LOCUS       NZ_JTKO01000015        28219 bp    DNA     linear   CON 11-APR-2024
DEFINITION  Staphylococcus pseudintermedius strain 2001-08-299-1 contig_15,
            whole genome shotgun sequence.
ACCESSION   NZ_JTKO01000015
VERSION     NZ_JTKO01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Staphylococcus pseudintermedius
  ORGANISM  Staphylococcus pseudintermedius
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus; Staphylococcus intermedius group.
REFERENCE   1  (bases 1 to 44807)
  AUTHORS   de Vries,L.E., Hasman,H., Jurado Rabadan,S. and Agerso,Y.
  TITLE     Sequence-Based Characterization of Tn5801-Like Genomic Islands in
            Tetracycline-Resistant Staphylococcus pseudintermedius and Other
            Gram-positive Bacteria from Humans and Animals
  JOURNAL   Front Microbiol 7, 576 (2016)
   PUBMED   27199912
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44807)
  AUTHORS   de Vries,L.E. and Agersoe,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-DEC-2014) Department of Technology, University College
            Metropolitan, Sigurdsgade 26, Copenhagen 2200, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: SEP-2014
            Assembly Method                   :: CLC NGS Cell v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 20.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001622945.1-RS_2024_04_11
            Annotation Date                   :: 04/11/2024 12:27:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,368
            CDSs (total)                      :: 2,296
            Genes (coding)                    :: 2,259
            CDSs (with protein)               :: 2,259
            Genes (RNA)                       :: 72
            rRNAs                             :: 5, 2, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 13 of 37
            Pseudo Genes (incomplete)         :: 26 of 37
            Pseudo Genes (internal stop)      :: 7 of 37
            Pseudo Genes (multiple problems)  :: 9 of 37
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:20:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 16588
            Orig. end                         :: 44807
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JTKO01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..28219
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="CDPS"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="CDPS"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..28219
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="CDPS"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="CDPS"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20708
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20708
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10708](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10708
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            243..899
                     /gene="tsaB"
                     /locus_tag="NO87_RS11415"
                     /old_locus_tag="NO87_11415"
     CDS             243..899
                     /EC_number="2.3.1.234"
                     /GO_function="GO:0003725 - double-stranded RNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015729420.1"
                     /locus_tag="NO87_RS11415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11415"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="WP_014613397.1"
                     /transl_table=11
                     /translation="MYSLLIDSANQPLSVAIMQEGHVLITHTTTIKRNHSVQLMPLIEW
                     LLQQAQLKPKDLDEIIVTEGPGSYTGLRIGVTTAKTLAYTLNIRLYGVSSLKAIAAQIQ
                     YSDAYIIPVINARRQHVYAGVYQWQQGELVNVMVDQYTPLDRLIEQWTTNDNVIFVGED
                     VAQFETELAPFKRLSAPPRADQMYPHKGAPRDIHTFTPQYLKLSEAEQNWLNQQK"
     gene            878..1348
                     /gene="rimI"
                     /locus_tag="NO87_RS11420"
                     /old_locus_tag="NO87_11420"
     CDS             878..1348
                     /EC_number="2.3.1.266"
                     /GO_function="GO:0008999 -
                     peptide-alanine-alpha-N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rimI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613398.1"
                     /locus_tag="NO87_RS11420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11420"
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="WP_014613398.1"
                     /transl_table=11
                     /translation="MAESTKIEDQLQIRRMSHEDVPEVFDLEQASFQHSSWTIDAFYYE
                     LEQNNFAHYFVLEYDQRIIGYLGLWVVVDQAQVTTIAIDAAYQGHGLGQMLLKYGMNYV
                     GSIATVMSLEVRVDNVVAQHVYRKLGFQFGGKRKNYYGDGEDALVMWVNLYE"
     gene            1341..2363
                     /gene="tsaD"
                     /locus_tag="NO87_RS11425"
                     /old_locus_tag="NO87_11425"
     CDS             1341..2363
                     /EC_number="2.3.1.234"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613399.1"
                     /locus_tag="NO87_RS11425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11425"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="WP_063284999.1"
                     /transl_table=11
                     /translation="MNEQTKILALETSCDETSVSVIENGQTILSNSVLSQIESHQRFGG
                     VVPEVASRHHVENITVMIEEALQQAHTSIEDVDAVAVTQGPGLIGALLVGVNAAKALAF
                     ANDKPLIPVHHIAGHVYANQLQSGLKFPLIALIVSGGHTELVYMENHLQFEVIGETRDD
                     AVGEAYDKVARKIGLPYPGGPAIDRLATQGEDTYDFPRVWLEPDSYDFSFSGLKSAVIN
                     KLHQLEQKGDPIIPENVATSFQNSVVEVLVGKAMRACEAYGVKQLIVAGGVASNRGLRH
                     ALEVATAEKGIELAIPEPKLCTDNAAMIGAAAHEIYLKGIRGDMALNGQSSMDIEMYRD
                     "
     gene            complement(2590..>2808)
                     /locus_tag="NO87_RS11905"
                     /pseudo=""
     CDS             complement(2590..>2808)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495236.1"
                     /locus_tag="NO87_RS11905"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS110 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KARRLLYLIIMNIIRGRNHYQSHIVDYYYKLREQPHGKTHKTAVI
                     ASINRLLKTIHYLIVNNKLYDYQKAPH"
     gene            complement(3337..4920)
                     /locus_tag="NO87_RS11430"
                     /old_locus_tag="NO87_11430"
     CDS             complement(3337..4920)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613401.1"
                     /locus_tag="NO87_RS11430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11430"
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="WP_063285000.1"
                     /transl_table=11
                     /translation="MSSNTFFILLLVVALVGMTLITETVRRIRHQRMLTYHLEHFTRFD
                     TTENPHAVYDAYFNSRHTARNTIIDDKTWSDLSMDLLFDKLNATYTSIGENHLYSALRL
                     QTSLVHYEFLEQLRPYPNQHREIVKRLVDLGKSIYPNYDKDILKQQYQWIYAFLLAMPF
                     VGLMISFFNLGIGLLWICFAFFLNIIISFRYNYYVEKDLKQLFIMGRVVRETEILSKMT
                     ITPEFNHSLKPLSSISRLRFLLINVETIPGYFVMVFKYMFLVDIHLYATLVRRFIKHYD
                     TVLECYRYIGELDSLLAVYQYRCHYDTSEPVEADHVTFEGLTHPLIDEAVPNDFDFNQN
                     VLITGSNASGKSTFMKAVALNLIMAQAIRTVTADKFHYTPGMVKTTMANADDVTSGDSY
                     FMAELKSLKRLFLQDAAVQHYYFIDEIFKGTNTTERVAASHAVLDYLNKLSHLKIIAAT
                     HDIELTEVLAHQYANYHFNEHVTDGEIVFDYHIKEGPANTRNALELIRIMQFPNRIYTD
                     AQAYVKQLET"
     gene            complement(5283..7235)
                     /locus_tag="NO87_RS11435"
                     /old_locus_tag="NO87_11435"
     CDS             complement(5283..7235)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015729418.1"
                     /locus_tag="NO87_RS11435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11435"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_063285001.1"
                     /transl_table=11
                     /translation="MILMQLSQITKSFDGEEIFEGVNFEVKTGERIGIVGRNGAGKSTL
                     MKIIAGVESYDSGHISKIKGLKLGYLTQQMTLNTENTVFEEMAKPFEQVKAIGKRMQEE
                     TDWLAAHAEAYETTEYQTHIAKYEQLSNEFEQLGGYHYDSKIKTVLNGLDFSEADYDRP
                     INDFSGGQKTRLSLAQMLLSEPDLLLLDEPTNHLDMATTEWLEDYLKYFKGAIVIISHD
                     RFFLDKIVTQIYDVSLGEVKHYVGNYAKFIQLRDQYFQKRLAEYERQQSEIKRLETFVE
                     KNITRASTSGMAKSRRKMLEKMTRIEKPMLDARSANIQFDFDRNTGNDVMHIQDLEIGY
                     RTPITAPIRFEINKGDHIGIIGPNGIGKSTLIKTLAKRLPPLSGQIIEGANLKIGYYDQ
                     KQAEFRSNKTILDFVWDQYPHMPEKDVRAVLGRFLFTQDEVLKVINDLSGGEKARLQLA
                     LLMLERNNVLILDEPTNHLDIDSKEMLEQALKNFEGTLIFVSHDRYFINELANRIFDLN
                     KTGGHLYLGDYQYYLEKLEQQNALAAYDEQREDNNTSDDSARSQNTYQDQKALRREKRK
                     IERQIEADEQKITELEARIAAIDVAMTDDTTMNDYEKTQALANERTSIEQSLEQVMTNW
                     EELQLTLSQFEDEMD"
     misc_feature    complement(7342..7357)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            7389..8036
                     /locus_tag="NO87_RS11440"
                     /old_locus_tag="NO87_11440"
     CDS             7389..8036
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613403.1"
                     /locus_tag="NO87_RS11440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11440"
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="WP_063285002.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 3.4e-09, bitscore:
                     28.9, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKSMNKIPRATLKRLPLYYRFVNTLKAKGEDRVNSKAISEGLNI
                     DSATIRRDFSYFGELGKKGYGYNIDSLLEFFKSELSDSDIIKIGIVGVGHLGTALISYN
                     FSIHDDMTITEAFDIREDIIGTTVGDITIKPMDDIKETIASGELEVVIITTPESAAQAV
                     TDQLVEAGIKGILNFTPKRVHAPQSVQVHQIDLGIELQSLLFFMKNYGTSEA"
     gene            complement(8202..9386)
                     /locus_tag="NO87_RS11445"
                     /old_locus_tag="NO87_11445"
     CDS             complement(8202..9386)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613404.1"
                     /locus_tag="NO87_RS11445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11445"
                     /product="MFS transporter"
                     /protein_id="WP_063285010.1"
                     /transl_table=11
                     /translation="MIQTKHDFNLYILCFLAFFASLIQNIYTPIIPKLHDSFQVSLFWI
                     NFTVGGFIFIVAIMQILLGKNIDSKNSKRTLLVGLGIVIISSFICSITNNFIIFVVSRL
                     LQAIGCGIIPLVTLTLLAQLTTNNERASVMANYQIFLSCAPALAPILGSVLGAKWNYFG
                     IFVFLLVVSILLFIVLYLIDIPDAIKAVAQSNVDLSGKNYLTDKVFITLVFLGFLVFFT
                     YFSILVYLPILLSNSYSIAPIMIGILFLPITTSVIIGSIVYKKISKVKDSMTILRNTVI
                     TFAIFTLSFGLMHYLNLIVLSLIIFALGFLVGIVPALLSTLISQRYENIKGKVLGIFNF
                     IRYLGMTFGSITIGLISQQYMLFYFSFIFIVMLTIFLYIKTVHFNQAMTDFYHL"
     cand_cluster    8426..28219
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    8426..28219
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[18425:19131](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(18426..19131)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     gene            complement(9367..9846)
                     /locus_tag="NO87_RS11450"
                     /old_locus_tag="NO87_11450"
     CDS             complement(9367..9846)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613405.1"
                     /locus_tag="NO87_RS11450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11450"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_014613405.1"
                     /transl_table=11
                     /translation="MNKQQKVIITLQQFIIERENANKRRKNIKGDEGLNLSLTQFHIIE
                     LIANNDKVNNKFLADKLNISNPAVTKSIKKLLSKDLVLELQNAQNKREVHYKLTKKGKK
                     LSSIHDELHNQAVKKYEEVLKVFNEKELDVIVEFLSRSISALKEEEVDYDDSNKT"
     gene            10001..10708
                     /locus_tag="NO87_RS11455"
                     /old_locus_tag="NO87_11455"
     CDS             10001..10708
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276926.1"
                     /locus_tag="NO87_RS11455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11455"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_037542576.1"
                     /sec_met_domain="CDPS (E-value: 1.1e-58, bitscore: 189.9,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQQFKVDFLTENCKKIYQRKKHVILGISPFTSKYNETYIRKLIQ
                     WANTNFKDFSILLAGEESKNLLECLGYSTTKANRKVRKEVNRQIRFCENELLNCNRTIN
                     DRIFRFSDFKQNTYYVNMYQKIEGLFNTDDSFKKCCLNMSLQALQSKKNNLNSTIEFTN
                     DMLEYSAQYVLAELPFFLNANPIINTYETLMAYHAEWELGTNIINNMFDLKMDSHQGYI
                     ILTDRGDNYVKTI"
     gene            10692..11892
                     /locus_tag="NO87_RS11460"
                     /old_locus_tag="NO87_11460"
                     /pseudo=""
     CDS             10692..11892
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613407.1"
                     /locus_tag="NO87_RS11460"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11460"
                     /product="cytochrome P450, cyclodipeptide
                     synthase-associated"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLKQSKSIFDEAYEINPIPYFNYFREYAPIHYEESVNAYFVSNYE
                     DVKFILKSDGIFTTKTLAERAEPVMKDRVLAQMTGHEHRSKKKEILKGMSGKYLDRLLP
                     TIEKRTNNLIDKYINEKRIDLVNDFGKIFAVQSSMDLLGIDIRDSDKIREWHNGIAKFI
                     TSFNMSSEDVKYSLSCSDKLEKYLMPLIKERKGIKKTRLNFCFK"
     gene            complement(<12435..12549)
                     /locus_tag="NO87_RS12045"
                     /pseudo=""
     CDS             complement(<12435..12549)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029204.1"
                     /locus_tag="NO87_RS12045"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="ribose transporter RbsU"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNMVALLIGLGPLLDWIFSYNRIKIWR"
     misc_feature    complement(12603..12617)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 25.01"
                     /tool="antismash"
     gene            12886..13833
                     /locus_tag="NO87_RS11465"
                     /old_locus_tag="NO87_11465"
     CDS             12886..13833
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613408.1"
                     /locus_tag="NO87_RS11465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11465"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_014613408.1"
                     /transl_table=11
                     /translation="MNIQDIANLAGVSKSTVSRYLNQGSISLKTKRKIQHVIDTYGYEP
                     NQFAQSLRAQKSMMIGIIFPRMYSHAVSQTVKGIKAKCDAFGYQMLLNLTERHVEQELD
                     ALKSFKRSKVDGILFMATTVTDAHMAVIQEIDKPVIIIGQAHASLSSVYHNDYQAGQLM
                     GREIMAQGKQHVIYASIQEDDVAVGEQRFRGLIEVLTANQVTYETLMTSFDYETALQSI
                     KGQLTQQPSVAYVGATDTIALALYQALMHDHMTEPPWIAGFGGDPMTQIVHPTIFTLPY
                     QYEAAGRIAFEQLQLQMEQPDLIQSCQLDVNSKL"
     gene            13889..15373
                     /locus_tag="NO87_RS11470"
                     /old_locus_tag="NO87_11470"
     CDS             13889..15373
                     /EC_number="3.2.1.26"
                     /GO_function="GO:0004564 - beta-fructofuranosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613409.1"
                     /locus_tag="NO87_RS11470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11470"
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="WP_063285003.1"
                     /transl_table=11
                     /translation="MEQWSREKRYRKYEEATHEELELLTAKVNRSPFRQTYHIQPPTGL
                     LNDPNGLIFFNGQYYIAHQWFPLGAVHGLKYWRLLTSNNLVQFEDRGVVLRPDQTFDSH
                     GVYSGSAFSFHQKLYYMYTGNHRDNEWNRHSSQIVAEVQANGSVRKLLPPAIPAPPQGY
                     TQHFRDPKVFEKDGKLYALLGAQRENETGCAVLYEAERPEGPWQFKGEIQTQLEDFGYM
                     WECPDYFQIHGKDILLFCPQGIESEGDAYQNIYQSGYIMGTLNFDTLEFDHGPFIELDH
                     GFDFYAPQTMTDEAGRRVLIGWMGLPDTEYPTDDDGWAHCLTLPRTLTIEDGKLKQKPH
                     MHLRKLRKNEEVALGYANKFIKQLHPYEGVQYELVVDILENEASAFELQLRASRNESTT
                     IRYDATTRQVSLERFDSGALPYPVEGTMRVTQLHTDLKQLRIFVDTSSIEIFCNEGERV
                     LTSRIFPKATSNKFKVVTDSGQIYLKMTKYDIVEGG"
     gene            15377..16321
                     /locus_tag="NO87_RS11475"
                     /old_locus_tag="NO87_11475"
     CDS             15377..16321
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166402.1"
                     /locus_tag="NO87_RS11475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11475"
                     /product="carbohydrate kinase"
                     /protein_id="WP_063285004.1"
                     /transl_table=11
                     /translation="MKRFYAIGEALIDFIPTQRETSLKDVTGFEPQVGGAPCNVAAAVQ
                     KLGGNSHLITQVGEDAFGDKIIETLQAVEVDISHILTTKEANTALAFVSLSNDGERDFS
                     FYRKPSADMLYEAENIDTIELQQGDLVHFCSVALVDSPMKRAHVKLLDKAEQVGATVVF
                     DPNVRLPLWDDHDVYYETLQAFLPRAHVVKVSDEELSFVTRHEDEAEALKSLFVGNVQA
                     VIYTKGSRGASLIFEDGSTIEVPTPPAQVVDSTGAGDAFIGAISAKLCQSEQQPIETLR
                     QHGHDILKFAHQVSGRVVSQYGAISSLPTLEEL"
     gene            complement(16381..17097)
                     /locus_tag="NO87_RS11480"
                     /old_locus_tag="NO87_11480"
     CDS             complement(16381..17097)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688500.1"
                     /locus_tag="NO87_RS11480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11480"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_014613411.1"
                     /transl_table=11
                     /translation="MKILICEDDPKQRERMVSIIENYIMIEEKPMKIELATNDPYAILE
                     TSKNMTDIGCYFLDIQLESDINGIKLGSEIRKHDPVGNIIFVTSHSELTYLTFVYKVAA
                     MDFIFKDDPEELRTRIIDCLETALKRLDLLTKDHTVETLELKRGTSSVYVNYDDVMFFE
                     SSPKSHRLIAHLDNRQIEFYGNLKELAQLDDRFFRCHNSYVLNRRNITSVDTKERIAYF
                     KNEEFCYVSVRNLKKI"
     gene            complement(17111..17974)
                     /locus_tag="NO87_RS11485"
                     /old_locus_tag="NO87_11485"
     CDS             complement(17111..17974)
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="NO87_RS11485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11485"
                     /product="sensor histidine kinase"
                     /protein_id="WP_233276610.1"
                     /transl_table=11
                     /translation="MNKFYLAMLVLFLASGFIIFSSILPKTVNNVYDFKYLGIIYFISF
                     SVFAILIIATTLTIEREINYKRKKQELDDYYKYTVQIEKINNKMRKFRHDYTNILLTMS
                     EYLREDDLEGLKQYYHEHISPLKSEFESNTMRLNGIENLKVREIKGLITTKILQAQENN
                     IEITVEVADEITQIDMDAIQLSRVLGIIMDNAIEASNTIEDPIIQIAFIKTDASVMIII
                     MNKAPKDMPKLHTLFQDGFSTKGNNRGIGLTTLKEIIDQTDNVFLDTTIENHYFIQKLE
                     IMNDYE"
     misc_feature    complement(18365..18381)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.06"
                     /tool="antismash"
     gene            complement(18426..18563)
                     /locus_tag="NO87_RS11490"
                     /old_locus_tag="NO87_11490"
     CDS             complement(18426..18563)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613413.1"
                     /locus_tag="NO87_RS11490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11490"
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_020219911.1"
                     /sec_met_domain="TIGR04223 (E-value: 5.9e-11, bitscore:
                     33.8, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILEVLFNLITNLFQSIGTFAKYPTSTGFFDEPEIPAELLEEDK
                     "
     gene            complement(18565..19131)
                     /locus_tag="NO87_RS11495"
                     /old_locus_tag="NO87_11495"
     CDS             complement(18565..19131)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613414.1"
                     /locus_tag="NO87_RS11495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11495"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_020219910.1"
                     /sec_met_domain="AgrB (E-value: 8.4e-33, bitscore: 104.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLIDNGIEKMALKLQQRQNLSHIEFLKVRLGMQVVVINSFKAVV
                     TYGLALLLNIFLYTLIVHLTFLALRGYSHGAHAKTSMLCHVQNIASFVVLPWLIVQYDI
                     SFQFLLSLSILAAMIVIKYAPAATKKRPIAPRRVKGLKIKSIIVFILLMTLAFFVPTPY
                     NRFVVYGVLLQSFTLLPIFYTKEEV"
     gene            complement(19888..20691)
                     /locus_tag="NO87_RS11500"
                     /old_locus_tag="NO87_11500"
     CDS             complement(19888..20691)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166407.1"
                     /locus_tag="NO87_RS11500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11500"
                     /product="carbon-nitrogen family hydrolase"
                     /protein_id="WP_063285006.1"
                     /transl_table=11
                     /translation="MQIQLFQINVAIANSRQNEQKITTLFEQHLDDQTDVVVLPEMWNN
                     GYALPQLDKLADEDLAQSYAFIQKLAQNYQVDIVAGSVSNRKEGAVYNTAFAVNRRGEK
                     IYEYDKIHLVPMLDEPDFLTCGKSVPYPYSLSDGTSVSQIICYDLRFPELSRYPAAQGA
                     KVMFYVAQWPEVRLTHWRQLLQARAVENDMYVVAVNGSGHDGKTTYAGHSMVVDPNGEI
                     IAEADENETVMTVTLDLQKVDTQRRAIPVFENMRPSVYRYAQKEI"
     gene            20856..22217
                     /locus_tag="NO87_RS11505"
                     /old_locus_tag="NO87_11505"
     CDS             20856..22217
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014613417.1"
                     /locus_tag="NO87_RS11505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11505"
                     /product="SdrH family protein"
                     /protein_id="WP_063285007.1"
                     /transl_table=11
                     /translation="MVEYKKEHSVKRLLKLGIGSTSILCVVSPLLLTHDVVQAADINNR
                     MPALNTLKTTSSYDQRAHMDELRSAITSDSDTTQTPSFNEITVSSTNETDAASTENVNP
                     SDEVPAKDESESTAPSTEQDTSIEEPGTEEVPSHEDNHHNTPSQEEQPSPPVQPGTNKD
                     EESGEKPNKENHRKPNQPNKDQPSKDENKKPDKGNKPAPPSKAPNRPDQKEDGSNNTPP
                     PATDNGGNSNDGTTTGPNGGGGSEASPPPNEQPSNGNASDTHQNGSVSSTNHSNQYGTS
                     AYDEYAGLLNNNYKYNPLFKEEVARLSQFGSQDQHDIASLSRKEQFSQNAFLDDLQQST
                     DYFRYQYFNPLSTEQYYHRLDKQVLALVTGEFGSMPDFKKSGDKSLVNKHQQDKVKKIE
                     QQGENINTHHMKNTKEDTGKSLSYKPMIYIGIVMVGFVGLISMILWKRLHHFWK"
     gene            complement(22329..23096)
                     /locus_tag="NO87_RS11510"
                     /old_locus_tag="NO87_11510"
     CDS             complement(22329..23096)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019166409.1"
                     /locus_tag="NO87_RS11510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11510"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_063278583.1"
                     /sec_met_domain="Abi (E-value: 7.5e-18, bitscore: 56.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRFWVSLLTVVLYILAQISPYIARAVGWIQTGNQAQLLRQSIAV
                     QFTAFIIVAILIIILQLFVKNKLNFELGPKEKKRYVLPYILVGLVIVFIAQMVVNLISV
                     QLFGANPASENTLRIMKIARQMPIFIVLIAIVGPLLEEFVFRKVLFGELYHAIKANQWV
                     KFTIATTISSAVFAVVHMDFSHFLAYFVMGIIFSAFYIYTKRLSVSIGIHMAQNGLVAL
                     IQLMMPEKMIEEAVKQTQFILLLTSHWMSFFLS"
     gene            23266..23553
                     /gene="groES"
                     /locus_tag="NO87_RS11515"
                     /old_locus_tag="NO87_11515"
     CDS             23266..23553
                     /codon_start=1
                     /gene="groES"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011275309.1"
                     /locus_tag="NO87_RS11515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11515"
                     /product="co-chaperone GroES"
                     /protein_id="WP_015729412.1"
                     /transl_table=11
                     /translation="MLRPLGNRVVIEKKEHEQTTKSGIVLTDSAKEKSNEGVIVAVGPG
                     RILDNGERLKPELNEGDRVVFQQYAGTEVKRDDKEYLVLTEDEVLAVIED"
     gene            23602..25221
                     /gene="groL"
                     /locus_tag="NO87_RS11520"
                     /old_locus_tag="NO87_11520"
     CDS             23602..25221
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /gene="groL"
                     /gene_functions="other (smcogs) SMCOG1299: chaperonin
                     GroEL"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500736.1"
                     /locus_tag="NO87_RS11520"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11520"
                     /product="chaperonin GroEL"
                     /protein_id="WP_014613420.1"
                     /transl_table=11
                     /translation="MAKELKFSEDARQAMLRGVDKLANAVKVTIGPKGRNVVLDKEFTA
                     PLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLK
                     NVTSGANPVGIRQGIDKAVAVAIESLHNISQKVENKEEIAQVGAISAADEEVGRYISEA
                     MEKVGNDGVISIEESNGFNTELEVVEGMQFDRGYQSPYMVTDSDKMIAELERPYILITD
                     KKISSFQDILPLLEQIVQSNRPILIVADEVEGDALTNLVLNRMRGTFTAVAVKAPGFGD
                     RRKAMLEDLAIVTGAQVITDDLGLELKEATLDMLGTANKVEVTKDNTTVVDGDGDTANI
                     DARVGQLKAQIEETDSDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALN
                     STRAAVEEGIVAGGGTALMNIFKDVQAIEAEGDEATGVNIVLKALQAPVRQIAENAGLE
                     GSVIVERMKNAEPGIGYNAATDEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAV
                     VANIPEDKGNDMPQMGGMPGMM"
     gene            25502..25645
                     /locus_tag="NO87_RS12410"
     CDS             25502..25645
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013828.4"
                     /locus_tag="NO87_RS12410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_226957587.1"
                     /transl_table=11
                     /translation="MKYLTVFNFTFQSSINKQEIFTLKSMHFQEKSINIYFIGNSGGHN
                     NF"
     gene            <25888..26517
                     /locus_tag="NO87_RS12415"
                     /pseudo=""
     CDS             <25888..26517
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000708297.1"
                     /locus_tag="NO87_RS12415"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="SAR2788 family putative toxin"
                     /pseudo=""
                     /transl_table=11
                     /translation="NKNIKNTKISEDKNGEVSRLSTSINNRELDLDTVLTNDFKTGDIN
                     LSGEISNIEESKQVDYTIDLTYADEKDIAGFLIDNLTGEEHEFDTRLAEASAAPIVVVA
                     VMAARYGIQWTIKKYGKKAVSNAIKSNTHKVAKGINSSPLTSKGVDIGKFTQKVRGKNP
                     VYRDPKTGWSISKNKGQPHGGSYWKLLDKGGTRKATLTKDGKILRK"
     gene            26532..27137
                     /locus_tag="NO87_RS11530"
                     /old_locus_tag="NO87_11530"
     CDS             26532..27137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000368755.1"
                     /locus_tag="NO87_RS11530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11530"
                     /product="DUF3885 domain-containing protein"
                     /protein_id="WP_015729409.1"
                     /transl_table=11
                     /translation="MSNIISCMEVSGLKFSEGENAVHLDLSEGEYPFLDDGKSFNKDYF
                     ARIHNNAIQILQDLFQQSNTIDIVLLYYLYGDSFKKTRFKEKFSYFNNNEIPDFKEYIN
                     DEGIQCYIFSYKNKNLKDLNYKKLVRAISNQDFKGLFPTINQKDNYLDIYLMDSKRGIL
                     FHLYDDRGLWLYFLNKQSYKIYSQKYSNLLFDVSHEMD"
     gene            27124..27825
                     /locus_tag="NO87_RS11535"
                     /old_locus_tag="NO87_11535"
     CDS             27124..27825
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015729408.1"
                     /locus_tag="NO87_RS11535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NO87_11535"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_063285008.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.8e-16, bitscore:
                     51.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWIKVYLKLIILILLSIFIYLNYNCKYEKSKIAVLDTGVEKKAI
                     KSKVISRNFTLDNNSNSVHANKVSKIIEYEADIVIYDAKVLNHHGNGRLEDTISALDWA
                     IKNNVDIINMSYGFTKNYPELHRKIKEAHEKGIIIVAANGNDIFGGKEFPASYKETISV
                     GVLNKEGSKSVFNSNDDADVFISVDNKLPNSGENTSMATAYVSNKLTKLCNRNLRNMDK
                     DEILKLINELN"
ORIGIN
        1 tacccatttg aaatttcatc acatggattg ttatcgatta gaagattctg atgaagactt
       61 aggatttgat gagttttttg aggatgaagc ggtgactgta gtggaatgga gtcaatttat
      121 tcaagactat ttgccaccac attatttgaa aatcaacatt caaacgataa acgaaacaga
      181 acgagagctg agttttgaag cacatggctc acattttgaa gagataaagg aggccatcga
      241 acatgtacag tttactgatt gatagtgcca atcagccatt atcagtagcg attatgcaag
      301 agggtcacgt attgataacg catacgacaa cgataaaacg taatcactcg gtgcagctca
      361 tgccactcat tgaatggtta ttacaacaag cacaattgaa gccgaaagat ttagatgaaa
      421 ttattgtcac agaaggtcca ggttcgtata caggattacg tatcggggtg acgacagcga
      481 aaacacttgc ttacacattg aatattcgat tgtatggtgt gtcatcgtta aaagcgattg
      541 cagcacaaat tcaatattct gatgcgtata ttattccagt catcaatgcg agacgacaac
      601 acgtttatgc cggtgtttat caatggcaac aaggtgaact tgttaatgtg atggtggatc
      661 aatatacacc actcgatagg ttaattgagc aatggacaac aaacgacaac gttatctttg
      721 taggtgaaga tgtggcacaa tttgaaacgg aattagcacc ctttaaacga ttaagtgcgc
      781 cccctcgagc ggatcaaatg tacccacata aaggagcgcc acgcgatatt cataccttta
      841 caccgcaata tttaaaacta tcggaggcgg aacaaaattg gctgaatcaa caaaaataga
      901 agatcagctt caaattagac gtatgtccca tgaagatgtg cctgaagtgt ttgacctaga
      961 gcaggcgagt tttcaacata gttcatggac gattgatgcc ttttattatg aactggaaca
     1021 aaataacttt gcacattatt tcgtgctcga atatgaccaa cgcattatcg gttacttagg
     1081 attatgggtc gtggtcgatc aagcacaagt gacaactatt gcgatagatg cagcctatca
     1141 aggtcatgga ctaggacaaa tgctattaaa atatgggatg aactatgtgg ggtctatagc
     1201 gacagtgatg agtttagaag tacgtgtcga taatgtcgtt gcacaacatg tgtatcgaaa
     1261 gctcggtttc caatttggag gcaaacgaaa aaattattat ggtgatggag aggatgcatt
     1321 agtcatgtgg gtgaatttat atgaatgaac aaacaaagat tcttgcactt gaaacgagtt
     1381 gtgacgaaac aagtgtgagt gtcattgaaa atggtcaaac gattttaagt aacagcgtat
     1441 taagccaaat tgagagtcat caacgttttg gaggagtcgt tccagaagtg gcgagtcgtc
     1501 atcacgttga aaacattacg gtcatgattg aagaagcgtt acaacaggcc catacatcaa
     1561 ttgaagatgt ggatgctgtc gcggttacac aaggacctgg actgattggg gcgttactcg
     1621 ttggtgtgaa tgctgcgaag gcactggctt ttgcgaatga taagccgctc attccagtcc
     1681 atcatattgc cggtcatgtt tatgccaatc aacttcaaag tggcttgaaa ttcccattga
     1741 ttgccttaat tgtttcaggt ggtcatacag agcttgtcta catggaaaat catttgcaat
     1801 ttgaagtgat aggagaaaca cgtgacgatg cagttggtga agcgtatgat aaagttgcac
     1861 gtaaaattgg cttaccatat ccaggtggcc ctgccattga ccgacttgcc actcaagggg
     1921 aagacacgta cgactttcca cgagtgtggt tagaaccgga tagctatgac tttagtttta
     1981 gtggtttaaa gagtgcagtc attaataaat tacatcaatt agaacaaaaa ggtgatccga
     2041 ttattccaga aaatgtcgca acaagcttcc aaaatagtgt tgttgaagtg ctcgtaggaa
     2101 aagcaatgcg tgcatgtgaa gcgtatggtg tcaaacaact catcgttgct ggtggtgttg
     2161 caagtaatcg aggtttacgt catgcgttag aagtcgcaac tgctgagaaa gggatagagc
     2221 ttgcaattcc agagcccaaa ttatgtactg ataatgcggc gatgattggt gcagcagcgc
     2281 atgaaattta tttaaaagga attcgtggag atatggcgtt gaacggtcaa agtagtatgg
     2341 atatcgagat gtaccgagat taagttgtta agtaggtctt gaacatttca attatgcaga
     2401 gattcatgga gattgctgaa ccattctgcg ctttctaaca aaatttaatc aaaagggatt
     2461 gggatatttg gttttcccag tcccttttcc tacgatttgt caagggttca ataattaaaa
     2521 ttgacattac tgaactagac cgtccaattt ttactttttt gaattaggtg ttatgattat
     2581 atggttgcgt tagtgtggtg ctttctgata atcatataat ttattattga ctatcaagta
     2641 gtgaatggtc tttaataagc gattgatact cgctattacg gcagtcttgt gggttttccc
     2701 atgaggctgc tctcttaatt tataataata atccacaata tggctttgat aatgatttct
     2761 tcccctaata atgttcataa tgattaagta caataaacgt cttgcttttg atggaattat
     2821 attcattatt gatgaaaaca tcgacgaaaa atgagcataa attagataaa aagttgatgc
     2881 tattgttttc tagatttcat aaacttgccc ttagtttcgc tgtatttcat ataatattac
     2941 ccagaaggct gagatgcctg atggaatgca tactgctgac agttgccgct tctctttaat
     3001 agtggttact gtttatcgca gtagctgtat gacttctcaa tgtttacact tttaagaagt
     3061 cgagtcagcc atgcgggggc agtacggcga aatctttgtg acacatgata tttctgtaag
     3121 gctcccccca atccattaac gcgtaaacaa gtgtaacagt ttaatcaagt cgaattgagt
     3181 tgaagggcta gcccctagga aacgcgaagc catgagggca atcaaaagca taattcgtgg
     3241 gagagggcaa ttttaacgag aatattgcat caataacatc aaaaatttta atgccctatc
     3301 tccttttgcg ttatattgat catttttagt atacttttaa gtttcaagtt gcttcacata
     3361 tgcttgagca tccgtgtaaa tacgatttgg aaactgcatg atgcgaatta attccagcgc
     3421 atttctcgta tttgccgggc cttctttaat atgataatca aacactattt ctccgtcggt
     3481 cacatgctca ttaaagtgat aattagcata ttgatgagct aaaacttctg ttaattcaat
     3541 atcatgtgtc gctgcgataa tttttaaatg agacagtttg tttaaataat ccaggacggc
     3601 gtgtgaagcg gcgacacgtt cagtagtatt tgtccctttg aaaatttcat caataaaata
     3661 ataatgttga acggctgcat cttgaagaaa caatcgtttg agtgatttca attctgccat
     3721 aaagtaactg tcgccacttg tgacatcatc ggcatttgcc attgtcgtct ttaccatacc
     3781 aggagtgtag tgaaacttgt cagcggtcac tgtacgtatc gcttgagcca tgatgagatt
     3841 caatgcaaca gctttcataa atgttgactt accagaagca ttagaccctg ttatcaaaac
     3901 attttgattg aaatcgaagt catttggtac cgcttcatca atcagtggat gggtcaaacc
     3961 ttcaaatgtg acatgatctg cttcaacagg ctcagacgta tcgtaatgac aacgatattg
     4021 atacactgct aataaactat ccaattctcc gatatagcgg taacattcta aaacggtatc
     4081 ataatgtttg ataaaacgac gaacgagtgt ggcgtataaa tgaatatcga ctaaaaacat
     4141 atacttaaaa accattacga aatatcctgg aatcgtttcg acgttaatta ataaaaaacg
     4201 taaccgcgaa atcgaactta atggttttaa tgaatgattg aactcaggtg ttattgtcat
     4261 ttttgaaagt atttcagttt ctcttacgac ccgtcccata atgaaaagtt gctttaaatc
     4321 tttttctaca tagtaattgt aacgaaaact aataataata ttgagaaaga aagcaaaaca
     4381 aatccataaa agaccaatac ctaaattgaa aaaactaatc ataaggccta caaacggcat
     4441 agcaagtaaa aatgcataaa tccactgata ttgttgtttt aatatgtctt tgtcataatt
     4501 gggataaatc gactttccga ggtcaacgag tcttttcacg atttctcgat gctgattcgg
     4561 gtatggacgc agctgctcta aaaattcata atgaacgagt gacgtttgta atcgtaatgc
     4621 actatataaa tgattttcac ctatggacgt gtatgtcgca ttgagtttgt caaataggag
     4681 atccattgat aaatctgacc atgttttgtc gtcgattatc gtatttctag cagtatgccg
     4741 agaattgaaa tatgcatcat aaacagcgtg aggattttcg gttgtatcaa accgtgtgaa
     4801 atgttccaaa tggtaagtta acatacgttg atggcggata cgacgcacag tttctgttat
     4861 caatgtcata ccaacgagtg ccactacaag cagtaaaatg aaaaaagtat tcgaactcat
     4921 atgtataaat cctttcaata ttttaaagat tatataaatt tttacacaat atgatgagga
     4981 aatcaataaa ttgtgaaagc gtttgaatca ttgggacatg atttcaaatt catgtagtag
     5041 gaaatctgtc aagagggaac gtgcgtactt atgcacaatt tgtgaataac ttgtgtgtaa
     5101 gtttgatgcg tttttgtgga taaagtgggg ataagtgtgc ataaagtaag aagaaagcct
     5161 ctcctaaatt gtggataact agaataactt tgtggatagt tgatattatc cgattcttaa
     5221 tgtggatgaa ttgtctgtat ttcgcgtatg aaaaatgagc ggagtagaaa attccaccac
     5281 gctcaatcca tctcatcttc aaattgactt aatgtgagtt gtaattcttc ccaatttgtc
     5341 atcacttgtt ctaaagattg ttcgatactt gttcgttcgt tagctaaagc ttgtgttttt
     5401 tcataatcat tcattgttgt atcatcggtc attgcaacat caattgctgc gatacgtgct
     5461 tctaattccg tgattttttg ttcatccgct tcgatttggc gttcaatttt acgtttttca
     5521 cgacgtaacg ctttttggtc ttgatacgta ttttgtgaac gggccgagtc gtcactggta
     5581 ttgttgtctt cacgttgttc atcgtatgca gcaagggcgt tttgttgctc tagcttttct
     5641 aagtaatatt ggtaatcacc taaatacaga tggccgcctg tcttatttaa atcaaaaata
     5701 cgattggcaa gttcattaat aaaataacga tcgtgtgata cgaaaattaa agtcccttca
     5761 aagtttttta atgcttgttc taacatttcc tttgagtcga tgtcaagatg gtttgtcggt
     5821 tcgtccaaaa tgagtacatt attacgctct aacattaata atgccagttg gagtcttgct
     5881 ttttcgccac cagaaaggtc attaatcact ttgagcactt catcttgtgt aaataaaaag
     5941 cgtcctaaca ccgcacgaac atctttttca ggcatatgag ggtattggtc ccagacaaaa
     6001 tctaaaatgg ttttattaga acggaactct gcttgtttct ggtcgtaata accaattttt
     6061 aaattagcac cttcaataat ttgaccggag agagggggaa gtcgtttcgc taaagtttta
     6121 attaatgtcg atttcccaat accattcggt ccgataatgc caatgtgatc gcctttatta
     6181 atttcaaaac gaatcggtgc tgtaatcggt gtacgataac ctatctctaa atcttggata
     6241 tgcataacgt cattgcctgt attgcgatcg aaatcgaatt gaatgttcgc acttctcgca
     6301 tcgagcatgg gcttttcgat acgtgtcatt ttttctaaca ttttacgacg acttttcgcc
     6361 ataccgcttg tagatgcacg ggtaatattt ttttcgacaa acgtttctag tcttttgatt
     6421 tcgctttgtt gacgttcata ctccgcgagt cgcttttgaa agtattgatc acgtaactga
     6481 ataaattttg cataattgcc gacataatgt ttcacttcgc ctagagagac gtcatagatt
     6541 tgcgtcacaa ttttatcgag gaagaagcgg tcatgtgaaa taatgacgat agcaccttta
     6601 aaatatttca aataatcttc taaccattct gttgttgcca tgtctaaatg gtttgtcggt
     6661 tcatcgagta atagcaagtc tggctcactc aataacattt gcgcgagtga gagccgtgtt
     6721 ttttgacctc cactaaaatc attaataggt cggtcgtaat cagcctcact aaaatcaagg
     6781 ccatttaaca cagttttgat tttactatca taatgatagc ctccgagttg ttcaaattca
     6841 ttagataatt gttcatattt tgcgatatgc gtttgatatt ccgtcgtttc ataagcttcc
     6901 gcatgtgcag caagccagtc ggtttcttct tgcatacgtt tgccaatcgc tttcacttgt
     6961 tcaaaaggtt ttgccatttc ttcaaagact gtattttcag tatttaaagt catttgttgt
     7021 gttaaatagc cgagttttag acctttgatt tttgagatgt ggcctgagtc atatgattct
     7081 acacctgcga taattttcat caatgtggat tttcccgcac cgtttcgacc tacgatacca
     7141 atgcgctcac ctgttttcac ttcaaaatta acgccttcaa aaatttcttc gccatcaaac
     7201 gatttcgtaa tctgacttaa ctgcattaaa atcatagggc atactccttt cattcttatt
     7261 tattgtacaa caaaccctat atgtatcaaa tacttaatgt ttccttatca tataaattaa
     7321 gttataatta aacacacaca ctgtgaaagc tatcacatat attagaaatc atatcggagg
     7381 acttcaaaat gggaaaatca atgaacaaaa ttcctagagc gactttaaaa cgtctccctt
     7441 tgtattatag atttgtgaat actttaaaag cgaaaggcga agatcgtgtt aattcaaaag
     7501 ccattagtga aggcttaaat atagattcag ccacaatacg tcgagatttt tcttattttg
     7561 gtgaattagg taaaaaaggt tacggttata atattgatag tttattagaa ttttttaaat
     7621 cagaattaag tgattcagat attatcaaaa ttggtattgt cggtgtcggt cacttaggta
     7681 cggcgttaat ttcttacaac ttttcaatac atgatgatat gaccattaca gaagcttttg
     7741 acattagaga agacattatc ggtactacag tcggggatat tacgattaag ccgatggacg
     7801 acattaaaga aactattgct tcaggagaat tagaagttgt tattattacg acacctgaat
     7861 cagcagcaca ggcagtgact gatcaattag tcgaagcagg tatcaaaggt atcttgaatt
     7921 ttacgcctaa acgtgttcac gcgccacaat cagtacaagt acatcaaatt gacttaggga
     7981 ttgaactcca atcgttactc ttctttatga aaaattatgg tacatctgaa gcgtaaaata
     8041 aatcaagtat aaatatttta gtgatttgta tgaatcaaag tgtgagactt catcatttgt
     8101 ttttacaagc aaatgagcgg ttatagcaaa ggctagggga gagatttcct agcctttttt
     8161 gaatttcatg aggaagtcaa ataaaacaac taacgaaaag gttataaatg atagaagtca
     8221 gtcattgctt gattaaagtg tacggtctta atgtagagaa aaattgttaa catcactatg
     8281 aagatgaatg aaaaatagaa aagcatatat tgttgtgata tcagtccaat agttatagaa
     8341 ccgaaagtca ttcctaaata tcggataaag ttaaatatac ctaatacttt gccttttata
     8401 ttttcatacc gttgagatat taaagttgat agtaaggccg gaacaatgcc gactaagaag
     8461 ccaagtgcaa atataatgag cgacaaaaca attaaattta aataatgcat taatccaaag
     8521 gacagtgtaa aaatagcaaa agtaatcaca gtatttctta atatagtcat gctatctttc
     8581 acttttgaaa tctttttata aactatactt ccaattataa cgctagtggt gataggtaaa
     8641 aataaaatac ctatcataat tggtgcaata ctgtatgagt tgcttaagag tataggcaaa
     8701 tatactaata tagaaaagta ggtgaaaaaa actaaaaaac ctaaaaatac taaagtgata
     8761 aaaactttat cggttaaata gtttttccca cttaaatcca catttgattg agcaactgcc
     8821 tttatagcat ctggtatatc aattaagtaa agaactataa ataaaagaat agagactaca
     8881 agtaaaaaaa cgaaaatccc aaaataattc catttagcgc ctagtacact tcctaatatt
     8941 ggcgctaagg ccggggcaca tgacaaaaat atttggtaat ttgccattac ggatgctctc
     9001 tcattatttg tagttaactg agctaacaaa gttaaagtca caagagggat aataccgcaa
     9061 ccaatagctt gcagtaatct agataccaca aatataataa aattgttagt gatagaacag
     9121 ataaaacttg aaataataac aattcccagt cctactaaaa gtgttctttt tgagttttta
     9181 gagtctatat tttttcctaa taagatttgc ataatcgcaa ctatgaaaat gaagccacca
     9241 actgtgaaat tgatccaaaa taatgatact tgaaaactat catgaagttt tggaatgata
     9301 ggtgtgtaaa tattttgaat taaagaagca aaaaaagcta aaaaacataa aatataaaga
     9361 ttaaagtcat gttttgtttg aatcatcata atcaacttct tcctctttta aagcgctaat
     9421 actacgtgac aaaaattcaa caatgacgtc taactctttt tcattaaaga cttttaaaac
     9481 ctcttcatac tttttaactg cttgattgtg taattcgtca tgaatagaag aaagtttttt
     9541 tcctttttta gttaatttat aatgaacctc ccttttgttt tgtgcatttt gtaattcgag
     9601 aactaaatct ttggataaca gctttttaat agattttgtt actgctggat tagagatatt
     9661 taatttatct gcaagaaatt tattattaac tttatcgtta tttgctatta attctatgat
     9721 atgaaactgc gttagagata gattaagccc ttcatctcct tttatgtttt tccttctttt
     9781 attagcattt tctctctcta taatgaattg ttgtaatgtt attatgactt tttgttgttt
     9841 attcataatc atcgcctcct aattgttaac tggttaataa tattattata attaatcttt
     9901 ctgttgtcaa gtagtattgc taaaaatata tgaatctgat atcttattat taaccggaaa
     9961 attgtttatg ggttaactaa agcggaggga ggcgcttata atgttgcaac aattcaaagt
    10021 agatttttta acagaaaact gcaaaaaaat ttatcaaaga aaaaagcatg ttatattagg
    10081 tatcagtcct tttacaagta agtacaatga aacctatatc agaaaactaa ttcaatgggc
    10141 taacacaaat tttaaagact tttctattct gttagctggg gaggaatcta aaaatctatt
    10201 agaatgtctt ggatattcta ctactaaagc taatagaaag gttcgtaaag aagtgaatag
    10261 acaaatcaga ttttgtgaaa atgaattatt aaactgtaat agaaccataa atgacagaat
    10321 attcagattt tcggatttta aacaaaatac ttactatgta aatatgtacc agaaaataga
    10381 gggattgttt aatacagatg attcatttaa aaaatgttgc ttaaatatgt cgttgcaagc
    10441 cctacaaagt aaaaaaaata atctcaattc aacaatagaa tttacaaatg atatgttaga
    10501 atattcggct caatatgtgt tagccgagtt gccattcttt ttaaatgcta atccgattat
    10561 taatacttat gaaacgctga tggcttacca tgcggaatgg gaattaggta caaatattat
    10621 aaataatatg ttcgatttga aaatggatag tcatcaaggt tatattatat taactgatag
    10681 aggggataat tatgttaaaa caatctaaaa gtatttttga tgaagcttat gaaatcaatc
    10741 ctataccata ttttaattat ttcagagagt acgctcctat tcattatgaa gaatctgtaa
    10801 atgcatattt tgtatctaat tatgaggatg taaaatttat ccttaagagc gatggaattt
    10861 ttacaactaa aactttagct gaaagagctg aaccagttat gaaggataga gtcttagcac
    10921 aaatgactgg acatgaacat agatctaaaa agaaggaaat tttgaaaggt atgtcaggaa
    10981 aatatcttga tagattactt ccaaccatag aaaaaagaac aaataattta atcgataagt
    11041 atattaatga aaagaggata gatttagtta atgattttgg gaaaatattt gctgtacaaa
    11101 gttctatgga tttactagga attgatatta gagattctga caaaattaga gaatggcata
    11161 atggcatagc aaaattcatc acatcattta acatgagtag cgaagatgtt aagtattcac
    11221 tgagttgtag cgataagttg gaaaaatatt taatgccatt aattaaagaa agaaaaggca
    11281 taaaaaaaac tcgacttaat ttctgtttta aatgattata aagatgaaaa aagtcaaatt
    11341 actgattcag aaattttagc tttaatttta aatattttat tagctgctac agaacctgtc
    11401 gataaaacat tagcatactt attttataat ttattgaata atcctaatca atatcaagac
    11461 atattagata accctagttt actaaaaaat gcaataatag aaacacttcg tttcaattca
    11521 ccagtacagt taatacctag acaattatcg atgccttata cttttcgtga taaaaagtta
    11581 aatgttgatg atgtggtaat atgcatgatt ggtgcggcta atagagaccc aaaagcttat
    11641 actgctccag atgaatttaa tatatataga aaatcaaaaa ataataaacc tttcacttca
    11701 tactcacaaa atttatcatt tggctttgga gtacatactt gtataggagc aacgtacgcc
    11761 cttattcaat tggaattggt agttagaaca ttattgaaga gattgaaaaa tattaaatta
    11821 gaaactaatg tattacatga aagaggcata tatacgagag gaccaaagtc attgataatt
    11881 agttttgatt aatttgttaa aatatcgatt gtcaaggtgc tatcaataac tatttactac
    11941 attaaagctt ttcgaaaaga taaatacagt aaaaataatt aagtttatat aagtatttcc
    12001 tcattgatgc attcaaggac aatataaaaa attgtaaatt tagaagttga acatgtttgt
    12061 attgctcaat catatacaat aatgaattag aacctcaatg aacattgaaa gtttggttag
    12121 aaatagtact tttaaattaa ataagatatt ttcttaaggt aaaacaataa aaatgaaaaa
    12181 gtccttccaa ttattattca caaacaatga tttggaagga catgcttatg cctacattag
    12241 aatgctatac atactgtcag tgattactta aaaatacagt tacagttgcg gtgtcaaaaa
    12301 ttaattttca actaataata gtcaatacca tttcttttta aagttttatg ttgagttaag
    12361 aaatgagttt cggttattgt cagaaaacta caaccagtaa atgggaagaa gaaaatcaca
    12421 aaaatcagtg ttcaaacggt agcgacgatg ttctgtttga caggtttatc tccaaatttt
    12481 gatgcgattg taggaaaata tccaatctag aagtggacct aaaccaatta agagcgcgac
    12541 catatttatc gcactcaact atatctatta gagaatctat tttttattaa tttaatttac
    12601 caaattttct gacaaattcg atatattaat tttattttga tatattatct tttgtaatga
    12661 tacacccatt tctcaatgat tttttgtaaa ggggcttcaa gtttatgcgt agataatgaa
    12721 ttgaaagtat taaatgacaa aagaaacgaa gagaattttc tcatggatag acaccagtat
    12781 ccactgtgta aaatcaggtt ttttttcatc tcatatcgta ttttatacag aaatcgtgag
    12841 gggttttatg ataaaatagc tattgagact gtgaggtgat gaacaatgaa tatacaggat
    12901 atcgccaatt tagcgggcgt ttctaaaagt acagtttcaa ggtatttaaa tcaaggttcg
    12961 attagtttaa aaacaaagcg aaaaattcaa cacgtcattg atacatacgg ttatgaaccg
    13021 aaccaatttg ctcaaagttt aagagcacaa aagagtatga tgattggtat tattttcccg
    13081 agaatgtatt ctcatgccgt gtcacaaacc gttaaaggga ttaaagcgaa atgtgacgca
    13141 tttggctatc aaatgttgtt aaatttaact gagcgtcatg tggaacagga actagatgca
    13201 ctgaaatctt ttaaaagaag taaagtggat ggcattttat ttatggcgac tactgtgaca
    13261 gatgcacata tggctgtcat tcaagaaatt gataaaccag tcatcatcat tggccaagca
    13321 catgcatcgt taagttcggt ttaccacaat gattatcaag ctggtcaact aatgggacga
    13381 gaaattatgg cacaagggaa gcaacatgtc atttatgcga gtattcaaga agatgacgtc
    13441 gcggtcggtg agcaacgttt tcgaggtttg attgaagtgt taaccgcaaa tcaggtgaca
    13501 tatgagacat tgatgacatc gtttgattat gaaaccgcac tgcaatcaat taaaggtcag
    13561 cttacccaac aaccatctgt ggcgtacgtc ggtgcgacag atacgattgc tttggcgctc
    13621 tatcaagcgt tgatgcacga ccatatgacc gaaccgccgt ggattgctgg ttttggcgga
    13681 gatcctatga cacaaattgt tcatccaacg attttcactc taccttatca atatgaagcg
    13741 gcaggacgta tcgcatttga acaattacag cttcaaatgg aacagccgga tcttattcaa
    13801 agttgtcaac ttgacgtgaa ttccaaatta tgagggttta tctcaaaaga ggtggaaccg
    13861 ttaccaatgt gttaaaagga ggtatatcat ggagcaatgg agtagagaaa agcgttatcg
    13921 taagtatgaa gaagcaacac atgaggaatt ggagttatta acggccaaag tgaaccgctc
    13981 tccatttcga caaacctacc atattcagcc cccaacagga ttattaaatg atccaaacgg
    14041 tttgatcttt tttaatggtc aatattatat cgcacatcaa tggtttccac taggtgccgt
    14101 acatggttta aaatattggc ggttactcac aagcaacaat ctcgtacagt ttgaagatcg
    14161 tggtgtcgta ttacgcccgg atcaaacgtt tgatagtcac ggcgtctaca gtgggagtgc
    14221 attttcgttt catcaaaaat tgtattatat gtacacaggc aatcatcgtg acaatgagtg
    14281 gaaccgtcac agtagtcaaa tcgtagcaga agtgcaagca aatgggtcag tccgtaaact
    14341 attacctcca gccattccgg cacctcctca agggtataca caacactttc gcgatcctaa
    14401 agtgtttgag aaagatggga aactgtatgc attgctagga gcacaacgtg aaaatgaaac
    14461 agggtgtgcc gtattatacg aagctgaacg ccctgaagga ccgtggcagt ttaaaggtga
    14521 aattcaaacc caattagaag attttggtta tatgtgggag tgtccagatt attttcaaat
    14581 tcatggaaaa gatattttgc tattctgtcc acaaggcata gaatctgaag gcgatgcgta
    14641 tcaaaacatt taccaaagcg gttacataat gggaacgtta aattttgata cattagaatt
    14701 tgatcatggt ccgtttatcg aacttgacca cgggtttgat ttttatgccc ctcaaacgat
    14761 gactgatgaa gcggggcgac gtgtgttaat tggttggatg ggtctacctg acaccgaata
    14821 tccgacagat gatgacggtt gggcacactg tttaactttg ccaagaacat taacgattga
    14881 agacggcaaa ttaaaacaaa aaccgcatat gcatttaaga aagttacgta aaaatgaaga
    14941 agttgcgctc ggttatgcga acaaatttat taaacaactc catccttatg aaggagtgca
    15001 atatgagctg gtcgttgata ttttagaaaa tgaggcttct gcgtttgaat tacaactccg
    15061 tgcatcacgc aatgaatcca caacgattcg gtatgatgca acgacacgtc aggtttcact
    15121 ggagcgcttt gatagtgggg cattaccgta tccagttgaa ggaacgatga gggtgacgca
    15181 attacatacg gatttgaaac aattacgtat tttcgtggat acatcaagca ttgaaatctt
    15241 ttgtaatgaa ggagaacgag tgttgacgtc acgcattttc cctaaagcga catcaaataa
    15301 gtttaaagtc gtcacagatt ccggtcaaat ttatttgaaa atgactaaat acgatattgt
    15361 ggaaggagga taatgaatga aacgttttta tgcaataggt gaagcgctca tcgattttat
    15421 tcctacacaa agagagacgt cattgaaaga tgtgacaggg tttgaaccgc aagtcggtgg
    15481 tgcaccgtgt aatgtggctg ctgctgttca aaaattaggt ggcaacagtc atttgattac
    15541 acaagtgggt gaagacgctt ttggtgacaa aatcatcgag acgttacaag cggttgaagt
    15601 agacatctca catattttaa cgacaaaaga agcgaataca gcacttgcat ttgtcagttt
    15661 atctaatgat ggagaacgag acttttcatt ttaccggaag ccgagtgcag acatgctata
    15721 tgaagctgaa aatattgaca caattgagtt gcaacaaggt gatttagtac atttttgttc
    15781 ggtagcatta gttgacagtc ctatgaaacg cgcacatgtg aaattactgg ataaggcgga
    15841 acaagtcggt gcgaccgttg tgtttgatcc gaatgtgcgc ttacctttat gggatgacca
    15901 tgatgtttat tacgagacat tgcaagcatt tttaccacgt gcacatgttg ttaaagtttc
    15961 agatgaagaa ctgtcatttg ttacacgaca tgaggatgaa gcggaagcgt taaaatcact
    16021 gtttgtcggc aacgtgcaag cggtcattta cacaaaaggc agtcgcggag catctttaat
    16081 tttcgaagat ggctcaacaa ttgaagtgcc cacaccgcca gcgcaagtgg tggattcgac
    16141 aggagcaggc gatgcattta tcggtgcaat cagtgcgaaa ttatgtcaat ccgagcaaca
    16201 accaattgag acattacgcc aacacgggca tgatatttta aaatttgcac atcaagtttc
    16261 aggtcgcgtc gtgtcccaat atggcgccat ttcaagctta ccaacattag aagaacttta
    16321 attaaaaagc caatctccca cctatccggg aaattggctt tttaatgcga tatatagctt
    16381 ttaaattttc ttcaaattac gcaccgacac gtaacaaaat tcttcatttt tgaaataagc
    16441 aatccgttct ttcgtatcga cacttgtaat atttcttctg tttagcacat aactgttgtg
    16501 gcatctgaag aatcgatcat cgagttgagc taactctttc aaattgccgt aaaattcgat
    16561 ttgacgattg tctaaatgcg cgattaaacg atgtgacttc ggtgaggact cgaaaaacat
    16621 cacgtcgtca tagttcacgt aaaccgagct ggttccacgt ttgagttcca aagtttcaac
    16681 agtatgatct tttgttaata aatcaagccg ttttaatgct gtttctaaac aatcgataat
    16741 gcgtgtcctt aattcttcag gatcatcttt aaaaataaaa tccatggcag ccactttata
    16801 gacaaaagtc aagtacgtca gctcactatg actcgtcaca aaaataatat tcccaacagg
    16861 atcgtgctta cgaatttcgc tccctaattt aatcccgtta atatcagact ctaattgaat
    16921 atctaaaaag tagcagccaa tatcagtcat gtttttagaa gtttctaaga tagcataagg
    16981 gtcattggta gcaagctcaa ttttcatcgg cttctcttca atcataatat agttttcaat
    17041 aatggacacc atacgttcgc gttgtttagg atcatcctca caaatcaaaa ttttcatgat
    17101 acacacatcc ttattcataa tcgttcataa tctctagttt ttgaataaaa taatggtttt
    17161 cgatcgtcgt atcaaggaat acattgtccg tttgatcaat aatctctttt aatgttgtta
    17221 atcctatacc tcgattgttt cctttagttg aaaacccatc ctggaacaag gtatgtaact
    17281 taggcatatc ttttggggct ttgttcataa taataatcat tacggacgca tccgtcttaa
    17341 taaatgcgat ttgaatgata gggtcctcta tcgtgttgga agcttctatc gcattatcca
    17401 taataatacc taacacacgg ctgagttgaa tcgcatccat atcaatttgc gtgatttcat
    17461 ccgccacttc aacagtgatt tcaatattat tttcttgtgc ttgtaaaatt ttagtcgtaa
    17521 ttaagccttt aatttcacgg acttttagat tctcaatacc attcagtcgc atcgtattgg
    17581 attcaaattc gctttttaaa ggactaatat gttcatggta atattgcttc aaaccttcta
    17641 aatcatcttc acgtaaatat tcggacatcg ttaataaaat attcgtatag tcatgtcgga
    17701 atttacgcat tttgttgtta attttttcaa tttgtactgt atatttataa taatcgtcta
    17761 attcttgctt tttccgttta taattgattt cacgttcaat tgttaaagtg gttgctataa
    17821 ttaatatagc gaaaacagaa aaagaaataa aataaatgat acctaaatat ttaaaatcat
    17881 atacgttgtt cacagtttta ggcaatattg aagaaaagat gatgaatccg cttgctaaaa
    17941 ataaaacaag catagctaaa taaaacttat tcatatagag ccaagatgat ttaaatttat
    18001 taaatagagt tacaaaaact aaagaaaaac aaaaacaact aaaagtaaat accatcatat
    18061 acactaacgt agacaagtaa tagtttacgg gatacgcata aagatatgta taaacaccag
    18121 tcgctataaa atcactaata agtaaaatta atatagagat tagaacacta ataatgccta
    18181 caattttaga tcgtctgtaa taaaaaatga aaaaactaag aattaaataa agcaaactat
    18241 ttttatcgaa aattaaatat aaaataatag aagggattac tatcccgagg atgagaataa
    18301 tgtaatccct ttgactatat ttatattttt ggataatact cgtaactgat gcgaaaataa
    18361 aggattgaaa taacactaca aatatgaaaa aaagtatttc caattttata cacactttct
    18421 aacttttatt tgtcctcttc taacaattcg gcagggattt ctggctcatc aaaaaatcca
    18481 gtactagtag ggtatttagc aaaagtaccg attgattgga ataaatttgt aataaggttg
    18541 aataaaactt ctaaaattct catgttaaac ttcctcctta gtataaaaga taggtaataa
    18601 tgtgaatgat tgtaataata ccccataaac gacaaagcga ttataaggcg ttggtacgaa
    18661 gaatgcaaga gtcatgagta aaatgaatac aataattgat ttgattttaa ggcctttcac
    18721 tcttcttgga gctattggtc tttttttcgt tgcagcgggt gcatatttga ttacgatcat
    18781 cgcagccaat atactcaagc ttaacaaaaa ttgaaacgaa atgtcatatt gtactattaa
    18841 ccatggcaaa acaacgaatg aagcaatgtt ttgtacatga caaagcattg aagttttcgc
    18901 gtgtgcacca tgtgaataac cccttaaggc aagaaaagta aggtgaacaa tgagtgtgta
    18961 taaaaaaatg tttaatagga gtgcaagccc gtaagtcaca acagctttaa atgagttaat
    19021 cacgacaact tgcatgccta aacgcacttt taaaaactca atatgactta aattctgtcg
    19081 ttgttggagc ttcagcgcca ttttttcaat tccattgtca ataagtaaca tacggctctc
    19141 ctccttgtct aaattataat acacaactat taaaacgctt tattttttgc ctaactgttc
    19201 atttatcatt cctaactgtt gtgattggtt gttttttaat attttaccat aaatttttaa
    19261 acagttaagc ataaaaatca acaacttacg cactggttaa cacaaggacc aaaaaacatg
    19321 ttgtaatata gtcatcatca cattggtgat ggagataaag tgattttgta ttaagtgttg
    19381 tcgagtacac ttaatcaaat ttactgatta agttaagtca gatgttctta gtcattgtat
    19441 tcttcgctca gcttacatga ctaagggagc aacaatctat tggagtcttt gattttattt
    19501 ataatttaag gaggtgctca ctatggcagc agatatcatt agcacaatcg ttgaatttgt
    19561 taaacttatc gcagaaacag tagcaaaatt tatcaaataa taagatttga taaaagtatt
    19621 tgttagaatc tttttcctta cttagactaa agtaaaatca ggtttcgata ttgaagccat
    19681 tgtagcaata tttaataatc ggtaaattca ctaaattttt tcataattaa taacatcccc
    19741 aattaaatag aataactgta aataaaacat tcccttaata tgaagaacag gcgagtccct
    19801 cccaagctcg tctgttcatt tttatttgat gctcatgata aaaaaaggcg ttacttctct
    19861 tgaataagag aggtagcgcc tcatatttta tatttctttt tgtgcgtagc gatatacaga
    19921 cggtcgcata ttttcaaaaa ctggaatagc acgacgttgt gtgtctactt tttgaagatc
    19981 taatgtgacg gtcatcactg tttcattttc atctgcttca gcgattattt ctccatttgg
    20041 atccactacc attgaatgac ctgcatacgt tgttttacca tcatgaccac tgccattgac
    20101 agcaaccaca tacatatcgt tttcaacggc acgtgcttgt aataactgac gccaatgtgt
    20161 gagtcgaact tcgggccatt gtgcgacata aaacatcact tttgcgcctt gtgctgcagg
    20221 gtaacgactc aattctggaa agcgtaagtc ataacaaatg atttgagaaa cacttgtacc
    20281 gtcagagagc gaataaggat aggggacaga cttgccacag gttaaaaagt ctggttcatc
    20341 taacatcggg acaagatgaa ttttatcgta ttcataaatt ttttcgccac gtcgattgac
    20401 ggcaaaggct gtattgtata cggcaccttc ttttcggtta gaaacagatc ccgcaacaat
    20461 gtccacttga taattttgtg ctaatttttg tataaaagca taactttgtg ctaaatcttc
    20521 atctgctaac ttatctaatt gaggcaatgc atagccgtta ttccacattt caggcaagac
    20581 tacgacatcc gtttgatcat ctaaatgttg ttcaaataac gtagtgattt tttgttcgtt
    20641 ttgacgtgaa ttagcgattg cgacattaat ttgaaataat tgtatttgca tcgtcatcat
    20701 cctcatttct gaattaatct tagtgtacta aatgatgaac ggtttaacaa aaatcttaat
    20761 tgaatacaat catatataca tgagggtggt aatcgtagtc acttttgttt atactggctt
    20821 tgttaaaaaa ctttaaacaa tcagaggtga atctgatggt agaatataaa aaagaacata
    20881 gcgtaaagcg actattaaaa ttaggaatcg gttcaacgag tattttatgt gttgtatcac
    20941 ctcttttatt aacacatgac gttgttcaag cagcagatat caataacagg atgccagctt
    21001 tgaatacatt gaagaccact tcatcatatg atcaaagggc acacatggat gaattacgaa
    21061 gcgccattac ttcagatagt gacactactc aaacaccatc attcaatgag ataactgtgt
    21121 cttcaactaa tgaaacggat gcagcgtcaa cggaaaatgt gaacccgagt gatgaggtcc
    21181 cggcaaagga tgaaagtgaa tcaacggcac cgagtacaga acaagacaca tctatagaag
    21241 aaccgggtac tgaagaagtg ccatctcatg aagacaatca tcacaacacc ccaagtcaag
    21301 aagagcaacc gtctccgcct gttcaaccag gaacaaacaa agatgaagag agtggagaaa
    21361 aaccgaataa agaaaatcat cggaagccga atcaaccgaa caaagaccaa ccttcaaaag
    21421 atgagaataa aaaacctgac aaaggaaaca aaccagcacc accgtctaaa gcgccaaatc
    21481 gcccggatca aaaggaagat ggttcaaaca acaccccacc acctgccact gataacggtg
    21541 gaaacagtaa tgacggtaca acaacgggtc ccaatggtgg aggtggcagt gaagcaagtc
    21601 caccaccgaa tgagcaaccg tcaaacggca atgcaagcga tacccatcaa aacggttcag
    21661 tttcaagcac caatcattcg aatcagtatg gtacatcggc ttatgatgaa tacgcaggtt
    21721 tattgaataa taattataaa tataatccat tgtttaaaga agaggttgcg cgtttaagtc
    21781 aatttggaag tcaagaccaa catgatattg caagtttgag tcgtaaagaa caattttctc
    21841 aaaatgcatt tttagatgac ttgcaacaaa gtacagatta ttttagatat caatatttta
    21901 acccgctttc cacagagcaa tactatcatc gtttagataa acaagtacta gcactcgtta
    21961 cgggggaatt tggttcgatg ccagatttca agaaaagtgg tgataagtca ttggttaata
    22021 agcatcagca agataaagtg aagaaaattg aacagcaagg agaaaatatt aatacacatc
    22081 atatgaaaaa tacgaaagaa gatacaggaa aatcattaag ttacaagccg atgatttata
    22141 ttggcattgt catggtcggt tttgtcggcc tgatcagtat gattttatgg aaacgactgc
    22201 atcatttttg gaaataaatc aaaaaagggt taggccactt taactaaagt cgtcttaacc
    22261 ctttgtacat tgtaaaaaat aaatatgaag tatttaaaag taattttgtg aagcagaccg
    22321 tgtatagttt atgaaaggaa aaaagacatc caatgcgaag tcaataaaag aatgaattgt
    22381 gtttgcttaa cggcttcttc aatcattttt tcaggcatca tgagttgaat gagtgcaacc
    22441 aaaccatttt gagccatatg aataccaatc gacacactca aacgttttgt ataaatataa
    22501 aatgccgaaa agatgatacc catgacaaaa taagctaaga aatgtgaaaa atccatatgg
    22561 acaacagcaa atactgcaga actgatcgtc gttgcaatcg tgaatttgac ccattgattc
    22621 gctttaattg cgtgatacag ttcaccaaac aatacttttc taaagacaaa ctcttctaat
    22681 aatggtccga caatcgctat caacacaata aatattggca tttgacgagc gattttcatg
    22741 attcttaacg tattctcgct cgcaggatta gccccaaata gttggacaga aatgagattc
    22801 acaaccattt gtgcgataaa cacaatgact agacctacta atatataggg tagtacatag
    22861 cgttttttct cttttggacc aagttcaaag ttcaatttat ttttcacgaa caactgaagt
    22921 atgatgatta aaatggcaac aatgataaaa gcagtgaact gaactgctat cgattgccgc
    22981 aacaattgtg cttggttgcc tgtttgaatc cagccaaccg cacgtgcaat ataaggtgat
    23041 atttgtgcaa ggatgtatag tactacggtg agtagtgaaa cccaaaatct cttcataatt
    23101 agcctccgtt caatctcttt tattctaacg gaaaataaag gtatggacaa tggctttaaa
    23161 ggtaaacgct tgaaattttg accaattttg attattatag aattaaatta gcactcaata
    23221 tatgaaagtg ctaaattgat gttgaacata aggaggcact catacatgct tagaccatta
    23281 ggaaatcgtg tagtcatcga aaagaaagaa cacgaacaaa caacgaaaag tggtattgtt
    23341 ttaactgatt cagctaagga aaaatcaaat gaaggtgtta tcgttgcggt aggtccggga
    23401 cgcattttag acaatggtga acgtctcaaa cctgaactca acgaaggcga tcgtgttgtg
    23461 tttcaacaat atgcaggaac tgaagtgaaa cgtgacgaca aagaatactt agtgttaact
    23521 gaagatgaag tgttagctgt gattgaagac taatcaaaca ttgaatataa aacaaatgaa
    23581 tccaacaacg gaggtaatag aatggcaaag gaattaaaat tctctgaaga tgcacgtcaa
    23641 gcaatgttac gtggtgtcga taaattagca aatgctgtta aggtgacaat tggtccaaaa
    23701 gggcgcaatg tcgtacttga taaagaattt acagcaccgc ttattacgaa cgacggtgta
    23761 acgatcgcaa aagaaattga attagaagac ccttatgaaa atatgggtgc gaaactcgtt
    23821 caagaagttg cgaataaaac gaatgaaatt gcaggggacg gtacgacaac ggcgactgta
    23881 cttgcacaag caatgattca agaaggactt aaaaacgtga caagtggtgc aaacccagtc
    23941 ggtatccgcc aaggtattga taaagctgtg gcagtcgcaa ttgaatcatt acacaatatt
    24001 tctcaaaaag ttgaaaacaa agaagaaatt gcacaagtcg gcgcgatttc tgcagcagat
    24061 gaagaagtgg gtcgttacat ttctgaagca atggaaaaag ttggtaatga cggtgttatc
    24121 tcaattgaag aatcgaacgg ttttaacaca gaactagaag ttgttgaagg gatgcaattt
    24181 gaccgtggtt accaatcacc atacatggtg acagattctg acaaaatgat tgctgaatta
    24241 gaaagaccat acattttaat tactgacaag aaaatctctt cattccaaga cattttgcct
    24301 ttattagaac aaattgtaca atccaaccgt ccaattttaa tcgtagcgga cgaagtagaa
    24361 ggcgatgcgt taacaaacct tgtcttaaac cgtatgcgtg gtacatttac agcggttgca
    24421 gttaaggcgc ctggtttcgg tgatcgtcgt aaagcaatgt tagaagactt agcgattgta
    24481 acaggtgcac aagtgattac agatgattta ggtcttgaat taaaagaagc gactttagat
    24541 atgttaggga ctgcaaacaa agttgaagtg actaaagaca atacaacagt ggttgatgga
    24601 gacggtgata ctgcgaacat cgatgcacgt gtaggtcaat taaaagcaca aattgaagaa
    24661 actgattctg actttgatcg tgaaaaactg caagaacgtt tagcaaaatt agctggcggt
    24721 gtagcagtca ttaaagtcgg tgcggcatct gaaactgaat taaaagaacg taaattacgt
    24781 attgaagatg cattaaactc gacgcgtgca gcggtagaag aaggtatcgt tgctggtgga
    24841 ggtacggcat taatgaacat tttcaaagac gtccaagcaa tcgaagcgga aggtgacgaa
    24901 gcaacaggtg tgaacattgt attaaaagca ttgcaagcac cagtacgtca aattgctgaa
    24961 aatgcaggtc ttgaaggttc agtcatcgtt gaaagaatga aaaatgctga gccaggtatc
    25021 ggttacaacg ctgctacaga tgaatgggtg aatatgttag aagcaggtat cgtggatcca
    25081 acaaaagtga cgcgttctgc attacaacac gcagcaagtg ttgcggcaat gttcttaaca
    25141 actgaagcgg tagttgcaaa cattcctgaa gataaaggga atgatatgcc acaaatgggc
    25201 ggcatgccag ggatgatgta aaacagctta taaatgttga tttaatggca ttttataatt
    25261 gtgaatgaca tattaataac ataaaagatt tcaaaaagat aaaaatgccg tttaattcag
    25321 atgaaccaaa cggacattta aattcattct tttgaggcgt tttccttaag cgagcaaaac
    25381 ttatgggaag cgcccttttg tgtgaattga taatctcagc ataaatcttt aaagtcgtat
    25441 ttttaaacaa ctgtattagg taagcggcgc ataaataggg tgtcccagcc cctttcctac
    25501 gattaaatat ttaactgtct ttaatttcac ctttcaatca agtattaata aacaagaaat
    25561 attcacatta aaatccatgc attttcaaga gaagagtatc aatatatact tcataggtaa
    25621 cagtggggga cataacaatt tttaattgtc ttaccttgat atattttcat caaattgcct
    25681 cattaataat ttttttaaat tttcacaatt gatgtcatgg actcgcattt cctaggactt
    25741 gcctcaactc aattcagcta ttgacagtgt acactggtat gaagccgaat tggattttcg
    25801 acagcatatg atccctcagg agtctcgtcc attttagcaa tttgaattta aatactttga
    25861 accaataaat atattataca ataataaaat aaaaacatta aaaataccaa aattagtgag
    25921 gataaaaatg gcgaagtgtc acgtctttct acatcgataa ataatagaga attagattta
    25981 gatactgtat taactaatga tttcaaaaca ggagacatta atttatccgg ggaaatctct
    26041 aatatagaag aatctaaaca ggtagattat acaattgatt taacatatgc tgatgaaaaa
    26101 gacatagctg ggtttttaat agataattta actggcgagg aacatgaatt tgatacaaga
    26161 ttggctgaag cttctgccgc acctatagta gttgtggcgg taatggctgc taggtatggt
    26221 atccagtgga ctattaaaaa gtacggtaaa aaggcagtga gtaatgctat aaaatcaaat
    26281 acgcataaag tggcgaaagg aataaactct agccctctaa ctagtaaagg agtggatatc
    26341 ggaaaattca cacaaaaagt gagagggaaa aacccagtct atagagatcc taaaactgga
    26401 tggtctattt caaaaaataa agggcagcct catggaggat cttattggaa attgttggat
    26461 aaaggtggta caagaaaagc tactttaact aaagatggaa aaatacttcg taaatagggt
    26521 gattgataaa aatgagtaat attattagtt gtatggaagt aagtggttta aaattctctg
    26581 aaggtgaaaa tgctgttcat ttagatttaa gtgaaggcga ataccctttt ttagatgatg
    26641 gaaaaagctt taacaaagat tattttgcaa ggattcataa caatgcaatt caaattttac
    26701 aagatttgtt tcaacaaagt aatactattg atatagttct tttatattat ttatatgggg
    26761 actcatttaa aaaaactaga ttcaaagaaa agtttagtta tttcaataat aacgaaatac
    26821 cagattttaa agaatatatt aatgatgaag gcattcaatg ttatattttt tcttataaaa
    26881 ataagaattt gaaggattta aattataaaa aattagtgcg agcaatttcc aatcaagatt
    26941 ttaagggttt attcccaaca attaaccaaa aagacaatta cttagatata tatttaatgg
    27001 atagtaaaag aggcatatta tttcacttgt atgatgatag aggactgtgg ctatattttc
    27061 taaataagca gtcatataaa atttattctc aaaaatacag caacctcttg tttgatgtaa
    27121 gtcatgaaat ggattaaagt ttatttaaaa ttaataatac taattttatt atcgatattt
    27181 atatatttga attataattg caagtatgaa aaaagtaaaa tagcagttct agatacaggt
    27241 gttgaaaaga aagctattaa aagcaaagta atatctcgta attttactct tgacaataac
    27301 tcgaatagcg tacatgctaa taaagtttca aaaattatag aatatgaagc agatatagtt
    27361 atttacgatg ctaaagtttt gaaccatcat ggtaacggaa gattggagga tactatatca
    27421 gcacttgact gggcaattaa aaataatgtc gatataataa atatgagtta tggctttact
    27481 aaaaattatc ctgaattaca tagaaaaata aaagaagctc atgaaaaagg cattattatt
    27541 gtagctgcaa acggtaacga catttttggt ggtaaagaat ttccagcttc ctataaagaa
    27601 actatatcgg ttggagtctt gaataaggaa ggttcaaagt ctgtctttaa ttctaacgat
    27661 gatgctgacg tattcatttc ggttgataat aaattgccta atagcggtga gaatacttct
    27721 atggctacag cttatgtatc taataaattg actaaactgt gcaataggaa cttgagaaac
    27781 atggacaaag atgaaatatt aaagttaatt aatgagttaa attaattaac aacgtataat
    27841 aattatgttt gcacaaaagt taaaaatacg aatcaatttt taacatttat gaggcaatta
    27901 ggttattaag tttgagatat gtgatgctag aatgacatca tactcgttat gatatagcct
    27961 catcacactt cataacaaaa taaaaaggtt atatattttt aacggttggt gagagattca
    28021 ctgaccgtta ttttaatttt tgatattaaa aaagcacaaa tatctctata attgtaagtg
    28081 accaaaccaa cgattaagga gatattgtgc ctatgtgtaa tgatatatca gaaatactag
    28141 gaattaaagt taaaaattta aaaatcactc aaaatttagg attacatgtt cataaaaacg
    28201 tacaggcatt attctatga
//
