GCF_001590785.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_LTAO01000012.1 (Alkalihalobacillus trypoxylicola)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	hserlactone	363,263	383,694
Region 12.2	terpene	723,725	744,576

NZ_LTAO01000013.1 (Alkalihalobacillus trypoxylicola)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	terpene-precursor	1	18,931

NZ_LTAO01000034.1 (Alkalihalobacillus trypoxylicola)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 29.1	T3PKS	1	29,697

NZ_LTAO01000036.1 (Alkalihalobacillus trypoxylicola)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 30.1	lassopeptide	77,581	102,149	Low	paeninodin	ribosomal:unmodified

NZ_LTAO01000037.1 (Alkalihalobacillus trypoxylicola)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 31.1	ectoine	27,415	37,813	Medium	ectoine	other:other
Region 31.2	terpene	62,454	83,329

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	hserlactone	363,263	383,694
Region 12.2	terpene	723,725	744,576
Region 13.1	terpene-precursor	1	18,931
Region 29.1	T3PKS	1	29,697
Region 30.1	lassopeptide	77,581	102,149	Low	paeninodin	ribosomal:unmodified
Region 31.1	ectoine	27,415	37,813	Medium	ectoine	other:other
Region 31.2	terpene	62,454	83,329

No secondary metabolite regions were found in these records:: NZ_LTAO01000001.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000002.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000003.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000004.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000005.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000006.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000007.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000008.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000009.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000010.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000011.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000014.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000015.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000016.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000017.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000018.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000019.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000020.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000021.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000022.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000023.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000024.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000025.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000026.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000027.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000028.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000038.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000039.1 (Alkalihalobacillus trypoxylicola); NZ_LTAO01000040.1 (Alkalihalobacillus trypoxylicola)

Compact view

NZ_LTAO01000012.1 - Region 1 - hserlactone

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Location: 363,263 - 383,694 nt. (total: 20,432 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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core biosynthetic genes

additional biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

AZF04_RS08940: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: phosphorylase

AZF04_RS08925: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

Hydrolases: esterase

AZF04_RS08965: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002694.2	0.45	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0000410.5	0.42	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002073.3	0.40	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0002476.2	0.39	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002682.2	0.38	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.38	other (other)	aerobactin	Grimontia hollisae
BGC0001870.3	0.37	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002685.2	0.36	NRPS	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0002415.2	0.35	NRPS	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002694.2	0.45	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0000410.5	0.42	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002073.3	0.40	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0002476.2	0.39	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002682.2	0.38	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.38	other (other)	aerobactin	Grimontia hollisae
BGC0001870.3	0.37	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002685.2	0.36	NRPS	enterobactin	Rothia mucilaginosa ATCC 25296
BGC0002415.2	0.35	NRPS	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.71 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.11 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.18 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.94 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.17 out of 29.38

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.02 out of 32.93

Confidence: medium

Additional weak hits (6):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.45 out of 23.43

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.93 out of 27.55

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.14 out of 25.88

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.84 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.82 out of 32.93

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.69 out of 29.38

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_LTAO01000012.1 - Region 2 - terpene

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Location: 723,725 - 744,576 nt. (total: 20,852 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene overview

Tailoring

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KnownClusterBlast

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Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.29	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002667.2	0.24	ribosomal	estericin A	Clostridium estertheticum
BGC0001206.5	0.24	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001671.3	0.21	NRPS	monobactam	Agrobacterium tumefaciens
BGC0002496.3	0.19	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000689.3	0.19	saccharide	2-deoxystreptamine	Micromonospora echinospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.29	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002667.2	0.24	ribosomal	estericin A	Clostridium estertheticum
BGC0001206.5	0.24	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001671.3	0.21	NRPS	monobactam	Agrobacterium tumefaciens
BGC0002496.3	0.19	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000689.3	0.19	saccharide	2-deoxystreptamine	Micromonospora echinospora

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

AZF04_RS10600: PT_phytoene_like

Domain 1 (14 - 210): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06

Confidence: strong

Additional weak hits (2):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.21 out of 39.62

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.76 out of 30.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_LTAO01000013.1 - Region 1 - terpene-precursor

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Location: 1 - 18,931 nt. (total: 18,931 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

AZF04_RS10885: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

AZF04_RS10855: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

AZF04_RS10860: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

AZF04_RS10860: PT_FPPS_like

Domain 1 (33 - 293): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

Additional weak hits (6):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.01 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.06 out of 26.85

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.78 out of 18.46

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_LTAO01000034.1 - Region 1 - T3PKS

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Location: 1 - 29,697 nt. (total: 29,697 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene overview

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NRPS/PKS domains

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: formyltransferase methyltransferase

AZF04_RS15480: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

AZF04_RS15535: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Hydrolases: hydrolase

AZF04_RS15525: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: lyase

AZF04_RS15500: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase

AZF04_RS15475: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.49	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0002645.3	0.41	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0001663.3	0.37	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0000879.5	0.37	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001964.2	0.36	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0000937.5	0.36	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0002669.2	0.36	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001566.3	0.35	PKS	Cylindrocyclophane D, Cylindrocyclophane E, Cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.49	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0002645.3	0.41	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0001663.3	0.37	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0000879.5	0.37	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001964.2	0.36	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0000937.5	0.36	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0002669.2	0.36	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001566.3	0.35	PKS	Cylindrocyclophane D, Cylindrocyclophane E, Cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.81 out of 27.55

Confidence: medium

Additional weak hits (6):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.53 out of 29.51

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.83 out of 31.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 24.35 out of 33.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.01 out of 26.12

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.71 out of 27.18

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.48 out of 26.85

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes

NZ_LTAO01000036.1 - Region 1 - lassopeptide

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Location: 77,581 - 102,149 nt. (total: 24,569 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase

AZF04_RS16950: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

AZF04_RS16955: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

AZF04_RS16970: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

AZF04_RS16935: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.68	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0002150.2	0.55	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.55	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002312.2	0.53	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.3	0.51	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0001551.4	0.51	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0001496.3	0.47	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0001639.3	0.47	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000741.3	0.46	saccharide	capsular polysaccharide	Streptococcus agalactiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.68	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0002150.2	0.55	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.55	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002312.2	0.53	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.3	0.51	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0001551.4	0.51	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0001496.3	0.47	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0001639.3	0.47	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000741.3	0.46	saccharide	capsular polysaccharide	Streptococcus agalactiae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.06 out of 18.46

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.58 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

Additional weak hits (3):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.87 out of 39.62

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.84 out of 30.25

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 12 - 92; Score: 91.2

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence

NZ_LTAO01000037.1 - Region 1 - ectoine

Download region GenBank file

Download region SVG

Location: 27,415 - 37,813 nt. (total: 10,399 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

AZF04_RS17740: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

AZF04_RS17720: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Lyases: dehydratase

AZF04_RS17705: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000852.5	0.72	other (other)	ectoine	Sporosarcina pasteurii
BGC0000855.3	0.67	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.67	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0002052.3	0.63	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.63	other (other)	ectoine	Streptomyces anulatus
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.56	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000852.5	0.72	other (other)	ectoine	Sporosarcina pasteurii
BGC0000855.3	0.67	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.67	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0002052.3	0.63	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.63	other (other)	ectoine	Streptomyces anulatus
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.56	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.16 out of 26.06

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_LTAO01000037.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 62,454 - 83,329 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

AZF04_RS17875: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

AZF04_RS17885: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Ligases: synthase

AZF04_RS17870: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.75	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000645.3	0.53	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000630.3	0.48	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000656.5	0.47	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000635.3	0.47	terpene	carotenoid	Paracoccus sp. N81106
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000648.3	0.46	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.46	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001456.3	0.43	terpene	isorenieratene	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.75	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000645.3	0.53	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000630.3	0.48	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000656.5	0.47	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000635.3	0.47	terpene	carotenoid	Paracoccus sp. N81106
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000648.3	0.46	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.46	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001456.3	0.43	terpene	isorenieratene	Streptomyces argillaceus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

AZF04_RS17880: PT_phytoene_like

Domain 1 (9 - 287): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.99 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.93 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.60 out of 18.16

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55

Confidence: medium

Additional weak hits (2):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.41 out of 30.11

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.98 out of 27.55

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor