAGA
                     EFADLEFVQFHPTALEGPRRPMPLVSEAVRGEGAVLVDEQGERFLGDTPGGELAPRDVV
                     ARAVWRQLALGRRVFLDARQCLGPRFDKRFPAIADLCRQAGIDPATDLIPVRPAAHYHM
                     GGVAVDAAGRSSIEGLWACGEVACTGLHGANRLASNSLIEAVVTASWVAESVADASHTR
                     RPRVCSAFVPQRPDASGIRPIVSAALGIVRDGETLRDGVATLLPVAAHDSAASDPAMVA
                     LMIAIAALRREESRGSHYRSDFAGRDADARQSRLTLRSAIQTAVALSWRAPMRSTLT"
     gene            17028..17906
                     /gene="nadC"
                     /locus_tag="A9K65_RS30280"
                     /old_locus_tag="A9K65_030275"
     CDS             17028..17906
                     /EC_number="2.4.2.19"
                     /GO_function="GO:0004514 - nicotinate-nucleotide
                     diphosphorylase (carboxylating) activity [Evidence IEA]"
                     /GO_process="GO:0019363 - pyridine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="nadC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533323.1"
                     /locus_tag="A9K65_RS30280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030275"
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="WP_064993298.1"
                     /transl_table=11
                     /translation="MKFSPLPSTLIEPIVRGALLEDLGRCGDLTSEAVIPRDRTATLVL
                     KSRQTGIVAGLDLAAFAFMLVEPAIDMQIWRVDGSDVAGGEIIAMLCGPARGLLTAERT
                     ALNFLCHLSGIATATAAMVEAVRGHKARIVCTRKTTPGLRALEKYAVRVGGGANHRFGL
                     DDAFLIKDNHIAIAGDIRTTIERARAAAGHMVKIEVEVETLEQLDTALTLGVDAVLLDN
                     MSVEDLARAVAMVGGRAVTEASGRVTPKMAPAIAATGVDLISVGWLTHSAPILDIGLDM
                     PTRGNISTHLN"
     gene            18097..19107
                     /gene="bioB"
                     /locus_tag="A9K65_RS30285"
                     /old_locus_tag="A9K65_030280"
     CDS             18097..19107
                     /EC_number="2.8.1.6"
                     /GO_function="GO:0004076 - biotin synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0009102 - biotin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bioB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF06968"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013533324.1"
                     /locus_tag="A9K65_RS30285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030280"
                     /product="biotin synthase BioB"
                     /protein_id="WP_064993299.1"
                     /sec_met_domain="PF04055 (E-value: 1.5e-14, bitscore: 53.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="PF06968 (E-value: 6.3e-20, bitscore: 69.7,
                     seeds: 824, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEMNEECDSDFATQSMEAALARWSRKEAEAIYGMPFNDLLFLA
                     QTVHRQNFDRNRVQLSRLLSIKTGGCPEDCGYCSQSAHHQTGLKASKLMEVKHVVEEAT
                     KARDAGATRYCMGAAWRSPKERDMDAVLAMIEGVKALGLETCMTLGMLDLSQAQRLKAA
                     GLDYYNHNIDTSARYYGKVVSTRTFADRLETLGRVREAGIKVCCGGIVGMGEEKADRMD
                     MLVTLANLPEPPESVPINMLIPIRGTPLADAEPIDPIDFIRTIALARIMMPKSDVRLSA
                     GRTAMSDETQALCFFAGANSIFVGDTLLTADNPGEDKDTRLFRRLGIEPMRGEAK"
     misc_feature    18105..18116
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            19104..20246
                     /locus_tag="A9K65_RS30290"
                     /old_locus_tag="A9K65_030285"
     CDS             19104..20246
                     /EC_number="2.3.1.47"
                     /GO_function="GO:0008710 - 8-amino-7-oxononanoate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009102 - biotin biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (30-370). E-value:
                     1.9e-46. Score: 150.8. Matches aSDomain:
                     nrpspksdomains_A9K65_RS30290_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109: 8-amino-7-oxononanoate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006333932.1"
                     /locus_tag="A9K65_RS30290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A9K65_030285"
                     /product="8-amino-7-oxononanoate synthase"
                     /protein_id="WP_064993300.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.1e-44, bitscore:
                     150.7, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.3e-05,
                     bitscore: 23.1, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEPPLARFEATLQGLARKDRLRALAPRVGLDFSSNDYLGLAAFK
                     RLGDAVAAAIERGTPVGATGSRLLRGNAPEHEALESDAAAFFGAERALFFGSGYMANFA
                     LLSTLVKKGDLLILDELAHASMHEGARAGRAEFRLVAHNDIDAFEDAIRRWRAEGGIGR
                     IWIGVESLYSMDGDCAPMESLVELADRHEAFILVDEAHATGVWGPGGRGLAAAFEGRDN
                     IVALHTCGKALGASGALVTGPRVLCDYIVNRCRPFIYATAPSPLMAVAAREALAMLVDE
                     PMRRVDLHEHVAFASRQLAEHCGAKPSGSQIHPFVIGDVARTMAVAAALQARGFDLRGI
                     RPPAVPEGTSRLRISLTLNVGKADIRVMVETLAEVLATTA"
     aSDomain        19194..20213
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A9K65_RS30290_Aminotran_1_2.1"
                     /evalue="1.90E-46"
                     /label="A9K65_RS30290_Aminotran_1_2.1"
                     /locus_tag="A9K65_RS30290"
                     /protein_end="370"
                     /protein_start="30"
                     /score="150.8"
                     /tool="antismash"
                     /translation="LDFSSNDYLGLAAFKRLGDAVAAAIERGTPVGATGSRLLRGNAPE
                     HEALESDAAAFFGAERALFFGSGYMANFALLSTLVKKGDLLILDELAHASMHEGARAGR
                     AEFRLVAHNDIDAFEDAIRRWRAEGGIGRIWIGVESLYSMDGDCAPMESLVELADRHEA
                     FILVDEAHATGVWGPGGRGLAAAFEGRDNIVALHTCGKALGASGALVTGPRVLCDYIVN
                     RCRPFIYATAPSPLMAVAAREALAMLVDEPMRRVDLHEHVAFASRQLAEHCGAKPSGSQ
                     IHPFVIGDVARTMAVAAALQARGFDLRGIRPPAVPEGTSRLRISLTLNVGKADIRVMVE
                     "
     misc_feature    complement(20288..20299)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     misc_feature    20310..20325
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.03"
                     /tool="antismash"
     misc_feature    complement(20571..20585)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
ORIGIN
        1 gggggcttac ccaagccata gcagcggcgc gacaggcgca cgggctctag ttccgtccgg
       61 cgctgacggc gccagattct ggccgaggat aagattggtg cagttcccac accggcgagc
      121 gagacctaga cggccctctt gttaccccag agcagaacat gcagctgcgg caatacgcgg
      181 gcttcgaacc atctgtctcg cgtcaccttt tcgatcagcc actccatgcg cctcatgatt
      241 ccggcaaggt cgacagctgc gtcttcctcg ccacggcgcg gtggcgtgtg attgccgggt
      301 tgcagataga ccgggagacg tggaaatcgg gcggcggcgt ctttggcgaa ggcgtagtca
      361 ctctcgtcga aaacgacgag cttgagcacg acttgcggct tctcccgcgc cgcttcgatg
      421 caagcctcga atgcaaccca atcggtcctc atttcgctcg acggcggctt tgggctgagg
      481 accagtacgt caagctcggc aaaccagtcc ttggccaccg aagcttgggt ttccagcgcg
      541 aagcggtaac cttcagcatg gccccgctcg atcaggccgc cgaagggctg aatggcgggg
      601 ttgccgcccg acagggacac cataactggc cgggcgccgg aaagcgcaac cacgttttgc
      661 cacaccgcgt ccactggcat catcttccat tcatcgcgga attggttgtc aaccgcatgg
      721 aggctgtcgc accaggaaca gcggtagtca cacccgccgg ttctgatgaa gacggtcggc
      781 aaaccgatga gcacgccctc gccctggatc gtcggcccga atatctcgct gacccggatt
      841 gcgggccgcg tgtcggtcac ggccggtact ccgcccaggt tttaggggtt tcgctcaccc
      901 tcacggcggc ggtttccggc agccgtgcct tgcaccattc atagaaatgc ctggccaggt
      961 attccgctgt gacctgctca tgcgcgagcg cgtcgttgag gtgccggtgg tccaagctct
     1021 cgtcgatata gtgtttgagc ggcgccagat cgtgatagtc gcgcacaaag ccgtgcgagt
     1081 tcagctcctt ggccgagagc tccactacga cgatgtagtt atgcccgtgc agtcgcgcgc
     1141 actggtgctc gggtggcaag gaggtgagct gatgcgaggc cgagaagtgg aattccttgg
     1201 taatgcggaa catcaggcgc tccgcctccg cagcgcctca agccagaaat cggtgtcctc
     1261 atagtcggtc gggtcggcgt gctgcgccag atgaaacgct tcgcgccgct cgacgcaggt
     1321 cccgcaccgt ccgcagtgac gttcgccgcc cttgtagcag gaccaggtct gcgcaaatgg
     1381 ggtcccgtgc cttgctccat cgccgacgat gtccgccttg gtgaggttca cataaggcgt
     1441 ataaagacgg atctgcgcgt ctccgtcgag cgctcggttc tgcatcgtct ggaaagcctc
     1501 gatgaaggcc ggacggcagt ctggatagat gaaatggtct ccgccgtgag cggccatccc
     1561 cactgcttcg agctgctgcg cggcggcgag tccgaaggcg atggccagca tgatggcgtt
     1621 tcggttcggc accaccgtga tcttcatggt gtcttcggcg tagtggccgt ccggcacgtc
     1681 gacaccatcg gtgagcgcgg agccgcaaag gccgcggccg atttggcgga tgtcgatgat
     1741 ctgatgcgca atgtccaatc gctgcgcgca catcgcggcg aatttcagtt ctttgctgtg
     1801 ccgctggccg tagtcgaagg acagcagccc gacaagttcg tgctccgctg ccactttgtg
     1861 ggcaagggaa acggagtcca atccgccgga gcagatgacg agagtcttca tcgtggtatc
     1921 cttgttttga ccgggtaagg ctgcgaccgg agatttctct gcgctccccc tagcccagcc
     1981 agtcaacttt gtgaaccctg tggcgctgac tcgccgaggg tgcggctggg tcgcgacacc
     2041 gcgcagcctc cttaggtcaa tgttcaaacc cgggcatacg cttagaatca caaatgcgaa
     2101 gcctcgcgat atggcttggg aagaattccc gtactcgtgg gagagcggag gctgcggagg
     2161 ccacgcgctg cctaacaaga gcaagggagt gagcgtggtg ccgagaggta gttcagtggg
     2221 cgtgccccct cgcttcagca tcagtccgaa tcggacagca cgatgggcgg cagaaccccg
     2281 gttaggatcg gtcgtcagcc gacatctgtg aacaagccgc atgcgtcgtt gcaatcaccc
     2341 ctctactacg cgcaattgcc gacatggcct cgcaggaact ggattgggcg attttccaga
     2401 tggcggtcga aagcgtccgc tctctctcat caagtttcag cgaaagagcc gcggagatag
     2461 ccgcgaggag ccagggtaca ttggttttcg acgtgcgggt cgacgatgac ccgcaggtgc
     2521 agcgaatcgc ggcaatccgg tatcgaggcg aacaaactgg cgtggtcgcg ttggacaggc
     2581 agggccttct tacccactat tgcatggtga atgacacgtt ctcagatctg atggcgcctt
     2641 tggagaactg gacaagcatg cccctctcaa cgcaggcaaa gatcgatatc accgtccatg
     2701 ccggcccctt cctcgccgcc ctacgaaatg ccggtcatct gcttggcagt tagcgtgact
     2761 ggaatgcatg tgtgatcctg cattcccccc gaacgcgccg cgagcggcgc ccgagctagg
     2821 ctctccgggc gcgtatggca cctgctgctc gcgttggtga tatcctgggc aaacggacct
     2881 gtggcgcaaa cgctgggttc caacaatgcg aaaacgagag acctgtttcc cggcaaccaa
     2941 cgggaaaccg gccttccacc gatcaggcag cgtccaatat gtccgcctcc gtctcaagaa
     3001 ttccggcggg tagggacagc gattttgcga tccggtccct ataacccttg ttgtatctca
     3061 gaccggactc aatgttcagg atttcctcag cggcaagccc gcacgccact gccaggtcct
     3121 cgacggaata tccaaggtgc tcacgataag cacgggtgat gtgggtcccc gccgacatgg
     3181 ccgtcaacac cggctcggga atgcgtgaat ctttcataaa cacctcgaag aagagcaaag
     3241 atgcccggca cctcgggaga gttcctctgg acccggacag tcaaatgaat tgactcaatt
     3301 cagcctggag gtctggtgca tgaggcacct aagaccagcg gccggaggcg gtatatggtg
     3361 gctcaaccgg gtccgatcaa gtcgtaacaa actgaccgcc gcaacatggt ctgatcgact
     3421 gcgccgacca tgcccgcgcc acccagtggg gctgatcacc gccgacgttc cggggcagta
     3481 gttcggcttg ctcaaccctg gattcggtgt tcctgctggc ctgctagcca tgtcgaagca
     3541 gccgccccgg gccaacggga acgggcaaac gagagtgcgc ccgagacccg agctgattgg
     3601 tgccatagat gacgccacgc tcgccgcaga cggcctatcc acgccatgga tgatcatcat
     3661 ccatacaatc actttggcca accattgccg aatgcgttac tcgggcctcg cacagacctc
     3721 ccgaaggcat ggatgagaat tggcctcttt cacaatcgtc atcccttttt atcagaaaaa
     3781 agcggggatt cttcgccgtt cgctacagag cgtatttgag cagacttata cgggctttga
     3841 ggttctggtt atcgacgatg agtcccctct tccggctgag gtcgagctgg aagcgcttga
     3901 cgccgatcag aggtcgcgca tcacggtcat aaggcaggcc aacgccggcc ctggtggcgc
     3961 tcgcaacacc gggcttgaga acgtttcgcc ttcgacgcgt ctcgtcgctt tcctcgattc
     4021 agacgacacc tggctgccac atcatctgca caacgctttt gagagcatgt tgtgcttcgg
     4081 aggggactgt tactgggcct caattcaagc gagcgaagag ttctattacc acctcgcaat
     4141 atccgaactt gcaggggcgg acgggtgatt cgattggggg agcagccgct tgtcatcgaa
     4201 gttcctgacc ttgcaagcgc aatgctgaag gactggagct ttctccatct ttctggaatg
     4261 gtgatcggcc gtaccatctt caaaaaaatc cgtttcgacg ccactcttcg gcgcgccgca
     4321 gaggacgtgc ttttcttctg cgatacaatc ctcgcctctc ggcgcagcct gctctgcggt
     4381 gatccgggcg tcgtgcgcgg cttgggcgtc aatatctttc accgcatcga ccgcacatcg
     4441 cgccgcttcc tgcagcagca attcaacacc tgggcagcgc tcgacgcgct cgaagcttgc
     4501 tttgcctgac ggccagagga agttgagtca atcgccaccc tccaagggca gagcgcgtcg
     4561 ccaggcgctt tggagccagg ccggacttct tcgtcgcggc aaagtgccaa acgtcggcct
     4621 gctcgcgcgt tgggcgtggc gtgaccctga gttgctgctg acactgaggg aactcgggac
     4681 agctaagttt gcggaggcga aatgactcca tatcattggg aatcgagcca cggcaatttg
     4741 gtgacgacct caatctctgg ctatgggact ttctgttgcc tggattccgg gaggtgcacc
     4801 aacaaacaat gctcgtgggc gtcggcacgg tcctgaattc gggcctgctt ccgcgcggtg
     4861 tgcacaagct ggttgtggga agcagccgcg gggaaccgca gcttagtccc gatggctcgc
     4921 tcgacggctt gaaaagtcgc tttggtgagg tgctgaacgg aatccgcaaa gattatcttt
     4981 aagcaacggg acgctccagc aaatgtcgaa aatcagcgtg gcgtgctgct cgcggccaga
     5041 cgaggtcgcg cgattgaaga cacgcgatga caaagtccgc gagcagcgac tcgggccgga
     5101 aattccggaa ctccgtggtg ctgagacttg gcgagaggtg cgttggcggg tcccacgcaa
     5161 gtcacgccgt tctagcgcga ggaagctttg atcgcatcca tggcgagaca ggcgcggtgc
     5221 cgagcagttg ggcatagagg acaccgacag aatggggctg cagcctgggg cagacccgga
     5281 ccctgttcgt gcgtgataca cagatgcttc ttgtccgcat accggtgatt tcgatcggtt
     5341 tggggtgctg ggggcttccg gggctgatat tcagccgggt gctcaccggt ctgttcagcg
     5401 ctgtcgtcaa catggtggtg gtggagcggc tcatcaatgt ctcggtcagg gcgcagttgt
     5461 tggcgaattt cagggcgctc gccagctcgg ccgttctggc cgcaggtgta acgctcgccg
     5521 atcattgcat tggcgctcag accacgcaga ccggcttggt tctccaactc gccgtcctca
     5581 tctgcctcgg cggaactctc tattgcggtt tcagtctctt tctctggatc gttatgggcc
     5641 gtccggatgg gccggaaacc gaagtgagaa agctcgcttt caaggtgctg tccaaagtca
     5701 gccacgcgtg atctccagct cgtcaattca aaagagaggt acgatgccag gtgctcagga
     5761 actagaactg attgctgcgc tgcaggacat aacgcatgat tgcctaaaga tgttcgtcag
     5821 gcccgatgag ccgatagcga tactggattt tcccgacatc aagaactgtg gcgactcggc
     5881 aatatggctg ggattgccta tttgaaggat cgttacgcaa agcggccttc ctatgtctgc
     5941 acgacggacg atttttccca tgatgaactc aaggggacgg ctccgagtgg gcccatattt
     6001 atccatgggg gcggcaattt cggcgactta tgggtatctc accaggactt ccgggaacat
     6061 atactggagt tgtttcccga ccggcagatc gtccagtttc cgcaatcgat ccattacagc
     6121 tctccggaac ggcttgagca aagcagacgc gccattggcc gacataagaa cttcgtgctg
     6181 ctggtgcgcg acgaggaatc ccttctgttc gcccgggaaa agttcgattg ccaggtgcat
     6241 ctctgccccg acatggcttt ttgcatcggc agtgtgcagc ctgatgcgcc ccgcttcccg
     6301 gtgctcgcga tgcttcgcca ggacaaggag caggtcggag cggtcgattt ctctgtctat
     6361 ccccatatcc caagggagga ctggatcacc gagcgccact cgagggtggg cgttgcaaaa
     6421 gcgctcggtg cggcatctgc gttgctgcac ctcagcccct cagaagtgcg gttgcgcaaa
     6481 ctgaatgccg cggccaacaa ccgctttcga cgcggcatcc ggcagatttc ccgtggcaag
     6541 gccatcctta cggatcgcct gcatgtgcac atctgttcga ttctcatagg gcgcccccac
     6601 gcggtgctgg acaacaacta cggaaaaatt cgccggttca tgaacgcttt ttcagggggt
     6661 accgatctat cctacaaggc aatgtcgaat gacgacggca ttagatgggc aagagaacag
     6721 gcggttggca cagtcaaaga ctggagactg tcatgactgc cgtaacgttc attgttcctg
     6781 tcaggcatca ggataacgcg cgtgattggg gcctcctgaa gaggaacctc gcccaaaccg
     6841 tcacatccat tgccaatcaa accaaccccg attggcgagg catagtggtt gccaatgacg
     6901 gggccgatct tcctgtcatg cccgataagt tctcggtggt ccgggtgagc tttccaccga
     6961 acgacattca tgagcgaggc gatgcaactg agaacgactt tctggattca ttccgcgccg
     7021 acaaaggccg ccgtgttctt gccggcatgc tcaatgccgc tggcagccgc ttcttcatga
     7081 tcgttgacga cgacgatttg gtaagctctc gtatcgtgca gtatgcttct aagcatccga
     7141 acgaaaacgg ctggaggatt gacaaggggt atcgctggga cgatggcggc aatgttctgc
     7201 tctgtcgtga ccagttcagt cactattgcg gaacatcgct gatcattcgt tcggatctgt
     7261 acgggctgcc ggcaaaaatc gaagatgccc ccatcgaatg gatcaaagat acgcttggca
     7321 gccacgtccg tatagcacca gctctggcca agcgcggaac tcccttgaat tgcctcccgt
     7381 tccgggccgc tgtgtaccgt gttgcacacc aggggtcgca caataagact ccgagcctca
     7441 tgcagatgta tttcgtaagc agaagcgctc tgaagcgccc cttccgtgtc gcgagaaatc
     7501 tcgccgggtt gcgtctgttg tcagctcgcc acaggaaaga gttcttcgga cgaccggaat
     7561 agacgggcgg ctgcaaagtt gtagcagggc ttgagcaata ttggcgtttg cggctgcgct
     7621 ctacggcctt aacgcgcgag ttcgacatgc ctgattggtt gcctggcctg aattgcgtaa
     7681 cccattgtca gcccaggtaa gggaatcgac tcactatcgg tcaggggcaa ttcaggagaa
     7741 tcttggccac cgcttcagca tgagcggcca ttaggcgggg actctattct ccagcttctg
     7801 acatccgcaa aggagggtat cgcattcgcg atcgagggcc gaaggtctct cggtggcacc
     7861 ggctgcgcca aaccatacct tagcaagcca ggccgaagcg ctctgtcagt tggcatggct
     7921 tttgcgcttg aaccgtccaa gccgacgggc gctttgcatc tacggtatgg atgaacacca
     7981 tgcatagaat cagttttgtc gatcgtaccc gaaccgacat aagcgacagc acctgcggtg
     8041 catcggcccg tatcgctgct tcaatcgctg aggcacgaaa cgtccgagtc gggcaacggc
     8101 acgcccggga gtctgaggcg gcatcgagga gttcaaccaa tcggcgtcgg cggtcaagga
     8161 cgccgcgacc tgatcagaca ttcgagagcg ccgtcctttg cgaaaagatg gagaagccgt
     8221 tgaagcttgc cggtaaaacc gttgtcgtaa ccggtgtctg ctccggggtc ggcgccgaag
     8281 tcgcccgtct cgcccggtgc gaaggcgtgc gtcttattgg agtcgatctg gaggatcccg
     8341 tcgtgatgct ggacgcgttc tttcgcatcg atcaggattc tcccgaagaa attgatgcag
     8401 cgcttaccca gttccccgaa cgcatcgacg gcctcgtcaa tgccgcaggc gtctcgggca
     8461 cgctggatcg ggacattgtc gcacgcgtga attatctcgg gatacgtcat ctgtcacatg
     8521 cacttgcctt ccgaatgccc gaggcctctt cgatcgtgaa tttcgcctgc ctgcatgacc
     8581 ccgaatggcc caagcgggtt gatctgcata aggaacttgc cgctactcag agctttacgg
     8641 atggactggc ttggccggcc gccagcccgg tgccgcagga acctgctatc gctatttcag
     8701 gcgccagcat tgactggata caactggccg gcggcctgat cttcgccgcg ctcatggcat
     8761 acccgccagc gaagaccgcc gccgggtcat cagacctgac ggcaactcca ttcgacttga
     8821 cgatcgcgaa atggatgcga tggcggacaa ttcacaaacg agcacaagga aatccttaca
     8881 tgagatcctc accgaaagag accgccaccg cggccatccc gattcatcga gtgcatcccc
     8941 cgtctttctg gaaggggatg atccttgctg cgaccgtgat cgtcctcgta ccgagtagtc
     9001 aggtttcggc taagggcaag ggacaaaccg ttcaccacat agatcaggca gcctcagttg
     9061 gttgggagag gaagaagatg gaagaacttc cggcgggaac aaagttcaac cacgctaaca
     9121 gggatggggt gtggggcggt cgcgggcaaa gcgggcacac gggcgacgca atttggatga
     9181 cctcagaaaa cgatgtaaac acggcacgcg gctatgcagg tagttctgga aagtactttg
     9241 ttgtcgaggc gaaagagccc ctgaaattag cggtcatgga cgagcagggt aatcaagtgt
     9301 tccccgatga actaggcgca tgggctccct tggcgcagag atacggcttg gatggagtga
     9361 agacggaata tggaagctcg tacgaggtga ttttatttca cagaagcaag attgcacctg
     9421 tggaagaacg tggtttcgat tagcacagac gccagcgcac gacgccatcg agataggtgc
     9481 cgtcctcgtt gagggggatg aagtttgcga gttcggtcat ggtctgtgtc ctgagtgtgt
     9541 gtttcccgac gggaaagccc tttcgagcga agcctccccg gtctttccgg ggggatggcg
     9601 agagcccgcc ccactgcggc gggcgggact gtcaagtggc gtggtgcgga aggtggggga
     9661 ccttctcggt ccgctcgcgg actgggcaga agattttcca ccttcacggg ccgcttgacc
     9721 ggcccggccg gcgatgcccc ctcctcgtca tcgcgcagtg gcgcgctgca tcgcttcacg
     9781 taggtatcaa agccgtaagg ctgattcctt tagtagctcc gttggaaagc gcgcgggcgg
     9841 tgattgaggt cagcttcctg ttgcgcaccg ctcccttgct ggagccgcca gccttcgccg
     9901 caatatggac cccccggacc gtcgatagag gcctcatgtg agcttctgaa acgcctttgg
     9961 ccaacggcag cgcgatgacg ccttcaagcg tgggaagatc ttaagcgtat gccgacaggc
    10021 cgagaaccgg ctgccataat acaggtccgt tcaaacgtcc cctccagcgg atgcgcatga
    10081 ggctagcgtg cgaaacctcg agaaagccgg cgaccgcctc cgtgttgccc accgccttgg
    10141 gatgcccgat gcgcgccaac ggccaagttg caagacgcag gatccgttcc atgcgcgtat
    10201 cggtcactgt cacgatccga gtgagttcgt tcgacaagcc gaattcgatc atgcccgcga
    10261 atagctcgta ggttgcttgg gccagccctc cagccttggg cgttgatgca gggagatcga
    10321 gtgcgaaacg actgctctcc caaatgcggg cactcgctgg cgccgcggtc tcgccaagca
    10381 gcatcggaaa cgtgtcgcgc aacattgtcg gtcccgtcgt cggcaaaaaa cggacgcaac
    10441 cgcgaatgcg ccagtcggat cctttgagaa ggagatagac gggcctcagc ccgtcatatg
    10501 cgtctgtttc cagttcctct tcggtctgaa catcccaatc cagcctttcc ttgaaaacgc
    10561 gatgcctcag tccgtacatt tctttgagct cgcttgaaaa ctcatcgtag agctcaggtg
    10621 tgattagctg catcatttgt cgcctccgtg caggatgtgg tcccgccatc gaagagcaaa
    10681 gccgacaatc atgcagcctg tagaccttta caggtatccg cagaaaggaa tcaggatctc
    10741 gaatgtcggg aagaagccag ccgtgctacg gcttggttga tggttcgcac gccaagtttt
    10801 gccttggcgt tttccagatg gaaggtcacg gttcgtttcg agacgctgag aatctggctg
    10861 atatcccagg ccgacttgcc gtccgccgcc catttcaagc attcgaattc tcgcggggtc
    10921 aggattacgc cattgaccac gcaatcttcg gcgagcctgc gccgggcaaa tatatgaaag
    10981 ctgatcgcga ccagctgcaa tgcttgctcg taccgtgtca gtgaccgcaa gagaggcgga
    11041 cggggctggt cggaagccaa ggtcagcgca gcaaagcggc cgcgatggtc atgtatcgac
    11101 atggtcaacc cggaacgaat gccaaatcga gctgcttctt ccagaatccg ttgctgtgaa
    11161 gccgggagat gttgccgagc taaatccaca ccccaatcaa aggtgtccca gccttgaagc
    11221 ccgcgcagga tcaccggatc atgcctgtgg tagcgcaatt gcatatagcg cgatgtccag
    11281 gatgggggat aattcgaaat caagcgcggc ttccggccgg aagctgacgg gcaactgaaa
    11341 taggcaaaga gcggaaagtc taacgcggct gcggcagacg ccattgtctc acacagatcg
    11401 acagcatcga cgctttcgga gagttgctcg aggaaatttt caaacacgcg atgcatctgc
    11461 gctttgcata aacctccgtg ccgttgctcg gcgcagacct tcgtctaaat gattggcgat
    11521 ccattcgacg tttgcgagct ggtcggctta atcgcgggca ttgctctgct cctggtcaat
    11581 gagcctgttg tgcggcgatg cagcgccgcg agcctctaat ttgttgcacc aattggtgac
    11641 attcctatgt tgtcgataag ccgtatgtcg cctagccatg ccgcgacaag caagcgtgcc
    11701 ggttggtcaa ggctcgtcag cggttgcaga tctgcctcgc ggcgaagttc caggtactcg
    11761 acttcgcgat agccggcagc caggattgct gcgcgcgctt ccgcaagagt gggaaggaca
    11821 ggagcgccgc gcgcaagccg atcggccacc cccagcaaga ccgctgccaa ctttggggca
    11881 atggcgcgct gtgctggcga gagccgaaga ttgcgcgagg acagtgcaag accgtcggct
    11941 tcgcggattg tcggacaggc caggatggtg attggaatgt ccaggtcgcc gaccatgcgc
    12001 ctgaccagct gaagctgctg aaagtccttt tcgccaaaac aggccaagtc agcgccggtc
    12061 tgcaggaaga gcttggaaac gactgtcgcc acgccgtcga aatggcccgg ccgaaagctg
    12121 ccgcacaggc cctcgctgat gccggacacc gaaatgctcg tggcgaagcc tggcggatac
    12181 atctcttctg catccggcag atagagcaaa tgcacgccga gcggcgcaag ccttgcagca
    12241 tcttggtttt ccgtgcgagg ataggcatca agatcggtgg cactgttgaa ttgcttgggg
    12301 ttgacgaaca gcgtcacgac tacccgatcg gccttctgaa gcgcagcacg cacgagactg
    12361 agatgacctt catgcaaggc ccccatggtc ggtacaaggg cgaccttggc gcctgagcga
    12421 cgccatcgcg cggtaacagc gcggagctcg gcagtgcttc gaacgatcgg cacgctcatg
    12481 tgacgtctcc ggccctcgcc tcgtgtgtgt agagatgttc cgccgccgga aagcaccgtc
    12541 tcctgacgtc agcggcataa gccgcaatcg ctgcatcggc ctgttcgcca agttcggcgt
    12601 agcgcttgac gaatttcggc cggaaggagc tgaaaagccc gagcatatcg tcgctcacca
    12661 gaatctggcc gtcgcaggcg agtgaggcgc cgatgccgat ggtggggacg gcgatctccg
    12721 cagtgatgcg ttttgcgagg ggttcgggca ccttctccag caccacggag aatgcgccgg
    12781 cctccgtaac cgcattggca tcgcgcctga tgcgctcggc atcttctccc cgcccctgga
    12841 cgcggtagcc accgagcgta ttgaccgcct gaggcgttaa accgacatgc gccatgacag
    12901 ggatgccgcg ggcgcagagg aagcggatgg tctcggccat tttctcaccg ccttcgagct
    12961 tcacagccgc acaaccggtc tgcgccatca ggcgcgcagc gttgccgaag gcctgcacgg
    13021 ggctctcttc ataggagccg aatggcaggt caacgaccat caatgatcgc accagaccgc
    13081 ggcgcaccgc ctggccgtgc atgatcatca tgtcgagagt gacgcccagc gtcgatgaga
    13141 ggccgtgcaa taccatgcca acgctgtcgc caacgagaac gacgtcgcag tgtggatcaa
    13201 ccaatctggc tatcggcgtg gtgtatgccg tcaggcagac gagtggagcc tggcctttcc
    13261 gcgcgctgat atccggcggt gtgatcgcct ttgtctcacc cgttgcactc aacgatgcat
    13321 ccttccctag cgttaccccc cgcgggtgtc gcgtttggca tatttttgtg cgagtgcgaa
    13381 gtgcaaaaaa gatcgtccag ctgtgcggtg ttgacgttcg tgcagcaacg cttaaattca
    13441 atcgattgat aaccccgaat tcgggaacaa ctcaccttcg cgaacatgaa ccatcaggca
    13501 aaaggaacca gaaaaggcag agccgcggtc aaggccgacg aagcaaaagt ggacctgatc
    13561 gccgttgtcg tcgccgtaac tgacagtgat ccctgtcttc tcaccatcgg gaacgcggat
    13621 acccttccgt ccggccccta tgcgctggag catcgatcgc tgcaatcagg tctgaggggt
    13681 tgggtcgagc aacagaccgg ccacccgctc ggctatatcg agcagctcta caccttcgcc
    13741 gatcgggacc gcataggtgc cgagccccag gaacgcgcca tctcaatcag ctatctcgca
    13801 ctcactcgca aggaacaggc agcgggctcc gctagttgtg ggtggcgcag ttggtacgag
    13861 tatttgccct gggaagatca tcgctccggc acgccggtgg tgctcgatat cttacgacca
    13921 cgcctgagtg agtgggctga gggcgccagc gacgccacca cgcgacgcga acgcctgcag
    13981 cgcgccgcga ttgccttcgg tttcgaccac cgcaattgga atgaggaact caccctacag
    14041 cgttatgagt tgctctatga atctgccctg atcgaagagg ctggccgcgg gcgggacgca
    14101 acgcctgcgg tgacatctgg caaggcaatg gtcgctgacc atcgacgaat cctggcgacg
    14161 ggcattgcgc ggctacgctc caagatcaaa taccggccgg tggttttcga gctcatgagg
    14221 ccgtccttca cgctgcttca gctgcagcgg accgtggagg ccctcgccgg gaggctcatc
    14281 aacaagccga atttccgcag gcttgttgag cagcaagagt tggtcgagga aactggcgag
    14341 acctccctcg agacgggcgg gcgaccggca aagctctatc ggttccggca tgccgtcctc
    14401 gacgacaggg ctggggccgg gacaaaattg ccgctcgcgc gggcttgaca tacttatagt
    14461 caaggtagac atattcccct tattgtcaga tcgaatataa gcggaggcgc tgatgactgg
    14521 ggcgttacct acggctgcgt ccctgtacga gcgcgtccgg cgggtgattc cgccagtcga
    14581 atggccggcg tttaccgacg accttgaagc catccttgcg ctgaagcgcg atcgaaacgc
    14641 ggtcatcctt gcgcacaact accaaacgcc ggagatcttc cattgcgtgg ccgacatcgt
    14701 cggcgacagc ctcgcactgg cccgcaaggc ggccacggtc gaggcgcagg tcatcgtggt
    14761 tgccggcgtg catttcatgg ccgagacggc caagctgctc aatcctaaca agatggtcct
    14821 cattccggac ctccgcgccg gttgctcgct ggccgaatcc atcacggcag aggacgtgcg
    14881 gcagctacgg cagcgctatc cgggggtccc ggttgtcacc tacgtcaaca cttcggcagc
    14941 ggtaaaagcg gagtcggaca tctgctgcac ctcgggcaat gcccgcgcgg tggtggaatc
    15001 tctcggcgtg ccgcgcgtga tcatggtgcc cgatcaatac ctggcgataa acgttgcggc
    15061 ggacacggat gtcgagatca tcgcctggaa gggccactgc gaagtgcatg agcgcttcac
    15121 gtcgaccgac atccgggaat tgcgcgatgc acatcctggg gtcatcgtgc tcgcccatcc
    15181 agaatgcccg cccgagattg tcacacaagc ggaattctcc ggctcgactg cggccatgtt
    15241 ggattatgtc gagcgggaga aaccagcgcg cgtcgtcctg ctgaccgaat gttcgatgag
    15301 cgacaatgtc gcggtcgcgc atcccgaaat cgagttcatc cgcccttgca atctctgccc
    15361 gcacatgaag cgcatcacct tggccaacat ccgcgccgcg ctcgaagaga accggcatga
    15421 ggttcggatc gccgccggga ttgcagagcg cgcgcgccac tcagtcgagc gaatgctttc
    15481 catatgagcc tcgacgttca tgacattggc ggggcaccgg tgatcatcgg ctctggtttg
    15541 gcaggcctga tgaccgcgct ccatctggcg ccggaaccgg ttgtgcttct atctaatgcg
    15601 gggctgggaa ccggagcctg cagcgagctc gcccaaggcg gtcttgctgc aagtgtcggc
    15661 ggcgaagaca gtcccgaact tcatctttgt gacaccctgg cggccggcga cggcctctgc
    15721 gacgaggcaa cggtgcggcg agtggtccga gctgcacctg aagcgatcag gactctagag
    15781 cggtttggag tcgcattcga ccgacgcgct gatggcgcct tgcggctggg gctcgaggcg
    15841 gcgcactcgc agcggcggat cgtgcatgcg gcgggcgatg ccaccggtcg cgaactggtg
    15901 cgcgcgctgg tcgcggcagc acggcgcaca gcctccatca ctgtcctgga aaacgtcgag
    15961 gcccgccggc ttgtcgtgga agacggggcg atcatcgccg tggtcgcggc cgggtgcacg
    16021 ggcgcaatcg ccttgccaac gcgccgcgcg gtgctggcga ccggcggcat cggcgccttg
    16081 ttcagcgaga cgacaaaccc gcctggctca tgtggacagg ggctcgcgct cgccgcttgt
    16141 gccggggcgg agttcgccga cctggaattc gtgcaattcc acccgaccgc cctcgagggc
    16201 ccgcggcggc cgatgccgct ggtgagcgag gcggtgcgtg gcgagggtgc tgtgctcgtc
    16261 gacgagcagg gagagcgttt cctgggtgat accccagggg gcgagcttgc gcctcgcgac
    16321 gtggttgcgc gcgcggtttg gcgccaactc gctctcggac gccgtgtgtt tcttgacgcc
    16381 aggcaatgtc tgggtcccag atttgacaag cgctttccgg cgatcgccga tttgtgccgc
    16441 caggccggca tcgatccggc gaccgacctg atcccggtgc gcccggccgc acattatcac
    16501 atgggcggtg ttgcagtaga cgctgcgggc cgcagctcca tcgagggact gtgggcatgc
    16561 ggcgaggtcg cttgcacggg tctgcacggc gcgaaccggc tcgccagcaa ctcgcttatc
    16621 gaagcagtgg tgacggcgag ctgggttgct gaaagcgtcg ccgacgcatc acacacccgg
    16681 cgaccacgcg tgtgttcggc attcgtgcct caacggccgg acgcctccgg catccgtcca
    16741 atcgtctccg ccgcgctcgg catcgtccgc gacggcgaga cgctacgcga cggggtggct
    16801 accctgttgc cggttgcagc tcacgacagc gcggcgtctg accccgccat ggtcgcgctg
    16861 atgatcgcca ttgcggctct gcggcgcgaa gagagccgcg gctcgcacta tcgttccgat
    16921 ttcgccggac gcgatgcaga tgcgcgccag tcacgactga cactgcgcag cgcaatacag
    16981 accgccgtcg cactcagctg gcgagcgccg atgcggagta ccctgacatg aaattctcac
    17041 cgcttccctc aaccctgatc gaaccgatcg tgcgcggtgc tcttctcgaa gacctgggca
    17101 gatgcggcga tctgaccagc gaggccgtga tcccgcgcga tcgcaccgcc acgttggtgc
    17161 tgaagtcgcg acaaacgggg atcgttgccg ggctcgatct ggccgccttc gccttcatgc
    17221 tcgtcgaacc tgcgatcgac atgcaaatct ggagagttga cggcagcgat gtcgcggggg
    17281 gcgaaatcat cgccatgctg tgcggaccgg cgcggggcct gctcaccgcc gagcgcacgg
    17341 cgctcaattt tctgtgtcat ctaagcggca ttgccactgc cacggcagcg atggtcgaag
    17401 ccgtgcgtgg ccacaaggcg aggatcgtgt gcacgcgaaa gacgacgccc ggcctgcgcg
    17461 cgctggagaa atatgcggta cgcgtcggcg gcggcgccaa tcaccgcttc gggctcgacg
    17521 acgccttcct gatcaaggac aaccacatcg cgatcgccgg cgacattcgc acgacaatag
    17581 agcgggcgcg cgctgccgcg gggcacatgg tgaagatcga ggtcgaggtc gagaccctcg
    17641 agcagctcga tacagcgctc acgctggggg tcgacgcggt gttgctcgac aacatgtcgg
    17701 ttgaggacct tgcccgcgcc gtggcaatgg ttgggggccg cgccgtcacg gaggcttccg
    17761 gccgggtgac accgaaaatg gcaccggcga ttgctgcgac gggtgttgat ctcatctcgg
    17821 tcggatggct gacacacagc gcgcccattc tcgacatcgg cctggacatg ccaactcgcg
    17881 ggaacatcag cactcatttg aactaacggg aaacacaatg gggagcaacg tgctcgggct
    17941 gcgcgcacca aaaggcgcga aagagcacgc ttcatgcggc tcacccttca ttacttccgg
    18001 atcccaatat tgcgcccacc gacgagccaa tcggaagggg ctcccactcg acggactggt
    18061 gagtgcgctc gctgatcggc aatagaggct ttgacgatga caacggaaat gaacgaggag
    18121 tgcgactcgg actttgccac gcagtcgatg gaggcagcac tagcccgatg gagccgcaaa
    18181 gaggccgagg ctatatacgg aatgccgttc aacgatctgc tcttcttggc gcagacggtc
    18241 catcgccaga acttcgatcg caaccgggtg cagctgtcgc ggcttctcag catcaagacc
    18301 ggcggatgcc cggaggattg cggctattgc agccagtctg cgcatcacca aaccggcctg
    18361 aaggcctcga agctgatgga ggtcaaacat gtcgtcgagg aggcgaccaa ggcacgagat
    18421 gctggcgcaa cccgctattg catgggcgct gcctggcgca gtccgaagga gcgcgacatg
    18481 gacgccgtgc tcgccatgat cgaaggcgtg aaggcgctcg gcctggagac ctgcatgact
    18541 ctcggcatgc tcgacctcag ccaggcgcag cgcctgaagg cggccggtct cgactactac
    18601 aaccacaaca tcgacacctc tgcgcgctat tacggcaagg tcgtttcgac caggaccttt
    18661 gccgaccggc tggaaacgct tgggcgcgtg cgcgaggctg ggatcaaggt ctgctgcggc
    18721 ggcattgtcg ggatgggaga ggaaaaggcc gatcgcatgg acatgctggt gacgctggcg
    18781 aacctgcccg agccgcccga aagcgtgccg atcaacatgc tgatccccat cagggggacg
    18841 ccgctcgccg atgccgaacc catcgatccg atcgatttca tccgcaccat tgcgctcgcc
    18901 cggatcatga tgccgaagtc tgatgtaagg ctctccgccg gcaggacggc gatgagcgac
    18961 gagacccagg cgctgtgctt ctttgccggc gccaattcca tttttgtcgg cgacacgctg
    19021 ctgactgcgg acaatcccgg agaggacaag gatactcgtc tatttagacg tctgggcatc
    19081 gaaccgatgc gaggcgaggc gaaatgaacg agccaccgct cgcccgcttt gaagcaacct
    19141 tgcaggggtt ggcacgcaag gaccggctgc gcgcactggc gccgcgggtc gggctcgact
    19201 tctcgtccaa cgattatctc gggcttgctg ccttcaagag acttggcgat gcagtcgcgg
    19261 cggcaatcga gcggggcacc cctgtgggcg ctaccggatc gcggcttctg cgcggcaacg
    19321 cgccggagca tgaggcgctg gagtcagatg ctgccgcgtt cttcggggcc gaacgggcgc
    19381 tgttcttcgg cagcggctac atggccaact tcgccctcct gagcaccctg gtgaagaagg
    19441 gcgacctgtt gatcctcgat gaactcgccc atgccagcat gcatgaaggg gcccgggcag
    19501 gacgcgccga gttcaggctg gtggcacaca atgacattga tgcttttgag gacgcgatca
    19561 ggcgctggcg cgccgaaggc ggcattggcc gcatctggat cggcgttgaa agcctctaca
    19621 gcatggatgg cgactgcgcg ccgatggaga gcctggttga gcttgccgat cggcacgagg
    19681 ccttcatact ggtcgacgag gcacatgcca caggtgtctg gggaccgggg ggccgcgggc
    19741 tggccgccgc gttcgagggc cgcgacaaca tcgtggctct ccatacatgc ggcaaggcac
    19801 tcggcgcatc gggcgcgctc gtcaccgggc cgcgagtgct gtgcgactat attgtcaatc
    19861 gctgccgtcc gtttatctac gccaccgcac catcgccgct gatggcagtg gctgcgcgcg
    19921 aagcgctcgc aatgctggtc gacgagccga tgcgccgcgt tgatttgcac gagcacgttg
    19981 ccttcgcaag ccggcaactg gccgagcatt gcggagccaa gcccagcggt tcgcagatcc
    20041 acccatttgt cattggggac gtggcgcgca ccatggctgt cgcggcggct ctgcaggctc
    20101 gcggcttcga cttacgcggc attcgtccgc cggcggtgcc ggagggtacc tcgcggctgc
    20161 gcatttcgct gacgctcaac gtgggcaagg ctgacattcg cgtcatggtc gagacgcttg
    20221 ccgaagtatt ggccaccacg gcatgagcaa gcgcatcgtc gtcacgggaa ccgatacggg
    20281 aattggcaaa accgttttcg ccgcggggct cgcaggtctg ctcgacggct tctactggaa
    20341 gccggtccaa tcgggtctcg aaggtgagac cgacagtgag gtggtcgaac ggctcgctgg
    20401 cctgccatcg gggcgggtgc tgccggaggc ccaccgcttg aggagcccct tgtcgccgca
    20461 ccgttcagcc gaaatcgacg gtgtctcgat cgagcctgcc gatctttcat ttccggtcct
    20521 gcccacaccg ctcgtcatcg aaggcgctgg cggactgatg gtgccgatca atcgacagac
    20581 aagattcatt gacatcttcg ctgaatggcg gctgccggtg atcctgtgcg cccgca
//
