LOCUS       NZ_BBVA01000002        21905 bp    DNA     linear   CON 10-SEP-2024
DEFINITION  Micromonospora sp. NBRC 110037, whole genome shotgun sequence.
ACCESSION   NZ_BBVA01000002
VERSION     NZ_BBVA01000002.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Micromonospora sp. NBRC 110037
  ORGANISM  Micromonospora sp. NBRC 110037
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Igarashi,Y., Komaki,H., Ichikawa,N., Hosoyama,A. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Micromonospora sp. NBRC 110037
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2438518)
  AUTHORS   Hosoyama,A., Ichikawa,N., Kimura,A., Ohshita,R. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 106x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001652995.1-RS_2024_09_10
            Annotation Date                   :: 09/10/2024 02:06:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,195
            CDSs (total)                      :: 6,136
            Genes (coding)                    :: 6,073
            CDSs (with protein)               :: 6,073
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 15 of 63
            Pseudo Genes (incomplete)         :: 53 of 63
            Pseudo Genes (internal stop)      :: 4 of 63
            Pseudo Genes (multiple problems)  :: 9 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1943984
            Orig. end                         :: 1965889
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBVA01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21905
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /region_number="11"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..21905
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="interleaved"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..21905
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11905](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11905
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(327..341)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            complement(604..2724)
                     /gene="glgX"
                     /locus_tag="A4R25_RS07945"
     CDS             complement(604..2724)
                     /EC_number="3.2.1.196"
                     /GO_function="GO:0004133 - glycogen debranching enzyme
                     activity [Evidence IEA]"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005980 - glycogen catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glgX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788443.1"
                     /locus_tag="A4R25_RS07945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycogen debranching protein GlgX"
                     /protein_id="WP_064446146.1"
                     /sec_met_domain="CBM_48 (E-value: 1.6e-20, bitscore: 70.1,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 1.7e-16, bitscore:
                     57.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVWPGESYPLGATYDGMGTNFAIFSEVAEKIELCLFDEWDIGTE
                     RRVELREVDAYVWHAYIPGVEPGQRYGYRVHGPWNPAEGLRCNPHKLLLDPYAKAVDGE
                     IMWHPSVYDYEVGGDPDRMNTEDSAPYMPKSVVVNPYFDWGNDRPPRTPYHHSVIYEAH
                     VRGLTMRHPGIPEELRGTYAAIASPVMIEHFKRLGVTAVELMPVHEFVHDHRLADLGLR
                     NYWGYNTIGFFAPHHGYSALGRLGQQVQEFRGMVKALHAAGIEVILDVVYNHTAEGNHL
                     GPSLSFKGIDTPSYYRLSEDDRRYFVDYTGTGNSLNVRSPHSLQLIMDSLRYWVTEMHV
                     DGFRFDLAATLAREFYEVDRLSTFFEVVQQDPVVGRVKLIAEPWDVGPGGYQVGNFPPQ
                     WTEWNGKYRDTVRDFWRGEPATLAEFASRISGSADLYQDDGRRPFHSINFVTCHDGFTL
                     ADLVSYNDKHNEANGEDNRDGESHNRSWNCGVEGETDDPGVRALRARQRRNFLATLMLS
                     QGVPMLGHGDELGRTQRGNNNAYCQDSEIAWVDWDRADDELLDFVRRLTDFRNRHQVFR
                     RRRFFTGLPVGGRAAGSGLPDLAWYTPDGREMTGEDWGNDFGRSVALFVNGDGIGERGQ
                     YGQRHRDDSFLLLFNAHDAPLDFTLPGEEFGSRWELVISTAEPDPEKTTLVEAGGTVCV
                     PDRSLLVLERTA"
     misc_feature    complement(2947..2965)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            3268..3486
                     /locus_tag="A4R25_RS07950"
     CDS             3268..3486
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS07950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_113973761.1"
                     /transl_table=11
                     /translation="MGESRNLSIDLSDLDTTAVSWSGAGDEASAGLYAMPTGGGITLTD
                     PSAMGKGSCGGAACQGRPIQWCCVNCH"
     gene            3581..4933
                     /locus_tag="A4R25_RS07955"
     CDS             3581..4933
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012745.5"
                     /locus_tag="A4R25_RS07955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_082930928.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2e-23, bitscore:
                     80.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVEPGRAVELSVVIPTHADAPCLELTLRSLRRQTLDPDRFEVIV
                     VRDGGDGSQYSGIADAGKGLRLHFVERPERGGRAAARNEAARRATAPLLLFLDADSYAT
                     PDLLRRHLDHHRDPSAPAVLMGRRDETGIEHVHAALADQPTMPVPRLRGRGGGDMRFGT
                     EEGPSGDDWLLAGWLFCFTHNASVRRDVFEAVGGFDEGFGLRWGLEDMELFYRVHAHLG
                     VLNRNFAYDDLAAVYHLPHHRNVIQNWNDFMDNLDRVALKYPVVEWEFAGPVDVARAAE
                     RVVHYRRAMDDCVRRSWCRIGPAVQRLAGRLPGDRVLWVGTGSAEAGLPDGALTYDYGA
                     PAGPANFHLVGIRPPVAADSLDAVVSVDFWRYLYWEDLCQFVNVAGALADEVHLVSTGA
                     ELSARFDPDPASLGYLGRVMGAAFETTLTEVDGLGTVLRLRPHHRAAVAAG"
     misc_feature    complement(3588..3601)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            4951..5958
                     /locus_tag="A4R25_RS07960"
     CDS             4951..5958
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072249.1"
                     /locus_tag="A4R25_RS07960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_043324526.1"
                     /transl_table=11
                     /translation="MPVIEASGLTKRFRIADKQPGLRGSLRHLVRPRHVEHVAVDGVDL
                     SISSGEAVAYVGPNGAGKSTTVKLLTGILHPTAGRVRVCGLDPHRDRHANARNIGVLFG
                     QRSQLWWDLQVRDSLALLRDIHRIPRARYAARLEEFDALLGLGRLLPVVARQLSLGQRM
                     RADLAAALLHAPPVVFLDEPTIGLDIVARQAVRDFLRAQRASGTTVLMTTHDIGDIEQV
                     CRRLVIIDGGRIIFDGSIDAVRRLVADQRTVHLTLGADWHGDLDADLPGVRLVHDGSAR
                     QIAVTFDHGAYGAGEIVSVVARRAPVVDIRIDEPSIEDVVRRAYAGELSPSVPA"
     gene            5955..6749
                     /locus_tag="A4R25_RS07965"
     CDS             5955..6749
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017946.5"
                     /locus_tag="A4R25_RS07965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_043324528.1"
                     /transl_table=11
                     /translation="MRAYLTLARMSWSTLLIYRGEFLLQLTGVVVQTVALFAVWQAVFA
                     GAAGGEVGGLSWEQMKGYLVVAFLTGGLLSSFTDAQIAGPVLHGTVALDLVRPIDYQLS
                     RFALSLGYVVGEVLTVAVMAATLVSAFGGAALPAAGQAGLFLLSLLAVVPLKFGLVYLV
                     GLLCFWTGNFHGLSLSRVAVTNILSGALVPIALFPGWLQVVCQLSPFPGIVSTPALIYL
                     GQARGAEAVTLIGVQLLWVLVLWGAARLLWSAGVRRLTAHGG"
     gene            6757..7545
                     /locus_tag="A4R25_RS07970"
     CDS             6757..7545
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014690183.1"
                     /locus_tag="A4R25_RS07970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_223201086.1"
                     /transl_table=11
                     /translation="MMHEARIYRRLLGAHLRAVLEYRADALLTIGATVLGQLAGLVFVV
                     MVFRQVTALGGWTRWEVLYVCAMVMLAEGVGSLLFEGTWHLGGLVNLGLLDYLLVRPYP
                     VVLQVTGNAVGFNGLGNVGFGAALLGAAAVHLDLAWTPLTVLWAVVLLASGVLVKLAVN
                     LATNAVVFWLLSPSSSLAASVHTLGDLARYPLTLYGTGLRSLLTLVPVAFVGYFPTAAL
                     LDKGASTTAGALTPVVAAACAAGAWAVFRAGLRRYESAGS"
     protocluster    6902..18851
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11901:13851](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      11902..13851
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            7547..9130
                     /locus_tag="A4R25_RS07975"
     CDS             7547..9130
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS07975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_064446148.1"
                     /transl_table=11
                     /translation="MAATRAGVAGRYLAAVRDDTGQPTAYLPPCGKRYPGATRRPLRWP
                     GPGSVPLGDGCLDRLSAMLLGYAPRRAETITLAGLSALTGAPSDTPTPSRLLPGWHTLR
                     RSVPSGGAFHPNEIYLAWAGSPDLAAGVYHYDPPHHCLELLRPGSPAARLDRLLGVAAA
                     PRHALLLTHRPWKNTSKYGAFGYRLGIVDSGVLLAQLLTSPVDATPRLDLDPALAGELL
                     GLDAELEALYAAIEFPAHADVPGTPLASGGPPPATGLDHDRLGHEAAHPSAVALHRARY
                     DRHADAEPPSAGRLPADGVPAQRLPADRLPVGPAAGRALDLPPARPLDLVAAAARRASA
                     ANLGPGLTAGQVADILACAAGRAGSPALAALARQPLYPELWCLARTVDGIPADAYRYQP
                     HHHRLVPTGPPGAADDAAAYPHRVDRRMVTRGATLYLVHAGSRPVDQLSPASFHRLHLL
                     AGVALHLAGLAATATGAASRALGGLTADAVAARLGLPDGASPLTQLLVGTPAPRPGALA
                     AHLTEGNPHG"
     gene            9123..10004
                     /locus_tag="A4R25_RS07980"
     CDS             9123..10004
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (13-278). E-value: 3.4e-28. Score:
                     91.1. Matches aSDomain:
                     nrpspksdomains_A4R25_RS07980_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1046: Dioxygenase TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014698.5"
                     /locus_tag="A4R25_RS07980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_064446149.1"
                     /sec_met_domain="TauD (E-value: 1.1e-26, bitscore: 91.1,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEQDVPALVGTPTPDAVLAAVAEHGAVLLRGGWRHEDYVALGDA
                     LMTASPYQGGFHDERDVIGGDPTTTTVTRGTQGMPLHREASYAPGAPDLLMFRCERPAA
                     DGGATTLCDGLALLAALPATVRAACEELTLRWESELPTPVWQRMCGTTDPEAAERMLRQ
                     WEPYLRPWESIHIDVDEDAMTVGFGTRCTPPTLFEGVPAFCNSLFISRPQPGEYHDRRL
                     RVRSGTGAPVPEDLVATAADVAARLTVAVPWRSGDVLVVDNSRYLHGRQAFTDAGRAVA
                     VRMGHLRKETAA"
     aSDomain        9162..9956
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS07980_TauD.1"
                     /evalue="3.40E-28"
                     /label="A4R25_RS07980_TauD.1"
                     /locus_tag="A4R25_RS07980"
                     /protein_end="278"
                     /protein_start="13"
                     /score="91.1"
                     /tool="antismash"
                     /translation="TPDAVLAAVAEHGAVLLRGGWRHEDYVALGDALMTASPYQGGFHD
                     ERDVIGGDPTTTTVTRGTQGMPLHREASYAPGAPDLLMFRCERPAADGGATTLCDGLAL
                     LAALPATVRAACEELTLRWESELPTPVWQRMCGTTDPEAAERMLRQWEPYLRPWESIHI
                     DVDEDAMTVGFGTRCTPPTLFEGVPAFCNSLFISRPQPGEYHDRRLRVRSGTGAPVPED
                     LVATAADVAARLTVAVPWRSGDVLVVDNSRYLHGRQAFTDAGR"
     aSDomain        10001..10234
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R25_RS31410_Thiopeptide_F_RRE.1"
                     /evalue="1.20E-21"
                     /identifier="RREFam004.1"
                     /label="A4R25_RS31410"
                     /locus_tag="A4R25_RS31410"
                     /protein_end="78"
                     /protein_start="0"
                     /score="67.5"
                     /tool="antismash"
                     /translation="MRVKLRDDLMYVPVDDGVYLETGLAGTHLAGASAYGLVQRLAPHL
                     DGTRTVEALTAGLPPAQRQLVTDLVRMLVRRGI"
     gene            10001..11905
                     /locus_tag="A4R25_RS31410"
     CDS             10001..11905
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS31410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_064446150.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 8.7e-20,
                     bitscore: 67.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     2.4e-13, bitscore: 46.7, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVKLRDDLMYVPVDDGVYLETGLAGTHLAGASAYGLVQRLAPHL
                     DGTRTVEALTAGLPPAQRQLVTDLVRMLVRRGIARDLDSEPPHTLRDWELDTYRDSIAF
                     AEHVTDAPLSRFEAFRDGRVLLVGAGAGMLALVQTLFELGLRTASLVETTETGTERDGF
                     RRIVQRRRAEDPTTGLTLLDAAAALDTDEGLAGLLTGYDAVLHCAARPMAGRATRLNRA
                     ARAIGVPVLHAVPGGAEAWIGPTGGGVTGGCWECGLLSRQGAGLPPGDADEPDTTSEWL
                     SAPVCGLIGAALGFAYLRHRVGAETTATNRMTRVDLETAVTSEHLLDVHPRCRSCRPPA
                     PYADLAAHVDAMAARTPVGVEEFVARMPFLVDARLGPLLAIDTGAHSQISVSCVEATVV
                     DLAGGAPRLLTAVGASREQALLRAATAALETLAARACAGDTATVWWDTARGAVVDAQPD
                     GVVIAGGHTWAEARGRAILKLRRAAATPPEVADGGPPGGWLDRARWPEPTRVMAHELAL
                     LGHEPRAWHDGSSTPTVFVAVGGGWVARSCATDTDTALANAMQAAVAVLTGRRPDGAEI
                     GPDVGGHDWDTALPPLLRELARDGRSLLVRPADSLPGAQRVMPFMIRAAWSPRAGSSA"
     aSDomain        10004..10273
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R25_RS31410_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.40E-15"
                     /identifier="RREFam011.1"
                     /label="A4R25_RS31410"
                     /locus_tag="A4R25_RS31410"
                     /protein_end="91"
                     /protein_start="1"
                     /score="46.7"
                     /tool="antismash"
                     /translation="RVKLRDDLMYVPVDDGVYLETGLAGTHLAGASAYGLVQRLAPHLD
                     GTRTVEALTAGLPPAQRQLVTDLVRMLVRRGIARDLDSEPPHTLR"
     gene            11902..13851
                     /locus_tag="A4R25_RS07990"
     CDS             11902..13851
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="A4R25_RS07990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_197494856.1"
                     /sec_met_domain="YcaO (E-value: 4.3e-71, bitscore: 237.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.7e-88, bitscore:
                     292.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVTTTPAVPAPSDVAPRPGLRILGVGALRRAVEQALGAAPVTD
                     VDVFVVDGPPEDVDVAARAAADAGRSFLPVYTTPRGVRIGPFVTPGRPGCHHCLQVRQR
                     RARTTGTPHRSALWQGLYDGTVQPARPVLGPPVRAAVAALVADELSRVAQGGDGRCAEA
                     VLEVATASMAVKRHRFVPEPGCPVCGPLPDDGPGAGTFTLTSRPKRAPDDYRARSLPDE
                     HLALLAALHDEETGLLSSITVHHNHPMVLAGAIGGPLCCGELAGYGRTFTYPASVAVAV
                     AEALERLGGNVPRARRTVTRASFRELGPRRAVEPTEFGLPPAPPDDHAVAYDPDRPVEW
                     VYAYSFRRGGPVLVPETFAYYGSHGTGFGPECSNGCALGANLEEAILHGIFEVAERDAF
                     LSTWYARLPVPRVDPMTSADPMTRVLVDWIQRTTGSRLDVFDITMPEGVPAVWLMLVDE
                     EVRPGRPRAFCGAGAHLDPERALWSALVELASVAEATREMVAEDTTAPGLVADSDLVRT
                     MEDHLLAAADPDAWPRFAFLYERDEIRSMAEAFPPAARYRPAADLLDDLRHVTGRYLDE
                     GLDVVVVDQTAREQEAVGLTSVKVLIPGLLPMTFGHRNRRVDLPRLRELPVRLGHRAEP
                     LAPEEINPYPHPFP"
     gene            14120..15517
                     /locus_tag="A4R25_RS07995"
     CDS             14120..15517
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477022.1"
                     /locus_tag="A4R25_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_064446151.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 4.2e-38,
                     bitscore: 127.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLRVGAQPATATDRLHRPTLTSRPAPPSPAGAGPRTRRILMLS
                     WEYPPVLVGGLGRHVHALSVALAAAGHEVTVVTRHAEGAPLEEYADGVRIVRAAEDPVT
                     FPLATGSLLAWTMAFNHTLTRAALRAASSGAYDVIHAHDWLVAHTAMTLREHLDVPLVT
                     TIHATEAGRHQGWLPEEMNRTIHGVEHWLAGESGRVIVCSGYMRDEVGALFGVDAARVD
                     VVPNGVEPHRWRVPASAVAAARARFAADGPLVTFAGRLVYEKGVQHLLAGLPRLRDRHP
                     GLRAVIVGDGPYRADLEAEVHRLGLGGTVSMPGFLGGADLPAVMAASDCFAVPSIYEPF
                     GMVALEGAAAGAPLAVARTGGLAEIVEPGVTGMTFAPHDPDGLVEAVHALLSDRDRARV
                     LARRARAMVHERYGWAAIASRTAAAYAAAIAGDPSFTAARAQHRMTHGRPTPRVPEGNL
                     LTAAGLR"
     gene            complement(15697..16980)
                     /locus_tag="A4R25_RS08000"
     CDS             complement(15697..16980)
                     /EC_number="2.3.3.16"
                     /GO_function="GO:0046912 - acyltransferase activity, acyl
                     groups converted into alkyl on transfer [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018252835.1"
                     /locus_tag="A4R25_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="citrate synthase"
                     /protein_id="WP_064446152.1"
                     /transl_table=11
                     /translation="MTEVKLDHPGGQLSMPVQSAVEGPAGIGVSKLLKETGMTTYDPGF
                     VNTASCSSAITYIDGDAGILRYRGYPIDQLAEKSSFLEVSYLLIYGELPTQAQLSEFSE
                     RIRRHSLLHEEMRRFFDGFPRDAHPMAVLSSAVSAISTFYQDSLDPFDSEHVEMSTVRL
                     MAKVPTIASYAYKKSIGQPLLYPDNSLGYVENFLRMTFGVPAEPYEVDPVVARVLDMLF
                     ILHADHEQNCSTSTVRLVGSSNANLFASVSAGVNALFGPLHGGANQAVLEMLQKIQADG
                     GDVRSFVQKVKDKQDGVKLMGFGHRVYKNYDPRAAIVKKAAQDVLGRMSKPDPLLDLAV
                     QLEEIALADDFFVSRRLYPNVDFYTGLIYKAMGFPTKMFTVLFALGRLPGWIAQWREMI
                     NDPETKIGRPRQIYTGATERAYVPADQR"
     misc_feature    complement(17075..17093)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.96"
                     /tool="antismash"
     misc_feature    17122..17136
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.51"
                     /tool="antismash"
     gene            complement(17157..19202)
                     /locus_tag="A4R25_RS08005"
     CDS             complement(17157..19202)
                     /GO_function="GO:0008484 - sulfuric ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477023.1"
                     /locus_tag="A4R25_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfatase-like hydrolase/transferase"
                     /protein_id="WP_064446153.1"
                     /transl_table=11
                     /translation="MAERTLAPPRDHTAGPDRRERPPWWRSELARLAEVTALVGLVVTQ
                     PLLDVLGRSPDFFLFHRASRGDVLLLVALIALAPTVPFALLGALAVPAGRLIRAAVHTT
                     FVGLLLAALAVQAGRHVTPLRGVPLLVAAGVAGAAGAAAHRRWRAPRRVLRVAAAGPLV
                     FVGLFLFASPASAVVLPRGEGGAAGIAGAGAHPPVVMIVLDELPLVSLLGPDGRIDAER
                     YPNFAALAAGSTWYPNATGVSGWTPYALPAMLTGRYPEQGAAPHYSQYPDNLFTALGGL
                     YRIKAEESITRLCPPSRCEQATTPEQGLGVLVRESGKLMGRIAAPVDSRVDPEDSYRER
                     TAAEAGLDAAEPVPDDPKFRWDTLDDNQPARFTSFLAGLRPDPRPTLHFLHLLMPHSPW
                     AYLPSGAHYFAPEDLPNDGTGWVDLARARHLAQLGYTDRLIGETLRTLRATGLYDKALV
                     VVTADHGVSFRRDWQGRGMDAIEHAANEVAWVPMFVKEPGQRAGRVDDRNWEHVDLLPT
                     IADETHMRVPWQMDGRSAKAAPRERADKRFYDRPGQPVTITGGVPAPLPPPAADPLVGT
                     RVGNVPMGGSATVANRDAFDAVDPARGGLPALVWGTVPDDVPDGTRLAVAVNGTVGAVA
                     PVVPPDAGGRRFAAFLPDDRLFAAGANRLDLYRVGDDGALRRLTLS"
     gene            complement(19195..20610)
                     /locus_tag="A4R25_RS08010"
     CDS             complement(19195..20610)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286006.1"
                     /locus_tag="A4R25_RS08010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_064446154.1"
                     /transl_table=11
                     /translation="MTVPDTGVRVEPGSFRDPGNRVFHRGEEVLRGLDERSARDWRALS
                     VTDFFRRAAERGQIVATEELTPTPVDTQWAAVLRHERIPFVSHPYEWSYAMLRDAALLH
                     LDVLRAALEAGFTTKDGSAYNVQWRGARPVFIDVGSFEALRDGEPWAGYRQFCQTLLYP
                     LLIQAHLGLDFQPFLRARVDGVEPDQMRRLFGGARRWRAGVPTHVHLHGAMQARNSAAS
                     TTDVRAQLRAAGFSRELALATVRGLTKLVRRLDHRPGDSHWADYQRTCAYSVPDRQAKE
                     EFVDRAVAATGGGSALDLGANDGRYARIAARHAAHVVAVEQDPAVVDTLYRALRDEGET
                     RILPLVMDLADPSPGGGWRGVERAAFADRARADVVLALAVVHHLAIGRNVPLPEVLDQL
                     TALTATGGSLVVEFVHPDDPMARRLLANKPDGLFPDYRRDAFEALLARRGRVVARTELP
                     SGTRTLYQVVVGG"
     gene            complement(20607..20765)
                     /locus_tag="A4R25_RS31415"
     CDS             complement(20607..20765)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787270.1"
                     /locus_tag="A4R25_RS31415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_166456093.1"
                     /transl_table=11
                     /translation="MTHLAYLDAGSGSLIVQAVVGGVAGVAVAAKLYWRRLVSRFRRQP
                     SDQGPTA"
     gene            20945..21346
                     /locus_tag="A4R25_RS08015"
     CDS             20945..21346
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286004.1"
                     /locus_tag="A4R25_RS08015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_043324537.1"
                     /transl_table=11
                     /translation="MTPQFDLVGAVVTDMARTLDFYRRLGLPIPAGAETEGHVEVTLPN
                     GVRLAWDTVEVIRSFHPDFDPSGGNNRMSLAFRCADPAEVDRWYAELTAAGHHGELPPW
                     DAFWGQRYAVLHDPDGNGVDLFAPLPAGD"
ORIGIN
        1 ggacacggcg aagaaccggc ggtacgtcag ctcggcgtcg ccgcgccgcc agttcaccag
       61 ctcgtagtgc tgccggtcgt gcacctgccg gggcgtcccg tcaccggtgc cgtcggcgac
      121 cgggaagcgg tgctcgtggt agcgcagctc cccgtcgacg agcttcaggt cgtcgagcgc
      181 gtcggcgctg tcggcgagca ccggcagcag cagccgcccc cggtcccagt cgatgtcgaa
      241 ccagcgcgcg tacggcgatt cgcgtccccg ccgcagcacg tcccaccagg ccgggttggc
      301 ctcgggccgg gcgacgccgg cgtggttggg cacgatgtcc acgaccaggc ccagccgggc
      361 cgcgcgcagc gcccggacca gccgggcccg ggcgggctcg cccccgagct gcgggttgac
      421 cgcgcggtgg tcgaccacgt cgtagccgtg cgtggagccg ggcgtggcgg tgagcagggg
      481 cgcggtgtag aggtgggtga cgccgagcgc ggcgaggtag cccgccagct cggccgtggc
      541 gtccaggtcg aagccgggac gcacctggac ccggtaggtc gagcgggggg tgtcgggcat
      601 gggtcaggcc gtcctctcca ggaccagcag cgagcggtcc ggtacgcaga ccgtgccgcc
      661 cgcctcgacc agtgtcgtct tctccgggtc gggttccgcg gtgctgatca ccaactccca
      721 ccggctgccg aactcctcgc cgggcagcgt gaagtccagc ggcgcgtcgt gcgcgttgaa
      781 cagcagcagg aacgagtcgt cccggtggcg ctggccgtac tggccgcgtt ccccgatgcc
      841 gtcgccgttg acgaacaggg ccaccgagcg gccgaagtcg ttgccccagt cctcgccggt
      901 catctcccgg ccgtccgggg tgtaccaggc caggtccggc agtccggagc cggcggcccg
      961 gccgcccacc ggcaggccgg tgaagaaccg gcggcggcgg aacacctggt gccggttgcg
     1021 gaagtcggtg agccggcgga cgaagtccag cagctcgtcg tcggcccggt cccagtccac
     1081 ccaggcgatc tcactgtcct ggcagtaggc gttgttgttg ccgcgctggg tgcggcccag
     1141 ctcgtcgccg tggccgagca tcggcacgcc ctgggacagc atcagcgtgg ccaggaagtt
     1201 gcgccgctgc cgggcccgca gcgcgcgtac gcccgggtcg tcggtctcgc cctcgacgcc
     1261 gcagttccag gaccggttgt ggctctcccc gtcccggttg tcctcgccgt tcgcctcgtt
     1321 gtgcttgtcg ttgtaggaga ccaggtcggc cagcgtgaac ccgtcgtggc aggtgacgaa
     1381 gttgatgctg tggaacgggc ggcggccgtc gtcctggtag aggtcggcgg agccggagat
     1441 gcgggaggcg aactcggcga gcgtggccgg ctcgccgcgc cagaagtcgc gtacggtgtc
     1501 gcggtacttg ccgttccact cggtccactg cggcgggaag ttgccgacct ggtagccgcc
     1561 ggggccgacg tcccacggct cggcgatgag tttcacccgg ccgaccaccg ggtcctgctg
     1621 caccacctcg aagaacgtgg acaggcggtc cacctcgtag aactcgcggg ccagcgtggc
     1681 cgccaggtcg aaccggaagc cgtcgacgtg catctcggtg acccagtagc gcagcgaatc
     1741 catgatcagc tgaagtgagt gcgggctgcg gacgttgagg ctgttgccgg tgccggtgta
     1801 gtcgacgaag tagcgccggt cgtcctcgga gagccggtag tagctggggg tgtcgatgcc
     1861 cttgaagctc agcgacggcc cgaggtggtt gccctcggcg gtgtggttgt agaccacgtc
     1921 gaggatgacc tcgatgccgg cggcgtgcag cgccttgacc atgccccgga actcctgcac
     1981 ctgctggccc aggcggccca gcgcggagta gccgtggtgc ggggcgaaga agccgatggt
     2041 gttgtagccc cagtagttgc gcagccccag gtcggccagg cggtggtcgt gcacgaactc
     2101 gtgcaccggc atcagctcca ccgccgtgac gccgagccgc ttgaagtgct cgatcatcac
     2161 cggcgaggcg atcgccgcgt acgtgccgcg cagctcctcc gggatgcccg gatggcgcat
     2221 ggtcagcccg cgcacgtggg cctcgtagat caccgagtgg tggtacgggg tgcgcggcgg
     2281 ccggtcgttg ccccagtcga agtacgggtt caccaccacc gacttcggca tgtacggcgc
     2341 cgagtcctcg gtgttcatcc ggtccgggtc gccgccgacc tcgtagtcgt acaccgacgg
     2401 gtgccacatg atctccccgt cgaccgcctt cgcgtacggg tcgagcagca gcttgtgcgg
     2461 gttgcagcgc agcccctcgg ccgggttcca cggcccgtgc acccggtatc cgtagcgctg
     2521 gccgggctcg acgccgggga tgtaggcgtg ccagacgtac gcgtcgacct cgcgcagctc
     2581 cacccggcgc tcggtgccga tgtcccactc gtcgaacagg cagagctcga tcttctccgc
     2641 cacctcggag aagatcgcga agttggtgcc catcccgtcg taggtggcgc cgagggggta
     2701 gctctcgccc ggccagacct gcatgtcgct ccttcggccc atgatcgtga gcgcagcgga
     2761 cagggggccg ccgatgcgca cgccggtgat gcccagtcgt acgcctcgtc aatccacccg
     2821 ttcggacggt aaccgaaatc cgccctcgtg gggccggatg tcacgttcgg gcccgcctgc
     2881 ggcgatcggg gccacccgtc ccggcattcc atagccgggg tcggcgaata agcaggtcac
     2941 ttcacaatag agggtcgccc gcattcattg acaccttccc ctactttatc ttctcgttac
     3001 atcggcttca cgcgatcgga gaaggaggca attgatgcgg tgattcatcg ttcgacccca
     3061 cctgacctgg gcgtctcgaa tagtggatcc cggaactacg ccgcgtcacc gcccggaatc
     3121 tttccgttcc caaccggcct tcacctgcgc gaattgacgg ttccgcctcg ctttatctcc
     3181 ctgttacatc agcgcggtgc gaatcccgcc aggaccggcc tacgcttcgt tccactgtcc
     3241 acatcgatcc gaaaagagga tgaatcgatg ggtgaaagca ggaacttgtc gatcgacctg
     3301 tccgacctgg acaccacagc ggtctcctgg tcgggcgccg gcgacgaggc gtcggcaggg
     3361 ctgtacgcca tgccgacggg cggcgggatc acgctgaccg acccgtccgc catgggcaag
     3421 ggctcctgcg gcggcgccgc gtgccagggc cggccgatcc agtggtgctg cgtcaactgc
     3481 cactgatcat cgcggagccg ccggcgatcg ccggcggctc cgtcccatcg tcagcgcggc
     3541 cggtggcccg gctcgtggga caagcggaga ggtacgtcag atgagcgttg aacccggtcg
     3601 agccgtcgag ctgagcgtgg tgatccccac ccacgcggac gccccctgcc tggagctcac
     3661 gctgcggtcg ctgcggcgtc agacgctgga cccggaccgc ttcgaggtca tcgtcgtccg
     3721 cgacggcggg gacggcagcc agtactccgg catcgccgac gccggcaagg ggctgcgcct
     3781 gcacttcgtc gaacggcccg agcgcggcgg ccgggcggcg gcccgcaacg aggccgcgcg
     3841 ccgggcgacc gcgccgctgc tgttgttcct cgacgccgac tcgtacgcca cgccggacct
     3901 gctgcgccgc cacctcgacc accaccgcga cccgtccgcg ccggcggtgc tgatgggccg
     3961 gcgcgacgag accggcatcg agcacgtgca cgcggcgctg gccgaccagc cgaccatgcc
     4021 cgtaccccgg ctgcgtgggc gcggcggcgg cgacatgcgg ttcgggaccg aggagggacc
     4081 gtccggcgac gactggctgc tggccgggtg gctgttctgc ttcacccaca acgcctcggt
     4141 gcgccgggac gtgttcgagg cggtcggcgg cttcgacgag ggcttcggcc tgcgctgggg
     4201 cctggaggac atggagctgt tctaccgggt gcacgcgcac ctcggcgtac tcaaccgcaa
     4261 cttcgcctac gacgacctgg ccgccgtcta ccacctgccg caccaccgca acgtcatcca
     4321 gaactggaac gacttcatgg acaacctgga tcgggtcgcg ctcaagtacc cggtcgtgga
     4381 gtgggagttc gccgggccgg tggacgtggc ccgcgcggcc gagcgggtgg tgcactaccg
     4441 ccgggcgatg gacgactgcg tacgccgctc ctggtgccgg atcgggccgg cggtgcagcg
     4501 gctcgccggt cgcctgcccg gcgaccgggt gctgtgggtc ggcaccggca gcgccgaggc
     4561 cgggctgccc gacggcgcgc tgacctacga ctacggggcg ccggccggtc cggccaactt
     4621 ccacctggtc gggatcaggc caccggtcgc cgcggacagc ctggacgccg tggtcagcgt
     4681 cgacttctgg cggtacctct actgggagga cctgtgccag ttcgtcaacg tcgccggtgc
     4741 cctcgccgac gaggtgcacc tggtctccac cggcgcggag ctctcggcgc ggttcgaccc
     4801 ggacccggcg agcctgggct acctcggccg ggtcatgggc gccgcgttcg agaccaccct
     4861 gaccgaggtc gacggcctcg gcacggtgct gcggctgcgc ccgcaccacc gtgccgccgt
     4921 cgcggccggc tgaccgggac gacaacgccg atgccagtga tcgaggccag tggcctgacc
     4981 aagcggttcc ggatcgccga caagcagccg ggcctgcgcg gctcgctgcg ccacctcgta
     5041 cggccacgac acgtcgagca cgtggcggtc gacggcgtcg acctgtcgat ctcctccggc
     5101 gaggcggtcg cgtacgtcgg gcccaacggc gccgggaagt cgacgacggt caagctgctc
     5161 accggcatcc tgcaccccac cgccgggcgg gtacgcgtct gcggcctcga cccgcaccgc
     5221 gaccggcacg ccaacgcccg caacatcggc gtgctgttcg gccagcgcag ccagctctgg
     5281 tgggacctgc aggtccgcga ctccctcgcg ctgctgcgcg acatccaccg catcccccgg
     5341 gcccggtacg cggcacgcct ggaggagttc gacgcgctgc tcgggctcgg ccggctgctg
     5401 ccggtggtcg cccggcagct ctcgctcggc cagcggatgc gcgccgacct ggccgccgcg
     5461 ctgctgcacg caccgcccgt ggtgttcctc gacgagccga ccatcgggct ggacatcgtc
     5521 gcccggcagg ccgtccggga cttcctgcgg gcccagcgcg cgagcgggac cacggtgctg
     5581 atgaccacgc acgacatcgg tgacatcgag caggtctgcc gccggctcgt gatcatcgac
     5641 gggggccgga tcatcttcga cggctcgatc gacgccgtcc gccggctggt cgccgaccag
     5701 cggaccgtgc acctgacgct cggcgccgac tggcacggcg acctcgacgc cgacctgccg
     5761 ggcgtccggc tggtccacga cgggtcggca cggcagatcg ccgtcacgtt cgaccacggc
     5821 gcgtacggcg cgggcgagat cgtctcggtg gtcgcccgcc gggcgccggt ggtggacatc
     5881 cggatcgacg agccgtccat cgaggacgtg gtgcgccggg cgtacgccgg cgagctgagc
     5941 ccgtcggtgc cggcatgagg gcgtacctga cgctggcgcg gatgtcctgg tcgacgctgc
     6001 tgatctaccg gggcgagttc ctcctccagc tcaccggggt cgtggtgcag acagtggcgc
     6061 tgttcgcggt ctggcaggcc gtcttcgccg gcgcggccgg cggcgaggtg ggcggattgt
     6121 cctgggagca gatgaagggc tacctggtcg tggcgttcct gaccgggggg ctgctgtcga
     6181 gcttcaccga cgcgcagatc gccggcccgg tgctgcacgg caccgtggcg ctcgacctgg
     6241 tccggccgat cgactaccag ctctcgcgtt tcgcgctgtc actcggatac gtcgtcggtg
     6301 aagtgctgac ggtggcggtg atggcggcga cgctggtgtc ggcgttcggc ggcgccgcgc
     6361 tgcccgccgc cgggcaggcc gggctgttcc tgctcagcct gctggcggtg gtgccgctga
     6421 agttcggcct ggtctacctc gtcgggctgc tgtgcttttg gaccggcaac ttccacgggc
     6481 tgagcctgtc ccgggtggcg gtcaccaaca tcctctccgg ggcgctggtg ccgatcgcgt
     6541 tgttccccgg ctggctccag gtcgtctgcc agctctcccc gttccccggc atcgtctcca
     6601 ccccggcgct gatctacctg gggcaggcac gtggcgccga ggcggtgacg ctgatcggcg
     6661 tacaactgct ctgggttctg gtgttgtggg gcgcggcccg gctgctgtgg tccgcgggcg
     6721 tgcggcggct gaccgcgcac ggcgggtgac cggccgatga tgcacgaggc acggatctac
     6781 cgccggctgc tcggcgcgca tctgcgggcg gtgctcgagt accgcgccga cgcgctcctg
     6841 accatcgggg cgacggtgct cggtcagctc gccgggctgg tcttcgtggt gatggtgttc
     6901 cggcaggtga ccgcgctcgg cgggtggacc cgctgggagg tgctgtacgt ctgcgccatg
     6961 gtgatgctcg ccgagggcgt cggctccctg ctgttcgagg ggacctggca tctcggcggc
     7021 ctggtcaacc tcggcctgct ggactacctg ctggtccggc cctacccggt ggtgctccag
     7081 gtcaccggca acgcggtcgg gttcaacggc ctcggcaacg tcggtttcgg cgcggcgctg
     7141 ctcggcgccg cggccgtcca cctcgacctg gcctggacgc cgctgacggt gctctgggcg
     7201 gtggtgctgc tcgccagcgg agtcctggtc aagctggcgg tcaacctggc caccaacgct
     7261 gtcgtcttct ggctgctgag cccgtccagc tcgctcgcgg cgagcgtgca caccctgggc
     7321 gacctggccc gctatccgct gaccctgtac ggcaccggcc tgcgctcgct gctgacgctc
     7381 gtacccgtcg cgttcgtcgg ctacttcccg acggccgcgc tgctggacaa gggcgcctcg
     7441 accacggcgg gcgcgctcac cccggtcgtc gcggcggcct gcgcggccgg ggcgtgggcg
     7501 gtcttccggg ccgggttgcg ccggtacgag agcgcgggca gctgagatgg cagccacgcg
     7561 ggccggcgtc gccggccggt acctggcggc ggtgcgggac gacaccgggc agccgacggc
     7621 gtacctgccg ccgtgcggca agcggtaccc gggcgcgacc cgccggccgc tgcggtggcc
     7681 cggcccgggg tccgtgccgc tcggcgacgg ctgcctcgac cggctcagcg cgatgctgct
     7741 cgggtacgcg ccacgccggg cggagacgat cacgctggcc ggactgtccg cgttgaccgg
     7801 cgccccgtcg gacacgccca cgccgtcgcg gctgctgccc ggctggcaca cgctgcgccg
     7861 gtcggtgccc tccggcgggg cgttccaccc caacgagatc tacctcgcct gggccggctc
     7921 ccccgacctc gcggccggcg tctaccacta cgacccgccg caccactgcc tggaactgct
     7981 gcgcccgggc agcccggccg cccggctcga ccggctcctc ggggtcgcgg cggcgccccg
     8041 gcacgcgctg ctgctgaccc accggccgtg gaagaacacc agcaagtacg gggcgttcgg
     8101 ctaccggctg ggcatcgtcg actccggtgt cctgctggcc cagctgctca cgtcgccggt
     8161 ggacgcgaca ccgcgcctgg acctcgatcc ggcgctcgcc ggtgagctgc tcggactcga
     8221 cgccgaactg gaggccctct acgcggcgat cgagttcccc gcgcacgcgg acgtccccgg
     8281 gacaccgctt gcgtccggcg ggccgccccc ggcgaccggg ctggaccacg accggctcgg
     8341 ccacgaggcc gcccacccga gcgcggtggc gctgcaccgg gcaaggtacg accggcacgc
     8401 cgacgccgag ccaccctcgg ccggccgtct tccggccgac ggcgtcccgg cccagcgcct
     8461 cccggcggac cgccttccgg tgggtccggc ggcgggccgg gcgctggacc tgccgccggc
     8521 ccggccgctc gacctggtcg cggcagccgc ccgccgcgcc tccgccgcga acctcggccc
     8581 ggggctgacc gccgggcagg tcgccgacat cctggcctgc gccgccggcc gggccggttc
     8641 gccggccctg gcggcgctgg cccggcagcc gctgtacccg gagctctggt gcctcgcccg
     8701 gaccgtcgac ggcatcccgg cggacgcgta ccgctaccag ccgcaccacc accggctggt
     8761 gccgaccggg ccgccgggag cggccgacga cgcggcggcg tacccgcacc gggtcgaccg
     8821 ccggatggtc acccgcggcg cgaccctcta cctggtgcac gccgggagcc ggcccgtcga
     8881 ccagctctcc ccggcctcgt tccaccggct gcacctgctc gccggtgtgg cccttcacct
     8941 ggccgggctc gccgccaccg cgaccggcgc ggcgagccgg gcgctgggcg gcctcaccgc
     9001 cgacgccgtc gccgcccggc tcggcctgcc ggacggggcg tccccgctga cacaactgct
     9061 ggtcggcacg cccgcgccgc gtcccggggc gctggcggcc catctcaccg aagggaaccc
     9121 tcatggctga acaggacgtt ccggcgctcg tcggcacccc cacgccggac gcggtgctcg
     9181 cggcggtcgc cgagcacggc gcggtgctgc tgcgcggcgg gtggcggcac gaggactacg
     9241 tcgcgctcgg cgacgcgctg atgaccgcgt cgccgtacca gggcgggttc cacgacgagc
     9301 gggacgtgat cggcggtgac ccgacgacga ccacagtcac ccggggaacg cagggcatgc
     9361 cgctgcaccg ggaggcgtcg tacgcgcccg gcgccccgga cctgctgatg ttccggtgcg
     9421 agcggcccgc cgccgacggc ggggccacga cgctgtgcga cggtctcgcg ctgctggccg
     9481 ccctgcccgc cacggtccgc gccgcctgcg aggaactgac gctgcgctgg gagagcgagc
     9541 tgcccacacc ggtgtggcag cggatgtgcg gcacgaccga cccggaggcg gcggagcgga
     9601 tgctgcggca gtgggagccg tacctgcggc cgtgggagtc gatccacatc gacgtggacg
     9661 aggacgcgat gactgtcggc ttcggcaccc ggtgcacgcc accgaccctc ttcgaaggtg
     9721 tgccggcgtt ctgcaactcg ctgttcatca gccgcccgca gcccggcgag taccacgacc
     9781 ggcggctgcg ggtgcgctcc ggtaccggcg cgccggtgcc cgaggacctc gtggccaccg
     9841 ccgcggacgt cgccgcgcgg ctgacggtgg cggtgccgtg gcggtccggt gacgtgctgg
     9901 tcgtggacaa ctcccggtac ctgcacggcc ggcaggcgtt caccgacgcc ggacgcgcgg
     9961 tcgcggtgcg gatgggacac ctgcggaagg agacggccgc gtgagggtca agctccgcga
    10021 cgacctgatg tacgtgccgg tcgacgacgg cgtgtacctg gagacgggac tcgccggcac
    10081 gcacctggcg ggcgcgtcgg cgtacggcct cgtgcagcgg ctcgccccgc atctggacgg
    10141 cacccgcacg gtggaggcgc tgaccgcggg tctgcccccg gcgcagcggc agctcgtcac
    10201 cgacctggtc cggatgctgg tgcggcgggg catcgcccgc gacctcgaca gcgagccgcc
    10261 acacacgttg cgggactggg aactcgacac ctaccgggac tcgatcgcgt tcgccgagca
    10321 cgtcaccgac gcgccgctga gccgcttcga ggcgttccgc gacgggcggg tgctgctcgt
    10381 cggcgccggc gccggcatgc tcgcgctcgt ccagacgctg ttcgaactcg ggctgcgtac
    10441 ggcctcgctg gtcgagacca ccgagaccgg caccgaacgc gacggcttcc ggcggatcgt
    10501 gcagcggcgt cgagccgagg atccgacgac cgggctgacg ctgctggacg cggccgccgc
    10561 cctcgacacc gacgaggggc tcgccggcct gctgacgggg tacgacgcgg tgctgcactg
    10621 cgccgcgcgt ccgatggccg ggcgggcgac gcggctgaac cgggcggccc gggcgatcgg
    10681 ggtgccggtc ctgcacgcgg tgcccggcgg cgcggaggcg tggatcggcc cgaccggcgg
    10741 cggcgtcacc ggcggctgct gggagtgcgg cctgctcagc cggcagggcg ccgggctccc
    10801 cccgggtgac gccgacgagc ccgacacgac gtccgagtgg ctgtcggcgc cggtctgcgg
    10861 cctgatcggc gcggcgctcg ggttcgcgta cctgcgccac cgcgtgggag cggagaccac
    10921 cgccacgaac cggatgaccc gcgtggacct ggaaaccgct gtgaccagcg agcatctgct
    10981 cgacgtgcac ccccgctgcc gctcctgccg gcccccggcc ccgtacgccg atctcgccgc
    11041 gcacgtcgac gcgatggccg cccgcacgcc ggtgggcgtc gaggagttcg tcgcccggat
    11101 gccgttcctg gtcgacgcgc ggctgggccc gctgctggcc atcgacaccg gcgcccactc
    11161 gcagatctcg gtcagctgcg tcgaggcgac ggtcgtggac ctggccggcg gcgcaccgcg
    11221 gctgctcacc gccgtcggcg caagccggga gcaggcgctg ctgcgcgccg ccacggcggc
    11281 actggagacg ctcgcggcgc gggcctgcgc cggcgacacc gccacggtgt ggtgggacac
    11341 cgcgcgtggc gctgtcgtcg acgcacagcc ggacggcgtg gtgatcgccg gcggtcacac
    11401 ctgggcggag gcgcgcggcc gggcgatcct gaaactgcga cgcgcggccg cgaccccacc
    11461 cgaggtcgcc gacggtgggc cgcccggtgg ctggctcgac cgggcgcggt ggccggagcc
    11521 gacccgcgtc atggcacacg agctggccct cctcggccac gagccgcggg cgtggcacga
    11581 cggatcgagc accccgaccg tgttcgtcgc cgtcggcggc ggatgggtcg cccgcagctg
    11641 cgccaccgac acggacaccg ccctggcgaa cgcgatgcag gcggcggtcg ccgtcctgac
    11701 cggacgccgc ccggacggcg ccgagatcgg gccggacgtg ggcggccacg actgggatac
    11761 ggcgctgccg ccgctgctgc gcgagctggc acgggacgga cggtcgctgc tggtgcggcc
    11821 cgccgactcg ctgcccgggg cgcagcgggt gatgccgttc atgatcaggg cggcgtggtc
    11881 gccacgagcg gggagcagcg catgaccgac gtcacgacca caccggccgt ccccgccccg
    11941 tccgacgtgg cgccgcgtcc cggcctgcgg atcctcggcg tcggcgccct gcgccgggcg
    12001 gtggaacagg cgctgggcgc cgccccggtc accgacgtcg acgtcttcgt cgtcgacggg
    12061 ccaccggagg acgtcgacgt ggccgcccgg gctgccgccg acgccggccg gtccttcctg
    12121 ccggtgtaca ccacgccgcg cggcgtacgg atcggaccgt tcgtcacacc cggccggccg
    12181 ggctgccacc actgcctcca ggtgcggcaa cgccgggcgc ggaccaccgg gacaccgcac
    12241 cggtccgcgc tgtggcaggg gctctacgac ggcaccgtgc agcccgcccg gcccgtcctc
    12301 ggcccgccgg tacgcgccgc ggtcgccgcg ctcgtggccg acgagctgag ccgggtcgcg
    12361 cagggcggcg acggccggtg cgcggaagcg gtgctggagg tcgccacggc ctcgatggcc
    12421 gtcaagcggc accggttcgt ccccgaaccc ggctgcccgg tgtgcggccc gttgccggac
    12481 gacggcccgg gcgccggcac cttcacgctg acgtcccggc cgaagcgggc accggacgac
    12541 taccgggccc gcagccttcc cgacgagcac ctagccctgc tggcggcgct gcacgacgag
    12601 gagaccgggc tgctgtcgtc gatcaccgtc caccacaacc atccgatggt cctcgccggc
    12661 gcgatcggtg gcccgttgtg ctgtggtgaa ctggccggct acggccggac cttcacctac
    12721 ccggcgagcg tggccgtcgc cgtcgccgag gcgctggaac ggctcggcgg caacgtgcca
    12781 cgcgcccgcc gtaccgtcac ccgcgcctcg ttccgcgagc tcggaccgcg gcgggccgtc
    12841 gagccgacgg agttcgggct gccgcccgcg ccgcccgacg accacgcggt cgcatacgac
    12901 ccggaccggc ccgtggaatg ggtgtacgcc tactcgttcc ggcgcggcgg cccggtgctg
    12961 gtgccggaga ccttcgccta ctacggctcg cacggcacgg gtttcggtcc ggagtgctca
    13021 aacggctgcg cgctgggcgc gaacctcgaa gaggcgatcc tgcacggcat cttcgaagtc
    13081 gccgaacggg acgccttcct gtccacctgg tacgcccggc taccggtgcc gcgcgtggac
    13141 ccgatgacct ccgccgaccc gatgacccgc gtgctcgtcg actggatcca gcgcaccacc
    13201 ggcagccgcc tggacgtctt cgacatcacc atgcccgaag gcgtcccggc ggtctggctg
    13261 atgctcgtcg acgaggaggt gcggccggga cgtccccggg cgttctgcgg cgccggggcg
    13321 cacctggacc cggagcgcgc cctgtggtcc gcgctggtgg agctcgccag cgtcgccgag
    13381 gccacccggg agatggtcgc cgaggacacc accgcccccg gcctggtcgc cgactccgac
    13441 ctggtccgga ccatggagga ccacctgctg gcggcggccg acccggacgc ctggccgcgc
    13501 ttcgcgttcc tgtacgagcg cgacgagatc cggtccatgg cggaggcgtt cccaccggcg
    13561 gcgcgctacc gcccggccgc ggacctgctc gacgacctgc ggcacgtgac cggccgctac
    13621 ctcgacgagg gcctggacgt ggtggtcgtc gaccagaccg cccgcgagca ggaggccgtc
    13681 ggcctcacca gcgtgaaggt gctgatcccg gggctgctgc cgatgacgtt cggtcaccgc
    13741 aaccggcgcg tcgacctgcc ccggctgcgc gagctgccgg tccggctcgg acaccgggcc
    13801 gaaccgctcg ccccggagga gatcaacccg tatccgcacc cgttcccgtg accgtcccat
    13861 gtgcgcggag gcgtcggaga gtgatgagga tcgctcaccg cgcgcgagag gatccggcac
    13921 agtaggttgg cagggtgact ggacggttcc ggttgccgat cgacgtcagc accctcccgg
    13981 tggcccgcga tcggtatccg gccaggccgt cgtcggcgag ctggtgccgg cgcccggccg
    14041 gccgtccggt cgctcctgac caccgctcga cgccgccacc gctgccggcg tgcctcaccc
    14101 tgcatggacg gagatcgacg tgaccactct gcgggtcggc gcgcagcccg ccaccgcgac
    14161 ggaccggctc caccggccca ctctcacctc ccgcccggcc ccgccgtcgc cggccggggc
    14221 cgggccccgg acccggcgca tcctgatgct gtcgtgggag tacccgccgg tgctcgtcgg
    14281 cgggctcggc cgccacgtcc acgcgctgtc cgtggcgctg gccgccgccg ggcacgaggt
    14341 cacggtcgtc acccgccacg ccgagggcgc tcccctggag gagtacgccg acggcgtccg
    14401 tatcgtccgc gccgctgagg acccggtcac cttccccctg gccaccgggt cactgctggc
    14461 ctggacgatg gcgttcaacc acacgctgac gcgggccgcg ctgcgcgccg cctcgtccgg
    14521 cgcctacgac gtcatccacg cccacgactg gctcgtcgcg cacaccgcga tgacgctgcg
    14581 cgagcacctg gacgtgccgc tcgtgaccac catccacgcc accgaggcgg gccggcacca
    14641 gggctggctg ccggaggaga tgaaccgcac catccacggc gtcgagcact ggctcgccgg
    14701 cgagtccggg cgcgtgatcg tgtgctccgg ctacatgcgc gacgaggtgg gcgcgctgtt
    14761 cggcgtggac gccgcccgcg tcgacgtggt gcccaacggc gtcgagccgc accgctggcg
    14821 ggtgcccgcg tcggcggtcg ccgccgcccg ggcgcggttc gccgccgacg gcccgctggt
    14881 cacgttcgcc ggccgcctgg tgtacgaaaa gggcgtacag cacctgctgg ccgggctgcc
    14941 ccggctgcgc gaccggcacc ccggcctgcg cgcggtgatc gtcggcgacg ggccgtaccg
    15001 ggcggacctg gaggccgagg tgcaccgcct cgggctgggc ggcacagtca gcatgcccgg
    15061 gttcctcggc ggcgccgacc tgcccgcggt gatggccgcc tcggactgct tcgcggtgcc
    15121 cagcatctac gagccgttcg gcatggtggc gctggagggg gccgccgcgg gcgcgccgct
    15181 ggcagtggcc cgcaccggcg gcctggccga gatcgtcgag ccgggcgtca ccgggatgac
    15241 gttcgccccg cacgacccgg acgggctcgt cgaggcggtg cacgcgctgc tgtcggaccg
    15301 ggaccgggcc cgcgtgctcg cccggcgggc ccgcgccatg gtccacgagc ggtacggctg
    15361 ggcggccatc gcgtcccgca cggctgccgc gtacgccgcc gcgatcgccg gcgacccgtc
    15421 gttcaccgcc gcccgcgccc agcaccgcat gacacacggc cggcccacgc cgcgcgtccc
    15481 cgagggcaac ctcctcaccg ccgccggcct gcggtgaagg aagggccccc tgttaacgcc
    15541 tgcggtagag gaagggcccc ttcttaacgc cccgcacccc cgcgcacgcg acgaaggccg
    15601 ccgaccctgc tcgggtcggc ggccttcgtg gcccgcgtgt taaaaggggg cccctcctct
    15661 accggaggcg ttaagaaggg gcccttcctt gcacgctcag cgctggtcgg cggggacgta
    15721 cgcccgctcg gtggcgccgg tgtagatctg ccgcgggcga ccgatcttgg tctccgggtc
    15781 gttgatcatc tcgcgccact gtgcgatcca gccgggcagg cggcccagcg cgaacagcac
    15841 cgtgaacatc ttcgtcggga agcccatggc cttgtagatc aggccggtgt agaagtccac
    15901 gttcgggtag agccggcggg acacgaagaa gtcgtcggcg agcgcgatct cctccagctg
    15961 caccgcgagg tcgagcagcg ggtccggctt ggacatccgg ccgagcacgt cctgggcggc
    16021 cttcttcacg atggcggcac gcgggtcgta gttcttgtag acccggtgcc cgaagcccat
    16081 cagcttcacg ccgtcctgct tgtccttcac cttctgcacg aaggagcgga cgtcgccgcc
    16141 gtcggcctgg atcttctgga gcatctccag cacggcctgg ttggcgccgc cgtgcagcgg
    16201 gccgaacagc gcgttcacgc cggccgagac cgaggcgaac aggttggcgt tgctggagcc
    16261 gaccagccgc acggtggagg tggagcagtt ctgctcgtgg tcggcgtgca ggatgaacag
    16321 catgtccagc acccgggcca ccaccgggtc gacctcgtac ggctcggccg gcacaccgaa
    16381 cgtcatccgc aggaagttct cgacgtagcc gagcgagttg tccgggtaca gcagcggctg
    16441 cccgatcgac ttcttgtacg cgtacgaggc gatggtcggg accttcgcca tcagccgcac
    16501 cgtggacatc tccacgtgct cggagtcgaa cgggtccagg ctgtcctggt agaaggtgga
    16561 gatggcgctg acggccgagg agagcacggc catcgggtgc gcgtcacggg ggaagccgtc
    16621 gaagaaccgg cgcatctcct cgtgcagcag cgagtgccgc cggatccgct cgctgaactc
    16681 cgacagctgc gcctgggtcg gcagctcgcc gtagatcagc aggtaggaga cctccaggaa
    16741 ggaggacttc tcggccaact ggtcgatcgg gtaaccccgg taccgcagga tgccggcatc
    16801 accgtcgatg taggtgatgg cggacgagca ggacgcggtg ttcacgaaac cggggtcgta
    16861 cgtggtcatc ccggtttcct tgagcagctt gctcaccccg atcccggcgg ggccctcaac
    16921 cgcggactgc accggcatcg acagctgccc accggggtgg tcgagcttga cttccgtcat
    16981 ctgttcctcg cttcgccggc aagatcttcg ttgaattgcc ttcgcttcta ccgtaatcac
    17041 ggcgcggaga acaccgctcg tcatggtttc ggggtgaggt gtgcgtcacc tgtttcccgg
    17101 ccaggcggtc cggaaaccgg ttgggagcgc gaccatgggc gccggccagg ggcccgtcac
    17161 gacagcgtga gccgccgcag cgccccgtcg tcgccgaccc ggtagaggtc gagccggttg
    17221 gcgccggcgg cgaagagccg gtcgtcgggg aggaacgccg cgaaccgccg gccaccggcg
    17281 tccgggggca ccaccggcgc caccgccccg accgtgccgt tcaccgcgac ggcgagccgt
    17341 gtcccgtcgg gcacgtcgtc cgggaccgtc ccccagacca gcgcgggcag gccgccgcgc
    17401 gccgggtcga ccgcgtcgaa cgcgtcccgg ttcgccaccg tggcggaccc gcccatcggc
    17461 acgttcccga cccgggtccc gacgagcgga tcagcggccg gcggcgggag cggggcgggc
    17521 accccgccgg tgatcgtcac cggctggccg gggcggtcgt agaagcgttt gtcggctcgc
    17581 tcgcgcggag ccgccttggc cgaccggccg tccatctgcc agggcacccg catgtgggtc
    17641 tcgtcggcga tcgtgggcag caggtccacg tgctcccagt tgcggtcgtc cacccggccg
    17701 gcgcgctggc cgggttcctt gacgaacatc ggcacccagg ccacctcgtt ggcggcgtgc
    17761 tcgatggcgt ccatcccccg cccctgccag tcccgccgga agctcacccc gtggtcggcg
    17821 gtgaccacca ccagcgcctt gtcgtagagg ccggtggcgc gcagcgtccg cagcgtctcg
    17881 ccgatcagcc ggtcggtgta gccgagctgg gccaggtgcc gggcgcgggc caggtcgacc
    17941 cagccggtcc cgtcgttggg caggtcctcc ggcgcgaagt agtgcgcccc ggacggcagg
    18001 tacgcccacg gcgagtgcgg catcagcagg tgcaggaagt gcagcgtggg ccgggggtcg
    18061 gggcgcagcc cggccaggaa cgaggtgaac cgggccggct ggttgtcgtc gagggtgtcc
    18121 cagcggaact tggggtcgtc cggcaccggc tcggcggcgt ccagcccggc ctcggcggcg
    18181 gtccgctcgc ggtaggagtc ctccgggtcg acgcggctgt ccaccggcgc ggcgatccgg
    18241 cccatcagct tgccgctctc ccggaccagc accccgagcc cctgttccgg cgtggtggcc
    18301 tgctcgcagc ggctcggcgg acagagccgg gtgatgctct cctcggcctt gatccggtag
    18361 aggcccccga gcgcggtgaa caggttgtcc gggtactgcg agtagtgcgg cgccgcgccc
    18421 tgctccgggt agcgcccggt gagcatcgcc ggcagcgcgt agggcgtcca gccgctgacg
    18481 ccggtcgcgt tggggtacca cgtcgacccg gccgcgagcg cggcgaagtt cgggtagcgt
    18541 tcggcgtcga tgcgtccgtc cgggccgagc agcgagacca gcggcagctc gtccagcacg
    18601 atcatgacca ccggcgggtg cgcgcccgcg ccggcgatcc cggccgcgcc gccctcgccg
    18661 cgcggcagca ccaccgccga ggcgggcgag gcgaacagga acaacccgac gaacaccagc
    18721 ggcccggcgg cggccacccg cagcacccgc cggggcgccc gccaccgccg gtgcgcggcc
    18781 gccccggcgg ctccggccac accggcggcg acgagcaggg gtacgccccg gagcggcgtg
    18841 acgtgccggc cggcctggac ggccagcgcg gcgagcagca ggccgacgaa ggtggtgtgc
    18901 acggcggccc ggataaggcg tccggcgggc actgccagcg cgccgagcag cgcgaacggt
    18961 accgtcggcg cgagcgcgat cagggcgacc aggagcagca cgtcgccccg ggacgcgcgg
    19021 tggaacagga agaagtcggg gctgcggccg agcacgtcga gcagcggctg ggtcaccacc
    19081 agcccgacca gcgcggtcac ctccgccagc cgcgcaagct cggaccgcca ccagggcggg
    19141 cgttcccgcc ggtccgggcc ggccgtgtgg tcccggggtg gcgcgagggt gcgctcagcc
    19201 acccaccacc acctggtaga gcgtccgggt gccggacggc agctcggtgc gggcgaccac
    19261 ccggccccgg cgggccagca gcgcctcgaa ggcgtcgcgc cggtagtccg ggaacaggcc
    19321 gtcgggcttg ttggcgagca ggcggcgggc catcggatcg tccgggtgga cgaactccac
    19381 caccaggctg ccgccggtgg cggtgagcgc ggtgagctgg tccagcacct cgggcagcgg
    19441 cacgttgcgc ccgatcgcca ggtggtgcac gacggccagg gcgagcacca cgtcggcgcg
    19501 ggcccggtcg gcgaacgcgg cccgctcgac gccgcgccag ccgccgccgg gcgacgggtc
    19561 ggccaggtcc atcaccagcg gcaggatccg cgtctcgccc tcgtcgcgca gcgcgcggta
    19621 gagcgtgtcg accaccgccg ggtcctgctc gaccgcgacg acgtgcgcgg cgtgccgggc
    19681 ggcgatgcgg gcgtaccggc cgtcgttggc gcccaggtcc agcgccgagc cgccgccggt
    19741 ggcggccacc gcgcggtcga cgaactcctc cttggcctgc cggtccggca ccgagtacgc
    19801 gcaggtgcgc tggtagtccg cccagtggct gtcgccgggc cggtggtcga ggcggcggac
    19861 cagtttcgtc agcccgcgta ccgtggccag cgccagttcg cgggagaagc cggcggcgcg
    19921 caactgggcg cggacgtcgg tggtgctcgc ggcggagttg cgggcctgca tcgcgccgtg
    19981 caggtgcacg tgggtgggca cgccggcgcg ccagcgccgg gcgccgccga acagccggcg
    20041 catctggtcc ggctcgacgc cgtcgacgcg ggcccgcagg aacggctgga agtccagccc
    20101 gaggtgggcc tggatcagca gcgggtagag cagcgtctgg cagaactgcc ggtagccggc
    20161 ccagggttcg ccgtcgcgca gcgcctcgaa cgagccgacg tcgatgaaga cgggtcgcgc
    20221 gccgcgccac tgcacgttgt acgccgagcc gtccttggtg gtgaagccgg cctccagggc
    20281 ggcgcgcagc acgtcgaggt gcagcaacgc ggcgtcgcgc agcatcgcgt acgaccactc
    20341 gtaggggtgc gagacgaacg ggatccgctc gtgccgcagc accgccgccc actgcgtgtc
    20401 gacgggggtc ggggtcagct cctcggtggc gacgatctgc ccccgctcgg ccgcgcggcg
    20461 gaagaagtcg gtgacggaca gcgcacgcca gtcccgggcg gagcgctcgt cgagcccgcg
    20521 cagcacctcc tcgccccggt ggaacacccg gttgccgggg tcgcggaagg agccgggctc
    20581 gacgcggacg ccggtgtcgg ggaccgtcac gccgtggggc cctggtcgct gggctgacgg
    20641 cggaaccggg acaccaggcg gcgccagtag agcttggcgg ccacggccac tccggccacg
    20701 ccgccgacca ccgcctgcac gatgagactg cccgatcccg cgtccaggta ggccaggtgg
    20761 gtcacggctg cttccttccg tcgccggtcg tcagtgcgcg cccggaatgc gagctttcgt
    20821 gcttcgcgcc ggacttgtcc cccaccgtaa cgcctcgggc gtcgcacgcg gggccacacc
    20881 ggccactcgt cccccgtccg atccgttcaa gacgggccgg accggtcgcg cctaccgtga
    20941 cgccatgaca ccgcagttcg atctggtcgg ggccgtggtc accgacatgg cccgcacact
    21001 cgacttctac cggcggctgg ggctgccgat cccggccggc gccgagacgg aagggcacgt
    21061 ggaggtcacc ctgccgaacg gcgtacggct ggcctgggac acggtcgagg tgatccgcag
    21121 cttccacccc gacttcgacc cgtccggcgg caacaaccgg atgagcctgg ccttccggtg
    21181 cgccgacccg gccgaggtgg accgctggta cgccgagctg accgccgccg gccaccacgg
    21241 ggagctgccc ccgtgggacg cgttctgggg ccagcggtac gcggtcctgc acgacccgga
    21301 cggcaacggc gtggacctgt tcgccccgct gccggcgggc gactgaaagg cggccggtca
    21361 ggcggtggtc ggggcgagca gccgcgacgg gggcagcccg gccagctccc gcacctcgcg
    21421 ggtcaggtgg gcctgatcgg cgtacccgct gcgcgcggcc acctcggcga gcggcgcgcc
    21481 ggcgcgggcc aggtccagcg cccggcgcat ccgcaggatg cgggcgagcg tcttcgggcc
    21541 gtacccgaac agggtcaggc tgcggcggtg cagggcccgc gcgccgaggc cgacctcggc
    21601 ggcggtcgcg gcgacggtgg ccccggcggc caggcgggcg gcgacacgcg cgccgaccgg
    21661 gtcggggccg ccggccgcac gcagccggtc gcgggcgacc cgggtgagca ccccggcggc
    21721 gctaccggcg cccggcgcgg ccagcgccgc ctcgacccgc tcggtcacct cggcggcggc
    21781 gcggccccac aggtcggcca gcgggacgcg gcggtcgcgc agttcctcgg cgggcacgcc
    21841 gaacacggcc gggccggtgc ccggcggcag gcgcagcccg atccaccggt cccccggcgc
    21901 ggacc
//
