LOCUS       NZ_CP011151            23507 bp    DNA     circular CON 28-JAN-2024
DEFINITION  Bacillus cereus strain CMCC P0021 chromosome, complete genome.
ACCESSION   NZ_CP011151
VERSION     NZ_CP011151.1
KEYWORDS    RefSeq.
SOURCE      Bacillus cereus
  ORGANISM  Bacillus cereus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5521782)
  AUTHORS   Wang,Y., Tian,W., Zhu,L., Wang,B., Wang,H. and Zeng,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-APR-2015) Institute for Biological Product Control,
            National Institutes for Food and Drug Control, No. 2, Tiantan Xili,
            Dongcheng District, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: RS_HGAP_Assembly v. V2
            Genome Coverage                   :: 35.03
            Sequencing Technology             :: Pacific Biosciences
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 08:42:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,142
            CDSs (total)                      :: 5,983
            Genes (coding)                    :: 5,793
            CDSs (with protein)               :: 5,793
            Genes (RNA)                       :: 159
            rRNAs                             :: 16, 16, 16 (5S, 16S, 23S)
            complete rRNAs                    :: 16, 16, 16 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 190
            CDSs (without protein)            :: 190
            Pseudo Genes (ambiguous residues) :: 0 of 190
            Pseudo Genes (frameshifted)       :: 77 of 190
            Pseudo Genes (incomplete)         :: 106 of 190
            Pseudo Genes (internal stop)      :: 68 of 190
            Pseudo Genes (multiple problems)  :: 50 of 190
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:21:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1297149
            Orig. end                         :: 1320656
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011151.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23507
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="3"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23507
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23507
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13507](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13507)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    238..254
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.11"
                     /tool="antismash"
     gene            504..1187
                     /locus_tag="WR47_RS06320"
                     /old_locus_tag="WR47_06515"
     CDS             504..1187
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001128612.1"
                     /locus_tag="WR47_RS06320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06515"
                     /product="YukJ family protein"
                     /protein_id="WP_063546861.1"
                     /transl_table=11
                     /translation="MPLKNYGVLKGTVIQSKMGKGKTPHYQVHLQDEAEVDYRIAINVK
                     SQSYPSEVLYFASNNIKSEAIHILPTLPFGFTEIKNNEPKVALDYVRGNLFDSKQMIPL
                     PPEKAGADNDLNEKIERYIKRAMEEKAIIYAFGERWGPEENTPDSYFHFKPGNGIHDIH
                     MNQGNVEKWQGDNGIWQDGGILIHFEKEEEWIGIFLAFQSQSWCTDEEGHARVPVEHCD
                     YKRSN"
     misc_feature    1219..1233
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.62"
                     /tool="antismash"
     misc_feature    complement(1265..1277)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            1352..1891
                     /locus_tag="WR47_RS06325"
                     /old_locus_tag="WR47_06520"
     CDS             1352..1891
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002186397.1"
                     /locus_tag="WR47_RS06325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06520"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_063546863.1"
                     /transl_table=11
                     /translation="MKITEENVVKQIKKRNEKSITFIIQTYGGLLSAIIKKYVQSNQQD
                     YEECLDDVLLAIWFHIDSFDSSKNTFKQWIAAIAKYRAIDYQRKNVRNQQQTVCTEIND
                     RLYQEQRKQNDFLDVQELLSELSATDRNIFEKYYLEGVPSREIASHLNVKESWIHNKLS
                     RGRKKLKQIFIFKNGV"
     gene            1896..2867
                     /locus_tag="WR47_RS06330"
                     /old_locus_tag="WR47_06525"
     CDS             1896..2867
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029762.1"
                     /locus_tag="WR47_RS06330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06525"
                     /product="DUF4179 domain-containing protein"
                     /protein_id="WP_063546865.1"
                     /transl_table=11
                     /translation="MSIYKELNDIQLDITEFEETPLTKLEEKQWEKRVKNKLRKNKHSK
                     KWFGVAAACMLIVSITVPLGQTSLANMPFIAGLIEKYIDKQQPLDYSPYKTAIGKTAEN
                     KYGKLTLNEVLVDENKLFISSTFEPAKGVKFDYQTYLIPQVRINGRDFSNAKDAQSIGV
                     NDSMFTIYGGVELSEMPQTDELQIEITYDTFNKDTVIEQPWIFDIEVSQAQLMKEKQTF
                     DLNETIALYDGNKVIVKKVVSTPISTTIYYDVPQSANEDIYFKIESESGKTYIFKEAFV
                     SNKGGDISFSRFDGINVAAGKYSLVPYSGKENEVIGPSIPIQ"
     gene            complement(2913..3746)
                     /locus_tag="WR47_RS06335"
                     /old_locus_tag="WR47_06530"
     CDS             complement(2913..3746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017762920.1"
                     /locus_tag="WR47_RS06335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06530"
                     /product="hypothetical protein"
                     /protein_id="WP_000424522.1"
                     /transl_table=11
                     /translation="MELVNSIFQILLTSVIQLLSLIGVIIVIGFLLGYLESLTRMYWSR
                     AFGRKGFLLTAWIGVPIHELGHAIMCVLFRHKIVATQFFPTDTSQGALGYIQHQYNQKS
                     VYQRIGNFFIGIGPIISGITALILLMRYFVPESYFLFNTTLEKTIASTSINVEMIQNML
                     LSTFVLLKSLFTIGNLLNPSFWLFLFIAICISAHIALSKPDIKGSIDGVVVMFIVLFLF
                     NIIAGLFQYDSNQLIGQVMKYNMYLIAFSSVALLFSCLSTLVSFSFYKIRRGRSF"
     gene            3943..4728
                     /locus_tag="WR47_RS06340"
                     /old_locus_tag="WR47_06535"
     CDS             3943..4728
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000650096.1"
                     /locus_tag="WR47_RS06340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06535"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_063546867.1"
                     /transl_table=11
                     /translation="MKCPSCHTENAVEAKFCGNCGHSLTEEVVASSGQEEGPEQARAAQ
                     AKEARPNETVEQAKRFASGYFQFFKHALQAPTAIMKSGAIEVRNGIVSLVLICFLGACI
                     FYRMMSAASAVTRTFAPDISTPTFLGESITVFFFLLILTLFVGFIIFVSGKMMKSSFSF
                     LEVFGIWGTIATPAIVILVLSFLFSFLLIFFLPILLSVVATYIGISITVAVLKLDNGGL
                     DLVYTLIIANVLIGIATFIVLWSYISTIIQALTQGITGF"
     gene            4748..5983
                     /locus_tag="WR47_RS06345"
                     /old_locus_tag="WR47_06540"
     CDS             4748..5983
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017672808.1"
                     /locus_tag="WR47_RS06345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06540"
                     /product="YARHG domain-containing protein"
                     /protein_id="WP_063546869.1"
                     /transl_table=11
                     /translation="MNVCTKCGVQFEDGVQFCQNCGMKRGSPVVKKNMSSGTKVGITLL
                     ALFVIAIIGLYLYGSSYYTQVAQVDRMITILQERDGEKLAEIVTADDPSVMITRESVTP
                     LFSYIKENPSYVNELKEYLRQGEKQRDGIERADFSLTKDGKYFFIFDRYKLKAKTYYTT
                     LLTNEKGVALKMNGKEIDKTDDKKFEKQYGPFLPGNQVFQSEYKNDYVKLSREEKVVLM
                     KQSQNNVTIDLTLQGQYITVQTNAPGATLYVNQKPVTALIGEEITWGPVATDGSATIYL
                     ERNGESGRETTQVETVTALSSYNLPFQTKSAEKTVVYNVTPPPTTGYVYNGFIFPDSDI
                     RKLMSADLTYLSKEQLKIARNEIYARHGHIFQTKDMQVYFAKQSWYRENLYFKGTLTDI
                     ETYNIELIKSRE"
     gene            complement(6030..6461)
                     /locus_tag="WR47_RS06350"
                     /old_locus_tag="WR47_06545"
     CDS             complement(6030..6461)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000332402.1"
                     /locus_tag="WR47_RS06350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06545"
                     /product="hypothetical protein"
                     /protein_id="WP_000332407.1"
                     /transl_table=11
                     /translation="MCAGLLAQLPDEPQEPKEPKPAVSLDQEFSINATIYSARAWLSND
                     DTFAQDIWKATQFASASHAGKSIFPVGSVKIINFSDDTITVTASPESDHALKIVVPPHS
                     EAALTSGPLSHIQASTSGGSSKVTFLFHIFFSRDPGPAK"
     gene            6659..7993
                     /locus_tag="WR47_RS06355"
                     /old_locus_tag="WR47_06550"
     CDS             6659..7993
                     /EC_number="1.8.1.14"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001110220.1"
                     /locus_tag="WR47_RS06355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06550"
                     /product="CoA-disulfide reductase"
                     /protein_id="WP_063546871.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.4e-65, bitscore:
                     217.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYVIIGGDAAGMSAAMQIVRNDENANVVTLEKGEIYSYAQCGLP
                     YVISGVIASTEKLIARNVKTFREKYGIDAKVRHEVTKVDTEKKMVYAEHTKTKDVFEFP
                     YDRLLIATGVRPVMPEWEGRELQGVHLLKTIPDAERILKTLETNKVEDVTIIGGGAIGL
                     EMAETFVELGKKVRMIERNDHIGTIYDADMAEYIHKEADKHHIEILTNENVKAFKGNER
                     VEAIETDKGTYKADLVLVSVGVKPNTDFLEGTNIRKNHKGAIEVNAYMQTNVQDVYAAG
                     DCATHYHVIKEIHDHIPLGTTANKQGRLAGLNMLDKRRAFKGTLGTGIIKFMDLTLART
                     GLNEKEAKGLHIPYKTVKVDSTNMAGYYPNAKPLYLKLLYRSDTKQLLGGQVIGEEGVD
                     KRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAARRAE"
     gene            8093..8581
                     /locus_tag="WR47_RS06360"
                     /old_locus_tag="WR47_06555"
     CDS             8093..8581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002135035.1"
                     /locus_tag="WR47_RS06360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06555"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_063546873.1"
                     /transl_table=11
                     /translation="MVVALQKVQELEKEILRNLYALYLHDLSKFTMNITIGANGFFEYE
                     DLHMFWKNDGITPYFIKVDHSIVGFLLLLERPFLKKENDFGINDIFILNQYKGKGIGKQ
                     AVENLLEEKRGQYFVIELLKNVPAVSFWKKVYKELNIEFDERAQLIDDEECLVQTFKF"
     misc_feature    8583..8597
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.04"
                     /tool="antismash"
     gene            8878..9288
                     /locus_tag="WR47_RS06365"
                     /old_locus_tag="WR47_06560"
     CDS             8878..9288
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996799.1"
                     /locus_tag="WR47_RS06365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06560"
                     /product="DUF3908 family protein"
                     /protein_id="WP_000996806.1"
                     /transl_table=11
                     /translation="MAINMKTIEEWIVESNTRHEEDFGHVVEEMKEVCVGLDNATLIYT
                     KNVFCFGKKVEVFFFFQDHVVIGQEKDEYIEIEKLKYDAITNSNLKTNDKNTTLELKFA
                     NGQSINLDSLNDNYGTKNWLFARQIKSIFKLI"
     gene            complement(9318..9908)
                     /locus_tag="WR47_RS06370"
                     /old_locus_tag="WR47_06565"
     CDS             complement(9318..9908)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (49-149). E-value: 2.4e-10. Score:
                     31.0. Matches aSDomain: nrpspksdomains_WR47_RS06370_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016109564.1"
                     /locus_tag="WR47_RS06370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06565"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_063546875.1"
                     /transl_table=11
                     /translation="MNILQRLIQQAKNPRGTIGSSMLCIMNAAHMRLTNWGLQKIHIRK
                     DAITLDIGCGGGKTIHTLSKRIPFGKIYGIDYSDQAVENSKKANIQDVKKGKVIIHQAS
                     VSSIPYNTNFFDLITAFQTHYFWPDVEQDIKEIFRVLQPNGSFLLVAETFKIQYHMEKW
                     KTNEELINLFYKTGFTSVKCYEERGCLCVIGIK"
     aSDomain        complement(9462..9761)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_WR47_RS06370_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.40E-10"
                     /label="WR47_RS06370_oMT.1"
                     /locus_tag="WR47_RS06370"
                     /protein_end="149"
                     /protein_start="49"
                     /score="31.0"
                     /tool="antismash"
                     /translation="LDIGCGGGKTIHTLSKRIPFGKIYGIDYSDQAVENSKKANIQDVK
                     KGKVIIHQASVSSIPYNTNFFDLITAFQTHYFWPDVEQDIKEIFRVLQPNGSFLL"
     gene            complement(10001..11542)
                     /locus_tag="WR47_RS06375"
                     /old_locus_tag="WR47_06570"
     CDS             complement(10001..11542)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016124293.1"
                     /locus_tag="WR47_RS06375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06570"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_063546877.1"
                     /sec_met_domain="PF00881 (E-value: 2.7e-08, bitscore: 32.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLDTFLHHLHFSIDEIMPNHEVDWKDAPLPYKLYRNVPTIPLSL
                     EIPLSLSNSSTTPTLNEIGHYLWYSFGVTQLCQLNSERNVLRRSIPSGGALYPNELYIY
                     LKIDDYPDGIYHYDAAHHRLILLREGNFDSYLADALGNRCNIHDCFGAAFVSTMFWKNF
                     FKYNNFSYRLQGLDSGVLIGQLLECAKQFGYTNGVYFQFLDRALNHLLGLSEGEESVYA
                     VIPLSTEPETNWFHNDYRENKTVTSHELLQQIPPLAHEHFVRSKHVNEHPMITKINEAS
                     MIESTEHFQTLHHEEHYQHNTYAVQLPKVERLSYDFLQLCKKRYSPDADFILRKWDASE
                     LATLLQEASLSFPYYSDLDGKYLNENARVSLYGCFYNVKNIKNGAYAYNSKTHSIQPIR
                     YGDLRYPLQSSMTMDNVNLFQVPLCLHVVGKKGYYTHALGYRGYRIHQMEAGILVHKLV
                     FAATAMGMGGHPLLSFDTNSCDQLYGIDAGNETSLIQVPVGAYRARNWLKGALHN"
     gene            complement(11558..13507)
                     /locus_tag="WR47_RS06380"
                     /old_locus_tag="WR47_06575"
     CDS             complement(11558..13507)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191877.1"
                     /locus_tag="WR47_RS06380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06575"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_063546879.1"
                     /sec_met_domain="YcaO (E-value: 4.2e-84, bitscore: 281.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.2e-143, bitscore:
                     475.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRNILLIGDGLLADYVHDQLCEQYSIIRQHTITEELPENIHLAL
                     VLHDGSPSTIHHDAELIFRSNHIPWLRGFTSFGEGIIGPYIHPLSSGCSHCSDGRRFIA
                     GFDQQEMWELQRKYAFKADNVTRRDVRATQNGMLQMCHLIRVETEKILTHNHSSLENEL
                     ILLNLQTLQCTRHSFLPDPLCPICSNLPDDTADAAELSLQPSLKVSTETYRCRSIHELN
                     TFLTRDYLDYRVGMLNGKMQHSLLPFADVIINMPLMFGNEGVAGRTHSFAVSEATAILE
                     GLERYCGMSPRGKKTNVHGSFHDLEEHALNPLTLGVHTNEHYNRDKFPFKPFDPDYEQN
                     WVWGYSLSQNRPLLVPESIAYYSLGHRDAFVYETSNGCAIGGSLEEAIFHGILEIVERD
                     AFLLTWYAELPLPRLDLSSANDTELQLMIQRLRTITGYELHAFNATMEHGIPSLWVIAK
                     NTRENGMNVVCAGGAHLDPIRALKSAIQEIAGMLLITDDELEHKREYYEKCLQDPYFVN
                     KMEDHSMLYGLKETEERLHFLLREDAPVQTFQEMNVSQSFDMDLTSDLHQLLNRLHQSN
                     LEIIVVDQTVPLIEKNGLHCVKVIIPGMLPMTFGHHLTRVTGLDRVYTVPMTLGYSTEP
                     LTNEQLNPHPHPFP"
     gene            complement(13504..15423)
                     /locus_tag="WR47_RS06385"
                     /old_locus_tag="WR47_06580"
     CDS             complement(13504..15423)
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513905.1"
                     /locus_tag="WR47_RS06385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06580"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_001061546.1"
                     /sec_met_domain="TIGR03693 (E-value: 0.0, bitscore: 1219.0,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     6.5e-55, bitscore: 181.5, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 4.3e-11,
                     bitscore: 41.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGAGIYDW
                     IEKLMPMFNGNYSLAEITDGLPLPYQNRVFEIGEILYENGFVRDTNQDEPHELNSTLLD
                     RYASQIEFLEADSHSGALKFETYRGANVLVLGSGDMLTSLVSSLLESGLPTFHYLVTDR
                     DETNYDRIHELIERAYEVDNTVLLQEIDTTIDRPLHEVFEPFDWILYVSQNGDIDGLKT
                     VHTICREAKKNFIPAICLSTLGIAGPVVTENRDECWESAWHRLHETTLQNENSSDSFSP
                     ITSAMLANVIVFELFKHVADDSHREKGSQFFLLNYETLEGTWHPFIKHPLATDESFTID
                     TIENLSEKLEHRSNQHTSTDVFQFFDSLTSKEAGIFHVWDEQDSYQLPLSQCYIQVANP
                     LSDGPAPLLPLMTCSGLTHNEARREAGLTGIETYVAEIIHRLIPEHNDIGIGAGETMTE
                     GFYRALQQHLNNKLYERQSHTLEELTTIDLTDIHDKHCRFYYDALSTIHETPTIAMSEE
                     ILSFPVVWIGINDRWYGASNINMTLALRNALQLALFHIQNEEIPYRANILYDSSIILYD
                     TDSFRVEIQPEEEIPNVQSLQLALQHLEEHNFYPFVFDLAIEPFLKENLDGVYGVLIAK
                     EDGL"
     aSDomain        complement(15124..15423)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_WR47_RS06385_Heterocycloanthracin_C_R
                     RE.1"
                     /evalue="3.30E-57"
                     /identifier="RREFam011.1"
                     /label="WR47_RS06385"
                     /locus_tag="WR47_RS06385"
                     /protein_end="100"
                     /protein_start="0"
                     /score="181.5"
                     /tool="antismash"
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGAGIYDW
                     IEKLMPMFNGNYSLAEITDGLPLPYQNRVFEIGEILYENGFVRDTNQDEPHELNS"
     aSDomain        complement(15157..15393)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_WR47_RS06385_Thiopeptide_F_RRE.1"
                     /evalue="2.20E-13"
                     /identifier="RREFam004.1"
                     /label="WR47_RS06385"
                     /locus_tag="WR47_RS06385"
                     /protein_end="89"
                     /protein_start="10"
                     /score="41.0"
                     /tool="antismash"
                     /translation="KVNKDTFFLPDSNGGVYFRNNASSFRMDGAGIYDWIEKLMPMFNG
                     NYSLAEITDGLPLPYQNRVFEIGEILYENGFVRD"
     gene            complement(15548..16807)
                     /gene="odhB"
                     /locus_tag="WR47_RS06390"
                     /old_locus_tag="WR47_06585"
     CDS             complement(15548..16807)
                     /EC_number="2.3.1.61"
                     /GO_component="GO:0045252 - oxoglutarate dehydrogenase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004149 - dihydrolipoyllysine-residue
                     succinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="odhB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716916.1"
                     /locus_tag="WR47_RS06390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06585"
                     /product="2-oxoglutarate dehydrogenase complex
                     dihydrolipoyllysine-residue succinyltransferase"
                     /protein_id="WP_000569892.1"
                     /transl_table=11
                     /translation="MIEIKVPELAESITEGTISQWLINVGDKVEKGGSVVELETDKVNV
                     EIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAPVAVSTPAPAAEQPKQETAEAPKA
                     AAPNAEQTTGLQGLPNTNRPIASPAARKMARELGIDLNDVRSTDPLGRVRPHDVQAHAA
                     APKEAPAAPKSPAPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVD
                     MSAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYD
                     IGIAVAAPDGLVVPVVRDANQLNFAEIESEIRNLGMKARDNKLSLKELQGGTFTITNGG
                     VFGSLMSTPILNSPQVGILGMHKIQVRPVAIDAERMENRPMMYLALSYDHRIVDGKEAV
                     SFLVAVKDMLEDPKSLLLEG"
     gene            complement(16941..19808)
                     /gene="odhA"
                     /locus_tag="WR47_RS06395"
                     /old_locus_tag="WR47_06590"
     CDS             complement(16941..19808)
                     /EC_number="1.2.4.2"
                     /codon_start=1
                     /gene="odhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000197121.1"
                     /locus_tag="WR47_RS06395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06590"
                     /product="2-oxoglutarate dehydrogenase E1 component"
                     /protein_id="WP_063546881.1"
                     /transl_table=11
                     /translation="MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFE
                     IFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAA
                     NGQSLLEKAMSELSDADLKAIPAKTVWQDAPEGIHTALDVIHRLKDVYTKSLAYEFSHI
                     QDSEERAWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGV
                     DMLVPVLDEIVLEGAKNGVEDVMIGMAHRGRLSVLAHVLEKPYSHMFAEFKHAKIEGAV
                     ANSGWTGDVKYHLGREQVVSNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSG
                     LPDQDTSKSFVILVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSY
                     DSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRMLFKKDFLIDLIGYRRYG
                     HNEMDDPAVTQPQVYKKIKNHPTVRAIYAEQLQAAGVLNADEIETITQFIQEQLKSDYA
                     QVPLADTSDATIHVKVPDVVAKGIQPIDTGVELDSLRAINEGLLSWPEGFNVYPKVKKI
                     LERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTETN
                     ETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQA
                     LFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSA
                     AQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGT
                     KPNKVKRLVLSTGKMAIDLAAEIESGKHEYNLDEVHVVRIEQLYPFPAEKVQSIIKRFK
                     NLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQE
                     LIVAHALDVKYNFRQDKLEIEVYSN"
     misc_feature    complement(20222..20242)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.69"
                     /tool="antismash"
     gene            20633..20842
                     /locus_tag="WR47_RS06400"
                     /old_locus_tag="WR47_06595"
     CDS             20633..20842
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428510.1"
                     /locus_tag="WR47_RS06400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06595"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000428506.1"
                     /transl_table=11
                     /translation="MENKMVEYRKKFGLSQEKLAEKLGVSRQTIISIEKGKYDPSLPLA
                     FEIAKTFQTTIEHVFIYEGKEEGE"
     gene            20845..21222
                     /locus_tag="WR47_RS06405"
                     /old_locus_tag="WR47_06600"
     CDS             20845..21222
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016101524.1"
                     /locus_tag="WR47_RS06405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06600"
                     /product="hypothetical protein"
                     /protein_id="WP_048564894.1"
                     /transl_table=11
                     /translation="MNYSQKYFVIMGVIFLFMSGFMILTGIMTHSAPPAITYPLLGMMI
                     MSFCLSYLHPQFKEKDERMKLIRYKGMFVTFFALTAYYLLFSIGLNLKILTLSATELLN
                     ILMALTMSTVFISFVVLAKRY"
     gene            21251..21433
                     /locus_tag="WR47_RS06410"
                     /old_locus_tag="WR47_06605"
     CDS             21251..21433
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086895.1"
                     /locus_tag="WR47_RS06410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06605"
                     /product="DUF3976 domain-containing protein"
                     /protein_id="WP_001178303.1"
                     /transl_table=11
                     /translation="MQMMYAFGIGLVLFLAVFLFIRKDVQGGTLTKRGFYKMIGCLVVM
                     FIAIIVMIVLISRSL"
     gene            21580..21928
                     /locus_tag="WR47_RS06415"
                     /old_locus_tag="WR47_06610"
                     /pseudo=""
     CDS             21580..21928
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034134.1"
                     /locus_tag="WR47_RS06415"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06610"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFYLLTCLLLVASTAYYNM"
     gene            21957..22208
                     /locus_tag="WR47_RS06420"
                     /old_locus_tag="WR47_06615"
     CDS             21957..22208
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126037.1"
                     /locus_tag="WR47_RS06420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WR47_06615"
                     /product="hypothetical protein"
                     /protein_id="WP_140157268.1"
                     /transl_table=11
                     /translation="MSYPWVLRKTFFLCFILSPIGAACILMNRGAIQKRDFILYLLFAA
                     MNISLWLLLMIFDWSMWMVVGHYLFGAVVIVFSNMNKS"
     gene            22296..>22439
                     /locus_tag="WR47_RS30345"
                     /pseudo=""
     CDS             22296..>22439
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014654109.1"
                     /locus_tag="WR47_RS30345"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="WXG100 family type VII secretion target"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKVTPERLEQTAKTVNNIRHFLEYLHNDLYNQIKNIAIQWNGASR
                     EQF"
ORIGIN
        1 atttgattta gccgacttgt aacgagcaat tacagttttc atcacagatt gagccatttg
       61 actttttaac ctaaattgat ttcgcaaatc agaataatat aagttattga gatttacttg
      121 attaaggttc tttgtttcaa atatgtgttt tgataaccaa ttacaagcct tgcggtaagc
      181 gttcgttgtt atctttagac tttcagcttg attatcggaa acatggattt gtatttttgc
      241 agtaattgta ggcattattt tcaccgcctt tcactaatta aattgtaaca gatttttagt
      301 gaaagcaaac aacttaagta gagaaagtag gaggcaaggt ggaagtttca gatacttgat
      361 atggtacaga atcttaggat ttttaacgta ccataccgta tctgccggca attcctcccc
      421 cacttatcgt tgggctatcg cccttcacac gattgaagta gggggtatcc ttgccgattt
      481 tagatgaata ggagatgaaa tgtatgccct taaaaaatta cggcgtgtta aaaggtacag
      541 ttatacaatc aaagatggga aaagggaaaa ctcctcatta tcaagttcat ttacaagatg
      601 aagcagaagt agattatcgt attgcaatta acgtaaaatc acaaagttat ccgtcagaag
      661 ttttatattt tgcgagtaac aatattaagt cagaggcgat tcatatttta ccgacattac
      721 cattcggttt tacagaaata aaaaacaatg aaccgaaagt agctttagat tatgtaagag
      781 gaaatctatt tgactcaaaa caaatgattc ctttgcctcc cgaaaaagca ggagcagata
      841 atgatttaaa cgaaaaaata gaacgttata taaagcgagc gatggaagaa aaagcaatta
      901 tttacgcgtt tggcgaaaga tggggaccag aagaaaacac accagattct tattttcatt
      961 tcaaaccagg aaacggtata catgatattc acatgaatca agggaatgta gaaaaatggc
     1021 aaggagataa tggtatatgg caagatggag gaatacttat tcactttgaa aaggaagaag
     1081 aatggattgg tatctttctt gcattccaat cacagtcatg gtgtaccgat gaagaggggc
     1141 atgctcgtgt tccggttgag cattgtgatt ataagagaag taattaaagg gaagagctag
     1201 ttcgtaatga actagctctt ctcattatga acaagatata tgttgtttaa tggtgaaatt
     1261 gtgtttgcaa tatgaaaaac agtgataggg ttattgtttt tcattcgtat tagaaagtag
     1321 ataccaatta gcagtacaag gaggtctacc tttgaagata acggaagaaa atgttgtaaa
     1381 acaaattaaa aaacgtaatg agaaaagcat tacgtttatt attcaaacat atggaggatt
     1441 actcagcgct attattaaaa aatatgtaca gagcaatcag caagattatg aagaatgctt
     1501 agatgatgta ttattagcga tttggtttca tatcgattca tttgattcaa gtaaaaatac
     1561 gtttaaacaa tggatagcag ccattgcaaa atatcgggca attgattatc agcgaaaaaa
     1621 tgtgagaaat cagcaacaaa ctgtctgtac ggagattaat gatcgtctgt atcaagaaca
     1681 aagaaaacaa aatgacttct tagacgtaca ggaactgctt agtgagttgt cagcaacaga
     1741 tcgtaacatt tttgaaaagt attatttaga aggtgtaccg tctcgtgaaa ttgcatccca
     1801 tcttaacgtg aaggagtcat ggattcataa caaactgtca cgcggacgaa aaaagctcaa
     1861 acagattttt atttttaaaa atggagtgtg agggcatgtc tatttataaa gagttaaatg
     1921 atattcagtt ggatatcaca gagtttgagg agactccctt aaccaaacta gaggaaaagc
     1981 agtgggaaaa acgtgtgaaa aataagctcc gtaaaaacaa acattcaaaa aaatggttcg
     2041 gagtcgcagc agcttgcatg ctaattgtca gcattacagt gccgcttgga caaacatctt
     2101 tagcaaatat gccatttata gcgggattaa ttgaaaaata tattgataaa cagcaaccac
     2161 ttgactattc tccctataaa acggctattg ggaaaaccgc tgaaaataaa tacggtaaac
     2221 tgactttaaa tgaggtacta gtggatgaaa ataaattatt tatcagttca acatttgagc
     2281 cagcgaaagg tgtgaaattt gattaccaaa catatttaat tccacaggta cgaataaatg
     2341 ggcgtgactt ttctaatgca aaggatgcac aatcaattgg agtaaatgat tctatgttta
     2401 caatttacgg tggtgttgag ttaagtgaaa tgccacaaac tgatgaactt caaatcgaaa
     2461 ttacttatga tacattcaac aaggatactg taattgagca accatggata tttgatatag
     2521 aagtatcaca agctcagttg atgaaagaga agcagacgtt tgatttaaat gaaacaattg
     2581 ctttatacga tggcaataaa gtaattgtta aaaaagtagt ttctacgccg atttccacaa
     2641 caatttatta tgatgtgcca caaagtgcaa atgaagatat ttattttaaa atcgaatcag
     2701 aatctggaaa aacatatata tttaaagagg catttgtatc gaataaaggc ggagacattt
     2761 cttttagtag atttgatgga attaatgtag cggcgggaaa atattcactt gtaccgtatt
     2821 cggggaaaga aaacgaagtg attggaccat ctattcccat tcaataactt attaaatctg
     2881 ataaataatt atttaaagat agaagagggc gttcaaaaag aacgccctct tcttatttta
     2941 taaaacgaaa aactaacgag tgttgaaaga caagagaaca gcaatgccac actagaaaac
     3001 gcaatgagat acatattata tttcataacc tgtccaatta gctgattact gtcgtattga
     3061 aacagtcctg ctattatgtt gaataaaaat aacacgataa acatgacgac aacaccgtct
     3121 attgatcctt taatgtctgg tttacttaaa gcgatatgtg cggaaatgca aatggcgata
     3181 aataaaaata accaaaagga aggattcaat aaattgccga ttgtaaataa gcttttcaat
     3241 aatacaaacg tcgacaagag catgttttga atcatttcta cattaataga agtagaagca
     3301 atcgtttttt cgagagttgt attaaataaa aaatatgatt ctggtacgaa atagcgcatt
     3361 aaaaggatta atgcagtaat accagaaata ataggcccaa tgccgataaa gaaattccca
     3421 attcgttgat acacactttt ttgattgtat tgatgttgta tataacctaa agccccttga
     3481 cttgtatctg ttgggaagaa ctgagtcgcc acaattttat gacggaacag tacgcacata
     3541 atggcatgtc caagttcgtg aatcggaaca ccgatccaag ccgttaatag gaatcctttt
     3601 cttccaaaag ctctcgacca atacatgcgt gtgagagatt ctaaatagcc taatagaaat
     3661 ccaattacaa tgataacgcc aattaaagat aataattgga ttacgcttgt aaggagtatt
     3721 tgaaaaattg agtttaccaa ttccattttc tttcatccaa tctgttaaaa atattattta
     3781 ttctgtttca taatagcatt ttttttcaag attgctagca catatatttt ctttcggaag
     3841 aaggatttca gaatcttttt cttgtagtca tgttttatgt acaaattcat atattgaact
     3901 tgtaacaccc tataaggtat atgcttaagg agggataaga gaatgaaatg tccgtcatgt
     3961 catacagaaa atgcagtaga ggcaaagttt tgcgggaatt gtggacattc gttaacggaa
     4021 gaagtagtgg caagtagtgg ccaagaagaa gggccggaac aagcacgtgc ggcacaagca
     4081 aaggaagctc ggccaaatga aacggtagag caagcgaagc ggtttgcgag cggctatttt
     4141 caatttttta aacatgcatt acaagcaccg acagcgatta tgaaaagcgg cgctattgaa
     4201 gtgcgaaatg gaattgtaag tcttgttctt atttgttttt taggagcatg tattttttat
     4261 agaatgatga gtgcagcatc agcagttacg agaacatttg caccagatat atctactccc
     4321 acgtttttgg gagaatctat aacggtcttt ttctttttat taattttaac tttatttgtc
     4381 ggatttatta tttttgtaag tggtaagatg atgaaatcat ctttttcatt tcttgaagta
     4441 tttggtatat ggggaacgat agcgacgccg gctattgtca tattagtcct ttcttttctt
     4501 tttagtttct tattaatctt tttcttaccg atattattat cggtagttgc aacttatata
     4561 ggcattagta taactgtagc cgtattaaag ctagacaatg gcggattaga tctcgtttac
     4621 acacttatta ttgcaaatgt tttaattgga attgcaacat tcattgtact ttggtcttac
     4681 attagcacga taattcaagc cttaacacag ggaataactg gcttctaatg aaaaggtggt
     4741 tgactgaatg aatgtatgta caaagtgcgg agttcagttt gaagatggtg tgcaattttg
     4801 tcaaaactgc gggatgaaga ggggaagtcc tgtagtaaag aagaacatga gcagtggtac
     4861 aaaagttggc attacactgt tagcactatt tgttatagcg attattggat tatatttgta
     4921 cggatcatcg tattatacgc aggtggcaca agtagaccgg atgattacga ttttacaaga
     4981 gcgggacgga gagaaattag ctgagatcgt tacggcagat gatccatcgg ttatgataac
     5041 gagagagagt gtaacgcctc tattttcata tataaaagaa aatccatctt acgtaaatga
     5101 attaaaagaa tatttgagac aaggtgaaaa acaacgggac ggaatagaaa gagctgattt
     5161 ttcattaacg aaagacggga agtatttctt tatatttgat cggtataaat tgaaagcgaa
     5221 gacgtactat acaactttgc ttacaaatga aaaaggcgta gcgttaaaaa tgaacggaaa
     5281 agaaattgat aagacagatg acaaaaagtt tgagaagcaa tatgggccgt ttcttccagg
     5341 gaatcaagtg tttcaatcag aatataaaaa tgattatgta aaactatcgc gtgaggaaaa
     5401 ggttgtactt atgaaacaaa gccaaaataa cgtaacgata gatttaacgt tgcaaggtca
     5461 atatattaca gttcaaacga acgcgcctgg tgcaacattg tacgtaaatc aaaaaccggt
     5521 tacagcgctg ataggagaag aaattacatg ggggccagta gcgactgatg gaagtgcgac
     5581 gatttattta gaacgaaatg gagaaagcgg acgagaaacg acacaagtag agacggtaac
     5641 ggcactttcg tcttataatc ttccattcca aacgaaaagt gcagaaaaaa cagttgttta
     5701 taatgttacc ccgccaccta cgactgggta tgtatataat ggtttcatct ttcctgatag
     5761 tgatattcga aaattaatga gcgcagattt aacatattta tcgaaagagc agttaaaaat
     5821 tgctagaaat gaaatatatg caaggcatgg acatattttt caaacgaaag atatgcaagt
     5881 gtattttgca aaacagtctt ggtatagaga aaatctttat tttaaaggaa cgttaacaga
     5941 tattgaaact tataatattg aactaatcaa atcaagagaa tagagcactt gaaaaaggta
     6001 cagtgtatat tgctgtacct tttctatcgt tatttagctg gaccaggatc ccttgagaaa
     6061 aagatatgaa agagaaatgt gactttactt gatcctcctg atgtactagc ttgtatatgt
     6121 gataaaggac cagacgttag agcagcctcg gaatggggtg gtacgactat tttgagcgca
     6181 tgatctgatt ctggtgaagc agtaacagta attgtatcat cagagaagtt tataatttta
     6241 acagaaccga ctggaaagat ggacttgcca gcatgtgatg ctgaagcgaa ttgggtagct
     6301 ttccaaatat cttgcgcaaa cgtatcatcg ttagataacc aagcacgagc gctatatatt
     6361 gttgcattaa tggaaaattc ttggtcaagt gagacggcgg gtttcggttc ttttggttct
     6421 tgcggttcat ctggaagctg ggcgagaagg ccggcgcaca tacatttcac ctactttcaa
     6481 tagtaactgt tatagcatat taaacatgtt gtttataaga cacgacagtt acctattcgc
     6541 gtataagttt gtgcaacaaa tttgaagata aaattctctt tctttacaat ggagttaggt
     6601 gttatttcta taaaatatgg aaaacgtaaa gagtatgtaa aaaagaagga gtggtaaagt
     6661 gaactatgtc attattggcg gagatgcagc tggtatgagt gcagctatgc aaattgttag
     6721 aaacgatgaa aatgcaaatg ttgtaacttt agaaaaaggt gaaatttatt catacgctca
     6781 gtgtggatta ccgtatgtca ttagtggtgt tatcgcttca actgaaaagt taatcgcgcg
     6841 caatgtaaag acgtttcgtg agaaatatgg aattgatgcg aaagtgcgtc atgaagtaac
     6901 gaaagtagat acggaaaaga aaatggtgta cgcagagcat acgaagacga aggatgtctt
     6961 tgaatttcca tatgatcgat tattaattgc gactggagta cgtcctgtta tgccagaatg
     7021 ggaaggacgg gaattacaag gcgttcatct tttaaaaaca attccggatg ctgagcgcat
     7081 attaaaaacg ttagaaacga ataaagttga agatgtaacc attattggtg gtggtgcaat
     7141 cggactagag atggcagaaa cattcgtcga acttggtaag aaagtaagaa tgattgagcg
     7201 aaatgatcat atcggtacga tttatgatgc agatatggca gagtacatac ataaagaagc
     7261 agataagcat catattgaaa ttttaacgaa tgaaaatgta aaagcattta aaggaaatga
     7321 acgagtagaa gcaatcgaaa cggataaagg tacgtataaa gcagatcttg ttttagtgtc
     7381 ggttggagtg aagccaaata ctgattttct tgaagggaca aatatacgta agaatcataa
     7441 aggagcaatc gaagtaaatg catatatgca aacaaatgtg caagacgtat atgcagccgg
     7501 tgattgcgca acacattacc acgttataaa ggaaattcat gatcatatcc cgctcggaac
     7561 gactgccaat aagcaagggc gacttgctgg actgaatatg ctggataaac gaagagcctt
     7621 taaaggtacg ttaggtacag gtattattaa atttatggat ttgacgcttg caagaacagg
     7681 attaaatgaa aaagaagcga aagggctaca catcccgtat aaaacagtca aagtagattc
     7741 gactaatatg gcgggctatt atccaaatgc gaaaccactt tacttgaaat tactataccg
     7801 ttctgacacg aaacaattat taggcggaca agtaattgga gaagaaggcg tagataaacg
     7861 tattgatgta atcgcaatgg cactcttcaa taaaatgagc attcacgatt tagaagatgt
     7921 cgacttaagt tatgccccac catataacag cgtttgggat ccaattcagc aagcggcaag
     7981 gagagcggaa tagcactttt taaagtgcta tttttttcgt taaaggggaa taattatttt
     8041 tggcgaataa aaaaggggga aatagttata gatagggaag gggatttttt taatggttgt
     8101 agcacttcaa aaagttcaag aattagaaaa agaaatatta cgcaatttgt acgcattata
     8161 tcttcatgat ctttctaagt tcactatgaa tataactatc ggagcgaacg gattttttga
     8221 atacgaagat ttgcatatgt tttggaaaaa tgacggaatc acgccgtatt ttataaaagt
     8281 tgatcatagt attgtaggat tcttattact actggaacgt ccgtttttga agaaggaaaa
     8341 tgattttggt attaatgata ttttcatatt gaatcaatat aaaggaaaag gaatcggtaa
     8401 acaagctgtt gagaatttac tagaagagaa aagaggacaa tatttcgtta tcgaacttct
     8461 aaaaaatgta ccagcagtgt cgttttggaa gaaagtatat aaagaactaa acattgaatt
     8521 tgatgagaga gcgcagctaa ttgatgatga agaatgtctc gttcaaacgt ttaaatttta
     8581 atggaattgg tgttcctttt atattaattt gaaatttaac tttatcccgc tatttgcggg
     8641 cagtaagacc cccatctcaa aatccagcga aagcaaagaa gttaggtggg tgatcaactg
     8701 cccgtaaaag cccgattggt tcaactaata atcagtgggg atgaagaccc ctattgatta
     8761 aagtttcact ttattttgaa tataccgttc ccccttgaaa acatattact aatcgcttat
     8821 attttcatat agtatttatt tttttaacga agcaatgaac gaaccagggg gcgcagtatg
     8881 gcaattaata tgaaaacaat cgaagaatgg attgttgaat caaatacaag acatgaagaa
     8941 gactttggac acgttgtgga agaaatgaaa gaagtatgtg tcggacttga taacgcgaca
     9001 ttaatttata cgaaaaatgt attttgtttc ggtaaaaaag tagaagtatt tttcttcttc
     9061 caagaccatg tcgtgatcgg acaagaaaaa gacgaatata ttgagattga aaaattaaag
     9121 tatgatgcca ttacaaatag taatttaaaa acaaatgaca aaaatacaac gttagaatta
     9181 aagtttgcta acggacaatc tattaattta gatagtttaa atgataacta cggtacgaaa
     9241 aattggttat ttgctagaca aattaagagt atttttaagt taatctagta aaaagcagac
     9301 ctcaaagggt ctgcttttta cttaattcct attacacaaa ggcaacctct ttcttcatag
     9361 catttcacac ttgtaaatcc tgttttataa aataggttta ttaattcttc attcgttttc
     9421 catttctcca tatgatattg aattttgaaa gtttcagcta ctaataaaaa agatccattc
     9481 ggttgtaaga cgcgaaatat ttcttttata tcttgttcca catcgggcca aaagtagtgt
     9541 gtttgaaaag cggttatgag atcgaagaag tttgtattgt aaggaataga ggagacactt
     9601 gcctgatgaa tgattacttt tccttttttt acgtcctgta tattggcttt ctttgagttt
     9661 tcaacagctt gatctgaata atcaattcca tatattttcc caaatggaat tcgttttgaa
     9721 agagtatgta ttgttttgcc gccgccacaa ccaatatcta aagtaattgc atctttacgt
     9781 atatgtattt tttgtaatcc ccaatttgtt agtctcatat gtgcagcgtt cataatacaa
     9841 agcatggaag aaccaatggt cccgcgaggg ttttttgctt gctgaattaa tcgttgtaaa
     9901 atgttcaagt tacattctcc ttttatgtaa gaatatatac tcatttcgct ttttataaat
     9961 taagtccttt aaaaaaagca cgccgtctac cggcgtgctt ctaattatgc aaagcccctt
    10021 ttaaccaatt ccgcgcccga tacgccccaa ctggaacttg aataagagac gtttcattcc
    10081 cagcatcaat tccgtacaat tgatcacatg aatttgtatc aaaacttagt aaaggatgcc
    10141 cgcccatccc catagcagtt gcagcaaaaa cgagtttatg aacgaggata ccagcttcca
    10201 tttggtgaat acggtatcct ctatagccta atgcatgtgt atagtaacct ttctttccga
    10261 ctacatgtaa gcaaagcggt acttgaaaaa ggtttacgtt atccatcgtc atactagact
    10321 gaagtgggta gcgaaggtct ccataccgaa ttggttgtat ggaatgtgtt ttactgttat
    10381 aagcgtaagc cccgttttta atatttttca cgttataaaa acatccatat aaggagacgc
    10441 gcgcattttc atttaaatac ttaccatcaa ggtcgctgta ataagggaag gagaggctcg
    10501 cttcttgtag taaagtagcg agctcagatg catcccattt ccttaaaata aagtccgcat
    10561 caggagaata tcgtttttta caaagttgta ggaaatcata cgataaccgt tctactttcg
    10621 gtagctgtac agcgtacgta ttatgttgat agtgctcttc atgatgtagt gtttggaagt
    10681 gttctgtcga ttcaatcata gaagcttcat ttatttttgt tatcatcgga tgttcattta
    10741 catgttttga gcgaacgaaa tgttcatgtg ctaacggcgg aatttgttgc aacaactcat
    10801 gagaagtaac tgttttattt tcacggtaat cattgtgaaa ccaattagtt tctggctctg
    10861 tacttaaagg aataacggca tacacacttt cttcaccttc tgacaatccg agtaaatggt
    10921 tcagtgcacg gtctagaaat tgaaagtata cgccgttcgt ataaccgaac tgttttgcac
    10981 attctagtaa ttgtccaatg agaaccccgc tatctaatcc ttgaaggcga tatgaaaagt
    11041 tattgtattt aaagaagttt ttccaaaaca tagtggatac gaatgcggca ccgaaacaat
    11101 catgtatatt acagcgatta ccgagtgcgt ctgctaaata agaatcgaaa tttccttcgc
    11161 gaagtaaaat aagtcggtga tgcgcggcgt cataatggta aatgccatct ggataatcgt
    11221 caatctttaa atagatatac aattcattcg gatataaagc accgcctgaa ggaatggatc
    11281 tgcgtaatac atttctctcg ctatttagct gacataattg tgttacacca aatgaatacc
    11341 aaaggtagtg accaatctca tttagagtag gtgtagtaga agagttcgat aaagataacg
    11401 ggatttctaa ggagagcggg atggtaggta catttcgata taatttataa ggaagcggtg
    11461 cgtctttcca gtccacctca tgattcggca taatttcatc aatagagaaa tggagatgat
    11521 gtaaaaaagt atctagctgc atgaaatccc tcctttacta tggaaacggg tgcggatgtg
    11581 gatttaattg ttcatttgtt aacggttcag tgctatatcc aagtgtcatc ggtacggtat
    11641 agactctatc taatcctgta acacgagtaa ggtgatggcc gaatgtcatc ggtaacatgc
    11701 ctggaataat gacttttaca cagtgtagtc cgttcttttc tataagggga acggtttgat
    11761 ctacaacgat tatttcaaga ttagattgat gcaaacgatt taaaagttgg tggagatcgg
    11821 atgttaaatc catatcaaat gactgtgata cattcatttc ttggaacgtt tgcactggtg
    11881 catcttctcg taaaaggaag tgaagacgtt cttccgtttc tttcaatccg tacagcatac
    11941 tgtggtcttc cattttatta acgaaataag gatcttgtaa gcatttttca tagtattctc
    12001 ttttgtgctc gagttcatcg tctgttataa gtaacatgcc tgcgatttct tgaatggcac
    12061 tttttaaagc tcgaatagga tctaaatgag cgcctcccgc acaaacaacg ttcattccat
    12121 tttcacgtgt attttttgca attacccata agctcgggat gccgtgttcc atcgtcgcat
    12181 taaaagcgtg taattcatat ccggtaatcg tacgtaaccg ctgaatcatt aattgtaatt
    12241 ctgtatcatt tgctgaactc agatcaaggc ggggaagagg taattcggca taccaagtga
    12301 gtaagaaggc atcacgctct acaatttcta aaatgccgtg aaaaatcgct tcttctaaac
    12361 taccgccaat tgcacatcca tttgatgttt catacacgaa agcatctcga tgaccgaggc
    12421 tataataagc aattgattca ggaactaaaa gcggtctgtt ttgtgataaa gaatatcccc
    12481 atacccagtt ttgctcataa tcaggatcaa acggcttaaa tggaaattta tcacgattgt
    12541 aatgttcatt tgtatgtaca ccgagtgtga ggggatttag tgcatgttcc tctaaatcat
    12601 gaaaactacc atgcacattt gtctttttcc cgcgaggtga cataccgcaa tatcgttcta
    12661 aaccttctaa aatagcagtt gcttcactca ctgcaaatga atgagttcgg cctgcaacac
    12721 cttcatttcc aaacattaat ggcatgttta taatgacgtc agcgaatggc aataaagaat
    12781 gctgcatttt gccgttcaac ataccgaccc gataatctaa atagtctcgc gttaaaaatg
    12841 tgtttaattc atgaatggaa cggcagcgat acgtttcggt gcttactttt aaactcggtt
    12901 gtaaagaaag ttccgccgca tccgcagtat catcaggtaa attactacat ataggacaga
    12961 gaggatctgg aagaaaagaa tgccgcgtac attgtaatgt ttgtaagttg agtaaaataa
    13021 gttcattttc taaagaagaa tggttatgag ttaatatttt ctctgtttct acgcgaataa
    13081 gatggcacat ttgtaacatt ccattttggg tggcgcgtac atcacgcctc gttacattgt
    13141 cggctttaaa ggcgtatttc cgctgtagtt cccacatttc ttgttgatcg aagccagcga
    13201 taaatcggcg tccatcagaa caatgagaac agccagatga aagaggatga atgtaaggac
    13261 cgataatacc ttcgccaaat gaagtgaaac cgcgaagcca cggaatatga tttgagcgaa
    13321 aaataagttc agcatcatga tgaatagtag aaggagatcc gtcatgtaat acgagagcga
    13381 ggtgaatatt ttcagggagt tcttctgtaa tggtatgttg gcgaatgatg gaatattgtt
    13441 cgcataattg atcatgtaca tagtctgcaa gtaggccatc tcctataagc aatatatttc
    13501 gagtcataga ccatcctcct ttgcaattaa taccccatac acaccgtcta agttttcttt
    13561 caaaaatggt tcgattgcta aatcaaacac gaaaggataa aaattatgtt cttctaaatg
    13621 ctgtaaggca agctgtaaag attgcacatt tggaatttct tcttctggtt gtatttccac
    13681 tctaaaagaa tcagtgtcat ataaaataat agatgagtca tacaaaatat tagctctgta
    13741 aggaatctct tcattttgaa tgtgaaagag tgccagttgt agtgcgtttc gtaacgctaa
    13801 cgtcatattt atattagatg caccgtacca tctatcattt ataccaatcc aaacgacagg
    13861 aaaactaaga atctcttcac tcattgctat tgtaggtgtt tcatggattg tagagagagc
    13921 atcgtaataa aatctacaat gcttatcgtg aatgtcagtt aaatcaattg ttgtaagttc
    13981 ttctagcgta tgtgactgcc gttcatacag tttattgttt aaatgttgtt gtagtgcgcg
    14041 gtaaaaacct tctgtcatcg tttctccagc accgataccg atatcgttat gttcaggaat
    14101 aaggcggtga atgatttctg ctacatatgt ttcaattcct gttaaaccag cttctcggcg
    14161 tgcctcatta tgggtcaatc cactgcaagt cataagaggc aggaggggag ctgggccatc
    14221 tgatagtgga ttggctactt gaatatagca ttgtgataac ggtaattgat atgaatcttg
    14281 ttcatcccat acatggaata taccggcttc tttagaagtt aatgaatcga aaaattggaa
    14341 tacatcagtt gaagtatgtt ggttagaccg atgctcaagt ttttcagaaa gattctctat
    14401 cgtatcaatt gtaaaacttt catcagttgc aagagggtgt tttataaaag gatgccacgt
    14461 tccttcgagt gtttcatagt ttaataaaaa gaattgtgat cctttttccc gatgtgaatc
    14521 atccgcgaca tgcttaaata attcaaaaac gattacattt gctaacattg cagatgtaat
    14581 gggtgagaag gaatcagatg aattttcatt ttgcaaagtc gtttcatgta gacgatgcca
    14641 tgcagattcc cagcattcat cacgattttc cgttacgaca ggtccagcta taccgagtgt
    14701 tgataaacaa atagctggta tgaaattctt tttcgcttct ctacaaatag tgtgaactgt
    14761 ctttaaaccg tcaatgtctc cattttgaga aacatataaa atccaatcaa aaggttcgaa
    14821 tacttcatgc aaaggacggt caattgtagt atcgatttct tgaaggagta cagtgttatc
    14881 aacttcatat gcacgttcta ttagctcatg tattctgtca tagtttgttt catcccgatc
    14941 tgtaacgagg taatgaaatg taggtaaacc agattctaat aaagaagaaa ctaaggaagt
    15001 aagcatatcc ccagaaccaa gtacaaggac atttgcccca cggtacgttt cgaattttaa
    15061 agcacccgaa tgagaatcag cttctaaaaa ttcaatttgt gaagcatatc tgtcgagtaa
    15121 tgtactgttt aattcatgag gttcatcttg atttgtatcg cgaacgaaac cattttcata
    15181 taaaatctct ccaatttcaa atacgcgatt ttgatagggg agagggagac catcggttat
    15241 ttctgctaaa gaataattcc cgttaaacat tggcattagt ttttcaatcc agtcataaat
    15301 tccagcaccg tccatgcgaa atgaactggc gttatttcga aaatagacac ccccgtttga
    15361 gtcggggagg aagaaagtat ccttatttac tttaagtttt gcatgaattg gaaggttatt
    15421 cattttaatc ctccttacgt ttaggcatac attattactt tatgtcatga aatttgtccc
    15481 gtatgaacaa aataaaaaaa ggctgtagaa tgattcattc tacagccttt aataggttaa
    15541 aaatctatca accttctaat aataatgatt ttggatcttc aagcatatct ttaacagcaa
    15601 caaggaagct aactgcttct ttaccatcaa caatacggtg atcgtaagat agtgcaaggt
    15661 acatcatcgg acggttttcc atacgttctg catcaattgc aactgggcgt acttgaattt
    15721 tatgcattcc taaaatacct acttgtgggc tatttaggat tggtgttgac attagagaac
    15781 cgaatacacc accgtttgta attgtaaatg taccaccttg tagttctttt aatgaaagtt
    15841 tgttatcgcg tgctttcata cctaaattac gaatttcact ttcgatttca gcgaagttta
    15901 attggttagc atcgcgtaca actggaacaa ctaatccatc tggagctgct actgcaatac
    15961 cgatatcata gaattttttg atgataagct cgtcaccttg aatttcagca tttaataatg
    16021 ggaattgttt taatgctgca acaactgctt ttgtgaagaa tgacatgaag ccaagacgta
    16081 catcatgttt tttctcgaaa gcatctttgc gttctttacg taattccatg atcgcactca
    16141 tatcaacttc gttaaatgtt gttaacattg cagatgtttg ttgaacttct acaagacgtt
    16201 ttgcaattgt ttgacggcgg cgggacattt tcacacgctc aactggtttt tcgaattcag
    16261 tttttgcaac tggagcagga gctggactct ttggagcagc tggtgcttct tttggtgctg
    16321 cagcatgagc ttgtacatca tgtggtctca cgcgtccaag tggatctgtg ctacgtacgt
    16381 cgtttaagtc gattcctaat tcacgagcca tttttctagc agctggtgat gcaataggac
    16441 ggttcgtatt tggtaagcct tgtagacccg tagtttgttc agcatttgga gctgcagctt
    16501 tcggtgcttc agctgtttct tgttttggtt gctcagcagc tggagcaggt gtacttactg
    16561 caactggtgc tccattagca tctaaaattg cgatagttgc gccaacttca actgtatccc
    16621 caggttcgcc tagtaacttc gatacaatac ctgaatcttc tgcaatgatt tctacattga
    16681 ctttatcagt ttcaagctca acaacgctgc cacctttctc aactttgtcg cctacgttga
    16741 taagccattg tgaaatagtt ccttcggtaa tagattctgc aagctcaggt actttaattt
    16801 cgatcatttt aaatgtcctc cccttatttg cctaacggtg tgttttttct tcttttgtct
    16861 tcggtaatct ccatttgtta gcctggcctt gggcagatat tctgcccaag gaacaagcta
    16921 gaaatcttca ttattacttt ttagttgctg taaacttcaa tttctagttt atcttgacgg
    16981 aagttatact tcacatctaa agcgtgtgca acaattagtt cttgctcagc tttgtgagcg
    17041 aatggatcgc cgccagatgg gctagagcga tctgggcgtc caatgtaacc cgttttcact
    17101 ttatctccag ctagttcgaa cagaattgga gccatgtaat gccatgcgcc catattacga
    17161 ggttcttctt gaacccaaat aatttcttct aagtttttaa agcgtttaat aatagattga
    17221 actttctcag cagggaatgg gtacaactgc tcaatgcgaa cgacatgaac ctcatctaag
    17281 ttgtactcat gtttaccaga ctcaatttct gctgctaagt caatcgccat tttacctgta
    17341 cttaaaacaa gacgttttac tttgtttggt tttgtgccaa ggttttcttg ttctaaagca
    17401 ggttggaaac gtccttcgct taactgacta gcagttgaaa gcgtaagtgg gtgacgtaat
    17461 aaactctttg gcgtcatcag tactaatggt cgaacagctt cggttcctaa gatagatgct
    17521 tgacgacgta aaatatggaa gtattgtgcc gcgctcgtta agtttgcaac tgtccagttg
    17581 ttctcagcag ctaactgtaa gaaacgttca ggacgtgcac tagagtgctc tggtccttga
    17641 ccttcataac cgtgtggtaa tagaagaact aaaccagatt tttgacccca ttttgctctt
    17701 ccagctgaaa catattgatc aaataatgct tgcgcagtat ttgagaagtc accatattgc
    17761 gcttcccaca taacaagagt ttctggagcg aatacgttat aaccatactc gtaaccaaca
    17821 acagcagcct ctgataacgg actgttatga acagagaatg aagcattaat gtttggtaaa
    17881 cggtgtaacg gtgaatatgt ttcatttgtt tctgtatcgt gcagtacgat atgacggtgt
    17941 gcgaatgtac cacgctgtga atcttgacca gttaaacgaa ttggcgtacc ttcttgtaaa
    18001 atagaagcga atgctaacga ttcagcaagt gcccattcaa ttttaccgtt ctcttcaaga
    18061 gcatctttac ggcgctcaag aattttcttc actttcggat atacgttaaa gccttctggc
    18121 caagataata gaccttcatt aattgcacga agtgagtcaa gctcaacacc agtatcaatt
    18181 ggctgaatac cttttgcaac aacatctggc actttaacgt gaattgttgc atcgctcgta
    18241 tcagctagtg gtacttgtgc atagtcggat tttaattgct cttgtataaa ctgtgtaatt
    18301 gtttcaattt catctgcatt tagaacacca gcagcttgta attgctctgc gtaaattgct
    18361 cttacagtag ggtggttttt aatttttttg tacacttgtg gttgcgtaac cgctgggtca
    18421 tccatttcgt tatgaccgta gcgacggtaa ccaattaaat cgattaagaa gtcttttttg
    18481 aacaacatgc gatattgaat cgcaaggtta gcagctgcaa gacaagcttc tggatcatca
    18541 gcgttcacgt gaacaatcgg aatatcgaaa ccttttgcaa ggtcacttga atatttcgta
    18601 gaacgagaat catagctatc agtcgtaaaa ccaactgcat tgtttgcgat aacatgaatc
    18661 gttccgcctg tttgatacgc gttcaatctg cttaagttga gtgtctcaga tacaatacct
    18721 tgaccaggga atgcagcatc accatgaact aaaattacga atgattttga agtatcttga
    18781 tctggaagac cagatttttt acgattctct tgagcagcac gtgcgaaacc ttctactacg
    18841 ggattcacga actcaagatg actcgggtta tttgctaatg tcacgcgagt gctaacttct
    18901 tcgttactca cgacttgttc tctacctagg tggtatttta cgtcgccagt ccagccagaa
    18961 ttggctactg cgccttctat ttttgcatgt ttgaactcag caaacatgtg actatatggt
    19021 ttttctaata cgtgagcaag tacgcttaga cgaccgcggt gagccatacc aatcatgaca
    19081 tcctctacgc cgttcttagc accttctaga acaatttcat ctaaaacagg tacaagcata
    19141 tcaacgccct cgatagagaa acgtttttgc ccaacgaatg ttttatgcaa gaattgctcg
    19201 aaaccttcaa cagctgttaa acgttttaaa agagcagttc gttttttatt tgatagtggt
    19261 tgacgcaatg aatttgattc caccatttga tgcaaccacg cgcgttcttc actatcttgt
    19321 atatgagaaa attcataagc taaagatttt gtataaacgt cttttaatct atgaattaca
    19381 tcaagtgcag tgtgaatacc ttctggtgca tcttgccata ctgttttcgc tggaatcgct
    19441 ttcaagtcag cgtcgctcag ttcactcatt gctttttcaa gaagtgattg tccatttgca
    19501 gcatcttcca tcgggttgat gtgagccaac gtgtgcccga aagaacgaat ctgctcaaca
    19561 agttgaacga ctttaagaat tttttcaatg ttacctgtgt tttgaggaga aaaatgtgtt
    19621 gctgtgttgt cccctgttac gacatcatct tgaaacgaag gagctccaaa aatttcaaaa
    19681 agctcttgta attccggatc aacagaacct gctccagtta cgtaaagatc atactgctca
    19741 ataacataac caaggttcgg accgtggaac ttggcccaag ggtttgtcgt tgtattcttc
    19801 ctcgtcattt gtttaaacct cccaatgcat ataatccttt tccatacaaa ggtgcatttt
    19861 gctctttttc aattaagtaa tgaatcaata atcaatgtaa atgttttctt tactcttatg
    19921 ttattacaat aatttacata ataccaaaca ctattactta tctgttttgt aaaaaaacat
    19981 tcacaataac ttatcaccca agttaatctt tcatgttata aagtaatttt acagaaaaat
    20041 ggggtggata tatttggtat acctacatta aaaactagaa ttgttacatg taaatataag
    20101 tataatcgtt ggaatgtttt gataaaagtt gattagaatt atgtatattg aaataataag
    20161 cgctttcata gatattatac aacaatataa cggaatatag tataaaaaat aaaaaattat
    20221 gaatttagcg taaactttat ttcgatagtg ttaactatcg aaaggaaaat gaaggatttc
    20281 cacaaaaaaa gtggctaaac ataaaaattg cttcataacc cgttagtttc tataaatatg
    20341 ccaaaaaaca ccgtaaaacc aataacgcat ttcatctaat aaagaagaga atgaaatatt
    20401 ttaaaaggat aaaacaaata tgaagatatt aaattttaaa aaaggtgagg aggaaatata
    20461 gtaacgatta catacagtgt tccaggtttt attacaaaat agacgtgttg aaatcgaaca
    20521 agtttcttct atataaatag agtgaaaaat gattaaaagg aatgtaaagg aaacttgacg
    20581 taaagtttac tttacatata tactcgatat atgggaggag ggagaaattt ccttggaaaa
    20641 taaaatggtc gaataccgaa aaaaatttgg actatctcaa gaaaaattag ctgagaaact
    20701 tggcgtttca agacaaacca ttatctcaat tgaaaaagga aaatacgatc cgtcacttcc
    20761 gttagcattt gaaatagcaa aaacatttca aacaacgata gaacatgtat ttatttatga
    20821 aggaaaagaa gagggggaat agggatgaat tattcacaaa agtactttgt aattatgggt
    20881 gttatttttc tatttatgag tggatttatg atattaacag gtataatgac gcattctgca
    20941 ccaccagcta taacgtatcc attgcttggg atgatgatta tgagtttctg cctaagctac
    21001 ttgcatccgc aatttaaaga aaaagacgag cgaatgaaac ttattcgtta taaaggaatg
    21061 tttgtaacct tttttgcatt aacagcatat tatcttcttt tctctatcgg cttaaactta
    21121 aaaatactta cactatctgc tactgaatta ttgaatatac ttatggcact tacaatgagt
    21181 accgtcttta tctcatttgt tgttttggca aaaagatatt aagatggaag agagaaagga
    21241 agattaatat atgcaaatga tgtatgcttt tggcattggg cttgtattat ttttagctgt
    21301 attcttattt attcgtaaag acgttcaagg cgggacgtta acgaaacgag gattttataa
    21361 aatgatcggc tgtttagttg ttatgtttat tgcgattatt gtaatgattg ttttaataag
    21421 tcggtcacta tagaatgtaa aaaaggaacc ttacttcggt aaggtttttc tttattgttc
    21481 aacctgaaaa ttaccgctaa atccatttat tataaataac ttatattata taatccaatg
    21541 aaatgataga taaggagtgt agtatatgaa taaaaaacta tcttctattt attaacttgt
    21601 ctactacttg tagctagtac tgcttattat aatatgtaac aaacgagaac aagtgccacc
    21661 tatattagta tgtgaggatc aggagtacca cgtaacgaat gaacctgcca aagtagaaga
    21721 agttgggcaa aaacttggtg aagtaacaaa aaaaattaaa acaagtaaaa aacctattaa
    21781 aaatagagaa tctaatacat tacaagagaa aacagaagta ttcacaatga ttgaggaaga
    21841 aaaagatcct caatcacctt taatcataaa ggaaacttat agtgatgaat atagggtagt
    21901 gaggccgatg ttgaagcagg tattgtgatg aaaaggagaa tcttttgtag acagtaattt
    21961 cgtatccgtg ggtgttaaga aaaacttttt tcctttgttt tattttgtcc cctatcggtg
    22021 ccgcttgcat tttgatgaat agaggagcaa tacaaaagag agatttcatt ttatatttat
    22081 tatttgctgc tatgaatata tcactttggt tattgcttat gatttttgat tggagtatgt
    22141 ggatggtagt agggcattat ttgtttggag cagttgttat tgttttttcg aatatgaata
    22201 agagctaagc cagcaacctt aaagttgctg gtttttattt tgctatttat aatgaagaaa
    22261 caaataaatc aatatgtaaa gaaggaatgg tatagataaa agtaacgcct gaacggttag
    22321 aacagactgc aaagacagta aataacatca ggcacttctt agaatactta cataatgact
    22381 tatacaatca aattaagaat atcgctatac aatggaatgg agcgagtaga gaacaatttt
    22441 aacagagatt taacgaagta aaaccaaaaa tgtttaatgt tttaatagaa gttaaaaact
    22501 acaatgttta ttaatgaaat ctagtggtag actttcatta ataaacattg tagtaaaaca
    22561 gttggaagat agattgaaat atttgcccga aggttcacat cagactgtcg tgatagatgt
    22621 gagaggacca gatggaacga gagaaacatt gaagtaaata agagaagaaa taaatcaaag
    22681 aacatttgga caggcagaaa ttatcattaa aaagatacaa aaaagtaggt tatattacag
    22741 agttagcaca aatgcataag ttataatttc aagtgccata aggataaccc tgaggagaaa
    22801 aaagacttct gatttttaag attatataaa atattcatag ttgcaaaaac tctattgtgg
    22861 taaaatattc tatataaata tttaaaaggg gaatggctat gggggatata aaagttactc
    22921 ctgaacagtt gcgaaaagtg gcagggacta ttagatcaac tatcacgaat gcaactgcaa
    22981 cacaggagcg actaaaacga gatattgata tgatttctag taattggttg ggctcaacct
    23041 atatgaaatt taatacggat ttccgtgatt catcctttaa gatggcacaa tttataatca
    23101 tattggagcc acttgagaag tttcttcttg attctgctaa taaatttgaa caagtagata
    23161 acatggatgt tgctattgcg ttggcttcca gtattttaac tgggaaacct tttaaagggg
    23221 attacgaaac tttaacaggt gattttaaat tagcagaagg aaatcgagtg ggaatgaaag
    23281 cagaaggttc attgataaaa ggtgaatatg agatttcgaa aggaacaaag cttactttta
    23341 aagggggaaa tggctcctta gagaccagtg ttccaatgga tgaaaagaca tttattagtg
    23401 atgttgcagg aggggggtta gtaggcttta aagttggtgc ttctcttttt gaggactcaa
    23461 tagaaaaaga aataaatagc ggttttgcag aaaaagcaac agttaca
//
