LOCUS       NZ_CP011151            25239 bp    DNA     circular CON 28-JAN-2024
DEFINITION  Bacillus cereus strain CMCC P0021 chromosome, complete genome.
ACCESSION   NZ_CP011151
VERSION     NZ_CP011151.1
KEYWORDS    RefSeq.
SOURCE      Bacillus cereus
  ORGANISM  Bacillus cereus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5521782)
  AUTHORS   Wang,Y., Tian,W., Zhu,L., Wang,B., Wang,H. and Zeng,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2015) Institute for Biological Product Control,
            National Institutes for Food and Drug Control, No. 2, Tiantan Xili,
            Dongcheng District, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: RS_HGAP_Assembly v. V2
            Genome Coverage                   :: 35.03
            Sequencing Technology             :: Pacific Biosciences
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 08:42:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,142
            CDSs (total)                      :: 5,983
            Genes (coding)                    :: 5,793
            CDSs (with protein)               :: 5,793
            Genes (RNA)                       :: 159
            rRNAs                             :: 16, 16, 16 (5S, 16S, 23S)
            complete rRNAs                    :: 16, 16, 16 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 190
            CDSs (without protein)            :: 190
            Pseudo Genes (ambiguous residues) :: 0 of 190
            Pseudo Genes (frameshifted)       :: 77 of 190
            Pseudo Genes (incomplete)         :: 106 of 190
            Pseudo Genes (internal stop)      :: 68 of 190
            Pseudo Genes (multiple problems)  :: 50 of 190
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:21:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2565363
            Orig. end                         :: 2590602
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011151.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="7"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            295..1221
                     /gene="bla"
                     /locus_tag="WR47_RS12580"
                     /old_locus_tag="WR47_12920"
     CDS             295..1221
                     /EC_number="3.5.2.6"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="WR47_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12920"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_063549314.1"
                     /transl_table=11
                     /translation="MILKNKRMLKIGICVGILGLSITSLEAFTGGALQVEAKEKTGQVK
                     HKNQATHKEFSQLEKKFDARVGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKALRKMGDRVTMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEATYDNQLIAEATKVIVKALR"
     gene            1482..2324
                     /locus_tag="WR47_RS12585"
                     /old_locus_tag="WR47_12925"
     CDS             1482..2324
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="WR47_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12925"
                     /product="metallophosphoesterase"
                     /protein_id="WP_000727189.1"
                     /sec_met_domain="Metallophos_2 (E-value: 8.4e-08, bitscore:
                     30.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKIKSIDPDIIAITGDLIDSKSYDAEVSMQLIREI
                     VKKYPVYFVTGNHEQWSGKYNNLEKELKKYDVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     VTGNRDEGNIIIDEIKKAKIEMQPDKYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYVEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            2540..2791
                     /locus_tag="WR47_RS12590"
                     /old_locus_tag="WR47_12930"
     CDS             2540..2791
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="WR47_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12930"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            2980..3705
                     /locus_tag="WR47_RS12595"
                     /old_locus_tag="WR47_12935"
     CDS             2980..3705
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="WR47_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12935"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001187075.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKSKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVSS"
     gene            3702..4721
                     /locus_tag="WR47_RS12600"
                     /old_locus_tag="WR47_12940"
     CDS             3702..4721
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="WR47_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12940"
                     /product="ABC transporter permease"
                     /protein_id="WP_006928521.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKVMKNQEASIYEYSKENAISELEKQKVDAILRIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPMESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            4746..5399
                     /locus_tag="WR47_RS12605"
                     /old_locus_tag="WR47_12945"
     CDS             4746..5399
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168191.1"
                     /locus_tag="WR47_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12945"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_063547336.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKRNVRQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYERLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRF"
     gene            complement(5521..5820)
                     /locus_tag="WR47_RS12610"
                     /old_locus_tag="WR47_12950"
     CDS             complement(5521..5820)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="WR47_RS12610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12950"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_000728157.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLALSIMFLGTSTQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            6054..7022
                     /locus_tag="WR47_RS12615"
                     /old_locus_tag="WR47_12955"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="WR47_RS12615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12955"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_044306560.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQTIPDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGSGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHSKNIKDLVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="WR47_RS12620"
                     /old_locus_tag="WR47_12960"
     CDS             7239..8384
                     /EC_number="1.3.99.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="WR47_RS12620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12960"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397279.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-39, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.6e-26, bitscore:
                     88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 7.5e-57, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="WR47_RS12625"
                     /old_locus_tag="WR47_12965"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="WR47_RS12625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12965"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_063547337.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.7e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.6e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 3e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.8e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAILK
                     LHDALEELKVEGIKTNTPMLLQVLEDDVFKSGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="WR47_RS12630"
                     /old_locus_tag="WR47_12970"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="WR47_RS12630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12970"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="WR47_RS12635"
                     /old_locus_tag="WR47_12975"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="WR47_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12975"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_063547338.1"
                     /sec_met_domain="HMGL-like (E-value: 1.9e-48, bitscore:
                     163.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALAVIEDITKQATFEGKKVRGYVSTVFGCPYEGDISVTAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGIKTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="WR47_RS12640"
                     /old_locus_tag="WR47_12980"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 5.8e-74. Score:
                     240.4. Matches aSDomain: nrpspksdomains_WR47_RS12640_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="WR47_RS12640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12980"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_063547339.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLDELQTILTQI
                     SEDSNVRVVILTGAGEKAFCAGADLKERANMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAECTSLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKKAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRTPTYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_WR47_RS12640_ECH.1"
                     /evalue="5.80E-74"
                     /label="WR47_RS12640_ECH.1"
                     /locus_tag="WR47_RS12640"
                     /protein_end="254"
                     /protein_start="14"
                     /score="240.4"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLDELQTILTQISEDSNVRVVILTGA
                     GEKAFCAGADLKERANMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAECTSLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKKAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="WR47_RS12645"
                     /old_locus_tag="WR47_12985"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389703.2"
                     /locus_tag="WR47_RS12645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12985"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886755.1"
                     /transl_table=11
                     /translation="MLDQKQQSNTFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="WR47_RS12650"
                     /old_locus_tag="WR47_12990"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 3.9e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_WR47_RS12650_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="WR47_RS12650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_12990"
                     /product="AMP-binding protein"
                     /protein_id="WP_000806506.1"
                     /sec_met_domain="AMP-binding (E-value: 7.3e-88, bitscore:
                     293.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYSWMKSLGYEDYETFYNKSIEETAWLW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFAVLREGVIFTEDLKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13596..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_WR47_RS12650_AMP-binding.1"
                     /evalue="3.90E-82"
                     /label="WR47_RS12650_AMP-binding.1"
                     /locus_tag="WR47_RS12650"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_WR47_RS12650_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="WR47_RS12650"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_WR47_RS12650_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="WR47_RS12650"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15561..15893)
                     /locus_tag="WR47_RS12655"
                     /old_locus_tag="WR47_12995"
     CDS             complement(15561..15893)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="WR47_RS12655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="WR47_12995"
                     /product="hypothetical protein"
                     /protein_id="WP_063547340.1"
                     /transl_table=11
                     /translation="MIAGVLRKSIVVMIGGNLKKSIIVMMIGVLRKSIVMMIGGNLKKS
                     VIVMMIGVLNEISVVVNVSLFVAIVKEKIGNIFNVNVKKKICLLESIGLFRKVDPSPTS
                     LLSLNF"
     gene            16491..16847
                     /locus_tag="WR47_RS12660"
                     /old_locus_tag="WR47_13000"
     CDS             16491..16847
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="WR47_RS12660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13000"
                     /product="hypothetical protein"
                     /protein_id="WP_063245759.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRIYVGTVSSVSCDVVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     misc_feature    16862..16877
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            16953..17486
                     /locus_tag="WR47_RS12665"
                     /old_locus_tag="WR47_13005"
     CDS             16953..17486
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="WR47_RS12665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13005"
                     /product="GNAT family protein"
                     /protein_id="WP_000990089.1"
                     /transl_table=11
                     /translation="MMYERSMEVIKLKTFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEETSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNISAISCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     gene            complement(17756..18364)
                     /locus_tag="WR47_RS12670"
                     /old_locus_tag="WR47_13010"
     CDS             complement(17756..18364)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="WR47_RS12670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13010"
                     /product="hypothetical protein"
                     /protein_id="WP_063547341.1"
                     /transl_table=11
                     /translation="MTEIKVGLTQFLDFTLKGSTAKTTFIKNLRSQPEYQPAFDYWKQL
                     RETVIKFHQNRLPFEYFETLVQTVDQKKKQNYIDVIKQYKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     misc_feature    18515..18531
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.51"
                     /tool="antismash"
     misc_feature    18971..18987
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.65"
                     /tool="antismash"
     gene            complement(19078..19215)
                     /locus_tag="WR47_RS30805"
                     /old_locus_tag="WR47_13015"
     CDS             complement(19078..19215)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="WR47_RS30805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13015"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     misc_feature    complement(19368..19377)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            <19381..19491
                     /locus_tag="WR47_RS30810"
                     /pseudo=""
     CDS             <19381..19491
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="WR47_RS30810"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLRHVIVHEIHHIGQLSIWARELNLQPVSANLIGRG"
     gene            complement(19553..20569)
                     /locus_tag="WR47_RS12675"
                     /old_locus_tag="WR47_13020"
     CDS             complement(19553..20569)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="WR47_RS12675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13020"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_063547342.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSATLSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGTEDNFTILMNKKAKELQLLQPSPFLNS
                     TGINHDTNKQSTTTAIDAAKLAARLVKDFPDVLNITKLTSYQFTFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLGDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(20745..21902)
                     /locus_tag="WR47_RS12680"
                     /old_locus_tag="WR47_13025"
     CDS             complement(20745..21902)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129473.1"
                     /locus_tag="WR47_RS12680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13025"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243312.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHEKKLYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKC"
     gene            complement(21892..22587)
                     /locus_tag="WR47_RS12685"
                     /old_locus_tag="WR47_13030"
     CDS             complement(21892..22587)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="WR47_RS12685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13030"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038809.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            22780..23388
                     /gene="yqeK"
                     /locus_tag="WR47_RS12690"
                     /old_locus_tag="WR47_13035"
     CDS             22780..23388
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016124593.1"
                     /locus_tag="WR47_RS12690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13035"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_063547343.1"
                     /transl_table=11
                     /translation="MLCNDIYLFTPTGKIDNDIKAFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIVETERKIPMIIHQKLSRVI
                     AKEIFKVEDEEILNAICCHTTLRKHATKMDLVLFVADKIEWDQNGTPPYLIEIKKGLEK
                     SLEKAAFVYISYLWERKDTLKVIHPWLEEAYWDLKGILQ"
     gene            23402..24076
                     /locus_tag="WR47_RS12695"
                     /old_locus_tag="WR47_13040"
     CDS             23402..24076
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="WR47_RS12695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13040"
                     /product="DUF3885 domain-containing protein"
                     /protein_id="WP_043924663.1"
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLGPYLYSQWGNHLHFDFGKDKYQIVEGTND
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENIKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADLYCTYHFSLKCLAEDIKYELLIQAANHEDFSALYPRFGRK
                     KEISYPDVFLINATKDIVMFMCDDRGCEVIAKNKEIIRDLYKKYKEWIPDYERESIDNL
                     FK"
     gene            24073..24810
                     /gene="mtnN"
                     /locus_tag="WR47_RS12700"
                     /old_locus_tag="WR47_13045"
     CDS             24073..24810
                     /EC_number="3.2.2.16"
                     /EC_number="3.2.2.9"
                     /GO_function="GO:0008782 - adenosylhomocysteine
                     nucleosidase activity [Evidence IEA]"
                     /GO_function="GO:0008930 - methylthioadenosine nucleosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019509 - L-methionine salvage from
                     methylthioadenosine [Evidence IEA]"
                     /codon_start=1
                     /gene="mtnN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="WR47_RS12700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_13045"
                     /product="5'-methylthioadenosine/S-adenosylhomocysteine
                     nucleosidase"
                     /protein_id="WP_000151939.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRSYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
ORIGIN
        1 tagatgtata ctttgattta aaacagcaac gtatacatgg tgaagctact agtacaggta
       61 gttctaagca aaattagagt acttttctca gggaaagaac ctgttcatat aaagccattt
      121 ataagtaaaa aaatgaaata tgaaatagga gatagaggcg tcgtagctac tatctcttat
      181 tttgttaata actctcatac tagctataat ttttttagtt tatggaacaa atttggttcg
      241 gtgattgtct attatgtgta cgtataaaaa ggtgctaaaa atttggaagg aatgatgatt
      301 ttgaaaaata agaggatgct aaaaatagga atatgcgttg gtatattagg tttaagtatt
      361 acaagcctag aagcttttac aggaggggca ctgcaagttg aagcgaaaga aaagactgga
      421 caagtgaaac ataaaaatca ggcgacgcat aaagagttct ctcaacttga gaaaaaattt
      481 gatgctcgag taggtgtata tgcgattgat actggtacaa atcaaacaat ttcttatcga
      541 tctaacgaaa gatttgcctt cgcatcaacc tacaaggctt tagcagcagg agtattacta
      601 cagcaaaact caattgatac attaaatgaa gtaatcacat ttacgaaaga agacttagtg
      661 gattattcac ctgttacaga gaaacatgta gatactggaa tgaaactagg agaaattgct
      721 gaggctgctg ttcgttcaag tgataatact gcagggaaca ttttatttaa taaaataggc
      781 ggacctaaag gatatgaaaa agcgcttaga aagatggggg atcgggttac tatgtctgat
      841 cgctttgaaa cagaattaaa cgaagctatt ccaggagaca ttcgtgacac tagtacagcg
      901 aaagcaattg ctacgaatct taaagctttt acggtcggaa atgcacttcc agctgaaaaa
      961 cgtaaaattc ttacagagtg gatgaaagga aatgctacag gggacaaact tattcgtgca
     1021 ggcgtaccaa ctgactgggt agttggagat aaatcaggtg ctggcagtta cgggacaaga
     1081 aatgatattg ctatcgtttg gcctccgaat agagcaccaa ttatcatcgc aattttatct
     1141 agtaaagatg agaaagaggc aacctatgat aatcaactca ttgcagaggc aactaaagtt
     1201 atagttaagg ctcttaggta atagtatttt agttttcgca tttttaacat gaaagtatta
     1261 aaagtataaa gttagaaaac gactcttttc gtgtgataag agtcgttttt gtattcttat
     1321 tattaaaaag gtaaaagtaa aaatataacg aatatatatg acatatctca tatgaaattt
     1381 catgtactgt attattttat taatttaaat aaatttcaag aaagtataat ataattcagt
     1441 tagcatatag aagtgtttga tgagaatgta aaggagaaaa tatgaaaaag aagattaata
     1501 gaattgtaat gattatttgt atattagtag gttttacaat ctttttatat ttacagaaca
     1561 atttaataag tataactgag gttaaaataa cctctagtaa aataccatcc tcttttaaag
     1621 ggtataaaat tctacaaatt tcagacttac acaataaaaa atttggcgat aatcaagatg
     1681 tgttaattca aaaaataaaa agtatagacc cagatattat tgcgattacg ggtgatttaa
     1741 ttgacagtaa atcatacgat gcagaagtta gtatgcaatt aatacgagaa attgtaaaga
     1801 aatatcctgt atattttgtg acaggaaacc atgaacaatg gtctggaaag tataacaatt
     1861 tagaaaaaga gttgaagaaa tatgatgtca atgttttaag gaatgaacat gtaggcattc
     1921 gaaagggtga gcaagaaata aacttgctag gtattgatga tccagagttt gttactggaa
     1981 accgtgatga aggaaatatt ataatagatg aaattaaaaa agcgaaaatt gaaatgcagc
     2041 cagataaata taatgtatta ttatcccatc ggcctgaatt tataaaggaa tatacgaatg
     2101 agaggttgga tttggtttta tcgggacatg ctcatggagg gcaagttaga ttgccattta
     2161 tcggaggatt agttgcgcca aatcaaggtg ttttacctaa atatacagcg ggtttatatg
     2221 tagaacaaaa tacatcaatg gtagtgagta gaggattagg aaatagtatc attccgcaaa
     2281 ggattttgaa taggccagaa attgtagtcg tgcagctaaa ttaagctgta cgattttttt
     2341 tatacaaaaa tgagtaaagg ggctttctgt attttgcagg agtaaacatt acaattttgt
     2401 taaaaatttt ctacgttaca taaagtaaca aaatttgacc ctcagtgttt gttatagtgt
     2461 aaataatcaa aaaacttaaa atttgtcgag tgaaaattgt gataagtaat tcatataaaa
     2521 aacttaaagg ggtgtacaca tgcataaaga atatgaaatt gaagaataca cggcgattga
     2581 ggaacaaatc cattattatt gtaaatgttt attagtaagt catcctgatc aaataataaa
     2641 gtatttagaa aaaaggttag aaaaatatgc agaaacatta caatatgcac atttatatcc
     2701 tgacacagtt attttaccgt tacagcaatt agttatcgaa tattctttag acgttgctag
     2761 aattcggaag tatatgaatt taaaaacgta aagtgaaatt tatagtttaa atgaaacaga
     2821 gtcgacttta ggaaatgaaa tgctaatgtc gactctgttt cattgtttaa tatcggtgat
     2881 tgaacataca tactaatcaa cgaagtttga catataatta agcaagagta aaataaaagt
     2941 gagtactcac tcatttttat tggaaaagga ggatgaaacg tgcaacaacc ttcaattatt
     3001 ttacggactg tatcaaaaag ttttggaaaa aaagaagtgt tacacaatct ttcattgcaa
     3061 gttgaaaaag cagagatttt tggttttgtt ggaccttctg gatcggggaa aacaacgctc
     3121 attaaaatga ttgcaggtat taatgaggca acgaaaggtg aagtgcttgt taataatact
     3181 aatatgccta atttaaatga aatgaaacga attggttata tggcccaggc ggatgcatta
     3241 tatgaagaat tgtcagcata tgaaaatgca gattttatag caacgatgta tggattaaag
     3301 ggaaaaagta aaaagacaag aattgcagag gtttttgaac ttgtacaatt gtcacagtat
     3361 atgaaaaagc aagtacaaca attttcaggt ggaatgaaaa aacgcttatc attagcaata
     3421 gcactcctcc atgaaccaga aatattaatt ttagatgagc ctacagtggg gatagatccg
     3481 cttcttagaa aaacgatttg ggaaaaattt tatgatctta aaaagaaagg cacaacgatt
     3541 attgtaacga cgcacattat ggatgaagct gaattttgtg agcgtctagg gttaattaga
     3601 gaagggaaac tagttgcggt tggaacaact gaagaattga aaaaacgcgt gtcatctgga
     3661 cggattgaag atgtcttttt gttggaagag gtggtgtcat catgagagtt actggtgtaa
     3721 tcattcgtat tattcgccaa ttttttcgag ataagcgttc gttagcgatg atgtttgggg
     3781 caccaatgtt attactttgg ctattatcgc tagtgtttac acaaaaagac tatataccgc
     3841 aaattgctgt tgttgatatg cccgctcaaa tagtaaaagt gatgaaaaat caagaagcgt
     3901 caatttatga atacagtaaa gaaaacgcga tttctgagtt agaaaaacaa aaggtagatg
     3961 caatacttcg aatagagaat ggaaaaatga aacttctgtt ggaaggtagt gattcgtcaa
     4021 aaaatcgtgc tgtacttcaa gtattgcaaa aaagcacaga gaagaatgat gtatcgatta
     4081 tgaaacctga agtaaattat ttacatggct ctaaagactt tacgatgttt gatgggcttg
     4141 gtcctgtatt aattggtttc tttacatttt tctttgtatt tatattatca ggtgtatctt
     4201 tcgtaagaga acgtttaagt ggtacgctag aaaggttatt atccacccca gtaagaagat
     4261 gggaaatagt cgcaggttat attattggtt ttggaatctt tgcctttata caatccatta
     4321 ttatcgtaag tttttccgtt tatattttag atttatacgt agctggctcc atatggctaa
     4381 cgttacttat tacatgtatg ctctctttaa ctgcactaac attaggtacg tttttatcgg
     4441 catacgcaaa taatgaattt caaatgattc aatttatacc gcttgttatt gtgccacaaa
     4501 tcttcttttc tggattgttt ccaatggaat ctatgaataa gtggctacaa atgttaggga
     4561 aagtatttcc actcacatac ggcgctgacg caatgagaca agtgatgatt cggaatcaag
     4621 ggtttacaga gattgcatta gatcttactg tattattact tttttcacta ttatttgcag
     4681 taggaaatgt atttgcttta aagaaacatc gcaaaatata ataatgacaa aaaggagctt
     4741 tataaatgca gaaggattgg ctggaggaat taatagctgc aactaatacg gataaaagaa
     4801 atgtacgtca aatgcgaata ttagaggcgg ctgttgatat gtttggagaa aaaggatacg
     4861 cttcaacttc aacaagtgaa attgcaaaac gggctggtgt agcggaagga acaatcttcc
     4921 gctactataa gacgaaaaaa gatttattac tagcggtcgt aatgccaact ttaactaagt
     4981 tcgctgcacc atttttcgta caaacctttg caaaagaaat atttaaatcg gagtatgaat
     5041 catatgaaag acttttaagg gttgtaattc ataataggtt taaatttgct caaaaacact
     5101 ttcctatgat aaaaatatta attcaagagg tgccattcca accagaactg aaaaatgaaa
     5161 tacagcaatt agtagaaaca gaactgtttt cacatttcaa aaagttgatt gtgaaatttc
     5221 aagaagaagg ggaaattatt gagataccac catcttccgt actacgtctt actttatcag
     5281 ctgtattagg tttattatta acacgatttt tattattgcc tgaagaaaaa tggaatgatg
     5341 aagcggaaat tgaaaatacg attcaattta tattgtatgg attaactcca cgattttaat
     5401 cgttgaagtg tgaatgacat acattacttt taagtaaaaa taaatcgcct ttaaaaaggc
     5461 gatttatttt cattatatat ttttgataaa taagtacttg tttactaaaa acattctaaa
     5521 tcagcgtgtt tctttgtctc ttcttctaag acctaataat cctgctagtc ctaataaacc
     5581 aagccaagcc caattattat ttttatcacg attatcattt aaatcatttg ttgtatttac
     5641 atttcgagtt cttacatcat tattaactct gtctaagtta ttgtcattta ctcgagttga
     5701 aatatcagtg ttattaactc tattcatatt atttccatcg tattcagctt gcgtagatgt
     5761 acctaaaaac ataatagata gtgctaaaac acttaaaata gatgataatt tctttttcat
     5821 aacaatccct cctttcttaa tcattaattt ctccgaagca agtgtgtatt attcatttca
     5881 caatatctaa accctcatta ataaggcgca catttataga aaatagagtt gaatgattgt
     5941 taatatatca ttggatatat atttctcata aaaataaatg aatcaaactt tgcttaaaat
     6001 gttaatctta gtacaattta tattatacgg gctagcacta aggaggtaat aagatgcgac
     6061 aatttgcaaa accaacaatc gtcgtaagta aatgtttaga atttgatgct tgtcgttata
     6121 atggagagat gattccagat gtaacaatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag attggattgg ggactcctcg tgaaacgata cgaattgtag
     6241 aagaaaatgg tgagaataga cttgtgcaac cgtcgacacg agaagatgta actgaaaaaa
     6301 tggagcagtt ttcaaatgac tttttacaaa cgataccgga tgtggatggt tttattttaa
     6361 agaatcgttc accaagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 cgccagcaaa gggaaaagga tcgggcttat ttggcggagc agtagtaaaa aaattttcgc
     6481 atcttcctat tgaagaggaa ggcagattgt cgaattttat tattagagag catttcttta
     6541 caaggctatt tacaatcgca tattacaaaa tgattaaaca tagtaaaaat ataaaagacc
     6601 ttgtatcgtt tcagtcggac aataaatatt tatttatggc atataatcag gtgaaacaaa
     6661 aggaattagg gcgtataatt gcaaatcaaa aaaatgaaaa gattgaagtg gtatttgaaa
     6721 actatgagaa gactttatat gaattattta tgcgtgcgcc ccgttataca tcgaatgtaa
     6781 atgtatgcga gcacattttt ggatatttta aaacaaagtt aaaaaaacaa gaaaaagatc
     6841 attttataga actgttacaa aagtatgcag aaaagaaaat accacttagt agtttactta
     6901 caattttaaa atcatgggct attcgatttg atgaaaagta tttattaaga caaacatatt
     6961 tcgaaccata ccctgaagca ttagtagaaa tttctgattc cggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacacaaaa cctcctatgt tgttgtagaa caatgtagga
     7081 ttttttttgt gcattagtac agaatctgtt ttaaaattaa gttatgacag aattgtagca
     7141 attgtctaac taatattctt gtcttttaag ttgttatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taagggatgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcagagtttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattatt aggcatccca ttcccagaag agtatggagg ttcaggtggc gatacggtat
     7441 cgtatgcgtt agcagttgaa gaaattggtc gcgcttgtgg tggcaccggt ttaagctatg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 aaaagtattt agttccaatg gcgtcaggta aaacattagg tgccttcgga ttaacggagc
     7621 cgaatgctgg atcagatgca ggtggtactc aaacgaaagc ggtattagat ggtgatgagt
     7681 atgtaatcag tggtgagaag tgttggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctgt caacggtatt gaagagaatg gtagaaaacg tatttctgca tttatcgtgc
     7801 ctactacgag tgaaggatta acgatttcaa gtccttacga taagatgggt gttcgcgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg ttcgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggctttaaa caatttttat atacacttga tggagggcgt atttcaatcg
     7981 ctgcattggc agttggtatt gcgcaatcag cctttgaacg tgcattacaa tatgcgaaag
     8041 aacgtcaaca atttggaaag tcaatctcta atttccaagc gattcaattt aaattagctg
     8101 atatggcgac tgaagtagag ctagcacgca atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa gcctttcggc aaagaagcgg caatggcaaa actatttgca tcggaagcag
     8221 caagccgtat tgcgaatcaa gcagtacaga ttcatggtgg atatggttat atgcgtgaat
     8281 atgaagttga acgacatatt cgtgatgcga aactattaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gctagacatt taggatgtag ataaaaggga ggaatcacta
     8401 tgtttcaaaa aatattaatt gcgaatcgcg gggaaattgc tgttcgtatt atgaaaactt
     8461 gtcaaaaact tggcatacgc actgttgcta tttattctga agcagatgaa aatgcccttc
     8521 atgtgaagat ggcaaatgaa gcttacttag taggtggacc gcgtgttcaa gaaagttatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgcagaagcg attcatccgg
     8641 gttatggttt attatcagag aatccgtctt ttccggttcg ttgcaaagaa gaaggaatcg
     8701 tatttatcgg tccttcagaa gaaatcatta cgaagatggg aagtaaaatc gaatcacgta
     8761 tcgcaatgca agcagcagat gtcccagtag tcccaggtat tactacaaat attgaaactg
     8821 ctgaagaagc aattgaaatt gcaaaacaaa ttggttatcc cttaatgctt aaggcatccg
     8881 caggcggcgg aggcattggt atgcagttga tggaaactga gcaaacgctc accaaagcgt
     8941 ttgaaagtaa taaaacaaga gcgcaaaact tctttggtaa cggagaaatg tatttagagc
     9001 gatatatagc agatgcgcat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cagtgtattt atgggagcgt gaatgttcgg tacagcgccg aaatcaaaaa gtaatcgaag
     9121 aagcaccttc accattttta gatgaaggta cacgaaaggc gatgggagaa gttgctgtac
     9181 aagctgccaa agcacttggc tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 agaagaactt ctatttctta gagatgaata cgagattaca agtagagcat ccagtgacag
     9301 aagaaattac gggattagac cttgtagaac agcaactcct tatcgcaagt ggagagaaac
     9361 tatcatttac tcaggatgat gtaaaacgta gtggtcatgc cattgaagct cgtatttatg
     9421 cagaggatcc gaaaacattc ttcccatcac ctgggaaaat tacagattta acattaccgt
     9481 caaatgtacg gattgatcac ttcttagaaa atcatgtaac gattacacct ttctatgatc
     9541 caatgattgc aaaagttatt gcacatggcg agactcgtga ggaagcaatt ttgaaattac
     9601 atgatgctct agaagaatta aaagtagaag gtattaaaac gaacacacca atgctactgc
     9661 aagttttaga agatgatgtg tttaaaagtg gtatttatac aacgggtttt gtaacgaaac
     9721 aactcgttaa gaaataagat ttaacaatat taagggggaa aaaatgatga cgaaagtata
     9781 cgcatcgatg gcaggaaacg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tagaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agctggcacg gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtaggac cacgtgatgg cttacagaac gaaaaaaaaa ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagca ggattgtcgt atgttgaagt
    10141 ttcctcattc gttcacccaa aatgggtccc agcattagcg gatgcaaatg atgtgttttc
    10201 tgagctgaaa agggatccta atgttacata tgctgcgctt gttccaaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatcaat taaagaagca ttagctgtaa tagaagatat
    10381 aacaaagcag gcaacatttg aaggtaaaaa agtaagaggc tatgtttcaa ctgtatttgg
    10441 atgtccttat gaaggggata taagtgtcac agcagttgac gaattatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctcttgg ggatacaatc ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaagtatgat gcttcgcagt ttgccatgca
    10621 ttttcataat acgtatggaa tggctctagc gaatgtagtt aaatcattag aatacggtat
    10681 taaaacgttt gatagttctt gtggtggact cgggggctgc ccttatgcac caggagcatc
    10741 aggtaatgtt gctactgatg acctagtaca tatgctccat aagttaggag tccaaacgaa
    10801 tattgatgaa gagaagttat tgagagcaag tcaatttatt caaagtaaat taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaacatttca gttgattatg taacacctca cgttgtaaag atttcgttat
    10981 atcgtgaaag acaagcaaac tcattatctt tagcattatt agatgaatta caaactatat
    11041 taactcaaat aagtgaagat tcaaacgtgc gtgtagttat tttgactggt gctggtgaaa
    11101 aagcattttg tgctggtgca gatttaaaag agcgtgccaa tatgaatgaa gaacaagttc
    11161 gccatgctgt tagtatgatt cgcactacta tggagatggt tgaacaatta ccacagccag
    11221 ttattgctgc tataaatgga atcgcacttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgctgctgaa tgtacaagtc ttggtcttac tgaaacgaca cttgcaatta
    11341 taccaggagc aggtggtaca cagcgcttac cgagattaat tggagttggt agagcgaaag
    11401 aattaattta tacaggtaga cgtatttcag cgcaagaagc aaaagaatat ggtttagtag
    11461 aatttgttgt accagctaat ttacttgaag agaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg acctattgct gttcgattag caaaaaaagc gatttcaaac ggtattcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagatagact agaaggatta caagcattca aggaaaaacg cacaccaacg tataaggggg
    11701 agtaaatatg ttagatcaaa aacaacaatc aaatacattt gaagaacgag ttgaaacgat
    11761 taaacaaggc ggcgcaccaa aatatcatga acaaaataaa gcaaaaggaa aattatttgt
    11821 tcgagatcgt ttagcgcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 taactgtgaa caaacaggct tacctgcgga cggcgttgta acggcaacgg gtaaaataca
    11941 tggtcgtact gcgtgtgtaa tggccaatga ttctactgta aaagctggat cgtggggatc
    12001 acgcacagtt gaaaagattt tacgtattca agaaacagct gaaaaactac gtgttccgtt
    12061 attttattta gtcgactctg ctggagcacg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgtggt gcagggagaa tcttctataa tcaagtgaaa ttatcaggta aagttcctca
    12181 agtatgctta ttatttggac cttctgcagc tggtggtgcc tatattccag ccttttgcga
    12241 cgttgtaatg atggtagaag gaaatgcatc tatgtattta ggatctcctc gtatggctga
    12301 gatggttatc ggtgagaagg taactttaga agaaatgggc ggagctcgta tgcattgctc
    12361 tgtatcagga tgcggagatg ttttatgtaa gacagaagaa gatgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaataacta cttagaaaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaatagagt tattgatgaa ggttcattct atgaagtaaa
    12601 aaaattattt gctcaagagc taattacagg cttagcacgt attgatggta agccagttgg
    12661 tattattgca aatcagccgc gtatgaaggg cggcgtatta ttccatgatt cagctgataa
    12721 agctgctaag tttattaatt tatgcgacgc atatcatatt ccattattat tccttgcgga
    12781 tgtaccagga tttatgatcg gtacaaaagt agagcgtgct ggtattattc gccacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaag atttctatcg ttgttcgtaa
    12901 agcatatggt gctggtttat atgcgatggc aggtccagca tttgaaccag attgctgcct
    12961 ggcattaccg acagcctcta ttgcggtaat gggtccagaa gctgcggtca atgctgtata
    13021 tgcaaataaa attgcagctt taccagaaga agagcgtgct agctttattg ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatatata ccacttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaagga cgtttcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gttaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtacaaggaa aaaacacgtt tatatagttg gatgaaatca ttgggatatg
    13381 aagactatga aactttttat aataaatcta ttgaagaaac agcttggctt tggggagagg
    13441 cagaaaaagc agttggctat caatggatga aaccttatac agaggtgtta gatttagaaa
    13501 atggtacacc gtttgcacag tggtataatg gcggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gcttgcggat gaagagacaa gaatacagcc agcacttcag tacgaaggag
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga taactgggta agccgtgttg
    13681 ccaatggttt gaaacacgcg ggtattgaaa aaggtgaccg tgtaacaatt tatatgccga
    13741 tgattccaga aacagttgtt gcgatgctag ctgtaatgaa aattggagca attatttcac
    13801 caatattctc aggctttgcg tctgatgcag ttatgacacg tgtgcaagcg gcgggttcaa
    13861 aaatgattat tactgcagat ggattttcac gccgcggtaa aattgtttct ttaaaagatg
    13921 aagtagataa agcttgtgaa cattgcccaa ctgttgaaaa agttgttatc gttcgtcatg
    13981 caggaaatga ttttacacca cataactatg acttttcgtg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgag gaaatgcaaa gtgatgatcc attaatgctc atttatacat
    14101 caggaacgac tggtaagccg aaaggaacag tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ttggatgatg gggccatttt tattattcgg ttcactcatt aatggagcaa
    14281 cgatggttat gtacgaaggt gttccagact tcccagaagc agaccggtta tgggagacag
    14341 ttgataaata tgaaattact catctaggta tttcgccaac gttaatccga gcattaatgg
    14401 caaaaggtga tgagtatgtc aataaacatt ctttaaagag tttggaagta ttcgcatcaa
    14461 caggagaacc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggtaaaggaa
    14521 atgttccaat ctgtaactac tcaggtggaa ctgaaatctc tggtgggatt ttcggtaatg
    14581 ttcttattaa accaatcgca ccaattagtt ttaacgcatc tttaccagga atggcagctg
    14641 tcgtactgga tgatcaaggt aaaccaattc gagatgaagt cggagaatta tgcttagaga
    14701 aaccttgggt aggtatgacg aaaagcttct gggaagatga tgaacgttac gtgaacacat
    14761 attggtcacg ttttgaaaat aaatgggtcc acggtgactg ggtcatttac gatggtgaac
    14821 aatatatcat cacagggcgt tcagacgata cgttaaatat tgcaggtaaa cgtattggac
    14881 ctgctgaata tgaatctatt cttgtgaaac ataacgatgt aatcgaagct gctgcaattg
    14941 gtgtacctga cgaagtgaaa ggtgaagttt gtcattgctt tgctgtatta cgagaagggg
    15001 taatatttac agaagattta aagaaagaat taatgagttt agtaaactca catattggca
    15061 aagcgttgtg tcctaaagac atccacgttg tagaggattt accgaaaaca cgtaattcta
    15121 aagtaatgcg ccgtgttatt aaagcagctt atttaggaaa agaattaggt gatttgtcgt
    15181 cacttgtaaa tcctgaagta gtaccgttta ttcaggggtt acagtctagt aaattataaa
    15241 attagaaagg agctctatat aaacagagct ccttttttat gttaataaaa agaaaaaaag
    15301 tgaatttgat gaagaagaaa aattctacta ttggtgttaa gtatgttttt tagttttaat
    15361 caaaatacga tattatggaa tgtctattca atggagaaat actaatttac aacaacaagg
    15421 tgatgacaaa gcgcgactac ttatatgccg gtttaaacct ttacgtattc attgataaaa
    15481 agctgactat actcagtcag ctttttatat attacatcct agtatttatc tcgctatttg
    15541 ccgggcagta atgcccccac ctaaaaattc agcgaaagca aggaagtagg tgagggatca
    15601 actttccgga aaagcccgat tgattccaaa agacatattt ttttctttac gttgacatta
    15661 aaaatattac caattttttc ttttacaatg gcaacaaata aagaaacatt tacaacgaca
    15721 cttatttcgt ttaaaactcc aatcatcatc acgatgacac ttttcttcag atttccacca
    15781 atcatcatta caatgctttt tctgagaact ccaatcatca tcacaatgat gcttttcttt
    15841 agatttccac caatcatcac aacaatgctt tttctgagaa ctccagcaat catttttcca
    15901 agacattcat ttctacctcc tttcaatagt gttcatatta ttctatgttt taataaaaaa
    15961 aatggcttgt ttattaacct actattttat ctttatatga tagagtgttt tctactcgat
    16021 atagagttca tacaaactat gctaattttt aagagatagt ggagagaact actactagtt
    16081 atggtgtttt ccaataaaca tttgttgaag aaagcgttct gattacatat aatatcttat
    16141 tttcgagtac gcttttttaa atgtatattt cacaatgaaa aatgggaaat ccacaaataa
    16201 agtctatgta tatgtgagtt aatgggaaaa tctagtgtgt ttttaagggg catcttatta
    16261 aaagaaaaag atttgtttta gaaagtggtg tctaaacatt aaatggagta ggactaaatt
    16321 cacggccgct cattaaacaa gattttaatt aggagaagtc tgtttttata atgaataatg
    16381 aaaagaaggt ttggtacaat tgtttgtttt tttcttttta tgtgtttgcc tcgtaccctt
    16441 ttaagctagt ggacatactt tactaataga aaggattagg gggtgaggta ttgggttctc
    16501 gatttaataa ttgtaaaaag aagtgtacat gtaaacaaga tgattgttgg gaagtattcg
    16561 aagagtgtaa aaaagaacag catgagaaat gtgataattc ttgtgtacaa ggaattagag
    16621 atgaacttaa gaaattaatt aatcgaacag ttcaaattaa tacagaggga cgtatttatg
    16681 taggtactgt ttcgtctgta agttgtgatg tagttaggct tgcggctatt cctggatcgg
    16741 ttggagtaat tatttccatt tgtaaaattg aagcaatttt cccacctgtt acaacggtta
    16801 ctgctgactt tgattttaat ggtattgatg tagcaaacaa agcataatta tgctgctttt
    16861 ttgtaaagcc attcacatga atggctttat tttaatttca tataaaagga gaatatattc
    16921 tttatataga aataagtttg aggttataaa gtatgatgta cgaaaggagc atggaagtga
    16981 ttaaactaaa aacctttaaa aaatctgatt ttaaacaatt aataaattgg attaattctg
    17041 aagaatttct aatacaatgg tcaggaaatg cattcacatt ccctttagac gaacagcaat
    17101 tagagaagta tatagaaagt gcaaatacac tcgctttcaa agtggtagat gaagagactt
    17161 cagacgttat tggtcatatt tcgcttgggc aaatagataa tattaataag tccgctagaa
    17221 ttggaaaagt attagttggt aatacgaaga tgagaggacg ttctatagga aaacatatga
    17281 tgaaagcagt acttcatatt gcttttgacg aattaaaact acatagagta actcttggtg
    17341 tgtatgattt taatatatcg gccatttcat gttacgaaaa aatagggttt gtaaaagaag
    17401 gcttattaag agagtcaaaa agagtaggag aaacgtattg gaatttatgg gaaatgagta
    17461 tgttagaata tgaatggaag aagtagcaac aatagtaatt tataattata ttatgttaac
    17521 aaaagggctt ggtgggtata gtggataata aaacaaaaat aatctcaatt gcagctgttt
    17581 cgggggagag ctagtatgtt aaaactgaca aagaaaccat ttttgaaaaa ggcccacctg
    17641 cattgtttct gaggaataag agggtgagcc ctaattaaac gaaactgaat gaatctgtaa
    17701 aaattgtaac taaagtatgc atcaacaagg tattaaaagg gatgaatagt aacctttata
    17761 gattattcca tatatagcaa aactggttag cttctgattt aagcgctact aaatgattat
    17821 tattaataga gttattcgta tacattctgt tcttttggat gttaagtacc gtataattca
    17881 catcgtttcg ttcatttgaa aatgttgatt catttaatag tgtaagtgtc gagttaatgt
    17941 tgtacttatc aattcgctct ttttttcctt tgaaaaacag tttgataaga tgtggctcat
    18001 tattaatgaa taagccaagt tcaggtgatg aacggacgat taaatcatct gatttccaat
    18061 gtgatttacc tggatcaaac caagagatgt ctttattttt aatgaatttt ttgtattgct
    18121 ttatgacatc aatgtagttt tgtttttttt tctgatcaac cgtttgtact aatgtttcga
    18181 aatattcaaa aggtagtctg ttttgatgaa atttaataac agtttctcgt aattgtttcc
    18241 agtaatcaaa agctggttga tattcaggtt gggatcttag attttttata aaggttgttt
    18301 tagctgtact acctttcagt gtgaagtcta aaaattgtgt aagccctact ttaatttctg
    18361 tcatattata tccccttcca aacattattc atttaataat agacgaaaaa tccgacattt
    18421 ttaaagaaat gagctagatg ctagaaaatc caatatccat gcacaataga tacgggaaag
    18481 ccaatccgta agtataaatg atggaccatt caattgaaga taaattaggt aataggattt
    18541 taccaggtga taggttatta atataatcag atagtgagct gattttaaaa gataacaata
    18601 tagattattt agcttggatt tgagaaaaaa agtacatggg aataaagagg gatataggga
    18661 aatgggccct catcaaaaaa tataagttgg tatcagtata ccgtagagaa tgagtgtata
    18721 gaacatacaa gtaaaagtat tggcaagcat acttaaaata agccgtataa aaagttaatc
    18781 attgtgtgct ttgataatat agcgtcagcg aaataaatag tgtgaaggag agctatctta
    18841 acaagtgttt catgtaacgt tcatatactt taattttatt attaatcaaa cttgaatatt
    18901 atagaaacgg ataatgaggt atgggtggtg ctctttttta ttgaataaaa tgggttgatt
    18961 tttcggattt tcattacaat ataacaaata aaatttaaat tttatttgtt gttaagaaaa
    19021 ggtgagaaga aaataaaaaa agagggctaa tgccctcttt tcttattaat ttggtaatta
    19081 atcacagatt ggtatcccaa gcactcttag agctaatgct acttgaaggg aaatctctaa
    19141 tctagcaatt tcaataccag ctactgaaag aactaaaaaa ggttgtccgt ttacaaatac
    19201 aacgcaacta tccatagtta aacctccttt ctagtaatct actatagtat atgaatagaa
    19261 ctttaaagtg taatagttaa attgttggat ttaatagaat taatagatta acccatttaa
    19321 actaaacaaa cgaatacaac gaaaggaaac agagatggat gtatgcctca aaaaacatag
    19381 gttttaagac atgtaatcgt acatgaaatc catcatattg gtcagctatc tatatgggcg
    19441 agggagttaa acttgcaacc agtttcagca aatttgattg gacgaggatg atagaattaa
    19501 aaaccgactt gcatctcaag cgcaagtcgg tttttatata taagaagatt tcttaattga
    19561 aatcttcgga ttttttctga cgtatatgta aaaacattaa ggtggtaatg attaagaaaa
    19621 tcattatagt ttgtataatt aagtttttaa actgaagcaa tattgtccaa gatgtaaggg
    19681 tgtctttaaa agcttggagt gcagagtacg aggaaggatc aaaaccatac tgtagcaact
    19741 tttttgtttc aataaatgag atgttttctt catctgcatc taatattact gaaattagtc
    19801 tagtatctcc tagttttgct gtactgacaa aactataatt accgttagtt gaaaaactag
    19861 tttgtaagcc atcaacacct tgaagtttaa tgttttcatt aagggaatat atcattttat
    19921 tcgtattgaa aacctgggaa tctttgaagg taaattggta agaggttagt ttcgtaatat
    19981 tcaatacatc tggaaaatct tttactaagc gtgcagctag tttagctgcg tctattgctg
    20041 ttgtagttga ttgtttattt gtatcatgat taattccagt agagtttaga aatggagatg
    20101 gttgtaataa ctgtagttct tttgcttttt tattcattaa tattgtaaag ttatcttcag
    20161 ttccagcaat gtgttctgct agagcgagtg cagaacgatt attccctgcc agtagcaatg
    20221 catgaagtaa atcacgaacc gttgttttat cattcgatgt tacttgtata gggcttgttt
    20281 ctactcggaa aacttcgtta cttatttgta cgaagtcatc taactgtatt tttctatcat
    20341 ttagttgttc caatacgata tattccgtca ttaatttaga taaagtagct gattgtactg
    20401 gggtttcttc atttttttta taaacaattt cacctgaatt agcatttatt aaaatagctg
    20461 atttagcttg aataatcgga ccatttacat aaagataaaa atataaaacg ataagtgcag
    20521 taatgaaaaa agataataat aaaatagcga atttttttaa gaattgcata agtgatcctc
    20581 ctattatgac agcaataata gtattgtaaa aaggaatgct taattaggaa gaaagaaaag
    20641 gtaaagaatt tctaaagaat tataaaggat tattaaattt agggaaataa tagaaaaagt
    20701 tcaatttctt atatgataag aaattgaact ttttatttgt aatattaaca tttgtatgga
    20761 agtagtttta cagtgaatgt tgttttttcg tcatcactat atacttcaat tgttccttta
    20821 tgcaactcga ctatactttt tgcaattgct aatccaagtc cagatccacc agtgtttgta
    20881 gagcgagatt tctcaacgcg gtaaaaacgt tcaaaaatat gaggtaaatc cgtactagga
    20941 ataggttgtc cgtaatttgt tatatcaatt gtaatcatat tattgctttc ataagcagta
    21001 aggtcaatat agcgaccttc gcttccataa gcgatagcgt ttataataag attttcaaac
    21061 acacgcacta atttgtcacc atcagctaat accataagct tttgagacgg gaaagaaggc
    21121 cgacattcta tattagcttc ttgaacctgt atgcggaatt gaacagttaa ttgtccaagt
    21181 aactctacaa tatcaatagg aacagaatac aagcttaatt ctttattttg aacacgtgta
    21241 tattcgaaca agtcattcat taatgcatta agacgagtta ctttatcgta aatgacttga
    21301 atatagtatc gcaattccac ttcatctcta taattatcat gatggattaa atttacgtat
    21361 ccaactatag aagtaagggg ggtgcgtaag tcatgtgata catttgtaat aagttcactt
    21421 tttgcttgtt ccgcttgtct ttcttcatca atggagactt ttaattgttc aacaatttca
    21481 ttgaccccga ttgctaattc ttctagataa ttatgattta caatagaaac tttatgattg
    21541 aagtttccat ttgcaatata acgaatttct tctatcattt tttttataca agtttcataa
    21601 taaagttttt tctcgtgacg ataaaaaatg taaagatagg atgaaaaaat agaaaataaa
    21661 aacaaataag atacaatcat catccataaa gactctttaa tccctttata cttttcataa
    21721 ccaaaaattc gaatgaattc tttaccgagt tcagttagag taagtgaact ctcaattaca
    21781 ctcgtaacga ggcgataaat aattagttca gtaataggag tgagtgtgat agctaataaa
    21841 agccaaaaaa taagtttcca tttaggaata tcttttaata tatcaaatgc ttcatttctc
    21901 aattttatag ccaactcccc aaacagtatg aatcaatttt tctccattca ttactgtttc
    21961 aagtttatct cgtaagttgc taatatggac cattaccgtc ttatttgaac cataaccatc
    22021 ttcattccaa acgcgttcga aaatttcttc tgaactaaat actcttcctg tattactcgc
    22081 aagtaaatat aaaatatcga attcaataga ggttagttta atatactctc catttacttt
    22141 aactgtatga ttatgtttgt gtatttcaac agagcgaata cgaataatac catcttcatt
    22201 cttttgcgaa gtagcatttt ggaaagagga tcttcgtaat aaagctttca ctctagctac
    22261 taattctaat ggattgaatg gtttgatcat ataatcatcg gcacctgtca taaggcctaa
    22321 tattttatcc atatcttctg cttttgcact aagcattaga attggtacag tattattttc
    22381 acgcacttcc tgacaaactt ctaatccgtt tcgttttggc atcataatat ccaaaatcat
    22441 aagatcaact tcatatgtag aaaccttttg caatgcttca tcgccatcat aagctttata
    22501 aatgttatag ccttcatttc gcaaataaac agcaagtaat tcaacaattt ctttatcatc
    22561 atcaataatt aatatatttt tattcattgt gtagttcctt tccttacaaa tcatcaacat
    22621 tactataata tcaaacattt atgtacttgt agcgatgatt ctgtataaaa tttcatgtaa
    22681 cgtattaaaa aggagtaaaa agattaataa cgaatataaa ataacaagga tatttagatt
    22741 ctacattata atggaagtta gttataaggg ggattttcta tgttatgtaa tgatatatat
    22801 ttatttactc caactggaaa aatagacaat gatattaaag cttttctact aaaatataat
    22861 aaagagttta catataaaca ttcaattcgt gtggcaaatg aggcaaaaaa gattgcagaa
    22921 aagtttcacg tagataaaga aaaagcagca attgcaggat atttacatga tattagtggc
    22981 atttttccga acgaggagcg gattgcagtt gctgaagaat ttggggtaga aatagtggaa
    23041 acagaaagaa aaattcctat gattattcat caaaaattat cgagagtaat cgcaaaagaa
    23101 atatttaaag tagaagatga agaaatttta aatgcaattt gttgccatac aacgttgcgt
    23161 aaacatgcaa cgaagatgga tttagtatta tttgttgcag ataaaataga atgggatcaa
    23221 aacgggacac caccatattt aatagaaata aaaaaaggat tggaaaaatc tttggaaaaa
    23281 gcagcttttg tatatatttc atatttgtgg gaaaggaaag atacattgaa agttatacat
    23341 ccgtggctag aagaagcata ctgggattta aaaggaattt tacagtagaa aggacaagga
    23401 aatgcaatta aaagaatata tgaatcaaac atttccagga gttacattag gaccctactt
    23461 atattctcag tggggaaatc atttacattt tgatttcgga aaagataaat atcaaattgt
    23521 agaaggaacc aacgatttaa atatggaata cttttctcaa ctatatacat ataataaatt
    23581 cttatttgaa gacatatttt caaaagaaga tgtagtgttt gtagtgacaa atgtttatag
    23641 atttaaaaag gaaaacataa aaactccaca gaaaataaat gtatacaata aatatattaa
    23701 gaaaagagat ttaagatttc atataagaca agaaacgtta ccgtttctat ttgaagatga
    23761 agaagcagat ttatattgta catatcattt ttctttaaaa tgtcttgcgg aagatattaa
    23821 gtatgaattg cttatacaag ctgctaatca cgaggatttc tctgctctgt atcctcgatt
    23881 tggacgaaaa aaagaaattt cttatccaga tgtatttctc ataaatgcaa cgaaagatat
    23941 tgtcatgttt atgtgtgatg atagaggatg tgaagtaatt gcgaagaata aagaaataat
    24001 acgagattta tataagaaat acaaagaatg gattccagat tatgaacgag aaagtataga
    24061 taacttattt aaatgacaat aggggaagtg aagcgtgtaa tgaaacgtat tgcaatagta
    24121 tctgcatggg aaccagaact gacgtatttg catcaacatt atccgagtga acgtgttgaa
    24181 aaaagagcag cttgggaatt tcattttcat actattaatg agctggaaat tatatcagtt
    24241 gttactggtg ttggtaaagt aagctgcgct agttgtgtac aattgttaat tagtgagttt
    24301 cagccagatg agttgtttat gacaggaata tgcggaagtt tatcaaacaa ggtgaaaaac
    24361 ggtcatattg tagtggcact aaacgcaata caacacgatg ttactgcagc tggctcaggg
    24421 gaagatgttt ttaatttata taacggtaga acagcaccta ttgaaacaac aaaatcactt
    24481 gtaagaagaa taaaaaaaat acgatcatat gatccaatac atttcggtac atttttatcc
    24541 ggagatcaac gtattcgtag ttcagaaatg agatatttac tccataccgt atatggagca
    24601 ttggcagttg atcaagaagt agcagctttc gcctatgtat gccaaataaa taaaaaacca
    24661 tttctatgtt taaaagctgc ttcagatcaa gcaaatgata aaacgaaaga agaacaaaaa
    24721 atctttaaaa tgctagcatg cgaaagagca tgtgagcatt taattgcttt tttgcgtgtt
    24781 tatgagatta atgtagtaaa taatagatag tttgttataa aacaaattaa tagtgggtta
    24841 tatgtaggga aatgtccgtt catttcaaat taagagctga aatttataat agatggaata
    24901 tattatatgg gtacatgttg cggttaatac aagcaattgg agggcaattt tatatgattc
    24961 aatataaaag atgtagtgaa gtaaatattg atttagtata tgaagctttt aaagatggat
    25021 tttccgatta tattattaag atggaagttt caaaaggtga ttttatacac cgttttttgg
    25081 gaccagaagg taatttgcta gaacattctt ttcttgcttt agacggtgac aaatcagttg
    25141 gcgtaatatt aggtggtata aaggattatg aaagtataaa gactatgcgc tgtggaacat
    25201 tagcggttca tcctaattac cgcggtattg gtgtcagtc
//
