LOCUS       NZ_CP015098            11512 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces qaidamensis strain S10 chromosome, complete genome.
ACCESSION   NZ_CP015098
VERSION     NZ_CP015098.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces qaidamensis
  ORGANISM  Streptomyces qaidamensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9083372)
  AUTHORS   Zhang,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-APR-2016) State Key Laboratory of Cryospheric
            Sciences, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 278x
            Sequencing Technology :: Illumina HiSeq 4000; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 10:55:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,226
            CDSs (total)                      :: 8,137
            Genes (coding)                    :: 7,871
            CDSs (with protein)               :: 7,871
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 266
            CDSs (without protein)            :: 266
            Pseudo Genes (ambiguous residues) :: 0 of 266
            Pseudo Genes (frameshifted)       :: 119 of 266
            Pseudo Genes (incomplete)         :: 213 of 266
            Pseudo Genes (internal stop)      :: 25 of 266
            Pseudo Genes (multiple problems)  :: 80 of 266
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:26:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6993516
            Orig. end                         :: 7005028
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11512
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="21"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11512
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11512
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6512](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6512)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(25..34)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    192..205
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            complement(277..1047)
                     /locus_tag="A4E84_RS30970"
                     /old_locus_tag="A4E84_30970"
     CDS             complement(277..1047)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034043.1"
                     /locus_tag="A4E84_RS30970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_30970"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_062929699.1"
                     /transl_table=11
                     /translation="MLWVLFLLAAWAVAGTACTRLCLAAVRAAAVDADTGRGRELTLYE
                     AAFLSGGPRRVADVTLVAMARQRRLLLAHTGWATVVDPRGRDEMERSVIGAIGPEGQSR
                     IAPVRATAATAEAVRGIAEGLVRAGLAVPDSARTTVTAAVRQVRVAAVAVLGLGVAALL
                     TPAPPDMPRHLVALWFALPLALTLSCLTVARVEIHPYSRWASPAGQRLLGGLTRTADGA
                     ADDRTYLTSVAVRGVGAIGEPDLRAAFTHRESHD"
     misc_feature    1048..1065
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.11"
                     /tool="antismash"
     misc_feature    1051..1067
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.08"
                     /tool="antismash"
     gene            1316..2782
                     /locus_tag="A4E84_RS30975"
                     /old_locus_tag="A4E84_30975"
     CDS             1316..2782
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034047.1"
                     /locus_tag="A4E84_RS30975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_30975"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_062929700.1"
                     /sec_met_domain="Aldedh (E-value: 5.1e-173, bitscore:
                     574.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELYIDGEWTQAAAGGRRDVINPYDASVVTTVDEADATDVDRAV
                     RAARRAFAEEDWANAPSRRRADLLLRVHDLLLRDREDIARTETLDTGKTLTEARIDVED
                     VANAFRYFAELAGKDGGRVVDVGPDVLSRVVYQPVGVCALIAPWNYPLLQASWKVAPAL
                     AAGNTFVLKPSETTPLTTIAMIRLIEEAGAPPGVANLVLGSGASVGAALTGHPDVDLVS
                     FTGGLNTGRAIMASAADGPRNIALELGGKNPNIVFADADFEAAVDYALDAAFLHSGQVC
                     SAGSRLLVEDSLHDRFVEAYAERARAIRLGNGLEEGTESGPLSSAEHREKVEGYIAVAR
                     EEGARLVTGGARPDDPALSRGFFLLPTIFADCDRSMRIVQEEVFGPVVTVERFRTEDEA
                     VELANDTRYGLAGGVWTSDASRAQRVAQRLRHGTVWINDFHPYVPQAEWGGFGRSGVGR
                     ELGPTGLREYQEAKHIYQNLAPAPSGWFKG"
     gene            2820..4376
                     /locus_tag="A4E84_RS30980"
                     /old_locus_tag="A4E84_30980"
     CDS             2820..4376
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034049.1"
                     /locus_tag="A4E84_RS30980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_30980"
                     /product="GMC oxidoreductase"
                     /protein_id="WP_062929701.1"
                     /transl_table=11
                     /translation="MATTPAHGAESAYDYVIVGGGTAGCVLAARLSEDPDCRVCVIEGG
                     PSDVGDERILRLRNWINLLGSEFDYGYTTVEQPRGNSHILHSRARVLGGCSSHNTLISF
                     LPLPQDLDDWVSQGCAGWDPATILPYRDRLLTQIVPVAEADRNPIARDFVTAASRALGV
                     PVVDDFNAEPFADGAGFFSLAYQPEGNLRSSASVAYLHPVLDRPNLTLKLETWAHRLIP
                     DESGRLTRVAVRGADGEPATVRAERELLLCAGAIDTPRLLLLSGIGPADDLRALGIKVR
                     ADLPGVGENLLDHPESVIVWETAGPLPPNSAMDSDAGLFLRRDQGQPRPDLMFHFYQVP
                     FTVNTERLGYPVPRHGVCMTPNVPRARSTGRMWLRSNNPAEHPALDFRYFTDPEGHDER
                     TLVDGLKVAREVAATEPLRDWLVREVAPGPDVVSDADLSEYGRRAAHTVYHPAGTCRMG
                     AADDPAAVCDPDLRLRGFEGVRIVDASVFPTMPTINPMVTVLLAAERAADLIRAERAAQ
                     R"
     gene            4548..4979
                     /locus_tag="A4E84_RS30985"
                     /old_locus_tag="A4E84_30985"
     CDS             4548..4979
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4E84_RS30985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4E84_30985"
                     /product="hypothetical protein"
                     /protein_id="WP_062929702.1"
                     /transl_table=11
                     /translation="MRSWALFVSAVVPLLIAFASPASEDALTNIVSLAILGVYGSFQTV
                     VLAGTARPAQGVRRESHPGPTGLAVNIRALAYGIFAIVNICWARTPEKPWWENWIVLLC
                     GAIVLGTGLLHMFTTHHYGRGDAPAGDALPDKTGSPGQG"
     gene            complement(5001..6512)
                     /locus_tag="A4E84_RS30990"
                     /old_locus_tag="A4E84_30990"
     CDS             complement(5001..6512)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034053.1"
                     /locus_tag="A4E84_RS30990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_30990"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_062929703.1"
                     /sec_met_domain="DUF692 (E-value: 3.5e-96, bitscore: 320.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERLGTGIGWRPEIADAVERMPGIDWVEAVAENVCPGHLPDSLRR
                     LRERGVTVVPHGVSLGLGGADRPDAGRLTALAERAEALGSPLVTEHIAFVRAGGPLTAS
                     PHLEAGHLLPVPRTRDALDVLCENIRIAQDALPVPLAVENIAALIGWPGEEMTEGQFLY
                     ELADRTGVRLLIDVANLHTNHVNRGEDPSKALAELPLEAIAYVHVAGGFERDGVWHDSH
                     AHPVPRPVLDILTDLASRVRPPGVLLERDENFPAPTELEHELSTIRRALEAGAVERVKA
                     ELRAAAGAAPEGRGDELFPAAGTGRREAAGDVGGGLLVEAGTARQEGARGVTGGPGAGA
                     VRRGDETGAAEATRGAFGRPHQEDVDGARQRLALAQAALLSALVAGTPVPEGFDRVRIG
                     VQARALAAKRADVVAKVAPELPVILGDGYRTAFLGYAQTHPMTSGYRRDALTFAEHLLS
                     TGRPGDAGARRELRQWWLERSGPAPRSRRPAHRLARVTRRVLSRR"
     gene            6694..7266
                     /locus_tag="A4E84_RS30995"
                     /old_locus_tag="A4E84_30995"
     CDS             6694..7266
                     /GO_function="GO:0005267 - potassium channel activity
                     [Evidence IEA]"
                     /GO_process="GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034054.1"
                     /locus_tag="A4E84_RS30995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_30995"
                     /product="potassium channel family protein"
                     /protein_id="WP_079129182.1"
                     /transl_table=11
                     /translation="MSGGSEQPHRAAREREPESRAAAVRRLRIAAGALLAAGVTAYFLL
                     PLEGLGADRPWLGWPLFVLCLALVAALLLRHVRDIVLEKPQARSGIMISLLMCLAVLVF
                     SSGYYALAQQPGQFTGLRTRVDALYFTVVTLATVGYGDIAPRGQEARLVAVAQILYTFV
                     FLTAAATALSRRMHAVVAERERRPPPP"
     gene            complement(7281..7778)
                     /locus_tag="A4E84_RS31000"
                     /old_locus_tag="A4E84_31000"
     CDS             complement(7281..7778)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993752.1"
                     /locus_tag="A4E84_RS31000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_31000"
                     /product="hypothetical protein"
                     /protein_id="WP_063827524.1"
                     /transl_table=11
                     /translation="MGLPAEPTPGGSHDQRRAPSPRPAPPDDRTPGGSGPGGSGDPLAA
                     GGIALGGILMVVYGLFAVLQGVAAIAGDEVYTSFGQYSFEFDLTAWGWIHVIVGALVVV
                     AGLGLFTGAAWARVVSAVVVGLALIANFLWLPYQPFWSIIMIVTGLFVLWSVFNYRPAR
                     MM"
     misc_feature    complement(7770..7772)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7812..8573)
                     /locus_tag="A4E84_RS31005"
                     /old_locus_tag="A4E84_31005"
     CDS             complement(7812..8573)
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034059.1"
                     /locus_tag="A4E84_RS31005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_31005"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_062929704.1"
                     /transl_table=11
                     /translation="MSEDPTPVSDSPFRSEPSARDEAPQFVLPLVVRIEKAEPPARTDA
                     LETAARAVLTILADERSAGAGEWAGVMRDWQDARIRKVVRRARGAEWRRAEALPGITVT
                     GKSAEVRVFPPVPLDGWPKDLARLQVSGTDLNDPEPPVDADPAAPVLWLNPDLGMSAGK
                     AMAQAGHAAQLAWWELSDEERAAWHDAGFPLAARTADPARWSGLTGAGLPLVRDAGFTE
                     IAPGSCTVVADHPALRREPHGPGPAASTRSE"
     gene            8616..9488
                     /locus_tag="A4E84_RS31010"
                     /old_locus_tag="A4E84_31010"
     CDS             8616..9488
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997024.1"
                     /locus_tag="A4E84_RS31010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_31010"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_062929705.1"
                     /transl_table=11
                     /translation="MRPDLCLRNAGRRYGLRGPWVLRGVDLAVAPGRLVRVEGANGSGK
                     STLLRLVAGIDAPSEGRITARPARTAYVPERFPPALPFTAAGYLRHLGTVHGLAREAAA
                     RAAGEWLERLGAAAYAETPMARLSKGSSQKVAVAQALLAEPELLVLDEAWTGLDTEARA
                     ELERAVAERTAAGGSVVFVDHDPRRLAGLPDATYAVRDAGIVRQEPSQVPDTSGPHVLV
                     EVQGPPDGRLPEDVRRTATSAEETGPGGYRLCVPAPHSDVLLRTLLTARPPWHVVSVTP
                     RTPAPQRQR"
     gene            9485..10156
                     /locus_tag="A4E84_RS31015"
                     /old_locus_tag="A4E84_31015"
     CDS             9485..10156
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997023.1"
                     /locus_tag="A4E84_RS31015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_31015"
                     /product="hypothetical protein"
                     /protein_id="WP_062929706.1"
                     /transl_table=11
                     /translation="MTALMRYHAALLVRSQRWLPPFLLYAAFLAISIQAGQPVLDSLGY
                     TAAALLPVAAWLARICVTGEPDAARGCVAAAAGPARAHVACLLVALAGATALGTLAILA
                     VTLLSDPVASDHRTRVPLAAACGAGLLAALACALLGTAVGALTSRPLLRSPGRAVPALL
                     LAALLSLVATGSPAQAAVQGLVTGSRQGEVPLPLLPLAAAALLTAAALALAGALASRRS
                     P"
     gene            complement(10148..10327)
                     /locus_tag="A4E84_RS31020"
                     /old_locus_tag="A4E84_31020"
     CDS             complement(10148..10327)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675663.1"
                     /locus_tag="A4E84_RS31020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_31020"
                     /product="hypothetical protein"
                     /protein_id="WP_062929707.1"
                     /transl_table=11
                     /translation="MSEDDYCLIDATRPPRADGPPYAECVLCREPTEYPESYKGITLCP
                     ACEWQEAQRTACSG"
     misc_feature    complement(10471..10486)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    11099..11119
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
ORIGIN
        1 ggggcacggg ccgaaggcga caccggccgc cttcgcgcgc gcggcggcca cggcggtgcc
       61 gcgtcgctcg gccgcccccg tgcggtcctc ggtgtccggc gccgcggtga gggtgctcag
      121 cagcaacgac ccggcggccg agtagaggag ggcggctctc atcgcgtatc ccttcggtgc
      181 acggtggcga cgaaagggat gtttcgtccg gcgcgggggg aaggcaagca ccgtcggccg
      241 gtgtcgggcc cgatgcctct gtgcgccccc ggtccgtcag tcgtgcgact cgcggtgcgt
      301 gaacgcggcc cgcagatccg gttcgccgat cgcgccgacg ccccgcacgg ccaccgacgt
      361 gaggtacgtg cggtcgtcgg cggcgccgtc agcggtccgg gtcagcccgc cgagcagccg
      421 ctgtccggcc ggggaggccc agcgcgagta ggggtggatc tcgacccgcg cgacggtcag
      481 gcagctcagg gtcagggcca ggggcagcgc gaaccacagg gcgaccaggt gccgcggcat
      541 gtccggcgga gcgggcgtca gcaacgcggc cactcccagc ccgaggacgg cgacggccgc
      601 gacccgcacc tgccgtacgg ccgccgtgac cgtcgtacgg gcgctgtccg gcaccgcgag
      661 ccccgcgcgg accagcccct cggcgatccc gcgcaccgcc tccgccgtgg cggccgtggc
      721 ccgcaccggc gcgatacggg actgcccttc ggggcctatg gcccctatca ccgagcgctc
      781 catctcatcc cgcccacgcg ggtcgacgac cgtggcccag ccggtgtggg ccagcagcag
      841 acggcgctgg cgcgccatgg cgaccagggt cacgtcggcg acccgccggg ggccgccgga
      901 gaggaacgcc gcctcgtaca gcgtgagttc acgaccccgg ccggtgtccg cgtccacggc
      961 cgcggcccga acggcggcca gacacaggcg cgtacacgcg gtgccggcca cggcccaggc
     1021 cgccagcagg aaaagaaccc agagcatatg ttgtttgtat gtgacacgat cccgaaaaca
     1081 ccatgcctcg ttcacgatcc ggacgcagtg ttgtcggtat gtgacgttcc gtttctctcc
     1141 ggtggcggtc cgtagacggc cggcgccgtg cgccgggcga ctagcccagc cgggtcctct
     1201 gggccgtccg gacgtcgtcg cgacggtgtg ccccgtggcc gccacccctc cgatgggcca
     1261 tgttgctgac cgtcgagccg atcgggctcc ggacggacgc gaaggaggcc ccgcggtggg
     1321 tgagctgtac atcgacggcg agtggacaca ggcggcggcc ggcgggcgcc gggacgtgat
     1381 caacccctat gacgcctcgg tcgtcaccac cgtcgacgag gccgacgcca ccgacgtcga
     1441 ccgcgcggtg cgcgccgccc ggcgcgcctt cgccgaggag gactgggcga acgccccctc
     1501 gcgccgccgg gccgacctcc tgctgcgcgt gcacgacctg ctgctgcgcg accgggagga
     1561 catcgcgcgc accgagacgc tcgacaccgg caagacactc accgaggccc gcatcgacgt
     1621 ggaggacgtg gcgaacgcct tccgctactt cgccgaactc gcgggcaagg acggcggccg
     1681 ggtcgtcgac gtcggcccgg acgtcctcag ccgcgtcgtc taccagcccg tcggcgtgtg
     1741 cgcgctcatc gccccctgga actacccgct gttgcaggcc tcctggaagg tcgcgcccgc
     1801 gctcgccgcc ggcaacacct tcgtcctcaa gcccagcgag accaccccgc tcaccacgat
     1861 cgccatgatc cggctcatcg aggaggccgg cgccccgccc ggcgtcgcca acctggtgct
     1921 cggctccggg gcgagtgtcg gcgcggccct gaccggccac cccgacgtcg acctggtctc
     1981 cttcaccggc ggcctgaaca ccggacgggc catcatggcc agtgccgccg acgggccgcg
     2041 gaacatcgcc ctggaactgg gcggcaagaa ccccaacatc gtcttcgccg acgccgactt
     2101 cgaggccgcc gtcgactacg ccctggacgc cgccttcctg cactccgggc aggtctgctc
     2161 ggccggttca cgcctgctcg tcgaggactc cctgcacgac cggttcgtcg aggcctacgc
     2221 cgagcgcgcc cgggcgatcc ggctcggcaa cggcctggag gagggcaccg agagcggccc
     2281 gctcagctcc gccgagcacc gcgagaaggt cgagggctac atcgccgtcg cccgggagga
     2341 gggcgcccgg ctcgtcaccg gcggcgcccg gcccgacgac ccggccctca gccgcgggtt
     2401 cttcctgctg ccgacgatct tcgccgactg cgaccggtcc atgcgcatcg tccaggagga
     2461 ggtcttcggc ccggtcgtca ccgtcgagcg cttccgcacc gaggacgagg cggtggagct
     2521 ggccaacgac acccgctacg gcctcgccgg cggcgtgtgg acctccgacg cgagccgcgc
     2581 ccagcgcgtc gcccagcggc tgcggcacgg caccgtgtgg atcaacgact tccaccccta
     2641 cgtgccgcag gccgagtggg gcggcttcgg ccgctccggc gtcggacgcg agctcggccc
     2701 gacagggctg cgcgagtacc aggaggccaa gcacatctac cagaacctcg cccccgcccc
     2761 ctccggctgg ttcaagggct gacccgcacg ccacacctca ccaccaggaa aggcacggca
     2821 tggccaccac ccccgcgcac ggcgccgagt ccgcctacga ctacgtcatc gtcggcggcg
     2881 gcaccgccgg ctgcgtactc gccgcccggc tgagcgagga ccccgactgc cgcgtgtgcg
     2941 tcatcgaggg cggccccagc gacgtcggcg acgagcgcat cctgcgcctg cgcaactgga
     3001 tcaacctgct cggctcggag ttcgactacg gctacaccac cgtcgagcag ccgcgcggca
     3061 actcgcacat cctgcactca cgggcccgtg tgctcggcgg ctgctcctcg cacaacacgc
     3121 tgatcagctt cctgccgctg ccgcaggacc tcgacgactg ggtgagccag ggctgcgccg
     3181 gctgggaccc ggcgacgatc ctgccctacc gcgaccggct gctcacgcag atcgtcccgg
     3241 tggccgaggc cgaccgcaat cccatcgcca gggacttcgt caccgcggcc tcccgcgccc
     3301 tcggcgtccc cgtcgtcgac gacttcaacg ccgaaccctt cgccgacggt gccggattct
     3361 tctccctggc ctaccagccg gagggcaacc tgcgctcctc cgcgtccgtc gcctacctcc
     3421 acccggtgct ggaccggccc aacctcacgc tcaagctgga gacctgggcg caccggctga
     3481 tccccgacga gtcgggccgg ctgacccggg tcgcggtccg gggcgccgac ggcgaacccg
     3541 cgaccgtgcg cgccgagcgc gaactcctgc tgtgcgccgg ggccatcgac accccgcgcc
     3601 tgctgctgct ctccggcatc ggcccggccg acgacctgcg cgccctgggc atcaaagtac
     3661 gggccgacct gcccggcgtc ggggagaacc tgctggacca ccccgagtcc gtgatcgtct
     3721 gggagaccgc gggaccgctg ccgcccaact cggcgatgga ctccgacgcc ggtctgttcc
     3781 tgcgccgcga ccagggccag ccgcgccccg acctgatgtt ccacttctac caggtgccgt
     3841 tcaccgtcaa caccgaacgc ctgggctacc ccgtcccgcg gcacggggtg tgcatgacgc
     3901 cgaacgtgcc gcgggcccgc tccaccggcc gcatgtggct gcgcagcaac aacccggccg
     3961 agcatcccgc cctggacttc cggtacttca ccgaccccga gggccacgac gagcgcaccc
     4021 tcgtggacgg gctgaaggtg gcccgcgagg tcgccgcgac cgagccgctg cgcgactggc
     4081 tcgtccgcga ggtcgcgccc ggcccggacg tcgtctccga cgccgacctg tcggagtacg
     4141 gacgccgcgc ggcccacacc gtctaccacc cggccggcac ctgccgcatg ggcgcagctg
     4201 acgacccggc ggccgtctgc gaccccgacc tgagactgcg gggcttcgag ggcgtgcgga
     4261 tcgtcgacgc gtcggtgttc ccgacgatgc ccaccatcaa cccgatggtg accgtgctgc
     4321 tcgccgccga acgggccgcg gacctgatcc gggcggaacg ggcggcgcag aggtgaccgg
     4381 tacgcggcct cccgcaccgg cgtccggcgt ccccggcggc gagccgggct ccgagttccg
     4441 caaggacatg ggcccctgag gggtcctttc actctgcccg tccggggcgc gcggcctggc
     4501 accgcacctc gccgcgttgc cgaaaagccc ttgtccacgc ccgtgcggtg cggagctggg
     4561 ccctgttcgt ctccgcggtg gtgccgctgc tcatcgcctt cgcctcaccg gcctccgagg
     4621 acgccctcac caacatcgtc tcgctcgcga tcctcggcgt ctacggctcg ttccagacgg
     4681 tggtcctggc cggcactgcc cgcccggctc aaggggtccg acgggagagt caccctgggc
     4741 cgacgggcct cgcggtgaac atccgggcgc tggcctacgg catcttcgcc atcgtcaaca
     4801 tctgctgggc ccgcaccccg gagaagccct ggtgggagaa ctggatcgtg ctgctgtgcg
     4861 gtgcgatcgt gctgggcacc ggcctgctcc acatgttcac cacgcaccac tacggccgcg
     4921 gcgacgcccc cgcgggggac gccctgccgg acaagaccgg ctctccgggg caggggtgag
     4981 gggcccgtgc ccctcacccc tcaacgccgt gacaacaccc tgcgcgtgac gcgggcgagc
     5041 cggtgggcgg gccgccggga gcgcggcgcc ggacccgacc gttccagcca ccactgccgg
     5101 agctcccgcc gcgcccccgc gtcccccggg cgcccggtgg acagcaggtg ctcggcgaag
     5161 gtcagggcgt cacgccggta gccggaggtc atggggtgcg tctgggcgta gccgaggaac
     5221 gccgtgcggt acccgtcgcc gaggatcacc ggcagttcgg gggcgacctt cgccacgacg
     5281 tccgcccgct tcgcggcgag cgccctcgcc tgtacgccga tccgcacccg gtcgaacccc
     5341 tcgggcacgg gcgtccccgc caccagcgcc gacagcagcg ccgcctgggc cagcgcgagc
     5401 cgctgccggg caccgtcgac gtcctcttgg tggggccggc cgaaggcgcc ccgtgtcgcc
     5461 tcggccgccc cggtctcatc gccccgccgt accgccccgg ccccgggccc gccggtgacg
     5521 cctcgggcac cctcctggcg cgcggtgccg gcctccacga gcagcccgcc gccgacatcc
     5581 ccggccgctt cccgccgtcc ggtcccggca gccgggaaca gctcatcgcc gcggccctcc
     5641 ggggccgctc cggccgccgc acggagttcc gccttcacgc gttcgacagc gcccgcctcc
     5701 agcgcccggc ggatcgtgct cagctcgtgc tccagctccg tcggtgccgg gaagttctcg
     5761 tcccgttcca gcaggacgcc cggcgggcgg acgcgggagg cgaggtcggt gaggatgtcg
     5821 aggaccggcc gggggaccgg gtgggcgtgg ctgtcgtgcc agacgccgtc gcgctcgaag
     5881 ccaccggcga cgtggacgta cgcgatggcc tccaggggca gctcggcgag ggccttggag
     5941 gggtcctcgc cgcggttgac gtggttggtg tgcaggttgg ccacgtcgat gaggaggcgg
     6001 acgcccgtgc ggtcggcgag ctcgtacagg aactggccct ccgtcatctc ctcgcccggc
     6061 cagccgatca gcgcggcgat gttctcgacg gccagcggca ccggcagtgc gtcctgcgcg
     6121 atgcgtatgt tctcgcacag gacgtccagg gcgtcccggg tgcgggggac gggcagcagg
     6181 tggccggcct ccaggtgcgg ggacgccgtc agcggcccgc ccgcccgtac gaacgcgatg
     6241 tgctcggtga ccagtgggga acccagcgcc tcagcgcgct cggccagtgc ggtcagccgg
     6301 cccgcgtcgg gccggtccgc gcccccgagg ccgagcgaga cgccgtgcgg caccacggtg
     6361 acgccgcgct cgcgcagccg ccgcagcgag tcgggcaggt gtccggggca gacgttctcg
     6421 gccaccgcct cgacccagtc gatccccggc atccgctcca cggcgtccgc gatctccggc
     6481 cgccacccga tgcccgtccc cagtcgctcc atcgtcccct cctccacccg gcccgttcct
     6541 cgaacgtgag gggggtatgg cccagccgcc ggcccccgaa ccgcgcaccg ccctccttca
     6601 gagcaacatt tgaggtttgc ggtcccgccc cccgccctca ccgacggagg cgcaagactc
     6661 gcgccctggc ccgatacgcc gtagaccgga cctatgtccg gaggcagcga gcagccgcac
     6721 cgcgccgcgc gcgagcggga accggaatcc cgggcggccg ccgtccgccg gctgcggatc
     6781 gcggccggag ccctgctcgc ggcaggcgtc acggcctact tcctgttgcc gctggagggt
     6841 ctcggtgccg accgcccctg gctgggctgg ccgctgttcg tactgtgcct ggcgctcgtg
     6901 gccgcgctgc tgctgcgcca tgtgcgcgac atcgtgctgg agaagccgca agcccggtcg
     6961 ggcatcatga tctcgctgct gatgtgcctg gccgtgctgg tcttctcgtc cgggtactac
     7021 gccctcgcgc agcagccggg acagttcacc ggcctgcgca cccgggtcga cgcgctgtac
     7081 ttcacggtcg tcaccctcgc gaccgtcggc tacggcgaca tcgccccgcg cgggcaggag
     7141 gcccggctgg tggccgtcgc ccagatcctg tacacgttcg tcttcctcac ggcggcggcc
     7201 accgcgctgt cccggcggat gcacgcggtg gtcgcggagc gcgagcggcg cccgccgccg
     7261 ccctgaccga ggggcgtgcc ctacatcatg cgggccgggc ggtagttgaa caccgaccag
     7321 aggacgaaca gaccggtcac gatcatgatg atcgaccaga acggctggta cggcagccag
     7381 aggaagttcg cgatcagcgc caggccgacc acgaccgcgc tcacgacccg cgcccaggcg
     7441 gccccggtga acaggccgag cccggccacc accacgagcg cgccgacgat cacgtggatc
     7501 cacccccacg cggtcaggtc gaactcgaac gagtactggc cgaagctcgt gtacacctcg
     7561 tcgccggcga tcgccgcgac gccctggagc accgcgaaca ggccgtagac gaccatcagg
     7621 atgccgccga gggcgatccc cccggccgcc agcgggtcac cggaaccgcc cgggccggag
     7681 ccgccgggcg tccggtcatc ggggggggcg gggcgggggg agggggcgcg gcgctggtca
     7741 tggctgcctc cgggggtcgg ttcggctggt aaccccactg gagcattcgt ccgggaccgg
     7801 cgcgcctgtg gctactccga acgggtggac gccgcggggc cgggcccgtg cggctcccgg
     7861 cgcagcgccg ggtggtccgc gaccaccgtg cacgagccgg gcgcgatctc cgtgaagccc
     7921 gcgtcgcgca ccaacggcag cccggcgccg gtcagtccgg accagcgggc cggatcggcc
     7981 gtgcgggcgg cgagcgggaa gcccgcgtcg tgccaggcgg cccgctcctc gtcggacagc
     8041 tcccaccagg ccagttgggc ggcgtggccc gcctgggcca tcgccttgcc ggccgacatg
     8101 ccgaggtccg ggttcagcca cagcacgggc gcggccgggt ccgcgtccac cggcggctcc
     8161 gggtcgttca ggtcggtgcc ggacacctgg agcctggcca ggtccttggg ccagccgtcc
     8221 agcgggacgg gcgggaagac ccgcacctcg gccgacttgc cggtgaccgt gatgccgggc
     8281 agcgcctcgg cccgccgcca ctcggcgcca cgcgcccgcc gcaccacctt gcggatccgg
     8341 gcgtcctgcc agtcccgcat caccccggcc cactcgcccg caccggccga ccgctcgtcg
     8401 gccaggatcg tcagcacggc ccgcgcggcc gtctccagcg cgtccgtgcg ggccggcggc
     8461 tccgccttct cgatccgcac gacgagcggc agcacgaact gcggtgcctc gtcacgagcc
     8521 gagggctcgg accggaaggg actgtcgctc acgggcgtcg ggtcttcgct cacgaatccc
     8581 agtgtgccag ccggaagata gtgcaggatg gccgcatgcg acccgacctg tgcctgcgga
     8641 acgcgggccg ccgttacggt ctgcggggcc cctgggtact gcgcggtgtc gacctggcgg
     8701 tggctccggg ccggctcgtc cgcgtcgagg gtgccaacgg cagcggcaag tccacgctgt
     8761 tgcggctggt cgccggcatc gacgcgccga gcgagggccg gatcaccgcc cggccggcgc
     8821 gcacggcgta cgtcccggag cggttcccgc cggccctgcc cttcaccgcc gccggctacc
     8881 tcaggcacct cggcaccgtg cacggcctgg cccgggaggc ggccgcccgg gccgccgggg
     8941 agtggttgga gcgcctgggt gccgccgcgt acgccgagac gccgatggcc cggctgtcga
     9001 agggcagcag ccagaaggtc gcggtcgcac aggccctcct ggcggaaccc gagctgctgg
     9061 tgctggacga ggcgtggacc ggcctggaca ccgaggcccg cgccgagttg gagcgcgcgg
     9121 tcgccgagcg cacggcggca ggcggatccg tggtgttcgt cgaccacgac ccgcgccgcc
     9181 tcgcgggcct gcccgacgcg acgtacgccg tgcgcgacgc gggcatcgtc cggcaggagc
     9241 cctcacaggt tccggacacg tccggtccgc acgtgctcgt cgaggtgcag ggcccgccgg
     9301 acgggcggct gcccgaggac gtgcgccgga cggccacctc ggccgaggag accgggccgg
     9361 gcggctaccg cctctgcgtg cccgccccgc actccgacgt gctgctccgc accctgctga
     9421 cggcccgtcc gccctggcac gtggtgagcg tgaccccgcg gacgccggct ccacagagac
     9481 agcgatgacc gccctgatgc gctaccacgc cgctctgctg gtgcggtcgc agcgctggct
     9541 gcctccgttc ctgctgtacg cggccttcct cgcgatcagc atccaggccg ggcagccggt
     9601 gctcgactcg ctcgggtaca cggccgccgc cctgctgccc gtcgccgcct ggctggcgcg
     9661 gatctgcgtc acgggcgaac ccgacgccgc tcgcggctgt gtggcggcgg ccgccgggcc
     9721 cgcgcgggct catgtggcct gtctgctcgt ggccctggcc ggtgcgacgg cgctcggcac
     9781 gctcgcgatc ctcgccgtga cgctgctcag tgacccggtc gcctccgacc accgcacccg
     9841 ggtgccgctc gccgccgcct gcggggccgg gctgctcgcc gccctggcct gtgccctgct
     9901 cggcacggcc gtcggcgcgc tcaccagcag gcccctgctg cggtcgccgg gccgggccgt
     9961 ccccgccctg ctgctcgcgg cgctgctctc cctggtcgcc accggctcac ccgcccaggc
    10021 ggccgtacag ggcctggtga ccggatcgcg gcagggcgag gtcccgctgc cgctgctgcc
    10081 cctggccgcg gcggcactgc tcacggccgc ggcactggcc ctggccggag cgctggcctc
    10141 ccgcagatca ccctgagcag gcggtgcgct gcgcctcctg ccactcgcag gcggggcaga
    10201 gcgtgatgcc cttgtacgac tcggggtact ccgtcggctc ccggcacagc acgcactccg
    10261 cgtacggcgg tccgtccgcc cggggcggcc tggtcgcgtc gatcaggcag tagtcgtcct
    10321 cgctcatacg tccagcgtag gcccggggcg agccctcaga ggtccctctg ttccaggggc
    10381 tttgtcgccg ggccctggat caccttgcca tccgtgtcga aacgggagcc gtggcagggg
    10441 cactcccagg cgcgctcggc ggcgttgaag tcgaccaggc agcccaggtg ggtgcagcgg
    10501 gcggagacgg cgtgcagccc gccgtcgtcg tcccggtaca ccgcgacacg gtggccgtcg
    10561 gcccggacca ccgcaccctc gccgggtggc agggactcca cgggcggcga aggccgcagc
    10621 cggtcgccca cgaagtgccc cgcgaccttg gcctgcgtct tgaggaacgt cggcgcctcc
    10681 cgcagcgcgg gcttcacgcg gcgcggatcg tacagcccgc tccactcgca ctcctcgccc
    10741 gtgatctgcg cggtcagcag ccggcccgcc atgatgccac cggtcatgcc ccagccgccg
    10801 aagccggtgg ccacgtaggc gtgccgggtg cccgcgtgca gcgggccgac catcggcacg
    10861 gtgtccgtgg gctccgtgtc ctgggtggcc caacggtggg tgacctccag gtccgggaaa
    10921 tggccggtcg cccaggcggt gaggcgctcg aaacgggccc gcgggtcgct cgtgcccgga
    10981 gtgaagtgct caccggtgac gatgagcagc cgccggtcgc cctcgtgggg cgcggtgcgc
    11041 accgagcggg tgtcctcgtc gggcgtgatg aacatgccgc ccgggtcctg gtccgcgggg
    11101 atcgtcccgg cgacgaccag ctcgcggcgc gtggagagac gggcgaagag cagggcccgg
    11161 tcgaagatcg ggtagtgcgt cgcgacgacg acgtcccggg cccggaccgt cgccccggtc
    11221 gtggtcgaca gcctgcacgg ctcgccctcg tccaggccga ggacggtggt gtcctcgtag
    11281 atccgcccgc cgcgttcgac gaggtcggcg gcgagggcca gtaggtactt gcgcgggtgg
    11341 aactgggcct gcccggtgac ctcgacggcg cccgccacct cgaagggcag cccggtctcc
    11401 gtgacgaacg aggcgggcag cccggcctcg gccgcggccc gtgcctcggc gcgcagctcc
    11461 tccacgcggc tcgcgccgac ggcgtaggtg taggcgctcc tggtctccca tt
//
