LOCUS       NZ_BBVA01000002        21044 bp    DNA     linear   CON 10-SEP-2024
DEFINITION  Micromonospora sp. NBRC 110037, whole genome shotgun sequence.
ACCESSION   NZ_BBVA01000002
VERSION     NZ_BBVA01000002.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Micromonospora sp. NBRC 110037
  ORGANISM  Micromonospora sp. NBRC 110037
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Igarashi,Y., Komaki,H., Ichikawa,N., Hosoyama,A. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Micromonospora sp. NBRC 110037
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2438518)
  AUTHORS   Hosoyama,A., Ichikawa,N., Kimura,A., Ohshita,R. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 106x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001652995.1-RS_2024_09_10
            Annotation Date                   :: 09/10/2024 02:06:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,195
            CDSs (total)                      :: 6,136
            Genes (coding)                    :: 6,073
            CDSs (with protein)               :: 6,073
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 15 of 63
            Pseudo Genes (incomplete)         :: 53 of 63
            Pseudo Genes (internal stop)      :: 4 of 63
            Pseudo Genes (multiple problems)  :: 9 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2121011
            Orig. end                         :: 2142055
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBVA01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21044
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="13"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21044
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21044
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11044](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11044
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(682..1509)
                     /locus_tag="A4R25_RS08775"
     CDS             complement(682..1509)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018789272.1"
                     /locus_tag="A4R25_RS08775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PIG-L family deacetylase"
                     /protein_id="WP_064446252.1"
                     /sec_met_domain="PIG-L (E-value: 2e-29, bitscore: 99.8,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRSLTLMAVHAHPDDEATSTGGILARYAAEGVTTVLVTCTDGG
                     CGDGPGGTKPGDPGHDPKAVVEMRRAELAASCEALKVTHLETLDYGDSGMMGWATNDAP
                     GAFWNTPVAEAAGRLAELIRRYRPDVVVTYDENGFYGHPDHIQAHRITMAAVEQTGIPA
                     KVYWTTVPRSAFQQFGTVMREIGVEFPEPEATDEMPALGLPDDEITTWVNTSGYGGQKF
                     ASLAAHASQAENIFFLRLGQERFTELMGMETFVRVRDTTGAPTPEDDLFAGLR"
     gene            1583..2296
                     /locus_tag="A4R25_RS08780"
     CDS             1583..2296
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285854.1"
                     /locus_tag="A4R25_RS08780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_043324727.1"
                     /transl_table=11
                     /translation="MGWLQRLLGGGRVELDPTRQQELLRDVRQSYGAHARLRFPEQADA
                     ITRLLSDDDGLVVAAGIVCEAADQAHADLLGQAHEVFRRTGRRLLVHRRNYRPLWKEAG
                     PALRWPLGALPSGLHPYAQVAGAVAAVGGRADRLDKVTDPQPFVTRLFEVLDLTTAGWE
                     FGRVRVDTDSASLVERLMGTGARVLATMDDPPRLPPAVREMMRRNHRIAVYDPAGPRVV
                     GEFNLGARLRETLLA"
     gene            complement(2349..5159)
                     /locus_tag="A4R25_RS08785"
     CDS             complement(2349..5159)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477134.1"
                     /locus_tag="A4R25_RS08785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase N-terminal domain-containing
                     protein"
                     /protein_id="WP_064446253.1"
                     /transl_table=11
                     /translation="MSEVTRRNVIKAAAAGTGAALVPAAWSAAARAGSAAPAQVLAAND
                     LALWYDEPAGTDWLRALPIGNGRLGAMVFGNVDTERLQLNEDTVWAGGPYDSANTRGAA
                     NLAEIRRRVFADQWTSAQDLINQTMMGSPGGQLAYQTVGDLRLSFGSASGATQYNRTLD
                     LTTATVTTTYVLNGVRYQREVFASAPDQVIVLRLTADRANAITFSAAFDSPQRTTVSSP
                     DGATVALDGISGSMEGVNGSVRFLALANAAVTGGTVSSSGGTLRVSGATSVTVLISIGT
                     SYVNYRTVNGDYQGIARNRLNAAKSVDVDQLRTRHRADYQALFDRVTIDLGRTAAADQP
                     TDVRIAQHASTNDPQFAALLFQFGRYLLISSSRPGTQPANLQGIWNDSLTPSWDSKYTV
                     NANLPMNYWPADTTNLSECFLPVFDMVKDLTVTGARVAQAQYGAGGWVTHHNTDAWRGA
                     SVVDGAFWGMWQTGGAWLSTLIWDHYLFTGDLGFLQANYPALKGAAQFFLDTLVAHPTL
                     GYLVTNPSNSPELAHHANASVCAGPTMDNQILRDLFDAAARASEVLGVDTTFRSQVRTA
                     KDRLPPSRVGSRGNVQEWLADWVETERTHRHVSHLYGLHPGNQITRRGTPALYEAARKT
                     LELRGDDGTGWSLAWKINFWARLEDGARAHKLLRDLVRTDRLAPNMFDLHPPFQIDGNF
                     GATSGIAEMLLHSHTGELHLLPALPSAWPAGQVAGLRGRGGYTVALTWSNSQADEISVR
                     ADRDGTLRLRSRLFTGAFTLTDVTDGSTPATTRPESDVVALTVRAGHTYRAVRPGVTPS
                     PTVTTTPTSTPSPTPTPTTSSPAPSGARATYAITGSWSGGFQAEVTVTAGATAIRGWTV
                     SWTFPNGQVINQIWSGTHTQSGANVTVRNVDYNGSVPAGGSTTFGFIGTAGGTNNPPTN
                     LTCTTT"
     gene            complement(5316..6332)
                     /locus_tag="A4R25_RS08790"
     CDS             complement(5316..6332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018786879.1"
                     /locus_tag="A4R25_RS08790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_064446254.1"
                     /transl_table=11
                     /translation="MDLAAFRALEPLCWRAPSAHNTQPWRLRYERWAITVGWDPADTLP
                     AGDPTGRDLRLSLGAFVETCLIVAADAGLRLDWAADHDESDRRVGRLRPARQPYRTPFR
                     AADVWDRRTHRGRFTGGPDADVVAAVDAVARRAGGAARVVPAAGRLRALLRTADRHVYA
                     DPSVVAELRRWLRLDRACPRYRSDGLSDSCLGLGRAAATGLRAALAAYPALRPLGLPRL
                     LATAGGDPLAQGGGVLALIAPPGLDAAGQVEFGRVLMRMWLTLHTAGLAAHPLSQLVDV
                     AATRGALGTLLDVAPERIVHVARVGRPAAPAPRSARRVRHGSRLLAVTPLDAMSLHP"
     misc_feature    complement(5355..5357)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6335..7417)
                     /locus_tag="A4R25_RS08795"
     CDS             complement(6335..7417)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477140.1"
                     /locus_tag="A4R25_RS08795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_064446255.1"
                     /transl_table=11
                     /translation="MTGHRFERVTGRRGLRDFLALTDRLYADESRYVPTPRQQIRRWWR
                     DGVPMYVLRDATGAVVGRTTLHTDADLDAKLGRRCQLFGLTEFTPHAARPLFDAIATYA
                     TPGRDLLFGPVALLPNQAGGVITSGYADRGFVDSAWNPPYYPDAYEENGFTGRFVSDTW
                     ICPVPPPTGPPPALGVQPDGSRLDLHRGNSRRLDEQLGLLRGMLNDSFAQLGYYTPISA
                     AQLRRQTDGLAYLLDDSLLLYLTRDGHPVAFVLCVPDISDFLVAVRGDLNPVNQLRLLA
                     TRRRYRREAVLIVKGVVPRFQGRGYQRLLSEHLHRNLHEGGYTALRSTYVGRDNPASAA
                     QYRRLGGRPLHGYTFYARER"
     gene            complement(7414..7854)
                     /locus_tag="A4R25_RS08800"
     CDS             complement(7414..7854)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018786877.1"
                     /locus_tag="A4R25_RS08800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_064446256.1"
                     /transl_table=11
                     /translation="MRTRDFSRAPAQARAGAMFIGGTRYANPLVLLRLAPDWIRMVRDM
                     RRMSGYCWHTVYWQFPLTLGTIAFFTDRDALLRFARTRHHRKLMMWLTDGNRNATAGFI
                     RLYTASPDGYSNGAWRAEDGAMGHIERFTPLGAETTGPAVRR"
     gene            complement(7858..9420)
                     /locus_tag="A4R25_RS08805"
     CDS             complement(7858..9420)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285845.1"
                     /locus_tag="A4R25_RS08805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phenylacetate--CoA ligase family protein"
                     /protein_id="WP_064446257.1"
                     /transl_table=11
                     /translation="MAETLHRHAALRTVDTPLPAEAALAPAGRAVAALARLIAHHPAGW
                     RWLARRHHPVLDRLAAANARSTCVRAARRVPAYQAFLRARPGGLRRRLRDFPETDKRGY
                     VMAYDASARCRDGRMPERGVVVDESAGSSGRPFNWPRGERELRAVHRDIAGYTGLAFPM
                     RRPFVINAYSMGAWATGTTTGAAMARIATVKNTGPDLGKIVDTLREFGPGHDYLVTAYP
                     PFLKHLRDRLDAEDFPWSRYRIFASCGGEGMTEALRDYLEQRFVRVRSAYGASDLTIGI
                     GAETRFTVWLRRRLRTDAGLRAELLGRGEQRLPMVFQYNPFATYLETNERRELLCTVTG
                     PHVLQPRLRYNVGDEALLVPYRRIVELAHADPVRRAEFRTAVAEERMTLPLLLLFGRSD
                     STVSYLGANLYPQDVEYGLYTGNPYAAEINRFCLTLHEDAALETRPVIHVELRRPLDAA
                     ARAALADACRDGVRAHLTSVSRDFAQSLVEDPTAGDLRVELHEPDCGPFAAMQKIKNVY
                     LVR"
     gene            9583..9993
                     /locus_tag="A4R25_RS08810"
     CDS             9583..9993
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477142.1"
                     /locus_tag="A4R25_RS08810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_064446258.1"
                     /transl_table=11
                     /translation="MTDGKRERTNERFEKVAEETSESVTHAATVLEEELAAGLAGARRL
                     EEKLTESRRVDPEAFDELVARVRTDGHALIDTVVGQLKMADDQRGEVIRRYTSDAHDAL
                     DTVLNLARLAPEVANGLADRLASPAPKRPTDR"
     gene            10001..11044
                     /locus_tag="A4R25_RS08815"
     CDS             10001..11044
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285843.1"
                     /locus_tag="A4R25_RS08815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_064446259.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.8e-45, bitscore:
                     151.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPTAGVAGGHVERMLERYRGLALGALLDDVPDGGPRYLYDLVAE
                     YPRRWGKGLRAALCLATCRAFGGGDAVGLNAAVTVELFHNAFLIHDDIQDSSEQRRGGR
                     TLHAEYGVGVALNVGNMTNLLALRRLAANRAALGSGIAWRLFTETELMMRHSLEGQAIE
                     IGWIRDNVCDLDADDYYRMCLKKTSWYTCIYPCRTGVLVATGRENAVDVLDRYGWYLGA
                     AFQIQDDALNLTGDYARYGKEIAGDLWEGKRTLILIDFMRRCTPEERERLVRLLSRTRA
                     QRTDAEVRWLHGRLLAYDCVESARRSARDLALAARREGERALGAAADTEDGRFLLELTD
                     YVVERAR"
     gene            complement(11041..12012)
                     /locus_tag="A4R25_RS08820"
     CDS             complement(11041..12012)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285842.1"
                     /locus_tag="A4R25_RS08820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetylxylan esterase"
                     /protein_id="WP_064446260.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.5e-06, bitscore:
                     24.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLTDLDLAGCLAYRPELDVPADLDGFWARTLDGGGDPAAAVYEP
                     VDTGLTQIRTYAVTIPGFAGEPVRGWLHLPAGADGPLPCVVEYLGYGRGRGLPHEKLFW
                     AAAGFAHLIMDSRGQGWSAATGGTPDPHPYPAGTVPGFLTRGVADPAEHYYRRLITDAV
                     RFAEAARRHPAVDPARVAVTGFSQGGGLALAVGALCPDVAAVMPDVPFLCDIRRGVRVA
                     GPDSPYAEVVEYLALHRDRADQVFRTLSYLDAAVLAPRATAPALFSIALRDQVCPPSTC
                     FAAYHRYGGDKDVRVYEFNDHEGGEAAHQGEQLTWLRGILGG"
     gene            complement(12003..12692)
                     /locus_tag="A4R25_RS08825"
     CDS             complement(12003..12692)
                     /EC_number="5.1.3.9"
                     /GO_function="GO:0009385 - N-acylmannosamine-6-phosphate
                     2-epimerase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006051 - N-acetylmannosamine metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0019262 - N-acetylneuraminate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477145.1"
                     /locus_tag="A4R25_RS08825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="WP_064446261.1"
                     /transl_table=11
                     /translation="MNSLVDQLRHRLVVSCQAYPGEPMRDPDTMRRVALATARGGAAGI
                     RAQGLADIAAIRAAVDLPLIGLWKDGDDDVFITPTLEHALAVADAGAHVVALDGTSRPR
                     PDGRTLAETIAAVHERTGALVMADCSTFDEGIAAAAAGADLVGTTLSGYTAYTTKGDGP
                     DLDLVARLAAAVDVPVVAEGRIHTPEQAAQALRAGAWTVVVGTAITHPSTITGWFASAV
                     REAASCR"
     gene            complement(12689..13618)
                     /locus_tag="A4R25_RS08830"
     CDS             complement(12689..13618)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477146.1"
                     /locus_tag="A4R25_RS08830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ROK family protein"
                     /protein_id="WP_064446262.1"
                     /transl_table=11
                     /translation="MPEVSTTGLVAALDIGGTKTTAALVTAAGEVVGRHTAPTPGRSGA
                     AAVLDTAAGLVEKLRADAPDVVRALGVGSAGVIDSASGLVLSATDVLTGWAGTDLRGDL
                     ARCLGVPVTVVNDVHAHALGEARHGVAAGHDTVLYVAVGTGVGASFVLGDTVLAGAHSA
                     AGHAGHQPSAYAGTLPCTCGGRGHLEAIAAGPALTAEYVRRTGRPVADLRAVAALAAGG
                     DETARDVVRLGGTAVGSAVGGLVNVLDPAAVVIGGGVTGLGEPWWRALRDAVPAETLPA
                     LAGVPVLASTLGPDAPLLGAASLAWKVS"
     gene            complement(13621..14559)
                     /locus_tag="A4R25_RS08835"
     CDS             complement(13621..14559)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285839.1"
                     /locus_tag="A4R25_RS08835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_064446263.1"
                     /transl_table=11
                     /translation="MTTPAPRFAGVVPPAVTPLTEEGEVDVHSLERLVEWLLDAGVDGI
                     FALGSSGETVFLTDRQRDLALETIVKTAGGAVPVLAGCIEPTTRRVVERAEASTRLGAD
                     GLVVTAPFYAIVGPHEIERHFRAVAAAVELPLLAYDIPVCVHSKLSVDLLTRLAAEGVL
                     AGVKDSSGDDVAFRQLALAIAEHAPERDFSLLTGHEVVVDAMMLAGGSGSVPGLGNVDP
                     AGYVRLHRACLAGDWAAARREQDRLTRLFRIVDAADPATSAGATRGVGAFKTALSLLGV
                     IAGNAVSLPLRPLDDAETGRVRTQLELAGLL"
     gene            complement(14556..15623)
                     /locus_tag="A4R25_RS08840"
     CDS             complement(14556..15623)
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015440 - ABC-type peptide transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285838.1"
                     /locus_tag="A4R25_RS08840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_043324745.1"
                     /transl_table=11
                     /translation="MSATAEHRPIAELSDVHVVHAARGGGMFSREKVYALTGADLVIRA
                     GETVGIVGESGCGKSTLAKVLVGLQRPTAGTVSFAGKDVWSMTATERREHIGAGVGMIF
                     QDPATSLNRRMPVRDILRDPLDVHRRGTRQQREQRVTELMALVGLPRSVADVLPSQLSG
                     GQRQRVSIARALALEPGLVIADEPTSALDVSVRAQILNLLLDLKDRLGLAMVLVSHDIQ
                     TVKRVSDRVVTMYLGRIVEQTPADLLPEGGRHPYTRALFSATPGLLSPIEPIPLVGPVP
                     SATRPPSGCPFRTRCWAATDGCAVDMPAPRPAEGAGHEFRCHHPVPAGTANTELVALAT
                     SATGRTTTESVEENL"
     gene            complement(15620..17578)
                     /locus_tag="A4R25_RS08845"
     CDS             complement(15620..17578)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285837.1"
                     /locus_tag="A4R25_RS08845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dipeptide/oligopeptide/nickel ABC transporter
                     permease/ATP-binding protein"
                     /protein_id="WP_064446264.1"
                     /transl_table=11
                     /translation="MRRSLTTRLSRPGMAFARLGLAARFALGFVALIVVVGVLAPLLLR
                     HDPTQTGLGPALTGPNGDFWFGLDKLGRDVFSRLVAGTRRSLIVGFGAAGIALVLGAIL
                     GALAGSSRTVVDEVVMRCLDVVMAFPTIVLSALLIISFGKNSLLVLVIAIGFVFTPSVA
                     RIVRANVLSQYGEDYVAAERIIGARRPHILWRHVLRNCAAPILVFVTVMVADAIVFEAS
                     LSFIGGGLAPQEAASSWGSVIAFGKEMVQIGGWWATFFPGLLILLTVLALNVLSEGMSD
                     AWAAPAARRATSTTSGDALEQAQPGTGEVVELPGLAEAAQRLRERARPLPQGKPVLQVS
                     DLSIGFEGRHRGVDIVDGLTFDVRPGEVVGLVGESGSGKSLSVLAVMGLLPQGARVRGE
                     IRFQDTDLLKLNAKGRRALMGREIAMVYQDALSALNPALRVGAQLAQMIRRGGTRSAEE
                     LMRLVGLDPRRTLAAYPHELSGGQRQRVVIAMALSRDPKLIIADEPTTALDVTVQAQVM
                     ALLLELRERLGFALILVSHDLALVSDVCDRVVVMYGGQIVETGVTADVMEAPAHHYARG
                     LLGSVLSLETGAERLTQIRGVVPSPADFPKGCRFSDRCPMATEICRDTAPTMAGTDGHG
                     YACHHPAVTVSEKEPAR"
     gene            complement(17578..18534)
                     /locus_tag="A4R25_RS08850"
     CDS             complement(17578..18534)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285836.1"
                     /locus_tag="A4R25_RS08850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_064446265.1"
                     /transl_table=11
                     /translation="MLTVLNLVARRFLTLIPLVLGITLFVFVIMQFSPIDPALSVLGDQ
                     ATPAQVEAFRAANGLNDPLPLRYLHFLGDLVRGDLGMTFPPSVPVAEKIAMALPLTIQL
                     TALGVVGALVIALALGIPAALYRDRWPDQVIRIVSMAGIATPSFWLALLFIQEFSVRRP
                     IFPTGGYVNPADSVGLWLQSLALPALALAVPVGCSLARIVRTSMVEELDKDYVRTAVGA
                     GLPPRVVIGRNVLRNALVNPLTALGLRIGYLIGGTVVIEAIFSLPGMGTQIMSAVQQND
                     TALAQGTVLTIALCFVLVNLVVDILYLFANPRLRGGH"
     gene            complement(18636..20258)
                     /locus_tag="A4R25_RS08855"
     CDS             complement(18636..20258)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285835.1"
                     /locus_tag="A4R25_RS08855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_043324748.1"
                     /transl_table=11
                     /translation="MSTTGKSRSWRVPRRRVRPLAVASLGATLALGLVACSGGPASTNA
                     VSGGKAGTSIEATLAFTLSSGFDPGNASSAVATAVNQHVFEGLVDLDPITREPYNALAK
                     SDPTPGADGLTYTVTLRDGAKFSDGTPVTAEDVAWSFTRVLKPADPKAPPLMQGFVSFL
                     DSVTAKDAATVEFKLKYPFALFSERISVIKVVPKAKTGDAAAAKAFDTAPIGSGPFKVD
                     SASKESGIKLSKNETYNGPRPAKVETMTWNTTTEASARVSDLQGGRVQAIEAVPYLNVD
                     SLKDKYTIDVKQAFNQVFLMFNNAAAPFSDKRVRQALHYAIDKDAVIKTALNGYGSPAT
                     SYLDEGNKAYQKAATVYDYNPDKAKALLQEAGVTNLSFRLDTTDNSVVKDVAPLVIEQW
                     KKIGVNATLNTVPSSAIYGDIVPKDTFRVLMATGDPSVFGVDTDLLMRWYYFGETWPGQ
                     RYRWSDANRKAMGDLLDKAAQTSDEAARKALWKQALDMVADDAPLYPILHTKVVTAYDP
                     AKLDGFSGASTTGLYFLGTGRTG"
ORIGIN
        1 ccaccaactc gccgctgcac gacgggcggg acaccgggca cgccagctgg cgctcgatgc
       61 agttggaacg gtggccgagc atcgggccga cgccgcactt ccactcggcc gccgactacg
      121 acgccacggt ccgggacctg atcaccgccg gcatcatgct cgacgccgcg atggtctact
      181 ggtacgcccg cccgtcggcg gcgtacccca cagtggagat ccgcgtcggc gacgtctgcc
      241 ccacagtcga cgacaccgtc ctgatcgccg ggctggtccg ggcgctcgtc gccaccgcga
      301 tcgacgacat tcgcgacggc gtgccggccc agcgcatccg cgactgtctc gtcgccgccg
      361 cgcactggcg ggccgcgcac gacggcgtgg acggtgacct ggtcgatctg cgtaccgggc
      421 ggccccggcc cgcctgggac ctcgtcgacg acatgctcgg cttcgtcacg cccgcgctga
      481 cccgccacgg cgacttggac ctggtccggc gcgagatcga ccgggtgcgc cgcgagggca
      541 ccggcgccac ccggcaacgt caggtcatgg ccgacaccgg cggtgacgtc cgtgtcgtgc
      601 tcgcgcacct ggccgcgcag accgtcgcgg cctgagatga gcggcccggc cgacgacacg
      661 ccggaccggg ccggcggccg gtcagcgcag cccggcgaac aggtcgtcct ccggcgtcgg
      721 cgcgccggtg gtgtcccgca cccgcacgaa cgtctccatg cccatcagct cggtgaaccg
      781 ctcctgcccg aggcgcagga agaagatgtt ctccgcctgg ctggcgtgcg cggcgagcga
      841 cgcgaacttc tgcccgccgt agccgctggt gttgacccag gtggtgatct cgtcgtccgg
      901 caggcccagc gccggcatct cgtcggtcgc ctccggctcg gggaactcca ccccgatctc
      961 gcgcatgacg gtgccgaact gctggaacgc gctgcgcggc acggtggtcc agtagacctt
     1021 ggccgggatg ccggtctgct cgacggcggc catggtgatg cggtgggcct ggatgtggtc
     1081 cgggtggccg tagaagccgt tctcgtcgta ggtgacgacg acgtcgggac ggtagcgccg
     1141 gatcagctcg gccagccggc cggccgcctc ggccaccggc gtgttccaga acgcgccggg
     1201 cgcgtcgttc gtggcccagc ccatcatccc ggagtcgccg tagtcgagcg tctccaggtg
     1261 ggtcaccttg agcgcctcgc agctcgcggc cagctcggcg cggcgcatct cgaccacggc
     1321 cttcgggtcg tgcccggggt cgcccggctt ggttccgccg gggccgtcgc cgcacccccc
     1381 gtcggtgcag gtaacgagca cagtggtcac gccctcggcc gcgtagcgcg ccaggatgcc
     1441 gccggtgctc gtcgcctcgt cgtcggggtg cgcgtgcacc gccatcaggg tcagggatcg
     1501 atcggtcacc ccgtcaccat acgagcatcg gccgacgaac tagcattgcc cggtccgcag
     1561 acggcgacgg aagcgaggcg cgatgggttg gctccagcgg ttgctcggtg gcggacgggt
     1621 cgaactggac ccgacacgtc agcaggagct gctgcgggac gtgcggcagt cctacggggc
     1681 gcacgcccgc ctccggttcc cggagcaggc cgacgcgatc acccggctgc tgtccgatga
     1741 cgacggtctc gtggtggccg ccgggatcgt ctgcgaggcc gccgaccagg cgcacgccga
     1801 cctgctgggc caggcgcacg aggtgttccg gcgtaccggc cggcggctgc tggtgcaccg
     1861 ccgcaactac cggcccctgt ggaaggaggc cgggcccgcg ctgcgctggc cgctcggcgc
     1921 gctgcccagc gggctgcacc cgtacgcgca ggtggccggc gccgtggcgg cggtcggcgg
     1981 gcgggccgac cggctggaca aggtgaccga tccgcagccg ttcgtgacgc gcctgttcga
     2041 ggtgctcgac ctgaccacgg ccggctggga gttcggccgg gtgcgtgtgg acaccgacag
     2101 cgcgtcgctg gtggagcggc tgatgggcac cggcgcgcgg gtgctcgcga cgatggacga
     2161 cccgccccgg ctgccgccgg cggtgcggga gatgatgcgc cgcaaccacc gcatcgccgt
     2221 gtacgacccg gccggtcccc gggtggtcgg cgagttcaat ctgggcgcgc ggctgcgcga
     2281 gacgctgctg gcctgaccgt cggcacgccc cgccccggcc gggttgccgc ggcggggcgc
     2341 gtcagcggtc aggtggtggt gcaggtgagg ttcgtcggcg ggttgttggt gccgccggcc
     2401 gtgccgatga agccgaacgt ggtggagccg cccgccggca ccgagccgtt gtagtcgacg
     2461 ttgcgcaccg tgacgttcgc gccgctctgg gtgtgcgtgc cactccagat ctggttgatc
     2521 acctgaccgt tcgggaacgt ccaggacacc gtccagccgc ggatcgcggt ggcgccggcg
     2581 gtcaccgtga cctcggcctg gaagccgccg gaccaggagc cggtgatcgc gtacgtggca
     2641 cgcgcgccgg acggcgccgg ggaactggtg gtcggggtcg gggtcggtga cggcgtggac
     2701 gtcggcgtcg ttgtcactgt cggcgagggg gtcacgcccg gccggaccgc gcggtaggtg
     2761 tggccggcgc ggacggtgag cgccacgacg tcggactccg gccgggtggt ggccggtgtg
     2821 ctgccgtcgg tgacgtcggt gagggtgaag gcgccggtga acagccggga ccgcagtcgc
     2881 agcgtgccgt cgcggtcggc gcggacgctg atctcgtcgg cctggctgtt gctccaggtc
     2941 agcgccaccg tgtagccacc ccggccgcgc agtcccgcga cctgcccggc gggccaggcg
     3001 ctggggagcg cgggcagcag gtgcagctcc ccggtgtggc tgtgcagcag catctcggcg
     3061 atgcccgagg tggcgccgaa gttgccgtcg atctggaacg gcgggtgcag gtcgaacatg
     3121 ttcggcgcga gccggtcggt gcggaccagg tcgcgcagga gcttgtgggc gcgggcgccg
     3181 tcctccagcc gggcccagaa attgatcttc caggcgaggg accagccggt cccgtcgtcg
     3241 ccgcgcagct ccagcgtctt gcgggcggcc tcgtacagcg ccggggtgcc ccgcctggtg
     3301 atctggttgc cgggatgcag cccgtacagg tgggagacgt gccggtgggt gcgctcggtc
     3361 tcgacccagt cggcgagcca ctcctgcacg ttgccccgcg aaccgacgcg gctcggtggc
     3421 agccgatcct tggccgtacg cacctgggac cggaacgtgg tgtcgacgcc gagcacctcg
     3481 ctcgcccggg ccgcggcgtc gaacaggtcg cgcaggatct ggttgtccat cgtgggtccg
     3541 gcgcagacgc tggcgttggc gtggtgcgcc agctccggcg agttcgacgg gttcgtcacc
     3601 aggtagccga gcgtcgggtg ggcgaccagg gtgtcgagga agaactgggc ggcgcccttg
     3661 agcgccgggt agttggcctg gaggaagccg aggtcgccgg tgaacaggta gtggtcccag
     3721 atgagcgtgc tcagccaggc cccgccggtc tgccacatgc cccagaacgc gccgtccacc
     3781 accgatgcgc cccgccaggc gtcggtgttg tggtgggtga cccagccacc ggcgccgtac
     3841 tgtgcctggg cgacccgcgc gccggtgacg gtgaggtcct tgaccatgtc gaagaccggc
     3901 aggaagcact cggacaggtt cgtggtgtcg gccggccagt agttcatcgg caggttggcg
     3961 ttgaccgtgt acttcgagtc ccaggacggc gtgagcgagt cgttccagat gccctgcagg
     4021 ttcgccggct gggtgcccgg ccgcgacgag gagatcagca ggtaccgccc gaactggaac
     4081 agcagcgcgg cgaactgcgg gtcgttcgtg ctcgcgtgct gcgcgatccg cacgtcggtg
     4141 ggctggtcgg cggcggcggt gcggcccagg tcgatcgtga cccggtcgaa cagcgcctgg
     4201 tagtcggcgc ggtggcgggt gcggagctgg tcgacgtcga cgctcttggc ggcgttcagc
     4261 cggttgcggg cgatgccctg gtagtcgccg ttgacggtgc ggtagttgac gtagctggtg
     4321 ccgatcgaga tcaggaccgt cacgctggtc gcgccggaca cccgcagcgt gccgccggag
     4381 ctgctcaccg tgccgccggt gacggcggcg ttggccagcg cgaggaaccg caccgagccg
     4441 ttgaccccct ccatcgagcc ggagatgccg tcgagcgcga ctgtcgcgcc gtccgggctg
     4501 gacacggtgg tccgctgcgg gctgtcgaac gcggcggaga acgtgatcgc gttcgcccgg
     4561 tcggcggtca gccggagcac tatcacctgg tcgggcgcgc tggcgaacac ctcccgctgg
     4621 taccggacac cgttcagcac gtacgtggtg gtgacggtgg cggtggtgag gtccagcgtc
     4681 cggttgtact gcgtcgcccc gctcgccgac ccgaaggaga gccgcaggtc gccgacggtc
     4741 tggtaggcga gctgaccgcc ggggctgccc atcatggtct ggttgatcaa atcctgggcc
     4801 gaggtccact ggtcggcgaa gacgcgacgc cggatctcgg ccaggttggc cgcgccccgg
     4861 gtgttcgccg agtcgtacgg gccgccggcc cagacggtgt cctcgttgag ctggagccgt
     4921 tcggtgtcca cgttgccgaa caccatcgcg ccgagccgcc cgttgccgat cggcagggcg
     4981 cgcagccagt cggtgccggc cggttcgtcg taccagagcg ccaggtcgtt cgcggcgagc
     5041 acctgcgccg gcgccgccga gccggcgcgg gcggcggcgc tccaggcggc cggcaccagc
     5101 gcggcgccgg tgccggccgc tgcggccttg atgacgttgc gtcgtgtcac ttcagacatg
     5161 cttttctccc aaccgcgcgg atcagaggcg ggtccggatg cgcggcgctg ccctgttatc
     5221 gctaacagat tgcgcctcgc acacccggac gccgcgttcc tgccactccg cgcccagggc
     5281 tcccgaccgg gcgacacgtc ggccaacatg gactctcatg gatgaagtga catcgcgtca
     5341 aggggtgtta ccgctaacag acgcgatccg tggcgcactc gccgggccga gcggggcgcg
     5401 ggcgcggccg gccggcccac ccgggccacg tgcacgatcc gctccggcgc cacgtccagc
     5461 agcgtgccga gcgcgccacg ggtggctgcg acgtcgacga gctgactgag cgggtgcgcg
     5521 gccagcccgg ccgtgtgcag cgtcagccac atccgcatca gcacgcgtcc gaactcgacc
     5581 tgcccggccg cgtccagacc gggcggcgcg atcagcgcca gcaccccgcc gccctgcgcc
     5641 agtggatcac cgcccgcggt ggcgagcagc cggggcagcc ccagcgggcg caacgccggg
     5701 tacgccgcga gcgccgcccg cagtccggtg gccgccgccc ggcccagccc gaggcagctg
     5761 tcactgagcc cgtcgctccg gtagcgcggg cacgcccggt ccaggcgcag ccagcggcgc
     5821 agctcggcga ccaccgacgg gtcggcgtac acgtgccggt cggccgtgcg cagcagcgcg
     5881 cgcagccgcc cggccgccgg caccacgcgg gccgcgccac cggcccggcg ggcgaccgcg
     5941 tccacggccg cgaccacgtc ggcgtccggg ccgccggtga accggccccg gtgggtacgc
     6001 cggtcccaca cgtcggcggc gcgaaacggc gtccggtacg gctgccgggc cggacgcagc
     6061 cgccccaccc gccggtccga ctcgtcgtgg tcggcggccc agtccagccg cagccccgcg
     6121 tcggcggcga cgatcaggca ggtctccacg aacgcgccga gcgacagccg caggtcccgc
     6181 ccggtcgggt cgccggcggg cagcgtgtcg gccgggtccc agccgacggt gatcgcccag
     6241 cgctcgtagc gcagccgcca cggctgggtg ttgtgcgcgc tcggcgcccg ccagcacagc
     6301 ggctccagcg cgcggaacgc ggcgaggtcc atgctcaccg ctccctggcg tagaacgtgt
     6361 agccgtgcag cgggcgtccg ccgaggcgcc ggtactgggc ggccgacgcc gggttgtccc
     6421 gcccgacgta cgtgctgcgc agcgccgtgt atccgccctc gtgcaggttg cggtgcaggt
     6481 gctcggacag cagccgctgg tagccgcgcc cctggaaccg cggcaccaca cccttgacga
     6541 tcagcaccgc ctcccggcgg taccggcggc gggtggccag cagccgcagt tggttgaccg
     6601 ggttcaggtc gccgcgcaca gcgaccagga agtcgctgat gtccggtacg cagagcacga
     6661 acgccaccgg gtgcccgtcg cgggtcaggt agagcagcag cgagtcatcc agcaggtacg
     6721 ccagcccgtc ggtctgccgc cgcagctgcg ccgccgagat cggcgtgtag tagccgagct
     6781 gggcgaagga gtcgttgagc atcccgcgca gcaggcccag ctgttcgtcg agccgccggc
     6841 tgttcccccg gtgcaggtcc agccgggagc cgtcgggctg gacgcccagc gcgggcggcg
     6901 gcccggtcgg tggcggcacc gggcagatcc aggtgtcgga gacgaaccgc ccggtgaacc
     6961 cgttctcctc gtaggcgtcc gggtagtacg gcgggttcca cgcgctgtcc acgaaacccc
     7021 ggtcggcgta cccggaggtg atcacgccac cggcctggtt gggcagcagc gccaccggcc
     7081 cgaacagcag gtcccggccg ggtgtggcgt acgtggcgat cgcgtcgaac agcggccggg
     7141 cggcgtgcgg cgtgaactcg gtgagcccga acaactggca ccggcggccg agcttggcgt
     7201 cgaggtcggc gtcggtgtgc agcgtggtcc gcccgaccac cgcgccggtg gcgtcgcgca
     7261 gcacgtacat cggcacgccg tcgcgccacc agcggcggat ctgctgccgg ggcgtcggca
     7321 cgtagcggga ctcgtccgcg tacagccggt cggtgagcgc gaggaagtcg cgcaggccgc
     7381 gccggccggt cacgcgctcg aaccggtggc cggtcaccgg cgcaccgccg gtccggtggt
     7441 ctccgcgccc agcggcgtga accgctcgat gtggcccatc gcgccgtcct cggcccgcca
     7501 cgcgccgttt gagtagccgt ccggggaggc ggtgtagagg cggatgaacc cggccgtggc
     7561 gttgcggttg ccgtcggtca gccacatcat cagcttgcgg tggtgccggg tccgggcgaa
     7621 gcgcagcagc gcgtcgcggt cggtgaagaa cgcgatggtg ccgagcgtca gcgggaactg
     7681 ccagtagacg gtgtgccagc agtagccgga catccggcgc atgtcgcgca ccatccggat
     7741 ccagtcgggg gccaggcgca gcagcaccag cgggttcgcg taccgggtgc cgccgatgaa
     7801 catggcgccg gcgcgggcct gggccggggc gcgggagaag tcacgggtac gcatcgctca
     7861 cctcaccagg tagacgttct tgatcttctg catggcggcg aacgggccgc agtccggttc
     7921 gtgcagttcc acccgcaggt caccggcggt cgggtcctcc accagggact gcgcgaagtc
     7981 ccgcgacacc gaggtcaggt gcgcgcgtac cccgtcgcgg caggcgtcgg cgagcgccgc
     8041 gcgggccgcg gcgtccagcg ggcggcgcag ctccacgtgg atcaccggcc gggtctccag
     8101 cgccgcgtcc tcgtgcagcg tgagacagaa cctgttgatc tcggcggcgt acgggttgcc
     8161 ggtgtagagg ccgtactcga cgtcctgcgg gtagaggttc gcgcccaggt aggacacggt
     8221 ggagtcgctg cggccgaaca acagcagcaa cggcagcgtc atccgctcct cggccaccgc
     8281 ggtacggaac tcggcgcggc gcaccgggtc ggcgtgggcc agctcgacga tccgccggta
     8341 cggcaccagc agcgcctcgt cgccgacgtt gtagcgcagc cggggctgga gcacgtgcgg
     8401 gccggtgacg gtgcagagca gttcccgccg ctcgttggtc tccaggtagg tggcgaacgg
     8461 gttgtactgg aacaccatcg gcagccgctg ctcgccgcgg cccagcagtt ccgcgcgcag
     8521 tcccgcgtcg gtgcgcagcc gccgccgcaa ccagaccgtg aaccgggtct ccgcgccgat
     8581 gccgatggtc aggtccgacg ccccgtacgc cgaccgcacc cgcacgaacc gctgctccag
     8641 gtagtcgcgc aacgcctcgg tcatcccctc gccgccgcaa ctggcgaaga tccggtaccg
     8701 cgaccacgga aagtcctcgg cgtcgagccg gtcccgcagg tgcttgagga acggcgggta
     8761 cgcggtcacg aggtagtcgt ggccggggcc gaactcgcgc agcgtgtcga cgatcttccc
     8821 caggtcgggg ccggtgttct tcaccgtcgc gatccgggcc atcgccgcgc cggtcgtggt
     8881 gccggtcgcc caggcgccca tcgagtacgc gttgatgacg aacggtcggc gcatcgggaa
     8941 cgccagaccg gtgtacccgg cgatgtcgcg gtgcaccgcc cgcagctccc gctcgccgcg
     9001 cggccagttg aacggccgcc cggacgagcc ggccgactcg tcgaccacca cgccccgctc
     9061 cggcatccgc ccgtcccggc accgggccga ggcgtcgtac gccatgacgt acccacgttt
     9121 gtcggtctcc gggaagtccc gcagccggcg gcgcagcccg cccgggcggg cccgcaggaa
     9181 cgcctggtac gcgggcaccc gccgggcggc gcggacgcag gtggaccgcg cgttcgcggc
     9241 ggcgagccgg tcgaggaccg ggtggtggcg ccgggccagc cacctccagc cggcggggtg
     9301 gtgggcgatg agccgggcca gcgcggcgac cgcgcggccg gcgggggcca gcgcggcctc
     9361 ggcgggcagc ggcgtgtcga cggtacgcaa ggcggcgtgt cggtgcagcg tctcggccat
     9421 gacaaggatc ctgtcgacgc cgcgacgcgg acacatgagc gacgggacgg tactgcgctg
     9481 agtacccgta cccagtcgcg aaagctgccc gggctggcca cgctcagtca ccatggcgac
     9541 actcgcctgg tgcgtcgtgc ctggtccggt gacacttcgc ccatgacaga cggcaagcgt
     9601 gagcgcacga acgagcgctt cgagaaggtg gccgaggaga cctcggagag cgtgacccac
     9661 gcggccacgg tgctggagga ggaactcgcg gcggggctgg ccggcgcacg gcgactcgag
     9721 gagaagctga ccgagagccg ccgggtcgac ccggaggcgt tcgacgaact cgtcgcgcgg
     9781 gtccgcaccg acgggcacgc cctgatcgac accgtggtcg ggcagctgaa gatggccgac
     9841 gaccagcgcg gtgaggtgat ccggcggtac acgtcggacg cgcacgacgc gctggacacc
     9901 gtactcaatc tggcgcggct ggcccccgag gtcgcaaacg ggctcgcgga ccggctggcg
     9961 tcgccggccc cgaagcggcc gacggaccgg tagccgcgcg atggcgccga ccgccggggt
    10021 ggccggcggg cacgtggaac ggatgctgga gcgctatcgc gggctggccc tcggcgcgct
    10081 gctcgacgac gtgcccgacg gcggcccacg ctacctctac gacctggtcg cggagtatcc
    10141 gcgccggtgg ggcaaggggc tgcgcgccgc gctgtgcctg gccacgtgcc gggcgttcgg
    10201 cggcggcgac gcggtgggcc tcaacgccgc ggtgacagtg gagctgttcc acaacgcctt
    10261 cctcatccac gacgacatcc aggattccag cgagcagcgg cgcggcgggc ggacgctgca
    10321 cgccgagtac ggcgtgggcg tggcgctgaa cgtcggcaac atgacgaacc tgctggcgtt
    10381 gcggcggctg gccgcgaacc gggcggcgct cggctccggg atcgcctggc ggctgttcac
    10441 cgagaccgag ctgatgatgc gccactcgct ggaggggcag gcgatcgaga tcggctggat
    10501 ccgcgacaac gtgtgcgacc tggacgccga cgactactac cggatgtgcc tgaagaagac
    10561 gtcctggtac acgtgcatct acccgtgccg caccggcgtc ctcgtggcga ccggccggga
    10621 gaacgctgtc gacgtgctgg accggtacgg ctggtatctg ggcgcggcgt tccagatcca
    10681 ggacgacgcg ctcaacctga ccggcgacta cgcccggtac ggcaaggaga tcgccggtga
    10741 cctgtgggag ggcaagcgga cgctgatcct gatcgacttc atgcgacggt gcacaccgga
    10801 ggaacgcgag cggctcgtgc gattgctgag ccgtacccgc gcgcagcgca ccgacgccga
    10861 ggtgcgctgg ctgcacgggc gcctgctcgc gtacgactgt gtggagtcgg cgcggcgcag
    10921 cgcccgggat ctcgcgctcg cggcccggcg tgagggtgag cgggcgctgg gcgccgccgc
    10981 cgacaccgag gacggccgtt tcctgctgga gctgaccgac tacgtggtgg aacgggcccg
    11041 ttagccgccc aggatcccgc gcagccaggt gagctgttcg ccctggtgtg ccgcctcgcc
    11101 gccctcgtgg tcgttgaact cgtacacccg cacgtccttg tcgccgccgt agcggtggta
    11161 ggcggcgaag caggtcgacg gcgggcagac ctgatcacgc agggcgatgg agaacagcgc
    11221 cggcgcggtg gcgcgcggcg cgagcactgc ggcgtccagg taggacagcg tgcggaacac
    11281 ctggtcggcg cgatcgcggt gcagcgcgag gtactcgacg acctcggcgt acgggctgtc
    11341 cgggccggcg acgcgcacgc cccggcggat gtcgcacagg aacggcacgt ccggcatgac
    11401 ggcggcgacg tccgggcaca acgcgccgac ggccagggcg aggccgccgc cctggctgaa
    11461 gccggtcacc gccacccgcg ccgggtcgac ggccgggtgc cgccgggcgg cctcggcgaa
    11521 gcggaccgcg tcggtgatga gccgccggta gtagtgctcg gccgggtcgg cgacgccccg
    11581 ggtgaggaag ccgggcacgg tgccggccgg gtaggggtgc gggtcgggcg tgccgccggt
    11641 ggcggcgctc cacccctggc cgcggctgtc catgatcagg tgcgcgaagc cggccgccgc
    11701 ccagaacagc ttctcgtgcg gcaggccgcg gccccggccg tagccgaggt actcgaccac
    11761 gcagggcagc ggcccgtcgg caccggcggg caggtgcagc catccgcgta ccggctcacc
    11821 ggcgaaaccg gggatcgtga ccgcgtacgt ccggatctgg gtcagcccgg tgtcgaccgg
    11881 ctcgtagacc gccgccgccg ggtcgccgcc gccgtcgagc gtgcgcgccc agaatccgtc
    11941 caggtccgcc ggcacgtcca gctccggccg gtacgcgagg cagccggcca ggtcgaggtc
    12001 ggtcagcggc acgacgcggc ctcccgtacg gcggacgcga accagccggt gatggtgctc
    12061 gggtgggtga tggcggtgcc gaccaccacc gtccacgcgc ccgcccgcag cgcctgcgcg
    12121 gcctgctccg gggtgtggat gcgtccctcg gcgaccaccg ggacgtcgac cgcggcggcg
    12181 agccgggcga ccaggtccag gtccggcccg tcgcccttgg tggtgtacgc ggtgtacccg
    12241 gagagcgtgg tgccgaccag gtcggcgccg gcagcggcgg cggcgatgcc ctcgtcgaac
    12301 gtggagcagt cggccatcac cagcgcgccg gtgcgctcgt gcacggcggc gatcgtctcg
    12361 gcgagcgtac ggccgtcggg gcggggccgg gacgtgccgt cgagcgcgac gacgtgcgcc
    12421 ccggcgtcgg cgacggccag cgcgtgttcg agcgtcgggg tgatgaagac gtcgtcgtcg
    12481 ccgtccttcc agagcccgat cagcggcagg tccaccgccg cgcggatggc cgcgatgtcc
    12541 gccaggccct gggcgcggat gccggcggcg ccgccgcggg cggtggcgag cgcgacccgg
    12601 cgcatggtgt ccgggtcgcg catgggctca cccgggtacg cctggcagga gaccaccagg
    12661 cggtggcgga gctggtcgac gagggagttc atgagacctt ccaggcgagc gaggcggcgc
    12721 cgagcagcgg cgcgtcgggg ccgagggtgg aggcgaggac cggcacaccg gccagggcgg
    12781 gcagcgtctc ggcgggcacc gcgtcacgca gcgcccgcca ccacggctcg ccgaggccgg
    12841 tgacgccgcc gccgatcacc acggcggcgg ggtcgagcac gttgaccagg ccgccgacgg
    12901 cggacccgac ggccgtgccg ccgagccgga cgacgtcgcg ggccgtctcg tcgccacctg
    12961 ccgcgagcgc ggcgacggcc cgcaggtcgg ccaccggacg gccggtacgc cggacgtact
    13021 cggcggtgag cgcgggcccg gcggcgatcg cctccaggtg cccgcgcccg ccgcaggtgc
    13081 agggcagcgt tccggcgtac gccgacggct ggtgcccggc gtgcccggcc gcgctgtgcg
    13141 caccggcgag cactgtgtcg ccgaggacga acgacgcgcc gacaccggtg cccacggcga
    13201 cgtagagcac cgtgtcgtgc ccggccgcga cgccgtgacg cgcctcgccc agcgcgtggg
    13261 cgtgcacgtc gttgaccacg gtgaccggca caccgagaca ccgagccagg tcgccgcgca
    13321 ggtccgtgcc ggcccagccg gtcagcacgt cggtggcgga cagcaccagg ccggaagcgc
    13381 tgtcgatgac gccggcgctg ccgacgccga gcgcccgtac gacgtccggc gcgtccgccc
    13441 gcagcttctc gaccaggccg gcggcggtgt cgagcaccgc tgcggcgccg gagcgaccgg
    13501 gtgtcggcgc ggtgtgccgg ccgacgacct cgccggcggc ggtgaccagc gcggctgtgg
    13561 tcttggtgcc gccgatgtcg agcgcggcga ccaggccggt cgtgctcacc tcgggcatgg
    13621 tcagagcagc ccggccagtt ccagctgggt acgcacgcgg cccgtctcgg cgtcgtccag
    13681 cggccgcagc ggcagcgaca ccgcgttgcc ggcgatgacg ccgagcaggg acagcgcggt
    13741 cttgaacgcg ccgacgcccc gggtggcgcc cgccgaggtg gccgggtcgg ccgcgtcgac
    13801 gatgcggaac agccgggtca ggcggtcctg ttcccggcgg gccgcggccc agtcgccggc
    13861 caggcaggcg cggtgcagcc gcacgtatcc ggccgggtcc acgttgccca gtccgggcac
    13921 cgagccggag ccgcccgcga gcatcatcgc gtcgaccacg acctcgtggc cggtgagcag
    13981 gctgaagtcg cgctccggcg cgtgctcggc gatggcgagc gccagctggc ggaacgcgac
    14041 gtcgtcgccg ctggagtcct tgacgccggc cagcacgccc tcggcggcga ggcgggtcag
    14101 caggtcgacg gagagcttgc tgtgcacgca gaccgggatg tcgtacgcca gcagcggaag
    14161 ctcgaccgcc gcggcgacgg cgcggaagtg ccgctcgatc tcgtgcgggc cgacgatggc
    14221 gtagaacggg gcggtcacga cgaggccgtc cgcgcccagc cgggtggacg cctcggcccg
    14281 ctccacgacc cggcgggtgg tgggttcgat gcagccggcg aggaccggca cggcgccgcc
    14341 ggcggtcttg acgatggtct ccagcgcgag gtcccgctgc cggtcggtga ggaagaccgt
    14401 ctcgccggag ctgccgaggg cgaagatgcc gtcgacgccg gcgtcgagca gccattcgac
    14461 cagccgttcc agggagtgga cgtcgacctc gccctcttcg gtcagggggg tgacggccgg
    14521 cggcacgact ccggcgaacc gcggggctgg ggtggtcaca ggttctcctc gacagactca
    14581 gttgtggtgc ggccggtcgc cgaggtggcg agcgcgacca gttcggtgtt ggcggtgccg
    14641 gcgggcaccg ggtggtggca gcggaactcg tggcccgcgc cctcggcggg gcgcggcgcg
    14701 ggcatgtcca cggcgcagcc gtcggtggcg gcccagcagc gggtccggaa cgggcagccg
    14761 ctcggcggcc gggtcgccga cgggaccggg ccgaccagcg gaatgggctc gatcggtgag
    14821 agcaggcccg gcgtggccga gaacaaggcc cgggtgtacg ggtgccggcc gccctcgggc
    14881 agcaggtcgg cgggggtctg ctcgacgatg cggcccaggt acatggtgac gacccggtcg
    14941 ctgacccgct tgacggtctg gatgtcgtgc gacaccagca ccatggccag gccgagccgg
    15001 tccttgaggt ccagcagcag gttgaggatc tgcgcgcgga ccgacacgtc gagcgcgctg
    15061 gtcggctcgt cggcgatgac cagccccggt tccagggcca gcgcgcgggc gatggacacc
    15121 cgctggcgct ggccgccgga gagctggctg ggcagcacgt cggcgaccga gcggggcagg
    15181 ccgaccaggg ccatcagctc ggtcacccgc tgctcgcgct gctgccgggt gccccggcgg
    15241 tgcacgtcga gcgggtcgcg caggatgtcg cgtaccggca tccggcggtt cagtgaggtg
    15301 gccgggtcct ggaagatcat gccgacgccg gcgccgatgt gctcgcgccg ctcggtggcg
    15361 gtcatcgacc acacgtcctt gccggcgaag gacaccgtgc cggcggtcgg ccgttgcagg
    15421 ccgacgagca ccttggcgag ggtggacttg ccgcagccgg actcgccgac gatgccgacc
    15481 gtctcgccgg cccggatgac caggtcggcg ccggtgagcg cgtagacctt ctcccggctg
    15541 aacatgccgc cgccgcgcgc ggcgtgcacc acgtgcacgt cgctcagctc ggcgatcggc
    15601 cggtgctcgg cggtggcgct catcgggccg gctccttctc gctgacggtg acggcggggt
    15661 ggtggcaggc gtacccgtgg ccgtccgtgc ccgccatggt gggcgcggtg tcccggcaga
    15721 tctcggtcgc catcgggcag cggtcggaga atcggcaacc cttcgggaag tcggccggtg
    15781 agggcaccac gccgcggatc tgggtgagcc gttccgcgcc ggtctccagg gacaggacgg
    15841 aaccgaggag cccgcgggcg tagtggtggg cgggcgcctc catcacgtcg gcggtcacgc
    15901 cggtctccac gatctgcccg ccgtacatca ccacgacccg gtcgcagacg tcgctgacca
    15961 gggcgaggtc gtggctgacc aggatgaggg cgaagccgag ccgctcgcgc agctccagca
    16021 gcagcgccat cacctgggcc tgcacggtga cgtcgagcgc ggtggtcggc tcgtccgcga
    16081 tgatcagctt cgggtcgcgg gacagcgcca tggcgatcac gacgcgctgc cgctgcccgc
    16141 cggacagctc gtgcgggtac gcggcgagcg tgcgccgcgg gtccagcccg accagccgca
    16201 tcagttcctc ggccgagcgg gtgccgccgc ggcggatcat ctgggcgagc tgggcgccga
    16261 cgcgcagcgc cgggttcagc gccgacagcg cgtcctggta gaccatggcg atctcgcggc
    16321 ccatcagggc gcggcggccc ttggcgttga gtttcagcag gtccgtgtcc tggaagcgga
    16381 tctcgccgcg tacccgggcg ccctgcggca gcaggcccat gacggcgagg acgctcagcg
    16441 acttgccgga gccggactcc cccaccaggc cgacgacctc gccggggcgt acgtcgaagg
    16501 tgagcccgtc gacgatgtcg acgccgcggt ggcggccctc gaagccgatg gacaggtcgc
    16561 tgacctgaag gaccggcttg ccctgcggca gcgggcgggc gcgctcacgc agccgctgcg
    16621 ccgcctcggc caggccgggc agctcgacca cctcgccggt gccgggctgc gcctgctcca
    16681 gcgcgtcacc gctggtggtg gacgtggcgc ggcgcgcggc cggggcggcc caggcgtcgg
    16741 acatgccctc ggagagcacg ttgagcgcca gcacggtgag caggatcagc aggccgggga
    16801 agaacgtggc ccaccagccg ccgatctgca ccatctcctt gccgaaggcg atgaccgagc
    16861 cccacgagga ggccgcctcc tgcggggcga ggccgccgcc gatgaaggac agggacgcct
    16921 cgaagacgat cgcgtcggcc accatgacgg tgacgaagac gaggatcggg gcggcgcagt
    16981 tgcgcaggac gtgccgccag aggatgtgcg ggcggcgggc gccgatgatg cgctcggcgg
    17041 ccacgtagtc ctcgccgtac tgggacagca cgttggcgcg gacgatgcgc gcgaccgacg
    17101 gggtgaacac gaacccgatc gcgatgacga ggaccagcag gctgttcttg ccgaacgaga
    17161 tgatcagcag cgcggagagc acgatcgtgg ggaaggccat gaccacgtcg aggcagcgca
    17221 tgacgacctc gtcgacgacg gtgcggctgc tgccggcgag cgcgccgagg atcgcgccga
    17281 gcaccagcgc gatgccggcc gcgccgaaac cgacgatcag ggagcgccgg gtgccggcga
    17341 ccagccggga gaagacgtcg cggccgagtt tgtccaggcc gaaccagaag tcgccgttcg
    17401 ggccggtcag cgccggtccg agaccggtct gggtggggtc gtggcgcagc agcagcgggg
    17461 cgagcacgcc gaccacgacg atgagcgcga cgaagccgag cgcgaaccgg gccgcgagac
    17521 cgagccgggc gaaggccatg ccggggcggg acagccgcgt ggtgagggac cggcgcatca
    17581 gtggcctccg cgcagtcggg ggttggcgaa gaggtagagg atgtcgacga ccaggttcac
    17641 caggacgaag cacagcgcga tggtgagcac ggtgccctgg gcgagcgcgg tgtcgttctg
    17701 ctggacggcg ctcatgatct gggtgcccat gccgggcagc gagaagatgg cctcgatgac
    17761 gacggtgccg ccgatgaggt agccgatccg caggccgagc gcggtgagcg ggttgaccag
    17821 cgcgttgcgc agcacgttgc ggccgatcac cacgcgcggt ggcagtccgg cgccgacggc
    17881 ggtgcggacg tagtccttgt cgagttcctc gaccatcgac gtgcggacga tgcgggccag
    17941 cgagcagccg accggtacgg ccagcgccag cgcgggcagc gcgagggact gcagccagag
    18001 gccgaccgag tcggcggggt tgacgtatcc accggtcggg aagatcgggc ggcggaccga
    18061 gaactcctgg atgaacagca gggccagcca gaacgaaggc gtggcgatgc cggccatgga
    18121 gacgatccgg atgacctggt cgggccagcg gtcccggtac agggcggccg ggatgccgag
    18181 ggccagcgcg atgaccagcg cgccgacgac gccgagcgcg gtgagctgga tggtcagcgg
    18241 caacgccatg gcgatcttct cggcgaccgg gaccgacggc gggaacgtca tgccgaggtc
    18301 gccgcggacg aggtcgccga ggaagtgcag gtagcgcagc ggcagcgggt cgttcagccc
    18361 gttcgcggcg cggaacgcct cgacctgcgc cggcgtggcc tggtcgccga ggacggacag
    18421 cgccgggtcg atcggggaga actgcatgat cacgaagacg aagagcgtga tgcccagcac
    18481 cagggggatc agcgtcagga atcgtcgtgc gaccaggttc aggacggtca gcatggattc
    18541 tctttctcgt ggcggggcgc cggggcgtcc cgtccggccg cacgggtcac gtgcggccgg
    18601 acgggacgga ggcgggggcg gagccccgag tgggctcagc cggtccggcc ggtgcccagg
    18661 aagtacaggc cggtggtcga ggcgcccgag aagccgtcga gcttggccgg gtcgtacgcg
    18721 gtgacgacct tggtgtgcag gatcgggtag agcggggcgt cgtccgccac catgtccagg
    18781 gcctgcttcc acagcgcctt gcgggccgcc tcgtcggagg tctgcgcggc cttgtccagc
    18841 aggtcgccca tggccttgcg gttggcgtcg ctccagcggt aacgctggcc cggccaggtc
    18901 tcgccgaagt agtaccagcg catcagcagg tcggtgtcga cgccgaagac gctcgggtca
    18961 ccggtggcca tgagcacccg gaacgtgtcc ttggggacga tgtcgccgta gatggccgag
    19021 gacggcacgg tgttgagcgt ggcgttgacg ccgatcttct tccactgctc gatgaccagg
    19081 ggggcgacgt ccttgaccac cgagttgtcg gtggtgtcga gccggaacga caggttggtg
    19141 acgccggcct cctggagcag ggccttggcc ttgtccgggt tgtagtcgta gacggtggcg
    19201 gccttctggt acgccttgtt gccctcgtcg aggtagctgg tcgccgggct gccgtagccg
    19261 ttgagcgcgg tcttgatgac cgcgtccttg tcgatggcgt agtgcagggc ctggcggacg
    19321 cgcttgtcgc tgaacggcgc ggcggcgttg ttgaacatga ggaagacctg gttgaaggcc
    19381 tgcttcacgt cgatcgtgta cttgtccttg agcgagtcga cgttcaggta cggcacggcc
    19441 tcgatggcct gcacgcggcc gccctgcagg tccgacaccc gggccgacgc ctcggtggtg
    19501 gtgttccacg tcatcgtctc gaccttggcc gggcgcgggc cgttgtaggt ctcgttcttg
    19561 ctcagcttga tgccggattc cttggacgcg ctgtccacct tgaacgggcc ggacccgatc
    19621 ggcgcggtgt cgaacgcctt ggccgctgcc gcgtcaccgg tcttggcctt gggcacgacc
    19681 ttgatgaccg agatccgctc gctgaacagg gcgaacgggt acttcagctt gaactcgacg
    19741 gtggccgcgt ccttggcggt gacgctgtcg aggaacgaga cgaagccctg catcagcggc
    19801 ggcgccttcg ggtccgccgg cttcagcacg cgggtgaacg accaggcgac gtcctcggcg
    19861 gtgacggggg tgccgtcgga gaacttcgcg ccgtcgcgca gcgtcacggt gtacgtgagg
    19921 ccgtcggcgc cgggcgtcgg gtcgctcttg gccagcgcgt tgtagggttc ccgcgtgatc
    19981 gggtcgaggt ccacgagacc ctcgaagacg tgctggttga cggcggtcgc cacggcggag
    20041 gaggcgttgc ccgggtcgaa accgctggag agcgtgaacg ccagggtggc ctcgatcgac
    20101 gtgcccgcct tcccgccgct gaccgcgttg gtcgaggcgg gaccgccgct gcaggccacc
    20161 agcccgaggg cgagggtcgc tccgagggag gcgacggcca gggggcggac gcggcggcgc
    20221 ggcacgcgcc agctccgcga cttaccggtg gtgctcacgt agatgcctcc ataggctctt
    20281 catgcgctcg cgtcgccgct cgcgccgggg atgtgaagtg taaggtgtat gacgtctgac
    20341 gtctgatgcc ggtagggtga gggtgtcaga ttcgggaacg aagggcaagg ggcagatgac
    20401 gaccattgac gccagtccgc tacgcggcgc cgagcggccg agccctcgcc ggcaggaggt
    20461 cgccaccagg atcaaggagt acatcctgca caaccgcctc aagccgggca atctcctgcc
    20521 caccgagacg gagctgtgcg aggcggtcgg cgccagccgc tccagcgtcc gcgaggccgt
    20581 caagatcctc tccgcgctcg acatcgtcga ggtgcgccac ggccacggca cgttcgtcgg
    20641 ccggatgtcc ctcaacgccc tggtggagag cctgacgttc cggggcctgc tcagcggcga
    20701 ggacgaccac cacgtactgg cccaggtcgt cgacatccgg cagacgctgg agcaggggct
    20761 ggcggccacc gtcatcgacg ccctggacga ggagcaccgg tcggagctgt ccgcgctcgc
    20821 cgacgagatg cgcagccggg cggcacaggg cgaggacttc ctcgacgtcg accgggcctt
    20881 ccacctgaag ctgatggagc cgctcggcaa cgacctgctg gtccagctga ccgaggcgtt
    20941 ctggcaggtg caggccatcg tcgcgccgac cctgcgcacc gagccggagg accgggtcat
    21001 caccgcccag cggcaccagg ccatcgtggc cgccctcacc gccg
//
