LOCUS       NZ_CP015098            21008 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces qaidamensis strain S10 chromosome, complete genome.
ACCESSION   NZ_CP015098
VERSION     NZ_CP015098.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces qaidamensis
  ORGANISM  Streptomyces qaidamensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9083372)
  AUTHORS   Zhang,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-APR-2016) State Key Laboratory of Cryospheric
            Sciences, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 278x
            Sequencing Technology :: Illumina HiSeq 4000; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 10:55:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,226
            CDSs (total)                      :: 8,137
            Genes (coding)                    :: 7,871
            CDSs (with protein)               :: 7,871
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 266
            CDSs (without protein)            :: 266
            Pseudo Genes (ambiguous residues) :: 0 of 266
            Pseudo Genes (frameshifted)       :: 119 of 266
            Pseudo Genes (incomplete)         :: 213 of 266
            Pseudo Genes (internal stop)      :: 25 of 266
            Pseudo Genes (multiple problems)  :: 80 of 266
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:26:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1323252
            Orig. end                         :: 1344260
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21008
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11008](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11008
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    716..730
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     gene            1235..3274
                     /locus_tag="A4E84_RS05565"
                     /old_locus_tag="A4E84_05565"
     CDS             1235..3274
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (65-150). E-value:
                     2.6e-10. Score: 32.2. Matches aSDomain:
                     nrpspksdomains_A4E84_RS05565_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010045476.1"
                     /locus_tag="A4E84_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05565"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_062925470.1"
                     /sec_met_domain="PF00561 (E-value: 3.9e-06, bitscore: 25.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYVTNLPYETKEEEHVTIPMSDGIRLSAHIWRPTSSDQEPVPAV
                     LEYIPYRKRDLTAVRDSVHHPYLAGHGYACVRVDLRGTGDSEGVLRDEYLEREQADAEE
                     ILAWLAEQHWCDGGTGMMGISWGAFAALQVAARRPPSLKAIAIASFTDDRHADDMHYMG
                     GALLSDNLAEAGTMFAYGTCPPDPSVVGDRWRGMWHERLENTEPWVLEWLRHQRRDDYW
                     RHASVCEDYTSVRCPVLASSGWADGYSNAVTRLLGNLDVPRKGLIGPWSHKFPHLGEPG
                     PAIGYLQELVRWWDHWLKGVDNGVMDGPMLLAWMQDSVPPSTSYEERPGRWVGEPDWPS
                     PHIRPETRPLTRHTIGPAQDATAEPGEGGAAMTVRSPLSVGQFAGKWASYNAPPDLPYD
                     QREEDGGSLVFDSEPLTEPLEILGSPSVELDLTVSEPVALVAARLSDVSPDGAATRVSY
                     GILNLTRRDSTESPEPLEPGRRYRATIPLNGVAQAFPPGHRIRLSLSTSYWPLAWPAPK
                     PALLGVHEHSSTLTLPVRPVDEPDEVTSSPFGEPEGTPPLAMTQVTPPEERWDVKRDLI
                     DYRSELDIVKDRGTVRFEDIGLEAGRRAHERYTAVADDFTSVGGETTWTMRFRRDDWDV
                     RVVTSTRLTCDETDFFVDATLDAYEADRRVFSRTWNETVPRDLL"
     aSDomain        1430..1684
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4E84_RS05565_Abhydrolase_1.1"
                     /evalue="2.60E-10"
                     /label="A4E84_RS05565_Abhydrolase_1.1"
                     /locus_tag="A4E84_RS05565"
                     /protein_end="150"
                     /protein_start="65"
                     /score="32.2"
                     /tool="antismash"
                     /translation="PYLAGHGYACVRVDLRGTGDSEGVLRDEYLEREQADAEEILAWLA
                     EQHWCDGGTGMMGISWGAFAALQVAARRPPSLKAIAIASF"
     gene            3434..3838
                     /locus_tag="A4E84_RS05570"
                     /old_locus_tag="A4E84_05570"
     CDS             3434..3838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671070.1"
                     /locus_tag="A4E84_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05570"
                     /product="DUF779 domain-containing protein"
                     /protein_id="WP_062925471.1"
                     /transl_table=11
                     /translation="MTVRTGRVELTPAAEELLRRLTAAHGPVMFHQSGGCCDGSAPMCY
                     PRGEFRVGASDVLLGHVAGDTPFWMSADQFVYWSHTHLTVDVVPGRGSGFSLEAPEGVR
                     FLIRSRLLTDEELRRLDSEPPLPNGAAKSA"
     gene            3848..4318
                     /locus_tag="A4E84_RS05575"
                     /old_locus_tag="A4E84_05575"
     CDS             3848..4318
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557388.1"
                     /locus_tag="A4E84_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05575"
                     /product="SRPBCC family protein"
                     /protein_id="WP_062925472.1"
                     /transl_table=11
                     /translation="MYTSRVSGHVDAPRAAVYRALVSAEAIARWRVPDGMTGEVHEFDA
                     REGGGFRVSLTYEAPDASGKSAAHTDTYHGHFARLVPDEQVVEVLEFEAVDPALRGAMT
                     LTTTLTDAEGGGTDVVMVHEGIPDAVPAADNETGTRMALANLARLVEADGSS"
     gene            complement(4332..4961)
                     /locus_tag="A4E84_RS05580"
                     /old_locus_tag="A4E84_05580"
     CDS             complement(4332..4961)
                     /EC_number="5.4.99.5"
                     /GO_process="GO:0046417 - chorismate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115480.1"
                     /locus_tag="A4E84_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05580"
                     /product="chorismate mutase"
                     /protein_id="WP_062925473.1"
                     /transl_table=11
                     /translation="MRPRRLRCALTVLGAVATATALALGPAGPATAGTQRPAPASADRT
                     ATRHGLTSVTDLLAQRLLLADKVAAAKYGTDTPIDDPVREAQILDDVRARASALGLEPD
                     AVAAVFRDQIEANKLVQRALFARWDAHPGERPTERPDLAKEVRPALDRITTALLAALRD
                     TERTRALPSCGPRLATAAGWSAYTHRLDAPHLEGLGRALPSVCAGP"
     misc_feature    5153..5164
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.83"
                     /tool="antismash"
     gene            5313..8222
                     /locus_tag="A4E84_RS05585"
                     /old_locus_tag="A4E84_05585"
     CDS             5313..8222
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380243.1"
                     /locus_tag="A4E84_RS05585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05585"
                     /product="glycosyl hydrolase 115 family protein"
                     /protein_id="WP_079128877.1"
                     /transl_table=11
                     /translation="MAAAGAAPLLPVTAAEAAPSVRRPDFPLLRDGTAVDVFVDAADDP
                     AVIRAAGDLQADVERVGGVRPRLLHTVPPRAELLVVVGTIGASPVIDRLIAQRRLDVSR
                     VKGRWEASVTQVVDSPLPGVGRALVIAGSDRRGTVYGVYDTSERIGVSPWYWWADVPVV
                     RRDTVTVPAGPFVRREPAVRYRGVFINDEQNLTTWSRRTQEPDKNIGPKTYERVFELLL
                     RLKANYLWPAMHPYSDFFNKHRENPELAERYGIVVGSSHPEAMLRNGVHEWQPWAEEHR
                     NPDGTLPVYDYTVNPAVISDYWRARARQNAGYESSWTIGMRGLHDSALETKHATTVPEK
                     VAVMNDIIADQRRILAEEVGPAAEPQIFIPYKEVLELYNAGVEVPDDVTLIWPDDNHGN
                     MRQLPDESERRRPGGNGIYYHLSYWGRPRSYLWLDTTQLGKVWQELRRVHEHQADRMWI
                     FNVGDIKSIETGLSFCLDMAWDVDRWGPGDVEDFLVEWAGRQFGRRYGSEIAAIRTEYY
                     RLAAQRRPEFIDKAVFSTVHHGDEAGGRMTDYEQLLDRVRRLGAKLPEGYRDAYFQLVE
                     YPVHGAYLMNLKYYWADRNALAVRQGRGAGTNRFADLAEAAHAEEQAITRRYNTQIAGG
                     KWDGIVNPYPSEIPKAPGRPAVTRIPRQETSGLEVAAEGNETGAGRPLSFSSYTRDRRF
                     VDVFNTGFLPLEWRAEPSAPWIRLSTTGGELTDQVRVWAEIDWPRVPQGTHRPTLTFTG
                     AGRSLEVPLLVVDDGERARRRARGFVEAHGHVSIDAAHFDREVPRGGARWRTVRGLGRR
                     TAAVEAVPTTAPSITEDLTVRSPELRYRIRLTTAGTFPVTVFRLPSLDERGKRRVAVAL
                     DDQPPTVLSGQAIATGNRGDAWARNVEEGVEKLTARVTVAEPGEHVLRVFMVDPGMAVD
                     QIVIDTGGLPASHLAPPESYHRVFNPDPALAPGVAAQDR"
     misc_feature    complement(8292..8308)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.95"
                     /tool="antismash"
     misc_feature    complement(8343..8352)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.73"
                     /tool="antismash"
     gene            8533..10017
                     /locus_tag="A4E84_RS05590"
                     /old_locus_tag="A4E84_05590"
     CDS             8533..10017
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003894.1"
                     /locus_tag="A4E84_RS05590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05590"
                     /product="cytochrome P450"
                     /protein_id="WP_079128878.1"
                     /sec_met_domain="p450 (E-value: 5e-75, bitscore: 251.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGSVSGPARDWTVGTAPGIFPFIGHGIDLARRPLAFLNSLPEHG
                     DLVEIRLGPQRAWMACHPDLVHQVLMDPRTFDKGGPLYDRLRTLLGDGVGTCRHQDHRR
                     QRRLLQPEFRKARVADHVRLVGEEVESVCHAWRARQAVDISATMLDLSTRVVSRVLFSD
                     SLGTATAAEMRRCLATVVRGMFVRTVMPVDALFRVPTSANRRYRHASDRLRAIVDAAIA
                     RRRRNSPHDNRDDLLGTLLAATRADGGGTPITDREVHGQVMTLMFAGAESTALCLSSAL
                     ELLGRHPEEERRLHSEVDAVLASGQPPGSDELPRLVRTRCILTETLRHRPPGWLFTRVT
                     TQETELAGYRLPKGATVMFSPYLLHHDPTLFPDPDRFLPDRWLPGQAVAVPPGAMIPFG
                     AGSRKCIGETLALTEATVAVAFIARHWRLRHLPGHTERLHPAASLGPRGLVMVSEPRAG
                     RPVGTPPRADSRVPGTTAVPVVHDSRTAGGNDVRDA"
     misc_feature    8788..8790
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11008
                     /locus_tag="A4E84_RS05595"
                     /old_locus_tag="A4E84_05595"
     CDS             10001..11008
                     /EC_number="4.2.3.162"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988562.1"
                     /locus_tag="A4E84_RS05595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05595"
                     /product="(-)-alpha-amorphene synthase"
                     /protein_id="WP_062925476.1"
                     /sec_met_domain="T1TS (E-value: 3.3e-62, bitscore: 210.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATHEEVTLAAQDGIQVVDLREMIDANLYMPFPFQRSPHASAAA
                     AGVEEWLSTWGLTDNPAVAAMISCTRPAELAACNSPTMDPGLLQIVANQIAYQFIYDDR
                     AEDVGRHTPGRLLPMLCESIAILRDDQPPTTPLGAALADLHRQVRERCTPAQAARWAWN
                     SREYVHGLLYEAVAQNHPAPVGSGLCRSVRSLIAGVEPFYPLCEAAQPCELTPEEIHHP
                     VMRRLSRLSADAAVWIPDLFSAVKEQRAGGLINLALAYQRTHRCSLPTAVALATRHINS
                     TIREFERLYGEFRPELTPSGAGYVEGMAGWIRGCYFWSRTVPRYADALAAPPVL"
     misc_feature    complement(11208..11223)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.31"
                     /tool="antismash"
     gene            11216..14119
                     /locus_tag="A4E84_RS05600"
                     /old_locus_tag="A4E84_05600"
     CDS             11216..14119
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048705.1"
                     /locus_tag="A4E84_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05600"
                     /product="AAA family ATPase"
                     /protein_id="WP_062925477.1"
                     /transl_table=11
                     /translation="MAHGLRQSINEHRPLLERDEELRAGEHALARLRDTVDGVPQVPRG
                     GFLAFTGEAGLGKTTLIAAVRARAAALGFTVFSGKGGENEQGMAFRVVRQAMQPILARM
                     SETERRAFLSSWYDIVGAALGLEATDPARVPDPTGVRDGLDWVMTRLTMLNSPVVLLLD
                     DLHWADAESLDWLASFAPRVANLPLLIVVGYRPDELPSDATSFRMLVERHEQRPHVLSP
                     LGEAGVARIIRDEVGEEAEDEFCGACWTVTNGSPFEVVELAIRLRERKVRGTREELPVM
                     RDLAAAVKGPGLIERLKRLGPGTVRFAWAGAVLGGPFSPEDAADLAVVGREEAFEAAEK
                     LRVRRILADADEPAGNLEFVHPQIATTIYRDIPPALRVGMHNAAAHAAQAVGADPTVAA
                     RHLLEVPCDGRPEAVACLRAAAREYLRAGAPEAARRVLTRALREPPPAEDRAALLHELA
                     CSTFLIEPTATVSHLREALTEAGIDPDLRAAIVYRLTQALAHTDRMTEAATVAADEARR
                     ATNARVKLRMQADHFVWSAFRADEPDSSARSRRLARLADKLPGRSLEERYILGLRAWDA
                     LVRGEPRQTALGYAEEALRGGMSWTDENRGFEVPAAVALLFMYCDQPRRAEELFAEGMA
                     ECEHMGWRGSHLAQGQTLLGYIRYRRGFLPEAEELVRAGLHTAERVEGAVPAQWFAIGI
                     LIQTLLARGRTGDARRLADSYHYGDVVPNAVIFPDPRTVYADLLLAEGRLAQAARLLSK
                     VGDWLEGRDWRNPAWCPWQLGLASALARTAPDEAARHAQDAVKRARDFGAASAIGQALH
                     VQAEVTGGQAALDLHTQAVDHLERSPAAYELARALVGHGAALARNGHLHDAADRLYQGL
                     EGAVHCGAEGLAARARRELSAAGLRPLPLRYAQTDMLTAQERRAAEMTALGHPVSVVAK
                     DLRLTEQGVRQLLSAVYRKLGTDASGLPDALSNHPRR"
     misc_feature    complement(14278..14292)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     misc_feature    14279..14293
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     gene            14318..15397
                     /locus_tag="A4E84_RS05605"
                     /old_locus_tag="A4E84_05605"
     CDS             14318..15397
                     /EC_number="3.1.-.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012863.4"
                     /locus_tag="A4E84_RS05605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05605"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_237304852.1"
                     /transl_table=11
                     /translation="MQTIPHTFPRRFLPTLLAAALMACLLSWADGSPAQAALGGTATAK
                     AAAPGQPGDPNIKFVGRWDTTSSATAYTPYWAGAYYRAGFTGRTVKLKQRGTIDLWARI
                     DNGPVRFYDDVKGTVNLTPTALSPGNHTLQVNYQVVAGSYRGDAVFQGLVLDSGATTFA
                     PPAPAKLVEFVGDSITVGTTSSQNARTAYGWLIGERLGVEHTQIAQGGACLVAAADGCV
                     GLERQFTKLNPNAATPDWNFSRYRADAVVINLGTNDVGHGVSTAQFQSAYSSLLRKVRA
                     AYPQAWIFALETFRGRFVPQTEAAVRAAVAGGDARVSFVDTTGWLGSGDLSDSVHPNDR
                     GHRAIADRLAPVIAARIGA"
     gene            complement(15416..16897)
                     /locus_tag="A4E84_RS05610"
                     /old_locus_tag="A4E84_05610"
     CDS             complement(15416..16897)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474922.1"
                     /locus_tag="A4E84_RS05610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05610"
                     /product="MFS transporter"
                     /protein_id="WP_062925478.1"
                     /transl_table=11
                     /translation="MALLVIASCQLMVVLDITIVNIALPHIQNSLEFSTTSLSWVVNAY
                     TLTFGGLLLLGGRAGDILGRRRVFVFGVLLFVLASLLGGFAQNAGQLLGARALQGVGGA
                     IASPTALALISTTFREGPERNRAFGVFAAVSAGGGAIGLLAGGMLVEWLNWRWVLFVNV
                     PIGLLIVLATPRYIRESERHPGRFDVTGALTSTVGMVLLVYGFIRAAQEGWRDPLTLAS
                     FAGAVVILAVFVAIERRSKQPITPLHMFADRNRAGTYGIMLCLAAAIFGMFFFLTLFVQ
                     NVLGFSPLAAGLAFLPVSAVIAVGAGLASRFLPVYGPKPFMVVGAILAAAGLAWLTLTD
                     VHSTYAGSVLGPMLVFSLGMGMEFVSLTLMALSNVPTPETGAASGLLNATQQVGGSLGL
                     SILVTMYGTASTNEADKQIPDFLQQATPAERIRFERTGQLPKPWSDEILTAGVSAAFIM
                     AAIFTAVAALIALLVIQVRPSDLERLKGGAGPGPK"
     gene            17117..17722
                     /locus_tag="A4E84_RS05615"
                     /old_locus_tag="A4E84_05615"
     CDS             17117..17722
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115316.1"
                     /locus_tag="A4E84_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05615"
                     /product="response regulator transcription factor"
                     /protein_id="WP_063827555.1"
                     /transl_table=11
                     /translation="MIRVLLVEHTRLVRGAFAALLSREDDIEVVAEADGDGDVVARAVA
                     CRPDVAVIGVDSREGEEVAVRGELQARLPECRMLLMMASTTPERLRRLLDLHAAGVIST
                     NAPPDRLVHGVRKLVRGQRFVDPEFALAALDAGANPLTPREVEVLRLTADGTPTREIAE
                     RLCLSAATVRNHLSAITRKTGGRSRIDAVRIATESGWV"
     gene            complement(17987..19390)
                     /locus_tag="A4E84_RS05620"
                     /old_locus_tag="A4E84_05620"
     CDS             complement(17987..19390)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988565.1"
                     /locus_tag="A4E84_RS05620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05620"
                     /product="cytochrome P450"
                     /protein_id="WP_062931328.1"
                     /sec_met_domain="p450 (E-value: 5e-07, bitscore: 27.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESQRGDGGSVDLDGTSLETLAPEPLLTRDYEVRPALVYERLRQQ
                     HGPVAPVDLLGVPAWLVLGYRESLQVLQDDEGWPKGLENWRARTEGRVPSDWPLGPSLE
                     VNHILIQGGPGYRPLRTAWDVALKPFQDPRHPQAKRLKAAVTAYADELITLVGQGGATG
                     VADLSAQFSRPLPLMVASHLLGFPGSQGDDALMDMWRVLDAGPDAEAALERLLATLAEL
                     AALKLEKPGDDFPSYLLAAHPDLSLDQLARELFMLLGMTSDHVGILISNTVVEVLSGEG
                     SVRASLSAGMVRESMNRVVMRKPPLVNFVPRFAARDTQLGNYTIRAGDPVWVSPGAAHA
                     DPLFADHVASGTTISTRAHLSWGAGPRQCPARELASTVAAAGVGRLFERFDYLDLALPA
                     DQLPWRSSPFMRGLRSLPVRYELASVPPPRPWADVPAPGVAEEVLPDQAARQRSSLWRY
                     LTGLIRGGR"
     gene            complement(19525..20631)
                     /locus_tag="A4E84_RS05625"
                     /old_locus_tag="A4E84_05625"
     CDS             complement(19525..20631)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386469.1"
                     /locus_tag="A4E84_RS05625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_05625"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_062925479.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 8.2e-36, bitscore:
                     122.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYDGDVVVIGGGYAGVRLARRLDDTARVTLVDRKEVFFHRIASLR
                     AGVRPEWTHTPFIPYDRLLRHGRVATGKAVRIDTTERQVVLATGERLPYDVVVIATGAD
                     YPEPARFTGTTTEEAAKSFAEHQRNIATAEHVLVVGGGPGGVELSAEIRLARPEARVTL
                     AHSGPALLDSTGSARPGRKALAWLESHDVEVRLDSFMSPGNDFGTYRDARGTIIEADLS
                     FWATGTTPNTLWLRLAGHGDWLNGAGRVKVDRRLRVEGWPDVFAVGDVNDVSELKITPA
                     ALAQADIAAHNIRGYLQSSGKHRKEPRLYRPIQRTPLIVPFGPADGLTVLPVPGGESAV
                     LGSRTTTLTKAKSLMTPYMRRQLGYTAA"
ORIGIN
        1 tttcaccagc tgctgacgat cgaggagctt caggtcgggg aagtgcacct gcccacgctg
       61 ctcgacaagg cacagggcgt gctcgacgcg ttcgacggca gcatcgacgc gatcgtgggc
      121 tactgggact tcccggtcag caccctcgtc ccgatgctgg gcgagcgcta cggcacccgc
      181 agcaccagcc tggagtcggt ggtcaagtgc gagcacaagt actggagccg gctggagcag
      241 cagaaggtca ccgaccggca tccgcggttc ggccaggtcg acctgtcggc cgagccgccg
      301 cgcccgccgg aggacgtgac cttcccgatg tggctcaagc ccgccctgtc gtactcctcg
      361 gaactcgcct tcggagtcgg tgacgaggag gagttccaca aggccgtcgc cgagatccgc
      421 gacggcatat cccgcatcgg ccggcccttc gagcacatcc tcgaacgcat cgacctgccg
      481 ccggagatga acggtgtggg cggccgggtc tgcctggcgg aggagtcgat gtccggcgtc
      541 caggtggccg tcgagggcta tgtccaccag ggcgaggtga cggtctacgg ggtcctggac
      601 tccatccagt acccggactc ctcctgcttc ctgcgccacc agtacccctc gatgctgccg
      661 cccccggtca tcgcgcagct gcacgacgtc agcgagcgcg tgatgcggca gatcgggatg
      721 gactcggcca ccttcagcat cgagtacttc tacgaccccc ggtcccagga gatcaacctg
      781 ctggagatca acccgcggca ctcccagtcg cacgcggagc tgttccatta cgtcgacggc
      841 gtgcccaacc accactgcat ggtccgtctc gccctcggcg aggacccgca catgccgcac
      901 cgcgagggcg agtacgcgat ggcggcgaag tggtaccacc gctggttcac cgacggcgtg
      961 gtgcgccggg tgccgggccc cgaggagatc gcccgcatcg agcgggagac cccgggcgtg
     1021 cgcatcgagg tgattcccgc ggagggcgac aggctctcgg acctccccgg tcaggacagc
     1081 tacagctacg agctggcgca catctacacc ggcggcgcgg acgaggcgga gctgcgggcg
     1141 aagttcgacc actgcgtggc cgccctgggc ctggccttcg aggacgcccc ggccgaggcc
     1201 gacgcagccg agaagtgagg agcacgtggg ttccatgcgt tacgtgacca acctgccgta
     1261 cgagaccaag gaggaggagc acgtcacgat cccgatgtcc gacgggatcc ggctctccgc
     1321 gcacatctgg cgccccacct cctcggacca ggagccggtg ccggcggtgc tggagtacat
     1381 cccgtaccgc aagcgcgacc tgacggccgt acgggactcg gtccaccacc cctacctcgc
     1441 cgggcacggc tacgcgtgtg tccgcgtcga cctgcgcggc accggcgact ccgagggcgt
     1501 gctgcgcgac gagtacctgg agcgggagca ggcggacgcc gaggagatcc tggcctggct
     1561 ggcggagcag cactggtgcg acggcggcac gggcatgatg ggcatctcct ggggcgcgtt
     1621 cgcggcactg caggtggcgg cccgccggcc gccgagcctg aaggccatcg ccatcgcctc
     1681 gttcaccgac gaccggcacg ccgacgacat gcactacatg ggcggcgccc tgctgtcgga
     1741 caacctggcc gaggcgggca ccatgttcgc ctacggcacc tgcccgcccg acccgtccgt
     1801 ggtcggcgac cgctggcgcg ggatgtggca cgagcggctg gagaacaccg agccctgggt
     1861 gctggagtgg ctgcgtcacc agcggcgcga cgactactgg cggcacgcct cggtgtgcga
     1921 ggactacacg agcgtgcgct gcccggtcct ggcctccagc ggctgggcgg acggctactc
     1981 caacgccgtg acccggcttc tgggcaacct ggacgtgccc cgcaaggggc tgatcgggcc
     2041 ctggtcgcac aagttcccgc acctcgggga gcccggcccg gcgatcggct acctccagga
     2101 gctggtgcgg tggtgggacc actggctcaa gggcgtcgac aacggcgtca tggacggccc
     2161 catgctgctg gcgtggatgc aggacagcgt gccgccctcc acgtcctacg aggagcggcc
     2221 gggccgctgg gtcggcgagc cggactggcc atcgccgcac atccggcccg agacgcgtcc
     2281 gctcacgcgg cacacgatcg gacccgcgca ggacgccacg gccgagcccg gtgagggagg
     2341 cgcggccatg accgtgcgat cgccgctgtc cgtcggccag ttcgcgggca agtgggcctc
     2401 ctacaacgcg cccccggacc tgccctacga ccagcgggag gaggacggcg gctcgctcgt
     2461 cttcgacagc gaaccgctga ccgagccgct ggagatcctc ggctcgccga gcgtggagct
     2521 cgacctgacg gtcagcgagc cggtcgccct ggtggcggcg cggctgtccg acgtgagccc
     2581 cgacggggcc gctacccgcg tctcgtacgg catcctgaac ctgacccgcc gtgacagcac
     2641 cgaatcgccc gagccgttgg agccgggccg gcgctaccgg gccaccatcc cgctgaacgg
     2701 tgtggcgcag gcgttcccgc cgggccaccg catccggctg tccctgtcga cgtcctactg
     2761 gccgctggcc tggccggcgc ccaagccggc cctgctcggc gtccacgagc actccagcac
     2821 gctcaccttg ccggtgcggc cggtggacga gccggacgag gtgacgtcgt cgcccttcgg
     2881 cgaacccgag ggcactcccc cgctcgccat gacccaggtg acgcccccgg aggagcgctg
     2941 ggacgtcaag cgggacctga tcgactaccg ctccgagctg gacatcgtga aggaccgtgg
     3001 cacggtccgc ttcgaggaca tcggcctgga ggccggccgc cgcgcccacg agcgctacac
     3061 ggcggtcgcc gacgacttca cctcggtcgg cggcgagacc acgtggacca tgcggttccg
     3121 ccgggacgac tgggacgtac gggtggtcac cagcacccgg ctcacgtgcg acgagacgga
     3181 cttcttcgtc gacgcgaccc tcgacgcgta cgaggccgac cgccgggtct tctcccgcac
     3241 ctggaacgag acggttcccc gcgatctgct gtaggccagg tcgttggcgg tgagggtcgg
     3301 ggcaggcccc cggcggggcg ggagcgggca ggtgccgctc ccgcctgtgg cccccgcccg
     3361 cgcgcgggcg gatactggac gactcgcgat acggaccggt tcccggcctc gccgtcaccg
     3421 cctggaggaa cacatgaccg tgcgtacagg acgtgtcgaa ctgacccccg ccgccgagga
     3481 actgctgcgg cggctgaccg cggcgcacgg gccggtgatg ttccaccagt ccggcggctg
     3541 ctgcgacggc agcgccccga tgtgctaccc gcgcggcgag ttccgggtcg gcgcctcgga
     3601 cgtcctgctg gggcacgtgg ccggggacac cccgttctgg atgagcgcgg accagttcgt
     3661 gtactggtcg cacacgcatc tcaccgtgga cgtggtcccc ggccgcggca gcggcttctc
     3721 gctggaggcg ccggagggcg tccgcttcct gatccgctcc cgcctcctca ccgacgagga
     3781 actgcgccgc ctcgactcgg aaccgcctct gccgaacggg gcggccaaga gcgcctaggg
     3841 tgggcccatg tacacgtccc gggtctccgg ccatgtcgac gccccccgtg ccgccgtgta
     3901 ccgggcgctg gtgagcgccg aggcgatcgc gcgctggcgg gtgccggacg ggatgaccgg
     3961 cgaggtgcac gagttcgacg cccgcgaggg tggcgggttt cgtgtctcgc tcacctacga
     4021 agcgccggac gcctcgggga agtcggcggc gcacaccgac acctaccacg gccacttcgc
     4081 gcggctggtg ccggacgagc aggtggtcga ggtgctggag ttcgaggccg tcgaccccgc
     4141 gctgcgcggc gccatgacgc tgacgaccac gctgaccgac gcggagggcg gcggcaccga
     4201 cgtcgtcatg gtccacgagg gcatccccga cgccgtgccc gccgccgaca acgagacggg
     4261 cacgcgcatg gccctggcca atctggcccg cctcgtcgag gccgacggtt cttcctgaac
     4321 gacgggggct tctaggggcc ggcgcacacc gacggcagcg cccggcccag tccctccagg
     4381 tgcggggcgt cgagccggtg ggtgtacgcg gaccagccgg cggccgtggc cagacgcgga
     4441 ccgcacgacg gcagggcccg ggtccgttcc gtgtcccgca gcgcggccag cagcgcggtg
     4501 gtgatgcggt ccagggccgg gcggacctcc ttggccaggt cggggcgctc ggtggggcgc
     4561 tcccccgggt gggcgtccca acgggcgaac agagcgcgct gcaccagctt gttcgcctcg
     4621 atctggtccc ggaacaccgc ggccacggcg tccggttcga gcccgagggc ggatgcccgg
     4681 gcccggacgt cgtccaggat ctgcgcctcg cgcaccgggt cgtcgatcgg tgtgtccgtg
     4741 ccgtacttgg cggcggcgac cttgtcggcc agcagcagcc gctgggcgag caggtcggtc
     4801 accgaggtga ggccgtggcg ggtggccgtc cggtcggcgg aggcaggggc ggggcgctgg
     4861 gtgccggcgg tggccgggcc ggccgggccg agtgccagag cggtcgccgt cgccacggcg
     4921 ccgaggacgg tgagagcgca acggagacgt cgagggcgca ccgggttgac cttccgtggg
     4981 gggcgaggca agccccaacc taccgatcac cccgctgcgc gacgggtccg gctccgtcaa
     5041 gtggcgcggc acagcgggtc gtcggcgggg actgccgtga tggccgtggt gcctcagcgg
     5101 acccaccgcc cacatctgga cgccctcaca tggcctcgcc tagggtgcag cggcaagcgc
     5161 tttctagcct gcccatgcca accccctgtg cgcgcagccc cgccgacggc ccgtacgagg
     5221 aaccgccgcg gagccgacgc gcggaaaggc agtgcccagt gccgcagaga cagtcgttcc
     5281 cgtccgtgac ccgcaagtcc ttcttacggg ggatggcagc cgcaggcgcc gctcccctgc
     5341 ttcccgtcac cgccgccgag gccgccccct cggtccgccg ccccgacttc cccctgctcc
     5401 gggacggcac cgccgtggac gtgttcgtgg acgcggcgga cgaccccgcc gtcatccgcg
     5461 cggccggtga cctccaggcc gacgtggagc gcgtcggcgg cgtgcggcca cggctcctgc
     5521 acaccgtgcc accgcgcgcc gaactcctcg tcgtggtggg gacgatcggc gcgagcccgg
     5581 tgatcgaccg cctcatcgca cagcggcgcc tggacgtctc ccgggtgaag ggccgctggg
     5641 aggcgtccgt cacccaggtc gtggacagcc cgctgcccgg tgtggggcgc gccctggtca
     5701 tcgccggaag cgaccgccgc ggcacggtct acggcgtgta cgacacctct gaacgcatcg
     5761 gcgtatcgcc ctggtactgg tgggccgacg tccccgtggt ccgccgcgac acggtgacgg
     5821 tcccggcggg ccccttcgtc cgccgggagc ccgccgtccg ctaccggggc gtcttcatca
     5881 acgacgagca gaacctcacc acctggtccc gccgcaccca ggagccggac aagaacatcg
     5941 gcccgaagac ctacgagcgg gtcttcgagc tgctgctccg cctcaaggcc aactacctct
     6001 ggcccgcgat gcacccctac tccgacttct tcaacaagca ccgtgagaac cccgaactgg
     6061 ccgagcgcta cggcatcgtg gtcggctcca gccaccccga ggccatgctg cgcaacggcg
     6121 tgcacgagtg gcagccgtgg gccgaggagc accgcaaccc cgacggcacc ctgccggtct
     6181 acgactacac ggtgaacccg gccgtcatct ccgactactg gcgggcccgg gcccgccaga
     6241 acgccggcta cgagagcagc tggacgatcg gcatgcgcgg tctgcacgac tccgcgctgg
     6301 agacgaagca cgccaccacc gtcccggaga aggtcgcggt gatgaacgac atcatcgccg
     6361 accagcgccg catcctggcc gaggaggtgg gcccggcggc cgagccgcag atcttcatcc
     6421 cgtacaagga ggtcctggag ctgtacaacg cgggcgtcga ggtccctgac gacgtcacgc
     6481 tgatctggcc ggacgacaac cacggcaaca tgcgccagct cccggacgag tccgagcgcc
     6541 gccgccccgg cggcaacggc atctactacc acctctccta ctgggggcgc ccgcggagct
     6601 acctgtggct ggacaccacc cagctgggca aggtgtggca ggagctgcgc cgggtccacg
     6661 agcaccaagc ggaccgcatg tggatcttca acgtggggga catcaagtcg atcgagacgg
     6721 ggctgtcctt ctgcctggac atggcctggg acgtggaccg ctggggcccc ggcgatgtcg
     6781 aggacttcct cgtggagtgg gccgggcgcc agttcggccg gaggtacggc tcggagatcg
     6841 ccgcgatccg caccgagtac taccgcctgg cggcgcagcg gcgcccggag ttcatcgaca
     6901 aggcggtctt ctcgacggtg caccacggcg acgaggcggg cgggcgcatg acggactacg
     6961 agcagttgct ggaccgtgtg cgacggctgg gcgcgaaact gcccgagggc taccgggacg
     7021 cctacttcca gctggtcgaa taccccgtcc acggcgcgta cctgatgaac ctgaagtact
     7081 actgggcgga ccgcaacgcg ctcgccgtcc ggcagggccg cggcgccggc acgaaccgtt
     7141 tcgcggacct cgccgaggcg gcacacgccg aggagcaggc gatcacccgt cgctacaaca
     7201 cccagatcgc gggcggaaag tgggacggga tcgtcaaccc ctacccctcc gagatcccga
     7261 aggcgccggg ccgcccggcc gtgaccagga tcccccggca ggagacgtcg ggcctggaag
     7321 tggccgccga gggcaacgag acgggcgccg gccgcccgct gtcgttctcc tcctacaccc
     7381 gggaccgccg tttcgtggac gtgttcaaca ccggtttcct gccgctggag tggcgggccg
     7441 agccgagcgc cccgtggatc cggctgagca cgacgggagg agaactcacc gaccaggtac
     7501 gggtgtgggc cgagatcgac tggccgcgcg tgccgcaggg cacgcaccgt ccgacgctga
     7561 ccttcaccgg tgcgggccgg agcctcgagg tgccgctgct cgtggtcgac gacggggagc
     7621 gggcccggcg gcgggcccgc ggcttcgtcg aggcccacgg ccatgtgtcg atcgacgccg
     7681 cgcacttcga ccgcgaggtg ccgcgcggcg gggcgcgctg gcggaccgtg cgcgggctgg
     7741 gccgccgtac ggccgcagtc gaggcggtcc cgacgacggc cccgtcgatc accgaggacc
     7801 tcaccgtccg gtctccggag ctgcggtacc gcatccgctt gaccacggcc ggcacgttcc
     7861 cggtgacggt gttccggctg ccctccctcg acgaacgcgg caaacggcgc gtcgcggtcg
     7921 ccctcgacga ccagcccccg acggtcctgt cgggtcaggc gatcgccacc ggcaaccggg
     7981 gcgacgcctg ggcccgcaac gtggaggagg gcgtcgagaa gctgacggcc cgggtgaccg
     8041 tcgcggagcc cggtgagcat gtgctgaggg tgttcatggt ggatccgggg atggcggtgg
     8101 accagatcgt gatcgacacg ggtggtctgc ccgcgagcca tctcgcgcct ccggagagct
     8161 accaccgcgt cttcaacccc gaccccgccc tcgcaccggg cgtggcggca caggaccgat
     8221 aagccggtcg tcggcagtcg tctggccggc ctcggaccgc aatttcatgt ccatgccaga
     8281 cgcctgcccg atgccgcgtt cttcaggagc actgacggga acacggtctt ctgcgtgcac
     8341 ggtaaaacaa tagaaaactg accccatgca gcaaccgtga ttcgccgaac acccctccgt
     8401 gcatccgtgc gcccctacgg agaaaggatt cggcgagccg caggcagatt ccactgggca
     8461 ggacatgagg cgagcgtcaa ttcggtgcga ccgcatcaga attccgtgtg ccaactgagg
     8521 caggtggttt cgatgatcgg ctccgtttcc gggccagccc gggattggac agtgggcact
     8581 gctccaggca tattcccatt catcggccac ggtatcgact tggcccgtcg accgctggcc
     8641 tttctgaatt ctctgcccga acacggggat ctggtcgaga tacgcctggg tccgcagcgt
     8701 gcctggatgg cgtgtcaccc ggacctggtc caccaggtgc tcatggaccc gcgcaccttc
     8761 gacaagggcg gcccgctcta cgacaggtta cggacgctgc tgggggacgg cgtcggcacc
     8821 tgccgccatc aggatcaccg gcgccagcgc aggctgctcc agcccgagtt ccgcaaggcc
     8881 cgcgtcgccg accacgtgcg cctggtgggc gaggaagtgg agtcggtgtg ccacgcgtgg
     8941 cgggccaggc aagcggtcga catcagcgcg accatgctgg acctgtccac acgcgtggtc
     9001 agccgcgtcc tcttctccga ctcgctcggc accgcgacgg ccgccgagat gcgcaggtgc
     9061 ctggccaccg tggtccgcgg catgttcgtc cggaccgtga tgccggtcga cgccctgttc
     9121 cgtgttccca cgtcggcgaa ccggcgctac cggcatgctt ccgaccgcct gcgcgcgatc
     9181 gtcgacgcgg ccatcgccag gcgtcggcga aactctcccc acgacaatcg cgacgacctg
     9241 ctcgggaccc tgctggcggc cacgcgggcc gacggcggcg gaacgccgat caccgaccgg
     9301 gaagtccacg gccaggtgat gactctcatg ttcgccggcg ccgagagcac cgcgctgtgc
     9361 ctctcctccg ccctggagct cctggggcgg catcccgagg aggaacgccg cctgcactcc
     9421 gaagtcgacg ccgtgctcgc gtcagggcag ccgcccggct ccgacgaact gccacgcctc
     9481 gtccgcaccc gctgcatcct caccgagacc cttcgccacc gcccgcccgg ctggctcttc
     9541 acccgcgtca ccactcagga gacggaactc gccggatacc gtctgccgaa gggcgccacc
     9601 gtcatgttca gcccctacct cctgcaccac gaccccaccc tgttccccga tcccgatcgc
     9661 ttcctccccg accgctggct gcccggccag gccgtcgcgg ttccgcccgg ggcgatgatt
     9721 ccgttcggtg cgggcagccg gaaatgcatc ggagagacac tcgccctgac ggaggccacg
     9781 gtggccgtcg cgttcatcgc ccgccactgg cggctgcgtc atctgcccgg ccacaccgaa
     9841 cgcctgcacc ccgcggcgtc gttggggccg aggggactgg tgatggtcag cgaaccgcga
     9901 gcggggcggc cggtgggcac accgcctcgg gcggactccc gcgttcccgg gacaacagcc
     9961 gtacccgtcg tccacgactc ccgaacggca ggtggcaacg atgtccgcga cgcatgagga
    10021 agtcacgctc gccgcgcagg acggaataca ggtcgtcgat ctgagggaaa tgatcgacgc
    10081 gaacctctac atgcccttcc ccttccagcg cagtccccac gcgtccgcag cggcggcggg
    10141 cgtcgaggaa tggctgagca cgtgggggct gaccgacaac ccggcggtgg cggccatgat
    10201 ctcctgtaca cgccccgccg aactcgcggc ctgcaacagt ccgaccatgg accccgggct
    10261 cctccagatc gtggccaacc agatcgccta ccagttcatc tacgacgacc gcgcggagga
    10321 cgtcggccgg cacacgccgg gccggctgct gcccatgctg tgcgagagca tcgccatcct
    10381 gcgggacgac caaccaccca ccaccccgct cggggcggcc ctggccgacc tccatcgaca
    10441 ggtacgcgag cggtgcacac ccgctcaggc cgcacggtgg gcctggaaca gccgtgagta
    10501 cgtccacggc ctgctgtacg aagcggtggc ccagaaccat cccgccccgg tgggaagcgg
    10561 gctgtgccgg tccgtacgct ccctcatcgc gggcgtcgag ccgttctacc cgctgtgcga
    10621 ggccgcgcag ccgtgcgaac tgaccccgga ggagatccat caccctgtca tgcggcgcct
    10681 gagccggctg tcggccgacg cggcggtgtg gatacccgac ctcttctccg cggtgaagga
    10741 acagcgggcg ggcggcctga tcaacctcgc cctcgcctac cagcggacac accggtgctc
    10801 tttgccgacg gccgtcgcac tcgccacacg gcacatcaac agcacgatcc gcgagttcga
    10861 gcggctctac ggtgagttca ggccggagtt gaccccgtcc ggagccggct atgtggaggg
    10921 catggccggc tggatccgcg gttgctactt ctggtcccgc accgtgcccc ggtacgcgga
    10981 cgcgttggcg gcaccgcccg tgctctgatc cgctgcccga ccggtcgttt ccaccacagg
    11041 ggtcccgaga ggggcggaaa cgcagcagac tacccgaaag gctgaggctc gaaccgctcc
    11101 tgcgggaaat tcacccgctc cgcctacctc cacttccgac ccggccaagg ggcgtgcacc
    11161 aaggcgtacg ctcgccccgt ccggcgggga gcaacaacag gaagcggtag accacatggc
    11221 ccatgggctg cggcaatcga tcaacgaaca ccggccacta ctcgaacgtg acgaggaact
    11281 ccgagccggc gagcacgcgt tggcgcggct ccgcgacacg gtcgacggcg tgccccaggt
    11341 accgcgcggc gggttcctcg ctttcaccgg tgaggccggg ctgggcaaga cgacactcat
    11401 cgcggcggtc cgggcccgcg ccgccgccct cgggttcacc gtgttctccg gcaagggcgg
    11461 cgagaacgag caggggatgg cgttccgtgt cgtccgccag gccatgcagc ccatcctggc
    11521 caggatgagc gagacggagc gccgggcctt cctgagcagc tggtacgaca tcgtcggcgc
    11581 cgcgctcggt ctcgaggcga cggaccccgc ccgggtcccg gaccctaccg gagtacgcga
    11641 cggcctcgac tgggtcatga cgcgcctcac gatgttgaac tcgcctgtcg tgctgctcct
    11701 ggacgacctg cactgggccg atgccgaatc cctcgactgg ctcgcctcct tcgcgccccg
    11761 ggtcgcgaac ctcccgctgc tgatcgtcgt cggctaccgg cccgacgaac ttccgtccga
    11821 cgcgacctct ttccgcatgc tcgtcgagcg ccacgagcag cgcccgcacg tgctgtctcc
    11881 gctcggcgag gccggtgtgg cgcggatcat cagggacgaa gtgggtgagg aagccgagga
    11941 cgagttctgc ggcgcgtgct ggacggtcac caacggaagc cccttcgagg tcgtcgaact
    12001 ggccatccgg ctccgtgaac ggaaggtgag gggcacccgg gaggagttgc ccgtgatgcg
    12061 ggacctcgcc gccgcggtca agggccccgg cctgatcgag cgcctcaaac gcctcggccc
    12121 gggcaccgtc cgcttcgcgt gggccggcgc cgtcctgggt gggcccttct caccggagga
    12181 cgccgccgac ctcgcggtgg tcggcagaga ggaggccttc gaggcggccg agaagctgcg
    12241 cgtccgccgc atcctcgcgg acgccgacga gcccgcgggc aacctggagt tcgtccaccc
    12301 gcagatcgcc acgacgatct accgcgacat cccaccggcc ctgcgcgtcg gcatgcacaa
    12361 cgcggccgcc catgccgccc aggcggtcgg ggccgacccc actgtcgccg cccggcacct
    12421 gctggaggtt ccctgcgacg gccggcccga ggcggtcgcg tgcctgcgcg ccgccgcgcg
    12481 tgagtacctg cgcgccggag ccccggaggc cgcccgacgc gtgctgaccc gggcgctgcg
    12541 ggaaccgccc cctgccgagg accgcgccgc ccttctccac gagctggcct gctccacttt
    12601 cctgatcgag cccacggcca cggtcagcca tctccgggag gcgctgacgg aagcgggaat
    12661 cgatcccgac ctgcgcgccg ccatcgtcta ccggctgacc caggcgctgg cccacaccga
    12721 ccggatgacc gaggccgcga ccgtggccgc cgacgaggca cggcgcgcca ccaacgcgcg
    12781 cgtcaaactg cgcatgcagg ccgatcactt cgtatggagc gcgttccgcg ccgacgagcc
    12841 cgactcgtcc gcccgctcgc ggcggctggc gcggctggcc gacaagcttc ccggccgcag
    12901 tctggaggag cgctacatcc tcggactgcg ggcgtgggac gccctcgtgc gcggcgagcc
    12961 gcggcagacc gccctcgggt atgccgagga ggccctgcgc ggcgggatga gctggaccga
    13021 cgagaaccgc ggcttcgagg tgcccgcggc ggtcgccctg ctgttcatgt actgcgacca
    13081 gccgcggcgg gccgaagagc tcttcgccga aggcatggcc gagtgcgagc acatggggtg
    13141 gcgcggctcc catctggcgc agggccagac gctcctgggc tatatccgct accgccgcgg
    13201 tttcctgccc gaagcggaag agctcgtccg ggcggggctg cacaccgccg agcgcgtcga
    13261 aggagcggtg cccgcccagt ggttcgccat cggcattctc atccagaccc tgctggcccg
    13321 ggggcggacc ggtgacgcgc gccggctcgc cgacagctac cactacggcg acgtggtccc
    13381 caacgccgtc atcttccccg atccccgcac ggtgtacgcc gacctgctcc tggcggaggg
    13441 gcgactcgcc caggcggcgc ggctgttgtc caaggtcggg gactggctgg aggggcgcga
    13501 ctggcgcaac cccgcgtggt gcccctggca gctgggactg gcctcggccc ttgcccgcac
    13561 cgcccctgac gaggcggccc gccatgccca ggacgccgtc aagcgcgccc gggacttcgg
    13621 cgcggcgtcc gcgatcggcc aggcgctgca cgtccaggcg gaggtgacgg gcgggcaggc
    13681 cgcactcgat ctgcacacgc aggccgtgga ccacctggag cggtcgcccg ccgcgtacga
    13741 actggcccgt gccctggtgg gccacggcgc cgctctggcc cgcaacggtc atctgcacga
    13801 cgccgccgac cggctctacc agggcctgga aggtgcggtg cactgtggcg ccgagggcct
    13861 ggccgcccgc gccaggcggg agctctccgc ggcgggactg cgtccgctgc ccctgcgtta
    13921 cgcgcagacg gacatgctga cggcccagga gcgcagggcc gccgagatga cggccctggg
    13981 ccacccggta tcggtggtgg cgaaggacct gcggctcacc gagcagggcg tacggcaact
    14041 gctgtccgcc gtgtaccgaa aactcggcac ggacgcatcc ggcctccccg acgccctgtc
    14101 gaaccatccc cgacggtgac ggccgggagc ccggccaccc acccaggctg gcagccatgg
    14161 gggttcgcgg cgtcacccgg ccgtgcggcg atcggagcac gcagcggccc tcccccttcc
    14221 ataccgtccg ctgtcttgac gctgaaccgt ttcactgctt ccctcgaaag gctgccgatg
    14281 ggagcgctcc caccccaccc cacgtgaagg gaaccccgtg cagaccatcc cccacacctt
    14341 cccgagacgt ttcctgccga ccttgctggc ggccgcgctc atggcctgtc tgctgtcctg
    14401 ggccgacggc tcgcccgcgc aggccgccct cggcggtacc gccacggcga aggcggccgc
    14461 ccccgggcag cccggtgacc cgaacatcaa gttcgtcggc cgctgggaca ccaccagctc
    14521 cgccaccgcc tacaccccgt actgggcggg cgcgtactac cgggccggct tcaccggccg
    14581 cacggtcaag ctgaagcagc ggggcacgat cgacctgtgg gcgcggatcg acaacggccc
    14641 cgtgaggttc tacgacgacg tcaaggggac ggtgaacctg accccgacgg ccctgtcccc
    14701 cggcaaccac accctccagg tcaactacca ggtggtggcc gggtcgtacc ggggggacgc
    14761 cgtcttccag ggactggtcc tggacagcgg cgcgacgacg ttcgccccac cggccccggc
    14821 gaaactggtc gagttcgtcg gcgactccat caccgtgggc acgacgagct cgcagaacgc
    14881 ccgtaccgcg tacggctggc tgatcgggga gcggctgggc gtcgagcaca cgcagatcgc
    14941 ccagggcggg gcgtgcctgg tggccgcggc ggacggatgc gtggggctgg agcggcagtt
    15001 caccaagctc aacccgaacg cggcgacgcc cgactggaac ttctcgcgct accgggccga
    15061 cgcggtcgtc atcaacctcg gcaccaacga cgtcgggcac ggggtgagta cggcacagtt
    15121 ccagtcggcg tacagcagtc tgctgcgcaa ggtgcgggcc gcgtatccgc aggcgtggat
    15181 cttcgcgctg gagacgttcc gcgggcggtt cgtcccccag accgaggccg cggtgagggc
    15241 cgccgtcgcc gggggtgacg cgcgggtgtc cttcgtcgac accaccggct ggctggggtc
    15301 gggcgatctg tcggactcgg tgcatcccaa cgaccggggg caccgggcca tagccgaccg
    15361 gctggcaccg gtgatcgcgg cgaggatcgg ggcgtagcgg ctccaggggc gggcctcact
    15421 tcgggccggg gcccgctccg cccttgaggc gttcgaggtc cgagggccgg acctggatga
    15481 cgagcagggc gatcagggcg gctacggcgg tgaagatcgc cgccatgatg aaggcggccg
    15541 agacaccggc ggtgaggatc tcgtcggacc agggtttggg cagttgcccg gtgcgttcga
    15601 accggatgcg ctcggctggg gtcgcctgct ggaggaagtc cgggatctgc ttgtccgcct
    15661 cgttggtgct ggccgtgccg tacatcgtca ccaggatgga cagtccgagg gagccgccga
    15721 cctgctgggt ggcgttgagg agtccggagg ccgcgccggt ctccggcgtg ggcacgttgg
    15781 acagcgccat gagggtcagt gacacgaact ccatgcccat gcccaggctg aagacgagca
    15841 tcggtccgag gacactgccc gcgtaggtgg agtggacgtc ggtgagggtc agccaggcca
    15901 ggcccgccgc cgccaggatc gcgcccacca ccatgaacgg cttgggcccg tagacgggca
    15961 ggaaccgcga ggccagaccg gcgcctacgg cgatgaccgc gctgaccggc aggaaggcga
    16021 ggccggccgc gagcgggctg aacccgagca cgttctgcac gaagagtgtg aggaagaaga
    16081 acatgccgaa gatggctgcg gccaggcaca gcatgatgcc gtaggtgccc gcgcggttgc
    16141 ggtcggcgaa catgtgcagc ggcgtgatgg gctgtttcga acgccgctcg atcgcgacga
    16201 agaccgccag gatcacgacc gctccggcga acgaggcgag cgtgagcggg tcccgccagc
    16261 cctcctgcgc ggctctgatg aagccgtaga cgagcagcac catgcccacg gtggaagtga
    16321 gcgcgccggt gacgtcgaag cgcccggggt ggcgttcgga ctccctgatg taacgcggtg
    16381 tggcgagcac gatgagcagg ccgatgggca cgttgacgaa cagcacccac cgccagttca
    16441 gccactccac cagcatgccg ccggcgagca ggccgatcgc gccgcccccg gccgagaccg
    16501 cggcgaagac gccgaaggcg cggttgcgtt ccggtccctc gcggaaggtg gtgctgatca
    16561 gggcgagcgc ggtcggggag gcgatggcgc cgccgacgcc ctgcagggca cgggcgccga
    16621 ggagttggcc ggcgttctgg gcgaatccgc cgagcaggga ggcgagcacg aagagcagca
    16681 cgccgaagac gaagacgcgc cgcctgccga gaatgtctcc ggcccggccg ccgagcagca
    16741 gcaggccgcc gaaggtgagg gtgtaggcgt tcaccaccca ggacaggctc gtggtggaga
    16801 actccagtga gttctggatg tgcggcagcg cgatgttcac gatggtgatg tcgaggacca
    16861 ccatcaactg gcacgaggcg atgaccagca gcgccatcgc gttgccgcca ccaccgggtt
    16921 ccctggtggt ggtcgcctgt ggtgaggccg gctgcgggct gctgcctgcg gtgtccaccg
    16981 ttcgacggta cgcccggctc ccaggcctca ccactcgatc agtcgtgccg tggcccgacc
    17041 tgaaaaaccc gcggagtgcg gcgataatcc gttcaaggtg gccctgcggg ccacgtacgg
    17101 cggagaggga gcgaccgtga tccgcgttct tctcgtcgag cacacccgtc tcgtgcgggg
    17161 agcgttcgcc gctctgctgt cgcgggagga cgacatcgag gtcgtcgcgg aggccgacgg
    17221 cgacggcgac gtggtcgcgc gcgccgtggc gtgccggccg gacgtggcgg tgatcggcgt
    17281 ggactcccgg gagggcgagg aggtcgccgt ccggggtgag ctgcaagcac ggctcccgga
    17341 gtgccggatg ctgctgatga tggcctcgac gacgcccgaa cggctgcgtc gcctgctcga
    17401 tctgcacgcc gccggggtca tcagcaccaa cgccccgccg gaccggctgg tccacggcgt
    17461 ccgcaagctg gtgcgggggc agcggttcgt cgaccccgag ttcgcgctgg ccgcgctgga
    17521 cgcgggagcc aacccgctga ccccgcgcga ggtggaggtg ctgcggctga cggccgacgg
    17581 tacgcccacg cgggagatcg ccgagcggct gtgcctgtcc gccgccacgg tccgcaacca
    17641 tctgtcggcg atcacccgga agacaggcgg ccgcagccgg atcgacgcgg tccggatcgc
    17701 cacggagtcg ggctgggtgt gagccccgcg cccccgttca cgccctgctt ccgccccgtc
    17761 ccgcccccgt cccgcgccct gacggcggaa cggccgggca ggtcatcgag gtgtacctgc
    17821 ccggcccccg cgggccctcg cgccctgtcc cgggatctgt cacgagcatc gcagagcggg
    17881 cgccccttgg accagcacct ttcgtcacgt gtgcggcgtg aaagcgtcat cccggggccg
    17941 tgacgaacgc cggtgcggga taggcgttcg actcggtcct tccaggtcag cgaccgccac
    18001 ggatgaggcc cgtcagatag cgccacagcg aggaacgctg ccgcgcggcc tggtccggga
    18061 gcacctcctc ggccacaccc ggggcgggga cgtccgccca gggccgaggg ggcggcacgg
    18121 aggcgagttc gtaccgtacg ggcagggaac gcaggcctcg catgaacggc gaggagcgcc
    18181 acggcagttg gtcggcgggc agggccaggt cgaggtagtc gaaccgctcg aacaggcgcc
    18241 ccacaccggc cgccgcgacg gtcgaggcga gctcccgcgc cgggcactgg cgcggtccgg
    18301 ctccccagga caggtgggcc cgggtgctga tggtggtgcc cgacgcgacg tggtcggcga
    18361 agagcgggtc ggcgtgcgcg gcgcccgggg agacccacac gggatcaccc gcccggatgg
    18421 tgtagttgcc gagctgggtg tcccgggcgg cgaagcgcgg gacgaagttg accaggggcg
    18481 gcttgcgcat gaccacccgg ttcatgctct ccctgaccat gccggcggac aggctggcgc
    18541 gcacgctgcc ctcgcccgag aggacctcca cgacggtgtt ggagatgagg atgccgacgt
    18601 ggtcggaggt catgcccagc agcatgaaca gctcgcgggc gagctggtcg agcgacaggt
    18661 ccgggtgggc ggccagcagg tacgagggga agtcgtcgcc cggcttctcc agtttcagcg
    18721 cggccagttc ggccagcgtc gccagcaggc gttccagtgc ggcctcggcg tccgggccgg
    18781 cgtcgagcac gcgccacatg tccatgagcg cgtcgtcgcc ctgcgagccg gggaagccca
    18841 gcagatggct ggccaccatc agcggcagcg ggcgggagaa ctgcgcggac aggtccgcaa
    18901 cgccggtcgc gccgccctgc ccgacgaggg tgatcagttc gtcggcgtag gcggtgacgg
    18961 cggccttcag acgcttggcc tgcgggtggc gggggtcctg gaagggcttc agggcgacgt
    19021 cccacgcggt gcgcagcggc cggtagccgg ggccgccctg gatcaggatg tggttgacct
    19081 ccagggaggg ccccagcggc cagtcggacg gcaccctgcc ctcggtgcgg gcccgccagt
    19141 tctccaggcc cttgggccag ccttcgtcgt cctggagcac ctggagcgac tcccggtagc
    19201 cgaggaccag ccaggccggc acccccagca gatcgaccgg cgcgaccggg ccgtgctgct
    19261 ggcgcagccg ctcgtacacg agcgcgggcc gcacctcgta gtccctggtc agcagcggtt
    19321 cgggagcgag tgtctccagg ctcgtgccgt ccaggtccac ggatccgccg tcaccccgct
    19381 gggattccat cgtcttgcca ccctccgaca cgccctgtac cggcacacca tcagccggta
    19441 gccggaaacg gtggggaccc taccccagac cgaacccgcg ggtaacggcc gggggtgggg
    19501 tggtgacgac ggcgaggccg cgggtcaggc ggccgtgtaa ccgagttgac ggcgcatgta
    19561 gggcgtcatg aggctcttcg ccttggtcag ggtggtggtg cggctgccga ggacggcgga
    19621 ctctccgccc ggcacgggca gtacggtcag tccgtcggca gggccgaagg gcacgatcag
    19681 cggggtgcgc tggatcgggc ggtacaggcg cggctccttg cggtgtttgc cggaactctg
    19741 caggtagccg cggatgttgt gggcggcgat gtccgcctgg gcgagtgcgg cgggggtgat
    19801 cttgagttcg ctgacgtcgt tcacgtcgcc gacggcgaac acgtccggcc agccctcgac
    19861 ccggagcctg cggtcgacct tcacgcgccc ggctccgttg agccagtcgc cgtggccggc
    19921 caggcgcagc cagagcgtgt tgggggtggt gccggtcgcc cagaaggaca ggtcggcctc
    19981 gatgatcgtg ccgcgggcgt cgcggtaggt gccgaagtcg ttgcccggcg acatgaagga
    20041 gtcgagccgt acctccacgt cgtgggactc cagccaggcc agggccttgc gtcccggacg
    20101 ggcactgccc gtggagtcca gcagggcggg cccggagtgg gcgagggtga cgcgggcctc
    20161 cgggcgggcg aggcggatct cggcgctgag ttcgacgccg ccggggccgc cgccgacgac
    20221 caggacgtgt tcggccgtgg cgatgttgcg ctggtgctcg gcgaaggact tggccgcttc
    20281 ctcggtcgtg gtgccggtga agcgggccgg ctcggggtag tcggcgccgg tggcgatcac
    20341 gaccacgtcg tacggcagcc gctcgccggt ggcgaggacg acctgccgct cggtggtgtc
    20401 gatgcggacg gccttgccgg tggccacccg gccgtggcgc agcagccggt cgtaggggat
    20461 gaagggggtg tgcgtccact cggggcgcac tcccgcgcgc agggaggcga tgcggtggaa
    20521 gaagacctcc ttgcggtcca ccagcgtgac ccgggccgtg tcgtccagcc gtctggccag
    20581 ccggacaccg gcatagccgc cgccgatcac cactacgtcg ccgtcgtaca caaccgggtc
    20641 tcctgtgctg ggggggaacg agggccgccg cggacgggcc ccgctcggat cgacccccgg
    20701 cggccactcg actgacgcga cagtagccct tgaaagttaa agggatcccg aggttccgtg
    20761 catgttccgt gaagggatcg gcacctgacc ggccgtcacc tcccccagat cttccggtag
    20821 tcctcgcggt agcccgaggg gtcccagctg gtggcgccct cgctgttgcc cgccgtggcg
    20881 atgtgcacgg gggccacgta cccgctgtcg ggacggccgg agaaggcgcg gttgaactcg
    20941 tcgacgatct gccagccctg cagggacagc ggctcgggca cggtggcggc ctggtactgc
    21001 cgggcgtt
//
