LOCUS       NZ_CP015098            11380 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces qaidamensis strain S10 chromosome, complete genome.
ACCESSION   NZ_CP015098
VERSION     NZ_CP015098.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces qaidamensis
  ORGANISM  Streptomyces qaidamensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
REFERENCE   1  (bases 1 to 9083372)
  AUTHORS   Zhang,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-APR-2016) State Key Laboratory of Cryospheric
            Sciences, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 278x
            Sequencing Technology :: Illumina HiSeq 4000; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 10:55:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,226
            CDSs (total)                      :: 8,137
            Genes (coding)                    :: 7,871
            CDSs (with protein)               :: 7,871
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 266
            CDSs (without protein)            :: 266
            Pseudo Genes (ambiguous residues) :: 0 of 266
            Pseudo Genes (frameshifted)       :: 119 of 266
            Pseudo Genes (incomplete)         :: 213 of 266
            Pseudo Genes (internal stop)      :: 25 of 266
            Pseudo Genes (multiple problems)  :: 80 of 266
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:26:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 310950
            Orig. end                         :: 322330
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015098.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11380
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11380
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11380
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6380](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6380)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(363..2105)
                     /locus_tag="A4E84_RS01290"
                     /old_locus_tag="A4E84_01290"
     CDS             complement(363..2105)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004121.1"
                     /locus_tag="A4E84_RS01290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01290"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_062924762.1"
                     /transl_table=11
                     /translation="MSTVAADADAPARGALRALLPALAEHRAMTARTCAAALLEQGSLV
                     ALLTLAAHTVGAAVIDERAPAAGTVTALVVLVALRALMTWREMDLSHDLAYRVLAALRV
                     RVFDGLARSAPARVAGRRSGDLAATAMADVEALEFFYAHTTAQLLAAGTVFTGGSAVLA
                     LVEPWLLAAVMPVAVLLAAAPFADARARAVRGGRTRTATAKLSADTVETVDGLRELLAF
                     GALAQRRRKLAERGRQVGAAQRSEATWEAVTAAVRDLLIVAAVLGVVAAAAHSVTSGRL
                     HGAWAPAAMALALSVLGPVAESARALSQAVALRAAAARVDAAVKAPALAPPPTAPRPLP
                     PGPLGVRLRGVSFDYGGTPVLDGVELTVPPGQTLALVGTSGAGKSTCAHLLARFWDPAA
                     GAVQLLPAGCDPVDMREVSDAELRRAVTLVGQDTPLFHGTLAENLRLAAPEADDRALAE
                     AARRCGVDRIAPMDTLVGERGATLSGGQRARIALARALLVRPRVLVLDESTAHLDNAGD
                     AQLATALEEESRTTIVIAHRPATIRRAGRIAVLEEGRIVEEGTWEELTGHPDSALNRVL
                     TTTS"
     gene            complement(2102..3841)
                     /locus_tag="A4E84_RS01295"
                     /old_locus_tag="A4E84_01295"
     CDS             complement(2102..3841)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004120.1"
                     /locus_tag="A4E84_RS01295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01295"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_062924763.1"
                     /transl_table=11
                     /translation="MIVHPELRRAARPARRPLLAATLLQGAVTLTHLAQAALLALALAG
                     LAHRDTGRLPWLLAAVLAVVGARAGLTVWQRRTATRAGARVRVALRDELLAHLGRLGPA
                     HLTTARAGAVRTTLVDGVEGVDTYVSRYLPQLLITLTVPPLVLAALAATEPRALLGLVP
                     ALLLALAGPRAWDRLLAARGKEHWDTYEGLGADYLEALQGMPALRAAGAVGRTRARLEE
                     RSAALHRATVAKLRVSLVDTGITDLAIQGGTAAAALLACWSAVTGSTTATGTYLVLLLA
                     SECFRPVRDLAREWHAGYLGASAADGLAALRTAEPAVEDTGTASAHRQAPPELRFHNVR
                     FTYGDAPAPALDGVSFTAQAGRTTAIVGPSGAGKSTLLALLLRHHDPQEGRITLDGRAT
                     TEYTLASLRQGIAVVSQDTYLFHATIADNLRLARPGATDDDLTRVARAAGIHDEITALP
                     DGYATLLGERGATLSGGQRQRLALARALLADAPVLVLDEATSSVDERREADIVRALPTA
                     ASGRTVLVIAHRLAAVRHADRIVVLDSGRVDAVGEHAGLVEAGGVYTRLVEAGRAHRGE
                     LAA"
     gene            complement(3838..4989)
                     /locus_tag="A4E84_RS01300"
                     /old_locus_tag="A4E84_01300"
     CDS             complement(3838..4989)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048308.1"
                     /locus_tag="A4E84_RS01300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01300"
                     /product="hypothetical protein"
                     /protein_id="WP_062931220.1"
                     /transl_table=11
                     /translation="MEPAREDRPPDLVAALARARSPERPGPDTPAGGAVRAWPGPPTAF
                     PKAGPEDVDVQVLLRLSLAASDGSGRLRPAPSAGALHPVDTELAVGAGCSLPPGRYGYD
                     PLRHRVHRLGGQPDGTPPGVTARLSVTARRTVSHYGHRARPLLLLDTGHAAAALYLAAR
                     ALGVSEPDVRLDGLAESPLAVVHIPPPDRRGPVHPAGSARVPAPSEGRPAPAELLARRS
                     APPPLPGAPSPAALSAVLTTAARAGAGDLRWCAAVGPPQPGLVKPAAGGATLRRYAAGE
                     ARPTLAAWAAGQAWIADAGAVVLAVGCPDHADAPHIRRAHLRAGFAVHLAHVTARRHGL
                     AARPVGSWQQADLGAALGAAPGRDWVVHALALGTRHADEENIT"
     gene            complement(5001..6380)
                     /locus_tag="A4E84_RS01305"
                     /old_locus_tag="A4E84_01305"
     CDS             complement(5001..6380)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409979.1"
                     /locus_tag="A4E84_RS01305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01305"
                     /product="YcaO-like family protein"
                     /protein_id="WP_062924764.1"
                     /sec_met_domain="YcaO (E-value: 3.8e-47, bitscore: 160.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALPLEALVDPVCGIVRKVKPVEHPPGTPPRYTALTAEISDARR
                     LGLWPADRVSLGTTFGDPEQARTAAIAEGIERYCGNRVPPPGHPDAPLRATAAELADKG
                     LRLYGPGDLPAYAPWQYTRAKFPYRPLTADTPALWTRGTEPLADGTTAEVWAPVSLTHL
                     NWRQGDLRELPRTHHLNYAGIATGQGLDDAVERGLLEIVERDALELWWHLDGPARGIDP
                     ASVPGLADDLAGCALDVHIVEMHSEFAPCMAALVHDPRLGLYAAGFACKYDPAEAARKA
                     VLEAVHTWVFTQGLTDPDGWVFQAVEAGLLARGLYLEHRADGRYLDACGEQFEHVRDLG
                     AHVQVWLDERMAAEAGRFTEPARGTVSVDAVEPGSRERLEHALREGGHRVMTFDLTTED
                     VAETTLRVARVLVSGLLPNAPAAFGYFGCPRLSEAAVARGWRTDPPSAPQDFTLAPPPH
                     M"
     gene            complement(6377..7858)
                     /locus_tag="A4E84_RS01310"
                     /old_locus_tag="A4E84_01310"
     CDS             complement(6377..7858)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947325.1"
                     /locus_tag="A4E84_RS01310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01310"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_062924765.1"
                     /transl_table=11
                     /translation="MTAFSTAVDGLATDVQLPAGDGPFPAVLIRTPYDRARHRAEACGW
                     ARRGFAAVVQDVRGRFASSGEWHPYTNEAADGAATVRWIRKQTWGDGRLVAVGASYAAH
                     CALVLALDAPRDARPDAVIAAVPALGLAETAREASGVERLRPRAGWWAAHGDRRDSDES
                     ALDEALAMDPGLFTHLPLTALPERLGRSLPSWADLWRHHDRGRLVTRAAHAGLPLLAVG
                     GHHDHFTDDTVALWRTWGGPSARLLLGPWGHALRSAPGPDAGPAHRLNLGELYVRWACR
                     ALSGELAPGRHGALALGGADLWLPAGADGEPRTQRPRLLHGPAFTADPDRPVRSDDLTV
                     PTDGPPDRCVLVTPPLPRPLDVAGPVGARLRATAYTPSADWAARLVALTPGGDAERLAV
                     GVVRRAGPVGRAAEFTIGLGRLTRRLRAGTRLRLEIAGHHFPAHARNPHTGGDPVTAHR
                     LLASRREVDPAAVALTLHVLPSRPTPTDPAEEILR"
     gene            complement(7855..8703)
                     /locus_tag="A4E84_RS01315"
                     /old_locus_tag="A4E84_01315"
     CDS             complement(7855..8703)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048303.1"
                     /locus_tag="A4E84_RS01315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01315"
                     /product="hypothetical protein"
                     /protein_id="WP_062924766.1"
                     /transl_table=11
                     /translation="MSNSRLVPGAEVVAVPGRGLAVRTPEGDFLTVRTGDADERLLLSR
                     LTGDETTTRADTELDRVIRGFEQAGFLADGTPHAEWPADRRHIRLIGDPVLTGPLAEHL
                     TALGADPRTAPAGTTSPAGVDDLLATAPAAVVWCLDGPVPDGLWDAADRLPEHGVAWLR
                     CHREGWQAYVEPVAADPGDVTSAHIRSRRLAATPAYRELAAYWTGPRTLGAPVRLAVPA
                     ATLLAALLADDLTRWATGAPGTAGLPARRRLRRVDLRTLTVTEHPVLPVPDVAAMPKQD
                     G"
     gene            complement(8794..8907)
                     /gene="amiA"
                     /locus_tag="A4E84_RS45130"
     CDS             complement(8794..8907)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048301.1"
                     /locus_tag="A4E84_RS45130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_241270818.1"
                     /transl_table=11
                     /translation="MDNEQVFAPIADPGQLAHDSASHSNALVENPFEDTEE"
     misc_feature    complement(8963..8978)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.11"
                     /tool="antismash"
     gene            complement(8964..9785)
                     /locus_tag="A4E84_RS01320"
                     /old_locus_tag="A4E84_01320"
     CDS             complement(8964..9785)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004114.1"
                     /locus_tag="A4E84_RS01320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01320"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_062924767.1"
                     /transl_table=11
                     /translation="MTESVGIHVEGVHFGYPGRPVLRGVDMTVRPGELTALIGLNGCGK
                     STLLRLAAGLLRPDAGRVLLGADDLARLSRRATARRVALLHQSAPAVPGMTVRHLVRQG
                     RYAARGPLGMLREGDDPVVERALRDVGVEQWADRDVDALSGGERQRVRLAMALAQDTRV
                     LLLDEPTTYLDLHHQLDVLQTVVRLREERGLTVVMVLHDLAHAARFAERIVALREGRVV
                     ADGTPKQVVTPGLLAEVLKVAGRVGEDPEGGWPVCYPDHPIAALEYENQIH"
     gene            complement(9805..10776)
                     /locus_tag="A4E84_RS01325"
                     /old_locus_tag="A4E84_01325"
     CDS             complement(9805..10776)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328328.1"
                     /locus_tag="A4E84_RS01325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4E84_01325"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_237305107.1"
                     /transl_table=11
                     /translation="MCAGVELVAGRGMSPGVVWDVVNGGGDATARHIFFQLRLPRLLVS
                     LGAGACLAVAGLVLQSALRNPLAGPEVTGVTPGAVLGAVTATALGLAGWDSPLAVVLAA
                     CTGGCAGAALLWLLAGRGRGDPAQTAVHGVLVSAVLGGLTAMVLLVEPGELGSVVQWLV
                     GTTEGRVWQHWHLLWPWALVWGAGAWLLAGPLTLLRCGDDIALTAGLSVRPARTLALLC
                     AVALTAGAVAAVGALGFVGLLVPHLAVAVFGADLRVSLPGAALVGAVVVCGADAAAQLS
                     SRLPAPPGLDSGRFTLPVGALTACLGAALLLVVVRRTPSRTF"
ORIGIN
        1 cgccgccctg gtcgcggacg gcgtggcggt ggggctgacg accgtctacc gcacgctgcg
       61 attactggag acggccgggc acgtagacgt ggtgcgcgac agcgacggtg agcggctcta
      121 ccggcccaga cccgacgagg gtcaccgcca ctacctggtc tgccgggagt gcgggctcag
      181 cctcgccgtc gacgccgagg aggtcgagcg gtgggtgacc aggaccgcgc gtgacatcgg
      241 cttccacgcg gtgacccaca cggtcgagct cacgggcgtg tgcggcggct gcctgtccgg
      301 gccggaccgc cggccggctc ccgacacgta gcagaccccg gatgtcacag ccgggcccgt
      361 gctcatgacg tggtggtcag aacgcggttg agcgcgctgt cggggtggcc ggtgagttcc
      421 tcccaggtgc cctcctccac gatgcggccc tcctccagga cggcgatgcg gccggcgcgg
      481 cggatggtgg ccgggcggtg ggcgatgacg atcgtcgtac ggctctcctc ctccagagcg
      541 gtggcgagtt gggcgtcgcc cgcgttgtcc aggtgagcgg tggactcgtc gagtacgagg
      601 acgcgcggcc ggaccagcag cgcgcgggcg agcgcgatac gggcccgctg gccgccggag
      661 agcgtggcgc cgcgctcgcc gacgagcgtg tccatcgggg cgatccggtc gacaccgcag
      721 cgccgtgccg cctcggccag cgccctgtcg tccgcctcgg gagcggccag ccgcaggttc
      781 tcggcgagtg tgccgtggaa gaggggcgtg tcctgtccca ccagcgtcac cgcacgccgc
      841 agttccgcat cgctcacctc ccgcatgtcc acgggatcgc agccggcggg cagcagctgg
      901 accgcgccgg ctgccgggtc ccagaagcgg gccagcaggt gggcgcaggt cgacttgccg
      961 gcacccgagg tgccgaccag cgcgagtgtc tgcccgggcg ggacggtcag ttccacgccg
     1021 tccagcacgg gtgtgccgcc gtagtcgaag ctcaccccgc gcagccggac gcccagcggc
     1081 ccgggcggca gggggcgcgg tgcggtgggc ggcggggcca gggcgggggc cttgacggcc
     1141 gcgtcgacgc gcgcggcggc ggcgcgcagt gccacggcct ggctcagggc gcgggccgat
     1201 tccgcgacgg gaccgaggac ggacagggcc agcgccatcg ccgccggagc ccaggcgccg
     1261 tgcagtcgtc cggaggtcac ggagtgcgcc gccgcggcca ccacgccgag tacggcggcc
     1321 acgatgagga ggtcgcggac cgcggcggtg acggcctccc aggtggcctc ggagcgctgg
     1381 gccgcaccca cctgccggcc ccgctccgcc agcttgcgac ggcgttgcgc cagggcgccg
     1441 aaggcgagca gttcgcgcag cccgtcgacg gtctccaccg tgtcggccga cagtttcgcc
     1501 gtggccgtcc gggtgcggcc gccgcgcacc gcgcgtgccc gcgcgtcggc gaagggcgcc
     1561 gccgcgagca ggaccgcgac cggcatcacg gccgccagca gccacggctc caccagggcg
     1621 agaacggcgg agccgccggt gaagaccgtg ccggccgcca gaagttgggc ggtggtgtgt
     1681 gcgtagaaga actccagggc ctccacgtcg gccatggcgg tggcggcgag gtcgccgctg
     1741 cgccgtcccg ccacccgggc gggcgcgctg cgggccagtc cgtcgaagac gcgtacccgc
     1801 agtgcggcca gcacccggta ggcgaggtcg tgcgagaggt ccatctcccg ccaggtcatc
     1861 agggcgcgca gggcgacgag gacgacgagc gcggtgacgg tgccggccgc gggtgcccgc
     1921 tcgtcgatga cggcggctcc cacggtgtgg gcggccaggg tcagcagcgc gacgagggag
     1981 ccctgttcga ggagggcggc ggcgcaggtg cgggctgtca tggcccggtg ctccgccagg
     2041 gcgggcagca gggcgcgcag cgcgcctcgg gcgggtgcgt ccgcgtcggc ggcgacggtg
     2101 ctcatgcggc gagttctcct cggtgggcgc ggccggcctc gacgagccgg gtgtagacgc
     2161 cgccggcctc gacgagaccg gcgtgttcgc cgacggcgtc cacccgtccc gagtcgagga
     2221 cgacgatgcg gtcggcgtgg cggacggccg cgagccggtg ggcgatcacc aggaccgtcc
     2281 ggccgctcgc ggcggtcggc aacgcccgga cgatgtcggc ctcgcggcgc tcgtcgaccg
     2341 agctggtggc ctcgtcgagg acgagcaccg gggcgtcggc cagcagggcc cgcgcgagcg
     2401 cgaggcgctg ccgctggccg ccggagaggg tggctccccg ttcgccgagg agggtggcgt
     2461 agccgtcggg aagggcggtg atctcgtcgt ggatcccggc ggcgcgcgcc accctggtca
     2521 ggtcgtcgtc cgtggcgccg ggccgggcca ggcgcaggtt gtcggcgatg gtggcgtgga
     2581 acaggtaggt gtcctgcgag acgacggcga tgccctgcct cagcgaggcg agcgtgtact
     2641 cggtcgtggc gcgtccgtcg agggtgatcc ggccttcctg tgggtcgtgg tggcgcagga
     2701 gcagggcgag gagtgtggat ttgcccgcgc cggaggggcc gacgatcgcg gtcgtccggc
     2761 ccgcctgcgc ggtgaacgag acgccgtcca gggccggggc cggcgcgtcg ccgtaggtga
     2821 accggacgtt gtggaagcgc agttcgggtg gagcttgccg gtgcgcggag gccgtgccgg
     2881 tgtcctcgac cgccggctcg gccgtgcgca gggccgcgag gccgtcggcg gccgacgccc
     2941 ccaggtatcc ggcgtgccat tcgcgggcga ggtcgcgcac ggggcggaag cactccgagg
     3001 ccagcagcag caccagatac gtgccggtcg cggtggtgga tccggtgacg gccgaccagc
     3061 acgccaggag ggccgcggcg gcggtgccgc cctggatggc gaggtcggtg atgccggtgt
     3121 cgaccaggga cacccgtagt ttggcgacgg ttgcgcggtg cagcgccgcg gaccgctcct
     3181 ccaggcgtgc gcgggtgcgt ccgacggcgc ctgcggcgcg cagggcgggc atgccctgga
     3241 gggcctccag gtagtcggcg cccagtcctt cgtacgtgtc ccagtgctct ttgccgcggg
     3301 cggcgaggag ccggtcccag gcgcgtggcc cggccagggc caggagcagg gcggggacga
     3361 ggccgaggag ggcccggggt tcggtggcgg ccagggcggc gaggaccagg ggcggcaccg
     3421 tgagggtgat aaggagctgt ggcaggtacc gggagacgta ggtgtcgacg ccctcgaccc
     3481 cgtcgacaag ggtggtgcgg acggctccgg cccgtgcggt ggtcaggtgt gcgggcccca
     3541 accggcccag gtgtgcgagg agttcgtccc gcagggctac ccggacccgg gccccggcac
     3601 gggtggcggt acgccgctgc cacaccgtga gcccggcacg ggcgcccacg acggcgagca
     3661 cggcggccag cagccacggg agccggccgg tgtcgcggtg tgccaggccg gctagagcga
     3721 gggccagcag ggcggcctgc gccaggtggg tgagggtgac ggcgccctgc aggagggtgg
     3781 ccgcgagcag ggggcgccgt gcgggacggg cggcgcggcg cagctcggga tggacgatca
     3841 cgtgatgttc tcctcgtcgg cgtggcgggt gccgagggcc agtgcgtgga cgacccagtc
     3901 ccggcccggg gcggcgccga gcgcggcgcc gaggtccgcc tgctgccagg acccgacggg
     3961 ccgggcggcc agtccgtggc gccgggcggt gacatgggcc aggtggacgg cgaagccggc
     4021 ccgcaggtgg gcgcggcgga tgtgcggtgc gtcggcgtgg tcgggacagc cgacggcgag
     4081 cacgacggcg cccgcgtccg cgatccaggc ctggcccgcg gcccaggcgg cgagcgtagg
     4141 gcgcgcctct cccgccgcgt accgccgcag ggtcgcgccg ccggcggccg gcttcaccag
     4201 cccgggctgt ggcgggccta cggcggcgca ccagcgcagg tcgccggcgc ctgcccgcgc
     4261 ggcggtggtg aggaccgccg acagtgcggc cggggaggga gcgccgggca ggggcggtgg
     4321 ggcgctgcga cgcgccagca gctccgcggg cgccggccgg ccctccgacg gcgccggaac
     4381 gcgagcgctg ccggccgggt gcaccgggcc gcgccggtcg ggcgggggga tgtgcacaac
     4441 ggccagtggg ctttcggcga gtccgtccag ccgtacgtcg ggctcgctca ctccgagtgc
     4501 gcgggccgcg aggtacagcg cggcggcggc gtgcccggtg tcgaggagca gcaggggccg
     4561 ggcccggtgg ccgtagtggg agaccgtgcg ccgtgcggtg accgagagtc gggccgtcac
     4621 gcccggcggc gtgccgtcgg gttgcccgcc gaggcggtgc acgcggtggc gcagcgggtc
     4681 gtagccgtag cgtccgggcg gcagagagca gccggcgccg acggccagtt cggtgtcgac
     4741 cgggtgcagg gcaccggcgg aaggggcggg ccgcagtcgg ccggagccgt ccgaggccgc
     4801 cagggagagg cgcagcagga cctgcacgtc gacatcctcc ggcccggcct tcgggaaggc
     4861 ggtcggcggg cccggccagg cgcggacggc tcctccggcg ggtgtgtcgg ggccggggcg
     4921 ctccggggag cgggctcggg cgagggcggc gacgaggtcc ggcgggcggt cctcgcgggc
     4981 gggttccacg ggggcggccc tcacatgtgc ggcggaggcg ccagggtgaa gtcctgcggc
     5041 gcgctcggcg ggtcggtgcg ccatccgcgc gcgacggcgg cctcggacag ccgcgggcag
     5101 ccgaagtagc cgaaggccgc cggggcgttg ggaaggagcc ccgagacgag gaccctggcg
     5161 acgcgcaggg tggtctcggc gacgtcctcg gtggtgaggt cgaaggtcat gacccggtgg
     5221 ccgccctcgc gcagcgcgtg ctccagccgc tcccggctgc cgggttcgac cgcgtcgacg
     5281 gacacggtcc cgcgggccgg ttcggtgaac cgcccggcct cggcggccat ccgctcgtcc
     5341 agccacacct gcacgtgtgc gcccaggtcc cggacgtgct cgaactgctc accgcacgcg
     5401 tcgagatagc ggccgtcggc ccggtgctcc aggtagagcc cgcgagcgag cagcccggcc
     5461 tcgacggcct ggaacaccca gccgtcggga tcggtcaggc cctgggtgaa gacccaggtg
     5521 tggacggctt cgaggacggc cttgcgggcg gcttcggccg gatcgtactt gcaggcgaag
     5581 ccggcggcgt acaggccgag gcgcgggtcg tgcacgagtg cggccatgca gggggcgaac
     5641 tccgagtgca tctcgacgat gtggacgtcg agcgcgcagc cggcgaggtc gtcggcgagg
     5701 ccgggcacgc tggccgggtc gatgccccgg gccgggccgt ccaggtgcca ccacagttcc
     5761 agggcgtccc gttcgacgat ctccagcagg ccgcgttcca cggcgtcgtc gaggccctgg
     5821 ccggtggcga tcccggcgta gttgaggtgg tgggtgcggg gcagctcgcg caggtcgccc
     5881 tggcgccagt tgaggtgggt gagcgagacg ggtgcccaga cctcggcggt ggtcccgtct
     5941 gcgagcggtt ccgttccgcg cgtccacagg gccggggtgt cggcggtgag ggggcggtag
     6001 gggaacttcg cccgggtgta ctgccagggc gcgtaggcgg gcaggtcccc ggggccgtac
     6061 aggcgcaggc ccttgtcggc cagttcggcg gcggtggcgc gcagcggggc gtcggggtgg
     6121 ccgggcggtg gcacgcggtt gccgcagtac cgctcgatgc cctcggctat agcggcggtg
     6181 cgggcttgct cggggtcgcc gaaggtggtg ccgagggaga cccggtcggc cggccacagt
     6241 ccgagtctgc gggcgtcgga tatctcggcc gtgagtgcgg tgtagcgggg tggggtgccc
     6301 ggggggtgct cgacgggttt gaccttgcgg acgatgccgc agacggggtc gacgagtgct
     6361 tccagcggca gcgccgtcat cgcaggatct cctcggcggg gtcggtgggg gtgggacggg
     6421 acgggagcac gtgcagagtg agggccacag cggccggatc gacctcgcgc cgggaggcga
     6481 gcagccggtg ggccgtcacc gggtcgccgc cggtgtgagg gttgcgggcg tgggccggga
     6541 agtggtggcc ggcgatctcc aggcgcagcc gggtgccggc tcgcagccgg cgcgtgagcc
     6601 ggccgaggcc gatggtgaac tcggctgcac ggccgaccgg tccggctcgc cggacgacgc
     6661 cgacggcgag ccgttcggcg tccccgcccg gtgtgagcgc gacgagccgg gcggcccagt
     6721 ccgcggacgg cgtgtaggcg gtggcccgca gtcgcgcgcc gacgggtccg gccacgtcga
     6781 gcggacgggg cagcggcggg gtgaccagca cacagcggtc gggcggtccg tcggtcggga
     6841 cggtcaggtc gtcggagcgg acgggccggt cggggtccgc ggtgaacgcc gggccgtgca
     6901 gcagccgcgg ccgttgtgta cgcggttcac cgtcggcacc ggcgggcagc cacaggtcgg
     6961 ctccgcccag tgccagtgcg ccgtggcggc cgggggcgag ttcaccggac agggcgcggc
     7021 aggcccagcg cacgtacagc tcgccgaggt tcagccggtg ggcgggtccc gcgtccgggc
     7081 ccggcgcgga gcggagggcg tgcccccagg ggccgaggag cagacgcgcc gaggggccgc
     7141 cccaggtgcg ccacagggcg acggtgtcgt cggtgaagtg gtcgtgatgg ccgcccaccg
     7201 cgagcagggg cagcccggcg tgtgcggccc gtgtcacgag gcgcccgcga tcgtggtggc
     7261 gccacagatc cgcccaggag ggcaggctcc ggcccagccg ctcggggaga gcggtcaggg
     7321 gcaggtgggt gaacaggccg gggtccatgg cgagggcctc gtccaaggcg ctctcgtcgg
     7381 agtcccgccg gtcgccgtgg gcggcccacc atccggcgcg cgggcgcagc cgttccacgc
     7441 cggatgcctc gcgcgccgtc tccgcgaggc cgagggcggg cacggccgcg atgacggcgt
     7501 ccggccgcgc gtcccggggt gcgtcgaggg cgaggacgag ggcgcagtgg gcggcgtagg
     7561 aggcgccgac ggccaccagc cggccgtctc cccaggtctg cttccggatc cagcggacgg
     7621 tcgccgctcc gtcggcggcc tcgttcgtgt aggggtgcca ctcccccgac gaggcgaagc
     7681 ggccccgtac gtcctggacg acggcggcga atccacggcg ggcccagccg caggcttcgg
     7741 cccggtgccg ggcacggtcg tagggggtgc ggatcaggac ggccgggaag gggccgtcgc
     7801 ctgcggggag ttgcacgtcg gtggcgagcc cgtcgacggc cgtgctgaac gccgtcatcc
     7861 gtcctgcttc ggcatcgctg cgacgtcggg caccggcagg acggggtgtt ctgtgacggt
     7921 cagggtgcgc aggtcgaccc ggcgcagccg gcgtcgtgcc gggaggccgg ccgtgccggg
     7981 ggctccggtg gcccaccggg tgagatcgtc ggcgagcagc gccgcgagca gtgtggcggc
     8041 ggggacggcg agccggaccg gtgcgccgag ggtgcggggc ccggtccagt acgcggccag
     8101 ttcgcggtaa gcgggggtgg cggcgagccg gcgggagcgg atgtgggccg aggtgacgtc
     8161 tccgggatcg gcggcgaccg gctcgacgta cgcctgccag ccctcgcggt ggcagcgcag
     8221 ccaggcgacg ccgtgctcgg gcagccggtc ggcggcgtcc cacagcccgt cgggcacagg
     8281 tccgtcgagg caccacacga cggcggcggg ggccgtggcg agcaggtcgt cgacgccggc
     8341 cggtgacgtg gtgccggccg gagcggtgcg cgggtcggcg cccagggccg tcaggtgctc
     8401 ggcgaggggt ccggtcagta ccggatcgcc gatgagccgg atgtgccggc ggtcggccgg
     8461 ccactcggcg tgcggggtgc cgtccgccag gaatccggcc tgttcgaacc cgcggatgac
     8521 gcggtcgagt tcggtgtccg cccgggtcgt ggtctcgtcg ccggtgagcc gggagagcag
     8581 gagccgctcg tccgcgtcgc cggtcctgac ggtgaggaag tccccttctg gggtacggac
     8641 ggcgaggcct cgcccgggta cggcgacgac ctcggcaccg ggtacgagtc ggctgttgga
     8701 cacggcgttc ctcctggcga cgggctgggg acgggcgtgg gcccgcccgg aaggcaacgg
     8761 gcgggcccac ggtcgaggga gctgagccct cgcttactcc tcggtgtcct cgaaggggtt
     8821 ctcgacgagc gcgttggagt gggaagccga gtcgtgagcc agctgacccg ggtcggcgat
     8881 cggcgcgaag acctgctcgt tgtccatgaa ctctccttca tctcagggag atacggcgtt
     8941 cggatgagcg ccgtgatcac acgctaatga atctgatttt catattcaag agctgcgatg
     9001 gggtgatctg ggtaacacac cggccaaccc ccttccggat cctcaccgac ccggccggcc
     9061 accttgagga cctccgccag caaccccggt gtgacgacct gcttcggcgt cccgtcggcc
     9121 accacacggc cctcccgcag ggcgacgatc cgctcggcga accgggccgc gtgggccagg
     9181 tcgtgcagca ccatcaccac ggtgagcccg cgctcctcac gcaggcgcac cacggtctgc
     9241 agcacgtcga gttggtggtg caggtccaga taggtggtcg gctcgtcgag cagcaggacc
     9301 cgggtgtcct gggcgagggc catcgcgagc cgcacccgct gccgctcacc ccccgacagc
     9361 gcgtcgacgt cacgatcggc ccactgctcc accccgacat cgcgcagagc ccgctccacg
     9421 acggggtcgt cgccctcacg cagcatgccg agcggtccgc gtgccgcgta ccgcccctga
     9481 cgtacgaggt gtcgcaccgt catacccggt acggccgggg cggactggtg cagcagcgcc
     9541 accctgcgtg ccgtggcgcg cctcgaaagc cgggcgagat cgtcggcacc gagcagtaca
     9601 cgccccgcgt ccggccgcag cagccctgcg gccagccgca gcagggtcga cttgccgcaa
     9661 ccgttcaggc cgatgagggc ggtcagttcg cccggccgga cggtcatgtc gacgcccctc
     9721 agtacgggtc gcccgggata gccgaagtgg accccctcga cgtggatccc cacggactcg
     9781 gtcatgctca tccttcggtc ggcttcagaa cgtacggctc ggcgtgcggc gcacgacgac
     9841 cagcaacagc gcggcgccga ggcaggcggt gagcgccccg accggcagcg tgaaccggcc
     9901 ggagtccagc ccgggcggcg ccggcagacg tgaggacaac tgcgcggcgg catccgcccc
     9961 gcacaccacg accgcgccca ccagggcagc gccgggaagg ctcacccgca ggtccgcgcc
    10021 gaagacggcc acggccagat gcggaacgag cagccccacg aagcccagcg ccccgacggc
    10081 ggccaccgcg cccgccgtca gcgccaccgc gcacagcagg gccagggtcc gcgccggacg
    10141 gacggacagg ccggccgtga gggcgatgtc gtccccgcag cgcagcaggg tcagcggtcc
    10201 ggccagcagc caggccccag cgccccagac gagcgcccag ggccacagca ggtgccagtg
    10261 ctgccacacc cggccctcgg tggtgcccac caaccactgg acgacgctgc cgagttcacc
    10321 cggctccacc aggagcacca tggcggtgag gccgccgagc accgcagaca ccagcacccc
    10381 gtgcacggcg gtctgtgccg ggtcgccacg gccgcggccg gcgagcagcc acagcagcgc
    10441 cgctccggca cacccgcccg tacaagccgc gaggacgacg gccagcggcg agtcccatcc
    10501 ggcgagcccc agagcagtcg cggtgacggc cccgaggacc gcgcccggcg tcacgcccgt
    10561 cacctccggc ccggcgagcg ggttgcgcaa cgccgactgg aggaccagcc ccgccacggc
    10621 caggcacgcg ccggccccga gggacaccag cagcctgggc aggcgcagtt ggaagaagat
    10681 gtggcgtgcc gtcgcgtcac cgccgccgtt cacgacgtcc cagaccacgc ccggggacat
    10741 gccgcgcccg gccaccagtt ccacaccggc gcacatgacg gccagggccg caagcgccgc
    10801 gaaacgccgg gtcaccgcgc gtcctccctt ccggtcggcc gggaaggaga cgggcgggtc
    10861 ccgccggccc cggcttcctc tcggcgagcc tcgtccaagg cgccggcacg agggacttcg
    10921 tccgccgcgc cggatacagc cgtccgtggg ccgcgcagcg ccttgcccac ggcagacgcg
    10981 gaccgggccg cccggccgcg gccgcccgac cgcatcaggg cgaccccggc cggcaccccc
    11041 agcagagccg tccaggcacc ggccggcgtc tccacgggcg ccagcgccag ccgggccggg
    11101 acatcagcga ccgtcacgac ggcggcaccc caggcggcgg accacggaag ccagcgcacc
    11161 gctcccgccg cggggttgaa ccaccgggcc agatgcgggg cgaggaagcc cacccacgcg
    11221 acgggcccgc acaccgccgt caccggggcg atcagcacca cggcgatggc cagcgcggcg
    11281 agccgggccc gctgggcgcg cacgcccagc gcctcggcat cctcatcccc cagccgcatc
    11341 acggacagca ccggcgcgca cagcacgagg gcgggaaccg
//
