LOCUS       NZ_BBVA01000010        22146 bp    DNA     linear   CON 10-SEP-2024
DEFINITION  Micromonospora sp. NBRC 110037, whole genome shotgun sequence.
ACCESSION   NZ_BBVA01000010
VERSION     NZ_BBVA01000010.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Micromonospora sp. NBRC 110037
  ORGANISM  Micromonospora sp. NBRC 110037
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Igarashi,Y., Komaki,H., Ichikawa,N., Hosoyama,A. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Micromonospora sp. NBRC 110037
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 262484)
  AUTHORS   Hosoyama,A., Ichikawa,N., Kimura,A., Ohshita,R. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 106x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001652995.1-RS_2024_09_10
            Annotation Date                   :: 09/10/2024 02:06:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,195
            CDSs (total)                      :: 6,136
            Genes (coding)                    :: 6,073
            CDSs (with protein)               :: 6,073
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 15 of 63
            Pseudo Genes (incomplete)         :: 53 of 63
            Pseudo Genes (internal stop)      :: 4 of 63
            Pseudo Genes (multiple problems)  :: 9 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 35704
            Orig. end                         :: 57850
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBVA01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22146
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22146
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22146
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12146]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12146
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(285..797)
                     /locus_tag="A4R25_RS25475"
     CDS             complement(285..797)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018811918.1"
                     /locus_tag="A4R25_RS25475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SRPBCC family protein"
                     /protein_id="WP_064448343.1"
                     /transl_table=11
                     /translation="MGQEMADPDEVRQESDRFSLRSNLFAPASAERAYAVFTGSLADWW
                     VREYTWSGPQALAALGIEPRAGGMLYEIGPYGFRNDWGRVLTWDPPRRLVFTWQIGPDR
                     VPVPDPAGASEVEVLFHPEGPELTRVEVEHRYFDRHGAAAEGYREALTAGWHELLCRYL
                     ATVARTA"
     misc_feature    796..811
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.65"
                     /tool="antismash"
     gene            1095..1532
                     /locus_tag="A4R25_RS25480"
     CDS             1095..1532
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283444.1"
                     /locus_tag="A4R25_RS25480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ArsI/CadI family heavy metal resistance
                     metalloenzyme"
                     /protein_id="WP_043327526.1"
                     /transl_table=11
                     /translation="MSRVQLALRVSDLEGSVAFYSKLFGVEPAKRRPGYANFAVENPPL
                     KLVLLEGEPGLPTVMDHLGVEVATTGEVNAATSRLTESGLITLEENDTECCYALQDKVW
                     VRGPGDEPWEVYTVKADSPQLEKVTESACCASDTAEQPAGV"
     gene            complement(1583..2167)
                     /locus_tag="A4R25_RS25485"
     CDS             complement(1583..2167)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018832247.1"
                     /locus_tag="A4R25_RS25485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetyltransferase"
                     /protein_id="WP_064448344.1"
                     /transl_table=11
                     /translation="MLHAVTGPEITVATPEDRAQVVTSLVAAFTKDPVLRHLFPDEATY
                     ARYAAVFFGHLFDKRVHKETIWTIGHGASVAIWEPPASGSAPPDDDLAARLPADVLHRV
                     RAYDEAVHAALPSAPFWYLGVLGTHPDHAGRRWGHAVMRVGLDRAAADGLPAILETSNP
                     DNVEVYRRAGWEVVHAFAEPLPTWVMRNRRT"
     gene            complement(2219..3205)
                     /locus_tag="A4R25_RS25490"
     CDS             complement(2219..3205)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013473453.1"
                     /locus_tag="A4R25_RS25490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_231915633.1"
                     /transl_table=11
                     /translation="MSTRRSHVRTLRTALTSVLVLAVILVGGCGRISGLLDSVSLFHPV
                     WAADGWVYYLREVTSTSGSGVAEVWRQRPDGSGEEAVLTRAPAVPACEAGLFSFLFADP
                     DGDLGVALECGWDGTELLTYSPADKTFEPLASTRFLAGAALVNGDGRGYVQARRKCGPG
                     GIQLLADGKASEFPSPVTVDGTTFNLSGSDTGCESMVLVRSPATMGERLFFITAPDTLG
                     RLPLPVEVYPSDFTWHLTEWDVGSATARFLAELPGLADLAVSPDGRSVIAAVASDHVGG
                     VWSVDVDTGKKTRIADGERAYHPSFSPDGKRFVYVEAFRRLRFAEAR"
     gene            complement(3353..4588)
                     /locus_tag="A4R25_RS31590"
     CDS             complement(3353..4588)
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015411.5"
                     /locus_tag="A4R25_RS31590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_197494968.1"
                     /transl_table=11
                     /translation="MKIIAVLGTGHMGTPIARRLLAGGNRVRVWNRSPERSEPLAAVGA
                     TVAASPSAAVDGVEVVVVMLADAGAVETVLFGPDGAATALRPGTVVVQMSTIGPDEVRA
                     VAGRLPAGVYLLDAPVGGSVNAARAGTLVIFAGGPADAVERAAPVLGQLGTVRHCGPIG
                     AGAAVKLVANTGLVTAVAALHDALAVAAALGVDRQTALDVLDRGALGGAVGRATASGAS
                     FAVTMAAKDARLALRRPVPAPVLEAALDLMRAAPDQDADLSSLVSPDFCEGTPMRLTLD
                     NPESVAAPFGDRFAHVARIDVGGGALLMLAGQVAVDDDGEVVAPGDAGAQAERIFEIVG
                     GVLAAHGASFDDVLHVRTFMTDLADLSAYAAVRRRLFPGTPPPASTTVEVSRLFLPGAV
                     LEVEVTAVVRSR"
     gene            4669..5565
                     /locus_tag="A4R25_RS25500"
     CDS             4669..5565
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020510278.1"
                     /locus_tag="A4R25_RS25500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_064448345.1"
                     /transl_table=11
                     /translation="METQLLEVFRTVARHGSVTTAARALSFTQSAVSRQIAALEADIGA
                     RLFDRLPRGVALTEEGRELLPHAEAVLDRLAAARRDLDDLRGLGRGRLRVGAFPTAVAA
                     LVPRAMASFRSAYPEVSLSLVEGVTPRLLERLLAEEADVAVVSTSPTGELDRERFDLRH
                     LLDERLLVAVARDHRLARRRSVRLADLAPEAFVVGSATAENSLLRASLPSGFSPRIDIV
                     AAEWTGKLGCVAAGLGVALVPALAVRGTPPDIALLRLHPDDESVRQIFAATVRGRTPPP
                     AVTHFLEHLRAEAAHLG"
     misc_feature    4709..4724
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     tRNA            complement(5629..5702)
                     /anticodon=(pos:complement(41370..41372),aa:Phe,seq:gaa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="A4R25_RS25505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Phe"
     gene            complement(5629..5702)
                     /locus_tag="A4R25_RS25505"
     tRNA            complement(5779..5852)
                     /anticodon=(pos:complement(41520..41522),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="A4R25_RS25510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Asp"
     gene            complement(5779..5852)
                     /locus_tag="A4R25_RS25510"
     tRNA            complement(5886..5958)
                     /anticodon=(pos:complement(41626..41628),aa:Glu,seq:ttc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="A4R25_RS25515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Glu"
     gene            complement(5886..5958)
                     /locus_tag="A4R25_RS25515"
     gene            complement(6102..6887)
                     /locus_tag="A4R25_RS25520"
     CDS             complement(6102..6887)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013730889.1"
                     /locus_tag="A4R25_RS25520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_043327523.1"
                     /transl_table=11
                     /translation="MRPRALPALALGLVLLVTACGEAGKSPDQAAASPSVSASPSPVTK
                     PSPTPTATPRKPKLRPVPKKLPAGLHRASGSSGVALTFDDGPDPRYTPQILAQLRAARV
                     TATFCVVGQQAKRYPELVARIVREGHQLCNHSWHHDVNLGRRSATEIRADLERTNDAIR
                     AAAPKAPITWFRQPGGRWTAEEIVVARQMGLRPLHWSVDPQDWDHPPAKTIIKRVKGAT
                     RNGSIVLMHDAGGDRAQTMAACRHLIPDLKRRYGIARLP"
     gene            complement(6963..7910)
                     /locus_tag="A4R25_RS25525"
     CDS             complement(6963..7910)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018255064.1"
                     /locus_tag="A4R25_RS25525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_064448346.1"
                     /transl_table=11
                     /translation="MADEALSAGAVARRLGVAVTTLRTWHQRYGLGPSEHVPGHHRRYT
                     PADLARLEIMRRLTTEGVAPAEAARWARQAPAVPPPDRLALKARTSAVRDGGGTTIPVG
                     RAGPAARGLARAAMRLDSVTIARTIAEALAADGVVATWEGLLRPVLTGIGERHAATAGL
                     IEVEHLMSRCVSVAFATVIRAHPNGGPPRILLSCADEEQHSLPLEALAAALAEAGVSCR
                     MLGARVPLPALVEAVNRTGPAAVVLWSHTRATADPCQLTALLTVPRRPLLVLAAGPGWR
                     ADSLPAGVVRPVDLAEALSLALAVRDSLDQSTKG"
     gene            complement(7900..8493)
                     /gene="idi"
                     /locus_tag="A4R25_RS25530"
     CDS             complement(7900..8493)
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283449.1"
                     /locus_tag="A4R25_RS25530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_043327521.1"
                     /transl_table=11
                     /translation="MSEREEHLVELVGDDGQVLGETTVATAHQPPGRLHRAFSVLLVDP
                     QGRVLLQQRAAVKTRFPLRWANSCCGHPLPGQSLTEAANRRLGEELGVGPVELTEVGVY
                     IYYAEDPATGRVEFEYDHVLRADVPADLVTRPDPDEVAELRWADPGAVVADLDADPRAY
                     APWLGGVVNRLLHPAGPARPGVAASEAPERSGGR"
     gene            complement(8490..9971)
                     /gene="crtI"
                     /locus_tag="A4R25_RS25535"
     CDS             complement(8490..9971)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018222034.1"
                     /locus_tag="A4R25_RS25535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_197494969.1"
                     /sec_met_domain="DAO (E-value: 4.7e-19, bitscore: 63.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVKGRTDRVVVVGAGLGGLACALHLAGSGRQVTVLEREPVPGG
                     RAGRLSVDGYEFDTGPTVLTMPDLIAEALGAVGEELTDWLDLSPLDPAYRAYYPDGSTL
                     DVITDTTRMAAEIARVCGPREADGYLRFVDYARNLWQWERADFIERNLDAPTDLLTGNL
                     LKLFANGAFRRLQTKINQFFRDPRTQRIFSFQAMYAGLSPHDALAIYAVIAYLDSVAGV
                     CFPRGGIHAVSRGMAGAAEKHGVQFRYGTTVTRVETANGRATGVITSDGDFVPADTVVL
                     NPDLPVAYEDLLPPSRQRKLTYSPSCVVLHIGSTQGYGKIAHHNIHFGRSWKGTFDEVI
                     RRGELMTDPSLLVTNPSRTDPSVAPAGKHTYYVLAPVPNLERAPLDWTGDLTQRYADQL
                     VGTLEERGYVGFGDGIEVMRAVTPADWAAQGMAAGTPFAAAHRLFQTGPFRPSNLHRKL
                     DNVVFVGSGTQPGVGVPMVLISGKLAAARITGATA"
     gene            complement(10001..11155)
                     /locus_tag="A4R25_RS25540"
     CDS             complement(10001..11155)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019901498.1"
                     /locus_tag="A4R25_RS25540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_064448348.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.3e-49, bitscore:
                     161.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANDAVAGNALRVAPAQAGATDDPVRGVLAAFTKDLIKGVDKTLV
                     AFLAAEVDSLTEIDAAMGAFAATARDCVLAGGKRVRPTFAYWGWRGAVGGEEPMCSVLP
                     ALSALELLHTFALVHDDVMDASDTRRGLPTAHRAAAARHRAAGHAGDPDRYGEAVAVLI
                     GDLCMVWADRLLGHAAVPAERLLDVRRCYDQMRVETVAGQFLDVLGENDAGNWTVDRAL
                     RVARYKTASYTVQRPLLFGACLAGTDPDDPLIAAYTRYGLAVGEAFQLRDDLLGVYGDP
                     ETTGKPAGDDLRTGKPTALLMLARQLADPAQRRALDRAGSVTTARDVDRLADVVRDTGA
                     TARVERMIADRVTEALAALGTAPIDETARTALTGLATAATARRA"
     misc_feature    complement(11156..11174)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.7"
                     /tool="antismash"
     gene            11220..12146
                     /locus_tag="A4R25_RS25545"
     CDS             11220..12146
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785446.1"
                     /locus_tag="A4R25_RS25545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_064448349.1"
                     /sec_met_domain="phytoene_synt (E-value: 9.6e-115,
                     bitscore: 376.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.3e-65,
                     bitscore: 213.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVDLAAAYDRCRELHRRHGRTYYLATRLLPAWKRRHVHALYGFT
                     RYADEIVDRTEDLPPAERAARLREWSDRFVAGLHGASVDDPLLPAVLHTIAVFDLDCDD
                     FASFLRSMAMDLTVMSYPTYDDLLDYMEGSAAVIGTMMLPILGSSDPAAAREPARQLGF
                     AFQLTNFIRDVAEDLDRGRTYLPDEDLAKFDVTRADLVAAKAAGRTTPRIRELIEYEVT
                     RAQAHYLAAAPGIPLLNPASQACMRTAYALYGGILDEVAAQDYDVFVRRALVPQRRRMA
                     VAARALLTPPGTPVQVPGPALEPALAG"
     gene            12143..13465
                     /locus_tag="A4R25_RS25550"
     CDS             12143..13465
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283453.1"
                     /locus_tag="A4R25_RS25550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_064448350.1"
                     /transl_table=11
                     /translation="MTGRTAVVLFTRDLRVHDHPALAAACSAFERVVPLYVLDPELQQL
                     SPNRTRFLHQSLADLREALRKRGGDLVIRRGDPVAETVKLARKVGAEGVGLSADVSHYA
                     RRRERRLRAECDRHRMFLRLFPGLTIVEPGALRPSGGDHYRVFSPYFRAWQGVRLRDEL
                     AAPKRVRLPDGVDPGRPPDPPKGDSPAAAVGGENAARRRLTAWLPTLDRYDDIHDDMAG
                     DETSRLSPYLRFGCVSPLAVATRAGDRDGPFVRQLCWRDFYHQVVAGFPDLSTAAYRRG
                     AREDWRYDEHALDAWTEGRTGMPIVDAGMRQMRAEGWMHNRARLITTGYLTKHLGLDWR
                     PGLEVFFRWLLDGDRVNNSGNWQWVAGTGNDTRPYRGFNPVRQAERYDPDGAYVRRWVP
                     ELESVAGKAVHQPWRLPDAVRRTLDYPPPLEVPGADPVWLR"
     gene            complement(13826..14926)
                     /locus_tag="A4R25_RS25555"
     CDS             complement(13826..14926)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013473461.1"
                     /locus_tag="A4R25_RS25555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase"
                     /protein_id="WP_064448351.1"
                     /transl_table=11
                     /translation="MHTRFTPVRDCFHDLFVTGRETGASLAVWHDGVPVIELMGGTAAA
                     VPPSAVAPMAGADRAWRPDTLVDVYSTGKPVVALCLLLLVDRGRVDLDTPVSAYWPEFR
                     TPATVRQVLAHTAGLPAFPVPRPAAAIADWGLLCADLAAAEPEWDPGAVAGEHAWTYGH
                     LVGELVRRVDGRPVGRFLAEEIAGPWRLDLAFGLGEADRRRCADLSYADPAWPDAMRGE
                     PGSLRARALDNPPGGRDVAMVNSDLWRAAEIPAVNLHATAAGLARLYAGLLASGTLDGV
                     RLFSPELVAEATRVQYSGPDLLLDRPVDWTLGMQWEPDGSWGMGGIGGSSAWADPERGY
                     TFAYATARLADHDRVEELVEALHSCL"
     gene            15019..16503
                     /locus_tag="A4R25_RS25560"
     CDS             15019..16503
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283455.1"
                     /locus_tag="A4R25_RS25560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_064448352.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-44, bitscore:
                     146.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEPEQVDVVVVGLGVGGEEVAGRLAEAGLTVVGIERDLVGGECP
                     YWGCVPSKMMIRAANALAEAHRVNELAGSAQVRPDWAPVAKRIRAEATDTWDDKVAVDR
                     FTGKGGRFVRGSGRLDGPNRVRVGDQVFPARYGVVLGTGTRPSVPPIDGLADTPYWTNH
                     QAIEVEELPASLLMLGGGAIGLELAQVFARFGVRVTVIEAADRVLAVEEPEASALAADA
                     LRADGVEIHTGVKAGWVGHDGGAFTVYADGAEFTGEKLLVVTGRKAHLEELGLDTVGVD
                     AGQRYLPVNDRMHVTDGIWAVGDLTGEGAFTHIAMYQAGIVVADVLDHMRRTKGGPDAS
                     GTASVVGGAAGVVSSVGGAMSAGGSSVAPGSVPVADYRALPRVTFTDPEVGAVGLTEQQ
                     ARERGVNVQVGYADLTSSARGWIHKTGNAGFIKLVADADQGVLIGATSAGPAGGEVLSA
                     LVVAVHAAVPISQLRHMIYAYPTFHRAIEDALRALK"
     gene            complement(16508..17272)
                     /locus_tag="A4R25_RS25565"
     CDS             complement(16508..17272)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (5-202). E-value: 3.2e-42. Score:
                     136.4. Matches aSDomain:
                     nrpspksdomains_A4R25_RS25565_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785442.1"
                     /locus_tag="A4R25_RS25565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_064448353.1"
                     /transl_table=11
                     /translation="MGVRVEHAGAVTTVILDRPEARNAVDGPTARALADAFRAFDADPD
                     AAVAVLWGAGGTFCSGADLKAVGTPRGNRVEPEGDGPMGPTRMRLSKPVIAAISGYAVA
                     GGLELALWCDLRIAESDATLGVFCRRWGVPLIDGGTVRLPRLIGESRAMDLILTGRPVG
                     ADEAYAMGLVNRLVAPGAARAAAEELAAAIAGHPQTCLRNDRAAVLDGAGRPEPEAMAT
                     ELAYGMESLAVDGVRGAGRFAAGAGRHGAPAG"
     aSDomain        complement(16667..17257)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS25565_ECH.1"
                     /evalue="3.20E-42"
                     /label="A4R25_RS25565_ECH.1"
                     /locus_tag="A4R25_RS25565"
                     /protein_end="202"
                     /protein_start="5"
                     /score="136.4"
                     /tool="antismash"
                     /translation="EHAGAVTTVILDRPEARNAVDGPTARALADAFRAFDADPDAAVAV
                     LWGAGGTFCSGADLKAVGTPRGNRVEPEGDGPMGPTRMRLSKPVIAAISGYAVAGGLEL
                     ALWCDLRIAESDATLGVFCRRWGVPLIDGGTVRLPRLIGESRAMDLILTGRPVGADEAY
                     AMGLVNRLVAPGAARAAAEELAAAIAGHPQTCLR"
     gene            complement(17313..17738)
                     /locus_tag="A4R25_RS25570"
     CDS             complement(17313..17738)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013970.5"
                     /locus_tag="A4R25_RS25570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PIN domain nuclease"
                     /protein_id="WP_064448354.1"
                     /transl_table=11
                     /translation="MKLADYLIDTSALVRLLRDPDVLARWEQQVTAGLLAVCPLVELEF
                     LYTARSVADRTRLTEQLRAAFGWVVMPDRIYERAAEVQGELTVRGTHRSAGAVDLLIAA
                     TAEYHGLSLLHYDRDFDQVGAVTGQPMRWLTRPGSIK"
     gene            complement(17735..17944)
                     /locus_tag="A4R25_RS25575"
     CDS             complement(17735..17944)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015619667.1"
                     /locus_tag="A4R25_RS25575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_064448355.1"
                     /transl_table=11
                     /translation="MTKILVDVDDEALADAAEAFGTKTKKDTVNVALREGAARLRRARA
                     LADLAERGQAGDFDELLDKGAYRS"
     gene            18055..18906
                     /locus_tag="A4R25_RS25580"
     CDS             18055..18906
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785440.1"
                     /locus_tag="A4R25_RS25580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_064448356.1"
                     /transl_table=11
                     /translation="MRELLTKIEQATGLDRVGDRLQRAVQGTLRSQRVRDALHGVWLGH
                     PLHPAMVQVPVGAWISAAVVDLLPGQRRAATALVGLGTVSALPAAVAGLNDWATLSRDQ
                     RRIGLVHAAANTVGLALYAGSLAARLNGRHGLGRALSYLGLSAASGGAYLGGHLAYKQG
                     AQASQSVSELHLISDGWHRVGDLSSLPRHELVTKKIDDVSVILYRDGDDVTVMLERCPH
                     QSGPLGEGTVEQIDGHACVVCPWHGSAFRLNGGEVVHGPAANDQIVLPTRVVSGRVEAR
                     LP"
     gene            complement(18908..19918)
                     /locus_tag="A4R25_RS25585"
     CDS             complement(18908..19918)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013473464.1"
                     /locus_tag="A4R25_RS25585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="WP_064448357.1"
                     /transl_table=11
                     /translation="MGAPRRSPVRRAGQVLTGLGALVVLVGVLAGGPVALLAFAGNPLP
                     DHLPTFAEIGTTLTSRDDGQLFLRALAVVGWFGWATFAFSVVVELLAAAVRRPAPKLPG
                     MHRQQKAAAALVGSVALILAASPAAASAAALTAPQPAVAASAVTAPSRVAPPAPVASKA
                     DDPAVYRVAKGDYLGEVADRYLDDFDRYKELARLNRLADPDRIRPGQLITLPDGATDSG
                     ARRHATGRLVVTKPAQTAPVKPGGGGASSSAPQAKPKPTPRDATPTVEAPVGQPPAMSA
                     GASRPTAEEGINRPLAISAVLAVASIVGAQIGALLGLRKRPVPARAGSSGRHRRD"
     gene            complement(19934..20365)
                     /locus_tag="A4R25_RS25590"
     CDS             complement(19934..20365)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785438.1"
                     /locus_tag="A4R25_RS25590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_064448358.1"
                     /transl_table=11
                     /translation="MTGRRAAESGRVSLFLAVAMTGVLAIISLAYDGAGQLRTLQRADN
                     LAAEAARAGGQMIDRARAIEGGPKQIDQVAARAAVAAYLDAAGGVQDHEVDFPVVGAET
                     QIRVSVQITYSRDLLSLFGVQNTATVTGEATARALTGPP"
     gene            complement(20362..20835)
                     /locus_tag="A4R25_RS25595"
     CDS             complement(20362..20835)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283460.1"
                     /locus_tag="A4R25_RS25595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TadE/TadG family type IV pilus assembly protein"
                     /protein_id="WP_043327510.1"
                     /transl_table=11
                     /translation="MSAGPRRDRGSVSIEVAVLAPAFIGLMVLAGVAGRTAIADEAVES
                     AAHDAARAASLARNADDGAEAAEEAARNQLGWAGLNCSGPPQLDLAGSVAGTTTSFAAA
                     YASAAGVPATVTVTVTCTVSFDDLSAPGLPGVPGGKTVSARFTSPLDTYRSRG"
     gene            complement(20832..21302)
                     /locus_tag="A4R25_RS25600"
     CDS             complement(20832..21302)
                     /GO_process="GO:0009297 - pilus assembly [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013473467.1"
                     /locus_tag="A4R25_RS25600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TadE family protein"
                     /protein_id="WP_064448467.1"
                     /transl_table=11
                     /translation="MPRPARTVRSRPAPAGPPGPGRIAAALRARLAEGERGANPVELAV
                     VMPVILVMLFGSIQVAVWFVARSTALNAAQTGVNAQRTIDAGPDAGRERAISFLQQSGD
                     WLVDWEQTGPTCVESATAVTCTVQGRSLSVIPGVSFAVTQTAHGPAERWTTG"
     gene            complement(21302..21511)
                     /locus_tag="A4R25_RS25605"
     CDS             complement(21302..21511)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283462.1"
                     /locus_tag="A4R25_RS25605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_013283462.1"
                     /transl_table=11
                     /translation="MHLYAYLYVAVSTRLAELRRDSERGDSPVPTAVIIFGLVAVAMAV
                     TGLALAKANNWMNAIPNNTAPQAP"
     misc_feature    21762..21776
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 gcgtacgtcg tcgcgcagcg gctgcgcgca gccgaggaga acgcggtggc cgaggcgggc
       61 ggcccctcga cggccctggt actcgccgac cgttccgacc gcgtccagcg ccgggtcgcc
      121 gaggcgtacc ccaggttgcg caccgcgccg cgacggcgcc tcgcgggcgg tggtttcgcg
      181 ccgggcgcgg acgccggccg ccgcgccgac ctcggcggca ccggcgtgcc cggcgccgcg
      241 gcgacgccgg gcatcaccgg ctgaccgggc ccatcgggta cgggtcaggc ggtgcgggcg
      301 accgtcgcca ggtagcggca gagcaactcg tgccagccgg ccgtgagcgc ctcgcggtag
      361 ccctcggccg cggcgccgtg ccggtcgaag tagcggtgct cgacctcgac ccgggtcagt
      421 tccgggccct cggggtggaa caggacctcc acctcgctgg cgccggccgg gtccggcacc
      481 ggcacccggt ccgggccgat ctgccaggtg aagaccagac gcctaggcgg atcccaggtc
      541 agcacgcggc cccagtcgtt gcggaagccg tacgggccga tctcgtagag catgccgccg
      601 gcccggggtt cgatgccgag cgcggcgagc gcctgcgggc cggaccaggt gtactcgcgt
      661 acccaccagt cggcgagcga tccggtgaac acggcgtacg cccgctcggc cgacgccggg
      721 gcgaacaggt tgctgcggag ggagaagcgg tcggattcct gccggacctc atccggatcg
      781 gccatctcct gtcccatagg tccggaccat accggctcat gtctcggtgc gcagcttccg
      841 ttgcgcccgc ttccggacac cgggaacgcc gctccacgac agcgctgtgt ggtgggacag
      901 gcgcgccgag ttggcggaac gcctcggggc gtacccggta ccaggcctag gtgccgcgcc
      961 gctcggagcc ggacgcagat ctccgacgcc gaggcgccgg cagcgcttgt ttcgacattt
     1021 ctctaggttg acagacttca aagcagaggg cagggtggag tctgcttcga taaacatcta
     1081 gacagggagt tcacatgtcc cgcgtccagc tcgccctgcg cgtgtccgac ctcgaaggct
     1141 ccgtcgcctt ctacagcaag ctgttcggcg tcgagccggc caagcgccgc cccggctacg
     1201 ccaacttcgc ggtggagaac ccgccgctga agctcgtact cctcgaaggt gagcccggcc
     1261 tgccgacggt gatggaccac ctcggggtcg aggtggccac caccggcgag gtgaacgccg
     1321 cgaccagccg gctcaccgag tccggcctga tcacgctgga ggagaacgac accgagtgct
     1381 gctacgcgct ccaggacaag gtctgggtgc gcggccccgg cgacgagccg tgggaggtct
     1441 acacggtcaa ggccgactcg ccgcagctgg agaaggtgac cgagagcgcc tgctgcgcct
     1501 cggacaccgc ggagcagccc gccggcgtct gaacggcgga tccccaccgg cgtctccgcc
     1561 ggtggggatc tctgtcgtac ggtcaggtac ggcgattccg catgacccag gtgggcagcg
     1621 gctccgcgaa ggcgtgcacc acctcccagc cggcgcgccg gtacacctcg acgttgtccg
     1681 ggttgctggt ctccagaatc gccggcaggc cgtccgcggc ggcccggtcc agccccaccc
     1741 gcatcacggc gtggccccac ctgcggccgg cgtggtccgg gtgcgtaccc agcaccccca
     1801 ggtaccagaa cggcgccgac ggcagcgcgg cgtgcaccgc ctcgtcgtag gcgcggacgc
     1861 ggtgcaacac gtcggcggga agccgggcgg cgagatcgtc gtccggcggg gcgctcccgg
     1921 atgccggcgg ctcccagatc gccaccgacg cgccgtgccc gatcgtccag atcgtctcct
     1981 tgtgcacccg cttgtcgaac aggtgcccga agaagacggc cgcataacgc gcataggtcg
     2041 cctcgtcggg gaacaggtgc cgcaggaccg gatccttggt gaacgccgcg accagcgacg
     2101 tgacgacctg ggcgcggtct tccggcgtcg caacggtgat ctcaggccct gtcacagcgt
     2161 gcaacatatc gtgcggccga ggcgcggggc gtccctcgcg gcgtgagccg gccggcgact
     2221 accgtgcctc ggcgaacctc agccgcctga aggcctcgac gtagacgaac cgcttgccgt
     2281 ccggagagaa gctcgggtgg tacgcgcgct caccgtcggc gatccgcgtc ttcttcccgg
     2341 tgtcgacgtc gaccgaccac acgccgccca cgtgatccga cgcgacggcg gcgatcaccg
     2401 acctgccgtc cggcgacacc gccaggtcgg cgagcccggg aagctccgcg aggaacctgg
     2461 ccgtggccga tccgacgtcc cactcggtca ggtgccaggt gaagtcagac ggatacacct
     2521 cgacaggcag cggcaacctg ccgagggtgt cgggtgcggt gatgaagaac agccgctcac
     2581 ccatggttgc cggcgaccgc accagcacca tggactcgca acccgtatca ctgccactga
     2641 ggttgaaggt tgtcccgtcg accgtcaccg gagaggggaa ctcagacgcc ttcccgtcag
     2701 cgagcagctg gattcccccc ggcccgcact tccggcgcgc ctgcacatat cccctgccgt
     2761 caccgttcac gagtgcggca ccggcgagga agcgcgtcga cgccagaggc tcgaacgtct
     2821 tgtcggccgg cgagtaggtg agcagctccg ttccgtccca gccgcattcg agggccaccc
     2881 cgaggtcgcc gtcggggtcg gcgaacaaga agctgaacaa gcccgcttcg caggcgggca
     2941 ccgccggggc gcgcgtgaga acggcttcct cgccgctccc gtcgggccgc tgccgccaca
     3001 cctcggctac tcccgagccc gaggtcgagg tcacctcccg caggtagtag acccagccgt
     3061 cggcggccca caccggatgg aacagggaga cggaatccag gagccccgag atccggccgc
     3121 acccgcccac caggatcacg gccagtacga ggaccgacgt cagagccgta cgcagcgtcc
     3181 gcacatgcga ccttctggtg ctcacctgcc tcattccgtc cgtcactcag cgggctcacc
     3241 gtaggcgccg ccgccgttgc cggggaccgt acacccgtta ggtactcagg gtggcgacct
     3301 gtgccggccg tggatacggc caaccgaccg ggaagcgcaa tcgtcgcgac acctagcggg
     3361 accggaccac ggccgtgacc tcgacctcga gcacagcgcc cggcaggaag agcctgctga
     3421 cctcgacagt cgtgctcgcc ggcggcggtg tgccagggaa gagccgtcgc cggacggccg
     3481 cgtacgccga caggtcagcc aggtccgtca tgaacgtgcg gacgtgcagc acgtcgtcga
     3541 agctcgcgcc gtgcgccgcg agcacgccgc ccacgatctc gaagatccgt tcggcctggg
     3601 cgccggcgtc tccgggggcc accacctcgc cgtcgtcgtc aacggcgacc tgtccggcga
     3661 gcatcagcag cgcgccgccg ccgacatcga tccgggcgac gtgcgcgaag cggtcgccga
     3721 acggggccgc gacggattcg gggttgtcca gggtgaggcg catcggcgtc ccttcgcaga
     3781 agtcggggga gacgagggag gagagatcgg cgtcctggtc cggcgcggcc cgcatcaggt
     3841 cgagggcggc ctccagcacg ggggccggca ccgggcggcg cagcgccagc cgggcatcct
     3901 tcgccgccat cgtgactgcg aacgaggcgc ccgaggctgt ggcccgtccg accgcgccgc
     3961 cgagggcccc acggtcgagc acgtcgaggg cggtctgcct gtcgacaccg agcgctgcgg
     4021 cgacagccag cgcgtcgtgc agcgcggcga cagccgtcac caggcccgtg ttcgcgacga
     4081 gtttgacggc ggcacctgcg ccgatcggac cgcagtgacg gaccgtcccg agctgcccca
     4141 gcaccggagc cgccctctcc acggcatcgg cagggccgcc cgcgaagatc accagcgtgc
     4201 cggcccgggc ggcgttgacg ctgccgccga cgggggcgtc gaggaggtag acgcccgccg
     4261 gaagccggcc ggccaccgct cggacttcgt ccggcccgat cgtcgacatc tgcaccacga
     4321 ccgtcccggg tcggagcgcg gtggcggcgc cgtccggccc gaacagcacc gtctcgaccg
     4381 cgccggcgtc ggcgagcatg acgacgacga cctcgactcc gtcgaccgcg gcggacgggc
     4441 tcgcggccac cgtcgcgccg accgccgcga gcggctccga acgctccggg ctgcggttcc
     4501 acactctgac ccggttgccg ccggccagga ggcggcgcgc gatcggcgta cccatgtgcc
     4561 cggtcccgag gaccgcgatg atcttcacgc ggtaacgcta ggccggtgaa agcaatgcga
     4621 caaacgaatg tcttgcatgc ctgccatgcg tgattaccat gcctgcccat ggagactcag
     4681 ctgctggagg tgttccgcac cgtcgcgcgg cacggctcgg tcaccaccgc cgcgcgcgcc
     4741 ctcagcttca cccagtcggc tgtctcccgg cagatagccg cgctcgaggc cgacatcggc
     4801 gcccggctct tcgaccggct gccccgcggc gtcgccctca ccgaggaggg acgagagctg
     4861 ctcccgcacg ccgaggcggt cctcgaccgg ctcgccgcgg cccggcgtga cctcgacgac
     4921 ctgcgtgggc tcggccgagg gcggctgcgt gtgggcgcct tcccgaccgc tgtcgcggcc
     4981 ctcgtacccc gggcgatggc gtcgttccgc tcggcctacc cggaggtctc gctttcgctg
     5041 gtcgagggcg tgacgccgcg gctgctggag cgcctgctcg ccgaggaggc ggatgtggca
     5101 gtggtcagca cctcgcccac gggcgagctg gaccgcgaac gattcgacct gcgacacctg
     5161 ctcgacgagc ggctcctggt cgcggtcgcg cgtgaccacc ggctggcgcg ccgccgctcg
     5221 gtgcgcctgg cggacctcgc cccggaagcg ttcgtcgtgg gctcggccac cgcggagaac
     5281 agcctgctcc gcgcaagcct gcccagcggt ttctcgccgc gcatcgacat cgtcgcggcc
     5341 gagtggaccg gcaagctggg atgcgtcgcc gccgggttgg gggtggccct ggttccggcc
     5401 ctggcggtac gcggaacccc gccggacatc gcactgctcc gcctgcaccc ggacgacgag
     5461 tcggtacggc agatattcgc ggcgaccgtg cggggcagga cgccgccgcc ggcggtcacg
     5521 cactttctcg agcatctgcg ggcggaggcg gcccatctgg gctgaaaagc agaacgccga
     5581 cctgcgtatc cgctggtcgg cgttcctgta gcccggcgaa aggctatgtg gccaggggcg
     5641 gggtcgaacc gccgaccttc cgattttcag tcggacgctc gtaccaactg agctacctgg
     5701 ccgtggtgct cggcacatgc taccgcacga gccgatacgc agaacgccgc gcattgagct
     5761 gcgcggcgtc agcgcttgcg gtcctgacgg gacttgaacc cgcgacctcc gccttgacag
     5821 ggcggcgagc actccaactg ctccacagga cctggctggt gttgcatccg gcgcgagccg
     5881 gaccgtgccc ccaacgggat tcgaacccgt gctaccgcct tgaaagggcg gcgtcctggg
     5941 ccgctagacg atgagggcgg ccccgccatc attgcacact cgcaacttca agcggacttg
     6001 ctcccatccg gccccgccgg aggcaggaga agcatatgtc atgtctgcac ggacggccaa
     6061 accggtatgg gcatggccgc gacgccgggc aaaaccgcag gtcagggtag tcgcgcgatg
     6121 ccgtaccgcc gcttcaggtc cgggatcagg tgccggcacg cggccatcgt ctgggcccgg
     6181 tcaccgcccg cgtcgtgcat cagcacgatc gagccgttcc gggtggcgcc cttcacccgc
     6241 ttgatgatcg tcttcgccgg cgggtggtcc cagtcctgcg ggtccacgct ccagtgcagc
     6301 gggcgcaggc ccatctgccg ggccaccacg atctcctcgg cggtccaccg gccgccgggc
     6361 tggcggaacc aggtgatcgg cgccttgggc gcggcggcgc ggatggcgtc gttggtccgt
     6421 tccaggtcgg cccggatctc ggtggccgac cgccggccga ggttcacgtc gtggtgccag
     6481 ctgtggttgc agagctggtg accctcgcgg acgatccggg ccaccagctc cgggtagcgc
     6541 ttggcctgct ggccgaccac gcagaacgtc gcggtgaccc gggccgcccg gagctgggcc
     6601 aggatctgcg gggtgtagcg gggatccggt ccgtcgtcga aggtgagcgc caccccgctg
     6661 ctcccgctgg cccggtgcag gcccgccggg agcttcttgg gcaccgggcg cagcttcggc
     6721 ttcctggggg tggcggtcgg ggtcggtgag ggcttcgtca cgggcgacgg cgacgccgag
     6781 accgacggcg aggccgccgc ctgatcgggt gacttgccgg cttcgccgca ggcggtgacg
     6841 aggagcacca ggcccagggc gagcgccggc agggcgcgtg gacgcattcg tcgctcccgg
     6901 aggggtcggg gtcagacgga ctttccgacc gtagtggacg cgccccggag cgaaaagggc
     6961 cgtcagccct tcgtcgactg gtccagcgag tcccgtaccg ccagggcgag ggagagcgcc
     7021 tcggccagat ccaccggccg gaccaccccg gccggcagcg agtcggcccg ccagccgggc
     7081 ccggcggcga gcaccagcag cggccggcgg gggacggtca gcagcgcggt gagctggcac
     7141 gggtcggcgg tcgcgcgggt gtgcgaccag aggaccacgg ccgccggccc ggtccggttg
     7201 accgcctcca ccagggcggg caacggcacc cgggcgccga gcatgcgaca gctcacaccg
     7261 gcctccgcga gcgcggcggc gagcgcctcc agcggcaacg agtgctgttc ctcgtcggcg
     7321 caggagagca ggatccgggg cggtccgccg ttcgggtggg cccggatcac cgtggcgaac
     7381 gccaccgaga cgcaccggga catcaggtgt tccacctcga tcaggccggc ggtggcggcg
     7441 tgccgttccc cgatcccggt gagcaccggc cggagcagcc cctcccaggt cgccaccacc
     7501 ccgtcggcgg cgagcgcctc ggcgatggtc cgcgcgatgg tcaccgaatc caggcgcatc
     7561 gcggcacggg ccagcccccg tgcggcgggg ccggcccggc cgaccgggat ggtcgtgccg
     7621 ccgccgtcgc gtaccgccga ggtccgtgcc ttgagcgcga gccggtccgg cggcggcacg
     7681 gccggggcct gccgggccca gcgggccgcc tcggcgggcg ccaccccctc ggtggtcagc
     7741 cggcgcatga tctccaggcg ggcgaggtcg gcgggcgtgt agcgccggtg gtggcccggc
     7801 acgtgctcgc tgggaccgag gccgtaccgc tggtgccagg tgcgcagcgt ggtgaccgcc
     7861 acacccaacc ggcgtgccac ggcccccgcg ctcagcgcct catcggccac ccgaccgctc
     7921 cggtgcctcg gaggccgcga cgcccggccg ggccgggccc gccggatgca gcagccggtt
     7981 gaccacgccg cccagccacg gggcgtacgc gcgggggtcg gcgtccaggt cggccaccac
     8041 cgcgccgggg tcggcccagc gcagctcggc cacctcgtcc ggatcgggcc gcgtcaccag
     8101 gtcggcgggt acgtcggcgc gcagcacgtg gtcgtactcg aactcgacgc ggccggtcgc
     8161 cgggtcctcg gcgtagtaga tgtagacgcc cacctcggtg agctcgaccg ggccgacgcc
     8221 gagttcctcg ccgagccgcc ggttggcggc ctcggtcagc gactggcccg gcagcgggtg
     8281 cccgcagcag gagttcgccc agcgcagcgg gaaccgcgtc ttcaccgcgg cccgctgctg
     8341 cagcagcacc cgcccctgcg ggtcgaccag gagcaccgag aaggcccggt gcagccggcc
     8401 gggtggctgg tgggcggtcg ccacggtggt ctcgccgagc acctgcccgt cgtcgccgac
     8461 cagctcgacc aggtgttcct cccgctcgct catgccgtcg ccccggtgat ccgggccgcc
     8521 gcgagcttgc cgctgatcag caccatcggt acccccacgc ccggctgcgt gccggagccg
     8581 acgaagacca cgttgtccag cttccggtgc aggttggagg ggcggaacgg cccggtctgg
     8641 aagagtctgt gcgcggcggc gaacggcgtg ccggcggcca tgccctgtgc cgcccagtcg
     8701 gccggggtga cggcccgcat cacctcgatg ccgtcgccga agccgacgta tccgcgttcc
     8761 tccagcgtgc ctacgagctg gtcggcgtac cgctgggtga ggtcgcccgt ccagtcgagc
     8821 ggcgcccgct ccaggttcgg caccggcgcc agcacgtagt aggtgtgctt cccggccggc
     8881 gccaccgacg ggtcggtgcg gctcgggttc gtcaccagca gcgacgggtc ggtcatcagc
     8941 tcgcctcggc ggatcacctc gtcgaacgtc cccttccagg agcgcccgaa gtggatgttg
     9001 tggtgggcga tcttgccata gccctgcgtc gaaccgatgt gcagcaccac gcaggacggc
     9061 gagtaggtga gcttgcgttg ccggctgggc ggcagcaggt cctcgtaggc gaccggcagg
     9121 tcggggttga gcaccaccgt gtcggcgggg acgaagtcgc cgtcggaggt gatcacgccg
     9181 gtggcgcggc cgttggcggt ctccacccgg gtcaccgtgg tgccgtaccg gaactgcacg
     9241 ccgtgcttct cggccgcgcc ggccatcccg cgggagaccg cgtggatgcc gccgcgcggg
     9301 aagcagacac cggccaccga gtcgaggtac gcgatgaccg cgtagatcgc cagcgcgtcg
     9361 tgcggcgaca ggcccgcgta catggcctgg aaggagaaga tccgctgggt acgcgggtcg
     9421 cggaagaact ggttgatctt cgtctggagc cgccggaagg cgccgttggc gaacaacttc
     9481 agcaggttgc cggtgagcag gtcggtcggc gcgtcgaggt tgcgctcgat gaagtcggcc
     9541 cgttcccact gccacaggtt gcgggcgtag tcgacgaaac gcaggtagcc gtccgcctcc
     9601 cggggaccgc agacacgcgc gatctcggcc gccatccggg tggtgtcggt gatgacgtcg
     9661 agcgtcgacc cgtccgggta gtaggcgcgg tacgccgggt cgagcgggct caggtcgagc
     9721 cagtcggtca gctcctcgcc gaccgcgccg agcgcctcgg cgatcaggtc gggcatggtg
     9781 aggacggtcg ggccggtgtc gaactcgtac ccgtcgacgc tgagccgccc ggcgcgcccg
     9841 ccgggcaccg gctcgcgctc cagcaccgtc acctgccggc cgctgccggc caggtgcagc
     9901 gcgcacgcca gcccacccag cccggcgccg accaccacca cccggtcggt ccgtcccttg
     9961 acggtacgca ttccggcccc cttgctcgcg aagttgctca tcatgcccgc cgtgcggtgg
    10021 cggcggtggc gagacccgtc agcgcggtgc gcgcggtctc gtcgatcggt gcggtgccga
    10081 gcgcggcgag cgcctcggtg acccggtcgg cgatcatccg ttccacccgg gcggtggcgc
    10141 cggtgtcgcg gaccacgtcg gccagccggt ccacgtcgcg tgccgtggtg accgagccgg
    10201 cccggtccag cgcccggcgc tgcgccgggt cggcgagctg ccgggccagc atcagcaggg
    10261 cggtcggctt gccggtacgc aggtcgtccc cggccggctt gccggtggtc tccgggtcgc
    10321 cgtagacgcc gagcaggtcg tcgcggagct ggaacgcctc gccgacggcc agcccgtacc
    10381 gggtgtacgc ggcgatgagc gggtcgtccg ggtcggtgcc ggccaggcag gcgccgaaga
    10441 gcagcggccg ctggacggtg tagctggcgg tcttgtaccg ggccacccgt agcgcccggt
    10501 cgactgtcca gttccccgcg tcgttctcgc cgagcacgtc caggaactgc ccggcgaccg
    10561 tctccacccg catctggtcg tagcagcggc gcacgtcgag cagccgctcg gcggggaccg
    10621 ccgcgtggcc caggagccgg tcggcccaca ccatgcagag gtcgccgatg agtacggcga
    10681 ccgcttcgcc gtaccggtcg gggtcgcccg cgtgcccggc ggcgcggtgc cgggcggcgg
    10741 cggcccggtg cgcggtcggc agcccgcgcc gggtgtcgga agcgtccatc acgtcgtcgt
    10801 gcacgagcgc gaacgtgtgc agcagttcga gggcggacag ggccgggagc accgaacaca
    10861 tcggttcctc cccgccgaca gcgccccgcc atccccagta cgcgaacgtg ggccggaccc
    10921 gtttgccgcc ggccagcacg cagtcgcgcg cggttgcggc gaatgcaccc atcgctgcgt
    10981 cgatctcggt cagcgaatcg acttccgcgg ccaggaacgc caccagcgtc ttatcgaccc
    11041 ctttgatcag gtctttcgtg aacgcggcca gtacgccgcg gaccggatcg tccgtcgccc
    11101 cggcctgagc cggcgcgacg cggagcgcat tacccgcaac tgcgtcgttg gccatgtggg
    11161 cgagcgtacc ctagggttac gagttgcgtc gattgctgcg tcgaaactga ggagggccga
    11221 tggacgtgga tctggccgcc gcctatgacc gctgccgcga gctgcaccgg cgtcacggcc
    11281 gtacctacta tctcgccacc cggctgctcc ccgcctggaa acggcgacat gtgcacgcct
    11341 tgtacggatt cacccgctac gcggacgaga tcgtcgaccg caccgaggac ctgccgcccg
    11401 ccgagcgcgc ggcccggctg cgcgagtggt cggatcgatt cgtggccggg ctgcacggcg
    11461 cgtcggtcga cgacccgctg ctccccgccg tgctgcacac catcgccgtg ttcgacctgg
    11521 actgcgacga cttcgcgtcg ttcctgcgca gcatggcgat ggacctgacg gtgatgtcgt
    11581 acccgaccta cgacgacctg ctcgactaca tggagggctc ggccgccgtc atcggcacca
    11641 tgatgctgcc gatcctgggc agctccgacc cggccgccgc ccgggagccc gcccgccagc
    11701 tcggcttcgc cttccagctc accaacttca tccgggacgt cgccgaggac ctcgaccggg
    11761 gccggaccta cctgcccgac gaggatctgg ccaagttcga cgtcacccgc gccgacctcg
    11821 tcgcggccaa ggccgccggt cgcaccacgc cgcgcatccg cgagctgatc gagtacgagg
    11881 tgacccgcgc gcaggcccac tacctcgccg ccgcgccggg catcccgctg ctcaaccccg
    11941 cctcgcaggc gtgcatgcgc accgcgtacg cgctctacgg cggcatcctg gacgaggtcg
    12001 ccgcgcagga ctacgacgtc ttcgtccgcc gggccctggt gccgcagcgg cgccggatgg
    12061 cggtggccgc gcgggcgctg ctcaccccgc ccggcacgcc ggttcaggtg cccggcccgg
    12121 cgctggaacc ggccctggcc ggatgaccgg ccggacggcg gtcgtgctgt tcacccgcga
    12181 cctgcgggtg cacgaccacc cggcgctggc ggccgcctgt tccgcgttcg agcgggtggt
    12241 gccgctctac gtgctcgacc cggagttgca gcagctctcg ccgaaccgca cccgcttcct
    12301 gcaccagagc ctggccgacc tgcgcgaggc gctgcgcaag cgcggcggcg acctggtgat
    12361 caggcgcggc gacccggtgg ccgagacggt gaagctggcc cggaaggtgg gcgccgaggg
    12421 cgtcgggctc tccgccgacg tcagccacta cgcccgccgc cgggaacgcc gcctgcgcgc
    12481 cgagtgcgac cggcaccgca tgttcctgcg gttgttcccc ggcctgacga tcgtcgagcc
    12541 gggcgcgctg cgcccgagcg gcggcgacca ctaccgcgtg ttcagcccct acttccgcgc
    12601 ctggcagggc gtgcgcctgc gggacgaact ggccgcgccg aagcgggtcc ggctgcccga
    12661 cggcgtcgac ccgggccgcc cgcccgaccc gccgaagggc gacagcccgg ccgccgccgt
    12721 gggcggggag aacgccgccc gccgccggct caccgcctgg ctgcccaccc tcgaccggta
    12781 cgacgacatc cacgacgaca tggccggcga cgagacctcc cggctcagcc cgtacctgcg
    12841 cttcggctgc gtctccccgc tggcggtggc gacccgggcc ggcgaccgcg acggcccgtt
    12901 cgtccggcag ctctgctggc gcgacttcta ccaccaggtc gtcgccggat tcccggacct
    12961 gtccacggcc gcctaccggc ggggcgcccg ggaggactgg cggtacgacg agcacgcgct
    13021 cgacgcctgg accgagggac ggaccggcat gccgatcgtg gacgccggca tgcgtcagat
    13081 gcgcgccgag ggctggatgc acaaccgggc ccgcctgatc accaccggct acctgaccaa
    13141 gcacctcggg ctggactggc ggcccggcct ggaagtcttc ttccggtggt tgctcgacgg
    13201 cgaccgggtc aacaactccg gcaactggca gtgggtggcc ggcaccggca acgacacccg
    13261 gccgtaccgc ggcttcaacc cggtacggca ggccgagcgc tacgaccccg acggcgcgta
    13321 cgtgcggcgg tgggtgccgg agctggaatc ggtggcgggc aaggcggtgc accagccgtg
    13381 gcggctgccc gacgctgtgc gtcgcacgct cgactacccg ccgccgctgg aggtgcccgg
    13441 cgccgacccg gtctggctcc gctgacgccc tcgcctctcg ccgcgcgtcg cccgcgcacg
    13501 agcgcgaacg tcacacgagc ccaacgtcgc tggcgcacag cccgcgcggg tcgcggcacg
    13561 gcgcccacga ttactgcggg tgactgcacc tctagcccgc gccatccacc tccggccgac
    13621 tttgctctgc agccatatcc gcacccgttg cggaacgtga ccggtgcggg cctctcgcgg
    13681 atttcggacc tagcggaaat ccgctgctca actcggtgct gcgccaatgg gtgcagagca
    13741 aagtcggaaa aggggaagcc aggcgcgact gccggccgaa tgcgctgcgt gacgacgcgc
    13801 cggaattaca gaacgtgacc gacggtcaga ggcaggagtg cagcgcctcg accagctcct
    13861 ctacccgatc gtggtcggcc agccgggcgg tcgcgtacgc gaaggtgtag ccccgctccg
    13921 ggtcggccca ggcgctgctg ccgccgatcc cgcccatgcc ccagctgccg tccggctccc
    13981 actgcatgcc gagcgtccag tccaccggcc ggtccagcag caggtccggc ccggaatact
    14041 gcacccgcgt cgcctcggcg accagctccg ggctgaacag acgtaccccg tccagggtgc
    14101 cgctggcgag caggcccgcg tacagccggg cgagcccggc ggcggtggcg tgcaggttca
    14161 ccgccgggat ctcggcggcc cgccagaggt cgctgttcac catcgcgacg tcgcgcccgc
    14221 cgggcgggtt gtccagcgcc cgcgcccgca acgaacccgg ctcgccgcgc atcgcgtccg
    14281 gccaggccgg atcggcgtac gacaggtcgg cgcaccgccg ccggtcggcc tcacccagcc
    14341 cgaaggccag gtccaggcgc cacggaccgg cgatctcctc ggccaggaac cggcccaccg
    14401 gccgcccgtc cacccggcgg accaactcgc ccaccaggtg cccgtacgtc caggcgtgct
    14461 cgcccgcgac ggcgcccggg tcccactccg gctcggccgc cgccaggtcg gcgcagagca
    14521 ggccccagtc ggcgatggcc gcggcggggc ggggcaccgg gaaggcgggc agcccggcgg
    14581 tgtgggcgag gacctgccgg acggtcgccg gggtgcggaa ctccggccag tacgccgaca
    14641 ccggcgtgtc caggtcgacc cggccccggt cgacgagcag cagcagacag agcgccacca
    14701 ccggcttgcc ggtcgagtag acgtccacga gcgtgtccgg acgccacgcg cggtccgccc
    14761 ctgccatcgg tgcgaccgca ctgggcggga ccgccgccgc cgtgccgccc atcagctcga
    14821 tcaccggtac gccgtcgtgc cacaccgcga gcgacgcgcc ggtctcccgg ccggtgacga
    14881 acaggtcgtg gaagcagtcc cggaccgggg tgaagcgcgt gtgcatgcgg ccacggtagg
    14941 cggtcgcgtt cgtgacgagc gcgggaattc ggggccggtg cggtggccgg tgtcccgaag
    15001 gtacggaatg cttgcggaat ggcggagccg gaacaggttg acgtagtagt ggtcgggctc
    15061 ggcgtcggcg gcgaggaggt ggccggacgg ctcgccgagg ccggcctcac agtggtcggc
    15121 atcgaacggg acctggtcgg cggcgagtgc ccctactggg ggtgcgtgcc gagcaagatg
    15181 atgatccggg cggcgaacgc gctggccgag gcgcaccggg tcaacgagtt ggccgggtcc
    15241 gcccaggtgc ggccggactg ggcgccggtg gcgaagcgga tccgcgccga ggccaccgac
    15301 acctgggacg acaaggtggc ggtggaccgc ttcaccggca agggcggccg gttcgtccgg
    15361 ggcagcgggc ggctcgacgg cccgaaccgg gtacgcgtcg gcgaccaggt gttcccggcc
    15421 cggtacggcg tggtcctcgg caccggcacc cggccctcgg tcccgccgat cgacgggctg
    15481 gccgacacgc cgtactggac gaatcaccag gccatcgagg tagaggaact gcccgcgtcg
    15541 ctgctgatgc tcggcggcgg cgcgatcggg ctggaactcg cgcaggtctt cgcccggttc
    15601 ggcgtgcggg tgacggtcat cgaagcggcc gaccgggtgc tcgccgtcga ggagccggag
    15661 gcgtcagcgc tcgccgccga cgcgctgcgc gccgacgggg tggagatcca caccggggtc
    15721 aaggccggct gggtcggcca cgacggcggc gcgttcaccg tgtacgccga cggcgccgag
    15781 ttcaccggcg agaagctgct cgtggtgacc ggccgcaagg cgcacctgga ggagttgggc
    15841 ctggacacgg tcggggtgga cgccgggcag cgctacctgc cggtgaacga ccggatgcac
    15901 gtcaccgacg ggatctgggc ggtcggtgac ctcaccggtg agggcgcgtt cacccacatc
    15961 gccatgtacc aggccggcat cgtggtggcc gacgtcctcg accacatgcg gcgtaccaag
    16021 ggcggcccgg acgccagcgg caccgcgagc gtggtcggcg gcgcggccgg tgtggtcagc
    16081 tcggtcggcg gcgcgatgag cgcgggcggg tcgagcgtcg cgccgggcag cgtcccggtc
    16141 gccgactacc gggcgctgcc ccgggtcacg ttcaccgacc ccgaggtcgg cgcggtcggc
    16201 ctcaccgagc agcaggcccg cgagcgcggc gtcaacgtcc aggtcggata cgccgatctc
    16261 acctcgtcgg cccggggctg gatccacaag accggcaacg ccgggttcat caagctggtc
    16321 gccgacgccg accagggcgt gctcatcggg gccacctcgg ccggaccggc cggcggcgag
    16381 gtgctctccg cgctcgtcgt ggcggtgcac gcggcggtgc cgatcagcca gctccggcac
    16441 atgatctacg cgtaccccac gttccaccgg gccatcgagg acgcgttgcg cgccctgaag
    16501 tgacgcctca gccggccggc gcaccgtggc ggccggcccc ggcggcgaac cggccggccc
    16561 cgcgtacccc gtccaccgcc agcgactcca tgccgtaggc cagctcggtg gccatcgcct
    16621 ccggctccgg ccgccccgcg ccgtccagca ccgccgcccg gtcgttgcgc aggcacgtct
    16681 gcggatgccc ggcgatcgcg gcggccagct cctcggccgc cgcgcgggcc gcacccggcg
    16741 cgacgagccg gttgaccaga cccatcgcgt acgcctcgtc ggcgccgacc gggcgtccgg
    16801 tgaggatcag gtccatcgcc cggctctcgc cgatcagccg gggcagccgg accgtcccgc
    16861 cgtcgatcag cggtacgccc caccggcggc agaacacgcc gagcgtcgcg tccgactcgg
    16921 cgatacgcag gtcgcaccag agcgccagct ccagcccgcc cgccaccgcg tacccggaga
    16981 tcgccgcgat caccggcttg gacagccgca tccgggtggg gcccatcggt ccgtccccct
    17041 cgggctcgac gcggttgccg cgcggcgtgc cgacggcctt cagatcggcg ccggagcaga
    17101 acgtgccgcc cgcgccccag agcaccgcga ccgccgcgtc cgggtcggcg tcgaacgcgc
    17161 ggaacgcgtc ggcgagcgct cgtgcggtcg gcccgtccac ggcgttacgg gcctcgggcc
    17221 ggtccaggat cacagtggtc acggcaccgg cgtgctcgac gcgtaccccc atgggctcag
    17281 catgcccgcg acggcgctgc cgtggctacg ccctatttga tcgagccggg tcgggtcagc
    17341 cagcgcatcg gctggccggt gacggcgccg acctggtcga agtcccggtc gtagtgcagc
    17401 agcgagaggc cgtggtactc ggcggtggcg gcgatgagca ggtcgaccgc gcccgccgag
    17461 cggtgcgtcc cccgcacggt cagctcgccc tggacctcgg cggcgcgttc gtagatccgg
    17521 tccggcatga ccacccagcc gaaggcggcc cggagctgct cggtcaggcg cgtccggtcg
    17581 gcgaccgacc gggcggtgta gaggaattcc agctcgacca gcgggcacac ggcgagcaga
    17641 cccgctgtca cctgctgttc ccagcgagcc agcacgtcgg gatcacgcag gagccggacg
    17701 agggcgctgg tgtcgatcag gtagtcggcc agcttcacga gcggtaggcg cccttgtcga
    17761 gcagttcgtc gaagtcaccg gcctgcccgc gctcggccag gtccgccagc gcccgggcgc
    17821 ggcgcagtct cgccgcgccc tcgcggagag cgacgttcac cgtgtccttc ttggtcttcg
    17881 tgccgaacgc ctcggcggca tccgccagcg cctcgtcgtc gacgtccacc aggatcttgg
    17941 tcatcgcggc tccctatata cgatcagcag cctgagtata tccagcgcgg aggtcgtgcg
    18001 agggaattcc ggggcgtccg gtttgggggc tctcctgccg ggaagtcgga acgggtgcgc
    18061 gaactactga cgaagatcga acaggccacc ggtctcgacc gggtgggtga ccggttgcag
    18121 cgcgccgtcc agggcacgtt gcgttcccag cgggtacgcg acgcgctgca cggcgtgtgg
    18181 ctcggccatc cgctgcaccc cgcgatggtg caggtgccgg tcggtgcctg gatctccgcc
    18241 gccgtggtgg acctgctgcc cggccaacgc cgggccgcca ccgcgctggt gggtctcggt
    18301 acggtcagcg cgctcccggc ggcggtcgcg gggctcaacg actgggccac gctctcccgc
    18361 gaccagcgcc ggatcgggct ggtgcacgcc gcagccaaca cggtcggcct ggcgctgtac
    18421 gccggttcgc tggcggcccg cctcaacggg cggcacggcc tcggccgggc gctgtcctac
    18481 ctcggtctgt ccgccgccag cggtggcgcg tacctgggtg ggcacctcgc gtacaagcag
    18541 ggcgcccagg ccagccagag cgtctccgag ctgcacctga tcagcgacgg ctggcaccgc
    18601 gtcggcgacc tgagcagcct gccccggcac gaactggtca ccaagaagat cgacgacgtc
    18661 tcggtgatcc tctaccggga cggcgacgac gtcacggtca tgctggagcg ctgcccgcac
    18721 cagagcggcc cgctcggcga gggcactgtg gagcagatcg acggccacgc ctgcgtggtc
    18781 tgcccctggc acggcagcgc gttccggctc aacggcggcg aggtggtgca cggcccggcc
    18841 gcgaacgacc agatcgtgct ccccacccgc gtggtgtccg gccgggtcga ggcccggctg
    18901 ccctgactca gtcccgccgg tgccgcccgc tggaacccgc gcgggcgggc accggccgct
    18961 tgcgcaaccc cagcagcgcg ccgatctgcg cgcccacgat gctcgcgacc gccagcaccg
    19021 ccgagatggc gagcggacgg ttgatgccct cctcggcggt gggccgggac gcacccgccg
    19081 acatggccgg cggctgaccg accggcgcct ccacggtggg cgtcgcgtcc cgcggggtgg
    19141 gcttcggctt cgcctgcggc gcgctcgacg acgcgccgcc gccacccggc ttgaccggtg
    19201 cggtctgggc cggcttggtc accaccagcc gcccggtggc gtgccgccgg gcgccggagt
    19261 ccgtcgcgcc gtccggcagc gtgatgagct ggccggggcg gatccggtcc gggtcggcga
    19321 gccggttcag ccgggccagc tccttgtacc tgtcgaagtc gtccaggtag cggtcggcca
    19381 cctcacccag gtagtcgccc ttcgccaccc ggtacacggc cgggtcgtcc gccttcgacg
    19441 cgaccggggc cggcggcgcg acccggctcg gcgcggtgac ggcagaagcg gcgaccgccg
    19501 gctgcggggc ggtcagcgcg gcggcgctcg ccgcggccgg gctcgcggcc aggatcagcg
    19561 cgaccgaacc gacgagcgcg gctgcggcct tctgctggcg gtgcatgccg ggcagcttcg
    19621 gcgccggccg gcgtaccgca gccgcgagca gctccaccac gacggagaac gcgaacgtgg
    19681 cccagccgaa ccagcccacc accgccagcg cgcgcaggaa cagttgaccg tcgtcgcggc
    19741 tggtcaacgt cgtaccgatc tcggcgaacg tgggcaggtg atccggcagc gggttgccgg
    19801 cgaacgccag cagcgcgacc ggcccgccgg ccagcacgcc gacgagcacg acgagggcgc
    19861 cgaggccggt gagaacctgg ccggcgcggc ggacggggga gcgtcggggt gcgcccatgg
    19921 cggccttccc ttcctacggt gggccggtga gcgcccgagc ggtggcctca ccggtgacgg
    19981 tggcggtgtt ctgcacgccg aacagactca gcaggtcccg gctgtaggtg atctgcacgc
    20041 tcacccggat ctgggtctcg gcgccgacca cggggaagtc gacctcgtgg tcctggacgc
    20101 cgcccgccgc gtcgaggtag gcggcgaccg cggcgcgggc ggcgacctgg tcgatctgct
    20161 tcgggccgcc ctcgatggcc cgcgcgcggt cgatcatctg gccgccggcg cgggccgcct
    20221 cggcggccag gttgtccgcg cgttggagcg tgcgcagctg gccggcgccg tcgtaggcga
    20281 ggctgatgat cgccagtacg ccggtcatcg ccacggccag gaagagactc acccggccgc
    20341 tctccgccgc gcgccgcccg gtcatccgcg actccggtag gtgtccagcg gcgaggtgaa
    20401 cctcgccgag acggtcttgc cgcccggcac gccgggcagg ccgggcgcgc tcaggtcgtc
    20461 gaaggagacg gtgcaggtca cagtgaccgt cacggtcgcc ggcacgcctg cggcgctcgc
    20521 gtacgcggcg gcgaagctcg tcgtcgtacc ggccaccgag cccgcgaggt cgagctgggg
    20581 tggaccggag cagttcagcc ccgcccagcc gagctggttc cgggccgcct cctcggcggc
    20641 ctccgcgccg tcgtcggcgt tgcgggcgag cgaggcggcc cgggcggcgt cgtgcgcggc
    20701 cgactccacc gcctcgtccg cgatcgcggt ccgcccggcg accccggcca gcaccatcag
    20761 cccgatgaag gcgggcgcga gcaccgccac ctcgatcgag acggaacccc ggtcccgccg
    20821 cggcccggcg ctcatccggt ggtccagcgt tcggccgggc cgtgcgcggt ctgcgtgacc
    20881 gcgaacgaga cacccgggat gaccgacagg gagcgcccct gcaccgtgca ggtgacggcg
    20941 gtggcgctct cgacgcacgt cgggccggtc tgctcccagt cgaccagcca gtccccggac
    21001 tgctgcagga agctgatcgc ccgctcccgg ccggcgtccg gcccggcgtc gatcgtgcgc
    21061 tgggcgttca caccggtctg cgcggcgttg agcgccgtgg accgggccac gaaccagacg
    21121 gcgacctgga tcgagccgaa cagcatcacc aggatcaccg gcatcaccac ggccagctcg
    21181 accggattgg cgccccgctc gccctcggcc agacgggcgc gcagagcagc ggcgatccgc
    21241 cccggaccgg gcggaccggc gggcgccggc cggctccgga ccgtacgggc ggggcggggc
    21301 atcacggggc ctgcggcgcc gtgttgttcg ggatggcgtt catccagttg ttcgccttgg
    21361 ccagggccag cccggtgacc gccatggcca ccgcgaccag gccgaagatg atcaccgcgg
    21421 tcggcaccgg gctgtcgccg cgctcggagt cccggcgcag ctcggcgagg cgggtgctca
    21481 ccgccacgta caggtaggcg tagaggtgca tggtcgtctc cttctcgatg gggttcacag
    21541 acgggcgagg aacggataga cggcgaagcc gagcaggacg aacaccagca gcgagccggg
    21601 gatgtccaac ttgctggtga ccccctcggc ccgggccagg ttgtcggtac ggatctggtc
    21661 gcgcagcgag tcggcacggg accgcaacgt ctcgtgcacc tgggcgccct cgctgccgga
    21721 ggagcgcatg atcgcgccca cgtcgcccag ctccgggatg ccgatccggt cggccagctc
    21781 ctgcaactcg tcccagggcg agtgcatctg gagctgggcg agccgcagcg cctcccggat
    21841 ccggtcgaag acccagccgt cgcagaccgc cgccgcgcgt tccagcgact gcaccgggcc
    21901 gtgcgcggcg gacagctgca gcgccaccag gtcgaggtag gtgcagaccg cctgccggaa
    21961 ctcgtcccgg gcggcgtcgg cgttggcgag gaccgagcgg tgcgcgagca gtccggcgcc
    22021 gagcgccaga cccaggctgg ccaccaccgg cacggccagc ggcagcgcca ccccgccgac
    22081 gaagagcacc gccgaggcga ccgccggggt ggcgaacccg acgagcgcgg agagcagcac
    22141 cgacag
//
