LOCUS       NZ_BBVA01000002        26461 bp    DNA     linear   CON 10-SEP-2024
DEFINITION  Micromonospora sp. NBRC 110037, whole genome shotgun sequence.
ACCESSION   NZ_BBVA01000002
VERSION     NZ_BBVA01000002.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Micromonospora sp. NBRC 110037
  ORGANISM  Micromonospora sp. NBRC 110037
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Igarashi,Y., Komaki,H., Ichikawa,N., Hosoyama,A. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Micromonospora sp. NBRC 110037
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2438518)
  AUTHORS   Hosoyama,A., Ichikawa,N., Kimura,A., Ohshita,R. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 106x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001652995.1-RS_2024_09_10
            Annotation Date                   :: 09/10/2024 02:06:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,195
            CDSs (total)                      :: 6,136
            Genes (coding)                    :: 6,073
            CDSs (with protein)               :: 6,073
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 15 of 63
            Pseudo Genes (incomplete)         :: 53 of 63
            Pseudo Genes (internal stop)      :: 4 of 63
            Pseudo Genes (multiple problems)  :: 9 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2388485
            Orig. end                         :: 2414946
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBVA01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26461
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="15"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26461
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26461
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16461](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16461
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(110..124)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 20.76"
                     /tool="antismash"
     gene            295..1527
                     /locus_tag="A4R25_RS09730"
     CDS             295..1527
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027876.1"
                     /locus_tag="A4R25_RS09730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS110 family transposase"
                     /protein_id="WP_064446384.1"
                     /transl_table=11
                     /translation="MVAVACGIDWAQDHHDVAVVDETGVVVASVRINDDAAGLSQVLAL
                     LAEHDPTGGKLPVAIETSQGLLVAGLRAAGRQVFAINPLAVSRYRDRYRVSRGKSDAFD
                     AMVLANILRTDATAHRPLPADSELLQSLRVLTRAQQDAAWDQVTLTNRIRTLLRMFFPA
                     ALAAFERGGRHRLDSPAARVILAAAPTPAAAAALAPTELAALLRCAGRQRGIAAEADKL
                     HGIVRGEQMRQPAAVEQAMGLHLQGLVRQLDAVCQTLQQLEQRIDEVFTAHPDAKIVTS
                     IPGLGVQLGARLLAEIGDDRGRFADARALRAFAGAAPVTRSSGKSSFVHARRAKNDRIA
                     ATGYVWALAAVRHDSHWNTRYRSRRASGDRHIAALRRLFHLMLGKLHHCLRHNTLYDSS
                     KAFAEPATSTA"
     misc_feature    1222..1224
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1606..1620)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.59"
                     /tool="antismash"
     misc_feature    1611..1620
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     gene            1656..3224
                     /locus_tag="A4R25_RS09735"
     CDS             1656..3224
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018254410.1"
                     /locus_tag="A4R25_RS09735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ISL3 family transposase"
                     /protein_id="WP_064446385.1"
                     /transl_table=11
                     /translation="MEIIPALLPHLTGLRLDAVVVRGVGVRIDAATQTVRARCGTCSTW
                     STTRHGRYVRRLADVRLGGHEVLVALTVRRFTCVNGECGRRTFVEQVPGLTRRHARHTV
                     VAAGDLEAVAVALGGRPDSRLAQRLAVSVSRSTLIRMIRRMPDPPPVTPTVLGVDDFAR
                     RRGHRYATVLLDMHTRRPIDVLPDRTADTLAAWLHDHPGVQVICRDRGGSYADGARKGA
                     PGAVQVADRWHLLKNLSDTVEKVIRGHRRCLRAHAEPTSALVTPADEPGEAGRRAPNTR
                     QRHAAVHALRAEGLSISATARRLDMNVRTARKYAHAATAEALIGPNASSRPSVLAPFHS
                     YLRQRLTDGVHQTADLHGEILARGYQGSLRVLRDWLTINRARPAPATVVLVPSARRITA
                     WIMRPGHKLTDDERVDLADARRRCPDLDTVVGLARGFAALVRHQGTGQHLDAWIDRARR
                     AGYPEIRGFAAGLVGDRDAVVAGLAQPWSSGPVEGQVNRIKTIKRQMYGRANLDLLRKR
                     VLTNS"
     gene            complement(3722..4426)
                     /locus_tag="A4R25_RS09740"
     CDS             complement(3722..4426)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018792219.1"
                     /locus_tag="A4R25_RS09740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="creatininase family protein"
                     /protein_id="WP_030502743.1"
                     /transl_table=11
                     /translation="MNLWTTATTTEAGRHAASVAVLPVGSFEQHGSHLPLATDTIVASA
                     IAAAVADRYDLLLLPPITISCSHEHAAWPGTVSISARTLDAIITDVRESLQRSGVERLV
                     IVNGHGGNYVLSNIVQQANVAGPQLALFPNRTAWEAACQHAGIASTLHDDMHAGEIETS
                     ILLHVAPETVRDGYELSDHVAEHPHLLTLGMGAYTESGVIGRPSLAASGKGQRIVESLS
                     ASFRNTLDLLVS"
     gene            complement(4423..5658)
                     /locus_tag="A4R25_RS09745"
     CDS             complement(4423..5658)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="A4R25_RS09745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_157539011.1"
                     /transl_table=11
                     /translation="MGDVDGWRTLGVRLAQLRRAAGYNQHSFAPLTGYARSTIANVETG
                     RQRAPREFWQRCDELLGAAGSLLSLYDQAMRQQQALPPMPEEAELEAVDTHAAATAVAR
                     TSTSPVDPAIVPHWMSMLRILAASHDAFGPRRLHDVVRGELNIIRRHRAGAAGQTLREL
                     LRVESRWAEFASWTADNLGDSQDAAYWLRQSLSMAREAADGRMATYVLMRQAQRAVERG
                     DSAQAIALAEFADARKESTARDRALCAVRTAQAAALAGQRARCQSALQKAHSLVGAAEG
                     LDDPDTIGLHCTRTYVLAYEGQCHLILGQAKQSIAVLEAVLRAWPSAYRQDEALARAWL
                     ATGYANLGRADEAADQGEKALTIALDAGSMRLIKALSRVEHELGSRRVTDEAQRFRDRL
                     ALADQVVGRMGQ"
     misc_feature    6223..6236
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            6638..7375
                     /locus_tag="A4R25_RS09755"
     CDS             6638..7375
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018831754.1"
                     /locus_tag="A4R25_RS09755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_030502740.1"
                     /transl_table=11
                     /translation="MNPALGAADEHAASHVRSEPVPVPRPAPAGAASERTSRIADEFFF
                     MCHDDRTGRPRLFDSALAHGLAAGLLVELYYGGRITFERGHVRVKDIRPPQDWLQHLVL
                     DRIAAEQQHTATRVWLAFLGSSAYEQVAQRMWQSGLVRPQQAGPFWRQRTLYVPTDINT
                     AAWSWARLSQHLRNGRSLNGVDLALAGLALHTQLDTTLLDGASPAVRSHLRRLVEQSWP
                     PLRDLLADLGSVVGGAVLSHRTS"
     misc_feature    6677..6692
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.28"
                     /tool="antismash"
     gene            7414..8907
                     /locus_tag="A4R25_RS09760"
     CDS             7414..8907
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013734803.1"
                     /locus_tag="A4R25_RS09760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="APC family permease"
                     /protein_id="WP_064446387.1"
                     /transl_table=11
                     /translation="MSHSTTDTVSEVLARGRLGIPSVVFFVIAAAAPLTVVAGGATTGY
                     AVTGVAGIPVAYLVVAAVLALFSVGFVAMSRRIVNAGAFYTYVTRGLGRPAGVGAAMVA
                     LVAYNAMQIGLYGGFGAVLATFLRDQYGLHVTWWVPALIGWAVVAVLGVLRIDLNGKVL
                     AVMLVAECAVALVFDAVMVGHPAGGTVTFDTLAPSHILAAGIGAALVTAITGFVGFEGT
                     VVFSEETRDPRRTVARATYIAVAATGLLYGLSAWAMSVATGPDRIVDAARADGTDLIFN
                     LVSPHLGSSIVTVGRVLFITSLFAALLSFHHTVARYLFALGRERVLPGVLGRTSRRTGA
                     PKVGSILQSVLAVVVLIAYATVGADPIVHLFFWVTVTGGLGVLILMTVTSAAVIGFFAR
                     IAHGEGWWPAFVAPLLATLTLTGFLAATLQEFDILLGVDAHSPLRWLFPAAYAIAALAG
                     IAWALVLRATRPQVYDAIGLGADSATAPLRRTDSFRLPV"
     gene            8922..9623
                     /locus_tag="A4R25_RS09765"
     CDS             8922..9623
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013734802.1"
                     /locus_tag="A4R25_RS09765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetyltransferase"
                     /protein_id="WP_064446388.1"
                     /transl_table=11
                     /translation="MTAPSTGVTIRRATPADTDPLVSVLVDAFFDGLVADWLVPDHDDR
                     RAVYRRYFTLVLRHGLAHGHVDTTTDRSAVAIWYARPEPPPAAPPEHQAAVEAATGPYA
                     PKFTLLEAMFDVFHPREPHHYLAYVAVSPDEQRRGVGTTLLDSYHRRLDALGLPAYLEA
                     SNMRNRRLYLRLGYRAGPPLILPISGPTIWRMWRGPAGAAGTAAFPDTEQRPARRARPA
                     AASRAISARGA"
     gene            9745..9903
                     /locus_tag="A4R25_RS30565"
     CDS             9745..9903
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018805745.1"
                     /locus_tag="A4R25_RS30565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_082930958.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.1e-13, bitscore:
                     47.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTAEQTTATDGRDFDLDVSLLEVADVAGLVNLTDDGCGSTCT
                     ACTTNVA"
     gene            10001..13108
                     /locus_tag="A4R25_RS09770"
     CDS             10001..13108
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018805746.1"
                     /locus_tag="A4R25_RS09770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_197494867.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2e-202, bitscore:
                     670.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.6e-21,
                     bitscore: 71.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.9e-22, bitscore:
                     74.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSPTGSPAYRSTGAALVRAAAHPDIDLPPWPDLTEPRDALVPGW
                     VAWLRQVWTNETIVDAISHASPVLAAQVARLCAEEALTVRETRRVIQAVARYTQRLRGR
                     PTPFGLLAGVAPAVFGSRSPTRWGTAHQAVARAGAAWLADVITHLERCPDLVARLPVVA
                     NNTMTVRDDRLVLPYQPDTRPQGTTAVEVSLRYTAPVRAAITAAHTPIQVDALSAQLCA
                     AFPRAAPATVKGMLAELITRGALITSLRAPSTEPDALAYLLLQLDDVDAGGIAAVADLV
                     RALRDIHTALRRHRTAHGADGREARAQVTSRMRALGISVHEPLAVDLRLDASVTLPDQV
                     AREVERAALALTRLSAHPYGTAAWRAYHQRFYERYGIGSLVPVRDVVDPDSGIGFPDGY
                     PGTPADQPRTPLSRRDELLLALAQRAALDGADEVLLDEELIAQLELGPPRLRLPAHLET
                     SVRVHAAGEAALARGRFTVEVTSVSRGAGGLTGRFLSVLRAVDAAKLAAGLTDLPTADR
                     GTVPAQMSFPPLDPATAHVTRATQILPTVISLAEHRRPNRSVLAVDDLAVGCDGRRMYL
                     AAPDHGHRIEAVGMHALNLRTHTPPLARFLIELGRAQCAQVTAFDWGAAARAKLPFHPR
                     IRYGRAILAPATWRLEATELPDRRQPWYAWDDALDQWRARRRLPRLVQLVEADRRLPLD
                     LDESAHRVLLRTHLLTAPRAVLVEAPTPQELGWCRGRPHEVILTLHATERPPWPPLPTP
                     TPARVIGRDQCLSPAASPLLLAKLYGDIRRQDLLLAEHLPRLLTEWEVPPDWWFLRFRD
                     PDQHLRLRIALPDPSAFGPAAGRVSAWADDLRRRGLLREVQYAASYPETGRWGSGAAMQ
                     AAEAVFIADSHAVLTQLRQPVRPRRQALVAAQIAAIAVAYTGNVDAGMRWLIDHVPPTA
                     PQPVERPLFHEAVRLAHPGDDWAALRAVPGATAIVDAWKNRDIALAVYRTHLPGPHTDG
                     INSDDVLGSLMHAHYIRAVGIDFDDEDRCRYLARAAALAYFARSRP"
     aSDomain        10481..10756
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R25_RS09770_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.20E-22"
                     /identifier="RREFam001.1"
                     /label="A4R25_RS09770"
                     /locus_tag="A4R25_RS09770"
                     /protein_end="252"
                     /protein_start="160"
                     /score="71.4"
                     /tool="antismash"
                     /translation="VVANNTMTVRDDRLVLPYQPDTRPQGTTAVEVSLRYTAPVRAAIT
                     AAHTPIQVDALSAQLCAAFPRAAPATVKGMLAELITRGALITSLRAP"
     gene            13105..14391
                     /locus_tag="A4R25_RS09775"
     CDS             13105..14391
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019901917.1"
                     /locus_tag="A4R25_RS09775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_064446551.1"
                     /sec_met_domain="LANC_like (E-value: 3.9e-41, bitscore:
                     137.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPYESHGLAVAVADLLAHPDDPRLPIRQPWWQQSLALGVPGIA
                     LLHVELAAAGLRPWQRAHHWLTAATSRPVTAGPDSHPFHGAPALAHVLACAATHRPGAY
                     ARALDDLDRTIAADARRRVSAAHARIDVGELPALAEFDAIRGLAGVGAYLLRRAPDGEE
                     LPAVLGYLVRLTQPLPVGSEVLPGWWTGSGPSGRAHSRFPGGHGNNGTAHGIAGPLALL
                     ALAALHGIVVDGQTAAIATICTWLDRWCHDSKPGPLWPYWITRRQLRADRAEVHRVQRP
                     SWCYGTAGLARAQQLAALALNDHVRRATAEGTLVRALADPCQLAATTDPSLCHGHAGLA
                     HIAHRMAADALPDTAGTLGVLVPRLLGALDPDGAGPRRAAADLAAASPGLLEGAAGVAL
                     AALSCSSAGASTSSWDACLLTAPPAHPLT"
     misc_feature    13657..13659
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14401..16461
                     /gene="fxlM"
                     /locus_tag="A4R25_RS09780"
     CDS             14401..16461
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="A4R25_RS09780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_064446389.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.6e-32, bitscore:
                     108.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.2e-43, bitscore: 146.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPAWRQYTVEFPDPTAAEDVAASVLAPALAAAQDESVLHGWWY
                     VRKYPTWRWRYLADDPTSHRVEDLLETLAGQDRITNWTRGVYEPETLAFGGSAGMQVAH
                     ELFHQDSRHLLLDLPPATPLGRRELAVLLCSVLMRAAGLDWYEQGDTWAKVADLRPSPG
                     LAVPERAAELARAINRLMTVDAHSLAKTGGPLVGLGPWLDAFATAGQALADLARHGRLR
                     RGLRAVIAHHVIFHANRSGLSVQDQSTLAALAVRNVFHHTTRSTVSIAEPTPTSTSVDR
                     VTSDPADLRAALTDALRAENIIRTPGVEAAIRATPRHLFLPGVPLEQAYADAPIYTKTD
                     GRGASISAASQPRIVAMMLEQLDVRPGHRVMEAGAGTGYNAALLAALTGDNGRVVTLDV
                     DEDLVDGARKHLATAGVTNVDVILGDGALGCPDGAPYDRIIATVGAYETPTAWLEQLAP
                     NGRLVVPLRLRGAASRSIILQRHDGGWRDQGSELAVFMPLRGIGDDARRQVPITPEQDV
                     ILQVHKEQDVDAAALAGVLHTERRKIWTDVFFPPMVPYEWMDLWLACRLDNAIMRMNVQ
                     PAAIERGTVTPMFPWGAMATTRGADLAYLTIRPTPTRPDGTRLYEVGVIGHGPDGADLA
                     HQVSEEIRTWNATYRSRNVRFEIPDAPAEADPSVGRFVLPRPHHPLTVIWQ"
     gene            16458..17546
                     /locus_tag="A4R25_RS09785"
     CDS             16458..17546
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS09785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_082930959.1"
                     /transl_table=11
                     /translation="MTVELDSAVLRRFPLVARPRPIAGPLVERVDNLCALAERAVREHD
                     RAAASAAYNQAALLASDCGQPDLARRWCHEHADAYLQAVPLDARAARYALEPLVNLARL
                     HVRDRDGDAALCLLTSLFEAVSSRTDTVIDGQALPASQLTRSEDEHHEVKQWLWSVLVA
                     EGARALAGAGRWSEAYAHLERHRGIGQRMLDGRQVAVIAHVTAGDPESARALVAGTARG
                     EPWEEVVTGCLAHLCDRSSRANLDLALEGYLGLRPAQGLAVFETRLGLTLVDASTGADQ
                     RILPKLVSEVVARAVGSGDACAAREVLLHEGLMAALDGWHTTQLRTTVSASGLILVSLP
                     VWSRERIDGVLGACRAAIAEAW"
     gene            <17761..18692
                     /locus_tag="A4R25_RS32140"
                     /pseudo=""
     CDS             <17761..18692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013732871.1"
                     /locus_tag="A4R25_RS32140"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="tyrosine-type recombinase/integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GLERKTLDPYLAGWRKRVVPTLGHIPVRMITNGAVDRAVHSWIAD
                     EYSRSTVKNSLAVLVRVMEQAVRDGIIQRNPAQVTGWQREYQRAADELDDPRSLAPPDW
                     ETLTTLAAALVDRSANHFTGWADVVIFAACTAARIGEVSGVRAEDIDRETWMWTVRRQT
                     TPGPGGLIDKGTKGKRAARCR"
     misc_feature    18451..18453
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18505..18507
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18746..20380)
                     /locus_tag="A4R25_RS30570"
     CDS             complement(18746..20380)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016362.5"
                     /locus_tag="A4R25_RS30570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="restriction endonuclease"
                     /protein_id="WP_157539013.1"
                     /transl_table=11
                     /translation="MPGFEVEIDPEHQHLSEICSAYWATREDGSFAHAVKDLADTFGYP
                     SYKVSKVVSEACYARSAELCCSECGEGFIFRSRAQWTSSARYVDRRCQTCVEAEQQRQA
                     EQRKRADAARAAVIRDHFPVVEDESTPRAEDLDMQEAFALAALLEDAEELSRGVTAPIA
                     QRTDRFTPTTEYDVKLLSLLRDSGLVQLHPSSSPESFVWNDDGSLSDSFYPTHGAYYLT
                     GRGSLDDRVDDYLKSFGKISSRSSWPDRWVEQFPSFWLDVAVAECKAYLVNMLKRHGLE
                     FAPGQKTDDVFRRALKWYSIGQVFYFIWRAAKESAAYRVREKVPAKQAANSAVTRISAD
                     VDRAYAQGWQVSVYRRDSRLPLSTLSHLLFVRSLDLDDPMAYSPIDLPVRRPGLELAWS
                     NVDSGAFERLIFQLVVETDGYENVDWLMHTNAPDHGRDVSATRLRRDPLSGHSSQRVAI
                     QCKHWLSRPVRDVDVSSAIVSIGHWQDPPFDVLVIATSGRFTTDAVAWIERHNARGGRP
                     SIEVWNDARLEALLSERPHLIRSYELR"
     misc_feature    complement(19199..19201)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(19808..19810)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     tRNA            complement(20513..20586)
                     /anticodon=(pos:complement(2409035..2409037),aa:Pro,
                     seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="A4R25_RS09795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Pro"
     gene            complement(20513..20586)
                     /locus_tag="A4R25_RS09795"
     gene            complement(20740..22122)
                     /gene="der"
                     /locus_tag="A4R25_RS09800"
     CDS             complement(20740..22122)
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="der"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788817.1"
                     /locus_tag="A4R25_RS09800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="WP_176722856.1"
                     /transl_table=11
                     /translation="MELREPEVDSGEPAGPQPVVAVVGRPNVGKSTLVNRIIGRRQAVV
                     EDIPGVTRDRVPYDAQWNGRAFTVVDTGGWEPDAKDRAAAIAAQAETAVATADVVLFVV
                     DAMVGATDVDEAAVKMLRRSAKPVILIANKADNTTIEMEATSLWSLGLGEPFPISALHG
                     RGSGDLLDAILDALPEAPAIVENRPRGPRRVALVGRPNVGKSSLLNRFSGEERAVVDSV
                     AGTTVDPVDSLVEIGGETWQLVDTAGLRKRVGKASGTEYYASLRTASAIEAAEVAVVLI
                     DSSEVISEQDQRILTMVVESGRALVIAFNKWDLVDGDRRYYLDKEIDRELRRIPWAIRL
                     NLSAKTGRAVDKLAPALRKALASWETRIPTAQLNQWLTALVQATPHPVRGGRAPRILFA
                     TQAGAAPPRFVLFTTGPLDAGYQRFVERKLREEFGFEGSPIEISVRPRKKLGPGGRGKA
                     HG"
     gene            complement(22143..22823)
                     /gene="cmk"
                     /locus_tag="A4R25_RS09805"
     CDS             complement(22143..22823)
                     /EC_number="2.7.4.25"
                     /GO_function="GO:0004127 - (d)CMP kinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /gene="cmk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477402.1"
                     /locus_tag="A4R25_RS09805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(d)CMP kinase"
                     /protein_id="WP_064446391.1"
                     /transl_table=11
                     /translation="MEENVPAGRCVVAVDGPSGSGKSTVSRRLAAGLGARYLDTGAMYR
                     ALTWAVLRSGVELTDTESVAKVAAEADLRIGTDPQGYAVTVDGTDVSTAIRGAEVTAAV
                     SAVAAVAAVRELLVDRQRRVIADAGRIVVEGRDIGSVVAPDAELKVYLTASEAARAKRR
                     SAEDAADVAATAADLARRDRLDSTRKVNPLQQAPDAVVLDTTELGIDEVVARLREMLTE
                     RGAA"
     gene            complement(22994..23764)
                     /locus_tag="A4R25_RS09810"
     CDS             complement(22994..23764)
                     /EC_number="5.4.99.-"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1154: Pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019871752.1"
                     /locus_tag="A4R25_RS09810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pseudouridine synthase"
                     /protein_id="WP_043324891.1"
                     /transl_table=11
                     /translation="MRRDDRAPKPDAPVYEGAERLQKVLAAAGVGSRRACEDLIFRRRV
                     TVNGRVAQLGDKADPARDVIVVDGERLQADVRLVYVAMNKPRGVVTTMADEKGRTELAD
                     FIGARLEQRVYHVGRLDADSEGLLLLTNDGTLAHKLMHPSYEVLKTYLAEVAGPIPRNL
                     GKRLAAGVELEDGPVKVDGFKLVDTLGKTAQVELTLHEGRKHIVRRLMAEVGHPVSRLI
                     RTSIGPIKLGDLRTGRLRRLTNAEVAALFKAVGD"
     gene            complement(23751..24755)
                     /gene="scpB"
                     /locus_tag="A4R25_RS30575"
     CDS             complement(23751..24755)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scpB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018809647.1"
                     /locus_tag="A4R25_RS30575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SMC-Scp complex subunit ScpB"
                     /protein_id="WP_082930961.1"
                     /transl_table=11
                     /translation="MSDQERRDSLADQAAAWVPPWERPAPPRPAPDDSDAPAEHPDPDI
                     PDTTDSREADLDATPDSSADLGSEGPSEGPIPSKIATVQGDLGTGTPLGGRDRTKISGE
                     AGTDDAGGDVGLPARDAAPGAGGGAGAEGVPAKRGRRRAAPEPVPAPVLDDAELRGALE
                     AILLVVDQPVSELVLAEVLEQSPERVGAMLDEIAAGYTAAGHGFDLRRAAGGWRLYTRP
                     EYATYVERFVLDGQSVRLTQAALETLAVVAYRQPVTRSRISAIRGVNCDGVLRTLVGRG
                     LVEECGTEADSGAYLYRTTTMFLEKLGLNSVDDLPPLAPFLPDDVEELADATR"
     gene            complement(24760..25827)
                     /locus_tag="A4R25_RS09820"
     CDS             complement(24760..25827)
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477405.1"
                     /locus_tag="A4R25_RS09820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ScpA family protein"
                     /protein_id="WP_043324893.1"
                     /transl_table=11
                     /translation="MTAPPLDPPHGAGDPAVAAELAAEVDGVVPADAGTGEQASGFTVR
                     LDNFTGPFDLLLQLISKHKLDVTEVALHKVTDEFIAYLRAMGDQWDLDETSEFLLVAAT
                     LLDLKAARLLPSAEVEDEEDLALLEARDLLFARLLQYKAYKEAAAHIAELEAVGGRRYP
                     RAVTLEPRYAEALPDLVLGIGPERLRKLAVKAMSPKPVPEVSIAHVHMVRVSVREHAGI
                     IADRLRRAGIATFSLLCADCEMTLEVVARFLALLELYRQGLVAFVQEQALEELTVRWTG
                     PVDGEAELTVDEYAGSPEPTTTSVPAAPADAAAAPADVGAGVSDAAVPGDVAADAASDA
                     AVPSETADEHAPTQE"
     misc_feature    complement(26290..26306)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.69"
                     /tool="antismash"
ORIGIN
        1 ggggaatcga gagcggcgcc tcgttgagga tcgtggccgc tgctgacgcc tgtagaagtg
       61 gcggggcgtt gaccctggat atcgagaggg gcgcgtggcg gtcacggcga tcgacgagga
      121 tgatcgtttt gtggttcgcc ggcgggctga gccttggtca gtcgcaggcc aggagccttg
      181 cgcgagttcg ggcgccgccg gtggcgaggc gaacggctcg tgagatgtcg tgcggcaagc
      241 actgtccatt agggcgtcgc gcctcgctgt ggtccatgac agggaggagc aacggtggta
      301 gcggtggcgt gtggcatcga ctgggctcag gatcaccatg atgtagctgt cgtcgacgag
      361 acgggcgtcg tggtggcatc ggtcaggatc aacgacgatg ccgccggcct cagtcaggtt
      421 cttgcgctgc tggccgagca tgatccgacc ggcgggaaac tgcctgtagc gatcgagacg
      481 agtcagggac tgctggtggc tggtctccga gccgcgggtc gacaggtgtt tgcgatcaat
      541 cctttggcgg tgtcgcggta tcgggaccgg tatcgggtct cgcgcggcaa gtcggacgcg
      601 ttcgacgcga tggtgctggc gaacatcctg cgaaccgatg cgaccgcgca tcggccactg
      661 cccgccgaca gtgagttgct gcagtcgctg cgggttctga cccgggcgca gcaggacgct
      721 gcgtgggacc aggtcacgct cactaaccgg atccggacgc tgctgcggat gttctttccc
      781 gccgccctgg cggcgttcga gcgcggcgga cggcaccggc tcgactcacc ggccgcgcgg
      841 gtgatcctcg ccgcggcgcc gacgcctgcg gccgcggctg cgctggctcc caccgagctc
      901 gcggcgttgc tgcgctgcgc tggccgccaa cgcggcatcg ccgccgaggc ggacaagctg
      961 cacggcatcg tccgtggcga gcagatgcgt caaccagcag ccgttgagca ggccatgggc
     1021 ctgcatcttc aaggactggt gcggcaactc gacgcggtct gccagacgtt gcagcagctg
     1081 gagcagcgca tcgacgaggt gttcaccgcc caccccgacg cgaagatcgt caccagcatc
     1141 cccggtctcg gcgtgcagct cggcgctcgg ctgctggccg agatcggcga cgaccgcggc
     1201 cgcttcgccg acgcccgcgc gttacgtgct ttcgccggtg ccgcgcctgt gacccgttcc
     1261 tcgggcaaga gcagtttcgt gcacgctcgc cgcgccaaga atgaccggat cgctgctacc
     1321 ggatacgtgt gggcgctggc cgcggtccgg catgactccc actggaacac ccgctaccga
     1381 tcccgccgcg cctccggcga caggcacatc gccgccctgc gtcggctgtt ccacctcatg
     1441 ctcggcaagc tgcaccattg cctgcgacac aacaccctct acgactccag caaggctttc
     1501 gccgaacccg caacctcaac tgcttgacag ccaccgttgg tgagatgtct cgatgtaggc
     1561 gaagatcgcg ttctcggtgt caacgccggc tcaaccttgg ctctggcaca cattttgtga
     1621 gtcgcgctcg gcggtagttc gggttgggtg ccggaatgga gatcattccg gcgttgctgc
     1681 cgcacctgac gggcctgcgg ttggacgcgg tggtggtccg gggcgtcggg gtcaggatcg
     1741 atgcggcgac acagactgtg cgggcgcggt gtggcacttg cagcacctgg tcgaccacaa
     1801 ggcatggtcg ctatgtgcgg cggctggccg atgtcaggtt gggtggtcac gaggtgctgg
     1861 tcgcgttgac ggtccgccga ttcacctgcg tgaacggcga gtgcgggcgg cggaccttcg
     1921 ttgagcaggt cccgggcctg actcgtcggc atgcccgtca caccgtcgtg gcggccggtg
     1981 acctggaggc cgtcgcggtg gcgctgggcg gtcgaccgga cagcaggttg gcgcagcggt
     2041 tggcggtgtc ggtctcccgg tcaacgttga tccggatgat ccggaggatg cccgacccgc
     2101 cgccggtgac gccgacggtg ctgggcgtgg acgactttgc ccgccgccgt gggcaccgct
     2161 acgcgaccgt gctgctcgac atgcataccc gccgaccgat cgacgtcctg cccgaccgca
     2221 ccgccgacac cctcgccgcc tggctgcacg accatcccgg tgttcaggtc atctgccgcg
     2281 accgaggcgg cagctatgcc gacggcgccc gcaagggagc acctggcgcg gtccaggtcg
     2341 ccgaccggtg gcacctgctg aagaacctca gcgacaccgt cgagaaagtc atccgcgggc
     2401 accgccgctg cctacgcgcc cacgccgaac caacatctgc cctggtcacg ccggccgacg
     2461 agccgggcga ggcggggcgt cgggcgccga acacgcgcca acgccacgcg gccgtgcacg
     2521 ccctgcgagc cgaagggctg tcgatcagcg cgaccgcccg ccgactcgac atgaacgtca
     2581 gaaccgcccg caagtacgcc catgccgcca cggccgaggc gttgattggc ccgaatgcca
     2641 gcagccgacc cagcgtcctc gccccgttcc actcctacct gcggcaacgc ctcaccgacg
     2701 gcgttcatca gaccgctgac ctgcacggcg agatcctggc tcgcggctac caaggcagcc
     2761 tgcgggtgct gcgggactgg ctcaccatca accgcgcccg gcctgcccct gcgaccgtag
     2821 tcctggtgcc gtcggcccgg cggatcaccg cctggatcat gcgacccggc cacaaactca
     2881 ccgacgacga acgcgtcgat ctcgccgacg cccgccgccg ctgcccggac ctcgacaccg
     2941 tcgtcggcct cgcccgcggg ttcgccgcgc tggtccgcca ccaaggcacc gggcagcacc
     3001 tcgacgcctg gatcgaccgc gcccgccgcg ccggataccc cgagatccgc ggcttcgccg
     3061 ccggtcttgt cggcgaccgc gacgccgtcg tcgccggcct cgctcagcct tggagttcag
     3121 gtccggtcga gggccaggtc aaccgcatca agacgatcaa gcgacagatg tatggccggg
     3181 cgaacctcga cctcctccgc aaacgcgtcc tgaccaactc gtgagccgcc atcaagatca
     3241 atcacagaat ctgcgccaga gccagttttc aggcggagcc gacaggggcg gctccccgcg
     3301 cacgcggggg taatcccatc gtcgccagcc accccaaggg ctacctcatc tgctccccgc
     3361 gcacgcgggg gtgatccgac ccgcgcggac gcggtggcgc tgctcaccga ctgctccccg
     3421 cgcatgcggg ggtgatccct tcgagcgggt cagcctcgac gaggtgcccg catgctcccc
     3481 gcgtacgcgg gggtgatccg gcgctggaga cgatcgacgg cccgacgtac gcctgctccc
     3541 cgcgcgcgca ggggtgacct cgggaagttc gccaccgcac cggcgtggtc gatctgctcc
     3601 ccgcgcacgc agcggtgatc cccaggccga gacggggaac gcggagcgcc gcgaccgctc
     3661 cccgcgcacg gagggctaaa tcgttcacct cgtcgagttc tgttcctcca agatgcaggt
     3721 attacgacac caacaagtcc aatgtgttcc ggaagctagc gctcaggctt tcaacgatcc
     3781 gctgcccctt gccactcgct gcgagtgagg gacgtccgat caccccggac tcggtgtaag
     3841 cgcccattcc aagcgtgagc aggtgcggat gctcggcgac gtgatcgctt agctcgtagc
     3901 cgtcgcgcac ggtctccggc gccacgtgaa gcagaatcga ggtctcaatc tccccggcgt
     3961 gcatgtcgtc atgcagggtg ctcgcgatgc cggcatgctg gcatgcagcc tcccaggctg
     4021 tccgattcgg gaacagcgcg agctgaggtc cggcgacgtt ggcctgctgc acgatgttcg
     4081 agagcacgta gttcccgccg tgaccgttca cgatcacgag gcgctccacg cccgagcgct
     4141 gaagcgactc cctcacatcg gtgatgatcg cgtctagggt gcgtgcggag atgctcaccg
     4201 ttccgggcca ggcggcgtgc tcgtgtgagc aggagattgt gatcggtggg agtagcagca
     4261 ggtcgtaacg atcagccacg gctgcggcga tcgcgctggc gacgatcgtg tcggtggcca
     4321 gcgggaggtg ggaaccatgc tgctcaaagc tgccgactgg cagaacggct actgatgcgg
     4381 cgtggcggcc ggcctccgtg gtcgttgctg tggtccatag gttcactggc ccattctgcc
     4441 gactacttga tccgcaaggg caagtcggtc gcggaaacgc tgcgcctcgt ccgtcactcg
     4501 tcgagacccg agctcgtgct ccacacgact cagcgccttg atcagacgca tagatccggc
     4561 atcgagtgcg atagtgagcg ccttctcgcc ctggtcagca gcttcatccg ctcgaccgag
     4621 gttcgcgtag ccggttgcga gccaggcgcg ggcgagcgct tcgtcctgcc ggtacgcgga
     4681 tggccaggcc ctcagcacag cttcaagaac agcgatggac tgcttcgcct ggcccagtat
     4741 cagatgacat tgcccttcgt acgccagcac gtaggtgcgg gtgcagtgca ggccgatggt
     4801 gtctgggtcg tcgaggcctt cggcagctcc taccagtgaa tgcgccttct gcagcgcgga
     4861 ttggcagcgt gctcgttgtc cagcgagcgc ggcggcctgg gcggttcgga cggcgcacag
     4921 cgcccgatca cgggctgtcg actccttcct ggcatcggcg aactcggcga gggcgatagc
     4981 ttgggcgctg tcccctctct cgacagcgcg ctgcgcctgc cgcatgagga cgtaggtcgc
     5041 catcctgccg tcagccgctt ctcgggccat cgatagtgac tgccgcaacc agtacgccgc
     5101 atcctggcta tcgccgaggt tgtcggcggt ccaactggcg aactccgccc accgcgactc
     5161 gacccgcagc agctcccgca gggtttgccc ggctgcgccg gcgcgatgcc ttcggatgat
     5221 gttcagctca ccccgaacga cgtcgtggag ccgacgtggg ccgaacgcgt cgtgggaagc
     5281 ggcgaggatg cggagcatgc tcatccagtg cggcacgatg gcggggtcaa caggactcgt
     5341 tgacgtcctt gccaccgcgg tggccgcagc atgcgtgtcg acggcttcaa gctccgcttc
     5401 ctcaggcatg gggggcagag cctgctgttg gcgcatcgcc tggtcataga ggctgagcag
     5461 tgagccggct gccccgagga gctcatcgca gcgctgccag aactcacgcg gcgccctctg
     5521 ccggccggtc tcgacgttcg cgatcgtgct gcgggcgtag ccagtcaggg gtgcgaaaga
     5581 gtgctggttg tagccggcgg cgcgtcgaag ctgcgctagc cggacgccca gcgtccgcca
     5641 accgtctacg tcgcccatcg gcacctggca cccttctcct cggcggtcgc gaatgtcggc
     5701 agcaagcgac gctgctcctc aatcgagctg gaactcaaca gcctgccggt agcctatgcg
     5761 ctccggccgc cagcgaatgg cccttgatgt tcccgcgccc tcgtccccgg atgacgacaa
     5821 gcagcgtgcg cgttgctggt cggatcgtga cggatttcag gggatcccgt cactggggtt
     5881 gtcggtaaga gggtcggcgg attccgacaa tcctccgaca ttctgcccgt cgctcaacgt
     5941 gccgatcggc acggcggcca accctgaagc gtctcgccgc aggcgctttc gacttccagg
     6001 agtaggaccc tcctgatcag ttgaccgagc atgtcaacgc agtgtcgtag atccaatccc
     6061 gaccgttccc gacaccggtc cacctttcgt tggctggtca ggcaccagca agtgcaggac
     6121 cggcgcctct ccggcgcgcg aacggtccct gcacccatca accggggcgc gtagtcggag
     6181 ccgggagagg cccggccgcg catcccacga ggaggtgacg ggatgacgcg tatcaaatgg
     6241 ttcgtctccg ggcaggatca tcagtctttc acgcctttcg gcatcgccag cacggcgacg
     6301 ctcgcccggc ttcgcgacga gccggaccac gaatgcagca ggaggcacct gcctcggtcc
     6361 gcgctacgcg cctccgccgc ctcgctgccc tgccgcgacc ccgccccgtg accggcgccg
     6421 aggagagcga ccgtcccgtc gaccgcttcg acgcggctcg ccggaccgtg ctcgcccaca
     6481 aggagggcgg cgcctgcttt cagtgccacg acggcgtatg tcgccagaac gagtgggcgc
     6541 tggaggagct gtcccgtcat ccaggtggcc gtcgcctcct cgtacggctc cgacttcttc
     6601 gatacgcaga cgacacgatt caggaaggcc agccgcggtg aatccagccc tcggcgccgc
     6661 tgacgagcac gccgcctcgc atgtccgttc cgagcctgtc ccggtccccc gtccggcgcc
     6721 cgccggcgcc gcctccgagc ggaccagccg gatcgcggac gagttcttct tcatgtgcca
     6781 cgacgaccgg accggccgac ctcggttgtt cgactcggcg ttggcgcacg gcctggccgc
     6841 tgggctgctc gtcgagctct actacggcgg gcggataacg ttcgagcgcg ggcacgtgcg
     6901 cgtcaaggac atccggccgc cgcaggattg gctccagcac ctggtcctgg accggattgc
     6961 ggccgagcag cagcacaccg cgacccgggt gtggctcgcc ttcctcggct cgtccgccta
     7021 tgagcaggtc gcccagcgga tgtggcagtc gggtctggtg cgaccgcagc aggcgggccc
     7081 gttctggcgg caacgcaccc tgtacgtgcc gaccgacatc aacaccgcgg cctggtcgtg
     7141 ggcgcggctg tcccagcacc tgcgcaacgg ccggagcctg aacggcgtgg acctcgccct
     7201 ggccggcctg gcgctgcaca cccagctgga cacgacgctg ctcgacggcg cctcgccggc
     7261 ggtgcgctcg catctgcggc ggttggtcga gcagtcgtgg ccgccgttgc gggatctgct
     7321 cgccgatctc ggcagcgtcg tcggcggcgc ggttctgagc caccgcacct cctgacggca
     7381 cccaccccat ccactcttcg cgaaagagac ctgatgtcgc attcgactac tgacactgtt
     7441 tccgaggttc tggcgcgcgg ccggctcggg atcccctcgg tggtgttctt cgtcatcgcc
     7501 gccgccgcgc cgctgacggt ggtcgccggc ggtgcgacca ccggctacgc ggtcaccggc
     7561 gtggcgggta ttccggtggc gtaccttgtc gtcgccgccg tgctggcgct gttctcggtc
     7621 gggttcgtgg ccatgtcccg gcggatcgtc aacgccggcg cgttctacac ctacgtcacc
     7681 cgagggctcg gccgtccggc cggtgtcggc gcggcgatgg tcgcgctggt ggcgtacaac
     7741 gcgatgcaga tcggcctgta cggcgggttc ggcgcggtcc tcgcgacgtt cctgcgcgat
     7801 cagtacggcc tgcacgtcac ctggtgggtg ccggcgctga tcgggtgggc tgtagtcgcc
     7861 gtgctgggcg tgctgcgcat cgacctcaac ggcaaggtcc tggcggtcat gctcgtcgcc
     7921 gagtgcgcgg tcgcgctggt cttcgacgcg gtgatggtcg ggcaccccgc cggcgggacg
     7981 gtcaccttcg acaccctcgc cccgtcgcac atcctcgccg cgggtatcgg cgccgcactg
     8041 gtcacggcca tcacgggttt cgtcggcttc gagggcactg tggtgttctc cgaggagacc
     8101 cgcgacccac gtcggacggt cgcccgggcc acctacatcg cggtggccgc caccggcctg
     8161 ctctacggcc tgtccgcctg ggcgatgtcc gtcgccaccg gcccggacag gatcgtcgat
     8221 gcggcccgcg ccgacggcac cgacctcatc ttcaatctcg tctcaccgca cctcgggtcc
     8281 agcatcgtga ccgtcgggcg ggtcctgttc atcaccagcc tgttcgccgc gctactgagc
     8341 ttccaccaca ccgtcgcccg gtatctgttc gctctcggcc gggagcgggt cctgcccggc
     8401 gtactgggcc ggaccagccg ccgcaccggc gccccgaagg tcgggtcgat cctgcagagc
     8461 gttctcgcgg tggtcgtcct catcgcctac gccactgtcg gcgcggaccc gatcgtgcac
     8521 ctgttcttct gggtcacggt gaccggtggc ctcggcgtcc tgatcctgat gaccgtcacc
     8581 tccgccgccg tgatcggctt cttcgcccgt atcgcccacg gcgaaggctg gtggccggcc
     8641 ttcgtcgcgc cgctgctcgc cacgctcacg ctgaccgggt ttctcgccgc cacgctacag
     8701 gagttcgaca tcctcctcgg cgtcgacgcg cactcaccgc tgcgctggct cttcccggcc
     8761 gcctacgcca ttgccgccct cgccggcatc gcctgggcat tggtcctgcg cgcaacgcgg
     8821 ccgcaggtct atgacgccat cggactcggc gccgacagcg ccaccgcgcc cctgcgccgc
     8881 accgacagct tccgcctgcc ggtctgaaca aggagctcac catgaccgcc cccagcaccg
     8941 gcgtgaccat ccgtcgcgcc actcccgccg acaccgaccc cttggtctcc gtactcgtcg
     9001 acgcgttctt cgacgggctg gtcgccgact ggctggtccc tgaccacgac gaccgtcgcg
     9061 ccgtctaccg ccggtacttc accctcgtcc tgcgtcacgg gctcgctcac ggccacgtcg
     9121 acaccaccac cgaccggtcc gccgtcgcga tctggtacgc ccggcccgaa cctccgcccg
     9181 cggcgccgcc ggagcaccag gcggcggtgg aagccgccac cggaccgtac gcgccgaagt
     9241 tcaccctcct cgaggccatg ttcgacgtgt tccacccccg cgaaccgcac cactacctcg
     9301 cgtacgtggc ggtcagcccc gacgaacagc gccgcggcgt cggaaccacc ctgctcgaca
     9361 gctaccaccg ccggctcgac gcgctgggcc tgcccgccta cctggaggcc agcaacatgc
     9421 gcaaccgcag gctgtacctg cggctcggct accgggctgg accgccgctg atcctgccca
     9481 tcagcggacc cacgatctgg cggatgtggc gcgggccggc cggagccgcc ggcacggcgg
     9541 cgtttcccga caccgagcaa cgaccagctc ggcgagcccg gccggctgcc gcttccaggg
     9601 ccatatcagc ccgtggtgcc tgaccacggt cgcttcaagc tccgtccgca tcgggcggta
     9661 ggggtgacgc gtcaccggga cgcggccacc ccggcaccac ctcgggtcac cacggcccgg
     9721 gagatctcga gatcggagga agacatgtcc accagcaccg cggagcagac cacggccacc
     9781 gacggcaggg acttcgacct ggacgtcagc ctgctggagg tggctgacgt cgccggcctg
     9841 gtcaacctga ccgacgacgg ctgcggcagc acctgcaccg cctgcaccac aaacgtcgcc
     9901 tgaccgacga aacctccccc gaaaggccgg ccggcgcggc aacacgcccc cattctccgc
     9961 gccggccggc accccaaccg acatccaccc gaggtgcagc gtgcgctctc ccacaggctc
    10021 tccggcatac cggtcgaccg gtgccgcgct cgtccgcgcg gccgcccacc ccgacatcga
    10081 cctgccgccg tggcccgacc tgaccgaacc acgcgacgcc ctcgtccccg gctgggtggc
    10141 atggctgcgg caggtgtgga cgaacgaaac catcgtcgac gcgatcagcc acgccagccc
    10201 ggtactcgcc gcgcaggtcg ccaggctgtg cgccgaagag gccctcaccg tccgggagac
    10261 ccggcgggtt atccaggccg tcgcccgcta cacgcagcgc ctacgcggcc ggccgacccc
    10321 gttcggtctc ctcgccgggg tggcacccgc cgtgttcgga tcacgctcgc ccacccgatg
    10381 gggcaccgca caccaggccg tcgcccgggc gggcgccgcc tggctcgccg acgtgatcac
    10441 ccacctggaa cgatgcccgg acctggtcgc ccggctcccg gtggtcgcga acaacaccat
    10501 gacggtacgc gacgaccggc tcgtcctgcc ctaccagccg gacacccgac cgcagggcac
    10561 gacggctgtg gaggtgtcgc tgcggtacac cgcgccggtc cgcgccgcga tcaccgccgc
    10621 ccacaccccg atccaggtcg acgcactgtc cgcgcagctg tgtgccgcat tcccgcgcgc
    10681 tgcaccggcg accgttaagg ggatgctcgc cgagctgatc acccgcggcg cgctgatcac
    10741 cagcctgcgc gcgcccagca cggaacccga cgccctggcg tacctgctgc tccagctcga
    10801 cgacgtcgat gccggcggca tcgcggcggt cgccgacctg gtacgcgccc tgcgcgacat
    10861 ccacaccgcg ctacgacgcc accgcaccgc ccacggcgca gacggtcgcg aggcccgcgc
    10921 ccaggtgacc tcccggatgc gtgctctcgg catctccgtc cacgagcctc tcgcggtgga
    10981 tctccggctg gacgcgtcgg tcacgctgcc ggaccaggtg gcgcgggagg tggaacgcgc
    11041 cgccctggcg ttgacccggc tcagcgccca cccctacggc accgcggcgt ggcgcgccta
    11101 ccaccagcgc ttctacgaac ggtacgggat cggctcgctg gtgccggtac gcgacgtcgt
    11161 cgacccggac agcggcatcg gcttccccga cggatacccc ggcaccccag cagaccagcc
    11221 acgaacaccc ctgtcccgcc gcgacgagct gctcctcgcc ctcgcccagc gcgccgccct
    11281 ggacggcgcg gacgaggtgc tgctcgacga ggagctgatc gcacaactgg agctgggacc
    11341 gccacggctg cggctgccgg cacacctgga gacgagcgtc cgcgtgcacg ccgccggcga
    11401 agccgccctg gcgcgcggca ggttcaccgt cgaggtcacc tccgtgtcgc ggggcgccgg
    11461 cggactcacc ggccggttcc tcagcgtgct gcgggcggtc gacgcggcga agctggccgc
    11521 cggcctgacc gacctgccca ccgccgatcg cggcacggtg cccgcccaga tgtcgttccc
    11581 gccgctggat cccgcgaccg cccacgtcac ccgcgccacg cagatcctgc ccactgtcat
    11641 cagcctggcc gagcaccggc gcccgaaccg gtcggtactc gccgtcgacg acctggcggt
    11701 cggctgcgac ggccgacgca tgtacctcgc tgcacccgac cacggccacc gcatcgaagc
    11761 cgtcggcatg cacgcgctca acctgcgcac ccacacccca ccactggccc ggttcctcat
    11821 cgaactcggc cgcgcccagt gcgcccaggt caccgctttc gactggggcg ccgccgcccg
    11881 ggccaagctg ccgttccatc cccgcatccg ctacgggcgc gcgatcctcg cccccgccac
    11941 ctggcggctg gaagctaccg agctgcccga ccggcggcag ccctggtacg cctgggacga
    12001 cgccctcgac cagtggcggg cccgcaggcg cctgccccgg ctggtgcagc tggtcgaagc
    12061 cgaccggcgt ctgccgctgg acctcgacga gtccgcgcac cgcgtcctgc tgcgcaccca
    12121 cctgctcacc gcaccgcgag cggtcctcgt ggaagcaccc accccgcagg aactcggctg
    12181 gtgccgcggc cgtccgcatg aggtcatcct gacgctgcac gccactgagc gaccaccctg
    12241 gccgcccctg cccacaccga cgccggcccg cgtcatcgga cgagaccagt gcctaagccc
    12301 tgccgcttct ccgctgctgc tcgcgaaact ctacggagac atccgccgac aagacctcct
    12361 cctcgccgag cacctgcccc gactgctcac tgagtgggag gtgccgccgg actggtggtt
    12421 cctccggttc cgcgacccgg accagcatct ccgcctccgc atcgccctgc ccgacccgtc
    12481 ggcattcgga ccggccgccg gacgtgtcag cgcatgggcc gacgatctac gccgacgtgg
    12541 cctgctgcgg gaggtccagt acgccgcgtc ctaccccgag accgggcggt ggggatccgg
    12601 tgcggccatg caggccgccg aggcggtctt catcgccgac tcccatgccg tcctcacgca
    12661 gctacgccag cccgtccgcc cgcgccgaca ggcactcgtc gccgcgcaga tcgccgctat
    12721 cgccgttgcc tacaccggca acgtcgacgc cggcatgcgc tggctcatcg accacgtacc
    12781 cccgaccgcg ccgcagccgg tcgagcggcc gctgttccac gaagccgtac gactcgccca
    12841 ccccggcgac gactgggccg cactgcgcgc tgtccccggc gccaccgcca tcgtcgacgc
    12901 ctggaagaac cgcgacatcg ccctcgccgt ctaccggacc cacctacccg gaccgcacac
    12961 cgacggcatc aacagcgacg acgtcctcgg ctccctcatg cacgcccact acatccgcgc
    13021 ggtcggcatc gacttcgacg acgaggaccg gtgccgctac ctcgcccgcg ccgccgccct
    13081 ggcctacttc gcccggagcc ggccatgacc cttccatatg agagccacgg cctcgctgtc
    13141 gcagtcgccg atctgctcgc ccatcccgac gacccacggc tgccgatccg gcaaccctgg
    13201 tggcagcagt cactcgccct cggcgtaccc ggcatcgccc tgctgcacgt cgaactggca
    13261 gcggcagggc taagaccctg gcaacgcgcc caccactggc tcaccgccgc taccagccga
    13321 ccggtaacgg cgggccccga cagccaccca ttccacggcg cacccgcgct cgcccacgtc
    13381 ctcgcctgcg ccgccaccca ccggcccggc gcgtacgccc gcgcgctcga cgacctcgac
    13441 cggacgatag ccgcggacgc ccggcgccgc gtgagcgccg cgcacgcccg catcgacgtc
    13501 ggggaactac cagcgctcgc cgagttcgac gccatccgag gattggccgg ggtcggggcg
    13561 tacctgctcc gccgagcacc cgacggcgag gaactgcccg cggtgctcgg gtatctggtc
    13621 cggctgacgc agcccctacc cgtcggcagc gaggtgttac caggctggtg gaccggcagc
    13681 gggccctccg gccgcgccca ctcccgcttc cccggcggac acggcaacaa cggcacggcc
    13741 cacggcatcg ccggaccctt ggcgctactg gcgctcgcgg ccctgcacgg cattgtcgtc
    13801 gacggtcaga ccgctgccat cgcaacgatc tgcacctggc tcgaccgatg gtgccacgac
    13861 tccaagcccg gtcccctctg gccgtactgg atcaccagac ggcaactccg ggcggaccgc
    13921 gccgaggtcc accgcgtgca gcggccgtcc tggtgctacg gcaccgccgg cctggcgcgc
    13981 gcccagcaac tcgccgccct ggccctgaac gatcacgtcc gccgcgccac ggccgaaggc
    14041 acactcgtac gcgctctcgc tgacccgtgc cagctcgcgg cgaccaccga cccgtcgctc
    14101 tgccacggcc acgccggcct ggcccacatc gcgcaccgga tggccgccga cgccctgccc
    14161 gacaccgccg ggaccctcgg cgtgctggtc cctcggcttc tcggcgcgct cgacccggac
    14221 ggcgccgggc cccggcgtgc cgcagctgac ctggccgccg cgagccctgg cctgctcgaa
    14281 ggcgccgccg gcgtcgcgct ggcggccctc agctgcagca gcgcgggcgc gtcaaccagc
    14341 tcctgggacg cctgcctgct caccgccccg cctgcccatc ccctgacgtg aggacgtcga
    14401 atgccaacac ccgcctggcg gcagtacacc gtcgagttcc ccgaccccac cgcagccgag
    14461 gacgtcgccg cctccgtcct ggccccggcg ctggccgccg cgcaggacga gagcgtgctg
    14521 cacgggtggt ggtacgtccg gaagtacccc acctggcggt ggcgctacct tgccgacgac
    14581 ccgacctccc accgcgtcga ggacctgctg gagacactcg cgggccagga tcgaatcacc
    14641 aactggaccc gaggcgtcta cgaaccggag accctggcct tcggcgggtc ggccggcatg
    14701 caggtagccc acgagctgtt tcatcaggac agccggcacc tgctactcga cctgcctccc
    14761 gccaccccgc tgggaaggcg cgagctcgcc gtgctgctgt gcagcgtcct gatgcgcgcc
    14821 gccggtctgg actggtacga gcagggcgac acctgggcga aggtcgccga cctccggccc
    14881 tcccccggcc tcgcagtgcc agagcgggcc gccgaactgg cccgagcgat caaccggctc
    14941 atgaccgtcg acgcccacag cctcgcgaag acaggcggac cactcgtggg cctcggccca
    15001 tggctcgacg ccttcgcaac cgccggccag gcgctcgccg acctcgcccg gcacggccgc
    15061 ctccgacggg ggctacgcgc cgtcatcgca caccacgtca tcttccacgc caaccgatct
    15121 ggcctgtccg ttcaggacca gtccaccctc gccgcgctcg cggtccgcaa cgtcttccac
    15181 cacaccacga ggagcaccgt gtcgatcgca gaacccacgc ccacgagcac tagcgtcgat
    15241 cgagtgacca gcgaccccgc cgacctgcgc gccgcactca ccgacgcact gcgcgccgag
    15301 aacatcatcc gcacgcccgg cgtcgaggcc gccatccgcg ccaccccgcg ccacctgttc
    15361 ctgcccggcg taccgctgga gcaggcctac gccgatgctc ccatctacac caagaccgac
    15421 ggccgaggcg cctccatcag cgccgcctca cagccacgaa tcgtggcaat gatgctcgaa
    15481 caactcgacg tacgacccgg ccaccgggtc atggaagccg gcgccggcac cggctacaac
    15541 gccgccctgc tcgccgccct caccggcgac aacggacgcg tcgtcaccct cgacgtcgac
    15601 gaggacctcg tcgacggggc ccgcaagcac ctggccacgg ccggcgtcac gaacgtggac
    15661 gtcatcctcg gcgacggagc gctcggctgc cccgacggcg caccctacga ccggatcatc
    15721 gccaccgtcg gcgcctacga aaccccgaca gcgtggctgg agcagctcgc cccgaatggg
    15781 cgactcgtcg taccgctgcg cctgcgtggc gccgcctccc gctcgatcat cctccagcgg
    15841 cacgacggcg gatggcgcga ccagggcagc gagctggccg tcttcatgcc gctgcgcggc
    15901 atcggcgacg acgcccgccg gcaggtaccg atcacaccgg agcaggacgt gatcctccag
    15961 gtgcacaagg aacaggacgt cgacgccgcg gcactggccg gcgtgcttca caccgagcgg
    16021 cgcaagatct ggacagacgt gttcttccca ccgatggtgc cctacgagtg gatggacctc
    16081 tggctggcct gccgcctcga caacgccatc atgcgcatga acgtccaacc cgcagccatc
    16141 gaacgcggca ccgtcacccc gatgttcccc tggggcgcga tggccaccac ccgcggcgcc
    16201 gacctcgcct acctcaccat caggcccacc ccgaccagac ccgacggcac cagactgtac
    16261 gaggtcggcg tcatcggtca tggcccggac ggcgccgacc tcgcacacca ggtcagcgag
    16321 gagatccgca cctggaacgc cacctaccgc tcccggaacg tccgcttcga aatccccgac
    16381 gctcccgccg aggcggaccc gtcggtcgga cgcttcgtcc ttccgcggcc gcaccacccg
    16441 ctcaccgtca tctggcagtg accgtggagc tggacagcgc ggtgctgcgg cgcttcccgc
    16501 tggtcgcgcg gccacggccc atcgctgggc cgctggttga gcgggtcgac aatctgtgcg
    16561 cactggccga acgcgccgtg cgagagcacg accgagctgc ggcgtcggcc gcctacaacc
    16621 aggctgctct gctcgcgtca gactgcggcc agccggacct ggcccgcagg tggtgccacg
    16681 agcacgccga cgcgtacctg caagccgtac ctctggacgc gcgggcggcg cggtatgcgc
    16741 tggagccctt ggtcaacctc gcccggctgc acgttcgcga ccgcgacggc gacgccgctc
    16801 tttgcctcct cacgagcctc ttcgaggcgg tgtcgtcacg gacggacacg gtgatcgacg
    16861 gccaggcgct gccggcgagt cagctgactc gcagcgagga cgaacaccat gaggtgaagc
    16921 agtggctgtg gagcgtgctc gtggcggagg gcgcccgtgc gctggctggt gccggccggt
    16981 ggagcgaggc gtacgcgcac cttgagcggc accgtggcat cggccagcgg atgctcgacg
    17041 gacgtcaggt ggcggtcatt gcccatgtca cggcgggtga tccggagtcg gcccgggcgc
    17101 tggtggccgg aaccgctcgg ggtgagccgt gggaggaggt ggtcaccggc tgcttggccc
    17161 acctgtgcga caggtcttcg cgtgcgaact tggacctcgc gttggagggc tacctcggtc
    17221 tacggccggc gcagggccta gctgtcttcg aaactcggct gggcttgacg ctcgttgacg
    17281 cgtcgaccgg agcggatcag cgaatcttgc ccaagcttgt ttcggaagtg gttgccagag
    17341 cggtcggctc cggtgacgcc tgcgctgccc gcgaagttct cctccacgaa ggtctcatgg
    17401 cggcccttga cggctggcac accacccaac tcaggaccac cgtatcggcc agcgggttga
    17461 tcttggtctc acttccggtc tggtcgcggg aacgcatcga cggcgtcctc ggcgcttgtc
    17521 gcgctgcgat cgctgaggcc tggtgagcgc ctcgaatcga gcgcctgcga tcaacgaacc
    17581 ggattccttg cgacccctcc agggatgatg gcgaccgccg tgcccatgga cggcgggctg
    17641 aacgtcaata tcgcgttgcg atcccttcag ggtgatgagc aacgctgggc tagcctgctc
    17701 tccgggtgcc ggctcctgtt ggggtcattc cagaggtgac gagcgacggc gtaccagccc
    17761 ggcttggagc gcaagaccct tgatccgtac ttggcgggtt ggcgcaagcg ggtggtaccg
    17821 acgctcggtc acattcccgt tcggatgatt accaatggcg cggtggatcg ggcggtgcac
    17881 tcgtggatcg ccgacgagta cagccgatcg acggtgaaga acagtctcgc cgtgctggtc
    17941 cgggtgatgg aacaggcggt acgggacggc atcatccagc ggaatcccgc ccaggtgacc
    18001 ggttggcagc gcgagtacca gcgggccgcc gacgagctgg acgatcctcg ctcactggca
    18061 ccgcccgatt gggaaacgct gaccactctt gccgctgcac tggtcgaccg ctccgcgaat
    18121 cacttcaccg gatgggccga cgtggtgata ttcgccgcct gtaccgccgc ccggatcggc
    18181 gaggtttccg gcgtccgcgc cgaggacatc gaccgggaaa cgtggatgtg gacggtccgt
    18241 cgccaaacca cgcccggtcc cggtggtctc attgacaagg gcaccaaggg aaagcgcgcc
    18301 gcgcggtgcc gctgattgag gaggtccggc cgatcgtggc tcaccgcctg gacgtcgcga
    18361 ccaagcccga ctcccggctg ttcaccgggc cacgcggtgg ccgggtcagc accgccgtac
    18421 tacgcgacgc gacgcattgg gatgaggtcg ttaccgcact cggatacgaa cacctacgcc
    18481 gccacgacct gcggcacacc ggccttacct ggatggccga cgcaggcgtg ccggtacacg
    18541 tcctaagaaa gatcgccgga cacgggtcac tgaccacaac ccagcggtac ctacatccgg
    18601 accaacggtc aatcagagaa gcgggtatag cgctcagcgc ccatctcaag gtccatcggt
    18661 tcccgaaacc attcgaatca cgcgccgttt agtaatgacg attggctgtg cggagcgtcc
    18721 ggacgctccg cacagccgag cagcctcagc gaagctcgta ggaccggatg agatgagggc
    18781 gctcgctcag tagcgcttcc aggcgcgcat cgttccacac ttcaatactg ggtcgaccgc
    18841 ctcgcgcatt gtgccgctca atccacgcaa cagcatcagt cgtaaagcgc ccgctggtcg
    18901 caatcacaag tacatcgaac ggaggatcct gccagtgccc gatactcaca attgctgaac
    18961 taacatcgac atcacgaacg ggccgcgaga gccagtgctt gcactgaatc gctacccttt
    19021 gtgagctgtg accacttaga ggatctcgtc gcaggcgcgt tgcacttacg tctcgaccgt
    19081 ggtcaggggc gttggtgtgc attagccagt cgacgttctc ataaccatcc gtctcgacta
    19141 ccagctgaaa aattagccgc tcaaaagctc cagagtcaac attcgaccaa gcaagttcta
    19201 agccaggacg cctgaccgga aggtcgatcg gcgagtacgc cattggatca tcgagatcta
    19261 gcgaccgcac aaaaaggagg tgagacagag tggacagggg aaggcgtgaa tctctccggt
    19321 aaacggaaac ctgccaccct tgagcatacg cccggtcaac atcggccgag attctcgtta
    19381 ccgcactatt ggctgcttgc ttcgcaggca ctttctctct cacgcggtag gccgcgcttt
    19441 ctttcgctgc ccgccagata aagtagaaca cttggccgat tgaataccac ttaagagccc
    19501 ggcggaacac gtcgtccgtt ttctgtcctg gcgcaaactc caagccgtga cgcttaagca
    19561 tgttaacgag gtatgccttg cactccgcga cggcaacgtc cagccagaaa ctcgggaact
    19621 gttcgaccca gcgatccggc cacgagctac gcgaagaaat cttcccgaaa ctcttaaggt
    19681 agtcgtccac acgatcatct agggaccccc taccagtcag gtagtaggca ccgtgcgtgg
    19741 gatagaagga atcactaagg ctgccgtcgt cgttccagac aaacgattcg ggcgacgagg
    19801 aaggatgtaa ctgcaccagc cccgagtctc gcaataggct gagcaacttt acatcgtact
    19861 cagtagttgg ggtgaaacgg tcagtgcgtt gcgcaattgg tgcggtcact ccgcgagaca
    19921 actcttccgc atcttccagc aaggcagcca acgcgaaagc ctcctgcatg tcgagatcct
    19981 cggcacgagg ggtcgactcg tcctccacta caggaaagtg atcacgtatg actgccgccc
    20041 tcgcggcatc tgctcgtttg cgctgttcag cctgccgctg ctgttcagcc tccacgcatg
    20101 tctgacatcg gcgatcgacg taccgagcac tggacgtcca ttgcgcccgg gaccggaaaa
    20161 tgaagccttc gccacattcg ctacagcaaa gctcggccga gcgggcatag caagcctcgg
    20221 acacaacctt gctgaccttg tacgaagggt agccaaaggt gtcagcaaga tccttcacag
    20281 cgtgggcaaa cgagccgtct tcgcgcgttg cccagtacgc cgagcagatt tcactcagat
    20341 gctgatgctc tggatcgatc tcaacctcga accccggcac aagccctcca ccccgctggg
    20401 gcttccgttt ggcccttcgg ggccagcaac ggtcccagac ggtccccagc ctcgaccgag
    20461 ggcaggccca cggcttagcg agaacctgcc gctgacctgc ggctacatac cgtcgggacg
    20521 gccggattcg aaccgacgac cccttgaccc ccagtcaagt gcgctaccaa gctgcgccac
    20581 gtcccgatgc ccccgccggg tctcccctgc ggcagccggt acagcttagc gcaggatctt
    20641 cgcaccgtgc gcagaggccc ctcccgcgcc gcgcgccaca ccccctagag catcctagga
    20701 gggtgtggcg cgacaacacc aagagcgcca agtagagcgt cagccgtggg ccttgccccg
    20761 gccgccgggg ccgagcttct tgcgcgggcg taccgagatc tcgatcgggc tgccctcgaa
    20821 gccgaactcc tcgcggagct tgcgctcgac gaagcgctgg tagccagcgt cgagcgggcc
    20881 ggtggtgaac agcacgaagc gcggcggcgc cgccccggcc tgggtggcga acaggatgcg
    20941 cggggcgcgt ccgccgcgta ccgggtgcgg ggtggcctgg accagcgcgg tgagccactg
    21001 gttgagctgc gcggtcggga tgcgcgtctc ccagctcgcg agggccttgc gcagcgcggg
    21061 tgcgagcttg tcgacggcgc ggccggtctt ggcagacagg ttcagccgga tcgcccaggg
    21121 gatgcgccgc agctcgcggt cgatctcctt gtccaggtag tagcggcggt cgccgtcgac
    21181 caggtcccac ttgttgaacg cgatgaccag cgcccggccg gactcgacca ccatggtgag
    21241 gatccgctgg tcctgctcgc tgatcacctc gctggagtcg atcagcacca cggcgacctc
    21301 ggccgcctcg atcgccgagg cggtacgcag gctggcgtag tactcggtgc cgctggcctt
    21361 gccgacgcgc ttgcgcagac cggcggtgtc gaccagctgc caggtctcgc cgccgatctc
    21421 gaccaggctg tcgaccgggt ccactgtggt gccggcgacc gagtcgacca ccgcccgctc
    21481 ctcgccggag aagcggttga gcaggctgga cttgccgacg ttggggcggc cgaccagcgc
    21541 cacccggcgt gggccgcgcg gccggttctc cacgatcgcg ggcgcctcgg gcagcgcgtc
    21601 gaggatggcg tcgagcaggt cgccggagcc gcggccgtgc agcgccgaga tcgggaacgg
    21661 ctcaccgagg ccgagcgacc acagcgaggt cgcctccatc tcgatggtgg tgttgtcggc
    21721 cttgttggcg atgaggatca ccggcttggc gctgcggcgc agcatcttca ccgcggcctc
    21781 gtccacgtcg gtggcgccga ccatggcgtc caccacgaac agcaccacgt cggcggtcgc
    21841 caccgcggtc tcggcctggg cggcgatggc cgcggcccgg tccttggcgt cgggctccca
    21901 gccgccggtg tccaccaccg tgaacgcccg gccgttccac tgcgcgtcgt agggcacgcg
    21961 gtcccgggtc acgccgggga tgtcctccac gaccgcctgc cggcggccga tgatgcggtt
    22021 gacgagcgtg gacttgccca cgttggggcg gccgaccacg gccaccacgg gctgcgggcc
    22081 ggccggctca ccggagtcga cctccggctc gcgcagctcc acccagcctt cgaaatcctg
    22141 gctcacgcgg caccccgctc cgtgagcatc tcgcgcaggc gggccactac ctcgtcgatg
    22201 cccagctcgg tggtgtccag caccaccgcg tcgggggcct gctgcagcgg gttgaccttg
    22261 cgggtcgagt cgaggcggtc ccggcgggcc aggtccgcgg cggtcgccgc gacgtcggcg
    22321 gcgtcctcgg cgctgcgccg cttcgcgcgc gccgcctcgg aggcggtcag gtacaccttc
    22381 agctccgcgt ccggtgcgac caccgagccg atgtcccggc cttcgaccac gatccggccc
    22441 gcgtcggcga tcacccgccg ctgccggtcc accagcagct cgcgtacggc ggcgacggcg
    22501 gccaccgcgg acacggcggc ggtcacctcg gcgccgcgga tggcggtgga cacgtcggtg
    22561 ccgtcgaccg tcacggcgta cccctggggg tcggtgccga tgcgcaggtc ggcctcggcg
    22621 gcgaccttgg ccaccgactc ggtgtcggtg agttccacgc cggagcgcag gactgcccag
    22681 gtcagcgccc ggtacatggc gccggtgtcg aggtagcggg cgccgaggcc cgcggccagc
    22741 cgccgcgaca cggtggactt ccccgaaccg gacggcccgt ccacagcgac cacacatcgc
    22801 ccggccggta cgttctcctc caccgttgtc ctcctcagcc cgtacctcgc gggtcgcccg
    22861 gattcccggg cgccgttgag cggatggttc tgtcgtcaat catgcccgcg ccgcgcgggc
    22921 gtcccgccgg gcggcacgcg ccggcccgcg gaccgcgtcg aagcctaccg gcagccgtac
    22981 cccgatcggc gggtcagtca cccacggcct tgaacagggc ggcgacctcc gcgttcgtca
    23041 gccgccgcag ccgcccggtg cgcaggtcgc cgagcttgat cggaccgatc gaggtacgga
    23101 tcaggcggga caccgggtgt cccacctcgg ccatcaggcg ccggacgatg tgtttgcgcc
    23161 cctcgtgcag ggtcagctcc acctgggcgg ttttgccgag cgtgtcgacc agcttgaacc
    23221 cgtcgacctt caccggcccg tcctccagct cgacgccggc ggcgaggcgc ttgcccaggt
    23281 tgcgcgggat cggcccggcc acctcggcga ggtaggtctt gagcacctcg tacgacgggt
    23341 gcatgagctt gtgcgcgagg gtgccgtcgt tggtgagcag gagcaggccc tcgctgtcgg
    23401 cgtccagtcg cccgacgtgg tagacccgct gctccagccg cgcgccgatg aagtcggcca
    23461 gctcggtgcg gcccttctcg tcagccatgg tggtgaccac gccgcgcggc ttgttcatcg
    23521 ccacgtagac caggcggacg tcggcctgga gccgctcccc gtcgacgacg atcacgtcgc
    23581 gggccgggtc ggccttgtcg ccgagctgcg ccacccgccc gttcacggtg acccggcgcc
    23641 ggaagatcag gtcttcacag gcgcgccggg aacccacccc cgcggcggcg agcaccttct
    23701 gcaggcgctc ggcgccctcg tacacggggg cgtcgggctt cggggcacgg tcatcgcgtc
    23761 gcatcggcaa gctcttctac gtcgtcggga aggaacgggg ccagcggcgg caggtcgtcc
    23821 accgagttca gccccagctt ctccaggaac atggtggtgg tccggtagag gtaggcgccg
    23881 ctgtccgctt cggtgccgca ctcctcgacc aggccgcgac ccaccagggt acggagcacc
    23941 ccgtcgcagt tgacaccccg gatggccgag atgcgcgaac gggtcaccgg ctgccggtag
    24001 gcgaccacgg cgagggtctc cagcgcggcc tgggtcagcc gcacggactg cccgtccagt
    24061 acgaaccgct cgacgtaggt ggcgtattcc ggccgggtgt agagacgcca gccacccgcc
    24121 gcccggcgca ggtcgaaccc gtgcccggcg gcggtgtatc cggcggcgat ctcgtcgagc
    24181 atcgcgccga cccgttccgg ggactgctcc aggacctcgg ccaggaccag ctcgctgacc
    24241 ggctggtcca ccacgagcag gatcgcctcc agggcgccgc gcagctccgc gtcgtccagg
    24301 accggcgcgg gcaccggttc cggcgcggcc cgccgccgtc cccgcttggc gggtacgccc
    24361 tcagcacccg ctcccccacc cgcccccggc gccgcgtccc gcgcgggcag gccgacgtct
    24421 cccccggcgt cgtccgtccc ggcctctccc gagattttgg tacggtcccg ccctccgagg
    24481 ggcgtccccg taccaagatc cccctgaacc gtggcgatct tggaaggaat gggcccctct
    24541 gagggccctt cgcttccaag atccgccgag gaatccggtg tcgcgtcgag atctgcttcc
    24601 cgggaatcgg tggtgtccgg gatgtcgggg tccgggtgct cggccggtgc gtcggaatcg
    24661 tccggggctg gccggggcgg ggcgggacgc tcccacgggg gcacccatgc ggcggcctgg
    24721 tcggccaggg agtcgcggcg ttcctggtcg ctcatccgtt cactcctgcg tcggtgcgtg
    24781 ttcgtccgcc gtctcgctgg gcactgcggc gtcggatgcg gcatctgcgg cgacgtcgcc
    24841 cggcacggcg gcgtcgctca ccccggcgcc gacgtcggcc ggagcagccg cggcgtcggc
    24901 cggtgcggcg gggacggacg tggtcgtggg ttcggggctg ccggcgtact cgtcgacggt
    24961 cagctcggcc tcgccgtcga ccgggccggt ccagcgaacg gtcagctcct ccagcgcctg
    25021 ctcctgcacg aacgccacga ggccctgccg gtacagctcc agcagcgcca ggaaccgggc
    25081 caccacctcg agcgtcatct cacagtctgc gcagagcagc gagaacgtgg cgatcccggc
    25141 gcggcgcagc cggtcggcga tgatgccggc gtgttcgcgg acgctgaccc ggaccatgtg
    25201 cacgtgcgcg atggacacct cgggcaccgg tttcgggctc atcgccttga ccgcgagctt
    25261 gcgcagccgc tcgggaccga tgccgagcac caggtcgggc agcgcctcgg cgtaccgggg
    25321 ttcgagcgtg accgccctcg ggtagcgccg tccgccgacc gcctccagct cggcgatgtg
    25381 cgcggcggcc tccttgtacg ccttgtactg cagcagccgc gcgaacagca ggtcccgcgc
    25441 ctccagcagc gccaggtcct cctcgtcctc cacctcggcg gagggcagca gccgggccgc
    25501 cttgaggtcg agcagggtgg cggcgacgag caggaactcg ctggtctcgt ccaggtccca
    25561 ctggtcgccc atcgcccgca ggtacgcgat gaactcgtcg gtgaccttgt gcagcgccac
    25621 ctcggtgacg tccagcttgt gcttgctgat cagctggagc agcaggtcga acgggccggt
    25681 gaagttgtcc agccggacgg tgaagccact ggcctgctcg ccggtgcccg cgtcggcggg
    25741 caccacaccg tcgacctcgg cggccagctc cgcggctacg gcggggtcgc cggcgccgtg
    25801 tggcgggtcg aggggcggtg cggtcaccgg gaaaccgtag acgacgcggc gggcggccgg
    25861 cgtgcgccct accggtccgc ctgggcggcg atgacctccc gggccagctg ccggtagttg
    25921 cgggcgccgg aggaggccgg gtcgagggtg gtgatcgggg cgccggccac ggtggactcg
    25981 gggaacttca ccgtcttggt gatgacggtc tggtagacct tgtcgccgaa cgcctcgacc
    26041 acccgctgca gcacctggcg gcagtgggtg gtgcggctgt cgtacatggt ggcgaggatg
    26101 ccttcgagct ccaggtcgaa gttgagccgc tcgcgcacct tgtcgatggt gtccagcagc
    26161 agcgcgacac cgcgcaggct gaagaactcg cactccagcg ggatgagcac gccgtgcgcg
    26221 acggtgagcg cgttgatcgc cagcaggccc agtgagggct ggcagtcgat caggatgaag
    26281 tcgtactcct tgcggatggt gcgcagcacc cgcgccaggg ccatctcccg ggcgacctcg
    26341 ttgacgagct ggatctcggc ggcggagagg tcgatgttgg cgggtagcag gtgcagcccg
    26401 gccacgtcgg tcttgatcag gacgtcctcg gcgatgacgt cgtcctgcat cagcaggttg
    26461 t
//
