LOCUS       NZ_CP015098            21086 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces qaidamensis strain S10 chromosome, complete genome.
ACCESSION   NZ_CP015098
VERSION     NZ_CP015098.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces qaidamensis
  ORGANISM  Streptomyces qaidamensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9083372)
  AUTHORS   Zhang,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-APR-2016) State Key Laboratory of Cryospheric
            Sciences, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 278x
            Sequencing Technology :: Illumina HiSeq 4000; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 10:55:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,226
            CDSs (total)                      :: 8,137
            Genes (coding)                    :: 7,871
            CDSs (with protein)               :: 7,871
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 266
            CDSs (without protein)            :: 266
            Pseudo Genes (ambiguous residues) :: 0 of 266
            Pseudo Genes (frameshifted)       :: 119 of 266
            Pseudo Genes (incomplete)         :: 213 of 266
            Pseudo Genes (internal stop)      :: 25 of 266
            Pseudo Genes (multiple problems)  :: 80 of 266
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:26:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6000463
            Orig. end                         :: 6021549
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="16"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(171..1487)
                     /gene="aroA"
                     /locus_tag="A4E84_RS26760"
                     /old_locus_tag="A4E84_26760"
     CDS             complement(171..1487)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522882.1"
                     /locus_tag="A4E84_RS26760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26760"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_062928984.1"
                     /transl_table=11
                     /translation="MAPNTPDTALWPAPHASGAVDATVHVPGSKSVTNRALVLASLASE
                     PGWLRRPLRSRDTLLMAGALRALGIEIEEGVGPDGTGEAWRVLPTGLRGPATVDVGNAG
                     TVMRFLPPVATLADGPVRFDGDPRSYERPLNGVIDALRQLGARIDDDGRGALPLTVHGS
                     GALDGGTVAIDASSSSQFVSSLLLSGPRFNQGVEVRHTGATLPSMPHIRMTVDMLRAVG
                     AQVDTPESGGEPNVWRVSPGALLGRDLVIEPDLSNAQPFLAAALVTGGKVVVPDWPSRT
                     TQPGDRLREIFTEMGGSCELTEYGLVFTGSGSVHGIDVDLGEVGELTPGIAAVAALADS
                     PSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGIFHTYDDHRM
                     ATAGAIIGLAVEGVQIENVATTAKTLPDFPDLWTGMLGA"
     misc_feature    complement(1489..1505)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.34"
                     /tool="antismash"
     gene            complement(1598..2320)
                     /locus_tag="A4E84_RS26765"
                     /old_locus_tag="A4E84_26765"
     CDS             complement(1598..2320)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992842.1"
                     /locus_tag="A4E84_RS26765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26765"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_062928985.1"
                     /transl_table=11
                     /translation="MDSTATASLASLWDEVSGTQPDPDLWVVIATLGAALAVVIPHGLW
                     RISRNAITIAHEGGHGIVALLTGRTLTGIRLHSDTSGLTVSRGKPHGIGMILTAAAGYT
                     APPLLGLGGASLLGSGRITLLLWLATALLLAMLVMIRNAYGALTMLVTGGLFVLVSWLA
                     GPQVQAAFAYAVVWFLLIGGVRPAFELQSKRARGGAGDSDADQLSRLTHVPAGLWFFLF
                     HAVSLCSLIGGGRWLLEL"
     gene            2371..3186
                     /locus_tag="A4E84_RS26770"
                     /old_locus_tag="A4E84_26770"
     CDS             2371..3186
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="A4E84_RS26770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26770"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_062928986.1"
                     /transl_table=11
                     /translation="MCGRYSASRRPEDLAGIFEVEKWEPEETLAPDYNVAPTKEVYAVL
                     DRPLKDADDPRPVRQLRTLKWGLVPSWSKTPEGGARMINARAETVHEKPSYRRAFTSRR
                     CILPADGYYEWVTGTQERELEVEGKKKRPRKQPYFVTPADGSVFAMAGLYEFWRDKTLP
                     DDHPQAWWVTCSVITTEAEQSPLAVSPADGPRALAEIHPRMPLMLTPDRWDAWLDPSRT
                     DPDGLRELLAPPPAGLMRAYPVATAVSNVRNNGPELLKELEGPEEGTLF"
     gene            3197..3844
                     /locus_tag="A4E84_RS26775"
                     /old_locus_tag="A4E84_26775"
     CDS             3197..3844
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136689.1"
                     /locus_tag="A4E84_RS26775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26775"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_062931630.1"
                     /transl_table=11
                     /translation="MTKTAGTATETVETDAGTARITWHGAKKARLVLAVSHGAGGGIEA
                     RDLVALAEVLPTHGVAVARVEQPWRVAGKKLAPAPKTLDAGWRGIWPALAKSGLPVISG
                     GRSAGARVACRTATELGAHAVLALGFPLHPPGKPEKSRAEELLGAGVPTLVVQGGNDPF
                     GKPEEFPDGAFELVEIPYGDHGFAVPKRADISQDEAVSLITDAVVEWTGSLG"
     misc_feature    complement(4031..4045)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.77"
                     /tool="antismash"
     gene            4101..4787
                     /gene="sigR"
                     /locus_tag="A4E84_RS26780"
                     /old_locus_tag="A4E84_26780"
     CDS             4101..4787
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="A4E84_RS26780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26780"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_062928987.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTEHGQAEQPEGRGGTGAETAAERSARFERDALEFL
                     DQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRK
                     KQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEFRIA
                     VYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGMVPAGAGESNE
                     AKGSGS"
     misc_feature    4123..4138
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     gene            4784..5095
                     /gene="rsrA"
                     /locus_tag="A4E84_RS26785"
                     /old_locus_tag="A4E84_26785"
     CDS             4784..5095
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326971.1"
                     /locus_tag="A4E84_RS26785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26785"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_031132298.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEILDHLYEFLDREMPDSDCVKFEHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGHDDVPGDLRDKVMGRIELIRSGQAVPEQDVTASPATSQES"
     gene            5249..6586
                     /locus_tag="A4E84_RS26790"
                     /old_locus_tag="A4E84_26790"
     CDS             5249..6586
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047597.1"
                     /locus_tag="A4E84_RS26790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26790"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_062928988.1"
                     /transl_table=11
                     /translation="MEAVPARARVYIAGVAMAALLCLLPPPGVRTPWWAVALLAALYAG
                     CERVARCRFVGISHPAGTFYPVLLAGAFLLPAPAAALVVVPGALLSQAGQRPVALRRIW
                     RAAQLVLGVWAAATVHRLLGGRDAVAAGDVPYALGPAGAAVLAFCLVLALLDGGILAAA
                     ERVPVRRAWRGLVARSLAPIAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVSWWAFAQ
                     YHRERAAHQATIRALVQAVDIKDGYTRGHSERVGQASMMIARELGMADERVEVLRFAGI
                     LHDVGKLGVPTRLLRKDGPLTPEERRVIELHPEYGHEMVRGIGFLGEARAAVLHHHERL
                     DGSGYPYGLVGRQIPESARVVAVADAFDAMTSTRSYSRARPVAVALAELERCAGSHFDP
                     VMVAALVEAVGRTGWHPTVTADDEETRPARVPPPGAPLSSRPGAHR"
     gene            6583..7830
                     /locus_tag="A4E84_RS26795"
                     /old_locus_tag="A4E84_26795"
     CDS             6583..7830
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047595.1"
                     /locus_tag="A4E84_RS26795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26795"
                     /product="HD domain-containing protein"
                     /protein_id="WP_174569464.1"
                     /transl_table=11
                     /translation="MSAYRPPPLLTLVHACAALLAAGSLAVTLHHGLEERRVALAFGVL
                     VTVGELTRRSGAQVREPAPLGAAAALSYALLGEAGGRATHHGPAQVVAVVLAASLLGSV
                     PHVARGQGPTLDHLARRVLTVGFVAVCFQPPYNRGMFDDWGGPAYALLLLALLSLTALC
                     DAVLAAALAHTRTGWPFGPVLRDELRAVCGIGSAVIATGAVMALAVAVVGLWALPVFSV
                     PLLLAQMSFRRYAAVRATYRQTIASLARATEVAGYTPCGHARRVAAVSQAVGRDLGLTE
                     PELAVLEYAALMHDIGQLSLVDPVPAGATAALPAAEQRRIALLGGAVVRQTGVDEAVAV
                     VVERQADPFAEQPLAARIVRAVNAYEEKSREGGPGGPLTALEELRLATAGTYAPEVVES
                     LARVLARSSLTLPVAG"
     gene            7948..8928
                     /locus_tag="A4E84_RS26800"
                     /old_locus_tag="A4E84_26800"
     CDS             7948..8928
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="A4E84_RS26800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26800"
                     /product="hypothetical protein"
                     /protein_id="WP_062931631.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARTAGLRAVALLDRDTGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLRVPGAANDSGEPLGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTAAGHTYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGLAAPAALVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9055..9705
                     /gene="def"
                     /locus_tag="A4E84_RS26805"
                     /old_locus_tag="A4E84_26805"
     CDS             9055..9705
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="A4E84_RS26805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26805"
                     /product="peptide deformylase"
                     /protein_id="WP_062928990.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVIDTEGCEEREAAWRERGTSRPIT
                     VVGNPVLHKECKDVTDFGDEFQQLVADMFASQRTAEGVGLAANQIGVDAKVFVYDCPDD
                     EGVRHTGVVCNPELVELPAEKRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEKGNPI
                     RVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYPVVAND"
     gene            10001..11086
                     /gene="cyc1"
                     /locus_tag="A4E84_RS26810"
                     /old_locus_tag="A4E84_26810"
     CDS             10001..11086
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="A4E84_RS26810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26810"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_107308381.1"
                     /sec_met_domain="T1TS (E-value: 2.6e-64, bitscore: 217.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHALSHGTTTAPATIAVPPSLSLPVIEAAFPRQLHPYWPKCQEKT
                     RAWLLEKRLMPADKVEEYADGLCYTDLMAGYYLGASDEVIQAIADYSAWFFVWDDRHDR
                     DIVHGRPVAWRLLRDRLHSALDSPGEHLHHEDPLVAGFADSVLRLYAFLPQTWNLRFAR
                     HFHAVIDAYDQEFHNRTEGIVPTVEEYLRLRRLTFAHWIWTDLLEPTAGCELPDAVRKH
                     PAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHEGMTLERAVAEVRRRVE
                     ECITDFIQVEREALRFAEDLADGSVRGKELSAAVRACLSNMRNWFSSVYWFHHESGRYM
                     VDSWDDRSTPPYVNNEAAGEK"
     gene            11083..12453
                     /locus_tag="A4E84_RS26815"
                     /old_locus_tag="A4E84_26815"
     CDS             11083..12453
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326965.1"
                     /locus_tag="A4E84_RS26815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26815"
                     /product="cytochrome P450"
                     /protein_id="WP_062928992.1"
                     /sec_met_domain="p450 (E-value: 1.1e-69, bitscore: 234.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVKPEIPPAVELREPPRAGGGVPVLGHGWRLARDPLAFMAR
                     LRDHGDVVRLKLGPKTVYAVTTPALTGALALSNDFIIAGPLWESLEGLLGKEGVATANG
                     PRHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWKPGETIDCTSESFRVAVRIAAR
                     CLLRGDYMDERAERLCVALATVFRGMYRRMVVPLGPLYSLPLPANREFNRALADLHLLV
                     DEIVAERRASGQKPDDLLTALLEATDENGDPIGEQEIHDQVVAILTPGSETIASTIMWL
                     LHMLAEHPEHADRVHDEVQAVTGGRPVAFADVRGLRHTNNVVVESMRLSPAVWILTRRA
                     VRDTELGGYRIPSGADIIYSPYAIQRDPKSYERNLEFDPDRWLPDRVKEIPKHAMSPFS
                     VGNRKCPSDHFSMAQLTLVTAALATRYRFEQVPGSKDATRVGITLRPHDLRVRPVPR"
     gene            complement(12466..13428)
                     /locus_tag="A4E84_RS26820"
                     /old_locus_tag="A4E84_26820"
     CDS             complement(12466..13428)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700022.1"
                     /locus_tag="A4E84_RS26820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26820"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_062928993.1"
                     /transl_table=11
                     /translation="MLQNVAVALLDGVNPFELGVVCEVFGTDRSDEGLPVYDFAVASAE
                     GPVLSMNSGFSLQAEHGLERLETADLIAVPAGHSYAYRDFPPELLDSLRRAVDRGARVL
                     SVCSGVFVLAAAGLLDGRRCATHWKHAKDLARQYPRVIVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRKEQGSEVANKIARRMVVPPHRDGGQAQYIERPLPHPEGDTIGDVLAWME
                     RHLDEEVTVEQLASHAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDETMD
                     AIAGRTGFGNAATLRHHFVRAIGTTPNSYRRTFRGPEAA"
     gene            13522..13764
                     /locus_tag="A4E84_RS43270"
                     /old_locus_tag="A4E84_26825"
     CDS             13522..13764
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047586.1"
                     /locus_tag="A4E84_RS43270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26825"
                     /product="hypothetical protein"
                     /protein_id="WP_062928994.1"
                     /transl_table=11
                     /translation="MNTNQIEALIGLTATFGILALLILPSVIGLVRERRIDRQIREAQE
                     AREGVPAQKSSSRSTVPSTATWYAEGRRSKKLVSS"
     gene            complement(13677..14684)
                     /locus_tag="A4E84_RS26830"
                     /old_locus_tag="A4E84_26830"
     CDS             complement(13677..14684)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657910.1"
                     /locus_tag="A4E84_RS26830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26830"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_062928995.1"
                     /transl_table=11
                     /translation="MSTQNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLHSD
                     VADLAKLSPAEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAV
                     HVQFYLTLLDTYLPDPEDRSAAFAAVENIPSIREKASFCFKWMDSVEKLDRLETQADRR
                     RFLLNLICFAACIEGLFFYGAFAYVYWLRSRGLLHGLATGTNWVFRDETMHMSFAFDVV
                     DTVRKEEPDLFDDRLQQEVTDMLREAVEAELQFARDLCGDGLPGMNTESMRQYLECVAD
                     QRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(14684..17041)
                     /locus_tag="A4E84_RS26835"
                     /old_locus_tag="A4E84_26835"
     CDS             complement(14684..17041)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="A4E84_RS26835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26835"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_062928996.1"
                     /transl_table=11
                     /translation="MTIAPAEEVSATEEAHDAPGAALLRTLTELTADLPDAEPGRVAAA
                     ALRGRSAAADEAELRELATEAAAGLISEDPAYSRLAARLLTIGIREEAASQGVTSFTES
                     VAAGHREGLIADRTAEFVRLHAARLDALIDTRADDRFGYFGLRTLHSRYLLRHPLTRKA
                     VETPQHFMLRVAAGLAEDDTRRSVDEVAALYRLMSRLDYLPSSPTLFNSGTRHPQMSSC
                     YLLDSPKDELDSIYDRYHQVARLSKHAGGIGLAYSRIRARGSLIRGTNGHSNGIVPFLK
                     TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWVPDE
                     FMRRVNADAQWSLFSPADVPELVDLWGEEFDAAYRAAEAKGLAKKTLPARELYGRMMRT
                     LAQTGNGWMTFKDAANRTANQTAEPGHVVHSSNLCTEILEVTSDGETAVCNLGSVNLGS
                     FVDTSTGDLDWERLDETVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMGLQDV
                     FFKLRLPFDSPQAKALSTRIAERIMLAAYEASADLAERNGPLPAWEKTRTARGVLHPDH
                     YDVELTWPDRWAALRERVATTGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRET
                     LSGEFLQVNSYLVDELKRLGVWDARTREALREASGSVQDFAWIPEDVRALYRTAWEIPQ
                     RGLIDMAAARTPFLDQSQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIA
                     RAARATVPVQATPDPEAVACSLENPESCEACQ"
     regulatory      complement(17164..17303)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17280..17293)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     misc_feature    complement(17287..17301)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    complement(17318..17332)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17425..19053)
                     /locus_tag="A4E84_RS26840"
                     /old_locus_tag="A4E84_26840"
     CDS             complement(17425..19053)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="A4E84_RS26840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26840"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_062928997.1"
                     /transl_table=11
                     /translation="MKDGVNGVALGVFIFFFLAVTVMGFLAARWRKAENEHSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVALTGILATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFIKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDDIFAKAGEAYSQTNPATGAPRGALTPAEPGQWTYATLALGSALALFMYPHSITATLS
                     SKSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGIKVQNGQLAIPQLFETMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPAQETKVSKLVSLLVKVGAL
                     AFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMVYGTVAAY
                     GVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVLNVVVTVVLTFVLRALKAPDGIDETKP
                     EDYTADAGDPGVKVELPPATAGSAH"
     gene            complement(19050..19316)
                     /locus_tag="A4E84_RS26845"
                     /old_locus_tag="A4E84_26845"
     CDS             complement(19050..19316)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992859.1"
                     /locus_tag="A4E84_RS26845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26845"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_079129129.1"
                     /transl_table=11
                     /translation="MSQAPEVSRGPVVTPMRVVIAVCLIAPFVAMLWVGSYAKTDPAFI
                     GIPFFYWYQMAWVLISTALTMIAYKLWQRDQRARSATKGGASQ"
     misc_feature    complement(19385..19399)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            complement(19460..20224)
                     /locus_tag="A4E84_RS26850"
                     /old_locus_tag="A4E84_26850"
     CDS             complement(19460..20224)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="A4E84_RS26850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_26850"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_062928999.1"
                     /transl_table=11
                     /translation="MSTDVSSAENENGVPVRTARVPKYYRLKKHLLDMTETQAPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYVTADDRLAGLLDITPGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SLDRDGQPVEWVRSVYRGDRYKFVARLKRPVD"
     misc_feature    20256..20271
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     misc_feature    20261..20279
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.03"
                     /tool="antismash"
     misc_feature    20285..20300
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.57"
                     /tool="antismash"
     misc_feature    complement(20453..20468)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.29"
                     /tool="antismash"
     misc_feature    20698..20707
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 gaggcaggtc aggcggcccc ggtcgacggt gaggacgagt ccctcggcgg cgtcctcgtg
       61 tttggggcgg atgttcgtcc ggggccgggt gttccggcgg cccggacggg tgcggatgtc
      121 gtcctcgtcg gtgtgcttgc cgtaacggcg catgacgtga tccctgcgtc ctacgccccg
      181 agcatcccgg tccacagatc ggggaagtcg ggcagggtct tggccgtcgt cgccacgttc
      241 tcgatctgca cgccctccac cgcgaggccg atgatcgcgc cggccgtggc catgcggtgg
      301 tcgtcgtagg tgtggaagat cccgccgtgc agccgccgcg ggcggatgtg cagaccgtcc
      361 gcggtctccg tgacgtcgcc gccgagttcg ttgatctcct tggtgagcgc ggccagccgg
      421 tccgtctcgt gcagccgcag gtgggccacg ccgcgcaggg tcgacgggga gtccgcgagg
      481 gccgcgaccg ccgcgatgcc cggcgtcagc tcgccgacct cgcccaggtc gacgtcgatg
      541 ccgtgcaccg agccggagcc ggtgaacacc agcccgtact cggtcagttc gcaggagccg
      601 cccatctcgg tgaagatctc gcgcagccgg tcaccgggct gcgtggtgcg ggagggccag
      661 tccgggacga cgaccttgcc gccggtcacc agcgccgccg ccaggaacgg ctgggcgttc
      721 gacaggtccg gctcgatgac caggtcccgg ccgagcaggg cgccgggcga gacccgccag
      781 acgttcggtt cgccgcccga ctcgggcgtg tccacctggg cgccgaccgc gcgcagcatg
      841 tcgacggtca tgcggatatg cggcatggag ggcagcgtgg cgccggtgtg gcggacctcg
      901 acgccctggt tgaagcgcgg cccggacagc agcagagagc tcacgaactg cgacgaggaa
      961 gaggcgtcga tggcgaccgt gccgccgtcc agggcgccgc tgccgtgcac ggtcaagggc
     1021 agcgcgccgc ggccgtcgtc gtcgatccgg gcgccgagct gccgcagcgc gtcgatgacg
     1081 ccgttcagcg gacgctcgta ggaacggggg tcgccgtcga accggacggg gccgtcggcg
     1141 agcgtggcga ccggcggcag gaaccgcatc accgtgccgg cgttgccgac gtcgaccgtg
     1201 gccgggccgc gcaggccggt ggggagcaca cgccaggcct cgccggtgcc gtccgggccg
     1261 acgccctcct cgatctcgat gcccagggcg cgcagcgcgc cggccatcag cagggtgtcg
     1321 cgggagcgca gggggcggcg cagccagccg ggctcggagg cgagggaggc gaggaccagg
     1381 gcgcggttgg tgaccgattt ggacccgggc acgtggaccg tcgcgtcgac ggctccgctc
     1441 gcgtgcgggg cgggccagag ggcggtgtct ggggtgttcg gggccatggc cccactttat
     1501 aagcaggccg tcgtccgagt gcggcgccgt ggggccggtc gcacccgcgt ggtggagccg
     1561 cgcagctcac aggccccacg cctcctcggg gcggccgtca cagctccagc agccagcgtc
     1621 ccccgccgat cagcgagcac agcgacaccg cgtggaacag gaagaaccag aggcccgccg
     1681 gcacgtgcgt cagccgcgac agctggtcgg cgtccgagtc cccggctccg ccccgggccc
     1741 gcttcgactg gagttcgaag gccgggcgta ctccgccgat cagcaggaac cacaccaccg
     1801 cgtacgcgaa cgccgcctgg acctgggggc cggccagcca ggacaccagc acgaacaggc
     1861 cgccggtgac gagcatggtc agggcgccgt aggcgttgcg gatcatcacg agcatggcga
     1921 ggagcagggc cgtggccagc cacagcagga gcgtgatccg gccggagccc agcagggagg
     1981 ccccgccgag gcccagcagg ggcggggcgg tgtatcccgc ggccgcggtg aggatcatgc
     2041 cgatgccgtg cggcttgccg cggctgacgg tcaggccgct ggtgtccgag tgcaggcgta
     2101 tgcccgtgag ggtgcggccg gtgagcaggg ccacgatccc gtgaccgccc tcgtgggcga
     2161 tggtgatcgc gttgcgggag atgcgccaca ggccgtgcgg gatcaccacg gcgagcgcgg
     2221 cgcccagggt cgcgatcacc acccacaggt cgggatcggg ctgcgtgccg gacacctcgt
     2281 cccagaggga ggcgagcgag gcggttgcgg tgctgtccat gtgtggcgtt ggctccctct
     2341 ggtgggatgg aatctggcag tgtggcacgt atgtgcggac ggtattcagc gagtcgtagg
     2401 ccagaggatc tcgcaggaat ctttgaggtc gagaagtggg agcccgagga gaccctcgcg
     2461 ccggactaca acgtggcgcc caccaaagag gtctacgccg tcctggaccg tcccctgaaa
     2521 gacgccgacg acccgcggcc ggttcggcag ctgcgcacgt tgaagtgggg gctcgtcccg
     2581 tcctggtcga agacccccga gggcggcgcc cggatgatca acgcccgcgc ggagaccgtc
     2641 cacgagaagc cgtcctaccg ccgtgccttc acctcccggc gctgcatcct gcccgccgac
     2701 ggctactacg agtgggtcac cggcacccag gagcgcgagc tggaggtcga gggcaagaag
     2761 aagcggcccc gcaagcagcc gtacttcgtg acaccggccg acgggtcggt cttcgcgatg
     2821 gccgggctgt acgagttctg gcgggacaag acgctgcccg acgaccaccc gcaggcctgg
     2881 tgggtgacgt gctcggtgat caccacggag gccgagcaga gcccgctcgc ggtgtccccg
     2941 gccgacgggc cgcgggcgct cgccgagatc cacccccgga tgcccctgat gctgacgccc
     3001 gaccgctggg acgcctggct ggacccctcc cgcacggacc ccgacggcct gcgcgagctg
     3061 ctcgccccgc cgcccgccgg gctgatgcgg gcctacccgg tcgccacggc cgtcagcaac
     3121 gtccgcaaca acgggccgga gctgctcaag gagctggaag gtcccgaaga gggcacactc
     3181 ttctgacgtg acgcatgtga cgaagaccgc cggcaccgcc accgagaccg tcgagaccga
     3241 cgccggaacc gcccgtatca cctggcacgg ggcgaagaag gcccggctgg tgctcgccgt
     3301 cagccacggc gcgggcggtg gcatcgaggc ccgtgacctg gtggcgctgg ccgaggtcct
     3361 gcccacccac ggcgtggccg tggcccgggt ggagcagccc tggcgggtgg ccgggaagaa
     3421 gctggcgccc gcgccgaaga ccctggacgc aggctggcgc ggcatctggc ccgccctggc
     3481 gaagtccgga ctgccggtga tctccggcgg gcgcagcgcc ggtgcccggg tggcctgtcg
     3541 caccgcgacc gagctgggtg cccacgccgt gctcgcgctc ggttttccgc tgcacccgcc
     3601 gggcaagccg gagaagtccc gcgccgagga gctgctggga gccggagtgc ccaccctggt
     3661 cgtgcagggc ggcaacgatc cgttcgggaa gccggaggaa ttccccgacg gggcgttcga
     3721 gctcgtggag atcccgtacg gggaccatgg cttcgccgtg ccgaagcgag cggacatctc
     3781 gcaggacgag gccgtgtctc tcatcacgga cgcggttgtg gagtggaccg ggtcactcgg
     3841 gtaaagcttc gggaatgccg gggcggcgat ccctgttgtg cgggacgtac gtgctggaga
     3901 ccagcaccga cgtcgtagga gaggaagtcc gccgcatggg ttcgaccatc tgcccgaccc
     3961 gcagcagccg cgccgacctg gactggacgg tgctgcacgc gggcaggacc gcccctgttc
     4021 gggcggcggg cggaccggat cgtcgtctat cctccgattc gggtgagacc ggtctcggtc
     4081 tcacgagaac attcgaggag gtgggtccgg tcactgggac cgacgcaggg accgaacacg
     4141 gccaggcgga gcagcccgag ggccggggcg gcacgggcgc ggagacggcc gcggagcgca
     4201 gcgcgcgctt cgagcgggac gcgctggagt tcctcgacca gatgtactcg gctgcgctgc
     4261 gcatgacgcg caacccggcc gacgccgagg acctggtgca ggagacgtac gccaaggcgt
     4321 acgcgtcctt ccaccagttc cgcgagggca ccaacctcaa ggcgtggctg taccggatcc
     4381 tcaccaacac cttcatcaac tcgtaccgca agaagcagcg cgaacctcag cgctccgcgg
     4441 ccgaggagat cgaggactgg cagctcgccc gcgccgagtc gcacatgtcg acgggcttgc
     4501 gctccgcgga gtcgcaggcg ctcgaccacc tgcccgactc ggacgtgaag gaggcgctcc
     4561 aggcgatccc cgaggagttc cgcatcgcgg tctacctcgc ggacgtcgaa gggtttgcct
     4621 acaaggagat cgccgacatc atggggacac ccatcggtac ggtgatgtcc cggctgcacc
     4681 ggggccgccg tcagctgcgc ggcatgctgg aggactacgc ccgtgaccgc gggatggtcc
     4741 cggccggtgc cggagagtcg aacgaagcga aaggctcggg gtcatgagct gcggagagcc
     4801 gcacgagacg gattgcagcg aaatcctcga tcatctctac gagttcctcg accgtgagat
     4861 gccggactcg gactgcgtga agttcgagca ccacttcgag gagtgctcgc cctgcctcga
     4921 gaagtacggg ctcgagcagg ccgtgaagaa gctcgtcaag cgctgctgcg ggcacgacga
     4981 cgtgccgggc gacctgcggg acaaggtcat ggggcggatc gagctgatcc gctccggcca
     5041 ggccgtcccc gagcaggacg tcacggcctc gcccgccacg tcccaggagt cctgacactc
     5101 ctgcgctttt caactacccc acctctgaac gggtagtcac tctcgaacac gtcactcgaa
     5161 cgtgctaatc cgcgggttat cggcccgcgg acccccctgc tgcggtccta ggctccgggc
     5221 ctgacggacg cggccggggg aggggctcat ggaagcggta ccggcacggg cacgtgtcta
     5281 catcgccggt gtcgccatgg ccgcgctgct ctgcctgctg ccgccgccgg gtgtacgcac
     5341 gccttggtgg gcggtcgcac tgctcgccgc gctgtacgcc ggctgcgagc gcgtcgcccg
     5401 gtgccggttc gtcgggatct cccacccggc cggcaccttc taccccgtac tgctcgccgg
     5461 tgccttcctg ctgccggcgc ccgccgcggc gctggtggtc gtgcccggcg cgctgctctc
     5521 acaggccggg cagcggcccg tggcgctgcg gcgcatctgg cgggccgccc agctcgtcct
     5581 cggcgtgtgg gccgccgcca cggtgcaccg gctgctcggc ggacgggacg cggtggccgc
     5641 gggcgacgtc ccgtacgcgc tcggtccggc gggggccgcc gtgctggcgt tctgcctggt
     5701 gctcgcgctg ctcgacggcg gcatcctggc cgcggcggag cgggtgcccg tgcggcgggc
     5761 ctggcggggt ctcgtggcgc gctcgctcgc gccgatcgcc gtgcacggcc tcgccggtct
     5821 gatgatggcg gtcctgtggc gcagccccta cggcccggtc gccgcgctgc tcgtgctgct
     5881 gcccatgtgc gtctcgtggt gggcgttcgc ccagtaccac cgggaacgcg ccgcccatca
     5941 ggcgaccatc cgggcgctgg tccaggccgt cgacatcaag gacgggtaca cccgcgggca
     6001 cagcgagcgc gtcgggcagg cctccatgat gatcgcccgt gagctgggca tggccgacga
     6061 gcgcgtggag gtgctccgct tcgccgggat cctgcacgac gtgggcaagc tgggcgtgcc
     6121 cacccgcctg ctcaggaagg acgggccgct cacgcccgag gagcggcggg tgatcgagct
     6181 gcaccccgag tacgggcacg agatggtgcg cggcatcggc ttcctcggcg aggcccgcgc
     6241 cgccgtgctg caccaccacg agcggctgga cggcagcggc tacccgtacg ggctggtggg
     6301 ccgtcagatc cccgagtccg cacgggtcgt ggcggtcgcg gacgccttcg acgccatgac
     6361 ctccacccgc agctacagca gggcccggcc cgtcgccgtg gccctggcgg agcttgagcg
     6421 gtgtgcgggc agtcacttcg acccggtgat ggtcgcggcg ctcgtcgaag ccgtcgggcg
     6481 gaccgggtgg caccccacgg tgaccgccga cgacgaggag acccgcccgg cccgggtgcc
     6541 cccgcccggc gcacccctgt ccagccgccc cggagcgcac cgatgagcgc gtaccggccg
     6601 ccacccctcc tcaccctcgt ccacgcctgc gccgccctgc tggccgccgg ctccctcgcc
     6661 gtcaccctcc accacggtct ggaggagcgc cgggtcgccc tggccttcgg cgtcctcgtc
     6721 accgtcggcg agctcactcg ccgcagcggc gcgcaggtcc gggaaccggc accgctcggc
     6781 gccgccgcgg ccctgtccta cgccctgctc ggagaggccg gcggacgggc cacccaccac
     6841 ggccccgccc aggtcgtcgc cgtggtgctg gccgcctcgc tgctcggcag cgtcccgcac
     6901 gtcgcacgcg ggcaggggcc caccctcgat cacctggcgc gccgcgtgct caccgtcggg
     6961 ttcgtcgccg tgtgcttcca gcctccgtac aaccggggca tgttcgacga ctggggcggc
     7021 cccgcctacg cgctgctgct gctcgcgctg ctgtcgctca ccgcgctgtg cgacgcggtg
     7081 ctcgccgccg ccctggccca cacccgcacc ggctggccct tcggtccggt gctgcgggac
     7141 gagctgcggg ccgtgtgcgg catcgggtcc gccgtcatcg ccaccggggc ggtgatggcg
     7201 ctggcggtcg ccgtcgtggg cctgtgggcc ctgccggtct tctccgtgcc gctgctgctc
     7261 gcccagatgt cgttccgccg ctatgccgcc gtccgggcga cctaccggca gaccatcgcc
     7321 tccctggccc gggccacgga ggtcgcgggc tacacgccgt gcgggcacgc ccggcgggtc
     7381 gccgctgtca gccaggcggt gggacgtgac ctggggctga ccgagcccga gctggccgtg
     7441 ctggagtacg ccgcgctcat gcacgacatc ggccagctga gcctcgtcga cccggtgccg
     7501 gcgggcgcca ccgccgcgct gcccgccgcg gagcagcggc ggatcgccct gctcggcggg
     7561 gcggtcgtcc ggcagacggg cgtcgacgag gcggtggccg tcgtcgtgga gcggcaggcc
     7621 gaccccttcg ccgagcagcc gctcgccgcg cgaatcgtcc gggccgtgaa cgcgtacgag
     7681 gagaagtccc gggaaggagg gcccggcggg ccgctgacgg cgctggagga actccggctc
     7741 gccaccgccg ggacgtacgc cccggaggtg gtggaatcac tggcccgcgt actggcaagg
     7801 agcagtctga ccctgcccgt ggctgggtaa cccatgggta atgagcgccc ttgaggccgt
     7861 acgtggttgg atgcgaagga gaaggtgtcc gggggctcga aacacagcta cggccagccc
     7921 accgcacgga actggcaggc gggaatcgtg aggatcttcg gcaagggacg gcaccggccc
     7981 tccgcctcct ggcggcaggc cacagaccgg gcgttcaccc tcatcggcga cggccgttac
     8041 gaggacgcgg gcgccctgct gacacgtgcc gccgatctgg agccctggct ttccgagtcc
     8101 tggttcaacc tcgcgctgct gcacaagttc cggcacgact gggagcaggc gcggacggcc
     8161 ggactcaggg ccgtggcgct gctcgaccgg gacaccggcg cgcccgactg gtggaacgtc
     8221 ggcatcgccg cgaccgcgct ccaggactgg ccactggccc ggcgcgcctg gcaggcctac
     8281 gggctgcggg tgccgggggc ggccaacgac tccggtgagc ctctcggcat ggacctcggc
     8341 agcgcggctg tacggctgtc cccggagggg gaggccgagg tcgtgtgggg acggcggctg
     8401 gatcccgcgc ggatcgaggt gctgtccatc ccgctgccgt cgtcggggcg gcgctggggc
     8461 gaggtcgtgc tgcacgacgg ggtgccgcac ggcgagcgga cgacggccgc cgggcacacg
     8521 tacccggtgt tcgacgagat cgagctgtgg gcgccgtcgc ccgtgccgac ctgggtggtg
     8581 ctgctggagg cggcgacgga ggcggaccgg gacgcgctgg agcagctggc ggccgacgcc
     8641 gggttcgccg cggaggactg gtcctcctcg gtgcggttgc tgtgccggat gtgctcggag
     8701 tcgcggatgc cgtccgatga aggcgacggg gagcatctcg atccgcacga tcacagtgag
     8761 ccggggcatc ccgggccgct ggggcaccgg acggatgggc agctgtgggt gccggagcgg
     8821 gagtgcgggc tggctgcgcc ggctgcgctg gtccgggggt tgctggacgg gtgggtggcg
     8881 gacagtccgg attctcggga ttggcgggat ctggaagagg tctgttagcg ccgttgccgg
     8941 gtgcggctgc gtcgtggttg ttcgcgcagt tccccgcgcc cccgaggggg cgccttcccc
     9001 gtaccctgta tcagcatccc gggttggatt tgttcaggaa ggcgtacgga cgtcatggct
     9061 cagcaggaca ccgatcagca gcacgcgggc gtgctccccg tcgatgacga ggggtatgtg
     9121 atcgacacgg agggctgcga ggagcgcgag gcggcctggc gggagcgggg gacctcgcgg
     9181 ccgatcacgg tggtcgggaa cccggtgctg cacaaggagt gcaaggacgt caccgacttc
     9241 ggcgacgagt tccagcagct cgtcgcggac atgttcgcca gccagcgcac cgccgagggc
     9301 gtgggcctgg ccgccaacca gatcggtgtc gacgcgaagg tcttcgtcta cgactgcccg
     9361 gacgacgagg gcgtccggca caccggcgtc gtctgcaacc ccgagctcgt ggaactgccc
     9421 gccgagaagc gccgcctgga cgacagcaac gagggctgcc tgtcggtgcc caccgcgtac
     9481 gcgccgctcg cccggcccga ctacgccgag gtgaccgggc aggacgagaa gggcaacccg
     9541 atccgggtgc gcggcaccgg gtacttcgca cgctgtttgc agcacgagac cgaccacctc
     9601 tacgggtacc tgtacatcga ccggctctcc aagcgcgagc gcaaggacgc gctgcggcag
     9661 atggccgaga acgagccccg ctaccccgtg gtggccaacg actgagacct cagccgcacc
     9721 cctcgcacgg cgtctgttcg ggttcaccac cctgaacagg cgccgttcct ctgtgccgtt
     9781 cgcctgtccg tcgcacgttc gatcgcttct gctctcctgg cgatccgtcg gcagtcacac
     9841 aacgggagat tcccggcact gcggggtagt gaatgaagca aatgcgttcc cagaacggtc
     9901 agttgtagtg ctgaatggga tgagcggggt atgcaacggc gcacgcccgg cacgaaggga
     9961 ggggcgcccg cgccaactgg cggctgagag gggttagttc gtgcatgctt tgtcacacgg
    10021 caccacaacg gcaccggcta cgatcgcagt tccaccgtcg ctctctctcc cggtgatcga
    10081 ggcggcgttt ccccggcaac tccacccgta ttggccgaag tgccaggaga agacgcgggc
    10141 ctggctgctc gaaaagcggc tcatgccggc ggacaaggtg gaggaatatg ccgacggact
    10201 ttgctacacc gacctcatgg ccgggtacta cctcggcgcc tccgacgagg tcatacaggc
    10261 gatcgccgac tacagcgcat ggttcttcgt ctgggacgac cgtcacgacc gcgacatcgt
    10321 gcacggtcgt ccggtcgcct ggcggctgct ccgggaccgg ctgcactcgg ccctcgactc
    10381 cccaggggag cacctgcacc acgaggaccc actggtcgcc gggttcgcgg acagcgtgct
    10441 gcggctgtac gcgttcctgc cccagacgtg gaacctccgg ttcgcccggc acttccacgc
    10501 ggtgatcgac gcgtacgacc aggagttcca caatcgcacc gagggaatcg tcccgacggt
    10561 cgaggaatac ctccggctgc gtcggctcac cttcgcgcac tggatctgga cggacctgct
    10621 ggagccgacc gccggatgtg aactacccga cgcggtgcgg aaacatccgg catatcggcg
    10681 ggcggcgctg ctgagtcagg aattcgccgc ctggtacaac gatctgtgct cgcttccgaa
    10741 agagatagcg ggcgacgagg tgcacaatct cggaatcagt ctcatcaccc atgaggggat
    10801 gaccctggaa cgggcggtcg cggaagtccg gcgccgtgtc gaggaatgca tcaccgactt
    10861 catccaggtc gagcgggagg cattgcggtt cgccgaagac ctcgccgacg gctccgtgcg
    10921 gggaaaggaa ctgagcgccg ccgtgcgggc ctgcctgagc aatatgcgga actggttcag
    10981 ttccgtgtac tggttccacc acgagtccgg ccgttacatg gtcgacagct gggacgaccg
    11041 gtccacgccc ccgtacgtca acaacgaagc ggcaggtgag aaatgaccgt cgagtctgtg
    11101 aagcccgaaa tcccgccggc cgtggaactg cgggagccgc cccgggcggg gggcggggtc
    11161 cccgtcctgg ggcacggctg gaggctcgcg cgcgacccgc tggcgttcat ggcacggctg
    11221 cgcgaccacg gcgacgtcgt acggctgaag ctcgggccga agacggtgta cgcggtcacc
    11281 accccggccc tgaccggcgc cctggcgctg agcaacgact tcatcatcgc cgggccgctg
    11341 tgggagtccc tggagggcct gctcggcaag gagggcgtgg ccaccgcgaa cggcccccgc
    11401 caccggcgcc agcggcgcac catccagccc gccttccggc tcgacgccat ccccgcctac
    11461 ggcccgatca tggaggagga ggcccacgcg ctgaccgagc gctggaaacc cggcgagacc
    11521 atcgactgca cctcggagtc cttccgggtg gccgtgcgca tcgcggcccg ctgcctgctg
    11581 cgcggcgact acatggacga gcgggcggaa cggctgtgcg tcgccctcgc caccgtcttc
    11641 cgggggatgt accggcggat ggtggtcccg ctcggaccgc tctacagcct gccgctcccg
    11701 gccaaccggg aattcaaccg ggcgttggcc gatttgcatc tcctcgtcga cgagatcgtc
    11761 gccgagcgcc gggcatccgg tcaaaagccg gacgatttgc tgacggcatt gctggaggcg
    11821 acggacgaga atggagaccc gatcggggaa caggagatcc acgatcaggt cgtcgccatc
    11881 ctgacccccg gcagcgagac catcgcctcc acgatcatgt ggctgttgca tatgctcgcg
    11941 gagcaccccg aacacgccga ccgggtacac gacgaagtgc aagcggtcac cggtgggagg
    12001 ccggtggcat tcgcagacgt ccgaggactc aggcacacca acaatgtcgt cgtcgagtcc
    12061 atgcgtttga gcccagccgt ctggattctc acgcgccggg cggtgcggga cacggaactc
    12121 ggtggatacc gtattccgtc cggggcggac atcatctaca gcccgtacgc gatccagcgc
    12181 gacccgaagt cgtacgagcg gaacctggag ttcgaccccg accgctggct tccggatcgg
    12241 gtcaaggaga tcccgaaaca cgccatgagc ccgttcagcg tgggcaaccg caagtgcccg
    12301 agcgatcact tctcgatggc ccagctgacg ctggtcactg cggccctggc caccaggtac
    12361 cggttcgagc aggtcccggg ctccaaggac gccacccgcg tcggcatcac gcttcggccg
    12421 cacgacctgc gggtgcggcc ggtgccgagg tgacggagga gggcttcagg ctgcttcggg
    12481 gcctctgaac gtccgccggt atgagttcgg cgtggttccg atcgcccgga cgaagtggtg
    12541 gcgcagcgtg gccgcgttgc cgaaccccgt tcggccggcg atcgcgtcca tcgtctcgtc
    12601 cgtcgcctcc agcagccgct gggccagcag cacgcgctgg cgcaggatcc agcggtaggg
    12661 agtggtcccg gtctcctgct ggaagcggcg ggcgaaggtg cgcggggaca tgtgggcgtg
    12721 ggaggcgagc tgctcgacgg tgacttcctc gtcgagatgg cgctccatcc acgccagcac
    12781 gtcgccgatc gtgtcgccct cggggtgcgg gagcgggcgc tcgatgtact gggcctggcc
    12841 gccgtcgcgg tgcggcggca ccaccatccg ccgggcgatc ttgttggcga cctcggagcc
    12901 ctgctccttg cgcaccaggt gcaggcaggc gtcgatgccg gcggccgtgc cggcggaggt
    12961 gatcaccggg tcctcgtcga cgtagaggac gtccggctcg acgatcacgc gcgggtactg
    13021 ccgggcgagg tccttggcgt gcttccagtg cgtggcgcag cggcggccgt ccagcagccc
    13081 ggccgcggcc agcacgaaga cgccggagca cacgctcagc acccgggcac cgcggtcgac
    13141 cgcacggcgc agggagtcca gcagctccgg ggggaaatcc cggtacgcgt aggagtggcc
    13201 ggccggcacg gcgatcaggt cagccgtctc cagccgctcc aggccgtgct cggcctggag
    13261 cgagaagccc gagttcatgc tcagaaccgg gccctcggcc gaggcgacgg cgaagtcgta
    13321 gaccggcaga ccctcgtcgc tccggtcggt gccgaagacc tcgcacacca cacccagttc
    13381 gaaggggttc acgccgtcga gcagggcgac ggccacgttc tgcagcatgc ctccagtgtg
    13441 cctcgccatt ggcagtaatt cgagggtcta cggcagtcct gccactgacg gtaaggagtc
    13501 atcggcgcga cagtggtgtc catgaacacg aaccagatcg aagcactcat cggactgacc
    13561 gccacgttcg ggatcctggc cctcctgatc ctcccgtccg tgatcggcct ggtgcgcgag
    13621 cggcgcatcg accgtcagat cagggaggct caggaggccc gggaaggtgt accggctcag
    13681 aagtcctcgt ccaggtcgac ggtgccctcc accgccacct ggtacgcgga gggccgccgc
    13741 tcgaagaagt tggtcagctc ctgaaccccc tggagctcca tgaaggagaa cgggttctcg
    13801 gagccgtaga ccggagcgaa gccgaggcgg gtgagccgct ggtcggcgac gcactccagg
    13861 tactgccgca tcgactcggt gttcatgccc ggcaggccgt ccccgcacag gtcccgcgcg
    13921 aactgcagct cggcctcgac ggcctcccgg agcatgtccg tcacctcctg ctggagccgg
    13981 tcgtcgaaga ggtccggctc ctccttgcgg acggtgtcga ccacgtcgaa ggcgaacgac
    14041 atgtgcatcg tctcgtcgcg gaacacccag ttggtgccgg tggccaggcc gtgcagcagg
    14101 ccccggctgc ggagccagta cacgtacgcg aaggcgccgt agaagaacag gccctcgatg
    14161 cacgcggcga agcagatcag gttgagcagg aagcggcggc ggtcggcctg ggtctccagc
    14221 cggtcgagct tctccaccga gtccatccac ttgaagcaga acgaggcctt ctcacggatg
    14281 gacgggatgt tctccacggc cgcgaaggcc gccgagcggt cctccgggtc gggcagatag
    14341 gtgtcgagca gcgtcaggta gaactggacg tgcacggcct cctcgaagag ctggcggctc
    14401 aggtagagcc gcgcctcggg ggagttgatg tgcttgtaca gcgtcagcac caggttgttc
    14461 gcgacgatcg agtcgcccgt cgcgaagaac gcgaccagcc ggccgatgag gtgctgttcc
    14521 gccggtgaca gcttggccag gtcggcgacg tccgagtgga ggtcgacctc ctccacggtc
    14581 caggtgttct tgatggcgtc ccggtagcgc tcgtagaagt ccgggtagcg catggggcgc
    14641 agggtgagct cgaagccggg gtcgagaagg ttctgggtgc tcattactgg caggcctcgc
    14701 aggactcggg gttttccagg gagcaggcga ccgcttcggg gtccggggtg gcctgcacgg
    14761 ggacggtggc ccgggcggcg cgggcgatgc gggtcgccgg gcgcgagcgc aggtagtacg
    14821 tggtcttcag cccggacttc caggcgtagg cgtacatcga ggagagcttg ccgatggtcg
    14881 gcgtctccag gaagaggttc agggactggg actggtccag gaacggggtc ctggccgccg
    14941 ccatgtcgat caggccgcgc tgcgggatct cccacgccgt gcggtagagg gcgcgcacgt
    15001 cctccgggat ccaggcgaag tcctgcaccg agccgctggc ctcgcgcagg gcctcccggg
    15061 tgcgggcgtc ccacacgccg agccgcttca gctcgtcgac caggtaggag ttgacctgga
    15121 ggaactcgcc cgacagcgtc tcgcgcttga acaggttgga cacctgcggc tcgatgcact
    15181 cgtacacgcc cgcgatggag gcgatcgtgg ccgtgggggc gatggcgagg agcagcgagt
    15241 tgcgcatacc ggtcgtggcg acgcgctcac gcagggccgc ccagcggtcc ggccaggtga
    15301 gctccacgtc gtagtggtcg gggtgcagca cgccccgggc cgtacgggtc ttctcccagg
    15361 cgggaagcgg tccgttgcgc tcggcgaggt cggcggaggc ctcgtacgcg gcgagcatga
    15421 tccgctcggc gatccgcgtg gacagggcct tggcctgggg tgagtcgaag ggcaggcgca
    15481 gcttgaagaa gacgtcctgg aggcccatgg cgccgaggcc gaccgggcgc cagcgggcat
    15541 tggagcggcc cgcctgctcg gtcgggtaga agttgatgtc cacgacccgg tcgaggaacg
    15601 tgacggccgt gcggacggtc tcgtccagtc gctcccagtc gaggtccccg gtcgatgtgt
    15661 cgacgaagga acccaggttg accgagccca ggttgcagac cgccgtctcc ccgtcgctgg
    15721 tgacctccag gatctccgtg cagaggttgg aggagtggac gacgtggccc ggctcggccg
    15781 tctggttggc ggtgcggttg gcggcgtcct tgaaggtcat ccagccgttg ccggtctgcg
    15841 cgagggtgcg catcatgcgg ccgtacagct cacgggcggg cagcgtcttc ttcgcgaggc
    15901 ccttcgcctc ggccgcccgg tacgcggcgt cgaactcctc gccccacagg tcgaccagct
    15961 cgggcacgtc cgcgggggag aacagcgacc actgcgcgtc cgcgttcacg cggcgcatga
    16021 actcgtccgg cacccagtgc gcgaggttca ggttgtgcgt gcggcgggcg tcctcgccgg
    16081 tgttgtcgcg cagttccagg aactcctcga tgtcggagtg ccaggtctcc aggtagaccg
    16141 cggcggcgcc cttgcggcgg ccgccctggt tcaccgcggc gaccgaggcg tcgagggtct
    16201 tcaggaacgg gacgatgccg ttggagtggc cgttggtgcc acggatcagg gaaccgcggg
    16261 cgcggatgcg ggagtacgcg agtccgatgc cgccggcgtg cttcgacagc cgggccacct
    16321 ggtgataccg gtcgtagatg gagtccagct cgtccttggg ggagtcgagg aggtagcagg
    16381 acgacatctg cgggtgccgg gtgcccgagt tgaagagggt gggggaggag gggaggtagt
    16441 cgaggcggct catgagccgg tagagcgcgg cgacttcgtc gacggagcgg cgggtgtcgt
    16501 cctcggcgag accggcggcg acccgcagca tgaagtgctg gggcgtctcg acggccttgc
    16561 gggtgagcgg gtggcgcagc agatagcggc tgtgcagggt gcgcaggccg aaatagccga
    16621 agcggtcgtc ggcgcgggtg tcgatgagcg cgtcgagccg ggccgcgtgc agccggacga
    16681 actcggcggt gcggtcggcg atgaggccct cgcggtggcc tgccgccacg gactcggtga
    16741 aggacgtgac gccctgcgag gcggcctctt cgcggatgcc gatggtcagc agccgggcgg
    16801 ccagccggga gtaggcgggg tcctcggaga tcagaccggc cgcggcctcc gtcgccagct
    16861 cccgcaactc cgcttcgtcc gcggcggcgg accggccgcg cagcgcggcg gcggcgaccc
    16921 ggccgggctc ggcgtcggga aggtcggcgg tcagctcggt cagggtccgc aacagcgcgg
    16981 cgccgggggc gtcgtgcgct tcttcggtgg ctgagacctc ttcggctggc gcgatggtca
    17041 cgtggggctc tccctcgctc ggcacggggc ctcgtcgagg gcaggcggca gcacgcgagc
    17101 gcacgcggcg tcgcgtccac cggcccattc cacgaggccc ggacgtcggg gcaccacggc
    17161 cgggtggccg ggtgcgctgc cgacaggtcc tcggactgac gcttgtgcac ggaacatgca
    17221 caagtacacc gttgcgggac agttccggat tcgcaccgga ttcccctgcg gcggcagcga
    17281 gcatgagcat acatcttgtg ttgggttccg acggcacccc cagatgttgt gtcggatacg
    17341 acagtgggcc gccgtgagga gtgctcacgg cggcccactg agggttgttc gtggttgatc
    17401 gcgcagttcc ccgcgcccct gaggctagtg cgcggaaccg gccgtcgcgg gcgggagttc
    17461 gaccttgacc cccgggtcgc ccgcgtccgc cgtgtagtcc tccggcttgg tctcgtcgat
    17521 gccgtcgggg gccttcaggg ccctcaggac gaaggtgagg accaccgtca ccaccacgtt
    17581 caggacgaac gccgtgaggc cgatgtagcc gatctccccg atgcccggga tctccttcgc
    17641 ggagccgccg aagtgcttct gggtcgggga ggccacgccg tacgcggcga ccgtgccgta
    17701 gaccatgccg accgcccagc ccgccagcag ggcccagcgg tggaaccagc gcgtgaacag
    17761 gccgccgacc agggccggga aggtctgcag gatccagatg ccgcccagca gctggaagtt
    17821 gatggcgacc gtcttgtcca tcgtgaggac gaaggccagg gcgccgacct tcaccagcag
    17881 cgacaccagc ttggagacct tggtctcctg cgcgggagtc gcgtccggct tgatgaagtc
    17941 cttgtagatg ttgcgggtga agaggttcgc ggccgcgatg gacatgatgg ccgccggcac
    18001 gagcgcgccg atgccgatcg ccgcgaacgc aacgcccgcg aaccagtccg ggaacatcgt
    18061 ctcgaacagc tgtgggatcg ccagctgccc gttctgcacc ttgatgccgg ccgcgatcgc
    18121 catgaacccg agcagcgcga gcagccccag catcagcgag tacagcggca ggatggtggt
    18181 gttgcgccgg atcacctcac ggctcttcga ggacagcgtc gccgtgatcg agtgcgggta
    18241 catgaagagg gccagggcgg agcccaacgc cagtgtggcg tacgtccact ggcccggctc
    18301 ggccggtgtc agcgcaccgc gcggcgcgcc cgtcgccggg ttggtctggc tgtacgcctc
    18361 accggccttg gcgaagatgt cgtcgaagcc gcccagcttg atcgggatgt agatgatcgc
    18421 caccgcgatg acgatgtaga tcagcgtgtc cttcacgaac gcgatgagcg cgggggcccg
    18481 cagacccgac gagtacgtgt acgccgccag cacgccgaac gcgatcagca gcggcaggtc
    18541 cttgatgaac cagttggtgt tctcgccgcc gccgacgccc atgacgtcca gcacggcctg
    18601 gatgccgacc agttggagcg cgatgtacgg catggtcgcg aggatgccgg tgagggccac
    18661 ggccagcgac aggcccttcg aaccgaagcg gccgcgcacg aagtcggagg tcgtgacgta
    18721 gccgtgcttg tgggacaccg accacaggcg ggggaggaag gtgaagatca gcgggtacac
    18781 caggatggtg tacggcaccg cgaagaagcc ggccgcgccc gccgcgtaga tcgccgccgg
    18841 cacggcgacg aaggtgtacg ccgtgtacag gtcgccgccg agcaggaacc aggtgaccca
    18901 ggtgccgaac gagcggccgc ccagccccca ttcgtcgagg ctgtgctcgt tctcggcctt
    18961 gcgccagcgc gcggccagga agcccatgac cgtgacggcc aggaagaaga agatgaagac
    19021 gccgagcgcg acgccgttca cgccgtcctt cactgcgacg caccgccctt cgtggccgag
    19081 cgggcgcgct ggtcacgctg ccagagcttg taggcgatca tggtcagggc ggtggagatg
    19141 agcacccacg ccatctggta ccagtagaag aacgggatcc cgatgaaggc cgggtcggtc
    19201 ttggcgtacg agccgaccca cagcatggcc acgaacggcg ctatgaggca gacggcgatg
    19261 acgacgcgca tgggcgtcac caccggccct ctgctgactt ccggtgcttg cgacatcagg
    19321 cggctccgtc cccttggtga tcacctgtag tgcgcaggca atctaggtca gggggcggcg
    19381 acagcggaac ccctcgtccg caatgcggta cccaaccgaa accaggcctc agcagcgccg
    19441 gaagctccgc cgatgcccct cagtcgacgg ggcgcttcag gcgggcgacg aacttgtagc
    19501 ggtccccccg gtacaccgac cgcacccact ccaccggctg gccgtcccgg tccagggagt
    19561 gacgggagag catcagcatc ggcaggccga cgtccgtgcc gagcaggccg gcctcgcgcg
    19621 gggtggccag ggacgtctcg atggtctcct cggcctccgc gaggtggacg tcgtagacct
    19681 cggccaacgc cgtgtagagg gacgtgtact tcaccagcga gcgccgcagc gcggggaagc
    19741 gcttcgcgct caggtgggtg gtctcgatgg ccatcggctc accgttggcc atacgcagcc
    19801 gctcgatgcg cagcacgcgc ccgccgggcg tgatgtcgag cagcccggcc aggcggtcgt
    19861 cggccgtgac gtagccgatg tccagcagtt gcgaggtggg ttcgagtccc tgggcgcgca
    19921 tgtcctcggt gtacgaggtc agttgcagtg cctgcgagac cttcggcttg gcgacgaagg
    19981 tgcccttgcc ctggatgcgt tccagccggc cctcgacgac cagctcctgc agcgcctggc
    20041 gcacggtcgt gcgcgaggtg tcgaactcgg ccgccagcgt gcgctcgggc gggaccggcg
    20101 tgcccggcgc ctgggtctcc gtcatgtcga gcaggtgctt cttcaggcgg tagtacttgg
    20161 gcacgcgtgc ggtacggacg ggcaccccgt tctcgttctc cgcactgctg acgtcggtgc
    20221 tcatgctccg ccttcccggc tgggtctgcc gacacgatcc cacttgtata ccgtcggcgc
    20281 ctcttttggt ctagtccacc attccctgtg gtctacccgc agtatgccgt gcccgccggg
    20341 gttttcgctg gcttcttact taaaggttcc tgcatatgta ggtcgcataa cggctggtca
    20401 gggctgtatc gggagccttg acaggtttcg tggtctggtc caagctcccc gtactggtct
    20461 acaccattgg tccaggcccg gccccacgtt cactgcgggg agccaggggg gttgtgggat
    20521 ccctgaggag ggtggcgtga agcgcaagct gatatccgcg atcggtatcg cgggcatgat
    20581 ggtctccatc gcggcgtgcg ggggcgaggg cgacgggggt tccgacaagg gcgcggacgc
    20641 caaggagctg accgtctggc tcaccgtcga cgcccagaac aactggcccg agctggtgaa
    20701 ggcggccgac gccgcggtgc agaagaagca ccccggcctc aagatcaacc acgagtacta
    20761 cggctggccc gacaagaacg ccaagctcga cgccgtcctc gccacggaca aggtccccga
    20821 cgtggtcgag atgggcaaca ccgagatgct cggctacatg gtcaagggtg ctttcgcccc
    20881 cctcgaccag gcgaaattcg acaactcgga tgcctggctg gacggcctca gggcctcggt
    20941 gacctacgac ggcaagacct acggtgtccc gtactacgcc ggcggccgcg tcgccaactg
    21001 gcgcaaggac gtggcggcgt cggtcggggt gaagtccgct ccgaagacgt acaaggagct
    21061 gaccaccgcc ctggacaaga tccaga
//
