LOCUS       NZ_BBVA01000005        22119 bp    DNA     linear   CON 10-SEP-2024
DEFINITION  Micromonospora sp. NBRC 110037, whole genome shotgun sequence.
ACCESSION   NZ_BBVA01000005
VERSION     NZ_BBVA01000005.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Micromonospora sp. NBRC 110037
  ORGANISM  Micromonospora sp. NBRC 110037
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Igarashi,Y., Komaki,H., Ichikawa,N., Hosoyama,A. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Micromonospora sp. NBRC 110037
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 463339)
  AUTHORS   Hosoyama,A., Ichikawa,N., Kimura,A., Ohshita,R. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 106x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001652995.1-RS_2024_09_10
            Annotation Date                   :: 09/10/2024 02:06:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,195
            CDSs (total)                      :: 6,136
            Genes (coding)                    :: 6,073
            CDSs (with protein)               :: 6,073
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 15 of 63
            Pseudo Genes (incomplete)         :: 53 of 63
            Pseudo Genes (internal stop)      :: 4 of 63
            Pseudo Genes (multiple problems)  :: 9 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 107726
            Orig. end                         :: 129845
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBVA01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22119
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..22119
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22119
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12119](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12119)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(1125..2105)
                     /locus_tag="A4R25_RS31490"
     CDS             complement(1125..2105)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS31490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_147265147.1"
                     /transl_table=11
                     /translation="MFTPAQLGLDDPARYVEAEERFSRTASECAASANVAGEGRALLNT
                     AWAVEKQGRGAEAIKLAETARHLLRDSEALSALAECCHSIGVWRFHHFDDDPPVNDFRE
                     AIQVRLGTGDLMAAAQSWHNMGYVQLASGDVAGAWSSYEHATDLLRQVRDGGDTELASK
                     AFRQFGFILSHQAFAAARHDSARAALQATGRYFDHVRLTGAHREPVYAYLAPGIALAAS
                     REVPEDEANALEALVGIAPDPESWLLAAVRQATDAMTSPVDTGTGRHAYLGARILALAE
                     LARWHHMAGRGREADELVDLAVNLSRARGWHGEAVRAARVSEGSS"
     gene            2551..5670
                     /gene="ileS"
                     /locus_tag="A4R25_RS16810"
     CDS             2551..5670
                     /EC_number="6.1.1.5"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004822 - isoleucine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006428 - isoleucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ileS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018739643.1"
                     /locus_tag="A4R25_RS16810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isoleucine--tRNA ligase"
                     /protein_id="WP_064447337.1"
                     /transl_table=11
                     /translation="MYRAVPAQASFPDIDHGILKFWSDRKVFALSLERSQGRPEWVFYE
                     GPPTANGMPGAHHIEARVFKDVFPRYKTMKGFHVARKAGWDCHGLPVELAVERELGFSG
                     KRDIEAFGIAEFNARCRESVTRHTDEFARLTERMGYWVDMDDAYRTMDPEYIESVWWSL
                     KQIFEKGLLVEDFRVAPWCPRCGTGLSDHELAQGYEVVTDPSVFVRFPLTSGPLAGQAS
                     LLVWTTTPWTLVSNVAVAVNPDVTYVVMTDGQEQLVVAEALAGSALGEGWTVVGDSFSG
                     KDMERWTYRRPFDLVQVEDANFVILGTYVTTEDGTGLVHQAPAFGADDLAACRAYGLPM
                     VNPVRPDGTFQSDLALVGGTFFKSADAVLVADLAERGLLFREEAYEHSYPHCWRCHTAL
                     LYYAQPSWYIRTTAIREALLRENEATTWQPQNIKYGRYGDWLNNNVDWALSRSRYWGTP
                     LPIWRCPDNHLTCVGSLAELSELAGTDLSELDPHRPYIDDVTFDCRCGATARRVPEVID
                     AWYDSGSMPFAQFGYPHKNVELFEKRYPANFISEAIDQTRGWFYTLMAVGTLIFDKSAY
                     ETVVCLGHILAEDGRKMSKHLGNILEPIPLMDEHGADAVRWFMAAVGSPWSARRVGHNT
                     LQEVVRKTLLTYWNTVSFGALYGRAAGWSPSAADPAPRSRPLLDRWLLSELNSLVRDVD
                     AAMERFDTHEAGRLLSTFIDDLSNWYVRRSRRRFWHGDPAALATLHETLSTLTLLLAPI
                     TPFVTERVWQDLVVPVTPGAAESVHLAAYPTGDLSLIDPELSAQMLLVRRVVELGRSAR
                     ADSGIRTRQPLSRAVVSAAGFADLPAELLAEIASELNVVSVAPITATSGSLVDTTVKAN
                     FRPLGKRFGKAVQGVAAAIMAAEPTALANALRTRGEATVDVDGEAVVVTVDEVVITETP
                     RAGWAVANDAGATVALDLDITPELRLAGIARDVIRQIQEARKATGLEVADRIELRYEAT
                     ADTLTALTEHQKLVADEVLATDFTLGRPTWADATSFTDETLGLTFWLRKA"
     gene            complement(5761..6309)
                     /locus_tag="A4R25_RS16815"
     CDS             complement(5761..6309)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007071158.1"
                     /locus_tag="A4R25_RS16815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavin reductase family protein"
                     /protein_id="WP_051611124.1"
                     /transl_table=11
                     /translation="MTAAKQKPVSRDRCGGDRHVDMRAVMGAFATGVTVVTSGRELPHG
                     MTANAFTSVSLDPAMVLVCVKQSAAMHSTILANGMFAVSILAAGQEELARYFASPSRPR
                     DEREFRTVDFRPGEHTGSPIIEGNLGWVECELAAVYEGGDHSIFLGSVLDIGHGDRTDA
                     LVFHTGRFSVLATDVHGVR"
     gene            complement(6420..6689)
                     /locus_tag="A4R25_RS16820"
     CDS             complement(6420..6689)
                     /NRPS_PKS="Domain: PP-binding (9-50). E-value: 2.5e-11.
                     Score: 35.7. Matches aSDomain:
                     nrpspksdomains_A4R25_RS16820_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="A4R25_RS16820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_069087898.1"
                     /sec_met_domain="PP-binding (E-value: 1.9e-10, bitscore:
                     35.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSSEVLETVSGFWRELLETDAVDVDHDFIAAGGDSLLAVELLAR
                     LEGTFPDAGFDDPANVGWLTIRATAEQIVARSSTRSAIDAGSGD"
     aSDomain        complement(6540..6662)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS16820_PP-binding.1"
                     /evalue="2.50E-11"
                     /label="A4R25_RS16820_PP-binding.1"
                     /locus_tag="A4R25_RS16820"
                     /protein_end="50"
                     /protein_start="9"
                     /score="35.7"
                     /tool="antismash"
                     /translation="VSGFWRELLETDAVDVDHDFIAAGGDSLLAVELLARLEGTF"
     gene            complement(6700..8271)
                     /locus_tag="A4R25_RS16825"
     CDS             complement(6700..8271)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (20-419). E-value: 1.2e-60.
                     Score: 197.1. Matches aSDomain:
                     nrpspksdomains_A4R25_RS16825_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="A4R25_RS16825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_064447338.1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-58, bitscore:
                     193.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTRGAGGATDRCTGTFGLLERVAGEVPDRLALVEPFVRGLTFAE
                     WLHDSVALAARLSEAGITSGMRVGLLFDRRHWIDLCVAYFAVQRLGAVTVTVSAGAPVS
                     VRDFITQDAGISAWIAADSSPVGNGPGGDPYQVLPVEPPRCGDRVPPPATTRPEQTADI
                     LYTSGTTGLPKAVVTPHALFTEVYARPPSAHGGIGPPILHAFPIGTAAALMMLYAPFQG
                     IDGPGLTHPITRAVAALPEFNTNDVCKAVADCQVTLLFLTPAMLAHLTTLTSSQREMLA
                     SLEVIHCGSAPLNPAHVERIRRMLPSVRVVNAYGTTEAWPAMVEMPSAGADPDVVGRPA
                     RGTRIRIRSLETGLVVGPGVHGRVEMSCPRFRGRRSYLHDSVPSKTFLPDGWTATGDIG
                     HLDEEGNLHLSDRVSDVLNVGGEKLSARPVEIALLSHPMVEAAAVLGLPHPRLGEYVAA
                     VVVLRPGRTSLNDIRVHLLERLPPKQIPRRVFAVGSMPVTENGKILKNDLKNSIARGEG
                     TLSELR"
     misc_feature    complement(6748..6750)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(7015..8211)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS16825_AMP-binding.1"
                     /evalue="1.20E-60"
                     /label="A4R25_RS16825_AMP-binding.1"
                     /locus_tag="A4R25_RS16825"
                     /protein_end="419"
                     /protein_start="20"
                     /score="197.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ERVAGEVPDRLALVEPFVRGLTFAEWLHDSVALAARLSEAGITSG
                     MRVGLLFDRRHWIDLCVAYFAVQRLGAVTVTVSAGAPVSVRDFITQDAGISAWIAADSS
                     PVGNGPGGDPYQVLPVEPPRCGDRVPPPATTRPEQTADILYTSGTTGLPKAVVTPHALF
                     TEVYARPPSAHGGIGPPILHAFPIGTAAALMMLYAPFQGIDGPGLTHPITRAVAALPEF
                     NTNDVCKAVADCQVTLLFLTPAMLAHLTTLTSSQREMLASLEVIHCGSAPLNPAHVERI
                     RRMLPSVRVVNAYGTTEAWPAMVEMPSAGADPDVVGRPARGTRIRIRSLETGLVVGPGV
                     HGRVEMSCPRFRGRRSYLHDSVPSKTFLPDGWTATGDIGHLDEEGNLHLSDRVSDVLNV
                     "
     CDS_motif       complement(7732..7785)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R25_RS16825_0001"
                     /evalue="2.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="A4R25_RS16825"
                     /protein_end="180"
                     /protein_start="162"
                     /score="20.3"
                     /tool="antismash"
                     /translation="ILYTSGTTGLPKAVVTPH"
     gene            complement(8268..9152)
                     /locus_tag="A4R25_RS16830"
     CDS             complement(8268..9152)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS16830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157539098.1"
                     /transl_table=11
                     /translation="MENEGSDTIRISAPALGRSWRLDAGRVERLLHQVVAEEFEDPAVQ
                     QLIRLGLLVEREGADGTSWGPVRRYHAWSGIDHFRDGADSTGGLRASALRLFSQDDLDA
                     LREPAVPQGRREQIPEPWAAVVWTALTRVRANRRRLREAVHPAELLYSYGAAHGLLIVS
                     RVDGRVLVTVADPASYGSGVRLASMDAAADPRLDVLAPLAIGVFGDLAAYRRRYRHEKA
                     FRGFLVDGGRLSAEVARALRAKGVSSTTRTGFTDPALLSALGLQPFVHHLAAAYVADEE
                     GAGHRYVATRVAP"
     misc_feature    9183..9193
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            complement(9190..10020)
                     /locus_tag="A4R25_RS16835"
     CDS             complement(9190..10020)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS16835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157539104.1"
                     /transl_table=11
                     /translation="MTIRLSSPGTPAEPVPAVVEERQIADAPFTGGGVPGASRHGGGRP
                     VLPTDQAVVVFESGGWRSYPTSGSDRAPWQQHGWGAAFDLVSDAMRNGSSPRTLSMPEV
                     LPDPSNMGAVVEHYPPVVSGARLSPAELFGAVGRCRRRYAAKGVGFHVAVVDAGELGPG
                     WYSPDGTLLIPRSRHDLGEELSSLLPVAYGRAEFDVGASVVVSVSVDAERDAADEYMEQ
                     LWIGGLAIGELEGYGSDLGWATRGNYAVLAGFHDVVGLDSGRQLAVGAVCWAGL"
     gene            complement(10001..11179)
                     /locus_tag="A4R25_RS16840"
     CDS             complement(10001..11179)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="A4R25_RS16840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_064447341.1"
                     /sec_met_domain="YcaO (E-value: 9e-33, bitscore: 109.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALTAAVVRDDWKCVRFTSPFDGLFGSVVEADDDVLGVAWDLDPA
                     RADERALGEAVERAALHEPALAPVRASANELGSKAIRLDDRATFSPEQCSQEPLLRPFA
                     WNAHSQNTWVTMQSPHGEVFVPADVERMRVHDSDPTRVKPMTSIGAACGVDWDTALTRA
                     LTEVVERHAVAAAVYSGRRAARVRPGDDRYSVHDIAEILGGAADVVVGLLPGSHFGLQV
                     ALAAIVGTRDGLPEVAFGSAAHADAADAIRSAAIEAVHIFHLGWRLLRRGDPEERPVGI
                     NTRALWWARHGRAHLGDYFVDQVAEAQGPTSGGRTWTEIGDAISAEGFRWAYSDITPAW
                     AAGAVVARAVVPALLHLQINPFPLLYAPRFPSEVEAFLRRSGGGVNNDHPFV"
     gene            complement(11190..12119)
                     /locus_tag="A4R25_RS16845"
     CDS             complement(11190..12119)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.5"
                     /locus_tag="A4R25_RS16845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitroreductase family protein"
                     /protein_id="WP_064447342.1"
                     /sec_met_domain="PF00881 (E-value: 1.2e-15, bitscore: 52.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTWSPLLVIRPDRDAAVLEDSQSAQSVRFDAAELARKLVSDAP
                     EVGARELSPSDDLDSISTDWVTNGWRPSLDYFNWSEQISESRREARYPARGSQAQPTRP
                     ATSTPQWNWAEEGTTAGTGGVSVGELLVRRRTARQFEPEPLSRETVAAIFRCFSALMAP
                     FEPSGSLAGVRMAAVVYAINGVDSGIWALDLAGERADQLTSGSFRQEMADLMCGMQAPM
                     TASATIVLIVDFPRRQEMFPYERALRELYVEVGRVAQKFIIAAESYDCGALITPATNDN
                     VLAELLGLSDDEAPVYTITFGRKTSRKG"
     gene            complement(12119..13273)
                     /locus_tag="A4R25_RS16850"
     CDS             complement(12119..13273)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013077.5"
                     /locus_tag="A4R25_RS16850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitroreductase family protein"
                     /protein_id="WP_124778785.1"
                     /transl_table=11
                     /translation="METLAEAAAENGTDARSATYRAHPLVRIEPAASDLWLISRDDRLN
                     GHKVPASAAGLLVAAFAPGTIYSLSEPIMAAIGSVRRAELIAEWLVAHEYLVRDDDAEA
                     IKTRRWLESWAENGWRAASRYHARTYGYPFEFYEADGNSAEDVRRMVAYNAQQPDVDRA
                     RPRLHDQEKVYALPDPAPELFPATASAATNLAVAAQPLDYDRLASLLSLLTRPIRQARM
                     PFAESANLLRKTSPSGGSRHPTEFSVVTHAVDGIDDGVYQVATVDGALDRMDHLDASSR
                     DLADLSGIADDNRPYALIFFNSYFARNRYRYREPRTFRTVHMDVGHLMGTAEYLSRANG
                     WAVRHAQHLDGKKVADALGTDHRVEATIAATLVHAADQPAESRD"
     misc_feature    complement(13237..13253)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    13307..13322
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.73"
                     /tool="antismash"
     gene            complement(13429..13599)
                     /locus_tag="A4R25_RS31165"
     CDS             complement(13429..13599)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS31165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157539106.1"
                     /transl_table=11
                     /translation="MMTTTAQEMSAQNAEVSLNETAEESSIDNIEGLFEEVDLFSTALI
                     QGGCTGGFTSL"
     misc_feature    13590..13604
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.28"
                     /tool="antismash"
     misc_feature    complement(13598..13610)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
     gene            complement(13815..14786)
                     /locus_tag="A4R25_RS16855"
     CDS             complement(13815..14786)
                     /codon_start=1
                     /gene_functions="regulatory (extras) StrR_like: StrR-like
                     pathway specfic regulators"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014273.5"
                     /locus_tag="A4R25_RS16855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="WP_082931048.1"
                     /transl_table=11
                     /translation="MIDANDPLQVVESWTEGSQQEAVSVPIRSLLPGQGPRRHGVDETH
                     VQLLAQSELQHPPILVQRSTMRVIDGMHRLQAALLRGADSIHALMLDDDDQMAFLRSVT
                     SNIKHGLPLTLADRRAAAERLLEMFAHWSDRSLGRATGLSAKTISTLRQRSGQPMPAER
                     TGRDGRVRPTDADAGRKAVVALLAERPDASLREIARLAGVSPNTVRTIRRKQNDGAAGS
                     PSPARALSAVKEPPGAPEPSRDVTALALENLAKDPSVRYTEAGRTLLRMLHQQLSLVSD
                     HDIINALPPHCLPLVARLSRGLSQQWEQLSARAAIRVQTEVG"
     misc_feature    14769..14783
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     misc_feature    14890..14904
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.94"
                     /tool="antismash"
     misc_feature    15036..15051
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.76"
                     /tool="antismash"
     gene            complement(15312..16964)
                     /locus_tag="A4R25_RS16860"
     CDS             complement(15312..16964)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (22-297). E-value:
                     4.1e-20. Score: 63.9. Matches aSDomain:
                     nrpspksdomains_A4R25_RS16860_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="A4R25_RS16860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_157539108.1"
                     /sec_met_domain="Condensation (E-value: 3.3e-16, bitscore:
                     53.9, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLRDGEKLEIRFRAPSGRTADLTWGQQRMAQLMADLQPNNASLN
                     LKFAHRIKPGLKADEVASAIRGMVEACESARTLFEPDAPSAQQRVTTEGVLHVAVITAV
                     TATFTSALESAAELAGTPFGADDLPVRVGILTDRSGPAFVLLAINHLASDYLGAHWMTW
                     HLRHVLQADFSDGEPSAIHPVDVSHWESSEAGRREGARALLRHERSLARMPQSMLPRLP
                     VEPLHPRYRYVVMQTSAGAWCLSHLAKRHGVSETAVGHAALSLVLAHVSGLSRAHLQVC
                     VSNRAGRDTAAVVGCLTQDVPTCVAIDDADFDALLRRSAGAIHHATLTGRFPHRGLMEV
                     RERVEKRRGFPLDLSYWLNSRLFVPLPAEAPNAARIREEAARTSVRWLGGDQCSTSTLF
                     CYLDRRDDILEVLMLVDTAYVAPAEAEQWLRAFESILVTAVLRPELSADALVAETGVVS
                     FRATDDWVKIDHSWIHLPTTAARLHAALPGMTLRLAIETPGGEASLVAMVASPRSGRET
                     SAPSDTVVVEALRGCRVGMRPHRFVSRAGDVQD"
     aSDomain        complement(16074..16898)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS16860_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="4.10E-20"
                     /label="A4R25_RS16860_Condensation_LCL.1"
                     /locus_tag="A4R25_RS16860"
                     /protein_end="297"
                     /protein_start="22"
                     /score="63.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: NHLASDY"
                     /tool="antismash"
                     /translation="LTWGQQRMAQLMADLQPNNASLNLKFAHRIKPGLKADEVASAIRG
                     MVEACESARTLFEPDAPSAQQRVTTEGVLHVAVITAVTATFTSALESAAELAGTPFGAD
                     DLPVRVGILTDRSGPAFVLLAINHLASDYLGAHWMTWHLRHVLQADFSDGEPSAIHPVD
                     VSHWESSEAGRREGARALLRHERSLARMPQSMLPRLPVEPLHPRYRYVVMQTSAGAWCL
                     SHLAKRHGVSETAVGHAALSLVLAHVSGLSRAHLQVCVSNRAGRDTAAVVGCL"
     misc_feature    complement(16924..16938)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.94"
                     /tool="antismash"
     misc_feature    16925..16936
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.91"
                     /tool="antismash"
     gene            17040..18128
                     /locus_tag="A4R25_RS16865"
     CDS             17040..18128
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020521360.1"
                     /locus_tag="A4R25_RS16865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_231915555.1"
                     /transl_table=11
                     /translation="MRGKVVGAAMEMVHARPVTLIQVAGLRKVFRKPEKAPGLRGSLRH
                     LLQRRFSEHVAVDGIDLSVAQGEAVAYVGPNGAGKSTTVKMLSGILVPTAGQVLVDGLV
                     PYRARVENARRVGVVFGQRTQLWWDLPVRDSLELLRDMHGLGAARYRETLARLDDVLGL
                     ADLLPVVARKLSLGQRMRADLAAALLHEPRIVYLDEPTIGLDIAVKDRVRSFVRRLVAD
                     GTTVMLTTHDLADIEDICRRIVIIDAGRVVYDGDLQSVKDTHVRERSMSFELAAGLPGV
                     DRIAARLPGAQVRAGSDDRELTVTFDRMTLGAREVLAAVLAEAEIVDMHIDEPAIETVV
                     RKVYAGQLRPEPGGGVDRETVS"
     misc_feature    complement(17077..17090)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     gene            18125..18967
                     /locus_tag="A4R25_RS16870"
     CDS             18125..18967
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007071468.1"
                     /locus_tag="A4R25_RS16870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_082931050.1"
                     /transl_table=11
                     /translation="MTFVTAGAVPLPADTRSRRIRAYRSMARMALKSLLAYQTSFLFGM
                     LASAFGVLSMLYLWRSALAAGPRQGFDWPQMKAYLLVAFVVGSLVSSYTDYRMANRIQQ
                     GDVAMDLVRPVDYQWSRLAESVGFAVYEAGTAIVVVLAAAAIFGGMSPPDRDTLPLFIL
                     SALLVLPLRFGIVYLSGLLVFWTQNYVGVQAARIALITLFSGALVPLAFLPEWMRVIAT
                     YLPFVGMASTPALLYTGSLDGSDATTAVLVQAAWAVALWWLARLMWSAAARKLTVHGG"
     gene            18957..19760
                     /locus_tag="A4R25_RS16875"
     CDS             18957..19760
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020510309.1"
                     /locus_tag="A4R25_RS16875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_064447346.1"
                     /transl_table=11
                     /translation="MVAEARRALWLYRRLLGAQVRATLQYEADFWIMSLSAVLVQAVGV
                     VFLWAIFRSIPEINGWQFWEVVLIYALVVVAEGLSVLVAQGAWTLAVTVNFGQLDAMLL
                     RPYPPVLQVLSSAVGMNGLGNLVLGTGLLIAAVRHVDVSWNVGRVALGLLLVVAAAGVK
                     IGLNLLTNCAAFWLRSPYSMFAFSMHSFGELARFPVTIYGLGVRITLTVVLPYAFMSFF
                     PAAAVLAHGPARWLGLLTPVVAIYCLWIGTTVFRYGLSRYESSGH"
     gene            19873..20757
                     /locus_tag="A4R25_RS16880"
     CDS             19873..20757
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS16880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_104114715.1"
                     /transl_table=11
                     /translation="MWISRAEALDTLRCTPEELAQLVAAGLVEEDGRHDYCDVWNVGLL
                     SGTGRSSPERIMIFFARMLKSYGADWVSARAYEIVGWAQCPRAEHCPSSEWSAPVLPDV
                     QWQHEEIQAGRAEWRGRVELTGNTATVRDPRVREVWDDLLRRYRFHFTPMTLSSDVAGT
                     RHRGVGDCDSLCQVLMSELLDRGVAAEQESGYIFGGARLGLHSWVRLVDTDGEVKILDP
                     AMALLSDLFFTPEYKAFCCGSGSNRVLRRASREGMFAAHPCVTEDGRIFYEFTLRSIRP
                     GRAPGPRCSEGAG"
     gene            20754..22091
                     /locus_tag="A4R25_RS16885"
     CDS             20754..22091
                     /NRPS_PKS="Domain: AMP-binding (129-352). E-value: 6.3e-18.
                     Score: 56.4. Matches aSDomain:
                     nrpspksdomains_A4R25_RS16885_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="A4R25_RS16885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_082931051.1"
                     /sec_met_domain="AMP-binding (E-value: 5.7e-13, bitscore:
                     42.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGPEVEVTDHDGTRGGAGAAAVGRPVVIDGRSPPLTSHDLHADV
                     LGLRRRVPRGATVALVGQSSRLVASAIVALEGWAARVEFVGDLSPTVGSAEAVVLREAG
                     ADAPAAAYASHGELSAGDASTDVRTLWRVFSSGTTGTPTPTDHSLDSLTRRIRPVRPAR
                     NPGDREQRRWGLLFSPTRMAGIQVVLQAIHGDTLVDAHHAAGLDERLQLFAGAGIDALS
                     ATPTMWRMILRSRACDDLRLQQITLGGEIATQSLINALRRRFDARVTHVYASTEAGAAF
                     SVSDGREGFPRHFLEPAPGRVALEIRDGVLFVRAPGSSTAQPDGFVCTGDLVEPRGDRV
                     YFVGRKSQTVNVGGDKVSPERVEELIRRHPAVHDAVVTPRRSPITGWILTARVVPSPLG
                     SGLDPDELQSALRSFVADHLPRSHTPASITAVTEFFLSPTGKVSRA"
     aSDomain        21141..21809
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS16885_AMP-binding.1"
                     /evalue="6.30E-18"
                     /label="A4R25_RS16885_AMP-binding.1"
                     /locus_tag="A4R25_RS16885"
                     /protein_end="352"
                     /protein_start="129"
                     /score="56.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LWRVFSSGTTGTPTPTDHSLDSLTRRIRPVRPARNPGDREQRRWG
                     LLFSPTRMAGIQVVLQAIHGDTLVDAHHAAGLDERLQLFAGAGIDALSATPTMWRMILR
                     SRACDDLRLQQITLGGEIATQSLINALRRRFDARVTHVYASTEAGAAFSVSDGREGFPR
                     HFLEPAPGRVALEIRDGVLFVRAPGSSTAQPDGFVCTGDLVEPRGDRVYFVGRKSQTVN
                     V"
ORIGIN
        1 tctgcacgcg gatatgtcga cgagcggatt cgcgcggagc agaacgacgt ctgccaccgt
       61 gccgtcgcac agggagccca gatccggacg acggagggcc tcggctgccc tgcacgtcgc
      121 cgccgcgagc gcttcgtgcg gggaggcgcc ccagtcaacc atggcctcca gctcggacgg
      181 cagggagtcg aaacccacac cggcggctcc ggcgtccgtc cccgcgatga gggtgacgcc
      241 ggccgccaga gctcgctcga agctgcgtcg tgcctccggg agttgactga cggccatctc
      301 caccagactt ttgcctccct gccggatcca gagctgcgga cgcctcacta tcgattggag
      361 cgctacagcg gtggagcaga gggcggtgcc ttgtttcgac atcgcaccgg cagcggcctc
      421 cgatatcgcg aagccgtgct ccaaggtgtc gcagccggct tccacggccg cgtcgatcga
      481 acgctccgag aagttcgcgt gtacggctac ggggatgtcc agccaacggg cctcggcgac
      541 cgcctccctc agttcctccg gccggagttc catccggcgc gccgcgctgc gcatcaccag
      601 cttgatcaca tccgcgccgt cggcggcgtt tcgacgcacg agcgcgccga tggatccggc
      661 tccttcggac tcgacaccga gccagcttcc gtgcccgccg actgcggtga tgaccggacc
      721 ggcgacgaac ggcctggccc cgacgaacaa gtcccgggcc caggcgttgc ggatggagta
      781 cccgaggtca cgcggagcac ccaggtcgcg gaccgtcgtg atcccactgc gcagcgcggt
      841 cgccagattc gcgacagccg tcagcgtcat ggtggtggcc gagatgtccg accagctcga
      901 cgcggtccgg ccatgaggat cgctggtcgc gtggacgtgc atgtcgatga gcccgggaac
      961 ggcgaacaaa ccggtgccgt cgaggtgtgg gaggtcggca tctgcggtgg tgcgtgtgct
     1021 gactgaaccg gagatgatcg acaacgagcc gagggtggtg gtgccggaat ccggatcgat
     1081 gacggtgcag ccggcaatgg tgaaatccgc ggtcggcgtg gccgtcacga cgatccttcg
     1141 gagacgcggg cagcgcgcac tgcctccccg tgccatcccc gcgcgcgcga cagattcacg
     1201 gccaagtcca ccagttcgtc cgcctcccgg ccgcggccgg ccatgtggtg ccagcgcgcc
     1261 agctctgcca gcgcgaggat ccgggcgccc aggtaggcgt gccggccggt gcccgtatcc
     1321 acaggcgacg tcatggcgtc ggtcgcctga cggacggcag cgagcagcca tgactccggg
     1381 tctggagcga tgcccaccag cgcctcgagc gcgttcgcct cgtcctcggg cacctcgcgg
     1441 gaagcggcta gggcgattcc cggcgcgagg taggcgtaga ccggctcacg gtgggcgccg
     1501 gtaagccgga catggtcgaa gtatcgtcct gtcgcttgaa gggcggcgcg ggccgagtcg
     1561 tgacgtgcgg cagcgaacgc ctggtgcgac aggatgaaac cgaactggcg gaacgccttc
     1621 gaggcgagtt cggtgtcgcc gccgtcgcga acctgacgga ggagatctgt cgcgtgctcg
     1681 tacgaggacc aggcgcccgc gacgtcaccg gatgccaact ggacatatcc catgttgtgc
     1741 cacgactggg cggcagccat cagatctccg gtgccgaggc gcacctggat cgcctcgcgg
     1801 aagtcgttca cgggcggatc gtcgtcgaag tggtgaaacc gccatacgcc gatggagtgg
     1861 caacattcgg cgagagccga cagggcctcc gaatcacgga gaagatgtct cgctgtctcc
     1921 gccagcttga ttgcctccgc ccctctgccc tgcttctcca ccgcccacgc cgtgttgagc
     1981 agtgctcgcc cctccccggc gacattcgcg gaagcggcgc attccgaagc ggtccgggaa
     2041 aaccgttcct ctgcctcgac gtagcgagcg ggatcgtcca gacctagctg agctggcgtg
     2101 aacaagggcg gtcacctcga cgtcgtcgac tgattgctga gattgacgcc gatcgtagcg
     2161 ttcgggtggc ttgttcacga gggtgtgcga cctgtcggca gttgatgcgc gccgtgcctg
     2221 tgaggcacgt tcaccaccca ctttcgcgtc cgtcatcctc cttgccgccg ccatcggccg
     2281 aacggcgcga tgggctacac tggcccggaa aggcgtcgat agggacgagt accactgcac
     2341 gcagccagca gagacccggg gatggtggaa gcccgggggt gtgcgcagcg ggaagatcac
     2401 cctggagccg tcggaagaaa ggcgtcacgc cgagtagacc cgaccacaac ttaacgagag
     2461 ggccgcgcgc tgtggccaag gagggtggta ccgcggggcc cgggcctcgt ccctccaccg
     2521 aagttcggta accgcttcgt tggaggatcc atgtaccgcg ctgtgcccgc gcaggcgagc
     2581 tttcccgata tcgatcacgg catcctcaaa ttctggagtg atcgtaaggt cttcgccctc
     2641 agcctggaaa gatcgcaggg gcggccggaa tgggtcttct acgaggggcc cccaacggcg
     2701 aacggtatgc caggggcgca ccacatcgaa gccagagtgt tcaaggacgt ctttccccgg
     2761 tacaagacga tgaagggctt ccatgtcgcg cggaaggccg gctgggactg ccacggactt
     2821 ccggtggaac tggctgtcga gcgcgaactc ggcttttccg gtaagcgcga catcgaggcc
     2881 ttcggtatcg cggagttcaa cgcccggtgc cgcgagtcgg tgacccggca taccgacgag
     2941 ttcgcccggc tgaccgaacg catgggctac tgggtcgata tggacgacgc ctaccggacg
     3001 atggacccgg aatacatcga gtcggtgtgg tggtcgctga agcagatctt cgaaaaaggg
     3061 ctgctcgtcg aggacttccg cgtggcgccc tggtgtcctc gttgcgggac ggggctgtcc
     3121 gatcacgagc tcgcccaggg gtacgaggtg gtcaccgacc cgtcggtgtt cgtgcggttc
     3181 ccactcacct cgggccccct ggcgggccag gcttccctgc tcgtgtggac cacgacccca
     3241 tggacgctgg tctccaacgt cgcggtcgcg gtcaatcccg acgtcaccta cgtcgtaatg
     3301 accgacggcc aggagcagct cgttgtcgcg gaggcgctgg cgggcagcgc actcggtgag
     3361 ggatggaccg tcgtcggcga ctccttcagt ggcaaggaca tggaacgctg gacctaccgg
     3421 cggccattcg acctggtcca ggtcgaggac gcgaacttcg tcatcctcgg gacgtacgtg
     3481 acgaccgagg acggcaccgg cctggtgcac caggcgccgg cattcggcgc tgacgacctc
     3541 gccgcgtgcc gtgcgtatgg tcttccgatg gtcaaccccg tccgtccgga cggcacgttc
     3601 cagtccgacc tcgcgctcgt cggcggcacg ttcttcaaga gtgccgacgc ggtcctggtg
     3661 gcggatctcg ccgagcgtgg actgctcttc cgcgaggagg cgtacgagca cagctacccg
     3721 cactgctggc gttgtcacac ggcgctgttg tactacgcgc agccgtcctg gtacatccgc
     3781 accacggcca tccgggaagc gctgctgcgc gagaacgagg cgacgacctg gcagccgcag
     3841 aacatcaagt acggccgcta cggggactgg ctgaacaaca acgtcgactg ggcgttgtcc
     3901 cgcagtcggt actggggcac gccgttgcct atctggcgct gcccggacaa ccacctgacc
     3961 tgcgtcggct cgctggccga gctgagcgag ctggccggga ccgacctgtc cgagctggat
     4021 ccccaccgtc cctatatcga tgacgtcacc ttcgactgcc gatgcggcgc caccgcgcgc
     4081 cgggtgcccg aagtcatcga cgcgtggtac gactcgggct cgatgccttt cgcgcaattc
     4141 gggtatccgc acaagaacgt cgaactcttc gagaagcggt acccggcgaa cttcatctcg
     4201 gaggcgatcg accagaccag gggatggttc tacaccctca tggcggtggg caccctcatc
     4261 ttcgacaagt cggcctacga aacggtcgtc tgcctgggcc acatcctcgc cgaggacggc
     4321 cgcaagatgt cgaaacacct ggggaacatc ctcgaaccca tcccgctgat ggacgagcac
     4381 ggtgccgacg cggtgcgctg gttcatggcc gctgtcggtt ccccgtggtc agcccggcgc
     4441 gtcgggcaca acacgcttca ggaagtcgtc cgcaagactc ttctgaccta ctggaacacc
     4501 gtgtccttcg gggcgctgta cggccgtgcc gccggctggt cgccgtcggc ggcagatccc
     4561 gcgccccgta gccgcccgct gctggaccga tggctgttgt cggagctcaa cagcctggta
     4621 cgcgacgtgg acgccgcgat ggagcgcttc gacacccacg aggccggccg gctgctgtcc
     4681 acgttcatcg acgatctttc caactggtac gttcgccgca gccgccggcg tttctggcac
     4741 ggcgacccgg ccgccctggc cacgctccac gagacgttgt ccaccctgac gctcctcctc
     4801 gcgccgatca caccgtttgt gaccgagcgg gtgtggcagg acctggtggt tccggtcacg
     4861 cccggtgcgg cggagtccgt gcacctcgcc gcatacccca ccggtgacct gtccctgatc
     4921 gacccggaac tgtcggcgca gatgcttctc gtgcgtcggg tcgtcgaact cggccgctcc
     4981 gcccgcgccg actccggcat caggacgcgc cagccgctgt cccgcgcggt cgtgtccgcg
     5041 gcaggtttcg ccgacctgcc ggcggaactc ctcgccgaga tcgcgtcgga gctcaatgtc
     5101 gtctcggtgg cacccatcac ggccaccagc ggttcactcg tggacacgac ggtgaaggcg
     5161 aacttccgtc ccctgggcaa gaggttcggc aaggcggtcc aaggcgtcgc cgcggcgatt
     5221 atggcggccg agccgaccgc cctcgccaac gccctccgta cgagaggtga ggcgaccgtc
     5281 gacgtggacg gtgaggcggt ggtcgtcacg gtggacgagg tcgtcatcac cgagactcca
     5341 cgtgccggat gggcggtcgc caacgacgca ggtgcgacgg tggcgctgga tctggacatc
     5401 acgccggaac tccgcctcgc cgggatcgcg cgggacgtga tccgccagat ccaggaggcc
     5461 cgcaaggcca ccggcctgga ggtcgccgat cgcatcgaac tccgctacga ggcgaccgct
     5521 gacaccctga cggcgttgac ggagcatcag aagctggtgg ccgacgaggt gctcgcgacg
     5581 gacttcaccc tcgggcggcc gacgtgggca gacgcgacgt ccttcaccga cgagacgctc
     5641 ggcctgacgt tctggctgcg taaggcatga ggagcgccgg ggccacgagc acgccgcccg
     5701 ttcggccgtg cgtcgtggcc ccggcccttc gtatcggccg gcggcgggcc gagcggcggg
     5761 tcagcgaacc ccgtggacgt ccgtggccag aacactgaac cgcccggtgt ggaacaccag
     5821 tgcgtcggtg cggtcgccgt ggccgatgtc cagcaccgag ccgaggaata tggagtggtc
     5881 accgccctcg tacacggcgg cgagctcgca ctccacccag ccgaggttgc cctcgatgat
     5941 gggggagccg gtgtgctcgc cgggccggaa atcgacggta cggaactccc gctcgtcgcg
     6001 cggccggctg ggactggcga agtagcgcgc cagttcttcc tgtcctgcgg cgaggatcga
     6061 caccgcgaac atcccgttcg ccaggattgt gctgtgcatt gcggcggact gctttacgca
     6121 caccaacacc atcgccgggt cgagcgagac cgacgtgaac gcgttggcgg tcatgccgtg
     6181 cgggagttcc cgcccggacg tcaccaccgt gacgcccgtg gcgaacgcac ccatcaccgc
     6241 ccgcatgtcg acgtgacggt caccgccgca gcggtcgcgg gacacgggct tctgcttcgc
     6301 ggctgtcacc gttcacctct tccgtcagcc accggggccg tcagcacgtc gcgcatcatc
     6361 cacagcgctc ccttccccgt caggtgagtg gtcggcggca tgcgcgcacc ggcctcggct
     6421 cagtcgccgg agccggcatc gatcgccgac cgggtggaac tcctcgccac tatctgctcg
     6481 gcggtcgctc gtatcgtcag ccagccgacg ttcgcggggt cgtcgaagcc ggcgtcgggg
     6541 aaggttcctt ccagccgcgc caacagctcc actgcgagga gggagtctcc acccgccgcg
     6601 atgaaatcgt ggtcgacgtc caccgcatcc gtctccagca gttcccgcca gaatccgcta
     6661 actgtttcga gtacctcaga cgaatccacg tcgctctcct cagcgaagct ccgaaagcgt
     6721 gccctcgccg cgcgcaatcg aattctttaa atcgttcttc aggatcttgc cgttctcggt
     6781 cacgggcatc gatccgacag cgaacacgcg gcgcggtatc tgcttcggtg gcagacgctc
     6841 gagcaggtgc acgcgaatgt cgttcaggct cgtccggccc ggccggagca ccacgaccgc
     6901 ggcgacgtac tcacccagcc ggggatgcgg gagtccgagc acggccgcgg cctcgaccat
     6961 cgggtgcgag aggagggcga tctcgaccgg gcgtgccgag agcttctccc cgccgacgtt
     7021 gaggacgtca gagacgcggt cgctcagatg caggttgccc tcctcgtcga gatgaccgat
     7081 gtctccggtc gccgtccagc cgtccggaag gaaggttttc gagggcactg agtcgtgcag
     7141 gtaggagcgg cgtccgcgga accgcggaca ggacatctcc acgcggccgt ggacgcccgg
     7201 gccgacgacg agccccgtct ccaggctcct gatgcggatc cgggtgcctc gtgccggtct
     7261 cccgacgaca tcgggatccg cgcccgctga cggcatctcc accatcgcgg gccaagcctc
     7321 ggtggttccg tacgcgttga ccacccgaac ggacggcagc atccggcgga ttcgttccac
     7381 atgagccgga ttcagcggcg ccgaaccgca gtggattacc tccagagacg cgagcatctc
     7441 acgttgcgac gaggtgagcg tcgtgagatg tgccagcatg gcaggcgtca ggaacaacag
     7501 ggtgacctga cagtcggcga ccgccttgca cacgtcattg gtgttgaact ccggcagcgc
     7561 cgcgaccgcc ctggtgatgg gatgcgtgag cccgggcccg tcgatgccct ggaacggggc
     7621 gtacaacatc atgagcgcgg ccgccgtacc gatcgggaag gcgtgcagga tcggtgggcc
     7681 gatgccgccg tgagcggacg gcgggcgggc gtagacctcc gtgaagagcg cgtgcggcgt
     7741 cacgaccgcc ttgggcaggc cggtcgtgcc ggacgtgtag agaatgtcgg ccgtctgctc
     7801 ggggcgggtc gtcgccggcg ggggaacccg gtccccacag cgcggaggct cgaccggaag
     7861 aacctgatac ggatcgccgc ccgggccgtt ccccaccggc gacgagtccg cagcgatcca
     7921 tgcggagatg ccggcgtcct gggtgatgaa gtcgcggacg gacaccggag ctcccgccga
     7981 gacggtgaca gtgaccgcgc ccagccgttg caccgcgaag taggcgacgc acagatcgat
     8041 ccagtgcctg cggtcgaaca gcagaccgac acgcatgcca ctggtgatcc ctgcctcgga
     8101 aaggcgcgcg gccagcgcca ccgagtcgtg caaccactcc gcgaaggtga gaccacgcac
     8161 gaacggttcg accagcgcga ggcggtcggg aacctccccg gctacgcgct cgagcagccc
     8221 gaacgtcccc gtgcaacggt ccgtcgcgcc acctgcccct ctcgtcgtca cggtgccacc
     8281 cgggtcgcga cgtatcggtg gccggcgccc tcctcgtccg cgacgtaggc ggccgcgagg
     8341 tgatggacga acggctggag gccgagcgct gacagaagag cggggtcggt gaagcccgtg
     8401 cgggtggtcg agctgacgcc cttcgcccga agagcgcgag cgacctccgc gctcagccgt
     8461 ccgccgtcga cgaggaagcc gcggaacgcc ttttcgtggc gatagcgtct ccggtaggcg
     8521 gcgagatcgc cgaagacccc gatggcgagg ggagccagga cgtcaagtcg cggatccgcc
     8581 gcggcgtcca tggacgccag gcggactcct gaaccgtacg aggcggggtc ggccacagtg
     8641 accaggacgc gaccgtccac gcgtgacacg atcagtagcc cgtgggccgc tccgtagctg
     8701 tagagcagct cggccgggtg caccgcctcg cgcaaccgcc ggcgattggc gcgcacccgg
     8761 gtgagagcgg tccagaccac cgccgcccac ggttcgggaa tctgctcccg gcgaccctgg
     8821 gggacagccg gctcgcgcag ggcatcgagg tcgtcttgcg agaacagccg cagcgccgat
     8881 gcccggaggc caccagtcga atccgctccg tcgcgaaaat gatcgattcc gctccaggcg
     8941 tggtagcggc gcaccggccc ccacgacgtg ccgtcggcac cttcgcgttc gaccaggaga
     9001 ccgaggcgga tcaactgctg tacggccggg tcctcgaact cctcggcgac gacctggtgc
     9061 agaagccgct cgacgcggcc cgcgtccagg cgccacgacc ggcccagcgc cggtgcgctg
     9121 atccggatgg tgtcggagcc ctcgttctcc atggtcgttc ccgcagccca cgtgtacgcg
     9181 gctcccatgt cacagccctg cccagcagac agcaccgaca gccaactgtc tgccggagtc
     9241 cagcccgacg acgtcatgga acccggcgag caccgcatag ttgccgcgtg tcgcccatcc
     9301 caggtccgag ccgtaccctt cgagctcgcc tatcgcgagt cctccgatcc agagttgctc
     9361 catgtactcg tcggcagcgt cccgctcggc gtcgacggac actgatacga ctaccgatgc
     9421 gccgacgtcg aactccgccc ggccgtacgc gaccggaagg agggaggaca actcctcgcc
     9481 gaggtcgtgc cggcttctcg ggatcagcag ggtcccgtcc gggctgtacc acccgggacc
     9541 cagttcgccg gcgtcgacaa ccgcgacgtg gaacccgacc cccttcgccg cataccgccg
     9601 gcggcaccga cccaccgcac cgaagagttc tgcgggcgac agacgtgccc cgctcacgac
     9661 aggcgggtag tgctcgacca ccgctcccat gttcgacggg tcgggaagca cctcgggcat
     9721 cgacagcgtg cgcggcgacg agccgttcct catcgcgtcg ctgacgaggt cgaaggcggc
     9781 gccccatccg tgctgctgcc acggtgcccg atcactgccg gacgtgggat atgaccgcca
     9841 cccacccgac tcgaagacga cgacggcctg atcggtcggc agcaccggcc ggcctccgcc
     9901 atgccgcgac gcgccaggca ccccgccgcc ggtgaacggc gcgtcggcga tctggcgctc
     9961 ctcgacgacc gcgggcaccg gttccgccgg agttcctgga ctagacaaac ggatggtcat
    10021 tgttcacccc gccacccgag cgacggagga acgcctctac ctcggacggg aagcgcggag
    10081 cgtaaagcag cgggaacgga ttgatctgga gatggagcag ggcagggacc accgcgcgag
    10141 cgaccacggc gccggcggcc catgccgggg tgatgtcgct gtacgcccag cggaacccct
    10201 ctgcggagat ggcatcgccg atctcggtcc aggtacgtcc gcccgaggtc gggccctggg
    10261 cttcagccac ctggtcgacg aagtagtcgc ccaggtgggc gcgcccgtgc ctcgcccacc
    10321 acagcgcccg ggtgttgatg cccaccggcc gctcctcggg gtctccccgg cggagcagac
    10381 gccagccgag gtgaaagatg tgcaccgctt cgatcgccgc tgagcggatc gcatccgccg
    10441 cgtccgcatg ggcggccgac ccgaaggcca cctccggcag tccgtcgcgg gtgccgacga
    10501 tggcggccag cgcgacctgc aatccgaaat ggctgccggg cagcagcccg acgaccacgt
    10561 cagccgcacc gccgagaatt tccgcgatgt cgtgaacgga gtaccggtcg tcgccgggac
    10621 ggactcgggc cgcgcggcgc ccggagtaga cggccgccgc aacggcgtgc cgttccacga
    10681 cctcagtgag cgcgcgggtg agggccgtgt cccagtcgac cccgcaggcg gcgccgatcg
    10741 aggtcatcgg tttgacgcgg gtcggatccg agtcgtggac ccgcatccgc tcgacgtcgg
    10801 cgggtacgaa cacctcgccg tgcggagact gcatcgtcac ccaggtgttc tgggagtgcg
    10861 cgttccatgc gaacgggcgg agcagcggct cttgcgagca ctgttccggg ctgaaggtcg
    10921 cccggtcgtc gagacggatg gccttcgagc cgagctcgtt cgcggacgca cgcacaggtg
    10981 cgagggctgg ctcgtgcagc gcggcgcgct cgacagcctc acccagtgct ctctcgtccg
    11041 cccgtgcggg gtcaagatcc cacgcgacgc cgagcacgtc gtcgtccgcc tcgacgacag
    11101 agccgaagag cccgtcgaaa ggactcgtga atcggacgca tttccaatca tcgcggacga
    11161 ccgcagcggt gagtgccatt ttttgtgggt cagcctttcc tgctggtctt ccgaccgaag
    11221 gtgatggtgt agaccggtgc ctcgtcatcc gagagcccga gcaactccgc cagcacgttg
    11281 tcatttgtcg ccggggtgat cagcgcgccg cagtcgtacg actccgccgc gatgatgaat
    11341 ttctgcgcga ctcgacctac ctcgacgtac agttcgcgca aggccctctc gtaggggaac
    11401 atttcctggc ggcgggggaa gtcgacgatc agcacgatcg tggcgcttgc cgtcatgggt
    11461 gcctgcatgc cgcacatcag atcggccatc tcctggcgga agctgccgga ggtcagctga
    11521 tcggctcgct cgccggcgag gtcgagagcc cagatgcccg aatcgacgcc gttgatcgcg
    11581 tacacgacgg cggccatacg cacgcctgcc agcgagccgg acggctcgaa gggtgccatg
    11641 agcgcggaga agcagcggaa gatggcggcg acggtctccc gcgacaaggg ctccggctcg
    11701 aactggcggg ccgtgcgtcg tcgtaccagc agttcaccga cgctgacccc gccggtgccg
    11761 gccgtagtgc cttcttctgc ccagttccac tgcggcgtcg acgtcgctgg acgcgtcggc
    11821 tgagcctgac tgccgcgtgc cggataccgg gcctcccgcc tgctctccga gatctgctcg
    11881 gaccagttga agtagtcgag gctcggacgc cacccgttcg tgacccaatc ggtcgagatc
    11941 gaatcgaggt cgtccgacgg agacagttcg cgggccccga cctcgggggc gtccgacacg
    12001 agtttccggg cgagttcggc ggcgtcgaag cggaccgact gcgccgactg ggagtcttcg
    12061 agaacggcgg cgtcacggtc gggtcggatg acgaggagtg gcgaccatgt cgtggacatc
    12121 aatcccggct ttctgcaggc tgatcggctg cgtgtacgag agtcgctgcg attgtcgcct
    12181 cgacgcggtg gtcggtgccg agcgcgtccg cgaccttttt gccgtcgagg tgctgggcat
    12241 gccggaccgc ccaaccgttc gcgcggctca ggtactcggc agtacccatg aggtggccca
    12301 catccatgtg caccgtccgg aaggtccttg gttcccggta gcggtagcgg ttccgggcga
    12361 aataggagtt gaagaatatg agtgcgtagg ggcggttgtc gtcggcgata cccgacaggt
    12421 ccgccaggtc gcgtgacgag gcgtcgaggt gatccatgcg gtccagcgcg ccgtcgacgg
    12481 tcgcgacttg gtagacaccg tcgtcgatcc cgtcgacggc atgcgtgacg acggagaact
    12541 ccgtcggatg acgactaccg ccggaagggc tcgtcttccg cagcaggttg gccgattccg
    12601 cgaacggcat cctggcctga cgaatcggtc gggtcagcag ggagagcagc gacgcaaggc
    12661 ggtcgtagtc cagcggctgc gccgctaccg caaggttcgt cgccgccgaa gcggtcgcgg
    12721 ggaacaactc cggggcgggg tccggcagtg cgtacacctt ctcctggtcg tgcagccggg
    12781 gccgggcccg atcgacgtcg ggctgctgcg cgttgtacgc gaccatccgg cgtacgtcct
    12841 ccgcggagtt gccgtcagcc tcgtagaact cgaaggggta tccgtaagta cgcgcgtgat
    12901 agcgggaggc ggcccgccat ccattctcgg cccacgattc cagccaccgc cgcgtcttga
    12961 tcgcctcggc gtcgtcatcg cgcaccaggt actcgtgggc gaccagccac tcggcgatca
    13021 gctcggccct gcgcacggag ccgatcgccg ccatgatcgg ctccgacagg gaatagatgg
    13081 ttcccggagc gaaggcggca acgagcagac ccgcagccga cgcgggaacc ttgtgtccgt
    13141 tcaacctgtc gtctcggctg atgagccaca ggtcactggc cgccggctcg atgcgcacaa
    13201 gagggtgcgc gcgatacgtt gcggaacggg cgtcggtgcc gttttctgcg gcagcctcag
    13261 ctagcgtctc caaagcaggg tcctatctct tgtacgctcc gaccggttga ctttctggac
    13321 aacctgaatg attgacatcc tgtcggcgtt cgcggatacg gctgcccgat gacaggaaag
    13381 cgcgtgctaa ccggccgaaa gacggccggt tagcacgcga cagttggatc acagggacgt
    13441 gaagccgccg gtgcagccgc cctggatgag ggccgtcgag aagaggtcga cctcctcgaa
    13501 gagaccctcg atgttgtcga tggacgattc ctcggcggtc tcgttgaggg agacctctgc
    13561 gttttgcgcg gacatttcct gcgcggtggt tgtcatcatg caaaaagcat tacagggcta
    13621 tttagctatg tcaatgagtg cagctgcggc gggcgcagtc ctggctcttc cggacatatt
    13681 tgcgcctcga cgtcgacgcg acgagcgagc gtccggccac cgcccggcgc cgggcggtgg
    13741 ccgaagaagt gccaaggctg aggtgcggtg gggcggacga tcgcggcgtg tggacggtcg
    13801 gcgggtttgg ccgctcaacc cacctcggtc tggacgcgga tcgccgctcg cgcggagagt
    13861 tgctcccact gctgcgacag tccgcgactg aggcgggcca ccagcgggag gcagtgcggt
    13921 ggaagagcgt tgatgatgtc gtggtcggag accaggctga gttgttgatg cagcatgcgc
    13981 agcagggtgc gcccggcctc ggtgtagcgc acggacggat ccttggcgag gttctccagc
    14041 gccaacgcgg tgacgtcccg gctcggctcg ggcgcgccgg gcggctcctt gaccgcggac
    14101 agtgcccgtg ccggcgacgg tgaacccgcc gcaccgtcgt tctgtttgcg gcgtatggtg
    14161 cggaccgtgt tcggtgagac gccggccaac cgggcgattt cccgcagcga agcatcaggt
    14221 cgttcggcca ggagcgcgac gacagctttc cggccggcgt cggcgtctgt cggccggacc
    14281 cgtccgtccc ggccggtccg ctcggccggc atcggctggc cgctgcgttg cctcaatgtg
    14341 ctgatcgtct tggccgacag cccggtggcg cggccgagtg accggtccga ccaatgcgcg
    14401 aacatctcca gcagacgttc ggccgccgcc cggcggtcgg ccagggtcag cggcaggccg
    14461 tgcttgatgt tgctcgtgac gctgcgcagg aaggccatct ggtcgtcgtc gtcgagcatc
    14521 agcgcgtgaa tcgagtccgc accacggagc agtgccgcct gcagacgatg catcccgtcg
    14581 atgacgcgca tggtgctgcg ctgcaccagg atcggcgggt gctggagttc ggactgggcc
    14641 aacagctgta cgtgcgtctc gtcgaccccg tgccggcggg ggccctgacc gggcaggagc
    14701 gaccggatcg gtaccgatac ggcctcctgc tggcttcctt cggtccagct ctccacaacc
    14761 tgcagcggat cgttggcgtc gatcaacctg tcctccccgt gaacagctgc tgatgcctcg
    14821 ctgaccggct cttcttgggc tcagtcgtcg cctctcgtga gtggaaccgg tccgataaat
    14881 cagagaacaa cttgtcggaa atttcgggct ccggtgatgc cgctggtagt gggccgatcc
    14941 tgagtactct ggcggcccgc ggcatgtgca actgtagctt ctgaccgctt gcacaggtgc
    15001 cccgcggcac ccggaaattt ctcggattca atgcgtcgac gctcttttcc ctgcttggcg
    15061 gtcggtctcg ctgtggtgta gggcaggggg tcacctacgc ggtcgcgggt ggcatgccgt
    15121 gcgacccggt gtcgcgtgcg cagctgcgga accgcatcac tgccgcgccg ggattctcgg
    15181 tgcctttccg taacttccgg gagtgagagg gccatggcga cctgggcgcc gccgaccggt
    15241 tcgagagcga ctgcggcctg ctgtcctcgc gtgcccgggc acccgggccg cgaggcggtc
    15301 cacgtcgccg atcagtcctg tacatcccct gccctcgaga cgaaccggtg cgggcgcatg
    15361 ccgacccggc agccacgaag cgcctcgacg acaacggtgt cggaaggagc gctggtctcg
    15421 cggccgctcc gaggactggc caccatcgcc accagggaag cctcaccacc gggagtctca
    15481 atcgcaagtc gtagggtcat gcccggaagc gccgcatgca ggcgtgccgc cgtggtgggt
    15541 aggtggatcc agctgtggtc gatcttgacc cagtcgtccg tcgcgcggaa cgacacgacg
    15601 ccggtctccg cgacgagagc gtccgcgctg agctccggtc gcaggaccgc ggtgacgaga
    15661 atcgactcga acgcacgcaa ccactgctcc gcctcggcgg gagcgacata ggcggtgtcg
    15721 acgagcatca gcacttcgag tatgtcgtcg cggcggtcca ggtagcagaa gagggtgctc
    15781 gtgctgcact ggtcgccgcc cagccaccgg acggaggtcc tggccgcttc ctcccgtatc
    15841 cgcgcggcgt tcggtgcctc cgcggggagc ggcacgaaca gtcggctgtt gagccagtag
    15901 gagagatcca gcgggaagcc gcgtcgcttc tcgacgcgct cgcgcacctc catcaggcct
    15961 cggtgcggga agcgcccggt cagtgtcgcg tggtggatgg cgccggcgga tcgccgcagc
    16021 agtgcgtcga agtcggcgtc gtcgatcgcc acgcaggtgg gaacgtcctg ggtgaggcaa
    16081 cccaccacgg cagccgtgtc ccgaccggcc cggttgctga cgcacacctg gaggtgagcc
    16141 cggctcagcc cgctgacgtg ggccagcacg agggagaggg ccgcgtggcc gaccgccgtc
    16201 tcgctgaccc cgtgccgctt ggccaggtga ctcaggcacc acgcgccggc tgacgtctgc
    16261 atcaccacgt accgatagcg gggatgcaac ggctcgaccg ggagccgggg cagcatgctc
    16321 tgaggcatgc gtgcaaggct ccgttcgtgc cggagcagcg cacgggcccc ttcccgccgg
    16381 ccggcctcac tgctctccca gtggctgaca tcgacggggt ggatcgccga cggctcgccg
    16441 tcggagaagt cagcctggag gacgtggcgg aggtgccagg tcatccagtg agcgccgagg
    16501 tagtccgacg cgagatggtt gatggccagc aggacgaagg ccgggccact ccgatcggtc
    16561 aggatgccca cgcgaacggg gaggtcgtcg gccccgaacg gggtgcccgc cagctcggct
    16621 gccgattcga gagccgatgt gaaggtggct gtcacggcgg tgatcaccgc gacgtgcagg
    16681 actccctcgg ttgtgaccct ttgctgtgcg gagggcgcgt ccggctcgaa cagggttcgc
    16741 gcggactcgc aggcctcgac cattcctctg atggcggacg cgacctcgtc ggctttcaga
    16801 cccggcttga tccggtgagc gaacttgagg ttgagtgagg cgttgttcgg ctggagatcc
    16861 gccatcagtt gcgccatcct ctgctgtccc caggtcagat cggcggttcg cccggacggc
    16921 gcacgaaaac gaatttccaa tttttctccg tcccgcagtg acatcttctc cgttgaacag
    16981 gacaccgaaa acaattcgat tcagagagag gcttgcgtcg aaggctatcg ctggcatccg
    17041 tgcggggcaa ggtggttggc gcggcgatgg aaatggtgca tgctcgtccg gtgacattga
    17101 tccaagtcgc aggactgcgt aaggtcttcc gcaagccgga gaaggcgccg gggctacgcg
    17161 gttccctccg gcacctgctc cagcgtagat tctccgagca cgtcgctgtg gacggcatcg
    17221 atctgtctgt ggcacagggc gaggcagtgg cctacgtcgg tccgaacggc gccggcaagt
    17281 ccaccacggt gaagatgctt tccgggatcc tggtcccgac cgctggacag gtcctcgtcg
    17341 acggcttggt gccgtaccgg gcgagggtgg agaacgcgcg acgcgtcggc gtcgtcttcg
    17401 ggcagcgaac gcagctgtgg tgggacctgc ccgtacgtga ctcgctcgaa ctgctgcggg
    17461 acatgcacgg tctgggcgcc gcgcggtacc gggagacact ggcccgcctc gacgacgtcc
    17521 tcggcttggc cgaccttctc ccggtggtcg cccgtaagtt gtcgctgggg caacgcatgc
    17581 gggccgacct cgccgcggcg ctgctccacg aaccgcggat cgtctacctg gacgagccga
    17641 cgatcggctt ggacatcgcg gtgaaggacc gggtgcgttc cttcgtgcgt cggctggtgg
    17701 cggacgggac gacggtcatg ctcaccaccc acgacctcgc cgacatcgag gacatctgcc
    17761 ggcgcatcgt gatcatcgac gcgggacgtg tggtgtacga cggtgacctg cagtcggtga
    17821 aggacaccca tgtccgcgag cggtcgatgt ccttcgagct ggccgccggc ttgccgggcg
    17881 tcgatcggat cgccgcgcga ctgccgggcg ctcaggtccg cgcggggtcg gacgaccgcg
    17941 agctcacggt caccttcgac cggatgacgc tcggcgcgcg agaggtgctg gcggcagtgc
    18001 tcgccgaggc ggagatcgtc gacatgcaca tcgacgagcc ggccatcgag acggtcgtcc
    18061 ggaaggtgta cgcggggcag ttgcggcccg agcccggcgg cggggtcgat cgggagaccg
    18121 tgtcatgaca ttcgtgaccg ccggtgcggt gccgttgccg gctgataccc gatcacgccg
    18181 gatacgtgcc tatcggagca tggcccggat ggcgctgaag agccttctcg cctatcagac
    18241 gagcttcctc ttcggcatgc tggcctcggc gttcggcgtc ctgtccatgc tgtacctgtg
    18301 gcgctcggca ctcgccgccg gccctcggca aggattcgac tggccgcaga tgaaggcgta
    18361 cctgctggtg gcgttcgtcg tcggttcgct ggtgtccagc tataccgact atcgaatggc
    18421 caaccgcatc cagcagggcg acgtggccat ggacctggtt cggccggtcg actaccagtg
    18481 gtcgcgcctg gccgagagcg tcgggttcgc cgtctacgaa gccggcacgg cgatcgtggt
    18541 cgtcctggca gccgccgcga tcttcggcgg catgtcgccg ccggaccggg acaccttgcc
    18601 gctgttcatc ctgtccgcct tgctggtgct gcccctgcgg ttcggaatcg tgtacctgag
    18661 cggtctgctc gtcttctgga cacagaacta cgtgggtgtg caggccgccc ggatcgccct
    18721 gatcacgctg ttctccgggg cactcgtacc gctggccttc ctgcccgagt ggatgcgggt
    18781 catcgccacg tacctgccgt ttgtcggaat ggcgtcgacc ccggcgctgc tctacaccgg
    18841 ctcactggac ggcagcgacg cgacgaccgc cgtgctggtg caggcggcct gggcggtcgc
    18901 gctgtggtgg ctggcgcggt tgatgtggtc ggccgccgct cggaagctga cggtccatgg
    18961 tggctgaagc acgacgagcg ctgtggctct accgccgtct gctcggtgcc caggtgcgcg
    19021 ccactctcca gtacgaggcc gacttctgga tcatgagcct gtcggcagtt ctcgtgcagg
    19081 ccgtcggcgt ggtcttcctg tgggcgatct tccggagcat cccggagatc aacggctggc
    19141 agttctggga agtcgtgctc atctacgcgc tggtggtcgt cgcggaaggg ctgagcgtgc
    19201 tggtcgcgca gggagcctgg accctcgcgg tgactgtcaa cttcggacag ctggacgcga
    19261 tgctgttgcg gccctatcca ccggtcctcc aggtgctcag ctccgcggtg ggaatgaacg
    19321 gactgggcaa tctcgtcctc ggcaccggtc tgctgatcgc cgcggtgcgg cacgtcgacg
    19381 tcagttggaa cgtcggtcgc gtcgcgctcg ggctgctgct cgtggttgcg gcggccggtg
    19441 tgaagatcgg gctcaacctc ctcacgaact gcgccgcctt ctggttgcgt tccccgtact
    19501 ccatgttcgc gttctccatg cacagcttcg gggaactggc tcgttttccg gtcaccatct
    19561 acggccttgg ggtccggatc acccttaccg tcgtcctgcc ctatgcgttc atgagcttct
    19621 tccccgccgc ggctgtcctc gcgcacgggc cggctcgttg gctggggctg ctgacgccgg
    19681 tcgtcgccat ctactgcctg tggatcggga cgaccgtctt ccggtacggg ctctcacgat
    19741 atgaaagctc cggtcactga tgtgcgaaca catcggccgc cacgccgatt ccgtcgtcca
    19801 gtctctcgga gccctcggat gagtctcctc ggagggctgc gggacgtcgt gccgactcca
    19861 cccgagcacc gggtgtggat cagcagggcc gaggcgctgg acaccttgcg gtgtacgccc
    19921 gaggaactgg cgcaactggt tgccgccggc ctcgtggagg aggacggccg acacgactac
    19981 tgcgacgtgt ggaacgttgg cctgctcagc ggcaccggac gcagcagtcc ggagcggatc
    20041 atgatcttct tcgcgaggat gctgaagtcg tacggcgcgg actgggtctc cgcgcgggcc
    20101 tacgagatcg tcggctgggc ccagtgtccc cgcgcggagc actgcccgtc gtccgagtgg
    20161 agcgcgcctg tcctaccgga cgtgcagtgg cagcatgaag agatccaggc cggcagggcg
    20221 gagtggcgcg gcagggtcga actgaccggg aacaccgcca cggtgcgaga cccgagggtg
    20281 cgggaggtct gggacgacct gctgcggcgg taccgcttcc acttcacacc catgaccctg
    20341 tcctccgatg tcgccggcac caggcaccgg ggcgtcggcg actgcgactc gctgtgtcag
    20401 gtactgatgt ctgaactgct ggaccgtggt gtggcggccg agcaggagtc gggctacatc
    20461 ttcggaggcg cacgcctggg cctgcattcc tgggtacggc tcgtggacac cgacggggag
    20521 gtcaagattc tcgacccggc catggccctg ttgtccgacc tcttcttcac gcccgagtac
    20581 aaggcgttct gctgcgggtc cggcagtaac cgggtgctac gtcgcgcgag tcgcgagggc
    20641 atgttcgcgg ctcatccgtg cgtcaccgaa gacggcagga tcttctacga gttcacgctc
    20701 cggtcgatcc gccccggtcg ggcgccgggc ccgcggtgca gtgagggagc aggatgaacg
    20761 gccctgaggt ggaagtcaca gaccatgacg ggacgcgcgg cggagcgggg gccgctgccg
    20821 tcggtcgtcc ggtcgtcatc gacggccggt ctccgccgct cacctcgcac gacctgcacg
    20881 ctgacgttct cggcctgcga cgtcgcgtac cccggggcgc gaccgtggcc ctggtggggc
    20941 agagttcccg cctggtcgcc tcagccatcg tcgcactcga gggctgggcc gcccgggtcg
    21001 agttcgtggg tgacctgagt ccgaccgtag gctcggcgga ggcggtggtc ctgcgcgagg
    21061 ccggggctga tgccccagct gccgcctacg catcccacgg cgaactgtcg gccggggacg
    21121 cgagcaccga cgtgcgtacg ctctggcgtg tcttctcctc aggcacgacg gggacgccca
    21181 ccccgaccga ccacagtctc gactcgctga cgcggcgaat tcgcccggta cgcccggcgc
    21241 ggaatcccgg cgaccgcgag cagcggcggt ggggtctcct gttctctcct acccggatgg
    21301 cgggcatcca ggtcgtcctc caggcgatcc acggcgacac cctggtggac gcccaccacg
    21361 ccgccgggct cgacgagcgc ctccagctgt tcgccggagc cggcatcgac gcactgtccg
    21421 cgactccgac gatgtggcgg atgattctgc gcagcagggc ctgtgacgac ctccggctgc
    21481 aacagatcac gctgggtggt gagatcgcga cacagtcgct gatcaatgcg ttgcggcggc
    21541 ggttcgatgc gcgcgtcacg catgtctacg cgtccaccga ggccggtgcc gccttctcgg
    21601 tgagcgacgg cagggaaggt ttcccccggc attttctcga gccggctccc ggccgtgtgg
    21661 cactggagat ccgcgacggc gtcctgttcg tccgggcgcc gggaagcagc acggcgcagc
    21721 cggacggatt cgtctgcacg ggcgacctcg tcgagcctcg cggtgaccgg gtctacttcg
    21781 tcggccggaa gtcgcagacg gtgaacgtcg gaggggacaa ggtctcgccg gagcgggtcg
    21841 aggagctgat ccggcggcat cccgcagtac atgatgccgt ggtgacgccc aggcgcagcc
    21901 cgatcacggg ctggatcctg accgcccggg ttgtgccttc gcctctcggc agtgggctcg
    21961 accccgacga actgcagtcg gccctgcggt cattcgtcgc cgaccatctg ccccggtcgc
    22021 atactcccgc ctcgatcacc gcggtaaccg agttcttctt gtcgcccacc ggaaaggtca
    22081 gcagagcgtg aacgaggcgg atccccgcgg cgactgtcc
//
