LOCUS       NZ_CP014504            24353 bp    DNA     circular CON 03-MAR-2024
DEFINITION  Pedobacter cryoconitis strain PAMC 27485 chromosome, complete
            genome.
ACCESSION   NZ_CP014504
VERSION     NZ_CP014504.1
KEYWORDS    GSC:MIGS:2.1; RefSeq.
SOURCE      Pedobacter cryoconitis
  ORGANISM  Pedobacter cryoconitis
            Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
            Sphingobacteriaceae; Pedobacter.
REFERENCE   1  (bases 1 to 5950539)
  AUTHORS   Lee,J. and Kim,O.-S.
  TITLE     Complete genome sequence of Pedobacter cryoconitis PAMC 27485
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5950539)
  AUTHORS   Lee,J. and Kim,O.-S.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2016) Division of Life Sciences, Korea Polar
            Research Institute, 26, Songdomirae-ro, Yeonsu-gu, Incheon 21990,
            South Korea
COMMENT     ##MIGS-Data-START##
            alt_elev                          :: 1 m
            assembly                          :: SMRT Analysis v2.3.0
            collection_date                   :: 2014.01.03
            country                           :: Antarctica
            depth                             :: 5-10 cm
            environment                       :: soil
            investigation_type                :: bacteria_archaea
            isol_growth_condt :: 0.1x Tryptic soy agar, celsius degree 20
            lat_lon                           :: 62.236389 S 58.71772199999998 W
            project_name :: Genome sequencing of Pedobacter cryoconitis PAMC
            27485
            sequencing_meth                   :: PacBio RS II sequencing
            geo_loc_name                      :: King George Island
            env_biome                         :: ENVO:01000186
            env_feature                       :: ENVO:00000097
            env_material                      :: ENVO:00001998
            ploidy                            :: haploid
            num_replicons                     :: 1
            ref_biomaterial                   :: not applicable
            source_mat_id                     :: PAMC 27485
            biotic_relationship               :: free living
            trophic_level                     :: chemoheterotroph
            rel_to_oxygen                     :: aerobic
            assembly_name                     :: ASM118778v1
            finishing_strategy :: complete; 110x coverage; 1 contig
            annot_source                      :: prodigal v2.6.1
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 110x
            Sequencing Technology :: PacBio RS II with P6-C4 chemistry
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 09:48:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,049
            CDSs (total)                      :: 4,958
            Genes (coding)                    :: 4,943
            CDSs (with protein)               :: 4,943
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 15
            CDSs (without protein)            :: 15
            Pseudo Genes (ambiguous residues) :: 0 of 15
            Pseudo Genes (frameshifted)       :: 3 of 15
            Pseudo Genes (incomplete)         :: 14 of 15
            Pseudo Genes (internal stop)      :: 2 of 15
            Pseudo Genes (multiple problems)  :: 3 of 15
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:50:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5148518
            Orig. end                         :: 5172871
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014504.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24353
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="18"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24353
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14353](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14353)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(622..1752)
                     /locus_tag="AY601_RS21840"
                     /old_locus_tag="AY601_4416"
     CDS             complement(622..1752)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024831.4"
                     /locus_tag="AY601_RS21840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4416"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_068405100.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.6e-32,
                     bitscore: 110.0, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKKILFLTLETFGGTGGIQKMNRTMSYTLSQLGKKNHWDVTVYA
                     LHDEQSDLLPNYLPMANFKAFKKSKLNYLWHSLKAGMNSDLIILSHVHLSSIGCLIRLL
                     NPACKIWLITHGVEVWRPLKFWKKAIWGIADQIICVSNFTKRKIVEMHPVDPDRCVVLN
                     HALDPFTKLPDFFVKPAHLLKRYDLLAHDKVILSLSRITSTEKFKGYEQTIKAVSRIKE
                     SFPKVKYILAGPYDENEKTRILQLIKDEQLESNFILTGYLEETALADYFLMADLFVMPS
                     KKEGFGIVFIEAMAFGLPVICGNADGSVDAIRNKEMGTAIDPDDSALLEQTIRQKLAHP
                     LTIAERKSIQQQCLKYFNPQDYSNALEKLIKNGATA"
     gene            complement(1865..2383)
                     /locus_tag="AY601_RS21845"
                     /old_locus_tag="AY601_4417"
     CDS             complement(1865..2383)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008240483.1"
                     /locus_tag="AY601_RS21845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4417"
                     /product="UpxY family transcription antiterminator"
                     /protein_id="WP_068405102.1"
                     /transl_table=11
                     /translation="MADIRDKERKQWYPVYTHSRSEKKAYQELLNKDIEAYLPLRRQMK
                     QWSDRKKWVEEPLIKSYVFVHIHQHQQTEVLMTSGVARFLYFSGKIASMPDRQIEELKL
                     VLASAYEFEITEDELLPGEKIIIKAGSLKGMHGEIIKYHSQKQLLLRLGDIKYNIIVHV
                     PASLIERLQ"
     gene            complement(2393..4795)
                     /locus_tag="AY601_RS21850"
                     /old_locus_tag="AY601_4418"
     CDS             complement(2393..4795)
                     /GO_process="GO:0045226 - extracellular polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008240482.1"
                     /locus_tag="AY601_RS21850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4418"
                     /product="polysaccharide biosynthesis tyrosine autokinase"
                     /protein_id="WP_068405104.1"
                     /transl_table=11
                     /translation="MQEVKTAQTYLNSKEVDYLKIIKILFNSWYLIAGPIIIGLITANL
                     YLWYTPKTYSTNGLLKFEEKKPELSDIIGTMGNSDRNTVNLQSESFTIQSRSLLLKAIK
                     NLDYRTSFYLSGRVRTYDMYPKKPLQINLLKFDSLNFYQDLIAFKPINKNKFELSWKIG
                     NNKVQQNFKYGYPVNIGAVTFTIGYPGSVNPNISYLFKFNIPESFLDRVRSGLRINEAI
                     KNSDLLTLQQTDANPQFAMDIINAIMKEYLNFDRNQKTQSATQLIDFITDQLKYLSTEL
                     KGSERSLEKYKENTKIMDVSSSAGIAFSKVSDLESQRSLLKMQLIVIDQLKEQIAAEKN
                     AVNLNLNLEGSIDPLLGVLVGNFNTLINDKNALLKVYHSTSQPVEEINRQISQVKKSAM
                     RNISASNQRIQKSIGYLNDQLAKVNQQVALLPTAEKDLIGLNRNFEINEKVYSFLSEKS
                     LEAQVNRAAILPGAIIVEKAQLNTVPIAPNTDEIYRTAVILGFLAGIGIIIVIRISNPY
                     IYDREIIERTTSIPILGALRKFPEKIDENNSQILSLSKPRSIFAESVRIIRTNLNFLAS
                     GKKSKVICITSESAGEGKSFVIINLASSFALINKKILLIGADLRRPKLHKTFGKPNAMG
                     LSNYLVNKCGIDDIIQESNTKNLDFISSGPIPPNPSELLHLERMAELIGQLRERYDVIL
                     IDTAPVGLVSDSVPLISMSDINLFVIRYGKSKYSSATLPDRLSKEYNLNNLVIVLNAFE
                     KNLLHAGLYKYSGSFSSDTQYDYENSGYYLDEEEKLKWWNIKHWFKS"
     gene            complement(4795..5571)
                     /locus_tag="AY601_RS21855"
                     /old_locus_tag="AY601_4419"
     CDS             complement(4795..5571)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /GO_function="GO:0015159 - polysaccharide transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs) SMCOG1186:
                     polysaccharide export protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF014606.4"
                     /locus_tag="AY601_RS21855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4419"
                     /product="polysaccharide biosynthesis/export family
                     protein"
                     /protein_id="WP_068405106.1"
                     /sec_met_domain="Poly_export (E-value: 1e-14, bitscore:
                     52.5, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSNKYILYAFIFILLTSCFSCSVKQQQALFENRRQAFNNTPTIT
                     DTSAYKIQPQDLLQIKNLQSPKYIVDEPTTTISAAKGANSTDGQTFLVESDGTVALPII
                     GRVKVEGLNRYDAAKKIENIYSKEIKNPIIDLKIVNLKVTILGEVKTQGSYTLVKDRTS
                     LIEMIGEAGGLTERANSKNVRIIRGGIKNQEVIDLDLSNLTTLSDPRIILKNEDIIYVT
                     QNKQAVRTTKVTGFSSILQPIILLLNTALIIYTITR"
     misc_feature    5628..5643
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.37"
                     /tool="antismash"
     gene            5974..6720
                     /locus_tag="AY601_RS21860"
                     /old_locus_tag="AY601_4420"
     CDS             5974..6720
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015809689.1"
                     /locus_tag="AY601_RS21860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4420"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_068405108.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-30,
                     bitscore: 104.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHQPKISLITVTYNAVETLQRCIESVTNQTYGNLEYIIIDGSSTD
                     GTLKIIQNNQKYIHVFNSEHDNGIYDAMNKGINLATGDIIGTLNADDYFANNDVLEKIA
                     QAFNTDHREMLYANLNYVNKHGTVVRKWRSGKYKATKFNWGWMPPHPTFYVKKDFFDKY
                     GLYDLSYGTAADYELMLRFMYLKAVNVFFLDEVIVNMTIGGVSNRNFRNRISAWAGDFK
                     AMKSCQLPIPLLGVIFKPIRKILQFI"
     gene            6737..7855
                     /locus_tag="AY601_RS21865"
                     /old_locus_tag="AY601_4421"
     CDS             6737..7855
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015809710.1"
                     /locus_tag="AY601_RS21865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4421"
                     /product="MraY family glycosyltransferase"
                     /protein_id="WP_084359387.1"
                     /sec_met_domain="Glycos_transf_4 (E-value: 1.3e-36,
                     bitscore: 124.2, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METFDLPIYLNNHPLICCILVFVSSILITLAIIPSIIFVAKTHNL
                     YDNFSYFRKQHLGAIPRLGGVGIYTGFTVTLLFFDLTDKITPINYLLASCMILSIMGIK
                     DDLLGVNPRTKLIIQLITSLILVIPGNTRISSLHGVFGLYDISYPASVVLSLLTIIFII
                     NSFNLIDGIDGLSAMTGIIVNSVFSALFIYMGKYELAAISLAMTGAIIGFIQFNITPAK
                     IFMGDTGALIIGLISAVMAIKFLELNKFTPDHNPDVFPAPAIALAILIIPVSDSLRVFI
                     LRILKGKSPFLADRNHIHHRILKLGFTHMQTTTLLIGVNLLMILIACLFASYGNGFLLI
                     VISLIALMLNWILSYLIRSKERESYALRNLFL"
     gene            8021..8662
                     /locus_tag="AY601_RS21870"
                     /old_locus_tag="AY601_4422"
     CDS             8021..8662
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="AY601_RS21870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4422"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_198163565.1"
                     /transl_table=11
                     /translation="MNKTEPKNRKLTERKLIDAVGEIIRSTGYTGLGVNAIAKSAGVSK
                     KLIYRYFGTVDALIETYLIERDYWVTFSKKVSDAAVASNKKQTMIEFSSSIFENQFDFF
                     FNEDEMQRIILWEISEKSNILNELSRKREAMGEELLKLTDPYFKDSDINFRAVSAIIIC
                     GIYYSVLHTKKNASTLCGLDLNTEAGRKEITKAVRKIVELCFGSKKKKAN"
     gene            complement(9582..9830)
                     /locus_tag="AY601_RS21875"
                     /old_locus_tag="AY601_4423"
     CDS             complement(9582..9830)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS21875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_4423"
                     /product="hypothetical protein"
                     /protein_id="WP_068405112.1"
                     /transl_table=11
                     /translation="MKKQKIEKQLIFDKQIIGDLSAIKGGSAPVTMDVSTYQCQTAGAK
                     CGTADPLPNPNTCSCGTPGDYNDTLRSCGTLPGIRVC"
     gene            complement(10001..10876)
                     /locus_tag="AY601_RS21880"
                     /old_locus_tag="AY601_4424"
     CDS             complement(10001..10876)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="AY601_RS21880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4424"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_068405114.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.6e-45, bitscore:
                     152.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNQVSRKYIVGSEWLCYKIYLSESTADNLLANSIYKTLKKLIKD
                     NEIDSFFFIRYNDPEFHIRLRIKLKNVEKLGFIISVFHNLFNKYVLDERINSIQIDTYQ
                     REIERYGDFTMELSEQFFFYDSLNVLQILSSIDLSTNSDSRWLHAALLINHYLDLFDFD
                     LYERIDFLKNLKSNFNNEYYISSKDSKEIANRYKNKRKLLADLLNSDDAHYNKLFTLHQ
                     RDSSSQSFVIKSLISNFAHNSPFIPANRLITSFFHMSLNRIFIKDNSVSEYILYDFMHR
                     YFLEESYKEK"
     gene            complement(10869..13085)
                     /locus_tag="AY601_RS21885"
                     /old_locus_tag="AY601_4425"
     CDS             complement(10869..13085)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="AY601_RS21885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4425"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_068405117.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.4e-104,
                     bitscore: 347.9, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNPYHYFDKYFLRFPVYSIDGIKEIIHEDNMFNFFCLNKYFQMA
                     ILISSPDLYLQLKAIEIKNHVEINTKDKVRFNSTLMKYLSRMSTRSTPFGLFSGISVGE
                     LGKESKIVIDSSKITLNYQYDNTFLYELVTALYRLEPDKFSDMNIYSNNMLFGHDKRYK
                     FIEFFDNFPKGERTFKEVITSNNTYLTRILKLTKTGCTLGILLDDLISQGYSKSDALAY
                     LDTLIINKLLLTEIQPTLREDYFTKIVSLSNKLIDNILLRDIVNKYTQILKDINSDGLD
                     IQKFNEIIDIKKNSVDGLINFSPIKSTVVMKDGINTLDKTTFLKIKSLLPFFNKITTAI
                     NNPELEQFTQSFYKKYEFREVNIVTLMDNDIGLGYPINHHQISSNPLIENLNIKQKQRK
                     SDIIRWNTVTSILHERILSAYTHNKTVIELYDSDFEDLKENWDDIPNTIYANIKILQTS
                     DGKKIVINGFGGPSAVNLLTRFTYQDKTTKYLVSDIVKKENENADRKGYINAEIIHAPN
                     IHLTNVFEQKHIFDHFIPILSAPLSTVANPIPIEDIMVRLTNDMKIELRSKKLNKIIKP
                     FLPNAHNSLKSNIPVYRFLTDLQLYGKRNYLGFYLDDLQKMFSHIPRIEYKNCIVLEAR
                     WFIKFNEPTLKGINQEDTNALVNSINNFRNKFKLPELVLLCEGDNELLIDFENQLSVKI
                     FLNKLLKSNTILLKEFLFKEESLVKNVTNQNHCHELIISFYKNA"
     gene            complement(13148..14353)
                     /locus_tag="AY601_RS21890"
                     /old_locus_tag="AY601_4426"
     CDS             complement(13148..14353)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="AY601_RS21890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4426"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_068405120.1"
                     /sec_met_domain="LANC_like (E-value: 7.1e-52, bitscore:
                     174.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYELAKEKLKQIAKELKDEKYLNSPNLGVLNGISGIALFLFHYY
                     KYSGDEYYSDLGKKYIVEIIDRINNGYSFPTYCSGIAGAAWTIEYLNEYNFIQFSSDEN
                     FNEIDEFLAENMNSCMKKGQFDFLHCSIGYGYYFLKRYNLTNSKRLKQKYLNYIHDLID
                     GLSAFSFKSQNGIYWINTFEGFPKNSVDTGFAHGMSGIISFLTNVLSYNIKSPKALKML
                     DLATNFLLTARNDQLDSAYPKNIYINLIDPHLAEASRMAWCYGDLGIASAFMNASRFIK
                     GQDLLKESERIMIKCCSRRSLLETGVVDSGLCHGSLGIAVIYKSFYDITSNKNFSQASN
                     YWLNDGLMKGSFPDGLGGFKKYDYNKYINEVNLLDGIAGIGLGIISLISDTELNWKQSM
                     MI"
     gene            complement(14574..14918)
                     /locus_tag="AY601_RS21895"
                     /old_locus_tag="AY601_4427"
     CDS             complement(14574..14918)
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015925.4"
                     /locus_tag="AY601_RS21895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4427"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="WP_068405121.1"
                     /transl_table=11
                     /translation="MIAVIFEVIPATGKMADYLSIAAKLNPELSTIPGFISIERFQSLV
                     HPDKILSLSFWENEKAILEWRNIEMHRDAQAQGRETVFNDYHLRIATVVRDYGMFDRKE
                     APADSKIAHG"
     gene            complement(14915..16045)
                     /locus_tag="AY601_RS21900"
                     /old_locus_tag="AY601_4428"
     CDS             complement(14915..16045)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="AY601_RS21900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4428"
                     /product="cytochrome P450"
                     /protein_id="WP_068405123.1"
                     /sec_met_domain="p450 (E-value: 1.3e-17, bitscore: 61.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTGIILDWNTIEPYTFYTQRRATHPLYYAKAQQSWLIYAYPQAK
                     EVLLHQDALIPELNTSQTGLNKNAVQLIQQLARLNNFEQHQQSRAAALQIYNQMQPVAT
                     QDLLDLLLKPVITGIPVDWVEVVCKRLPALYILKSLNVEAKDCTFLIDHLPVLVKIMSP
                     QQNPATIKQLNELINLIFPLLEKYLPDGAFAPNYIAAEEWETLLVSNLIGLLIQSYDAG
                     RGLLTNTLLQLSNQQLSLSEAENYFEQAVVETLRFDPPIHLTRRVAGKDLLINDQLIKK
                     GEMIIILLAAANLDPQIFESPLTYNPSRGNNKAHLTFGAGHHQCLAKHLTMRLTAETFK
                     ILYHQIQILPQSFTYEPLLNARLVKNLFIIFKNQEK"
     gene            complement(16229..16576)
                     /locus_tag="AY601_RS21905"
                     /old_locus_tag="AY601_4429"
     CDS             complement(16229..16576)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010602098.1"
                     /locus_tag="AY601_RS21905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4429"
                     /product="hypothetical protein"
                     /protein_id="WP_068405128.1"
                     /transl_table=11
                     /translation="MEQPAEMNTLSQILEKLRQKGLDNEIKMTDHGKMQGVGLHKIYLP
                     EDLTIIKTYRFEGDSDPADNSVLYLLEDKDGQIGYIMDAYGMYSSQEGTGFDDFLKKIP
                     TADRDLQELFK"
     gene            complement(16629..18176)
                     /gene="treF"
                     /locus_tag="AY601_RS21910"
                     /old_locus_tag="AY601_4430"
     CDS             complement(16629..18176)
                     /GO_function="GO:0004555 - alpha,alpha-trehalase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005991 - trehalose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008505183.1"
                     /locus_tag="AY601_RS21910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4430"
                     /product="alpha,alpha-trehalase TreF"
                     /protein_id="WP_068405130.1"
                     /transl_table=11
                     /translation="MIRKIIFILFIGLQLGRVSAQTKTPDALYGQLFIDVQMQNVLKDG
                     KTFVDCIPKRDPARILEDYMKLKAAKTKFSTKAFVNDNFILPDTNTTVVIQANQPVTEH
                     INQLWEALRRKPAEKIANSSLLDLPSPYIVPGGRFREVYYWDSYFTMLGLQVSGENETI
                     ENMIKNFAYLIEQNGHIPNGNRNYYLSRSQPPFFSLMIGLLAQIKGNKAYSTYLPALEK
                     EYAYWMDQSAATKHVVIMPDGSKLNRYYDQLNTPRQESYKEDVLIGKQAEAKNPEVYRD
                     IRSAAESGWDFSSRWLADGMQLKTIQTTQIVPVDLNCLLYNLELTLQKCYALQHNVAKE
                     KEYQALALKRKASIQKYFWSPKYSWFTDYNLKTKKQSSILSLAGMFPLSFNLVDQKQAK
                     LVKNILQQKFLKAGGLVSTPLNTHQQWDAPNGWAPLQWMAITGLGNYGFHTLEKQISVR
                     WINLNTSVYQRTGKLMEKYNVVDLQLKAGGGEYTSQDGFGWTNGVLISLMKKYGYMK"
     gene            complement(18418..19686)
                     /gene="metK"
                     /locus_tag="AY601_RS21915"
                     /old_locus_tag="AY601_4431"
     CDS             complement(18418..19686)
                     /EC_number="2.5.1.6"
                     /GO_function="GO:0004478 - methionine adenosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006556 - S-adenosylmethionine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="metK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003013032.1"
                     /locus_tag="AY601_RS21915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4431"
                     /product="methionine adenosyltransferase"
                     /protein_id="WP_068405133.1"
                     /transl_table=11
                     /translation="MSYLFTSESVSEGHPDKVADQISDALIDNFLAFDPESKVACETLV
                     TTGQVFLAGEVKSKAYLDVQKIAREVISKIGYTKGEYMFDSNSCSVLSAIHEQSPDINQ
                     GVDKEDKTTQGAGDQGMMFGYATRETENFMPLALDLAHKILIELAAIRRENTEITYLRP
                     DAKSQVTLEYNDNNEPVRIDSIVVSTQHDDFDEEQTMLKKIKEDIINILIPRVSSQYPQ
                     FSKLFNKDIKYHINPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKV
                     DRSAAYATRHIAKNLVAAGVADEILVQVSYAIGVAQPMGIYVNTYGTAKVKAADGKLLT
                     DGEIAKEVEKIFDMTPYGIETRLKLRNPIYSETAAYGHFGKNNEVITKIFKASNGTEKE
                     VTVELFTWEKLDFVDAVKKAFSL"
     gene            19919..20818
                     /locus_tag="AY601_RS21920"
                     /old_locus_tag="AY601_4432"
     CDS             19919..20818
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008246402.1"
                     /locus_tag="AY601_RS21920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4432"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_068405142.1"
                     /transl_table=11
                     /translation="MAKSNILFIINPISGGKDKLKIPAIIDANLDRSKFNPNFSFTEYV
                     GHAAEIAEEAANKNFDIIVAVGGDGTINEIAAKVMQQQKILGIIPFGSGNGLARFLKIP
                     MNTAKAIQVLNELIVTKIDTGTFNDKFFFNMAGMGFDAHISSVFVGNKKRGLTGYFKLG
                     LKEMINYKPETYHIRVDGVGYTRTAFVVSVANSSQYGNNAHVSPHASVTDGLLDVCIIK
                     SFPLYKIPLLAYHMLNASTDKSDLVEIIQGKEIQITRVDDAAIHIDGEPYFMGREIEVT
                     ISPLSLNVIVPAAMGVII"
     gene            20829..21182
                     /locus_tag="AY601_RS21925"
                     /old_locus_tag="AY601_4433"
     CDS             20829..21182
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015809891.1"
                     /locus_tag="AY601_RS21925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4433"
                     /product="translation initiation factor"
                     /protein_id="WP_068405144.1"
                     /transl_table=11
                     /translation="MKPNKKSLSDLGGIMYSTDPSFSYETENETPQEVIANNQQDLRVM
                     LDRKNRGGKAVTLVTGFRGNAEELEKLSKMLKTKCGVGGSAKDGEVMVQGDFRDKVVLM
                     LQKEGYKVKKSGG"
     misc_feature    complement(21278..21298)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.95"
                     /tool="antismash"
     gene            21316..22920
                     /gene="pckA"
                     /locus_tag="AY601_RS21930"
                     /old_locus_tag="AY601_4434"
     CDS             21316..22920
                     /EC_number="4.1.1.49"
                     /GO_function="GO:0004612 - phosphoenolpyruvate
                     carboxykinase (ATP) activity [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /codon_start=1
                     /gene="pckA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015809890.1"
                     /locus_tag="AY601_RS21930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4434"
                     /product="phosphoenolpyruvate carboxykinase (ATP)"
                     /protein_id="WP_068405147.1"
                     /transl_table=11
                     /translation="MSKVLMPEPDLSRLNLGNDNAYYQLSVPELVEQAINNGEGTLSSS
                     GALAIDTGKFTGRSPKDRFIVLDDITRDSVWWGDINIQFSQSNFESLLHKVCAHLNKDK
                     FYVRDAYACADEAYKMSLRVITETAYQNLFANNLFLRPAEGEVIENPEWTIIAAPTFLA
                     DPAIDGTRQANFAILNFTDKIILIGGTGYTGEIKKGIFSVLNFILPELKSTLSMHCSAN
                     VGAEGDTAIFFGLSGTGKTTLSADPARGLIGDDEHGWGDSSVFNFEGGCYAKCVDLTAE
                     KEPQIYNAIKFGSLLENINYFPGTRTVDYSNIEKTENTRVAYPINYIDNAVLPSIAGIP
                     KNIFFLTADAFGVLPPLSKLNPGQAMFHFISGYTAKVAGTEAGVTEPQVTFSACFGKAF
                     LPLHPTKYADLLGKKMEEHKVNVWLVNTGWSGGAYGTGSRMKLSYTRALITAALNGELT
                     SATFTEHPVFGLQMPDACPGVPSEILNPRNTWSDKQQYDHKANELAKAFIDNFKQFEEF
                     ANDEILKSVPKVVENTL"
     misc_feature    23085..23099
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            23200..24027
                     /locus_tag="AY601_RS21935"
                     /old_locus_tag="AY601_4435"
     CDS             23200..24027
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015252 - proton channel activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003000225.1"
                     /locus_tag="AY601_RS21935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_4435"
                     /product="MotA/TolQ/ExbB proton channel family protein"
                     /protein_id="WP_068405149.1"
                     /transl_table=11
                     /translation="MANAPKPTTVKKESSSASNLFATLVIPICIIIAALIYKFVLGDAN
                     NFIDNNVENLPKVGNYAGMAYKGGPIVPILMGMLLMVVVFSVERFIVIGKATGTSSLDA
                     FVKKVQALLNSNNIEAAMAECDKQQGSVANVIKSGLKKYREMEVETNMDTDQKCLAIQK
                     DIEEATTLEMPMLEQNLTVIATLVSVGTLMGLLGTVTGMIKAFGGLGASGAPDSAALAT
                     GISEALINTATGIGTSTLAIIMYNILTSKIDKLTYAIDEAGFSIIQTYASTHK"
ORIGIN
        1 acagttgtgg catacatcaa tagctgcacg ccaaaggtga ctaagaatgc cagatcgcgg
       61 tatttagtgg tcattgcaga gatgatcatg cctaacccta aacccaggca ggccatgagt
      121 aatacaatta ctggaaataa aaggataaac caatttggac caaaatgttt accaatgatc
      181 agataataaa cgatcatgat tataaataac agtaattgta cactaaaacg tacaaggtta
      241 gacactacaa tgctcaaagg cataattagc cgtggaaaat acacttttcc aaatatattg
      301 gcattgtcct taaatacggt actggtctta gtcaggcatt ctgcaaaata attccatgca
      361 gtaatacctg ccatatagaa taaaggttgc ggaagtccgt ctgtagaaat acccgccaga
      421 tttccaaaaa taaaagtgaa gataatcgtg gtaaaaatag gttgtataaa aaaccatagc
      481 ggccccagga tggtctgttt ataaaatgat acaaaatcgc gtctcacaaa aagtaataac
      541 agatcacgat aataccatac atccttcaac cttaaatcaa acaggttgtt ctttggggta
      601 atctccatgt cccagttttc ttcaggcagt tgctccattt tttatcaatt tttctaaggc
      661 attgctataa tcctgtggat taaaatattt taggcattgc tgctgaatac tttttctttc
      721 agcaattgtt aaaggatgcg ctaatttctg acggattgtc tgttctaaga gcgcactatc
      781 gtcaggatca atagcggttc ccatttcttt gttgcgtata gcatctacgc tgccatctgc
      841 attaccgcag attacaggaa gtccaaatgc catggcttct ataaaaacaa ttccgaatcc
      901 ttcttttttg ctgggcatca caaataaatc agccattaaa aagtagtcgg ccaaggctgt
      961 ttcttcaaga taacctgtta atataaaatt gctttccagc tgctcatcct ttattaattg
     1021 caagattcgt gttttttcat tttcatcata agggcctgca agaatatact tcacctttgg
     1081 aaagctttct ttaatcctgc ttactgcttt tatagtttgc tcgtatcctt taaatttctc
     1141 tgttgaggtg atgcgtgata agctcagtat aactttatca tgtgccagca ggtcgtaacg
     1201 ttttaataaa tgtgcaggct tcacaaaaaa atcaggcagc tttgtaaaag gatccagcgc
     1261 atggtttaat accacacatc gatcagggtc aacaggatgc atctccacta tttttctctt
     1321 ggtaaaatta cttacacata taatttgatc cgctatgccc cagattgctt ttttccaaaa
     1381 ttttaagggg cgccatacct ctacaccgtg agtgatcaac catattttac aggcaggatt
     1441 cagcagtcgg ataaggcagc ctatggagga aagatgaaca tggcttaaaa tgattaaatc
     1501 gctattcatt ccggctttta aactatgcca taggtaattt aatttacttt ttttaaaagc
     1561 tttaaagtta gccataggca gatagttggg caggagatct gactgttcat catgtaaagc
     1621 gtacacggtg acatcccaat ggttcttttt gcctaactgg gacaatgtat aggacattgt
     1681 ccggttcatt ttctgaattc cgccagttcc gccaaaagtc tcaagggtta aaaaaagtat
     1741 ttttttagac atgaatcatc taccttttat tattcataat tatgcacagc ttcgcctctt
     1801 tagtcacatt tatttacgta actatttata aaccattgca ttaattgcac ctaagaatcg
     1861 gtgtttattg cagtctttct atcaaggatg ctgggacatg cacaatgata ttgtatttga
     1921 tatcgcctaa tctcaggagc aactgctttt gagaatggta tttaataatt tctccatgca
     1981 ttccttttag ggagcctgct ttaataataa ttttttctcc tggcagcagt tcatcttctg
     2041 taatttcaaa ttcataagca cttgccagta ctaatttgag ttcctctatt tgccggtcag
     2101 gcattgatgc aattttgcct gaaaaataga ggaaacgtgc aactccgctg gtcatcaata
     2161 cctcagtttg ctgatgctga tgtatatgta caaaaacata agatttaatc aatggctctt
     2221 ctacccattt tttcctgtca ctccattgtt tcatctgacg gcgcaaaggc agataggctt
     2281 caatatcttt gttcagtaat tcctgatatg ctttcttttc cgaccttgag tgggtataaa
     2341 ctggatacca ttgctttctt tctttatctc taatgtcagc catctgatta aattaagatt
     2401 taaaccaatg cttgatgttc caccatttta atttttcttc ttcatctaaa tagtaaccgg
     2461 aattttcata gtcgtattgt gtatctgaac taaaactacc actgtactta tataatccgg
     2521 catgtaaaag gtttttttca aaggcattta atacaatcac gaggttattt aaattatatt
     2581 cctttgatag cctatcaggt aatgtagctg aactgtattt tgattttccg tagcggatta
     2641 caaacaggtt gatgtcgctc atactgatca gcggaactga gtctgagacc aggcccacag
     2701 gagcagtatc tattaagatc acatcatatc tttctctcaa ctggccaatt agttcggcca
     2761 tccgttcaag atgcaataat tctgaaggat ttggcgggat agggcctgag cttataaaat
     2821 caagattttt ggtgtttgat tcttgaatga tatcatctat gccacatttg ttgacaaggt
     2881 aattgcttaa gcccatggcg ttaggcttac caaaggtttt atgcagtttc ggtctgcgaa
     2941 ggtcggcacc aataagtaat atttttttgt tgatcaaggc gaaactgctt gccaggttaa
     3001 taattacaaa agattttcct tctcctgcgc tttccgaggt aatacaaatg accttacttt
     3061 tctttcctga ggcgagaaaa ttgaggttcg tacgtataat gcgaacggat tctgcaaaga
     3121 tagaccgtgg tttacttaag gaaagtatct gactattgtt ttcatcaatt ttttccggga
     3181 actttctgag ggcacctaaa attggtatcg aagttgtcct ttcaatgatc tccctgtcat
     3241 aaatgtaagg attggatatt ctgatcacta taataatccc aatgccggct aagaagccca
     3301 atataacagc ggtacggtaa atctcatcgg tattaggggc aataggaact gtattcagct
     3361 gtgccttttc aacaatgatt gctcctggta agatagcagc gcggttaact tgtgcctcaa
     3421 ggcttttttc ggataaaaaa gaatatacct tttcattaat ctcgaaatta cggtttaagc
     3481 caatcaaatc tttttctgct gttggaagca aagctacctg ctggtttact tttgctaatt
     3541 gatcgttcaa gtaaccaata cttttctgaa tgcgctgatt tgaagcacta atattgcgca
     3601 ttgcagattt tttgacctgc gaaatttgtc tgttaatctc ctctacaggt tgcgacgtac
     3661 tgtggtagac ttttaacagg gcatttttat cgtttattaa agtattgaaa ttgcctacaa
     3721 gaacgcctag taagggatca atacttccct ccaggttaag attaaggttt actgcatttt
     3781 tttctgcagc tatttgttct ttcagttgat caataacaat gagttgcatt ttcagcaagg
     3841 aacgctgcga ctccagatca ctgactttgc tgaatgcaat tcctgcagat gaactcacgt
     3901 ccatgatctt tgtattctcc ttgtattttt ccaatgaccg ttctgatcct ttcagctcag
     3961 tggaaaggta ttttaactga tcggtaataa agtcgatcaa ctgtgtcgca gattgtgttt
     4021 tctggttacg gtcaaaattc aggtattcct tcatgatcgc attgatgata tccattgcga
     4081 actgaggatt agcatcagtt tgctgtagcg tcagaagatc tgaattttta atcgcctcat
     4141 tgatccgtaa accactacgt acccgatcta aaaaagattc aggaatattg aatttaaaca
     4201 agtaggagat attcgggtta actgatcccg gatagccgat ggtaaaggta acagctccga
     4261 tatttaccgg ataaccatat ttgaaatttt gctggacttt gttatttccg attttccagc
     4321 tcaattcaaa tttattttta tttattggtt taaaggcgat cagatcctgg taaaaattca
     4381 ggctatcaaa ttttaataaa ttgatctgaa gcggcttctt tgggtacata tcataggtac
     4441 gtacccttcc cgaaagataa aagctggttc tgtaatccag gtttttaatg gcctttaata
     4501 gcaggctacg gctttggatg gtaaaacttt cactttgcaa attgacagta ttccgatcgg
     4561 aattgcccat tgttccgatg atgtcagaaa gttctggttt tttttcttca aatttaagta
     4621 atccgttcgt ggaataggtt tttggagtat accataaata gagatttgcc gtgattaaac
     4681 cgattataat tgggcccgct atcaggtacc agctgttaaa caatatctta attattttta
     4741 gatagtcaac ttccttgcta ttcaggtatg tttgggccgt ttttacttct tgcattatcg
     4801 cgttatcgta taaatgatca gtgcagtatt taataacaag ataattggtt gcaatataga
     4861 agagaagcct gtcacttttg tagtgcgtac agcttgttta ttttgtgtga cgtaaataat
     4921 gtcctcgttt ttgaggatga tcctgggatc ggagagcgta gtgagattac ttaaatccag
     4981 atcaatcacc tcttgatttt ttattcctcc ccgaattatt ctcacgtttt tactgtttgc
     5041 ccgctcggtt aacccacctg cctctccaat catttctatt aatgaagtcc ggtcttttac
     5101 cagcgtatag ctaccctgag ttttaacttc gcccaggatt gttaccttca ggtttactat
     5161 ttttaggtca ataatagggt ttttgatttc tttactataa atattttcaa ttttcttggc
     5221 agcatcataa cggttaagcc cctctacttt tacacgtcct atgatcggga gtgctaccgt
     5281 cccatcactt tctaccaaaa aggtctggcc atctgtactg ttggcgccct ttgcggctga
     5341 tatagttgta gtaggttcat caacaatata tttagggctc tgcaggtttt ttatttgaag
     5401 cagatcctgc ggttgtatct tataggcact tgtatcagta atagttgggg tattattgaa
     5461 agcctgtctt ctattctcaa aaagagcctg ttgctgttta acagaacatg aaaaacagct
     5521 ggtaagaaga ataaagataa atgcataaag tatgtattta tttgaaggca taaatattta
     5581 ttataatggt ttgtatcata ctttatgaat ctaaggtagg taatcattta ccattaaggg
     5641 gtaatttcat tttgcacgat ttgtaatatt tttgatacaa aaaaataaat attgaattaa
     5701 tcctaagttt aggagtgttt taaattttaa attaatttac cataaagtta ttgtattttt
     5761 ttgttgatta atattctact tatttagttt aaaatataat ttgagtgata gatatttggc
     5821 acacattctt actattgctg tcatttgatt gatcagaaat taatattttt ccatctgtac
     5881 ttgtcgttct aagttcttga agtgtgtctt gtttgctaac tatctcatta ttataattat
     5941 gtttacttta tcattgcata tttacttcat atagtgcacc aaccaaagat ctctttaatc
     6001 acagtcacct ataatgcagt ggaaacattg caacgctgta ttgaatctgt aaccaatcag
     6061 acttatggca atttagaata tattatcatt gatggtagtt caacggacgg tacattgaaa
     6121 attattcaga ataaccaaaa atatattcat gttttcaatt ctgaacatga caatgggatc
     6181 tacgatgcaa tgaataaggg tattaatctg gcaaccggtg atatcattgg taccctcaat
     6241 gcagatgatt attttgctaa taatgatgta ttagaaaaga tagcgcaagc atttaatact
     6301 gatcatagag aaatgttata tgcgaacctt aattatgtaa ataagcatgg aacagtagtt
     6361 cgtaagtggc gatctggaaa atataaggct actaaattta actggggatg gatgcctcct
     6421 cacccaacat tttatgtaaa gaaggacttt tttgataaat acggtttgta tgatctcagt
     6481 tatggaactg ctgctgatta tgaacttatg cttcgtttta tgtatttaaa agccgtaaat
     6541 gtgttttttc tcgacgaagt aatcgtaaat atgactattg gaggagtgag caacaggaat
     6601 tttagaaaca gaattagcgc ctgggcgggt gattttaaag cgatgaaaag ttgtcaacta
     6661 ccgattccgc ttttaggggt gattttcaag ccgatacgaa aaatactaca gttcatttaa
     6721 tataaaaata ttttttatgg aaacatttga tttgccaatt tatttaaaca accatccttt
     6781 aatttgttgc attctggtat ttgtatcttc tattttaatt actctggcta ttattccttc
     6841 tattattttt gttgctaaaa ctcataattt atacgataac ttcagctatt tcagaaagca
     6901 gcatctgggt gctattccgc gcttaggcgg agtagggata tacactggtt ttactgttac
     6961 tttactgttc tttgatttaa cggataaaat aaccccgatc aattatttgc ttgcttcctg
     7021 tatgatattg tctattatgg ggattaagga tgaccttctt ggagttaatc cgcgtacaaa
     7081 actcatcatt cagttaatta catcgctgat tttggttatt ccaggaaata ccaggatcag
     7141 tagcttacat ggggtattcg gcctctacga tatctcctat cctgcaagtg ttgtattgtc
     7201 tctgctgact atcatattca ttattaattc cttcaatttg attgacggaa ttgatgggct
     7261 gtcagcgatg acaggcatta ttgtgaatag tgttttttca gccttattta tatatatggg
     7321 caaatatgaa ttagctgcca tttcgttagc aatgactggt gctattatag gatttataca
     7381 atttaacatt actccggcaa aaatctttat gggggatacc ggagcattga taatcggatt
     7441 gatatcggcc gttatggcta tcaaattttt agaattaaat aagtttacac cagatcacaa
     7501 tcctgatgtt ttccctgctc cggctatagc actggctatt ctgattattc ctgtttcaga
     7561 ttcattgcgc gtgtttattt taagaatttt aaaaggaaaa tcaccttttt tggctgatcg
     7621 gaatcatatt catcaccgga tattaaaatt aggttttacc catatgcaga ctaccacact
     7681 tttaattggt gttaatctat tgatgatttt aatcgcatgt ctctttgcca gttatggcaa
     7741 tgggttcttg ctgatagtta tttctcttat tgcattaatg ttaaactgga tactcagtta
     7801 cctgatacgc tccaaagaac gtgaaagtta tgctttacgt aacttatttt tataagatat
     7861 atcaggtctt ttgctgaacc tttctggagt tcttgacaat ctttcgtgta ttctcctctg
     7921 tctgctaatt aaatcaacta aaaaataagt ttaaaagatt acataaaact ctatttttgg
     7981 gtaaattcct acgaaagaga ttatgctgga taaaaatgtt ttgaataaaa cggagccgaa
     8041 aaacaggaaa ctaactgagc gaaagcttat tgatgcagta ggtgaaatta tccggtccac
     8101 tggatataca gggctgggcg taaatgcaat tgccaaaagc gcaggtgtca gtaaaaaatt
     8161 gatctaccgc tactttggta cagtagatgc tttaattgaa acttatctca tcgaaagaga
     8221 ttattgggtc actttttcta aaaaagtgag tgatgcagca gtagcttcta ataaaaaaca
     8281 aaccatgatt gagttttcgt ccagcatctt cgaaaatcag tttgatttct tttttaatga
     8341 agatgaaatg cagcggatta tcctctggga gatctcggaa aaaagtaata ttttaaatga
     8401 gctgagcaga aagcgcgaag ccatgggaga agaactttta aagttaacgg atccttattt
     8461 taaagactca gatatcaatt tcagagctgt ttcagcaatt attatatgcg gaatttatta
     8521 ctctgtgtta catactaaaa agaatgcaag taccttatgc ggacttgacc tgaataccga
     8581 ggcaggaaga aaagagatta ctaaggcagt aagaaaaata gtagagctgt gttttggaag
     8641 taaaaagaaa aaagcaaatt aaaagatacc tcatggctaa acacacctaa agccatgagg
     8701 tatactcatt aatgttggta agaacgattt ctaatcttct caaagattca cacatcacaa
     8761 agttagatca cattaattct ctaagtggtg acataagcta aaaataattc aattattttt
     8821 agctcaaata tttattcaaa tatctatcag tcagcatgtt gtgttttctt ttgctaaaga
     8881 cgtggataaa attatttgac aggtcatttc aaaattgaaa attgaacgct gaaaatcact
     8941 ccaaagtcaa caatagaccc tcttcttttt ttaactggaa tttcttcatt cacagcgaaa
     9001 gtacttgcca gttgaaaatt cctgatagca ggtgcgctga gctttgcttt ttttggatca
     9061 atccccaaag ctttcctaga taacttgatt agaccgatta ttaactatcc atgtgctttt
     9121 tacaatctgc aggagcttcc ttagcctagc ttgccagggc aatcatcttt tcttcgccat
     9181 tcaataactg tttttgccac tgcactggcg gtacttatag ttataactgc acgatggttg
     9241 cctaatgaat caggattcca actgttggtt ccaattttat agtggagttg ctggcctgag
     9301 caattgcgaa attgatactt gaaagtagag caatgccaaa gatagctttt gttagaaatt
     9361 ttgcctgaat tgatttgaac atggtcttcg aaggaatatt ttcctaagct gagagtattg
     9421 attttaatca cgaaacacct gaaatggccc ggatttggga ctgaaaaatt aaggcaaatg
     9481 tttgacattt agcttggtta gactataaga ttgtagcttt cattcagtcg tataataatg
     9541 ccagagtagt caggttcgat agactattct ggcattgaaa attaacaaac tctaattcct
     9601 ggtaaagtac cgcaacttct taacgtatca ttataatctc caggagtacc acaactacac
     9661 gtattaggat ttggtagtgg atctgcggtt ccacattttg cgcctgcagt ttgacactga
     9721 taagtactga cgtccatagt tacgggggca cttcctcctt ttatagcact caggtcacca
     9781 ataatctgtt tatcgaatat tagttgtttt tcaatctttt gttttttcat gattttaatt
     9841 ttacaaatga taattggtta attttgttaa tttaagtttt atgtaattta gtttattagt
     9901 ttctgatttt atacataaat ttatttattt ttatgaatac acgctattat aattcttaat
     9961 taatcatgtt aattgccttt agtataaaaa ggagtattta ttatttttct ttataagatt
    10021 cttctaaaaa atacctatgc atgaaatcat ataatatata ttctgacacg ctattatctt
    10081 taatgaaaat tcgatttaat gacatatgaa aaaaacttgt aataagtctg ttggctggga
    10141 taaagggtga attgtgggca aaattagata tcaacgattt aatcacaaaa gattgacttg
    10201 atgaatcacg ttgatgtaaa gtaaatagtt tattgtaatg tgcatcatct gaatttaata
    10261 gatcggccag caattttcgc ttatttttgt acctgtttgc tatttcctta ctgtccttag
    10321 aactgatata atattcattg ttaaagtttg actttagatt ttttaagaaa tctattcttt
    10381 catatagatc aaaatcaaat agatccaagt aatgatttat taataatgct gcgtgtaacc
    10441 atctggaatc gctatttgta ctgaggtcaa ttgaacttag aatttgtaga acgttgaggc
    10501 tatcatagaa aaaaaactgc tcagataact ccattgtaaa atcaccgtat ctttctatct
    10561 ctcgctggta agtatcaatt tgaatagaat taatacgctc atccaagacg tacttattaa
    10621 aaagattatg aaatacactg ataataaaac ctaatttttc aacatttttg agctttattc
    10681 ttaacctaat atgaaattca ggatcattat atcttataaa aaaaaatgaa tcgatctcgt
    10741 tatcttttat taatttctta agggttttgt aaattgaatt agcaagaaga ttatcagctg
    10801 tgctttcact taagtaaatt ttataacata gccattccga accaacaata tatttcctag
    10861 acacctgatt atgcattttt atagaatgaa attattaatt cgtgacaatg gttctgattt
    10921 gtaacatttt taactaagct ttcttctttg aacaaaaatt cctttagtaa tattgtgtta
    10981 ctcttaagta gcttatttag aaaaatcttc acagataact gattctcaaa atcaataaga
    11041 agttcattat ctccttcaca tagcaatact agctcaggca gtttaaattt atttctaaag
    11101 ttgtttatcg aatttactaa agcattggtg tcttcttgat taataccctt aagtgtaggc
    11161 tcattgaact taataaacca gcgtgcctca agaacgatac aatttttata ttcaattctg
    11221 gggatgtgag aaaacatttt ttgcagatca tccaaataaa atcctaaata atttcttttc
    11281 ccatataatt ggaggtctgt aagaaatcta tatacaggta tgtttgattt tagactgttg
    11341 tgggcattag gtaaaaatgg tttaataatc ttattaagtt ttttagatct taattctatc
    11401 ttcatatcgt ttgttaatct taccataata tcctcaatcg gtataggatt ggctacagtt
    11461 gatagtgggg ctgaaagtat agggatgaaa tgatcgaaaa tatgcttttg ttcaaaaaca
    11521 tttgttaaat gaatattagg agcatgaatg atttctgcat taatgtagcc ctttctatct
    11581 gcattctcat tctctttttt aacgatgtcg cttactaaat atttggtcgt tttatcctga
    11641 taagtgaatc tcgtaagtag atttacagct gaaggccccc caaacccatt aatgacaatt
    11701 ttttttccat ctgaagtttg caggattttt atattcgcat aaatagtatt tgggatatca
    11761 tcccagttct cctttaaatc ttcaaagtca gaatcataga gctcgattac cgttttgtta
    11821 tgggtataag ctgaaagaat tctttcatgt agaatagagg tcactgtatt ccatcggatg
    11881 atatcgcttt ttcgttgttt ttgttttatg tttaaatttt caatgagtgg attagatgat
    11941 atttgatggt ggttaattgg ataacctaaa cctatatcgt tatccatcaa tgtgacaata
    12001 tttacttctc taaactcata ttttttgtag aaagactgtg taaattgctc taattcaggg
    12061 ttgtttatag ctgttgttat cttgttgaaa aatggtaaca aacttttgat ttttaaaaat
    12121 gtggttttat ctaaagtatt tatgccatcc ttcattacta ctgttgattt tatcggagaa
    12181 aaattaatca gaccatcaac tgaatttttt ttgatatcta tgatttcatt aaatttttgt
    12241 atatctaatc catcactatt tatatctttc agaatttgag tatatttatt tacaatgtca
    12301 cgcaataaaa tgttgtcaat tagtttgttg gaaagtgaca caatttttgt aaaataatct
    12361 tcccttaatg tgggttgtat ctccgttaga agaagcttat taattattaa tgtatctaaa
    12421 tatgccaatg cgtcactctt ggaatatcct tgtgaaatta aatcatcaag caatatccct
    12481 aaagtacaac ctgttttagt cagttttaga attcttgtta aataagtatt attactagtt
    12541 attacctctt taaatgttct ttctccttta ggaaagttat caaagaattc gatgaattta
    12601 tatcttttgt catgtccaaa taacatatta tttgaataaa tattcatgtc tgaaaattta
    12661 tcaggttcta atctatataa cgcagttact aattcgtata aaaaggtatt atcatattga
    12721 taatttaaag tgattttact tgaatcaata acgatcttgg attcttttcc taattcgcca
    12781 acagaaatcc cagaaaaaag accaaaaggt gtacttcttg tgctcattcg ggatagatat
    12841 ttcatcaaag tactattaaa cctcactttg tctttggtat taatttcaac atgattttta
    12901 atttctatag ctttaagctg aagatataga tcaggtgagg aaattaaaat ggccatttgg
    12961 aaatatttat ttaaacaaaa aaagttaaac atattatctt catgtattat ctccttaatg
    13021 ccgtcaatgg aataaaccgg gaatcttaag aaatatttat cgaaatagtg ataaggattc
    13081 ttcattagta atgctatatt ttaaattaat gtctctatta ttaccatctt aactgggacg
    13141 ttgagaatta tatcatcata gattgtttcc agtttaattc ggtgtcagat atcagtgata
    13201 ttatacccag acctattcct gctataccgt ctaaaagatt gacctcgttg atgtatttat
    13261 tgtaatcata ttttttaaat ccacccaatc cgtctgggaa acttcctttc attagaccat
    13321 catttaacca ataattggag gcttggctaa aatttttatt tgaagttata tcataaaagc
    13381 tcttgtaaat aacagcaatg cctaatgatc cgtgacataa tccactatct actactcctg
    13441 tttccaggag agatcttctt gaacagcact ttatcatgat tctttcactt tcttttagta
    13501 agtcttgtcc tttgataaat ctactggcat tcatgaaggc actggcaatt cctaaatcac
    13561 cataacacca cgccattctg cttgcctcgg ctaaatgcgg atcgattaaa ttaatataaa
    13621 tatttttggg atatgcagaa tccaactgat cgttcctagc agttaaaagg aaattagttg
    13681 ccagatctag catttttagg gcttttggac tttttatatt atatgacaaa acgttggtta
    13741 ggaaactaat tatacctgac atgccatggg caaatcctgt atctactgag tttttgggaa
    13801 atccctcaaa cgtatttatc caataaatac cattttggct tttaaaagaa aaagcagaaa
    13861 gaccatcaat caagtcatga atatagttta ggtatttctg ttttagtctt tttgagtttg
    13921 ttaaattata tctttttaag aagtaatatc catacccaat ggagcaatgt aaaaaatcaa
    13981 attgaccctt cttcatacaa ctgttcatgt tttctgctaa aaattcatca atctcattga
    14041 aattttcatc tgaactaaat tgtataaaat tgtattcatt tagatattca attgtccagg
    14101 cagcacctgc aattccactg caataggttg gaaaggaata tccattgttg attctgtcaa
    14161 taatttctac tatatatttt tttccgaggt ctgaataata ctcatctcct gaatatttat
    14221 aataatgaaa gagaaatagg gcgattcctg agattccatt taatactccc aggttagggc
    14281 tattgaggta cttttcatct tttaattctt tagcaatttg ttttagcttt tctttcgcaa
    14341 gctcatattt cataattaat tttgtattaa taaaaacaga cgaaattcta taattaaata
    14401 gaatctagat tgaagtgcat ttttaattat acaatataat ctttattgct taatattatt
    14461 ctgtttattt aaattatttt tctattatga tctttgtttt tctctttgtc gatgctgatt
    14521 taatatggta agctagtggg catggaataa ataatgtagg taatttgaag cgattatcca
    14581 tgtgctattt tactatccgc aggagcttcc ttacggtcga acattccgta atctctaacc
    14641 acggttgcta ttcttaaatg ataatcatta aaaacggtct cccggccctg tgcttgtgca
    14701 tcccggtgca tttctatatt tctccattcc agaatcgctt tttcattttc ccaaaaagac
    14761 aaggacagta tcttatccgg atgtaccagg ctctgaaacc tttcaataga tataaagccc
    14821 ggtatagtag aaagttcagg attaagtttt gcagcgatgg acaggtagtc tgccatttta
    14881 cccgttgcag ggataacttc aaaaattact gcgatcattt ttcttgattt ttaaagatga
    14941 taaatagatt tttaaccaat ctggcattta agagtggctc ataagtaaag gattggggca
    15001 atatttgtat ttggtggtac aaaattttaa aggtttctgc tgttaacctc atggttaaat
    15061 gcttagccag gcactgatga tgacctgcgc caaaagtcag gtgtgcctta ttattgcctc
    15121 ttgatgggtt atatgttaag ggagattcaa atatttgagg atcaagattg gctgctgcta
    15181 ataaaatgat aatcatttct ccttttttta tcaactgatc atttatcaaa agatctttcc
    15241 cggcaactct ccgggttagg tgtattggcg gatcaaaacg taaagtttct acaacggctt
    15301 gttcaaaata gttttctgcc tccgataggg agagttgttg atttgagagc tgcaacagtg
    15361 tgttagtgag taatcctctt cctgcgtcat agctttgaat caaaagccca atgagattag
    15421 agaccagcaa tgtttcccat tcttcagcgg ctatataatt tggggcaaat gcaccgtccg
    15481 gcagatattt ttccaataaa ggaaatataa ggttgatcaa ctcatttaac tgtttaatgg
    15541 ttgctggatt ttgctgcggg gacatgattt tgaccagtac aggaagatga tcaattaaaa
    15601 acgtacaatc ttttgcctca acgttcaggc tttttaagat atagagtgct ggtagccttt
    15661 tacaaacaac ttcaacccaa tctacaggta tccctgttat cactggtttc aataaaagat
    15721 caagtaaatc ctgggtagca acaggctgca tttgattata aatctgcaat gctgctgctc
    15781 ttgattgctg gtgttgttca aaattgttca gccttgctaa ctgttgaatt aactggactg
    15841 catttttatt caggccagtc tgactggtgt taagttcggg gataagggca tcctggtgca
    15901 gcaagacttc tttagcttgc ggataagcgt aaattaacca gctttgttgc gctttggcgt
    15961 aatagagcgg gtgcgttgct cttctttgag tgtaaaatgt atagggttca attgtattcc
    16021 aatctaaaat aattccggta tccatgcttg ctttttgttg acttcatcaa aattagctaa
    16081 ccagaaaagg ttatacttca ttctaaaatg aatcgtacgc aatggatggg aaattaatta
    16141 gcacagctaa tttttaaagt ggaattcggg aaggaaaaat gctgaatgca taaaggaaaa
    16201 cagcgcctgt tttcctttat gcatctggct atttaaataa ttcttgcagg tctctgtcag
    16261 cagtagggat ctttttgaga aaatcatcaa aacccgttcc ttcttgagag ctgtacatgc
    16321 cataggcatc cataatgtag ccaatctggc catctttgtc ttctaacaaa taaagcacag
    16381 aattatctgc cggatctgag tcaccttcaa aacgatatgt ttttatgata gtcagatctt
    16441 ccggtaaata gattttgtgc agaccaacac cctgcatttt gccatggtcg gtcatcttta
    16501 tttcgttatc taaccctttt tgccttaatt tttctaaaat ctggctaagt gtgttcattt
    16561 ccgctggttg ttccataata aagattgttt gcttattaaa caaagccttc aataaatggt
    16621 tttctttttt atttcatgta gccgtatttt ttcatcaggg aaattaacac accgttagtc
    16681 cagccaaatc catcttgaga ggtatattcg ccacctcctg cctttaattg caagtctacg
    16741 acattgtatt tctccattaa ctttcctgtg cgctgataaa cgctggtatt taaattaatc
    16801 cagcggacag agatctgttt ctctaaagta tggaagccat aattccccaa tcctgtgatc
    16861 gccatccact gtaaaggagc ccatccgtta ggtgcatccc attgttggtg cgtatttagc
    16921 ggtgtagaaa ccagtccacc agctttaagg aatttttgtt gtaaaatatt cttaaccagt
    16981 ttggcctgtt tttgatcaac caggttaaaa gacaaaggga acatccctgc caaactcaat
    17041 atggaggatt gttttttggt tttaaggtta taatctgtga accaggaata ttttggtgac
    17101 cagaaatatt tctgaatact cgcttttctt tttaaggcca gcgcctgata ttccttttct
    17161 ttagccacat tgtgctgaag tgcataacat ttttgcagcg ttaattccag attatacaat
    17221 aaacaattca gatccacagg aacgatttgt gtcgtttgaa ttgtctttaa ctgcatgcca
    17281 tctgccagcc atctgctgct gaaatcccag ccactttctg ctgccgacct gatatcgcgg
    17341 tatacttccg ggttttttgc ttccgcttgt ttaccgatca gcacatcttc tttataagat
    17401 tcttgtctgg gcgtgtttaa ctgatcataa tagcggttca gtttactccc gtcgggcata
    17461 attaccacat gtttagtcgc tgcagactga tccatccagt acgcatattc tttttccagt
    17521 gccggtaagt aggtagaata ggctttattt cctttgattt gagcaagaag cccaatcatc
    17581 agcgagaaaa aagggggctg cgatctgctg aggtaataat ttctgtttcc atttgggata
    17641 tggccgttct gttcaatcag gtaagcgaaa tttttgatca tattttctat ggtctcattt
    17701 tctccggata cctgcagtcc taacatcgtg aaatagctgt cccaataata aacttctctg
    17761 aatcgtccgc caggaacgat atatggggaa ggaaggtcga gcagggagct gttggcaatt
    17821 ttttctgcag gtttacggcg cagtgcttcc caaagttggt taatgtgctc agttactggt
    17881 tgatttgctt gaataacaac cgtggtattg gtatctggta gaataaagtt gtcattcaca
    17941 aaagctttgg tgctgaattt agttttagca gcttttaatt tcatgtaatc ttcaagaata
    18001 cgcgcaggat ctcttttcgg tatacaatcc acaaatgttt tcccatcttt cagcacattc
    18061 tgcatttgta catcaataaa tagctgaccg tagagcgcat ctggtgtttt agtctgggcg
    18121 gaaacccttc ccagctgaag cccgataaag aggataaata taatctttcg tatcataatc
    18181 tcatatttta attaataata cgatttattc tggctttacc gataaaacct ggattaaaac
    18241 cgctgatttc ctatcctttt tctggcttgt tcaacttctg gtatgaggta ttattagcta
    18301 gatagaagta tctatggatt cataggcaag ttaataagaa cctgaccagg acttaaacgc
    18361 aaaagagcaa tgcctgtgaa gacatcgctc ttttttctaa agattttact gaccggatta
    18421 tagagagaac gcttttttaa ctgcgtctac aaagtctaat ttttcccagg tgaacaattc
    18481 tactgtaact tctttttcag taccattaga tgctttaaag attttggtaa tgacttcatt
    18541 gtttttacca aagtgtccat aagctgcagt ttctgaataa atagggtttc ttaacttcaa
    18601 acgggtttca ataccgtaag gagtcatatc gaagattttt tcaacttctt tcgctatttc
    18661 accatcagta agcaatttac cgtctgctgc tttaacttta gctgttccgt aagtgtttac
    18721 gtaaataccc ataggctgag caacaccaat tgcataagat acctgtacca ggatttcatc
    18781 agcaacacca gccgcgacta agtttttagc gatgtgtctg gttgcataag ctgccgagcg
    18841 gtcaacttta gatggatctt ttcctgagaa tgcaccacca ccgtgagcac ctttaccacc
    18901 gtaagtatct acaatgatct ttctaccggt caaaccagta tctccatgag ggccgccaat
    18961 cacaaattta ccagttgggt taatgtgata tttaatatcc ttgttgaaca atttgctgaa
    19021 ctgaggatat tgacttgata cacgtggaat caggatattg ataatgtctt cttttatctt
    19081 tttaagcatg gtctgctctt catcgaaatc atcatgttgt gtagacacca cgatagaatc
    19141 gattcttaca ggctcattgt tatcgttgta ctctaaagta acctgagatt ttgcatccgg
    19201 acgcaaataa gtgatttccg tgttttcacg acggattgca gctaattcaa tcaggatttt
    19261 gtgtgcaagg tcaagtgcaa gaggcatgaa gttttcagtc tctctggttg cataaccaaa
    19321 catcattccc tggtcaccag ctccctgagt agttttatct tctttgtcta caccctggtt
    19381 aatgtcagga gattgctcat gaatagcaga tagtacgctg caagagttac tgtcaaacat
    19441 atattcacct ttagtgtaac caattttact gattacttct cttgcgatct tctgcacatc
    19501 aagatatgct tttgatttaa cttctccggc aagaaaaact tgtccggtag ttactaaagt
    19561 ctcacaagca acttttgatt caggatcaaa tgctaaaaaa ttatcaatta gtgcatccga
    19621 aatttgatct gctactttat caggatggcc ttcagaaaca gattctgatg taaataaata
    19681 tgacatttta aataattagg tatataatca acaattcttt aaaatggaaa tgaccccgta
    19741 aaaacaggca gtaaaatgaa gtgtatgaat ggttagcact tttttttacg tggttgcaat
    19801 cccgtcatgc taacataaca tcgcaaatca gtccaccttt atattgcaaa attactatat
    19861 atattcaaaa tagtcaaaaa atatcaatta ttttgtgcca taattaaatc atatcccttt
    19921 ggcaaagtcg aacattctat ttattattaa tcctatatcc gggggtaagg ataaattaaa
    19981 gataccagct atcattgatg caaatctgga caggtccaaa tttaacccta attttagctt
    20041 tacggagtat gtaggacatg ctgcggagat agcagaagag gctgcaaata agaactttga
    20101 tatcattgtt gccgttggtg gggatggaac aatcaatgaa attgcagcga aagtaatgca
    20161 gcagcagaag atcctgggta tcatcccttt tggatcggga aatggtttgg ccaggttttt
    20221 aaaaatacca atgaatacag ccaaagcgat ccaggtatta aatgagctga tcgtaacgaa
    20281 aattgatacg ggtacattta atgataagtt tttcttcaat atggccggga tgggatttga
    20341 tgcacatatc agctctgtat ttgttggcaa taagaaaaga ggcttaacag ggtatttcaa
    20401 gctggggctc aaagaaatga ttaattataa acctgaaacc tatcatatcc gggtggatgg
    20461 ggtagggtat accaggacgg cttttgtggt cagtgtggcc aattcttctc agtatggaaa
    20521 taatgcacat gtttcaccgc atgcttctgt aacggatggt ttgctggatg tttgtatcat
    20581 taagtctttt ccactttata aaataccact actagcttat catatgctga atgcgagtac
    20641 agacaaatct gatctggtag aaattatcca gggaaaagag atacagatta ccagggtgga
    20701 tgatgctgct attcacattg atggggaacc ttattttatg ggaagagaga ttgaagtaac
    20761 gatttcgccg ctctctttaa atgtaattgt accagcggca atgggagtta tcatttaata
    20821 ttattattat gaaacctaat aaaaaatcat tgagcgatct tggtgggatc atgtattcta
    20881 ctgatccttc ttttagctat gaaactgaga acgagacacc gcaggaggta attgccaaca
    20941 atcagcaaga tttacgggta atgctggacc ggaaaaacag gggtggtaaa gcagttacac
    21001 tggtgaccgg gtttcgggga aatgcagagg aattagagaa attatcaaaa atgctgaaga
    21061 ccaaatgcgg ggtaggagga agtgctaaag atggagaggt tatggtgcag ggagacttca
    21121 gagataaggt ggttttgatg cttcaaaaag aaggctataa agtgaaaaaa tctggcggat
    21181 aatacccttg ctaaatcttt gatattcaaa tgattattct atagtgtata tgccacaata
    21241 agtgaaatat ttcctttgaa atgataattt ttcaataaat atctccttag ctttgcctaa
    21301 acaaataatc attttatgag caaagtttta atgcctgaac cagacttatc ccggttgaat
    21361 ttgggtaatg ataatgcata ctatcagtta agcgtaccgg aactggtaga acaagcaatc
    21421 aataacggag agggtacact ctcctcttca ggtgctttgg caattgatac tggtaaattt
    21481 actggtcgtt cgccaaagga caggtttata gtgctggatg atataacgag ggattcagtt
    21541 tggtggggcg atattaacat ccagtttagt cagtcaaatt tcgagtcttt actacataaa
    21601 gtttgtgcgc atcttaacaa agacaagttt tatgtgaggg atgcttatgc ttgtgcggat
    21661 gaagcttaca aaatgagcct cagggtaatc actgaaaccg cttatcaaaa tctatttgct
    21721 aataatttat tcctcaggcc agcagaagga gaggtgattg aaaatccgga gtggacaatt
    21781 atagctgcac caacatttct ggccgatccg gctatcgatg gtacgcgcca ggctaatttc
    21841 gcgatcctga atttcacaga taaaataata ctgataggtg gaacgggtta tacaggtgaa
    21901 attaaaaaag gcatcttctc tgtattaaat ttcattttac ctgaattgaa aagcacttta
    21961 tccatgcact gttctgctaa tgtaggcgct gaaggggata ctgcaatttt ctttggctta
    22021 tctggtacag gtaaaacaac attgtctgct gaccctgcaa gggggttgat cggtgatgat
    22081 gagcatggct ggggagattc ttctgtcttt aattttgagg gtggatgtta tgcaaaatgt
    22141 gtagatctga ctgctgaaaa agagccacaa atctataatg caatcaaatt tggctctttg
    22201 ctggagaata tcaattattt tccgggtaca agaactgttg attattcaaa tattgaaaaa
    22261 acggaaaata caagggtcgc ttatcctata aattatattg acaacgcggt tttaccttct
    22321 attgcgggta ttccaaagaa tattttcttt ttgacggcag atgctttcgg tgttctacct
    22381 ccattgtcga aattaaatcc tggtcaggcg atgtttcatt tcatttccgg atatacagct
    22441 aaggttgcag gtacagaagc cggagtaact gagcctcagg taacgttttc tgcttgtttt
    22501 ggaaaagcat tcctgccttt gcacccgact aaatatgcgg atcttcttgg aaaaaaaatg
    22561 gaagaacata aagtgaatgt ctggttagtg aatacaggct ggagtggtgg tgcttatggt
    22621 acaggcagca ggatgaaatt aagttataca cgcgcattaa tcactgcagc attgaatggg
    22681 gaattaactt cagcaacatt tactgaacat ccggttttcg gattacagat gccagatgct
    22741 tgtccgggcg ttccttcaga aattttgaac ccaagaaata catggtcaga caaacaacaa
    22801 tatgaccata aagcaaacga acttgctaaa gcgtttattg acaactttaa gcaatttgaa
    22861 gagttcgcaa atgacgaaat actgaaatca gtcccaaaag ttgtagaaaa cacactttaa
    22921 atcatttttt ttaagcaaaa atttgcattt caattttttt ttagttttca ttgtgaaaga
    22981 ttgtctttta accgggacaa tcttttttaa taatagctac gcgacgatag atttattgcg
    23041 aaaatcaaat ttacctggta atgataattt aatttggaat taaaatcaaa gttgtagatt
    23101 tgttattgca acatttgatt ctattcgtcg ttgtgtgtat tacaagatat ttaatctaaa
    23161 tttaaaaaac aaagtactaa aaactcaaaa actaaaaaaa tggcaaacgc accaaaacca
    23221 acaacagtta aaaaggaaag ctcatcagct tcaaatctat tcgctactct agtcatccca
    23281 atttgtatta tcatcgcagc acttatttat aaattcgttc ttggagatgc aaataacttt
    23341 attgacaaca atgttgagaa cttacctaaa gttggtaact atgcaggtat ggcttacaaa
    23401 ggtggaccaa tcgttccaat cttaatgggt atgcttttaa tggtagtcgt attctcagta
    23461 gaacgtttca tcgttatcgg aaaagcaact ggtacatcta gtttagatgc ttttgtgaag
    23521 aaagtacaag cacttttaaa ttcaaataat atcgaagcag ctatggctga gtgcgataaa
    23581 caacaaggtt cggttgctaa cgtaatcaaa tctggtttga aaaaatatcg tgagatggaa
    23641 gttgaaacaa acatggacac agaccagaaa tgtttagcta tccaaaaaga tatcgaagaa
    23701 gctacaacat tagaaatgcc aatgttagag caaaacttaa cagtaatcgc aacattagta
    23761 tcagttggta cattaatggg attattagga acagtaacag gtatgatcaa ggccttcggt
    23821 ggtttaggtg cttctggagc tccggattca gcagcgttag caacaggtat ctctgaggca
    23881 cttatcaata ctgcaactgg tatcggtact tcaactttag cgattatcat gtacaacatc
    23941 ctgacttcta aaattgataa attaacttat gcaattgatg aagctggttt tagcatcatc
    24001 caaacttatg cttctacgca taaatagaaa ataatgtaat ttttttttac cggctttatg
    24061 gaaaaccgga agaattaaca tcattatata aaacataagt aatttttaaa attatgccta
    24121 gagcaaaggt tcaaagaaag agtacctcga ttgatatgac cgccatgtgc gacgtgtcct
    24181 tcctgttact tacttacttt attttatcag caactgcaaa acaaccggat cctttggatg
    24241 taagacttcc tacgtcaacg tataagatca aagttcctga aaaggatatc gcgattttaa
    24301 cgattggtaa agataaagtt tacttcgaag ctgctggtca ggatatcaaa gta
//
