LOCUS       NZ_BBVA01000002        20951 bp    DNA     linear   CON 10-SEP-2024
DEFINITION  Micromonospora sp. NBRC 110037, whole genome shotgun sequence.
ACCESSION   NZ_BBVA01000002
VERSION     NZ_BBVA01000002.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Micromonospora sp. NBRC 110037
  ORGANISM  Micromonospora sp. NBRC 110037
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Igarashi,Y., Komaki,H., Ichikawa,N., Hosoyama,A. and Fujita,N.
  TITLE     Whole genome shotgun sequence of Micromonospora sp. NBRC 110037
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2438518)
  AUTHORS   Hosoyama,A., Ichikawa,N., Kimura,A., Ohshita,R. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAR-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 106x
            Sequencing Technology :: 454 GS-FLX Titanium; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001652995.1-RS_2024_09_10
            Annotation Date                   :: 09/10/2024 02:06:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,195
            CDSs (total)                      :: 6,136
            Genes (coding)                    :: 6,073
            CDSs (with protein)               :: 6,073
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 15 of 63
            Pseudo Genes (incomplete)         :: 53 of 63
            Pseudo Genes (internal stop)      :: 4 of 63
            Pseudo Genes (multiple problems)  :: 9 of 63
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 142818
            Orig. end                         :: 163769
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBVA01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20951
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20951
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20951
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10951](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10951)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(94..108)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(472..487)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.05"
                     /tool="antismash"
     gene            623..1045
                     /locus_tag="A4R25_RS00675"
     CDS             623..1045
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287577.1"
                     /locus_tag="A4R25_RS00675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RidA family protein"
                     /protein_id="WP_043329499.1"
                     /transl_table=11
                     /translation="MTAAPPEPPADAGVVTRLGSGGPWEALYGYSRVVRAGSLAITAGC
                     TSTVDGRVAHAGDAAAQTAQAIRIGLDALAEVGAGPGDVVRTRMYVTDRIFADEVGRAH
                     NAVFGPVRPVATMVVVAGLIDPDLLVEVELEAYLPA"
     misc_feature    complement(1096..1112)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 25.32"
                     /tool="antismash"
     misc_feature    1099..1116
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.03"
                     /tool="antismash"
     gene            1126..1572
                     /locus_tag="A4R25_RS00680"
     CDS             1126..1572
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018789360.1"
                     /locus_tag="A4R25_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_064446417.1"
                     /transl_table=11
                     /translation="MTDDLVLRRQVCFALYAASRAMTDVYRPILDERGLTYPQYLVLLV
                     LWERDDDAPTVSELGAALRLDSGTLSPLLKRLEAAGLVVRTRSAADERRVEVGLTGQGR
                     ALRERMCDVPRQVATATGLTEAELVFLHGILTRVTETIHRQKEQ"
     gene            1574..1999
                     /locus_tag="A4R25_RS00685"
     CDS             1574..1999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785232.1"
                     /locus_tag="A4R25_RS00685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="organic hydroperoxide resistance protein"
                     /protein_id="WP_064445243.1"
                     /transl_table=11
                     /translation="MQVLYTASARATGDGRDGHVRTSDGTVELDLAVPKEMGGAGGAAN
                     PEQLFAAGYAACFHSALRVVARKAKADVSGSVVEAEVGIGPNGSGGFGLAVTLVVDLPA
                     VERAAAEQLVDAAHQVCPYSNATRGNVEVTRTVREAR"
     gene            1996..2997
                     /locus_tag="A4R25_RS00690"
     CDS             1996..2997
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016628 - oxidoreductase activity, acting
                     on the CH-CH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (22-331). E-value: 4.3e-21.
                     Score: 67.3. Matches aSDomain:
                     nrpspksdomains_A4R25_RS00690_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014399.1"
                     /locus_tag="A4R25_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_064445244.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-22, bitscore:
                     76.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGMNREIHLASRPQGWPTAENFRLVTTEVPTPGPGQVVVRNRFM
                     SVDPYMRGRMNDVKSYVPPFALDAPLDGGAIGEVVAGEAGGVKPGDTVLHGLGWREYAL
                     VDAKGARKIDPDLAPVTAHLGVLGMTGLTAYAGLLDVAAMKPGETVFVSGAAGAVGSMV
                     GQIAKLRGAGRVIGSAGSAAKVERLTALGFDAAFDYHDGPVSKQLRAAAPDGVDVYFDN
                     VGGDHLEAAIGAMNVHGRAAICGMIAQYNATEPPAAPRNLALVIGKRLTLRGFLVSDHG
                     HLREQFVQEVAGWLREGRLSYDETIVDGIEQAPEAFLGLLRGENLGKMLVRL"
     aSDomain        2062..2988
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS00690_PKS_ER.1"
                     /evalue="4.30E-21"
                     /label="A4R25_RS00690_PKS_ER.1"
                     /locus_tag="A4R25_RS00690"
                     /protein_end="331"
                     /protein_start="22"
                     /score="67.3"
                     /tool="antismash"
                     /translation="FRLVTTEVPTPGPGQVVVRNRFMSVDPYMRGRMNDVKSYVPPFAL
                     DAPLDGGAIGEVVAGEAGGVKPGDTVLHGLGWREYALVDAKGARKIDPDLAPVTAHLGV
                     LGMTGLTAYAGLLDVAAMKPGETVFVSGAAGAVGSMVGQIAKLRGAGRVIGSAGSAAKV
                     ERLTALGFDAAFDYHDGPVSKQLRAAAPDGVDVYFDNVGGDHLEAAIGAMNVHGRAAIC
                     GMIAQYNATEPPAAPRNLALVIGKRLTLRGFLVSDHGHLREQFVQEVAGWLREGRLSYD
                     ETIVDGIEQAPEAFLGLLRGENLGKMLV"
     CDS_motif       2434..2478
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R25_RS00690_0001"
                     /evalue="9.00E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="A4R25_RS00690"
                     /protein_end="161"
                     /protein_start="146"
                     /score="8.9"
                     /tool="antismash"
                     /translation="GETVFVSGAAGAVGS"
     gene            3084..3851
                     /gene="hisF"
                     /locus_tag="A4R25_RS00695"
     CDS             3084..3851
                     /EC_number="4.3.2.10"
                     /GO_function="GO:0000107 - imidazoleglycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019900882.1"
                     /locus_tag="A4R25_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="imidazole glycerol phosphate synthase subunit
                     HisF"
                     /protein_id="WP_043329502.1"
                     /transl_table=11
                     /translation="MTVAVRVIPCLDVDAGRVVKGVNFLDLRDAGDPVELAAAYDRAGA
                     DELTFLDVTASSSDRGTMLDVVRRTAESVFIPLTVGGGVRQVADVDTLLRAGADKVGVN
                     TAAIARPELIAEIADRFGSQVLVLSLDVRRAPDGTTPSGFEVTTHGGRRGTGLDAVEWA
                     ARGAELGAGEILLNSMDADGTKAGFDLPLIQAVREVVDVPVIASGGAGEVAHFPPAVGA
                     GADAVLAASVFHFGELTVGEVKDALRGAGHPVR"
     gene            complement(3859..4320)
                     /locus_tag="A4R25_RS00700"
     CDS             complement(3859..4320)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018804515.1"
                     /locus_tag="A4R25_RS00700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_043329504.1"
                     /transl_table=11
                     /translation="MGENGWRWSDAWIFVALVIASGAGRHRRSASTRRPEGVRLADVLS
                     TADHLNQAIPERHEVEGAVRRLVGAGLVSVADGWFRVTPDGERLWRTRPSAGLGTTVDT
                     VQGVLTRRHPPGESEWQLDEDDHAAAVQEYVVRSIPMPRRSPEGHSGRQ"
     gene            complement(4437..5072)
                     /locus_tag="A4R25_RS00705"
     CDS             complement(4437..5072)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785228.1"
                     /locus_tag="A4R25_RS00705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YitT family protein"
                     /protein_id="WP_043329506.1"
                     /transl_table=11
                     /translation="MAPLGNLGHRSARRLTQLYAGLVLYGLSMALMIRSELGLDPWDVF
                     HQGLARQTGLSFGTVTIAVGALVLLLWIPLRQRPGLGTVSNVVVIGLVVDATLAVLPPG
                     EGMPARAAMLVAGIVANGAATGLYLGAGLGPGPRDGLMTGFVARHPRFSVRLVRTSIEV
                     TVLALGWLLGGTVGLGTVAYALTIGPLAQFFIPVFALPARPASGAYAT"
     gene            5132..6583
                     /locus_tag="A4R25_RS00710"
     CDS             5132..6583
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (111-461). E-value:
                     1.6e-30. Score: 98.3. Matches aSDomain:
                     nrpspksdomains_A4R25_RS00710_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014395.1"
                     /locus_tag="A4R25_RS00710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_064445245.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.4e-29, bitscore:
                     98.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQVRGVQLARLLGQWHALPGRRRSPDYAALAGAVRGLLADGRL
                     PLGVRLPAERELAEALRISRTTVTAAYRELRESGHLASRRGAGSWTMLPGGHRVASTGL
                     WTPLDDRDMIDLGVAALSAPPQLVPAARAAAEDLPRYLGGAGYHPTGIIELREAVARGY
                     TERGLPTSPEQIMVTSGTQHALDLVLRLALSPGGAVLVESPTYPNALAALAARRARIAT
                     HGLSDEGWDAELLLGSIRQTRPKLAYVIPEFHNPTGHLMAADLRERLVGAAHAAGTDLV
                     VDESFVDLPLDGTPLPPPVAVFDRHSRVISIGGMSKPYWGGLRIGWVRASAPQVQRLAA
                     ARVGVDMASPVLDQLVAVHLLAEAPAIVAARRAQLAAQRDALVAALAEQLPDWRVTPPR
                     GGVTLWAELDGPISSALARAAEEVGVRLAPGPRFGLDGTLERFLRLPFTLPAEELVEAV
                     GRLAAVRYDLDRTSRPQWREPSVIA"
     aSDomain        5465..6514
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS00710_Aminotran_1_2.1"
                     /evalue="1.60E-30"
                     /label="A4R25_RS00710_Aminotran_1_2.1"
                     /locus_tag="A4R25_RS00710"
                     /protein_end="461"
                     /protein_start="111"
                     /score="98.3"
                     /tool="antismash"
                     /translation="DMIDLGVAALSAPPQLVPAARAAAEDLPRYLGGAGYHPTGIIELR
                     EAVARGYTERGLPTSPEQIMVTSGTQHALDLVLRLALSPGGAVLVESPTYPNALAALAA
                     RRARIATHGLSDEGWDAELLLGSIRQTRPKLAYVIPEFHNPTGHLMAADLRERLVGAAH
                     AAGTDLVVDESFVDLPLDGTPLPPPVAVFDRHSRVISIGGMSKPYWGGLRIGWVRASAP
                     QVQRLAAARVGVDMASPVLDQLVAVHLLAEAPAIVAARRAQLAAQRDALVAALAEQLPD
                     WRVTPPRGGVTLWAELDGPISSALARAAEEVGVRLAPGPRFGLDGTLERFLRLPFTLPA
                     EELVEAVGRL"
     gene            6656..7963
                     /locus_tag="A4R25_RS00715"
     CDS             6656..7963
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072131.1"
                     /locus_tag="A4R25_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="low temperature requirement protein A"
                     /protein_id="WP_197494835.1"
                     /transl_table=11
                     /translation="MGDGDAVRWSWAVQRSAPGSRTTRLELFYDLVFVFAFLSVTTLTA
                     SVLTPANLYRFLLVLALLWWSWTGFARMGNAFRADQGMLPLIGVVTVAATFLLVLSTPS
                     AFANSGGWLPGPLVFAACYFVIRTAQLTVFAWADRADPARRRGLRMRFLAPTVATALLV
                     VAGTLPGRLPQERFAVGLQLALWTLALLVEYVAGTVLGQQWWVVLSAGHWAERHALIVL
                     VALGESIIALGLGPKRGLPLTGPVAIAALLGITVVAALWWAYFDTLAFAMEQVLHQARD
                     RATRLRLARTAYTFLHLPIVAGIILYALGLKDLLAEAADPHTPAWGLPLGDFWGAILFG
                     GVALHLLGVAGCWWVALREIHWRLLTTVGALTAVAPFVFRVPELVALIVLAVVTGAGVA
                     WETRGENGHRRRVRQLALEEQIAAEAEQSRWRQQHL"
     gene            complement(8035..9861)
                     /locus_tag="A4R25_RS00720"
     CDS             complement(8035..9861)
                     /NRPS_PKS="Domain: AMP-binding (14-471). E-value: 4.3e-88.
                     Score: 287.6. Matches aSDomain:
                     nrpspksdomains_A4R25_RS00720_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475807.1"
                     /locus_tag="A4R25_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_043329509.1"
                     /sec_met_domain="AMP-binding (E-value: 3e-86, bitscore:
                     286.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALDVPYRSVPDMFLKRVADSPDRQAFAHPAPDDSGPVWLTWEQV
                     GQRAKAIAAGLHGLGVGLENPVAILANTRLEWVLADFGIMCAGGATTTVYPTTEPDDAV
                     YIIADSGSKVLFAENPAQAAKIAGADLPALTHVVLFDGAPDPAAAVPQLTLAELEERGA
                     AALSAEPDLIDMLVAGIGPDHLATLIYTSGTTGRPKGVELLHGGWCWEGVAQAELGLLR
                     TDDLQYLWLPLSHSFGKTLLCGATHVGLPTYVDGRVDKLVDLLGVIRPTLMCGAPRVFE
                     KVYNKAVTTAQGAGGAKAKIFAWGVEVGKEKVALEQAGKPVPAGLRMKYALAEKLVFSK
                     LQARLGGRMRVLVSGAAPLSKEIATFFAAANLPISEGYGLTETSAGAFVNPPDGLKIGS
                     VGRAMGDLECRIDTDGEILMRGKPVMRGYHNLPEETAAAFTEDGFFRSGDIGTLDDDGY
                     LRITDRKKDLVKTSGGKYVAPSHIEGMFKAVCPYTSQAVVIGQARNYCTMLVTLDPDAI
                     KGWAAGTPLEGSDYTTIVTSPQAREMVEGYVAELNAKLNRWETIKKVTILPRDLTIEDG
                     EVTPSLKIKRRSVETNFSSEIDKMYEGTLAEL"
     aSDomain        complement(8449..9819)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R25_RS00720_AMP-binding.1"
                     /evalue="4.30E-88"
                     /label="A4R25_RS00720_AMP-binding.1"
                     /locus_tag="A4R25_RS00720"
                     /protein_end="471"
                     /protein_start="14"
                     /score="287.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LKRVADSPDRQAFAHPAPDDSGPVWLTWEQVGQRAKAIAAGLHGL
                     GVGLENPVAILANTRLEWVLADFGIMCAGGATTTVYPTTEPDDAVYIIADSGSKVLFAE
                     NPAQAAKIAGADLPALTHVVLFDGAPDPAAAVPQLTLAELEERGAAALSAEPDLIDMLV
                     AGIGPDHLATLIYTSGTTGRPKGVELLHGGWCWEGVAQAELGLLRTDDLQYLWLPLSHS
                     FGKTLLCGATHVGLPTYVDGRVDKLVDLLGVIRPTLMCGAPRVFEKVYNKAVTTAQGAG
                     GAKAKIFAWGVEVGKEKVALEQAGKPVPAGLRMKYALAEKLVFSKLQARLGGRMRVLVS
                     GAAPLSKEIATFFAAANLPISEGYGLTETSAGAFVNPPDGLKIGSVGRAMGDLECRIDT
                     DGEILMRGKPVMRGYHNLPEETAAAFTEDGFFRSGDIGTLDDDGYLRITDRKKDLVKT"
     CDS_motif       complement(8545..8619)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R25_RS00720_0002"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="A4R25_RS00720"
                     /protein_end="439"
                     /protein_start="414"
                     /score="24.2"
                     /tool="antismash"
                     /translation="GEILMRGKPVMRGYHNLPEETAAAF"
     CDS_motif       complement(9247..9306)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R25_RS00720_0001"
                     /evalue="2.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="A4R25_RS00720"
                     /protein_end="205"
                     /protein_start="185"
                     /score="23.3"
                     /tool="antismash"
                     /translation="ATLIYTSGTTGRPKGVELLH"
     misc_feature    complement(9891..9906)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.38"
                     /tool="antismash"
     gene            complement(10001..10951)
                     /locus_tag="A4R25_RS00725"
     CDS             complement(10001..10951)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287567.1"
                     /locus_tag="A4R25_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase"
                     /protein_id="WP_043331108.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-75, bitscore: 252.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDFALSALHEPPFPSRCHPAADEVAAQSVAWVRGFGLVKTQAGL
                     LRLAGAHASELAGRACPEASPAGLRLLTDLINWLFVVDDACDDDGLGAAPTVLAPTLAA
                     LLEVLDRHGDPDAPAPTDAGPMGLALHDLCRRARGRGRPAHLMRLVSQLREYLLALLWE
                     AANRERRRVPGVAEYVQMRRHTGGVRPSFTVTDLARPSLPRADQRATPALTALDALATD
                     LVCWCNDVFSYGKERGVTPDAHNLVTTIAGETGQDESAALNAAANRFNAALASYAERDA
                     ALSAGADEGMRAFLDTRRDWIRATYDWSRAASRYA"
     misc_feature    11013..11024
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.1"
                     /tool="antismash"
     gene            complement(11080..11709)
                     /locus_tag="A4R25_RS00730"
     CDS             complement(11080..11709)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183502.1"
                     /locus_tag="A4R25_RS00730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR03085 family metal-binding protein"
                     /protein_id="WP_030500278.1"
                     /transl_table=11
                     /translation="MPRYARTEREALADLMLELGPDAPTVNEGWTTRDLAAHLLVRERR
                     PDAAGGILLPPLRGYGESVRRRIAAGPYADLIARVRRPPVWSPVSNPLTDEIANGMEFF
                     IHHEDVRRARPGWQPRDLPAGQQAVLWKRVALLARMALRRFPAEVLVQAPGHGELRAGG
                     GGERLRLVGAPGELVLFLTGRQRVARVQVDGPAERAERLRTAELGL"
     misc_feature    11792..11808
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            11903..13771
                     /locus_tag="A4R25_RS00735"
     CDS             11903..13771
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020215714.1"
                     /locus_tag="A4R25_RS00735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_197494836.1"
                     /transl_table=11
                     /translation="MASGTSRDVLGRGLRVLGRAIREQPRIFAVAVSGSVLFGLLVIAS
                     AYVVGGVVGKVVVPAVERGEVARGTLALAAAALLGISVLRVVGIFGRRLGAGYMQYRLQ
                     AAYRRRVTRRYLELPLAWHHRNSTGTLLSNANSDVEAAWYPIAPLPFAVGTLVMLVGAV
                     ASLFVTDWALALVGLAVFPALFALNVVYSRRMAPRQARAQRLRAEVSGIAHESFDGALV
                     VKTMGREAQETARFAARAGELRDALISVGRLRGVFDPMLETLPSLGTLAVLVVGAIRLR
                     QGAITVSELVSVAFLFTVLAFPVRAIGWVLAELPRSVAGWDRVRRVLDATGEMPYGTRT
                     LDPATRTPATLAFHDVHFAYEPAEAHLPGAQVLGEVTFTVPAGKTVALVGPTGSGKSTI
                     ASLAVRLVDPGAGRVTLDGVDVRELTAASLAGNVALVAQVPFVFDDTVRANIALDRAGI
                     GDDEVWAALRLAEADGFVAALPDGLDTMVGERGTSLSGGQRQRLTLARALAGRPRLLVL
                     DDATSAVDPRVEAAILAGLRAPADGGAPASILVVAYRRATIALADEVIYVEQGRVVARG
                     AHTELLATVPGYADLVTAYEQAEQEREHKQTYDEVTPLASGLEVER"
     gene            13768..15558
                     /locus_tag="A4R25_RS00740"
     CDS             13768..15558
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475811.1"
                     /locus_tag="A4R25_RS00740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_043329513.1"
                     /transl_table=11
                     /translation="MSATTAEADRSTETTESTWQTLRRGLALSPELRTGLAGTLALALV
                     YMVGRVAVPVAVQRGIDHGIVGGLDLNVISLTVAITAGVLVVTTACGYLMMRRLFTVSE
                     TALAGVRTRAFRHVHDLSMLHQQSERRGSLVSRVTSDVDQITQFLQWGGVILIVNLGQL
                     LVTTAVMLAYSWQLTLVVLVAFAPAVLVIRQLQRRLAGAYGLVRQRTGTLLGAIGESVV
                     GAPVIRAYGIAGRTARRLDTAIDGQRVAQQRAIRISIMGSSVGELAAGLALAGVVVVGV
                     SLGVDRTLSVGQLTAFLFLVTLFIQPVQIATEVLNEAQNAIAGWRRVLDVLDVSPDVAD
                     PGEQGRELPPGPLDARFAGVTFAYPGGPPVLHDVTLDIPAKSRVAVVGETGSGKTTFAK
                     LLTRLMDPTEGAVLLSGVDLRQVRFDSLRSRVVMVPQDGFLFDATVGENVRFARPDLTD
                     ERLTAAFGELGLADWLDGLPSGLDTPVGERGEALSVGERQLVALARAYVADPDLLVLDE
                     ATSAVDPATEVRLQRTLDAVTRGRTTLAIAHRLSTAQAADEVIVVDRGRIVQRGPHDEL
                     VRDTDSVYALLYASWLEQTR"
     gene            complement(15563..16171)
                     /gene="rpsD"
                     /locus_tag="A4R25_RS00745"
     CDS             complement(15563..16171)
                     /GO_component="GO:0015935 - small ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_function="GO:0019843 - rRNA binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012015561.1"
                     /locus_tag="A4R25_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="30S ribosomal protein S4"
                     /protein_id="WP_064445248.1"
                     /transl_table=11
                     /translation="MNHPRPKARLSRALGIPLTRKCVRYFERRPYPPGVHGRSRRTTSD
                     YQVRLLEKQRLRHQYNVSEAQLRRLFDEAARAAGKTGDTLVALLERRLDAVVLRAGLAR
                     SIYQARQLVGHGHITVDGRKVDRPSYRLRPGQVVGVRERSRTLPPFQLAAAGAHADAQP
                     RPYLSAQPAQLRATLVREPARHEVPVVCDEQLVVEFYSR"
     misc_feature    complement(16202..16220)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: strong, score: 32.19"
                     /tool="antismash"
     gene            16239..16973
                     /locus_tag="A4R25_RS00750"
     CDS             16239..16973
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785219.1"
                     /locus_tag="A4R25_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2470 domain-containing protein"
                     /protein_id="WP_064445249.1"
                     /transl_table=11
                     /translation="MRPSPAEIVRTLVAGRLPALVHLARHPGPHQVRHAVDPDGRVLLL
                     VPVVSDLAAALVPPAGDADVAAVLDVLDLPPAAGAPSLGRAWVSGWATRLNGDAARDAA
                     VDFAATDPVADLLDVGSRFHLHRFEVAEARWERAGRVRRIDPEAFAEAEPDPLHPVEAA
                     LLADLADHHAEQVGDYLRRRLDLPGDQIPRVVRIDRYGLLVAHGRPGATRRARLAFPRP
                     VADVAELSRLLHPMLCPRAAAA"
     gene            complement(16985..17581)
                     /locus_tag="A4R25_RS00755"
     CDS             complement(16985..17581)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287561.1"
                     /locus_tag="A4R25_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_030500283.1"
                     /transl_table=11
                     /translation="MNARRTGRRPGTPDTREAILAAAREAFAERGFDAASIRAIAAAAG
                     VDPALVHHYFGGKEELFRAATAFPADPGRLLPAVLAGGPDALGERMVRVFLEVWDSPTG
                     TAAVALLRSAVSNDWTARLLREFLVTQVLRRVLDQLDVDPAQRALRGGLVATQLAGLAM
                     MRYVLRLDAVATAEPATLVAAVGPTVQRYLTGDIT"
     gene            complement(17578..18333)
                     /locus_tag="A4R25_RS00760"
     CDS             complement(17578..18333)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014389.1"
                     /locus_tag="A4R25_RS00760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_043329516.1"
                     /transl_table=11
                     /translation="MNGRILAATTGRILRQLRHDRRTVALLVVVPSVLLTLVYFMYVDQ
                     PAPPGAPSTFDRVALIMLGFFPFIIMFLVTSIAMLRERTTGTLERLLTTPLGKLDLLFG
                     YGIAFGLAGVLQSTVASVVAYQVFGLETAGSAWLVVLIAGVNAVLAVALGLFCSAFART
                     EFQAVQFMPVVVAPQLLLCGLFVPRDQMAGWLQAVSDALPLSYAVEALQEVGAHAEPTG
                     TMWRDVAIVTGAAVAALVLAAATLRRRSG"
     gene            complement(18330..19052)
                     /locus_tag="A4R25_RS00765"
     CDS             complement(18330..19052)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287559.1"
                     /locus_tag="A4R25_RS00765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_043329517.1"
                     /transl_table=11
                     /translation="MDDAVSVRELVVDRGGRRVLHGITCGVPRGTVTGLLGPSGSGKTT
                     LMRAVVGVQTVGSGAVDVLGRPAGSADLRRRVGYLTQAPSVYADLTVRENARYFAVLQG
                     RGRAEADRAVTDVGLGKAADQLVGTLSGGQRSRASLACALVGEPELVVLDEPTVGQDPV
                     LRADLWARFHAMAAAGTTLLVSSHVMDEAARCDRLLLIREGRLVADDTPAAVRAATGTD
                     DLEEAFLRLIRDAEGEAR"
     gene            19163..19552
                     /locus_tag="A4R25_RS00770"
     CDS             19163..19552
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287558.1"
                     /locus_tag="A4R25_RS00770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_064445250.1"
                     /transl_table=11
                     /translation="MDISTRETSLTVGEAAERVGLTTYTLRWYEQEGLVGRVGRDSSGR
                     RRYTESDVNWLFLLTRLRRTGMPVRDMRRYAELARHGDSTLGARRALFEAHRARVLARM
                     AELEEDLKVLEHKIDAYRRAEEESG"
     gene            19703..>20350
                     /locus_tag="A4R25_RS31625"
                     /pseudo=""
     CDS             19703..>20350
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037778.5"
                     /locus_tag="A4R25_RS31625"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLRGSHARRAATEHSDVDVDVLVAADEPRATGGPRPVTSRRGTPY
                     AARRAYLTEFGGRLVHVSVAARDVRSWVRRLGQPADWAFGLPVTAPARLLWAVPEWRRR
                     IDLPVLCQPADEPRLEELIATLGKVAAARLAGDPVGVRLAAADLARLCPSVLRPANPSV
                     RVVSRRAALTAALDLPVAPPGYRDDMLLCLGLRPGDPAEVGAAAGRLVTGILP"
     misc_feature    complement(20400..20414)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            20531..20944
                     /gene="hisI"
                     /locus_tag="A4R25_RS31630"
     CDS             20531..20944
                     /EC_number="3.5.4.19"
                     /GO_function="GO:0004635 - phosphoribosyl-AMP
                     cyclohydrolase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072124.1"
                     /locus_tag="A4R25_RS31630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoribosyl-AMP cyclohydrolase"
                     /protein_id="WP_043331113.1"
                     /transl_table=11
                     /translation="MPAPDAPLTGAPSPGPARPSRLDPAIAAKLRRTPDGLVAAVVRAH
                     DTGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQYVRSVALDCDGDA
                     LLVSVEQVGAACHTGQRTCFFTDLPVSSPEETP"
ORIGIN
        1 acgcggcgct ggcctggcag tccgacggcg cggagtggat ccatctggtg gatctggacg
       61 ccgcgttcgg gcggggctcc aacgccgcgc tgctggccga ggtggtcggc aagctggacg
      121 tgaaggtgga gctgtccggt ggcatccgcg acgacgagtc gctgcgggcg gcgctggcca
      181 ccggggcggc gcgggtgaac atcggcaccg ccgcgctgga ggatccgcag tggtgcgacc
      241 ggatctgcgg cgagtacggc gaccgggtgg cgatcgggct ggacgtgcgc ggccgtaccc
      301 tgtcggcgcg cggctggacc cgcgacggcg gtgacctgta cgaggtgctg gcccggctgg
      361 acgcggcggg cgcggcgcgg tacgtggtca ccgacatcac caaggacggc accatgcgcg
      421 ggccgaacct ggacctgctg cgcgaggtgt gtgcccgcac cgacgccccg gtgatcgcct
      481 ccggcggcgt gtccacgctc gacgacctgc gggcgctggc cacgctggag ccggtgggcg
      541 tggagggcgt gatcgccggg aaggcgctct acgcgggcgc gttcaccgtc gccgaggcgc
      601 tggcgacgct gcgggccggc gcgtgaccgc cgcgccgccc gagccgccgg cggacgccgg
      661 tgtggtgacc cggctcggct cgggcggccc gtgggaggcg ctgtacggct actcgcgggt
      721 ggtccgggcc ggttcgctgg cgatcacggc cggctgcacc tcgactgtgg acggccgggt
      781 ggcgcacgcc ggcgacgcgg cggcgcagac cgcgcaggcg atccggatcg gcctggacgc
      841 gctggccgag gtgggcgccg gtccgggcga cgtggtgcgg acccggatgt acgtgacgga
      901 ccggatcttc gccgacgagg tgggccgggc gcacaacgcg gtgttcggcc cggtacgccc
      961 ggtggcgacg atggtggtgg tggccgggct gatcgacccg gacctgctgg tcgaggtcga
     1021 gctggaggcg tacctccccg cctgaggcgg tccggggtgc ctcgcgcgcc ccggaccaca
     1081 cgccgatcgg ttgtgcgcaa cttaattgtg cgttacggtt ccacggtgac cgatgatctg
     1141 gtgctgcgcc ggcaggtgtg cttcgccctc tacgcggcgt cgcgcgccat gaccgacgtc
     1201 taccggccca tcctcgacga gcgcggcctg acctacccgc agtacctggt gctgctggtg
     1261 ctctgggagc gtgacgacga cgcccccacg gtctccgagc tcggcgccgc gctccggctc
     1321 gactccggca cgctctcccc gctgctcaag cggctggagg cggccggcct ggtggtgcgt
     1381 acccgctcgg ctgccgacga gcgccgggtc gaggtgggcc tcaccggcca gggccgggcc
     1441 ctgcgggagc ggatgtgtga cgtgccgcgg caggtggcca ccgccaccgg gctcaccgag
     1501 gccgaactgg tcttcctcca cggcatcctc acccgggtca ccgagacgat ccaccgacag
     1561 aaggagcagt gacatgcagg tgctctacac cgcctccgcc cgcgccaccg gcgacggccg
     1621 cgacggtcac gtccgcacct ccgacggcac ggtcgagctg gacctcgccg taccgaagga
     1681 gatgggtggc gccggcggcg cggccaaccc ggagcagctc ttcgcggccg gctacgcggc
     1741 ctgcttccac tccgcgctgc gcgtggtcgc ccgcaaggcc aaggcggacg tctccggctc
     1801 ggtggtcgag gccgaggtgg gcatcggccc gaacggcagc ggcggcttcg gcctcgccgt
     1861 gacgctcgtg gtggacctgc ccgcggtcga gcgcgcggcc gccgagcagt tggtcgacgc
     1921 ggcccaccag gtctgcccct actccaacgc gacccggggc aacgtcgagg tcacccgcac
     1981 ggtccgcgag gcccgatgag cgggatgaac cgggagatcc atctggcgtc ccggccgcag
     2041 ggctggccga ccgcggagaa cttccggctg gtcaccaccg aggtgccgac gccgggcccg
     2101 gggcaggtgg tggtccgcaa ccggttcatg tccgtcgacc cgtacatgcg cgggcggatg
     2161 aacgacgtca agtcgtacgt gccgccgttc gcgctcgacg ccccgctcga cgggggcgcg
     2221 atcggtgagg tggtggccgg cgaggccggc ggcgtcaagc ccggcgacac ggtgctgcac
     2281 gggctgggct ggcgcgagta cgcgctggtg gacgccaagg gcgcgcgcaa gatcgacccg
     2341 gacctggcac cggtgaccgc ccatctgggc gtgctcggca tgaccgggct gaccgcgtac
     2401 gccgggctgc tcgacgtggc cgccatgaag ccgggggaga ccgtcttcgt ctccggcgcg
     2461 gccggcgcgg tgggcagcat ggtcggccag atcgcgaagc tgcgcggcgc cggccgggtg
     2521 atcggcagcg ccggctccgc ggcgaaggtg gaacggctca ccgcgctcgg cttcgacgcc
     2581 gcgttcgact accacgacgg cccggtgtcc aagcagctca gggcggccgc gccggacggc
     2641 gtcgacgtgt acttcgacaa cgtcggcggc gaccacctgg aggccgcgat cggggcgatg
     2701 aacgtgcacg gccgggccgc catctgcggc atgatcgcgc agtacaacgc caccgagccg
     2761 ccggccgcgc cgcgcaacct ggcgctggtg atcggcaaac gcctgacgct gcgcgggttc
     2821 ctcgtcagtg accacggtca cctgcgggag cagttcgtgc aggaggtggc gggctggctg
     2881 cgcgagggcc ggctgtcgta cgacgagacg atcgtcgacg gcatcgagca ggccccggag
     2941 gcgttcctcg gcctgctgcg cggcgagaac ctcggcaaga tgctggtccg tctctgaccg
     3001 gcgtgaaccc gtaccaccac gggcggtggt gaccggcctc accggcgggt caccaccgcc
     3061 cgcgcgttgg ctaggctcgg ggcatgacgg tggcggtacg ggtcatcccg tgtctggacg
     3121 tggacgccgg gcgcgtggtc aagggggtca acttcctcga cctgcgcgac gcgggcgacc
     3181 cggtggagct ggcggcggcg tacgaccggg ccggcgcgga cgagctgacc ttcctcgacg
     3241 tcaccgcctc gtccagtgac cgcggcacca tgctggacgt ggtgcggcgt accgccgagt
     3301 cggtcttcat cccgctcacc gtgggcggcg gcgtccgcca ggtcgccgac gtcgacacgc
     3361 tgctgcgggc cggggcggac aaggtgggcg tgaacaccgc cgccatcgcc cgcccggagc
     3421 tgatcgccga gatcgccgac cggttcggca gtcaggtgct ggtgctctcg ctggacgtgc
     3481 gccgcgcgcc cgacggcacg acgccgagcg gtttcgaggt gaccacgcac ggcgggcggc
     3541 ggggcaccgg gctggacgcg gtcgagtggg cggcgcgcgg cgccgagctg ggcgcggggg
     3601 agatcctgct caactcgatg gacgccgacg gcaccaaggc cgggttcgac ctgccgctga
     3661 tccaggcggt ccgggaggtg gtcgacgtgc cggtgatcgc cagcggcggc gcgggcgagg
     3721 tggcgcactt cccgccggcc gtcggcgcgg gggcggacgc ggtgctcgcg gcgagcgtct
     3781 tccacttcgg tgagctgacc gtcggcgagg tcaaggacgc gctgcgcggc gccgggcacc
     3841 cggtgcgctg aggcgcgctc actgccggcc ggagtgcccc tcgggggagc ggcgcggcat
     3901 cgggatcgag cggaccacgt actcctgcac ggcggcggcg tgatcgtcct cgtcgagctg
     3961 ccactcggac tcaccgggcg ggtgccggcg ggtcagcacg ccctgcacgg tgtccacagt
     4021 ggtgccgagc ccggcgctgg ggcgggtgcg ccagagccgc tcaccgtccg gtgtgacccg
     4081 gaaccagccg tcggcgacgc tgaccaggcc cgcgccgacg agccgccgga ccgcgccctc
     4141 cacctcgtgc cgctcgggga tggcctggtt gaggtggtcg gcggtggaga ggacgtcggc
     4201 cagtcgtacg ccttcggggc ggcgtgtcga cgcggaccgc cggtgccggc cggcgccact
     4261 ggcgatgaca agcgcgacga agatccaggc gtcgctccaa cgccatccgt tctcccccat
     4321 gcaggaatga tgcccggccg cgacggcgga ggaaacacct ggttttgctg ttcttcgtca
     4381 ccgcagctca gcgcgttgcg gatcgcttcg ggccgtggcg gtcggcccgg cgccggtcac
     4441 gtagcgtaag cgccgctcgc cggacgtgcg ggcagcgcga agaccgggat gaagaactgg
     4501 gcgagcgggc cgatggtcag cgcgtacgcc acggtgccga ggccgacggt tccgccgagc
     4561 agccagccga gggccagcac ggtgacctcg atgctcgtgc ggaccagccg caccgagaag
     4621 cggggatgac gggcgacgaa tccggtcatc agaccgtcgc ggggcccggg gccgagcccg
     4681 gcgccgaggt agagcccggt ggcggcgccg ttggcgacga tcccggccac gagcatcgcg
     4741 gcacgcgccg gcatgccctc accgggcggc agcacggcca gggtggcgtc gacgaccagg
     4801 ccgatgacca cgacgttgct gaccgtgccg aggccgggcc gctgccgcag cgggatccag
     4861 agcagcagca cgagagcgcc gacggcgatg gtgacggtgc cgaaggagag accggtctgc
     4921 cgggcgagcc cctggtggaa cacgtcccac gggtccagcc ccagctccga ccggatcatc
     4981 agcgccatgc tgaggccgta caggacgagc ccggcgtaga gctgggtgag tcgtcgagcc
     5041 gaacggtgcc cgagattgcc aagcggtgcc atgcatgcca ccctaggggc caattgcagg
     5101 acgtaagggg tccaatttcg gaggtgtggc catgaccagc caggtgcgcg gcgtccaatt
     5161 ggcgcgactc ctcggccagt ggcatgcgct gccgggccgc cgccgcagcc ccgactacgc
     5221 cgcgctcgcc ggcgccgtcc ggggcctgct cgccgacggc cggctgcccc tgggggtacg
     5281 cctgccggcc gagcgggaac tggccgaggc gctgcggatc agccggacca ctgtcaccgc
     5341 cgcgtaccgg gaactgcggg agagcggcca cctggccagc cgccggggcg ccgggagctg
     5401 gaccatgctg cccggcggcc accgggtcgc cagcaccggg ctgtggacgc cgctggacga
     5461 ccgcgacatg atcgacctcg gcgtggccgc gctgtccgcg ccgccgcagc tcgtcccggc
     5521 cgcccgggcg gccgccgagg acctgccccg ctacctcggc ggggccggct accacccgac
     5581 cggcatcatc gagctgcggg aggcggtggc ccgcgggtac accgagcgcg ggctgcccac
     5641 cagcccggag cagatcatgg tcaccagcgg cacccagcac gcgctggacc tggtgctgcg
     5701 gctggccctg tcgcccggtg gcgcggtgct cgtcgagtca cccacctacc ccaacgcgct
     5761 ggccgcgctg gccgcccggc gcgcccggat cgccacgcac ggcctgtccg acgagggctg
     5821 ggacgccgag ctgctgctcg gcagcatccg gcagacccgg ccgaagctcg cgtacgtgat
     5881 cccggagttc cacaacccga ccggccacct gatggcggcc gacctgcgcg aacggctggt
     5941 cggcgcggcc cacgcggccg gcaccgacct cgtcgtcgac gagtccttcg tcgacctgcc
     6001 gctggacggc accccgctgc cgccgccggt cgcggtcttc gacaggcact cccgggtgat
     6061 cagcatcggc gggatgagca agccctactg gggcggcctg cggatcggct gggtccgcgc
     6121 ctccgcgccc caggtgcagc ggctcgccgc ggcccgggtc ggggtggaca tggccagccc
     6181 ggtgctcgac cagctcgtcg ccgtgcacct gctcgccgag gcgccggcca tcgtggccgc
     6241 ccgccgggcc cagctcgccg cgcagcgcga cgccctggtc gcggcgctcg cggagcagct
     6301 gcccgactgg cgggtcacgc cgccgcgcgg cggcgtgacg ctctgggccg agctggacgg
     6361 cccgatctcc agcgcgctgg cccgggccgc cgaggaggtc ggcgtacggc tggcgcccgg
     6421 accccggttc ggcctggacg ggacgctcga gcgcttcctg cggttgccct tcacgctgcc
     6481 cgccgaggaa ctggtggaag cggtgggccg gctcgccgcg gtgcgctacg acctggaccg
     6541 caccagccgc ccgcagtggc gcgagccgag cgtcatcgcc tgaccgcccg cccgatccgg
     6601 tggtgaaccg cccgaaccac agctgcgggc gggtccgcgc ccgcacactg cccgggtggg
     6661 agacggggac gcggtccggt ggtcgtgggc ggtgcagcgc agcgcgccgg gctcccgcac
     6721 cacccggctg gagctcttct acgacctggt cttcgtcttc gcgttcctga gcgtcaccac
     6781 gctcaccgcc tcggtgctca cgcccgccaa cctctaccgg ttcctgctgg tgctggcgct
     6841 gctctggtgg tcgtggaccg gcttcgcccg gatgggcaac gcgttccgcg ccgaccaggg
     6901 gatgctgccg ctgatcggcg tcgtcaccgt ggcggccacg ttcctgctcg tgctcagcac
     6961 gcccagcgcg ttcgccaaca gcggtggctg gctgcccggg ccgctggtct tcgccgcgtg
     7021 ctacttcgtg atccggaccg cccagctcac cgtcttcgcc tgggccgacc gcgccgaccc
     7081 ggcccggcgc cggggactgc ggatgcgctt cctggccccg acggtggcca cggcgctgct
     7141 tgtcgtcgcc ggcacactcc ccggccggct gccgcaggag cggttcgcgg tcgggctgca
     7201 actggcgctc tggacgctgg cgctgcttgt cgagtacgtc gccgggacgg tcctgggcca
     7261 gcagtggtgg gtggtgctct cggccgggca ctgggcggaa cggcacgcgc tcatcgtgct
     7321 cgtcgcactc ggcgagtcga tcatcgcgct ggggctcggc ccgaagcgcg ggctgccgct
     7381 caccggcccg gtggcgatcg ccgcgttgct cggcatcacg gtcgtggcgg cgctgtggtg
     7441 ggcgtacttc gacacgctgg cgttcgccat ggaacaggtc ctgcaccagg cccgggaccg
     7501 cgccacacgg ctgcggctgg cccgcaccgc gtacacgttc ctgcacctgc cgatagtcgc
     7561 cgggatcatc ctctacgcgc tcggcctcaa ggacctgctg gccgaggccg ccgatccgca
     7621 cacgcccgcc tgggggctgc cgctcggcga cttctggggc gcgatcctgt tcggcggggt
     7681 cgcgttgcac ctgctcggcg tcgccgggtg ctggtgggtg gcgctgcgcg agatccactg
     7741 gcggctgctg accaccgtgg gggcgctgac cgcggtcgcc ccattcgtgt tccgtgtgcc
     7801 ggagctggtc gcgctgatcg tgctggcggt ggtcaccggc gcgggagtgg cctgggagac
     7861 ccggggcgag aacggtcacc ggcgccgggt acgccagctc gcgctggagg agcagatcgc
     7921 cgccgaggcc gagcagagcc gctggcggca gcagcacctc tgaccggcgc cgacgcgaac
     7981 ggccgtgccc cgggacggtg gggcacggcc ggcgctaccg gctggcggtg cgggtcacag
     8041 ctcggcgagc gtgccctcgt acatcttgtc gatctcggag gagaagttcg tctccacgct
     8101 ccggcgcttg atcttcagcg acggcgtgac ctcgccgtcc tcgatggtga ggtcacgggg
     8161 gaggatcgtc accttcttga tcgtctccca gcggttgagc ttggcgttca gctcggcgac
     8221 gtacccctcg accatctccc gcgcctgcgg cgaggtgacg atcgtggtgt agtcgctgcc
     8281 ctccagcggg gtgccggcgg cccagccctt gatcgcgtcc gggtccagcg tgacgagcat
     8341 ggtgcagtag ttgcgcgcct gcccgatcac caccgcctgc gaggtgtacg ggcagaccgc
     8401 cttgaacatg ccctcgatgt gcgacggcgc gacgtacttg ccgccggacg tcttgaccag
     8461 gtccttcttg cggtcggtga tgcgcaggta gccgtcgtcg tcgagcgtgc cgatgtcgcc
     8521 gctgcggaag aagccgtcct cggtgaacgc ggcggcggtc tcctcgggga ggttgtggta
     8581 accccgcatg accggcttgc cccgcatcag gatctcgccg tcggtgtcga tccggcactc
     8641 cagatcaccc atggcccggc ccacgctgcc gatcttcagc ccgtcgggcg ggttcacgaa
     8701 cgcgccggcg ctggtctcgg tcaggccgta gccctcggag atgggcaggt tggcggcggc
     8761 gaagaaggtg gcgatctcct tgctcagcgg cgccgcgccg gagaccagca cccgcatccg
     8821 gccgccgagc cgggcctgca gcttgctgaa caccagcttc tcggccagcg cgtacttcat
     8881 ccgcagcccg gccggcaccg gcttgccggc ctgctccagc gcgaccttct ccttgccgac
     8941 ctcgacgccc caggcgaaga tcttggcctt cgcgccgccc gcgccctgcg cggtggtgac
     9001 cgccttgttg tagaccttct cgaagacccg gggcgcgccg cacatcagcg tcggccggat
     9061 cacgccgagc aggtcgacca gcttgtccac ccggccgtcg acgtacgtgg gcaggccgac
     9121 gtgggtggcg ccgcagagca gcgtcttgcc gaacgagtgc gacagcggca gccacaggta
     9181 ctgcaggtcg tcggtgcgca gcaggcccag ctcggcctgc gccacgccct cccagcacca
     9241 gccgccgtgc agcagctcca cgcccttcgg gcggccggtg gtgcccgagg tgtagatgag
     9301 cgtcgccagg tggtccgggc cgatgccggc cacgagcatg tcgatcaggt cgggctcggc
     9361 gctcagcgcg gcggcgccgc gctcctccag ctcggccagg gtgagctgcg ggacggcggc
     9421 ggccgggtcg ggcgcgccgt cgaagagcac cacgtgggtc agcgcgggca ggtccgctcc
     9481 ggcgatcttc gccgcctggg ccgggttctc cgcgaacagc accttcgagc cggagtcggc
     9541 gatgatgtag accgcgtcgt cgggctcggt ggtcgggtag acggtggtgg tggccccacc
     9601 ggcgcacatg atgccgaagt cggccagcac ccactccagc cgggtgttgg ccaggatcgc
     9661 caccgggttc tccaggccga caccgagccc gtgcaacccg gcggcgatcg ccttcgcgcg
     9721 ctgcccgacc tgctcccacg tcagccagac cgggcccgag tcgtcgggtg cggggtgagc
     9781 gaacgcctgg cggtcggggg agtccgccac gcgcttgagg aacatgtcgg gtacggaacg
     9841 gtacggtaca tcgagagcca tcgctgtagc cgccttcagg ggtggaggga cgtgacgggg
     9901 gtcacgccgg tctgcggtta ccgaagggta ttgcctgtac ccggccagcg gctagccctg
     9961 atcggccgag tcgccaccgg tcccgacttc tggaatcgga tcaggcatat cggctggcgg
    10021 cgcgggacca gtcgtaggtg gcccggatcc agtcccggcg ggtgtccagg aacgcccgca
    10081 tcccctcgtc ggccccggcg ctcaacgccg cgtcccgctc cgcgtacgag gcgagggccg
    10141 cgttgaagcg gttcgccgcc gcgttcagcg ccgccgactc gtcctgcccg gtctcgcccg
    10201 cgatcgtggt caccaggttg tgcgcgtccg gggtgacgcc ccgctccttg ccgtaggaga
    10261 acacgtcgtt gcaccagcag accaggtcgg tggcgagggc gtccagcgcg gtgagcgccg
    10321 gggtcgcccg ctggtcggcc cggggcaggg acgggcgggc caggtcggtc accgtgaagc
    10381 tggggcgtac gccgccggtg tggcggcgca tctgcacgta ctcggcgacc ccgggcacgc
    10441 gccggcgctc ccggttcgcc gcctcccaca gcagcgccag caggtactcc cgcaactggc
    10501 tcaccagccg catcaggtgc gccggccggc cccggccgcg cgcccgccgg cacagatcgt
    10561 gcagcgccag gcccatcggg ccggcgtcgg tgggcgcggg cgcgtccggg tcaccgtgcc
    10621 ggtcgagcac ttccagcagc gccgccaggg tgggcgcgag caccgtcggc gcggcgccca
    10681 gcccgtcgtc gtcgcaggcg tcgtccacca cgaacagcca gttgatcagg tcggtgagca
    10741 gccgcagacc ggccggggac gcctcggggc aggcccgtcc ggccagctcc gaggcatggg
    10801 cgccggccag ccgcagcagg ccggcctggg tcttgaccag gccgaaaccg cgcacccagg
    10861 cgacgctctg cgcggccacc tcgtccgcgg ccgggtgaca ccgggaggga aagggcggct
    10921 cgtgcagcgc cgagagcgcg aagtcccgca tcgtcgtccc ctgtccgccg ccccgcaggg
    10981 tcgggccggt gcgcaggagc gtacggcagc cggcgaacgt tatcgaacgc cgggtgtcca
    11041 cattctacga tcgcctgggt gggcgggcgg aaacgtctgt cacaggccca gttcggcggt
    11101 acgcagacgc tcggcgcgct cggccggacc gtccacctgg acccgggcca cccgctgccg
    11161 cccggtgagg aacagcacga gttcccccgg cgcgccgacc agccgcagcc gctcgccgcc
    11221 gccaccggcc cgcagctcgc cgtgccccgg cgcctgcacc agcacctcgg ccgggaagcg
    11281 ccgcagcgcc atccgggcca gcagggcgac ccgcttccag agcaccgcct gctgcccggc
    11341 cggcaggtca cgcggctgcc agcccggccg ggcccggcgg acgtcctcgt ggtggatgaa
    11401 gaactccatc ccgttcgcga tctcgtcggt gagcgggttg ctcaccgggc tccacaccgg
    11461 gggacggcgg acccgggcga tcaggtcggc gtacggcccg gcggcgatcc gcctgcggac
    11521 cgactcgccg tagccgcgca gcggcggcag caggatcccg cccgccgcgt ccggccggcg
    11581 ctcccgcacc agcaggtgcg ccgccaggtc gcgggtggtc cacccctcgt tcacagtcgg
    11641 cgcgtccggt cccagctcca gcatcaggtc ggcgagcgcc tcgcgctccg ttcgggcgta
    11701 ccgcggcatg gcccgatcgt aggcccgtcg cggccgatcg gcgcgccacg cccggcgcta
    11761 cggcgggccg cgagtatcga gggccggtgt ccgcccaggt ccggtgcgaa cgtgacggcg
    11821 gacatatccc ggccgggtcg gcggagctgg cggcgagcgg taaggatggg ggagaaaatt
    11881 gcggcttacg gcgggggcga acgtggcgag cgggacaagt cgggacgtgc tcggcagagg
    11941 gctacgggtg ctcggccggg ccatccggga acagccgcgg atcttcgcgg tggcggtcag
    12001 cggcagcgtg ctgttcggcc tcctggtgat cgccagcgcg tacgtggtcg gcggggtggt
    12061 cggcaaggtc gtcgtgcccg cggtcgagcg cggcgaggtg gcccgcggga ccctggcgct
    12121 ggccgcggcg gcgctgctcg gcatcagcgt gctgcgggtc gtcggcatct tcggccggcg
    12181 gctcggcgcc ggttacatgc agtaccggct ccaggccgcc taccgccgcc gggtcacccg
    12241 ccgctacctg gaactgccgc tggcctggca ccaccgcaac tccaccggca cgctgctgtc
    12301 gaacgccaac tccgacgtgg aggcggcctg gtacccgatc gcgccgctgc cgttcgcggt
    12361 cggcacgctg gtgatgctgg tcggcgcggt ggcgtcactg ttcgtcaccg actgggcgct
    12421 ggccctggtc ggcctcgccg tgttccccgc gctgttcgcg ctcaacgtgg tctactcccg
    12481 ccggatggcg ccccggcagg cccgggcgca gcggctgcgc gccgaggtca gcggcatcgc
    12541 gcacgagagc ttcgacggcg cgctggtggt caagacgatg ggccgcgagg cccaggagac
    12601 cgcccgtttc gccgcccgcg ccggcgagct gcgggacgcg ctgatctcgg tcggccggct
    12661 gcgcggcgtc ttcgacccga tgctggagac gctgcccagc ctcggcacgc tcgccgtgct
    12721 ggtggtcggc gcgatccggc tgcggcaggg cgcgatcacc gtgtccgagc tggtcagcgt
    12781 cgcgttcctg ttcaccgtgc tggccttccc ggtgcgcgcc atcggctggg tgctggccga
    12841 gctgccgcgt agcgtcgccg ggtgggaccg ggtgcgccgg gtgctcgacg cgacaggcga
    12901 gatgccgtac ggcacgagga cgctcgaccc ggccacccgt acgccggcca cgctcgcgtt
    12961 ccacgacgtg cacttcgcgt acgagccggc cgaggcgcac ctgcccggcg cccaggtgct
    13021 cggcgaggtg acgttcaccg tgccggccgg gaagaccgtc gccctggtcg ggcccaccgg
    13081 ttcgggcaag tccacgatcg cgtcgttggc cgtgcgcctg gtcgacccgg gcgccgggcg
    13141 ggtcacgctg gacggcgtgg acgtgcggga actgaccgcc gcctcgctcg ccggcaacgt
    13201 ggcgctggtg gcgcaggtgc cgttcgtctt cgacgacacg gtccgggcca acatcgcgct
    13261 ggaccgggcc ggcatcggcg acgacgaggt gtgggcggcg ctgcggctgg ccgaggcgga
    13321 cggcttcgtg gccgcgctgc cggacgggct ggacaccatg gtcggcgagc ggggcacctc
    13381 gctgtccggc gggcagcggc agcggctgac gctggcccgg gcgctggccg ggcgcccccg
    13441 gctgctggtg ctcgacgacg ccacgagcgc tgtcgacccg cgcgtcgagg cggccatcct
    13501 ggccgggctg cgcgcgcccg ccgacggcgg cgccccggcg tcgatcctgg tggtggcgta
    13561 ccgccgggcc accatcgcgc tcgccgacga ggtgatctac gtggagcagg gccgggtggt
    13621 cgcccgcggc gcccacaccg agctgctggc caccgtgccc ggctacgccg acctggtcac
    13681 cgcgtacgag caggccgagc aggaacgcga gcacaagcag acgtacgacg aggtcacgcc
    13741 gctggcctcc ggcctggagg tggagcggtg agcgcgacga cggcggaggc ggaccggagc
    13801 accgagacca ccgagtcgac ctggcagacg ttgcggcgcg ggctggcgct ctccccggag
    13861 ctgcgcaccg gtctcgccgg cacgctcgcg ctggcgctgg tctacatggt cggccgggtc
    13921 gccgtgccgg tggcggtgca gcgcggcatc gaccacggca tcgtcggcgg gctcgacctg
    13981 aacgtcatct cgctcaccgt ggcgatcacc gccggggtgc tggtggtcac caccgcctgc
    14041 ggctacctga tgatgcgccg gctgttcacg gtgagcgaga cggccctggc cggggtgcgc
    14101 acccgggcgt tccggcacgt gcacgacctg tccatgctgc accagcagtc cgagcggcgc
    14161 ggctcgctgg tctcccgggt gaccagcgac gtcgaccaga tcacccagtt cctgcagtgg
    14221 ggcggcgtga tcctgatcgt caacctgggc cagctgctgg tgaccacagc ggtgatgctc
    14281 gcgtactcct ggcagttgac gctcgtggtg ctcgtcgcgt tcgcgccggc ggtgctggtg
    14341 atccggcagt tgcagcgccg cctcgccggg gcctacggcc tggtgcggca gcgcaccggc
    14401 acgctgctcg gcgcgatcgg cgagagcgtg gtgggcgcgc cggtgatccg ggcgtacggc
    14461 atcgccgggc ggaccgcgcg gcggctcgac acggccatcg acggtcagcg ggtggcccag
    14521 cagcgggcga tccggatcag catcatgggc agctcggtgg gggagctggc ggccgggctg
    14581 gcgctggccg gcgtggtcgt ggtcggggtg agcctgggcg tcgaccgcac gctgtcggtc
    14641 ggccagctca ccgcgttcct gttcctggtc acgctgttca tccagccggt gcagatcgcc
    14701 accgaggtgc tcaacgaggc gcagaacgcg atcgccggct ggcgccgggt gctggacgtg
    14761 ctggacgtct ccccggacgt ggccgacccg ggcgagcagg ggcgggagct gccgcccggg
    14821 ccgctggacg cccggttcgc cggcgtgacg ttcgcctatc cgggcggccc gccggtgctg
    14881 cacgacgtga cgctggacat cccggccaag agccgggtgg cggtggtggg cgagaccggc
    14941 agcggcaaga ccacgttcgc caagctgctc acccggctga tggacccgac cgagggcgcg
    15001 gtgctgctct ccggcgtcga cctgcggcag gtgcgtttcg actcgctgcg ttcccgggtg
    15061 gtgatggtgc cgcaggacgg cttcctgttc gacgccacgg tcggggagaa cgtccgcttc
    15121 gcccgccccg acctgaccga cgagcggctc accgccgcct tcggcgagct gggcctggcc
    15181 gactggctgg acgggctgcc gtccgggctg gacacgccgg tcggtgagcg cggggaggcg
    15241 ctcagcgtcg gcgagcggca gctcgtggcg ctggcccggg cgtacgtcgc ggacccggac
    15301 ctgctggtgc tggacgaggc gacgagcgcc gtcgacccgg ccaccgaggt acgcctgcaa
    15361 cgcacgctcg acgcggtgac ccgggggcgg accacgctcg ccatcgcgca ccggctgtcc
    15421 accgcgcagg cggcggacga ggtgatcgtg gtggaccggg gccggatcgt gcagcgtggc
    15481 ccgcacgacg agctggtccg cgacaccgac tccgtgtacg cgctgctgta cgcgtcctgg
    15541 ttggagcaga cccggtaacc ggtcagcggg agtagaactc caccaccagt tgctcgtcgc
    15601 agaccaccgg cacctcgtgc cgggccggtt cgcgtaccag cgtggcgcgc agctgcgccg
    15661 gctgcgcgga caggtacggc cggggttgcg cgtcggcgtg cgccccggcg gcggcgagct
    15721 ggaacggtgg cagcgtgcgg ctgcgctcgc gtacgccgac cacctggccg ggccgcagcc
    15781 ggtacgacgg ccggtcgacc ttgcgcccgt ccacggtgat gtggccgtgc ccgacgagct
    15841 ggcgggcctg gtagatgctg cgggccagcc cggcccgcag gaccaccgcg tcgaggcgtc
    15901 gttccagcag cgcgacgagc gtgtcgccgg tcttgccggc ggcccgggcg gcctcgtcga
    15961 acagccggcg caactgggcc tcgctgacgt tgtactggtg gcgcagccgc tgcttctcca
    16021 gcagccgcac ctggtagtcg gaggtggtgc ggcgggaccg gccgtgcacg cccggggggt
    16081 aggggcgccg ctcgaagtac cgcacgcact tgcgggtcag cgggatgccg agggcccggg
    16141 agagccgggc tttgggccgg gggtggttca cgggggcgtc tccgatcgtc tagcctgctt
    16201 cttaggtaag cctaacctat cttgaggagg tcgggatcat gcggcccagc ccggcggaga
    16261 tcgtgcgaac ccttgtcgcg ggccggttgc ccgccctcgt ccacctggcc cggcaccccg
    16321 gcccgcacca ggtccggcac gccgtcgacc cggacgggcg ggtgctgctg ctcgtacccg
    16381 tggtcagtga ccttgccgcg gcgctcgtgc cgccggcggg cgacgccgac gtggccgccg
    16441 tgctcgacgt gctcgacctg ccgccggcgg ccggggcgcc ctcgctcggc cgggcctggg
    16501 tgtccggctg ggcgacgcgg ctgaacgggg acgcggcgcg cgacgcggcg gtcgacttcg
    16561 ccgccaccga cccggtcgcc gatctgctcg acgtgggcag ccggttccac ctgcaccgct
    16621 tcgaggtggc cgaggcccgc tgggaacgcg ccgggcgggt gcgccggatc gacccggagg
    16681 cgttcgcgga ggccgagccg gacccgctgc acccggtcga ggccgccctg ctcgcggacc
    16741 tggccgacca ccacgccgag caggtcggcg actaccttcg gcggcggctg gacctgcccg
    16801 gcgaccagat cccgcgggtg gtccggatcg acaggtacgg cctgctggtc gcgcacgggc
    16861 ggcccggcgc gacccggcgg gcccggctcg ccttcccccg gccggtcgcc gacgtggcgg
    16921 agctgtcccg cctgctgcac ccgatgctct gcccccgggc ggccgcggcc tgagccgcga
    16981 cggctcaggt gatgtcgccg gtgaggtacc gctggaccgt cgggccgacg gcggccacca
    17041 gcgtcgccgg ctcggcggtg gcgaccgcgt cgaggcggag cacgtaccgc atcatcgcca
    17101 gcccggcgag ctgggtggcg accaggccgc cgcgcagcgc gcgctgcgcc gggtcgacgt
    17161 cgagctggtc gagcacccgc cgcagcacct gggtgaccag gaactcgcgc agcaggcgcg
    17221 ccgtccagtc gttgctgacc gccgagcgca gcagcgccac cgcggcggtg ccggtggggg
    17281 agtcccagac ctccaggaac acccggacca tccgctcgcc gagcgcgtcc gggccgccgg
    17341 cgagcaccgc cggcagcagc cgtcccgggt cggccgggaa cgccgtcgcg gcccggaaca
    17401 gctcctcctt gccgccgaag tagtggtgca cgagcgccgg gtccacgccc gccgccgcgg
    17461 cgatggcccg gatggacgcg gcgtcgaacc cccgctcggc gaacgcctcc cgcgccgcgg
    17521 cgaggatcgc ctcgcgggtg tccggagtgc cgggccgccg cccggtgcgc cgcgcgttca
    17581 cccgctgcgc cggcgcagcg tcgcggcggc cagcaccagc gccgccaccg ccgccccggt
    17641 cacgatcgcc acgtcccgcc acatcgtccc ggtcggctcg gcgtgcgcgc cgacctcctg
    17701 cagcgcctcg accgcgtacg acagcggcag cgcgtcgctg accgcctgga gccagccggc
    17761 catctggtcg cgcggcacga acaggccgca cagcagcagt tgcggggcca ccaccaccgg
    17821 catgaactgg accgcctgga actcggtgcg ggcgaacgcc gagcagaaca gcccgagcgc
    17881 caccgccagc accgcgttca ccccggcgat cagcacgacc agccacgcgc tgcccgcggt
    17941 ctccaggccg aacacctggt acgcgacgac cgaggcgaca gtggactgga gcaccccggc
    18001 caggccgaac gcgatgccgt acccgaagag caggtcgagc ttgcccagcg gcgtggtgag
    18061 caggcgctcc agcgtgccgg tggtgcgctc gcggagcatg gcgatgctgg tcacgaggaa
    18121 catgatgatg aacggaaaga agcccagcat gatcagggcc acccggtcga acgtgctggg
    18181 cgcgccgggc ggggcgggct ggtcgacgta catgaagtag acgagcgtga gcagcaccga
    18241 cggcaccacc acgagcagcg ccacggtccg ccggtcgtgc cggagctggc gcaggatgcg
    18301 cccggtggtg gcggccagga tccgtccgtt catcgcgcct ctccctcggc gtcgcggatc
    18361 aggcgcagga acgcctcttc caggtcgtcg gtcccggtgg cggcgcggac cgcggccggg
    18421 gtgtcgtcgg cgaccagccg gccctcgcgg atcagcagca gtcggtcgca gcgggcggcc
    18481 tcgtccatca cgtggctgga caccagcagc gtggtgccgg cggcggccat ggcgtggaac
    18541 cgggcccaca ggtcggcccg cagcaccggg tcctggccga ccgtcggctc gtcgaggacg
    18601 accagctccg gctcgccgac cagcgcgcac gcgagcgagg cgcggctgcg ctggccgccg
    18661 gagagcgtgc cgacgagctg gtcggccgcc tttcccaggc cgacgtcggt gaccgcgcgg
    18721 tcggcctcgg cgcggccccg gccctggagc accgcgaagt agcgggcgtt ctcccgcacc
    18781 gtcaggtcgg cgtagacgct cggcgcctgg gtcaggtagc ccacccggcg gcgcaggtcg
    18841 gccgagccgg ccgggcggcc gagcacgtcg accgcgccgg agccgaccgt ctgcacgccg
    18901 accaccgcgc gcatcagcgt ggtcttgccg ctgccgctgg gcccgagcag cccggtcacc
    18961 gtgccccggg gcaccccgca ggtgatgccg tgcagcaccc gccgcccgcc ccggtcgacc
    19021 accagctcgc ggaccgacac cgcgtcgtcc atgctcgcct ccgtcaattc atcacccgat
    19081 gaactcaacg ctagatgaat tccgtcggcg aggcaacgag ggacttgact tcgagtgggc
    19141 tcgaactgga agcctggagg gcgtggacat cagcacgcgg gagacgagcc tcaccgtggg
    19201 tgaggcggcg gaacgggtcg gcctgaccac ctacacgctg cgctggtacg agcaggaggg
    19261 gctggtgggc cgcgtcggac gggactcctc cggccgccgg cgctacaccg agtccgacgt
    19321 caactggctg ttcctgctca cccggctgcg gcgcaccggg atgccggtgc gcgacatgcg
    19381 ccgctacgcc gagctggccc ggcacggcga cagcacgctc ggcgcgcggc gggcgctgtt
    19441 cgaggcgcac cgcgcccggg tgctggcccg gatggccgag ctggaggagg acctgaaggt
    19501 tctcgaacac aagatcgacg cgtaccggcg ggcggaggag gagtcgggct gaacacccgg
    19561 cggcggacag ggagtccggc atcggaagat caggtttcgg caccatgagg cagtgggtcc
    19621 agctccgttg tccgacaccg ggttcctcga cctctgggcc gcccgcctgc ggcacgccgc
    19681 cgaccggccg gtcgtcggga tcatgctgcg gggcagccac gcccggcggg ccgccaccga
    19741 gcacagcgac gtggacgtgg acgtgctggt ggccgccgac gagccacgcg ccaccggcgg
    19801 gccccggccg gtcacgtccc gccgcggcac gccgtacgcg gcccggcggg cgtacctgac
    19861 cgagttcggc ggccgcctgg tgcacgtctc cgtggccgcc cgcgacgtcc gctcctgggt
    19921 acgccggctc ggccagcccg ccgactgggc gttcggcctc ccggtcaccg cgccggcccg
    19981 gctgctctgg gcggtgccgg aatggcggcg ccggatcgac ctgccggtgc tctgccagcc
    20041 cgccgacgag ccgcgcctgg aggagctgat cgccacgctg ggcaaggtcg ccgccgcgcg
    20101 cctggccggt gacccggtcg gggtccggct cgccgcggcc gacctggccc ggctctgccc
    20161 ctcggtgctg cggccggcca acccgtcggt gcgcgtggtg tcccgccggg ccgccctgac
    20221 cgccgcgctg gacctgccgg tcgccccgcc cggctaccgc gacgacatgc tcctctgcct
    20281 cgggctgcgc cccggcgacc cggccgaggt cggcgccgcc gccggacggc tggtcaccgg
    20341 catcctcccg ctggtgcgcc cgtacgcggc ggagatcgcc cggaccaccg ggaccgacct
    20401 ggccgaggcg ctcaccgacg gccgggcgga ccgctacctg cggcagctgg gccgggcgct
    20461 ggcgacggtg acgcccgcct cccgggacac gtcggcggta cccgggccgc gtgcgggaga
    20521 atggtcaacc gtgcccgccc ctgacgcgcc gctgaccggc gcccccagtc ccggcccggc
    20581 ccggccgtcc cggctcgacc cggccatcgc ggccaaactc cgccgcaccc cggacggcct
    20641 ggtcgccgcc gtggtccgcg cccacgacac gggcgaggtg ctgatggtcg cctggatgga
    20701 cgacgaggcg ctgcaccgca cgctcaccac cggccgggcc acctactggt cgcgcagccg
    20761 cggcgagtac tgggtcaagg gcgccacctc cggcaaccac cagtacgtgc gctcggtggc
    20821 cctggactgc gacggcgacg cgctgctggt cagcgtggag caggtcggcg cggcctgcca
    20881 caccgggcag cgcacctgct tcttcaccga cctgccggtc agctcaccgg aggagacccc
    20941 gtgaccgacg g
//
