LOCUS       NZ_BBVA01000002        22616 bp    DNA     linear   CON 10-SEP-2024
DEFINITION  Micromonospora sp. NBRC 110037, whole genome shotgun sequence.
ACCESSION   NZ_BBVA01000002
VERSION     NZ_BBVA01000002.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Micromonospora sp. NBRC 110037
  ORGANISM  Micromonospora sp. NBRC 110037
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Igarashi,Y., Komaki,H., Ichikawa,N., Hosoyama,A. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Micromonospora sp. NBRC 110037
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2438518)
  AUTHORS   Hosoyama,A., Ichikawa,N., Kimura,A., Ohshita,R. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 106x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001652995.1-RS_2024_09_10
            Annotation Date                   :: 09/10/2024 02:06:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,195
            CDSs (total)                      :: 6,136
            Genes (coding)                    :: 6,073
            CDSs (with protein)               :: 6,073
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 15 of 63
            Pseudo Genes (incomplete)         :: 53 of 63
            Pseudo Genes (internal stop)      :: 4 of 63
            Pseudo Genes (multiple problems)  :: 9 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1599923
            Orig. end                         :: 1622539
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBVA01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22616
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="10"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22616
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22616
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12616](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12616)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(10..957)
                     /gene="pip"
                     /locus_tag="A4R25_RS06300"
     CDS             complement(10..957)
                     /EC_number="3.4.11.5"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030163 - protein catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (34-295). E-value:
                     3.5e-30. Score: 97.3. Matches aSDomain:
                     nrpspksdomains_A4R25_RS06300_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="pip"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018784298.1"
                     /locus_tag="A4R25_RS06300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="prolyl aminopeptidase"
                     /protein_id="WP_064445947.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-10, bitscore:
                     38.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.3e-27, bitscore: 92.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYPPIEPYAQGMLDVGDGQRVYWETCGNPDGRPALVVHGGPGSGA
                     GAGWRRLFDPAAYRIVLFDQRGCGRSTPLASDPATDLSVNTTAHLLADMEALRAHLGID
                     RWLLCGASWGSSLALAYAQRHPQRVTALVLFSVVANTSREIEWLTRDMGRVFPQEWARF
                     RDGVPEADRDGDLSAAYARLLDDPDPAVRERAARDWCDWEDVHVSLAGGYAPDPRFADP
                     VFRYGFARLVTHYFANRGFQPDGQVLRDAGRLAGIPGVLVQGRLDVSGPPDIAWLLTRD
                     WPDARLEIVESGGHGGGHGIGERVVAALDAFAAG"
     aSDomain        complement(73..855)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS06300_Abhydrolase_1.1"
                     /evalue="3.50E-30"
                     /label="A4R25_RS06300_Abhydrolase_1.1"
                     /locus_tag="A4R25_RS06300"
                     /protein_end="295"
                     /protein_start="34"
                     /score="97.3"
                     /tool="antismash"
                     /translation="LVVHGGPGSGAGAGWRRLFDPAAYRIVLFDQRGCGRSTPLASDPA
                     TDLSVNTTAHLLADMEALRAHLGIDRWLLCGASWGSSLALAYAQRHPQRVTALVLFSVV
                     ANTSREIEWLTRDMGRVFPQEWARFRDGVPEADRDGDLSAAYARLLDDPDPAVRERAAR
                     DWCDWEDVHVSLAGGYAPDPRFADPVFRYGFARLVTHYFANRGFQPDGQVLRDAGRLAG
                     IPGVLVQGRLDVSGPPDIAWLLTRDWPDARLEIVESGGH"
     gene            1057..1566
                     /gene="def"
                     /locus_tag="A4R25_RS06305"
     CDS             1057..1566
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018805352.1"
                     /locus_tag="A4R25_RS06305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide deformylase"
                     /protein_id="WP_064445948.1"
                     /transl_table=11
                     /translation="MTMRPIRIIGDPVLRTPSEPVTSFDAELRALVTDLMDTLLGAPGR
                     AGVAAPQIGVNAQVFVYDADGRRGHMINPTLELSDELQDDDEGCLSIPGLYFPTPRALH
                     ATAHGYDQHGEPLTITGSGFLARALQHETDHLRGRLYVDTLRGDTRRRALREIRAGRFD
                     SPSRGR"
     gene            complement(1546..2349)
                     /locus_tag="A4R25_RS32015"
     CDS             complement(1546..2349)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476772.1"
                     /locus_tag="A4R25_RS32015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_064445949.1"
                     /transl_table=11
                     /translation="MVGGLIAVAVRAEHDRAVLAGLLGRDPVLHAYQLGDLDDFFWPYT
                     SWFRRGDQVVLLYHGVELPTLLAFAAPDRVPELAGLLAEAAPVLPARMWAHLSPGLEAV
                     VGRWFVVSEAAAHHRMALTDPGRLAAAPAVGEPLGPADAAELSGLYAVAYPGNWFDPRM
                     LDTGQYVGVREDGRLVAVAGVHVFSPRWRVAALGNVTTHPDVRGRGLGAGVVAALCARL
                     RTSVDHVTLNVRADNAAAVRLYERLGFSRVAGFTECALTSAAAAG"
     gene            complement(2334..3104)
                     /locus_tag="A4R25_RS06315"
     CDS             complement(2334..3104)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460321.1"
                     /locus_tag="A4R25_RS06315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TSUP family transporter"
                     /protein_id="WP_176722890.1"
                     /transl_table=11
                     /translation="MDALSLTTLLTAALVAGWVDAVVGGGGLLLLPALLVAAPGVPVAT
                     ALGTNKLAAIFGTSTAAVTYARRTKLDWGVAGPAAGLAVLTAGLGAALAGAVPGGAYRP
                     VVLVVLVAVAVFVMARPSLGVVSSPRRTPGRVVVAVAVAGLGIALYDGLIGPGTGTFLV
                     LAFTAILGSDFVHASAMAKVVNAGTNLGALVVFGLTGHVWWALGAAMAVCNVVGAAVGA
                     RMALRRGAGFVRVVLLVVVLALVARLGYDQWLAG"
     gene            3279..4058
                     /locus_tag="A4R25_RS06320"
     CDS             3279..4058
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018813262.1"
                     /locus_tag="A4R25_RS06320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_064445950.1"
                     /transl_table=11
                     /translation="MRLATFNLLHGRSLTDGLVDPDRLTAAVTALDADVLALQEVDRDQ
                     TRSGKLDLTALAARALHADHHRFAAAVVGTPGEQFRPLTHDDDGHGEPLYGIGLISRHP
                     VRSWQVTRLRAAPVRSPIYAPGPGGGLILLRDEPRVVLAAVLDTPHGPLTVAATHLSFV
                     PGWNIWQLRRVIRALRTLPAPRILLGDLNLPAGPAAALTRWRPLARRPTYPAGQPRVQL
                     DHILADRHALDRLPPVTAVHTPLATISDHRPLVVDLG"
     gene            complement(4062..4928)
                     /locus_tag="A4R25_RS06325"
     CDS             complement(4062..4928)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476775.1"
                     /locus_tag="A4R25_RS06325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional 5,10-methylenetetrahydrofolate
                     dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="WP_064445951.1"
                     /transl_table=11
                     /translation="MSSARLLPGAPVAERVLSEVAASVAELRAAGVTPALATVLVGDDD
                     ASAGYIRIKQRQAAELGFVSPHVHLPASASQADLHAVLADFNADATVHGVLVQYPIPGH
                     LDYDRALAVLDPDKDVDGMHPVNMGRLALGLPGPLPCTPAGIEALLAFHGVPVAGREVV
                     ILGRGATLGRPLAMLLAQKRPTANAAVTVVHTGVADWPRYTRRAEILIAAAGVPGIVRP
                     EHVRPGAVVVGGGVRYEGRRLLPDVDESCAEVAGAITPRVGGVGPTTVAMLFRNAVDAA
                     RRQAGLG"
     gene            complement(5022..6053)
                     /locus_tag="A4R25_RS06330"
     CDS             complement(5022..6053)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286355.1"
                     /locus_tag="A4R25_RS06330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_064445952.1"
                     /transl_table=11
                     /translation="MRVGAARAVAAGWVRERMRVDPAIEGAFFSGSTVGLPDDALLPRW
                     SDVDVLLVRREPGVKVGKFVYRGVLLEVSTITWAELGGPEDVLGSWVFAPMLRTDGVIA
                     DPSGRLSAVRERVAAGFADPVWVRARCAGVRRRIEAGLWAVDAELPTAEQVLAWVFPTS
                     LLAVWPAVAGLVDPTVRRRYVRAERVLSRFGFAGRYPGLLDTLDGGGAGVDVARVRAHL
                     AGLAVVFDEVARLPREGFAFGADLGAAGRPVVFDGAVELIGAGRHREAMFWVLVTYARC
                     HVVLGAVAPERERALRPAFQAVLADLGVASAADRRRRADGLLAALPGWQVVVDAVAAEA
                     VAG"
     gene            complement(6094..7092)
                     /locus_tag="A4R25_RS06335"
     CDS             complement(6094..7092)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476777.1"
                     /locus_tag="A4R25_RS06335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_064445953.1"
                     /transl_table=11
                     /translation="MHDKPDETVGALIEEFLTARATRKPSPHTLAAYRRDLTAVAELIA
                     ADGDATPLPLDRVAVSSLSPRVMRAAFARFAAPRAAASVHRAWSTWNSFFTFLVAEGVV
                     PGNPMPAVGRPRTPLPRPKPLRGEDTPEELLAAVARAEGRQRDPWPERDLAVLALALCA
                     GLRLSELLALRVSSVAGRDGERRVDVAGKGGRPRTVPIEDAVDRVLTGYLDSRRLRFGA
                     RSVRPDSAFLVDRQGEALRRGGLQYLVESCYRRAGIGDRVPRGARLHALRHTFATRLAE
                     DGASAAEIMRLLGHASLASSQTYIEVTAGQQRAAVAANRTNRALSGLAPRR"
     misc_feature    7100..7115
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.89"
                     /tool="antismash"
     misc_feature    7520..7536
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.49"
                     /tool="antismash"
     gene            complement(7550..8272)
                     /locus_tag="A4R25_RS06340"
     CDS             complement(7550..8272)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS06340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157538985.1"
                     /transl_table=11
                     /translation="MELRRSREKLWRGLTVFGVGVLPLLYHTSASTGRWILLGLWLVSA
                     GLFVAYQLRPFRFRIGADGLDLRVAGLNRLVAWAEIDAVVLDQPLPSRGRNQRAAKVLL
                     VPATAATIDRPLTSRSPVDGRPALKLLDLDQVRQPADDVADALARFGAGRFADVRQQAP
                     ELSDDADTPDTEALTLLADLTPRVQKALDSGQVSQRQAVKAEVDAALARLRAGGHQPRL
                     AALLKVMSDTLGEDVKPS"
     gene            complement(8407..9672)
                     /locus_tag="A4R25_RS06345"
     CDS             complement(8407..9672)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="A4R25_RS06345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_064445955.1"
                     /transl_table=11
                     /translation="MPPTGLRHNRDFLLITVARTASKLGTQVTAVATPLLVLLTTGSAT
                     DAGLVAFAEGIALVLVLLPAGLLADRRDRRILMLCCDAGALLAVTGVTVLALVGHAPVL
                     LIAVLAAATAGLGAALQPAAAAATRAVVPARDLRTATVFNETRNGVVHLAGPPLGGFLF
                     GLAPALPFLVDAISYAVSLVAVALLRGPLGRSATTPGESLPRQAVAGVRFLWRQPSLRF
                     TLLCGAVLNFAFAGVLLAIIVVPVRNGASGLSAGTVMACVGLGAVAGSLVASWLTARVP
                     TRWLILAVVWACAVLTAAMATTDNGLVLGALAGACVLVVPAANISMLTLQTLLTPGDLQ
                     GRANAATSFIALIVAPFGPALSGLLIDRVPAPVVFGSFAAVMLALAVGAAVAPAVRAMP
                     DLRAVEEAPEPGEAERRDPQPV"
     gene            complement(10001..12616)
                     /gene="lanKC"
                     /locus_tag="A4R25_RS06350"
     CDS             complement(10001..12616)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="A4R25_RS06350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_064445956.1"
                     /sec_met_domain="micKC (E-value: 2.4e-242, bitscore: 803.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 7.7e-14, bitscore: 48.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.2e-17, bitscore:
                     59.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPGAFLIADPVHVDSPAYVADTASRFPLADQTPPDGWRVAEHG
                     GWIMWHPPQAQLPQQGWKVHVSVNLDDAADVLDLVREHCVTHRVAFKFQRSRRLALVNN
                     EKYAHRAGSGKLAALYPADDTALRRVLDDLGARLAGYRGPYVLSDLRWHDGPLYLRYGG
                     FAELWCVDGDQPVPAVARPDGTLVPDRREPVFTVPDWAPVPDFVAEHIAAVAAVDAHTD
                     DEPPYRIEEALHHSNAGGVYRATDLRDGRTVVLREARPHAGLDGAGTDALTRLRREETM
                     LRRLAGLDCVPQLLDRLTWWEHQFLVEEHVDGDTLQHHLAMRHPLIHPDPTEQDLTDYT
                     TWALDVIDQVQAALARIHARGVVFGDLHTANIMIRPDGRIVLVDFEQAYLADEDFTPSL
                     GDPGFATPRIRRGTAVDTYALACLRLAVFVPLTPLAALSDDKFDDLLTIARRFPLPPGY
                     LDRIRDDLRTALHPPTPGRRRVTRHQWSADPRQLIESLAAGIRATATPHRTDRLFPGDP
                     GQFPHGGATLAHGAAGIIWALVTSGVDYPERDEHLDWLTRAARRLPAAHLGLYDGLAGI
                     AALLDRTGRHDDADELLDRCRTGLHHRYGPGLHSGLAGIGLALLRPGRPAPDDALHIGD
                     RLARTLTGDTTQPVPEPTRPGLLHGWSGPATFLTRLHETTGDPAWLRAARTALRRDLQH
                     TVRDDNGNLHVRDGARRLFYLDEGSAGIAVAAHTLLRHGERQWLRDIVTTVRRTIDVEF
                     VLLPGLFHGRAGLLATAALLTDDPPRRATPHGPIGLVRDDAPHHVPAHLARLAWHAYAL
                     DGHLAFPGDTLLRISTDLAAGGAGILSAMHAALHRTAVTLPFLDAPTHVAPNGHLLAAS
                     "
     gene            12902..13471
                     /locus_tag="A4R25_RS06355"
     CDS             12902..13471
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS06355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_064445957.1"
                     /transl_table=11
                     /translation="MRTEVQSPPVVVFLQAQRPAGWVTVARGVPLDGRRCLLRTVGAGR
                     ARSGDAVRLVGVAGGDARSLGVAEVSVLHRDEADLVMVSLAGATVPGGHGTDASSVRRV
                     LALLADDADGRWRVAADAAADVVAPVVLVGAGRAGAPGRTAVPVTTHRVGAATPSPDGD
                     GGGDDDGSPLSWTCRLFGIGCPTENS"
     gene            13479..14738
                     /locus_tag="A4R25_RS06360"
     CDS             13479..14738
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="A4R25_RS06360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_064445958.1"
                     /transl_table=11
                     /translation="MTSVTGAVAPSAPARAARWWRHDLLLLPVLGLLDLFTASSVVIQS
                     EPVGPARQWLQVLAAVLSVGALWWRARAPVAVFAFECVHGVAMWFLLHDYRPWVGLIVA
                     LYTVAALRPLVVSAAAYAAACARSLLSAFDSFRVEPSAGARAGEFVVTALMFALIYAAA
                     WAAGSVVRRHRRRVAQLERERRVARAEAVALERRRIAAELHDVVSHSVTVMVLQAAGAA
                     RISASDPERTREALLHIQQAGQQAMAELRRLLAVMRAESGPVGDGEPGPQPRLDDIEVL
                     LTSMRCAGLTVTMSVSGSPRPLDPSIELAAYRTVQESLTNTLKHVGRRACATVHFGWQE
                     RVLLLRVDDDGSGREPGAAAGLSTGNGLASLAERLERVGGRLVAGPRAEGGFRVSATLP
                     VAQHGDLVAASGDGGAPAVG"
     gene            14838..15545
                     /locus_tag="A4R25_RS06365"
     CDS             14838..15545
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018784313.1"
                     /locus_tag="A4R25_RS06365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_043324014.1"
                     /transl_table=11
                     /translation="MIRVLLADDQPLVRAGLAMLLTNEPDIEVVAEADDGAQAVEVSRR
                     LRPDVVLMDVRMPGTDGLAATRLMADEQLIDDPQQPVRIIMLTTYHVDEAVHAALRAGA
                     SGFVLKDAAPAELVSAIRAVADGEAWLDPAVARRLLDDLAARPDPGLPTPVQMRRLTPR
                     EREVLVLMAYGMSNREIAEHLVLGDATVKTHVSRVLTKLGLRDRTHAVVAAYQCGLVEP
                     GTAPPARMAGLSR"
     gene            complement(15586..17961)
                     /locus_tag="A4R25_RS06370"
     CDS             complement(15586..17961)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286351.1"
                     /locus_tag="A4R25_RS06370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_064445959.1"
                     /transl_table=11
                     /translation="MSEATTGLHRADSHDVIRVLGARENNLRDVHVELPKRRLTVFTGV
                     SGSGKSSLVFGTIAAESQRLINETYSAFVQGFMPTLSRPEVDVLEGLTTAIIVDQERMG
                     ADPRSTVGTATDVNAMLRILFSRLGDPHIGPPNAYSFNVPSVRAAGAITVERGPGKTQT
                     RKGTFNRLGGMCPRCEGRGAVTDFDLTVLYDEKLSLNEGAITIPGYSMDGWYGRIFRSS
                     GLFDPDKPIRDYTKRELSDLLHKEPTKIKVDGINVTYTGLIPAISKSMLAKDVDAMQPH
                     IRAFVERAITFTTCPDCDGTRLAPEARSSKINGVSIADVCAMQISDLATWVRDLREPSV
                     APLLKALGDTLDSFVEIGLGYLSLDRPAGTLSGGEAQRTKMIRHLGSSLTDVTYVFDEP
                     TIGLHPHDIARMNNLLLQLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGTAGGTICYE
                     GTVAGLRASGTTTGRHLDDRATLKDKPRTPTGALPIRGARTHNLRDVDVDIPLGVLVVV
                     TGVAGSGKSSLIHGSLARRDDVVSVDQTAIRGSRRSNPATYTGLLDPIRKAFAKANGVK
                     PALFSANSEGACPTCNGAGVIYTDLGMMAGVASTCEDCEGKRFQPAVLDYHLGGRDISQ
                     VLAMSVDEAEIFFSDGEARTPAAHTILDRLADVGLGYLTLGQPLTTLSGGERQRLKLAT
                     RMGDKGGVYVLDEPTTGLHLADVAQLLGLLDRLVDAGKSVIVIEHHQAVMAHADWIIDL
                     GPGAGHDGGRIVFEGTPADLVAARSTLTGEHLADYVGA"
     gene            complement(18018..18431)
                     /locus_tag="A4R25_RS06375"
     CDS             complement(18018..18431)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574739.1"
                     /locus_tag="A4R25_RS06375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_043330132.1"
                     /transl_table=11
                     /translation="MTITIHYTFLPHTDADAAIAFYRDTLGFELRNDVGQGDTMRWLTV
                     GPPNQPETGIVLHPPAVDPGISDDERRTILELIAKGSYGALTLATDDLDGLFDRLAASG
                     ADVVQEPTEQPYGVRDCAFRDPTGNLIRINERR"
     gene            complement(18437..18901)
                     /locus_tag="A4R25_RS06380"
     CDS             complement(18437..18901)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286348.1"
                     /locus_tag="A4R25_RS06380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_043324018.1"
                     /transl_table=11
                     /translation="MSPHQGTDDPAFAQRLRDLTRLRRVRDRIDREYASPLDVEALARG
                     EHMSAGHLSRQFRQTYGESPYSYLMTRRIERAMALLRRGDLSVTDVCFAVGCQSLGTFS
                     TRFTELVGEPPSAYRARHAPDTAEPPPCLTKQATRPIRNREARTGRPPLA"
     misc_feature    complement(18443..18445)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19000..19851)
                     /gene="pdxY"
                     /locus_tag="A4R25_RS06385"
     CDS             complement(19000..19851)
                     /EC_number="2.7.1.35"
                     /GO_function="GO:0008478 - pyridoxal kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009443 - pyridoxal 5'-phosphate salvage
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pdxY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019872348.1"
                     /locus_tag="A4R25_RS06385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxal kinase PdxY"
                     /protein_id="WP_043324020.1"
                     /transl_table=11
                     /translation="MKILSIQSSVAYGHVGNSAAVFPLQRLRHEVWPVLTVHFSNHTGY
                     GAWRGPLLAPTDVADVIAGIADRGVLGTADAVLSGYQGDPAVGAVILDAVAQVKAANPA
                     ALYCCDPVMGDVGRGMFVRPGIPEYLRDTVVPRADIVTPNQFELEFLAGRTTDTLDDLL
                     AAVDTVRATGPRHVLVTSVLHGDLPAGHLEVVAVSDEGAWAVTTPLLPIAPNGGGDVTA
                     ALYLAHLATTGSPQTALERTTNSIYAVLEATLDAGTRELQLVAAQDAIAEPPTRFTARR
                     LR"
     misc_feature    complement(19836..19850)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            20030..21439
                     /locus_tag="A4R25_RS06390"
     CDS             20030..21439
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286346.1"
                     /locus_tag="A4R25_RS06390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="OFA family MFS transporter"
                     /protein_id="WP_064445960.1"
                     /transl_table=11
                     /translation="MLSALDRRHTVAPPGYSRWLIPPAALAIHLCIGQVYATSVYKNSL
                     IAHFDTSQTAIGVIFSIAIVMLGLSAAVAGTWVEANGPRKAMFVSACFWAAGFLVGALG
                     IATGQLWLLYLGYGVLGGIGLGIGYISPVSTLIKWFPDRPGLATGLAIMGFGGGAMVAS
                     PLSRQLLSFYDAGYDPSDSGSTASGSALVWLFVTLGIGYFVIMMFGVFNVRVPAPHWRP
                     AGFDPSTVAEKPLVTTANVSAANALKTRSFWLLWVVLFCNVTAGIGILEQASPMIQDFF
                     RDNGTSAVSVAAAGGFVGVLSLFNMAGRFVWSSTSDVIGRKPIYVVYLGVGMVLYLLLA
                     LVGQTSTALFVLLASVILSFYGGGFATIPAYLRDLFGTFEVGAIHGRLLTAWSAAGVAG
                     PLIVNGFLDAQGEPGTLTAAAYRPALFTMVGVLAVGLVANLLVRPVPERYHEPASGRDG
                     TAQGPTERSGS"
     gene            21436..21561
                     /locus_tag="A4R25_RS32020"
     CDS             21436..21561
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R25_RS32020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255361250.1"
                     /transl_table=11
                     /translation="MNEHSGGGQRTRLVVSWLVVSVLLGYGVVQTVITAAKLFTQ"
     gene            complement(21613..22341)
                     /locus_tag="A4R25_RS06395"
     CDS             complement(21613..22341)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (3-161). E-value: 2.4e-15. Score:
                     48.8. Matches aSDomain:
                     nrpspksdomains_A4R25_RS06395_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018255858.1"
                     /locus_tag="A4R25_RS06395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_043324027.1"
                     /sec_met_domain="adh_short (E-value: 6.3e-38, bitscore:
                     127.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 9.2e-32, bitscore:
                     107.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVTIVTGGGRGIGAATARRLAAEGHDLVIGYRADHTAAESVAA
                     DVRAAGRRAVTVAADTTDPDQVRRIFDAADQLGPLTGLVNNAGVTSPIGPFTDLRVDDL
                     REVVDVNLIGYVLCAQQAARRLTRGGAIVNVSSVAATLGSPGEYVHYAAVKAATDTLTV
                     GLAKELAPHGIRVNAVAPGIIRTTIHARSGVPDRPDSAAGRIPMGRAGEPEEVAGAIAH
                     LLGPDASYTTGAVLRVGGGL"
     aSDomain        complement(21859..22332)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS06395_PKS_KR.1"
                     /evalue="2.40E-15"
                     /label="A4R25_RS06395_PKS_KR.1"
                     /locus_tag="A4R25_RS06395"
                     /protein_end="161"
                     /protein_start="3"
                     /score="48.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VTIVTGGGRGIGAATARRLAAEGHDLVIGYRADHTAAESVAADVR
                     AAGRRAVTVAADTTDPDQVRRIFDAADQLGPLTGLVNNAGVTSPIGPFTDLRVDDLREV
                     VDVNLIGYVLCAQQAARRLTRGGAIVNVSSVAATLGSPGEYVHYAAVKAATDTL"
     CDS_motif       complement(22264..22326)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R25_RS06395_0001"
                     /evalue="2.50E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="A4R25_RS06395"
                     /protein_end="26"
                     /protein_start="5"
                     /score="17.0"
                     /tool="antismash"
                     /translation="IVTGGGRGIGAATARRLAAEG"
     misc_feature    complement(22401..22415)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.06"
                     /tool="antismash"
     misc_feature    complement(22569..22580)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 cgcggcggct cagccggcgg cgaacgcgtc cagggcggcg accacccgct cgccgatgcc
       61 gtgcccgccg ccgtgcccgc cggactccac gatctccagc cgcgcatcag gccagtcccg
      121 ggttagcagc cacgcgatgt ccggcgggcc gctgacatcc agccggccct gcaccagcac
      181 ccccggaatg cccgccaggc ggcccgcgtc gcgcagcacc tgcccgtccg gctggaaacc
      241 ccggttcgcg aagtagtgcg tcaccagccg ggcgaacccg taccggaaca ccggatcggc
      301 gaaccgcgga tccggcgcgt acccgcccgc gagggacacg tgcacgtcct cccagtcgca
      361 ccagtcccgc gccgcccgct cccgcaccgc cgggtccggg tcgtcgagca gccgcgcgta
      421 cgccgccgac aggtcaccgt cccggtcggc ctccggcacc ccgtcacgga accgcgccca
      481 ctcctgcggg aacacccggc ccatgtcccg ggtcaaccac tcgatctccc ggctggtgtt
      541 ggcgaccacg ctgaacagca ccagcgcggt gacccgctgc gggtgccgct gcgcgtacgc
      601 cagcgccagc gacgaccccc acgacgcgcc gcacagcagc cacctgtcga tccccaggtg
      661 cgcgcgcagc gcctccatgt cggccagcag atgcgcggtg gtgttcaccg acaggtccgt
      721 ggccggatcc gacgccaggg gagtgctgcg cccacagcca cgctggtcga acaacacgat
      781 ccggtacgcg gctgggtcga acagccgccg ccaccccgcg cccgcgcccg aacccggacc
      841 gccgtgcacc acaagcgccg gccggccgtc cggattgccg cacgtctccc agtacacgcg
      901 ctgcccgtcc ccgacgtcca gcatcccctg ggcgtacggc tcgatcggcg gatacatgcg
      961 gcggcctccc agcgtcggtg tccgcacacc ctacgagcgt cgccgccccg gcgggtgccc
     1021 cccaccgcgc ggtaagcaac ggatagcctt ccggacatga ctatgcgccc gatccggatc
     1081 atcggcgacc ccgtgctgcg cacccccagc gaacccgtca ccagcttcga cgccgaactg
     1141 cgcgccctcg tcaccgacct gatggacacg ctgctcggcg cacccggacg cgccggcgtc
     1201 gccgcgcccc agatcggcgt caacgcccag gtgttcgtct acgacgccga cggccggcgc
     1261 ggccacatga tcaaccccac gttggaactg tccgacgaac tccaggacga cgacgagggc
     1321 tgcctgtcca tccccggcct gtacttcccg accccccgcg ccctgcacgc caccgcccac
     1381 ggctacgacc agcacggcga acccctcacc atcaccggca gcggcttcct cgcccgcgcc
     1441 ctgcaacacg agaccgacca cctgcgcgga cgcctctacg tcgacaccct gcgcggcgac
     1501 acccgccgcc gggccctgcg cgagatccgc gccggccggt tcgactcacc cagccgcggc
     1561 cgctgacgtc aacgcgcact cggtgaaccc ggccacccgg gagaacccca accgctcgta
     1621 cagccgcacc gccgccgcgt tgtccgcccg cacgttgagc gtcacatgat ccaccgacgt
     1681 gcgcagccgc gcgcacaacg ccgccaccac ccccgcgccc agaccccgac cccgcacgtc
     1741 cggatgcgtc gtcacgttcc ccagcgccgc cacccgccac cgcggcgaga acacgtgcac
     1801 gcccgccacc gccaccagcc ggccgtcctc ccgcacgccc acgtactggc ccgtgtccag
     1861 catccgcgga tcgaaccagt tccccggata cgccaccgcg tacaacccgg aaagctccgc
     1921 cgcgtccgcc ggccccaacg gctcacccac cgccggcgcc gccgccaacc gacctggatc
     1981 cgtcaacgcc atccggtgat gcgccgccgc ctccgacacc acgaaccagc ggcccaccac
     2041 cgcctccaga ccgggggaca ggtgcgccca catccgcgcc ggcaacaccg gcgccgcctc
     2101 cgccagcaac cccgccaact ccggcacccg atccggcgcc gcgaacgcca gcaacgtcgg
     2161 caactccacc ccgtgataca gcaacaccac ctggtcgcca cgccggaacc acgacgtgta
     2221 cggccagaag aaatcgtcca gatcacccaa ctggtacgcg tgcaacaccg gatcccggcc
     2281 cagcagaccc gccagcaccg cccgatcgtg ctccgcccgc accgccaccg cgatcagccc
     2341 gccaaccact ggtcgtaacc caaccgggcc accaacgcca gcaccaccac cagcagcacc
     2401 acccgcacga accccgcacc ccgccgcaac gccatccgcg cgcccaccgc cgcccccacc
     2461 acgttgcaca ccgccatcgc cgcacccaac gcccaccaca cgtgccccgt caacccgaac
     2521 accacaagcg cacccagatt cgtacccgcg ttcaccacct tcgccatcgc cgacgcgtgc
     2581 acgaaatccg aacccagaat cgccgtgaac gccaacacca gaaacgtgcc cgtacccggc
     2641 ccgatcaacc cgtcgtacag ggcgatgccc aacccggcca ccgccaccgc caccaccacc
     2701 cgccccggcg tgcgccgcgg cgacgacacc acacccagcg acggccgcgc catcacgaac
     2761 accgccaccg ccaccagcac cacaagcacc accggccggt acgcgccacc cggcaccgca
     2821 cccgcaagcg ccgcacccaa ccccgccgtc agcaccgcca accccgccgc cggacccgcc
     2881 acaccccagt ccagcttcgt ccgccgcgca tacgtcaccg ccgccgtcga cgtaccgaaa
     2941 atcgccgcca gcttgttcgt gcccaacgcc gtcgccaccg gcacacccgg cgccgccacc
     3001 agcaacgccg gcaacaacaa cagaccaccg ccacccacca ccgcgtccac ccaccccgcg
     3061 acaagggcag cggtcagcaa cgtcgtcaac gacagggcat ccaccgccgc attctgccca
     3121 ccccgccacc agcgacaacg ccacctgtgg caagcctcac cggccccgac gacgccgcaa
     3181 ccacaccccc accgacccca ccgccacgaa caccagcatc gaacagcaca acagtctcag
     3241 cacccggcaa gactgccacg acgacgtagg gtgtccaggt gcgcctggcc accttcaacc
     3301 tgctgcacgg ccgatccctc accgacggac tcgtcgaccc cgaccggctc accgccgccg
     3361 tcaccgccct cgacgccgac gtcctcgccc tccaggaagt cgaccgcgac cagacccgca
     3421 gcggcaaact cgacctcacc gccctggccg cccgcgccct gcacgccgac caccaccgct
     3481 tcgccgccgc cgtcgtcggc acccccggag aacagttccg ccccctcacc cacgacgacg
     3541 acggccacgg cgaacccctc tacggcatcg gcctgatcag ccgccacccc gtccgctcct
     3601 ggcaggtcac ccgcctacgc gccgcccccg tccgctcacc catctacgca cccggacccg
     3661 gcggcggcct catcctgctc cgcgacgaac cccgcgtcgt gctcgccgcc gtcctcgaca
     3721 ccccccacgg ccccctcacc gtcgccgcca cccacctgtc cttcgtcccc ggctggaaca
     3781 tctggcaact acgccgcgtc atccgcgccc tgcgcaccct gcccgcaccc cggatcctgc
     3841 tcggcgacct caacctgccc gccggacccg ccgccgcgct cacccgctgg cgacccctcg
     3901 cccgccgccc cacctacccg gccgggcaac cccgcgtcca actcgaccac atcctcgccg
     3961 accggcacgc cctcgaccgg ctcccacccg tcaccgccgt ccacacaccg ctggccacca
     4021 tctccgacca ccggcccctc gtcgtcgacc tcggctgacg ctcaacccag cccggcctgc
     4081 cgccgcgccg cgtcgaccgc gttacggaac aacatcgcca cagtcgtcgg acccaccccg
     4141 cccacacgcg gcgtgatcgc acccgccacc tcggcacacg actcgtccac gtccggcaac
     4201 aaccgccgcc cctcgtaccg caccccacca ccgaccacca ccgcacccgg acgcacatgc
     4261 tccggccgca cgatccccgg cacccccgcc gccgcgatca ggatctccgc ccgccgcgtg
     4321 taccgcggcc agtccgccac ccccgtgtgc accacagtca ccgcagcgtt cgccgtcggc
     4381 cgcttctgcg ccagcaacat cgcaagcggc cgacccaacg tcgcaccccg gcccaggatc
     4441 accacctccc ggcccgccac cggcacaccg tgaaacgcca gcaacgcctc gatccccgcc
     4501 ggcgtacacg gcaacggacc cggcaacccc aacgccagcc ggcccatgtt caccggatgc
     4561 atcccgtcca cgtccttgtc cggatccagc accgccaacg cccggtcgta gtccagatga
     4621 cccgggatcg gatactgcac cagcaccccg tggaccgtgg cgtccgcgtt gaaatccgcc
     4681 agcaccgcat gcagatccgc ctgcgacgcc gacgccggca gatgcacgtg cggcgacacg
     4741 aaacccaact ccgccgcctg gcgttgcttg atccggatat aacccgcgct cgcgtcgtcg
     4801 tcacccacca gcaccgtcgc cagcgccggc gtcacccccg ccgcacgcaa ctcggccacc
     4861 gacgcggcga cctccgacaa cacccgctcc gccaccggag cacccggcaa caaccgcgca
     4921 gaagacatac gacacctcgc ccgcaggggc ccaggcggtc gacccccacg acgagctccc
     4981 cgatggttca cccatccccg tgccgccagt cgcgttcccc ctcagcctgc cacagcctcc
     5041 gccgccaccg catccaccac cacctgccac cccggcaacg ccgccagcag accgtccgcc
     5101 cgccgccgcc gatccgccgc cgacgccaca cccagatccg ccagcaccgc ctggaacgcc
     5161 ggccgcaacg cccgctcccg ctccggcgcc accgcgccca acaccacatg acaccgcgcg
     5221 tacgtcacca gcacccagaa catcgcctcc cgatgccggc ccgccccgat cagctcaacc
     5281 gcaccgtcga acaccaccgg acgccccgcc gcacccagat ccgccccgaa cgcgaacccc
     5341 tcccgcggca accgcgccac ctcgtcgaac accaccgcca acccggccag atgcgcccgc
     5401 acccgcgcca cgtccacacc cgccccgccg ccgtcgagcg tgtccagcaa ccccggatac
     5461 cgaccggcga acccgaaccg cgacaacacg cgctccgccc gcacgtaccg ccgccgcacc
     5521 gtcggatcca ccagccccgc caccgccggc cacaccgcca gcaacgacgt cggaaacacc
     5581 cacgccaaca cctgctccgc ggttggcagc tcggcgtcga ccgcccacaa cccggcctcg
     5641 atccgccgcc gcacacccgc acaccgcgcc cgcacccaca ccggatccgc gaaccccgcc
     5701 gccacccgct cccgcaccgc gctcaaccgg cccgacggat ccgcgatcac cccatcggta
     5761 cgcaacatcg gcgcgaacac ccacgacccc agcacatcct ccgggccgcc caactccgcc
     5821 cacgtgatcg tgctgacctc cagcagcacc ccccgataca cgaacttgcc caccttcacg
     5881 ccgggctccc ggcgcaccag caacacgtcc acgtccgacc accgcggcaa caacgcgtcg
     5941 tccggcaacc ccacagtcga cccgctgaag aacgccccct cgatcgccgg atcgacgcgc
     6001 atccgctccc gtacccaccc ggccgccacc gcccgcgccg cacccacccg catccgcccg
     6061 atcctgccag cccggcagac cgccgcgcgg ccctcaccgc cgcggcgcca accccgacaa
     6121 cgcccgattg gtgcggttcg ccgccaccgc cgcccgctgc tgacccgccg tcacctcgat
     6181 gtacgtctgc gacgacgcca acgacgcatg ccccagcaac cgcatgatct ccgccgcgct
     6241 cgccccgtcc tccgccaacc gcgttgcgaa cgtgtgccgc agcgcgtgca accgcgcgcc
     6301 ccggggcacc cggtcaccga tgcccgcccg ccggtaacac gactccacca ggtactgcag
     6361 cccaccccgc cgcaacgcct caccctggcg gtccaccagg aacgcagagt ccggccgcac
     6421 actgcgcgcc ccgaaccgga gccgccggct gtccagataa cccgtgagca cccggtccac
     6481 ggcatcctcg atcggcaccg tacgcggccg cccgcccttg cccgccacgt ccacccgccg
     6541 ctcgccgtcg cgccccgcca ccgacgacac ccgcagcgcc agcagctccg acaggcgcag
     6601 ccccgcgcac aacgccagcg ccagcaccgc caggtcgcgc tccggccacg ggtcacgctg
     6661 ccggccctcc gcgcgcgcca ccgccgccag cagctcctcc ggggtgtcct caccccggag
     6721 cggcttgggt cgggggagcg gcgtacgggg ccgccccacc gccggcatcg gattgcccgg
     6781 tacgacgccc tcggccacca ggaacgtgaa gaagctgttc cacgtcgacc aggcacgatg
     6841 gaccgacgcg gccgcgcggg gagcggcgaa ccgcgcgaac gccgcgcgca tcaccctggg
     6901 ggagagggag ctgaccgcga cccggtccag ggggagggga gtggcgtcgc cgtcggcggc
     6961 gatcagctcg gccaccgcgg tcagatcccg ccggtacgcg gccagggtgt ggggggaggg
     7021 cttgcgggtg gcccgggcgg tcaggaactc ctcgatcaga gcgcctaccg tttcgtccgg
     7081 tttgtcatgc ataagggata ttatgcatga ttctcgcgtt cccgccaggt tcccgccagg
     7141 aggctttccc cggggggcga ggtcgatcgg tcgatgatca actccacttc gccgaagtgg
     7201 cggcaaccag gcgctccgat gctgccacct cggcgaagtg gcggcagtga cgcccgtcga
     7261 cactcggtcg gtgccaggga gagcgggcga aagagggccg gcgccctctc tgctccggcg
     7321 atcatgaggt tggcggcgac aaatgggaca gcattcgcgg tcaacctcat gatcgccgga
     7381 gcggtggatg ggttgagagt gcggcgtcgc cggggctgcg cctaggtgtg cggtgcgacg
     7441 gggcagccgg ccggacctcc aagtcccgga aggtcagccg cctcgcgagg acgtccgggg
     7501 aggcccgccg gagctctact tgacataatg tacattatcg aatcacggct caggagggct
     7561 ttacgtcttc gccgagggtg tccgacatga ccttcagaag cgcggccagc cgtggctggt
     7621 gacctccggc ccgcagtctc gcgagtgccg cgtccacctc tgccttgacc gcctgccgct
     7681 gcgacacctg ccccgagtcg agcgccttct ggactcgcgg tgtcaggtcg gccaacaacg
     7741 tcagggcctc cgtgtccggc gtatccgcgt cgtcggacag ttccggggcc tgctgccgga
     7801 cgtccgcgaa tcgccctgcc ccgaaccggg ccagggcgtc cgccacgtcg tccgccggct
     7861 gccgcacctg atcgaggtcg agcagcttca gggccggccg cccgtcgacc gggctccggc
     7921 tggtgagcgg acggtcgatc gtcgcggcgg tggccggcac cagcagcacc tttgcggctc
     7981 tctggttccg gccacgggac ggtagcggct ggtcgagcac gacagcgtcg atctcggccc
     8041 atgccacgag ccggttgagc ccggcgaccc gcaggtccag tccgtcggct ccgatgcgga
     8101 accggaacgg cctgagctgg taggcgacga acaggccggc cgacaccagc cagaggccga
     8161 gaaggatcca tcgtccggtc gacgcggaag tgtggtacag cagcgggagc acgccgactc
     8221 cgaagaccgt gaggcccctc cacagcttct ctcggctcct acgcagctcc atgccggcac
     8281 ctcgtccctt gtggcctgtc ctgggagggg ccctacatgg tggcacgggc gaggcgctct
     8341 cgtgatcatc cgaacgtccc cggaaagacc agcacctctc ccctgcctgc cggcacgaag
     8401 atcagctcag accggctgcg ggtcgcggcg ctcggcctcg ccgggctccg gggcttcctc
     8461 gacggcccgc aggtcgggca tggcgcgtac ggcgggcgcg acggccgcgc cgacggcgag
     8521 cgccagcatg acggccgcga agctgccgaa caccaccggc gccggtacgc ggtcgatcag
     8581 caggccggac agggccgggc cgaacggcgc cacgatcagc gcgatgaagc tggtcgcggc
     8641 gttcgctctc ccctgcaggt cgccgggggt gagcagggtc tggagggtca gcatgctgat
     8701 gttggcggcc ggtacgacca ggacgcaggc gccggccagc gcaccgagga ccagtccgtt
     8761 gtcggtggtg gccatcgcgg cggtcagcac ggcgcaggcc cagacgacgg cgaggatcag
     8821 ccagcgggtg ggtacccggg cggtcagcca ggacgcgacg agtgatccgg cgacggcgcc
     8881 gaggccgacg catgccatga cggttccggc ggacaggccg gaggcgccgt tgcggaccgg
     8941 cacgacgatg atcgccagca ggacgcccgc gaacgcgaag ttcaggacgg cgccgcagag
     9001 cagcgtgaac cgcagcgacg gttgccgcca caggaaccgg accccggcga cggcctgccg
     9061 gggcagggac tcccccggcg tggtcgccga ccggccgagt gggccgcgca gcagggccac
     9121 ggcgaccagg gagacggcgt acgagatcgc gtcgacgagg aacggcagtg ccggggcgag
     9181 gccgaacagg aagccgccga gcggcgggcc ggcgaggtgg acgacgccgt tgcgggtctc
     9241 gttgaacacg gtggccgtac gcaggtcccg ggctgggacg acggcgcggg tggcggctgc
     9301 ggcggcgggt tgcagcgcgg cgccgaggcc ggcggtggcg gcggcgagga cggcgatgag
     9361 caggactggc gcgtgtccga cgagggcgag gacggtgacg ccggtgacgg cgagcagcgc
     9421 gccggcgtcg cagcagagca tgaggatgcg ccggtcgcgg cggtcggcga gcaggccggc
     9481 gggcaggagt acgaggacca gggcgattcc ttcggcgaag gcgacgaggc cggcgtcggt
     9541 ggcggagccg gtggtcagca ggacgagcag cggcgtggcg acggcggtga cctgggtgcc
     9601 gagtttcgac gcggtgcggg cgacggtgat gaggaggaag tcgcggttgt gtcgtaggcc
     9661 ggtgggcggc atgggggctc cgtgtgcgtg gtggcgggcg ggatgccggc ttcaccgggc
     9721 cgggttgacg acggacccgg gcgggcggtg gccgcccgcc cgggtcgcca ggcggatcag
     9781 gtgtggctgg ggctggtggc ccgttcgcca ctaccgtctc agccgttgca gcaggcgatg
     9841 ctgatgctgc tggactgcgg cgggaccgcg tggcgggtgc cgttctgcgt ggccatggcc
     9901 tgcaggttga ggagcttcgt catgggggtt cacctccttc tcgggtgtgg tgggttggcc
     9961 gtcggtggtt ccgacggggt ctgtgggcgc cgggcggggt tcagctcgcg gcgaggaggt
    10021 ggccgttggg tgcgacgtgg gtgggcgcgt cgaggaaggg cagcgtcacg gcggtgcggt
    10081 gcagcgcggc gtgcatggcg gacaggattc cggcgccgcc ggcggcgagg tcggtggaga
    10141 tgcgcagcag ggtgtcgccg gggaacgcga ggtggccgtc gagggcgtag gcgtgccagg
    10201 cgaggcgggc caggtgcgcg gggacgtggt ggggcgcgtc gtcgcggacg agtccgatgg
    10261 ggccgtgcgg ggtggcgcgg cgcggtgggt cgtcggtgag cagggcggcg gtggcgagga
    10321 gtccggcgcg gccgtggaag aggccgggca gcaggacgaa ttcgacgtcg atggtgcggc
    10381 ggacggtggt gacgatgtcg cgcagccact ggcgttcgcc gtggcggagc agtgtgtggg
    10441 cggcgacggc gatgccggcg ctgccttcgt cgaggtagaa cagccgtcgt gcgccgtcgc
    10501 gtacgtggag gttgccgttg tcgtcgcgga cggtgtgttg caggtcgcgg cgcagggcgg
    10561 tgcgggcggc gcggagccag gcggggtcgc cggtggtttc gtgcaggcgg gtgaggaagg
    10621 tcgcggggcc ggaccagccg tggagcaggc cggggcgggt gggttcgggt acgggttgcg
    10681 tggtgtcgcc ggtgagggtg cgggcgagtc ggtcgccgat gtgcagggcg tcgtcggggg
    10741 cgggtctgcc ggggcgcagc agggcgagtc cgatgccggc gaggccgctg tgcaggccgg
    10801 ggccgtagcg gtggtgcagg ccggtgcgac atcggtcgag cagttcgtcg gcgtcgtcgt
    10861 ggcgtccggt gcggtcgagg agggcggcga tgccggcgag gccgtcgtag aggccgaggt
    10921 gggcggcggg caggcggcgg gcggcgcggg tgagccagtc gaggtgttcg tcgcgttcgg
    10981 ggtagtcgac gccgctggtg acgagtgccc agatgatgcc ggcggcgccg tgcgcgaggg
    11041 tggcgccgcc gtgcgggaac tggccggggt cgccggggaa gagccggtcg gtgcggtgtg
    11101 gtgtggcggt ggcgcggatg ccggcggcca gggattcgat cagctggcgc gggtcggcgg
    11161 accactggtg gcgggtgacg cggcggcggc cgggcgtggg tgggtgcagt gcggtgcgca
    11221 ggtcgtcgcg gatgcggtcg aggtatccgg gtggtagcgg gaagcgccgg gcgatcgtga
    11281 ggaggtcgtc gaacttgtcg tcgctcaggg cggcgagtgg tgtcagtggt acgaagacgg
    11341 cgaggcgcag gcaggcgagg gcgtaggtgt cgacggcggt gcctcggcgg atgcgggggg
    11401 tggcgaatcc ggggtcgccc agtgaggggg tgaagtcctc gtcggcgagg tacgcctgtt
    11461 cgaagtcgac gagcacgatc cggccgtcgg ggcggatcat gatgttggcg gtgtgcaggt
    11521 cgccgaagac cactcccctg gcgtgtatcc gggccagggc tgcctggacc tggtcgatga
    11581 cgtcgagtgc ccaggtggtg tagtcggtga ggtcctgctc ggtggggtcg gggtggatga
    11641 gtgggtgtcg catggcgagg tggtgttgga gggtgtcgcc gtcgacgtgc tcttcgacca
    11701 ggaactggtg ttcccaccag gtgaggcggt cgagtagttg ggggacgcag tcgaggccgg
    11761 cgaggcgccg cagcatggtc tcttcgcggc gcaggcgggt gagcgcgtcg gttccggcgc
    11821 cgtcgagtcc ggcgtgcggg cgggcttcgc gcaggacgac ggtgcggccg tcgcgtaggt
    11881 cggtggcgcg gtagacgccg ccggcgttgg agtggtgcag ggcttcctcg atgcggtagg
    11941 gcggttcgtc gtcggtgtgc gcgtcgacag cggcgacggc ggcgatgtgt tcggcgacga
    12001 agtcgggcac gggggcccag tcgggcacgg tgaagacggg ttcgcggcgg tcggggacga
    12061 gggttccgtc ggggcgtgcg acggcgggga cgggctggtc gccgtcgacg caccagagtt
    12121 cggcgaatcc gccgtagcgc aggtagaggg gtccgtcgtg ccagcgcagg tcgctgagga
    12181 cgtaggggcc gcggtagccg gcgaggcggg cgccgaggtc gtcgaggacg cggcgcaggg
    12241 cggtgtcgtc ggccgggtag agggcggcga gtttgccgct gccggcgcgg tgggcgtact
    12301 tctcgttgtt gaccagggcg aggcggcggc tgcgttggaa cttgaaggcg acccggtggg
    12361 tcacgcagtg ttcgcgtacc aggtcgagga cgtcggcggc gtcgtcgagg ttcaccgaga
    12421 cgtggacttt ccagccctgc tggggcagct gcgcctgcgg cgggtgccac atgatccagc
    12481 cgccgtgttc ggcgacgcgc cagccgtcgg gcggggtctg gtcggccagc gggaaccggc
    12541 tcgccgtgtc ggcgacgtac gccggtgagt cgacgtggac cgggtcggcg atcaggaacg
    12601 ctccgggcgt gggcatggca aacctcgcgg ccgtgacgat gggttgggtg tccgggacgg
    12661 gttcggtgtg ttgccgtcgt cgtccggact ggttccatcg tggtggtagc cggccggtcc
    12721 tggcgtccgg ccgtggggcg aggttcgggg tccgtcccgg cccggtggtg gacgtcgggg
    12781 gtccgtctgg aagtggacac cggatgtcac ccggtacggg gacgtccggc gggccggtgt
    12841 ggaccagaat ttctcgcgta cgcgggctgt tcgcccgcat ttccttctgt ggaggtctgt
    12901 gatgaggacc gaggtccagt cgccgccggt ggtggtgttc ctgcaggcgc agcggccggc
    12961 ggggtgggtg accgtcgcgc gtggggtgcc gttggacggg cggcggtgtc tgctgaggac
    13021 ggtgggtgcg ggccgggcgc gttccggcga cgcggtgcgt ctggtggggg tggccggcgg
    13081 ggacgcgcgg tcgctcggtg tcgccgaggt gtcggtgttg caccgtgacg aggcggacct
    13141 ggtgatggtg tcgctggccg gcgcgacggt tcccggtggc cacggcacgg acgcttcgtc
    13201 ggtgcggcgg gtgctggcgt tgctcgccga cgacgcggac gggcggtggc gggtggccgc
    13261 ggacgcggcg gccgacgtcg tggcgccggt cgtgctggtg ggggcgggcc gggcgggtgc
    13321 gccgggccgg acggcggtgc cggtgaccac gcaccgggtg ggcgcggcca cgccgtcgcc
    13381 ggacggtgac ggcggcggtg acgacgacgg ctcgccgctg tcctggacgt gccggttgtt
    13441 cggcatcggc tgccctacgg aaaactcctg atccgctgat gacgtcggtg accggtgcgg
    13501 tggcgccgtc cgccccggcg cgggcggcga gatggtggcg tcacgatctt ctgctgttgc
    13561 cggtgctggg cctgctcgac ctgttcacgg cgtcgtccgt ggtgatccag agcgagccgg
    13621 tcggcccggc ccggcagtgg ctgcaggtgc tcgccgcggt gttgtcggtc ggcgccctgt
    13681 ggtggcgggc ccgcgcgccg gtggcggtgt tcgcgttcga gtgcgtgcac ggcgtggcga
    13741 tgtggttcct gctgcacgac taccggccgt gggtgggcct gatcgtggcg ttgtacacgg
    13801 tggcggcgtt gcggccgctg gtggtgtcgg cggcggcgta cgcggcggcg tgcgcgcgga
    13861 gcctgctcag cgcgttcgac tcgttccggg tggagccgag tgcgggcgcg cgggccgggg
    13921 agttcgtggt gaccgcgttg atgttcgcgc tcatctacgc ggctgcgtgg gcggccgggt
    13981 cggtggtgcg gcggcaccgg cggcgggtgg cccagttgga gcgggagcgg cgggtggcgc
    14041 gggcggaggc ggtggcgttg gagcgtcgcc ggatcgccgc ggagctgcac gacgtggtgt
    14101 cccactcggt gacggtgatg gtgctgcagg ccgccggcgc ggcgcggatc agcgcgtccg
    14161 atccggagcg gacccgggag gcgctgctgc acatccagca ggccgggcag caggcgatgg
    14221 cggagttgcg gcggctgctg gcggtcatgc gggccgagtc ggggccggtg ggcgacggtg
    14281 agccgggtcc gcagccgcgg ctggacgaca tcgaggtgct gctgacgtcg atgcggtgcg
    14341 cggggctgac cgtgacgatg tcggtgtccg gcagccctcg gccgctggat ccgagcatcg
    14401 agctggcggc gtaccggacg gtgcaggaga gcctgacgaa cacgctcaag cacgtcggcc
    14461 ggcgggcctg cgcgactgtt catttcgggt ggcaggagcg ggtgctgttg ctgcgcgtcg
    14521 acgacgacgg ctcgggccgc gagccgggcg cggcggcggg gctgtcgacc ggtaacgggc
    14581 tggccagcct cgccgagcgg ctggagcgtg tcggcggtcg tctggtcgcc gggccgcgtg
    14641 ccgagggcgg gttccgggtg agcgcgacgc tgccggtcgc gcagcacggc gacctcgtgg
    14701 cggcctccgg tgacggcggg gcgccggctg tcgggtgaac ggcgtgtccg ctgtgcgaca
    14761 tcagggtggc cgccgccgcc ggcgtcgatg atcatgtggt ggggccactg tcccggccgc
    14821 cgacgacggg agccttcatg atccgggtgc tgctcgccga cgaccagccg ctcgtacggg
    14881 cgggactcgc gatgctgctc accaacgaac ctgacatcga ggtcgtcgcc gaggccgacg
    14941 acggggcgca ggccgtggag gtcagtcggc ggctgcgccc ggacgtggtg ctgatggacg
    15001 tgcggatgcc cggcaccgac gggttggccg cgaccaggct gatggccgac gagcagctca
    15061 tcgacgaccc gcagcagccg gtgcggatca tcatgctgac cacgtaccac gtggacgagg
    15121 cggtgcacgc cgcgttgcgg gcgggcgcgt ccggtttcgt gctcaaggac gccgcgcccg
    15181 ccgagctggt gtcggcgatc cgggcggtgg ccgacggcga ggcgtggctg gatccggcgg
    15241 tggcccggcg gctgctcgac gacctcgccg cccggcccga cccgggactg cccaccccgg
    15301 tgcagatgcg ccggctcacc ccgcgggaac gggaggtgct ggtgctgatg gcgtacggga
    15361 tgtcgaaccg ggagatcgcc gagcatctgg tgctgggcga cgcgactgtc aagacgcacg
    15421 tcagccgggt gctgacgaag ctggggctgc gggaccggac gcacgcggtg gtggccgcgt
    15481 accagtgcgg cctggtggag cccggcacgg cgccgccggc ccggatggcc ggtctgtccc
    15541 gctgaggtcc gcggcgcggc cgggggtctc agcggggaac ggcggtcagg cgccgacgta
    15601 gtcggcgagg tgttcgccgg tgagcgtgga ccgggcggcc accagatccg ccggggtgcc
    15661 ctcgaagacg atccggccgc cgtcgtgacc ggcgccgggg ccgaggtcga tgatccagtc
    15721 ggcgtgcgcc atgaccgcct ggtggtgttc gatcacgatg acggacttgc ccgcgtcgac
    15781 gagccggtcg agcaggccga gcagctgggc gacgtcggcc aggtgcaggc cggtggtggg
    15841 ttcgtccagg acgtacacgc cgcccttgtc ccccatccgg gtggcgagct tgaggcgctg
    15901 gcgttccccg ccggacagcg tggtcagcgg ctggccgagc gtgaggtagc cgaggccgac
    15961 gtcggcgagc cggtcgagga tggtgtgggc ggccggggtg cgggcctcac cgtcgctgaa
    16021 gaagatctcg gcctcgtcga cggacatcgc gaggacctgg ctgatgtcgc ggccgccgag
    16081 gtggtagtcg agcacggcgg gctggaaccg tttgccttcg cagtcctcgc aggtgctggc
    16141 gacgccggcc atcatgccga ggtcggtgta gatgacgccg gcgccgttgc aggtcgggca
    16201 ggcgccttcg gagttggcgc tgaacagggc gggtttgacg ccgttggcct tggcgaacgc
    16261 cttgcggatc gggtcgagca gaccggtgta ggtggccggg ttgctgcggc gggagccacg
    16321 gatggcggtc tggtcgacgc tgacgacgtc gtcgcgtctg gccagtgagc cgtggatgag
    16381 gctgctcttg ccggagccgg cgacgccggt gaccacgacc aggacaccga gggggatgtc
    16441 cacgtcgacg tcgcgcaggt tgtgggtgcg ggcgccgcgg atcggcagcg cgccggtggg
    16501 cgtacgcggc ttgtccttga gggttgcgcg gtcgtcgagg tggcggccgg tggtggtgcc
    16561 gctggcgcgc aggccggcga cggtgccctc gtagcagatg gtgccgccgg cggtgccggc
    16621 gccggggccg aggtcgacga cgtggtcggc gatggcgatg gtttcgggtt tgtgttcgac
    16681 gacgaggacg gtgttgccct tgtcgcgcag ttgcagcagg aggttgttca tgcgggcgat
    16741 gtcgtgcggg tgcagcccga tggtgggttc gtcgaagacg taggtgacgt cggtgaggga
    16801 cgagccgagg tggcggatca tcttggtgcg ctgggcctcg ccgccggaga gggtgccggc
    16861 gggccggtcg aggctgaggt agcccaggcc gatctcgacg aacgagtcga gggtgtcccc
    16921 cagcgccttg agcagcgggg cgacggaggg ttcgcgcagg tcgcgtaccc aggtggcgag
    16981 gtcgctgatc tgcatggcgc agacgtcggc gatgctgacg ccgttgatct tcgaggagcg
    17041 ggcttcgggg gccaggcggg tgccgtcgca gtcggggcag gtggtgaacg tgatggcgcg
    17101 ttcgacgaag gcgcggatgt gcggctgcat ggcgtcgacg tccttggcga gcatcgactt
    17161 gctgatggcg gggatgaggc cggtgtaggt gacgttgatg ccgtcgacct tgatcttggt
    17221 gggttccttg tggagcaggt cgctcagttc ccgcttggtg tagtcgcgga tcggcttgtc
    17281 cgggtcgaac aggccgctgg agcggaagat gcggccgtac cagccgtcca tgctgtagcc
    17341 gggaatggtg atggcgccct cgttgaggga cagcttctcg tcgtagagga cggtcaggtc
    17401 gaagtcggtg accgcgccgc ggccctcgca gcgggggcac atgccgccga ggcggttgaa
    17461 ggtgcccttc ctggtctggg tcttgccggg gccccgctcg acggtgatcg cgccggcggc
    17521 gcgtacggaa gggacgttga acgagtaggc gttgggcggg ccgatgtggg ggtcgccgag
    17581 gcggctgaac aggatgcgca gcatcgcgtt gacgtcggtg gcggtgccga cggtggagcg
    17641 tgggtccgcg cccatgcgtt cctggtcgac gatgatggcg gtggtgaggc cctccaggac
    17701 gtcgacctcg ggccgggaca gggtgggcat gaacccctgg acgaaggcgc tgtaggtctc
    17761 gttgatcagg cgctgggact cggcggcgat ggtgccgaag accagtgagc tcttgccgga
    17821 gccggacacg ccggtgaaca ccgtgaggcg gcgtttgggc agctcgacgt ggacgtcgcg
    17881 caggttgttc tcgcgggcgc cgaggacgcg gatgacgtcg tggctgtcgg cgcggtgcag
    17941 gccggtggtg gcctcgctca tgatttctcc gtccgggtcg ggtgttccgg tcgagccagc
    18001 gtccgccgcg ggcgccgtca gcgccgctcg ttgatgcgga tgaggttgcc ggtggggtcg
    18061 cggaacgcgc agtcgcgtac gccgtagggc tgttcggtgg gttcctggac cacgtcggcg
    18121 ccgctggccg ccagccggtc gaacaggccg tcgaggtcgt cggtggcgag ggtgagcgca
    18181 ccgtagctgc ccttggcgat gagttcgagg atggtgcggc gctcgtcgtc gctgatgccg
    18241 gggtcgacgg ccggcgggtg caggacgatg ccggtctcgg gctggttcgg tgggccgacg
    18301 gtgagccagc gcatggtgtc gccctggccg acgtcgttgc gcagttcgaa gccgagggtg
    18361 tcgcggtaga aggcgatggc ggcgtcggcg tcggtgtgcg gcaggaacgt gtagtgaatg
    18421 gtgatcgtca tggtggtcac gctaacggtg gccggccggt gcgggcttct cgattcctga
    18481 tcggtcgggt cgcctgtttg gtcaggcacg ggggcggctc ggcggtgtcg ggggcgtgac
    18541 gggcgcggta ggcgctgggc ggttcgccga cgagttcggt gaaccgggtg ctgaaggtgc
    18601 ccagggactg acagccgacg gcgaagcaga catcggtgac gctgaggtca ccacggcgca
    18661 gcagggccat cgcgcgttcg atgcggcggg tcatgaggta cgagtacggg gactcgccgt
    18721 aggtctggcg gaactggcgg ctgaggtggc cggcggacat gtgctcgccg cgggcgaggg
    18781 cttcgacgtc gaggggactg gcgtactcgc ggtcgatgcg gtcgcggacg cggcgcagcc
    18841 gggtcaggtc gcgcagccgt tgggcgaacg cggggtcgtc ggtgccctgg tgcggtgaca
    18901 cgtccgcatc ctgcctgctg ggcggtggtg tcgtccacct gttcgagcgg cgagtcgccg
    18961 cccgggtgca cctgggcggc tggtgcaccc gggcggcggt cagcgcagcc ggcgggcggt
    19021 gaaccgggtg ggcggctcgg cgatggcgtc ctgggcggcg acgagttgca gctcccgggt
    19081 gccggcgtcg agggtcgcct cgagtaccgc gtagatcgag tttgtggtgc gttccagcgc
    19141 ggtctgtggt gagccggtgg tggcgaggtg cgccaggtag agggcggcag tgacgtcgcc
    19201 gccgccgttg ggggcgatcg gcagcagcgg ggtggtgacg gcccaggcgc cctcgtcgga
    19261 cacggcgacg acttccaggt gcccggcggg caggtcgccg tgcaggacgc tggtgaccag
    19321 gacgtgccgg gggccggtgg cgcggacggt gtcgacggcg gcgagcaggt cgtcgagggt
    19381 gtcggtggtg cggccggcga ggaactccag ctcgaactgg ttgggggtga cgatgtcggc
    19441 gcgggggacg acggtgtcgc ggaggtactc ggggatgccg gggcggacga acatgccgcg
    19501 gccgacgtcg cccatgaccg ggtcgcagca gtagagggcg gccgggttcg cggctttgac
    19561 ctgggcgacg gcgtcgagga tgaccgcgcc gacggcgggg tcgccctggt agccggagag
    19621 cacggcgtcg gcggtgccga gcaccccgcg gtcggcgatg ccggcgatga cgtcggcgac
    19681 gtcggtgggg gcgagcaggg ggccgcgcca ggcgccgtag ccggtgtggt tggagaagtg
    19741 cacggtcagg accggccaga cctcgtgtcg gaggcgttgc agcgggaaca cggcggcgga
    19801 gttgccgacg tggccgtagg cgaccgacga ctggatggac aggatcttca cctgctcatg
    19861 gtcgcatccc cggcgagggc tgacggcccg tggtggggtg atgacgggcc gggaccgcgg
    19921 tgaccgttcg gctcagggtt tcgaccgccg ggcgcggggc gggtttgggc gcagcgtgcg
    19981 gtgggggcat gaacgggctg ttctcgcctt ctggacggag gaagcaacga tgctttccgc
    20041 actcgatcgt cggcacaccg tcgcgccgcc ggggtacagc cgctggctga ttcctccggc
    20101 ggcgctggcg atccatctgt gcatcgggca ggtgtacgcg acgagcgtgt acaagaactc
    20161 cctgatcgcg catttcgaca caagtcagac ggcgatcggg gtgatcttca gcatcgcgat
    20221 cgtgatgctg gggttgtcgg ccgcggtcgc cggtacgtgg gtggaggcga acgggccgcg
    20281 taaggccatg ttcgtgtcgg cgtgtttctg ggcggcggga ttcctggtcg gggcgctggg
    20341 catcgcgacc gggcagctgt ggctgctgta cctggggtac ggggtgctgg gcgggatcgg
    20401 tctggggatc gggtacatct cccccgtctc cacgttgatc aagtggttcc cggaccggcc
    20461 ggggctggcg accgggctgg cgatcatggg gttcggtggc ggggcgatgg tggcatctcc
    20521 cctgtcccgg cagctgctgt cgttctacga cgccgggtac gacccgtcgg acagcggttc
    20581 caccgcgtcg ggctcggcgc tggtgtggct gttcgtgacg ctcggcatcg gctacttcgt
    20641 gatcatgatg ttcggggtgt tcaacgtgcg ggtgccggcg ccgcactggc ggccagccgg
    20701 tttcgacccg tcgacggtgg cggagaagcc gctggtgacc acggcgaacg tgtcggcggc
    20761 caacgcgctg aagacgcggt cgttctggct gctgtgggtg gtgctgttct gcaacgtgac
    20821 ggcgggtatc ggcatcctgg agcaggctag cccgatgatc caggacttct tccgcgacaa
    20881 cgggacctcg gccgtgtcgg tggcggcggc cggcgggttc gtgggagtgc tgtcgctgtt
    20941 caacatggcg ggccggttcg tgtggtcgtc cacgtcggat gtgatcggcc gtaagccgat
    21001 ctacgtggtg tacctgggtg tgggcatggt gctgtacctg ctgctggcgc tggtggggca
    21061 gacctcgacg gcgttgttcg tgctgctggc atccgtgatc ctgtcgttct acggcggcgg
    21121 gttcgcgacc attccggcgt acctgcggga cctgttcggc acgttcgagg tgggcgcgat
    21181 ccacggccgg ctgctgaccg cgtggtcggc ggccggggtg gccgggccgc tgatcgtcaa
    21241 cggattcctc gacgcgcagg gcgagccggg cacgttgacc gcggcggcgt accggccggc
    21301 gctgttcacg atggtcggcg tgctggccgt cggcctggtg gcgaacctgc tggtgcggcc
    21361 ggtgccggag cgctaccacg agccggcgtc gggacgggac gggacagcgc aggggccgac
    21421 ggagaggagc ggatcgtgaa cgagcacagc ggtggcgggc agcggacccg cctggtggtg
    21481 tcgtggctgg tggtgtcggt gctgctgggc tacggggtgg tgcagacggt gatcacggcg
    21541 gcgaagctgt tcacccagta gcgcagaagg cgaggcggcg gcccggggcg aacaccccgg
    21601 gccgccgtcg tgtcagagcc cgccgccgac gcgcaggacc gcgcccgtgg tgtacgaggc
    21661 gtccgggccg agcaggtggg cgatcgcgcc ggcgacctcc tcgggttccc cggcgcggcc
    21721 catcgggatc cgcccggcgg cggagtcggg gcggtcgggc acgccggagc gggcgtggat
    21781 ggtggtgcgg atgatgccgg gggcgacggc gttgacgcgg atgccgtgcg gcgcgagttc
    21841 cttggcgagc ccgacggtga gggtgtcggt ggcggccttg acggcggcgt agtggacgta
    21901 ctcgccgggt gagccgagcg tggcggcgac ggaggagacg ttgacgatgg cgccgccacg
    21961 ggtgagccgc cgggccgcct gctgggcgca gagcacgtac ccgatgaggt tgacgtcgac
    22021 gacctcgcgc aggtcgtcga cgcgcaggtc ggtgaacggg ccgatcgggc tggtgacgcc
    22081 ggcgttgttg accaggccgg tgagcgggcc gagctggtcg gcggcgtcga agatgcggcg
    22141 tacctggtcc gggtcggtgg tgtcggcggc gacggtgacc gcgcggcggc cggccgcgcg
    22201 cacgtcggcg gccacggatt cggcggcggt gtggtcggcg cggtagccga tgaccaggtc
    22261 gtggccctcg gcggcgagcc gccgggcggt ggccgcgccg atgccgcgtc ctcccccggt
    22321 gacgatggtg acggaggtca atgcaattct cccctgcctt gcggtggggg cgacgttacc
    22381 gtgggcggga ccatccgggg tggagaggac tgtcacatgg ggcgcgcgtt ggtgctgggt
    22441 ggcggcgggg tcaccggggt ggcctgggag ctgggtctgc tggccgggct ggccgggcac
    22501 ggcctgcggt tggacgaggc ggagctggtg gtgggcacgt cggccgggtc ggtggtcggg
    22561 gcgcaggtgc gttcgggtac gccggtgacg cagttgtacg aggcgcagct gcggcc
//
