LOCUS       NZ_CP014504            20543 bp    DNA     circular CON 03-MAR-2024
DEFINITION  Pedobacter cryoconitis strain PAMC 27485 chromosome, complete
            genome.
ACCESSION   NZ_CP014504
VERSION     NZ_CP014504.1
KEYWORDS    GSC:MIGS:2.1; RefSeq.
SOURCE      Pedobacter cryoconitis
  ORGANISM  Pedobacter cryoconitis
            Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
            Sphingobacteriaceae; Pedobacter.
REFERENCE   1  (bases 1 to 5950539)
  AUTHORS   Lee,J. and Kim,O.-S.
  TITLE     Complete genome sequence of Pedobacter cryoconitis PAMC 27485
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5950539)
  AUTHORS   Lee,J. and Kim,O.-S.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2016) Division of Life Sciences, Korea Polar
            Research Institute, 26, Songdomirae-ro, Yeonsu-gu, Incheon 21990,
            South Korea
COMMENT     ##MIGS-Data-START##
            alt_elev                          :: 1 m
            assembly                          :: SMRT Analysis v2.3.0
            collection_date                   :: 2014.01.03
            country                           :: Antarctica
            depth                             :: 5-10 cm
            environment                       :: soil
            investigation_type                :: bacteria_archaea
            isol_growth_condt :: 0.1x Tryptic soy agar, celsius degree 20
            lat_lon                           :: 62.236389 S 58.71772199999998 W
            project_name :: Genome sequencing of Pedobacter cryoconitis PAMC
            27485
            sequencing_meth                   :: PacBio RS II sequencing
            geo_loc_name                      :: King George Island
            env_biome                         :: ENVO:01000186
            env_feature                       :: ENVO:00000097
            env_material                      :: ENVO:00001998
            ploidy                            :: haploid
            num_replicons                     :: 1
            ref_biomaterial                   :: not applicable
            source_mat_id                     :: PAMC 27485
            biotic_relationship               :: free living
            trophic_level                     :: chemoheterotroph
            rel_to_oxygen                     :: aerobic
            assembly_name                     :: ASM118778v1
            finishing_strategy :: complete; 110x coverage; 1 contig
            annot_source                      :: prodigal v2.6.1
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Analysis v. 2.3.0
            Genome Coverage                   :: 110x
            Sequencing Technology :: PacBio RS II with P6-C4 chemistry
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 09:48:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,049
            CDSs (total)                      :: 4,958
            Genes (coding)                    :: 4,943
            CDSs (with protein)               :: 4,943
            Genes (RNA)                       :: 91
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 15
            CDSs (without protein)            :: 15
            Pseudo Genes (ambiguous residues) :: 0 of 15
            Pseudo Genes (frameshifted)       :: 3 of 15
            Pseudo Genes (incomplete)         :: 14 of 15
            Pseudo Genes (internal stop)      :: 2 of 15
            Pseudo Genes (multiple problems)  :: 3 of 15
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:50:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1744721
            Orig. end                         :: 1765264
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP014504.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20543
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="8"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20543
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20543
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10543](+)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10543
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     gene            complement(111..998)
                     /locus_tag="AY601_RS07445"
                     /old_locus_tag="AY601_1509"
     CDS             complement(111..998)
                     /EC_number="3.4.23.-"
                     /GO_function="GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025034.4"
                     /locus_tag="AY601_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1509"
                     /product="retropepsin-like aspartic protease"
                     /protein_id="WP_068398666.1"
                     /transl_table=11
                     /translation="MSYYLKSLLFLIFIALTSETLQAQTTVPITITNQGHVMVKAKING
                     VEGNFVFDTGAGLTLVTKKFAAKIKGLNKQDGGYTAFRATGEKLDADLYDATSLTIGSF
                     TETHPVLTIFDVDFGPIDGLISLMSFKKQVVTLDYANKQLIFETPKSFDALKTNGKTVA
                     LQLEISRDKSLDMFAYFNINDKLNLQFSIDSGSGNNVYRINSKYMPVLGIDSTDTVNVK
                     VTTKPSDFNPAVLTKIYTTNLQSIALKDLPSAKLENQKASFVEGLIYDGIVSLSWIGRK
                     ITIDVNHAQLIINE"
     gene            1122..1775
                     /locus_tag="AY601_RS07450"
                     /old_locus_tag="AY601_1510"
     CDS             1122..1775
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008245009.1"
                     /locus_tag="AY601_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1510"
                     /product="hypothetical protein"
                     /protein_id="WP_232324716.1"
                     /transl_table=11
                     /translation="MILLLTLCCFSSCFQIIEEINMANDGSGTVNLTVNLSASRAKVAS
                     IMLLDSVNGYKVPTKQTIQKEMDEIVAYLKKSKGISNVKKKVDFDNYIVSLSFAFEQVS
                     NINNINQSVLKKLKINAVNNSSYSYNLASSTFQRNYTHTKEAVIQYNKLKPAVKNVFKE
                     ATYTSIYRFEKPVVSSTNPLAKVSKSKKAILLNTGILGLINGKTNISNQIILSK"
     misc_feature    1777..1793
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.0"
                     /tool="antismash"
     gene            1798..3879
                     /locus_tag="AY601_RS07455"
                     /old_locus_tag="AY601_1511"
     CDS             1798..3879
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1511"
                     /product="hypothetical protein"
                     /protein_id="WP_068398671.1"
                     /transl_table=11
                     /translation="MNHFSKCAVTAIFSIVALGANAQNLVHKIPADAKAVVTLKGDNLI
                     ELMSVKEFNTTFLGKKMLGKMPESVKGQTKTIEDFGINLSSVFYYYNQSNDSVSYNCVL
                     APVKNSGQIDDLFKQSDKKFTVNAQLRSFYNHDSTEVVVWNDEMLLFVKSSGKESYFSR
                     PEVSKRLGLPDYSLITDTAATATDSVYVGNDYTTTADAAMTAAEPYPEAPVVRKKKTAV
                     RKHKKAAVRQHKSGHHSLPKHKTSKKYPKRKKIKKAISIDEQPFKDESYAIVDTANSDS
                     IMDENVPVSAYAQDIEIDTATINANKRIAAIKNKEVASWTKKMVSGFFLKDKRNSILSN
                     KDFVKSIDEKAEVTAWIANTEKAVLDFMPTAIFKGINVLNGYGSANVKLYLEKDAIRIG
                     SSITLSNEMAEAFIKINNRKVNKKFLNYVNEDKLTGYMAYALDTKAYLQEYPKLINRMY
                     GSIYKDEADMATDLFSLLLDEEAVSKVIKGDALFIFNGLKQNEVTYKTYEYNEDNFEKD
                     TVTKTKKETSPDFLLLVSTEDTRLLNKLIAYGVKKNVVKDQHSYYEISTLKTPMPLYFA
                     IHDGIIFVGTNVDEMKQIVNNQYQAKVSAKHRDAILKSNFSAYFSAKRLAGKIPANGVT
                     NPQQLIKTNTLLNSLGDIYLKSNQMKGNVFSGEISMDIPAKQENALKYLFSIAEDVEK"
     gene            3882..5147
                     /locus_tag="AY601_RS07460"
                     /old_locus_tag="AY601_1512"
     CDS             3882..5147
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1512"
                     /product="hypothetical protein"
                     /protein_id="WP_068398673.1"
                     /transl_table=11
                     /translation="MKKIFITATGIVLLLLLAVYGLLQYRQYSSYQNRIHQHAALIFKI
                     NVDHLVKKRGLGNLKSDSRGFGVPANIFVYTVSNKSALTFFCSLPVTDTVELKAYLKKV
                     FKMNHFIVDAQGSVWGNSQDQSIKIAYDDKNVVLCYSLLKENVNDIMGELLAGKSFLAD
                     TADQVVRLKKEDAPIVYDFKNYSGQASFADHRILLNGTFPVEDFGVTGTLNRPVALAKG
                     LSINAWVNGDLSRLFTKDIRFRDYVLERDSLLKYYKGYAAIEVGNPVNQSQSVISYTYN
                     DEFEKVEQVVQKKVKVPEITLSLKGNIASLVHYLQKKKVIASENQLNKELFPLYEVYGQ
                     YDNRMLQLSTNKGRPMRSAVVTTPYFLFAELDFDQIRKQNQFPVFNSYIKDLSSLKVKA
                     IKQNHQVGKVEIELKFTKEISF"
     gene            complement(5268..6536)
                     /locus_tag="AY601_RS07465"
                     /old_locus_tag="AY601_1513"
     CDS             complement(5268..6536)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015807903.1"
                     /locus_tag="AY601_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1513"
                     /product="putative sulfate exporter family transporter"
                     /protein_id="WP_068398676.1"
                     /transl_table=11
                     /translation="MTDKIKPLHEDWTVVILGSLVILFSLVFYIIPVPVYKWSSPAELG
                     TAIFNTGNLTTIFIQFIFVLIVGAIGAMFTGKPVRNFLISFPAVYLLTIFALIVAGNSF
                     IKSINLEAVIFSLAIGLIIGNLFKLPQWFKDTLSTELFVKIGLVLLGTTVIFSDILKAG
                     SLGLIQALIVVLSVWYFAFWLCKKLKVDDELTMMISSAVSICGVSAAIATSGAIKGDPK
                     KLSYVISMVLITAIPMMIFMPYIAAYFSFPQQVTGAWLGGSIDTTGAVVASGTLVGEEA
                     LKISTIVKFSQNVLLGIAAFAISIYWSYHKTAKGSDVVEKPTLKVIWERFPKFVLAFIG
                     ASVVFSFFLSPTTAAPVKDSLKNLQNAWFTLAFTSIGLETNFKDLFKNENKKPLYAFLL
                     AQLFNIFITLIIAWFLFSDATQL"
     gene            6877..7365
                     /locus_tag="AY601_RS07470"
                     /old_locus_tag="AY601_1514"
     CDS             6877..7365
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1514"
                     /product="hypothetical protein"
                     /protein_id="WP_068398679.1"
                     /transl_table=11
                     /translation="MKDLQTLKFYCLRYEVSAIEELIDSSDGIDNFVFSYYYPAADQAG
                     KPLQLVAYAHMVNSAYPDGIYSTYYDTLSIDDNKIEEICGPVILSNNILSLAQMLELID
                     YPEKPDYLILVPNVNSDRHIYYSVEAHYNNASVAGNTAQKTALFGPPPKNTNPSPPAT"
     misc_feature    7849..7864
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            8034..8825
                     /locus_tag="AY601_RS07480"
                     /old_locus_tag="AY601_1516"
     CDS             8034..8825
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="AY601_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1516"
                     /product="histidine kinase"
                     /protein_id="WP_068398685.1"
                     /transl_table=11
                     /translation="MTLVDIDIRLFLAVGIAAMLLLFISFLLIFIFTQRKKLQYQNSLQ
                     ALSEQQRNQLIEAAIKSEEAERHRIAEELHDEVGAILASSKLHFNSIKLGAGEYNQEIY
                     NKARELLEDGIKKVRNISHSLHSAILQEFGLNEAISHFALKITHESLIVVTVELDHVNH
                     YPMKNDISVYRIIQELLNNIITHAHATKIHLISEYTNQELNMRILHNGMGLTQQRFEEL
                     RFEKNGLGLKNIQNRAIFLRGELIFSQQDMGYQIDIHIPIN"
     gene            8833..9480
                     /locus_tag="AY601_RS07485"
                     /old_locus_tag="AY601_1517"
     CDS             8833..9480
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="AY601_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1517"
                     /product="response regulator transcription factor"
                     /protein_id="WP_068398688.1"
                     /transl_table=11
                     /translation="MSTIKIAIADDYAIFRDGLKVGLNQDKAMEVVLEAGNGTELLDGL
                     AQQKVDVILMDLRMPGMDGMEATKQIKKHYEHIRIIAVTLHDEDSFVIHLMEIGAHAYL
                     LKDANPVEIREAIYAVHLNGYYFNDLVNKALLKKIITKGNFKPTFKHKIELSERELEVL
                     QLICDEKTAIEIGTEIFLSPRSVEGIKQRLIDKIGVRNTAGLVLFAVKNGLI"
     gene            9628..9942
                     /locus_tag="AY601_RS07490"
                     /old_locus_tag="AY601_1518"
     CDS             9628..9942
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1518"
                     /product="hypothetical protein"
                     /protein_id="WP_068398691.1"
                     /transl_table=11
                     /translation="MAKLKLTHAELAALDALIAEMQGGHEGIEAEIGDVKAFITAVVKV
                     TAKATRVAVKATPYVTDIVEVATAILGKETHDEASKSLEQHAKAGINVQQLIELRKKFN
                     "
     gene            10001..10543
                     /locus_tag="AY601_RS07495"
                     /old_locus_tag="AY601_1519"
     CDS             10001..10543
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1519"
                     /product="hypothetical protein"
                     /protein_id="WP_068398693.1"
                     /sec_met_domain="cypI (E-value: 3.2e-28, bitscore: 97.0,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATDINIIYEAIVASFLAIWFLLTVLCQFRSTKFSNYIRHTIDIF
                     GLVPLWTFFAPNPGKSDYHLLYRDKIDEENNSEWEEMDITEERSLWSWCWNPDKRDKKI
                     LSDVIQSLISSIPHYKSANGYDLLMFSMPYLIVLHAVSNCECQNGTAHRQFMLAETSGY
                     LKENPPSVILLSVFHEI"
     gene            10553..11374
                     /locus_tag="AY601_RS07500"
                     /old_locus_tag="AY601_1520"
     CDS             10553..11374
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1520"
                     /product="hypothetical protein"
                     /protein_id="WP_068398696.1"
                     /transl_table=11
                     /translation="MISLIETNQLVLLILSIGLFISTMEYIKKIEIFSSKGLLSWNVMQ
                     LRWETKDQHSFFSPLFKLFNEKGLIVIFGLRCLIIFALLFFPLESIYGWILVGLLGGSL
                     LASSMITFYGSDGSDQMNMLIIITLFLCHFPLGTGSRLETIGLWFIALQTCLSYTVAGI
                     AKLASAEWRASTAIKDVFSTKTYGSQWAALLMKKYPGLNVFLCWNVMIMETLFPLCLIL
                     PFNYALIFIIWGFLFHLFTAIIMGLNSFFWAFMAAYPALFFVNHQIQSYLY"
     gene            11388..11807
                     /locus_tag="AY601_RS07505"
                     /old_locus_tag="AY601_1521"
     CDS             11388..11807
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016056.4"
                     /locus_tag="AY601_RS07505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1521"
                     /product="DCC1-like thiol-disulfide oxidoreductase family
                     protein"
                     /protein_id="WP_068398699.1"
                     /transl_table=11
                     /translation="MLSALNGKKDIILFDGICNFCNSYINYVISHDQHNRFVFASLQSE
                     VAKELSAIHHIDLQDLNSIVVIHNKRIFTRSDGIIHIAKHLKSRWSWLLLCVEFIPRSI
                     RNYGYTLFANRRYSWFGQMNSCVVPTQEMREKFLT"
     gene            complement(11832..12509)
                     /locus_tag="AY601_RS07510"
                     /old_locus_tag="AY601_1522"
     CDS             complement(11832..12509)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1279: pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015808174.1"
                     /locus_tag="AY601_RS07510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1522"
                     /product="pseudouridine synthase"
                     /protein_id="WP_068398703.1"
                     /transl_table=11
                     /translation="MLEIVYQDDHIIAINKPHGLLVHRSSIATDAKEFALQLLRDQVNR
                     RVSPVHRLDRKTGGLLLFAFEKDVEIALHQQFQNGEIQKKYLAIVRGYAPDSQDIDYPL
                     VKENGAIQEAFTSFITLKRAELDIALGQHPTSRYSLVEATPTTGRMHQLRKHFAHIFYP
                     IIGDRKHGCNKQNRFFKEQWEMTTMLLHASELSFKHPVTKEDIHLKATVQEEFKRVMDI
                     MSW"
     gene            complement(12535..13146)
                     /locus_tag="AY601_RS07515"
                     /old_locus_tag="AY601_1523"
     CDS             complement(12535..13146)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1523"
                     /product="zeta toxin family protein"
                     /protein_id="WP_068398706.1"
                     /transl_table=11
                     /translation="MIQPELIFVSGCNASGKSTFIRTRLNELEGFEILMTDVYKERTKE
                     LATAAIAQRKNIVIETVFNDRSFKDLVDHARNSGYHTSLIVLFLDNFEQSMKRVTLRIV
                     QQNGMNISGSNIRINFNESFKNIATYFLYFDRSEFIYTEIGEVNQSIMSFENGELVSYY
                     SSGLNYPQKFAAYSFQKDRLSKEVFDMITANQNFHLPENL"
     gene            complement(13146..13388)
                     /locus_tag="AY601_RS07520"
                     /old_locus_tag="AY601_1524"
     CDS             complement(13146..13388)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AY601_RS07520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AY601_1524"
                     /product="hypothetical protein"
                     /protein_id="WP_068398709.1"
                     /transl_table=11
                     /translation="MKKVSIVDRLLKNMGNMHELGKQRAFELGNPFYARFKEDGEYWRK
                     EMPNGDKYLVEVEVIIDEFDMPVQIKDTMIKKLDR"
     gene            13467..14204
                     /locus_tag="AY601_RS07525"
                     /old_locus_tag="AY601_1525"
     CDS             13467..14204
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008242001.1"
                     /locus_tag="AY601_RS07525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1525"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_068398711.1"
                     /transl_table=11
                     /translation="MKLDQGIIKKSKWMWENCLPHISVDSVVFGFHENQLKVLLLKMNV
                     AKKWLLPGGYILKNESLQDAAKRVLFERTGAERVYLQEFGVFGAINRSEGFFDGYEDDL
                     WYKQRFISAGFYALVDYTEVNVSADEYSETCEWRSIDDLPELAMDHQLIYTNALTLLRQ
                     QLSYKPIGLNLLPEKFTLPELQKLYETILGKPLNRGNFYRRMMRFDILIKQEDLRKGGA
                     HKAPYLYSFDPLKYHESLQGLDW"
     gene            complement(14208..15614)
                     /locus_tag="AY601_RS07530"
                     /old_locus_tag="AY601_1526"
     CDS             complement(14208..15614)
                     /GO_component="GO:0009279 - cell outer membrane [Evidence
                     IEA]"
                     /GO_function="GO:0015288 - porin activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1076: RND efflux
                     system, outer membrane lipoprotein,"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016197047.1"
                     /locus_tag="AY601_RS07530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1526"
                     /product="efflux transporter outer membrane subunit"
                     /protein_id="WP_068398714.1"
                     /transl_table=11
                     /translation="MTHKYNKQVFALLVAATFFSACSVTKTYDTPQVKTDGLYRGQNVT
                     DSATMASQPWQTLFTDEKLKVLIQKGLDQNVNLKNAIQNILQAQASLQQAKLAFLPTLS
                     ADANATRSKQSSAGLNFPPGININTLTNTYKLSMSTSWEADIWGKLSSSKRAALAKYLE
                     TDAAKKAVQTQLIADIANNYYGLLALDQQLAITQKTLESRIANVETMKALKEGAVVNGA
                     AVVQSEASRYATEVSIPDLKRSIRETENAISILLAENPGSIDRSTMEAQAVPSALATGV
                     PAQLLQNRPDVQQAELAFRGAFENTNLARTYFYPSLTLTASAGFSNLTLKDFFDHSVFY
                     NLVGGLTQPIFNQGLNKARLKTAQSLQIQALNNFQQSLLVAGQEVSNALYAYQTAVEKE
                     DSRIKQVAALVKAVDYTQDLLRFSSATNYTDVLTSEQSLLAAQLSGVSDHLQKMQAVVN
                     LYRALGGGWK"
     gene            complement(15643..18843)
                     /locus_tag="AY601_RS07535"
                     /old_locus_tag="AY601_1527"
     CDS             complement(15643..18843)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) RND_efflux"
                     /gene_functions="transport (smcogs) SMCOG1049:
                     AcrB/AcrD/AcrF family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010599629.1"
                     /locus_tag="AY601_RS07535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1527"
                     /product="efflux RND transporter permease subunit"
                     /protein_id="WP_068398717.1"
                     /transl_table=11
                     /translation="MFKIFIQRPVLSTVISVIIVILGILGLTSLPIAQYPDIAPPTVNV
                     SANYSGANADVVLKSIVIPLEEQINGVENMTYMTSTATNDGAASIKIYFKVGTDPDLAA
                     VNVQNRVSRATSLLPAEVTQAGVTVTKSQSSNLLIFALYSDDKTYDQTFLQNYAKINLV
                     PQIQRVTGVGDATVFGSKDYSMRIWLKPDMMQQYSLIPSDISAALAEQNIEAAPGKFGE
                     NGNQAFQYVIKYKGRLTTPTEFENIIIKSAGNGQLLRLKDVAKVELGALSYTATIETNG
                     KESVGVAISQTPGSNARDVINNSKKIIEEAAKTFPKGVKYTTLVDVNENLDASIDKVIH
                     TLVEAFILVFIVVFIFLQDLRSTLVPAIAVPVAIIGTFFFLNLFGFTINLLTLFALVLA
                     IGIVVDDAIVVVEAVHAKLDNGYKSAKKATIDAMSEISGAIISITLVMAAVFIPVTFIT
                     GSTGVFYKQFGITLAVAIILSAINALTLSPALCALLLKPHADDHKHQSFVQRFYTAFNV
                     AFDNLTNKYKRSVQFLSVKKWIVLGSIAIAGAALFYMMKTTPSAFVPAEDQGTIFANIS
                     LPPSSSMERSTAIAKQVDSIAHTIPGVQNTLRIVGQNFTAGAGSAYSMVILKLKTWDDR
                     KLSVDQVIGQLFAKTSGIREASIFFISPPTIQGFGQSGGFEFQLQDKGGHTTDEFFKVN
                     NTFLAALSKRPEIQYATTPFNPGFPQYLMDVNLEKCKDAGVTVNTVLQTMQGYYGGLYA
                     SNFNKFGKQYRVMVQAAAEFRANPEGLNKIFVRNSAGNMAPITEFVKMTRVYGPESISR
                     FNLFSSISITGAPNAGFSSGDAIKAIQEVAASTLPAGYGFDFSGLTREELASGSETVFI
                     FVLCLIFVYFLLSAQYESYILPFAVLLSIPFGLAGAYLFSIIFKLNSNIYLQISLIMLI
                     GLLAKNGILIVEFALDRRRNGMPIVQAAVEGAVARLRPILMTSFAFIFGLVPLMFSTGA
                     GAVGNKSIGTGAVGGMLIGTILGVFVIPVLFIIFQSLQEKISGPARKSYDDDEEEEEQE
                     TKGIEGAEEHKLLEPPTA"
     gene            complement(18850..20013)
                     /locus_tag="AY601_RS07540"
                     /old_locus_tag="AY601_1528"
     CDS             complement(18850..20013)
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016197044.1"
                     /locus_tag="AY601_RS07540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AY601_1528"
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="WP_068398720.1"
                     /transl_table=11
                     /translation="MKTSIQIGLLFLTGLTLASCGNDKNKAAQAAAAAGQVKEYKVLKL
                     EPRSATLNTDYPASIQGQQNIEIRPRVDGYIDKIFVDEGAVVKIGQPLFKISAPQYEQE
                     VRTANASIANAMAQLNAAKLAINKVKPLVEKDIVSKYELESAQYTYESAQAAVATAKAS
                     LVNAKTNLGFTTVTSPVNGVVGSIPFRLGSLVSSTTADPLTTVSSIGNVYAYFALNEKL
                     LLDFTKDGSGSFAQKLAKLPKVSLLLSDGSPYTEEGRIETVNGLINTATGSANIRARFP
                     NPKGIIRSGSSATVRIPNAVKDAILVPQSATFELQDKRFVVVVGQDGKTKNVAVTVMEN
                     TAGNFFVVESGLKAGDQIVLEGVATLKDGTQIKANAENPETVYADLK"
ORIGIN
        1 ggttgttacc tgattttagg taaagtagtg gaagactttg gttatccgag tgtagaagtg
       61 atcaaatttg ccaagttacc gattgtcggt aatcctgtat tggaataata ctattcattg
      121 ataatcagct gtgcatgatt tacatcaatt gtgatctttc ttccgatcca gctaagtgaa
      181 acgataccat cataaatcag cccttccaca aaagaagctt tttggttttc cagttttgct
      241 gaaggaaggt ctttaagggc tatggattgc aggttagttg tgtaaatttt ggttaataca
      301 gcagggttaa aatcacttgg tttagtggtc actttcacgt ttacagtatc tgtactgtcg
      361 attcccagca caggcatata tttagagttg atgcggtaaa cgttatttcc tgaaccacta
      421 tctatagaaa attgcaggtt tagtttatcg ttgatattaa aataagcaaa catatccaat
      481 gatttatctc tggatatttc cagttgtaag gcaaccgttt tgccgttggt cttcagcgca
      541 tcaaagcttt ttggcgtttc aaaaatcagt tgtttattgg cataatccag ggtcactact
      601 tgctttttga agctcattaa agaaatcagt ccgtctatcg ggccaaagtc cacatcgaaa
      661 attgtcagca ccggatgtgt ttcagtaaaa cttcctatag tcaaagaagt ggcatcataa
      721 agatcggcat ccagcttttc tccggtcgct ctgaaggccg tgtaacctcc atcctgcttg
      781 tttaatcctt tgattttagc tgcgaatttt ttggtgacca gcgttaagcc agcaccggta
      841 tcgaatacaa aattgccttc aacaccatta atttttgctt tgaccatcac gtgtccctgg
      901 ttggttatgg taatcggaac agtggtctgt gcttgtaatg tctcgctggt taatgcgata
      961 aaaatcagga ataataagga ttttagatag taggacattg attctggcat gaaaaatgga
     1021 aagtggaaga tacaaaaaga ggattaaaaa aactctacct ttaaaaaata ttatataacg
     1081 atcattctac cttttaaatg caaaataaag cgctcagata cttgatatta cttttaacgc
     1141 tatgttgttt ttcttcttgt tttcaaatca ttgaagagat taatatggct aatgatggct
     1201 caggaacagt gaacctaacg gttaatctaa gtgcgagcag agctaaagta gcctctatta
     1261 tgcttttaga cagtgtcaat gggtataaag taccgaccaa acaaactatt cagaaagaaa
     1321 tggacgaaat agttgcctat ttgaaaaaat ccaaagggat tagtaacgtt aaaaagaaag
     1381 tagatttcga taattatatc gtgagcttaa gcttcgcttt tgaacaggtt tctaatatta
     1441 acaacatcaa ccagagcgtt cttaaaaagt taaagattaa tgctgtaaac aattcttcgt
     1501 acagttataa tctagcatcg agcacttttc aacgcaatta tacccatact aaagaagcag
     1561 ttatacaata taacaagctg aagccagcag tgaaaaatgt gtttaaagaa gcgacttata
     1621 ccagcattta caggtttgaa aaaccggtgg tcagttccac taatccgcta gctaaagtct
     1681 ctaaatctaa aaaagcaatt ttgctgaata cgggcattct gggcctgatt aacggtaaaa
     1741 ccaatatctc taatcaaatt atcctgtcta aataatattt tataatatat cattctcatg
     1801 aatcattttt ctaaatgtgc cgttactgct attttttcta tagttgcgct gggtgcaaat
     1861 gcacaaaacc tggtccataa aatcccggca gatgccaaag ctgtggttac ccttaaaggg
     1921 gacaacctga tcgaactgat gtccgtaaaa gagttcaata ctacttttct gggcaaaaaa
     1981 atgctgggaa aaatgcctga atctgtgaaa ggccagacta aaactatcga agattttggg
     2041 attaacctgt cttcggtttt ttattattat aaccagagta atgatagtgt aagttataac
     2101 tgtgtccttg cccctgttaa aaattcagga cagatagacg atttattcaa acagtctgac
     2161 aagaaattca cggtaaatgc tcaattgaga tctttttata accatgattc tacagaagtg
     2221 gtggtatgga atgatgaaat gctactcttt gtaaagagca gcggaaaaga gtcttatttt
     2281 tccagaccag aagtgagcaa aagattaggt ttaccagatt atagtttaat aacagatact
     2341 gcggctactg cgactgattc tgtctatgtc gggaatgatt atacaacaac tgcagatgct
     2401 gcgatgacag ccgcagaacc gtatccggaa gcgccagtgg tcaggaaaaa gaaaactgct
     2461 gttcgcaaac ataagaaagc tgctgttcgt caacataaat ccgggcacca tagtcttcca
     2521 aagcataaaa cgtcaaagaa atatccgaaa agaaaaaaga taaagaaagc gatcagtatt
     2581 gatgagcaac cttttaagga tgagagttat gcaatagttg acaccgctaa ttcggatagt
     2641 attatggatg aaaatgttcc ggtttctgct tatgcacagg atatcgaaat tgataccgct
     2701 acaataaatg caaataaacg gatcgcagcc attaagaata aagaagtagc cagctggaca
     2761 aaaaagatgg tatctggttt ctttttgaag gataaacgta attctatctt aagcaataaa
     2821 gattttgtta aaagtataga tgaaaaagca gaagttaccg catggattgc gaatactgaa
     2881 aaagcggtac tggattttat gccaacagca atttttaaag gaatcaatgt gctgaacggt
     2941 tatggaagcg cgaatgtgaa actttacctg gaaaaggatg ccatcagaat tggttcatcg
     3001 attactttaa gtaacgaaat ggcagaagcc tttatcaaaa tcaataacag aaaggtaaac
     3061 aagaagtttc tgaactatgt gaacgaggat aaacttaccg gttatatggc ttatgcgttg
     3121 gatactaagg cttatttgca ggaatatcct aagttaatca acagaatgta cggttcaatc
     3181 tataaggatg aagctgatat ggcgaccgat ttattttcac tgttactgga tgaggaagcg
     3241 gttagtaaag taattaaggg tgatgcgctg ttcattttca atggcttaaa gcaaaatgag
     3301 gttacttata aaacttatga gtacaatgaa gataattttg agaaagacac ggtcaccaaa
     3361 actaaaaaag aaacttctcc tgatttcctg ctcctggttt ctacggagga taccaggtta
     3421 ttaaataaat tgattgctta tggagttaag aaaaatgtag ttaaggatca gcatagttat
     3481 tatgagatct ctacactaaa aacacccatg cctctttatt ttgcaattca tgatgggatt
     3541 atctttgtcg gaacaaacgt agatgagatg aaacagattg ttaataatca ataccaggct
     3601 aaggtttctg ctaaacatag ggatgcaatt ctgaaaagta acttctctgc ttatttcagt
     3661 gctaaaaggc tggctggaaa gattcctgcc aatggagtga ccaatcctca acagttgatc
     3721 aaaacgaaca cactcctaaa ctctttagga gatatttatc tgaaatctaa ccagatgaag
     3781 ggaaatgtgt tttctggtga aattagcatg gatatcccgg caaagcagga aaatgcgcta
     3841 aaatatttat tctctattgc tgaagatgta gaaaaataag gatgaagaag atatttataa
     3901 cagcaacagg tatagtttta ctgttgctgt tagctgttta cggcttactt caatatagac
     3961 agtacagttc ttatcagaac aggattcatc agcatgctgc gctgattttt aaaatcaatg
     4021 tagatcatct ggtgaaaaag agaggtttgg gcaacttaaa aagtgactct cgtggatttg
     4081 gtgtacctgc taatatcttt gtttatacag ttagcaataa atcagcattg acatttttct
     4141 gttctctccc ggtaaccgat accgtcgaat taaaggctta tcttaaaaaa gtatttaaga
     4201 tgaatcattt tatagtggat gcgcagggat cagtctgggg aaatagccag gatcaaagta
     4261 taaaaatagc ttatgatgac aagaacgtag tgctgtgtta ttctttatta aaggaaaatg
     4321 taaatgatat tatgggagaa ctgctggcgg ggaaaagctt tttagcagat accgctgatc
     4381 aggttgtcag gctgaaaaag gaggacgctc ctattgttta tgatttcaaa aattactccg
     4441 gacaggcaag ctttgctgat caccgtattt tattaaatgg gacatttcct gtggaggact
     4501 ttggagtaac aggtactttg aaccgtccag ttgctttagc taaaggatta agtattaatg
     4561 cgtgggtaaa tggggattta agcaggttat tcactaagga tatcaggttc agagattatg
     4621 tactggaaag ggattccctg ttaaagtact acaaaggata cgcggctatt gaagttggaa
     4681 atcctgtaaa ccagtctcaa tctgtaatca gctatactta caatgatgaa tttgagaagg
     4741 ttgaacaggt ggttcagaaa aaggttaagg ttccggaaat tactttatcc ttaaaaggaa
     4801 atatagcatc attggttcat tacttgcaaa agaaaaaggt tattgcatct gaaaatcagc
     4861 tgaataaaga attgtttcct ttgtatgaag tgtatggtca gtatgataac cggatgttac
     4921 aattgagtac gaataaaggc aggccaatgc gttctgcagt tgtaactact ccttattttc
     4981 tctttgcgga actggatttt gatcaaatca gaaagcagaa ccaatttcct gtgtttaata
     5041 gctatatcaa agatctgagt tcgttgaagg tgaaggcgat caaacaaaat catcaggtcg
     5101 gaaaagttga aattgaactg aagtttacga aagagatcag tttttagcaa cagtaattct
     5161 cctttcaaaa gcttaaggtg tgtcttaatt atttaaagtt tcgctgcatc ttatccttta
     5221 aatcctggct gcatcttatt gtttaaacct tggttgcatc ttattcttta aagctgcgtt
     5281 gcatcactaa aaaggaacca ggcaataatt aaggtgatga aaatgttaaa cagttgtgct
     5341 aataaaaatg cgtacaatgg cttcttattc tcattcttaa aaagatcttt aaagttagtt
     5401 tccagaccga tactggtgaa agcaagtgta aaccatgcat tttgaaggtt tttaaggcta
     5461 tcctttaccg gagctgctgt agttggcgat aaaaagaagg agaaaactac tgaagcacct
     5521 ataaaagcga gtacaaattt aggaaaccgc tcccagatta cttttaaagt aggtttttct
     5581 acgacatcgc tgcccttcgc agttttatga taagaccagt aaatgctgat ggcaaaagct
     5641 gcaattccga gcagcacatt ctgtgaaaat ttaacaatgg tactgatttt taacgcttcc
     5701 tctcctacta aagtccctga agcgactacc gctcccgtcg tatcaatact accacccagc
     5761 catgcaccgg ttacttgttg cgggaaagag aaataagccg cgatataagg catgaaaatc
     5821 atcataggga ttgcagtgat gagcaccata gaaatcacgt aagaaagttt tttaggatca
     5881 cctttaatgg ctcctgaagt agcaatcgca gcagaaacgc cgcaaataga gactgcactg
     5941 gagatcatca tggtcaattc atcatctact ttcagttttt tacaaagcca aaatgcaaag
     6001 taccatacag agagcactac aattaatgcc tgtattagtc ctagtgagcc tgctttaagg
     6061 atatctgaga agataactgt ggttcctagt aaaacaagcc cgattttaac aaaaagctct
     6121 gtagacagcg tgtctttgaa ccattgggga agtttaaaaa ggttaccgat aatcaggccg
     6181 atggccagac taaagatcac cgcttcgagg ttaattgatt tgataaatga attaccggct
     6241 acaatgaggg caaaaatggt gagcaggtat actgccggaa aactgattag aaaattcctg
     6301 actggtttgc cggtgaacat tgcgccaatt gcaccaacta tcagtacaaa aataaactga
     6361 atgaagattg tcgttaggtt acctgtatta aaaatggccg ttccaagttc agcaggacta
     6421 ctccatttat agactggtac tggtattata taaaaaacaa gggaaaagag aataacaaga
     6481 gatcccagga taactactgt ccaatcttca tggagaggtt tgattttatc agtcattggt
     6541 cacaattaag gtcaagctta cagttggtta agcactctaa tatattaaaa tttaatacat
     6601 aagaagtgta agactacttg atattcaaac tccaatccgt tagtggatat ttattttgac
     6661 tttattattt ataattttta ttgcccccta agtgtgagct ggcaaacctg caaagtagct
     6721 attgctaatc cgataaaggc acttaaatat ggctggaagc aggtttaaat aatcaaaccg
     6781 taaaactact tcaattaaaa attgcgtatt tctacgttgt gagttctata tttttctact
     6841 ctatatttgg atcatcaaac cccaaatatt cgaaagatga aagatctaca aacgctcaaa
     6901 ttttattgtt taaggtatga agttagtgct attgaagagt taattgacag ctctgatgga
     6961 atagataact ttgtattttc ttactattat ccggcagctg atcaggcagg taaaccgctg
     7021 caattagtag cttatgcgca catggtgaat tctgcttatc ctgatggtat ttatagtact
     7081 tattatgata ccttatcaat tgatgacaac aaaatcgagg aaatctgcgg tcctgtaata
     7141 ctgagtaata atatcctctc actagctcaa atgctggaat taattgatta tcctgaaaaa
     7201 cctgattatt taatccttgt tccgaatgta aattcagaca gacatatata ttacagcgta
     7261 gaagcgcatt acaataatgc ttcagttgct ggcaatactg cacagaaaac ggctttattt
     7321 ggtcccccac ctaaaaatac gaatccatcc cctcctgcta cttaaaatca ggaaaatgct
     7381 acattatata ttacatatac tacaagttat cctggattgg tcagaagttt gggcattatt
     7441 gattccagct gccatttcag tctatagaaa acaaccggtc attcatcgac cggttgtttt
     7501 ttatatatgg attgcactgc tcatcaatag ctgtatagat attgtctgga agtttagaac
     7561 cctgcttccc ctgagcttca gttcaaacaa ttggctgtat aatttacact cagtggtaac
     7621 gttcttttta ttcagttcat tttttattgg ccttgaacaa ccatttttag taagaataaa
     7681 aaaaatagtt ctaattgcct ttatcgtttt tctagtaatc aattttatgt tttatgaaaa
     7741 cttttttgat tactggagat tgagtagcag attattgtca gttgaggcaa ttttattgtt
     7801 gttttactca ctcagctatt ttttatttaa ggttcacgaa aacgttaatg tgaatatatt
     7861 cacgagtgac ttctggatcg caaccggact tggtttgtat gtagctgtta atttttttat
     7921 ttttctttta tacaatgaac taactgtgca catgataaat tttgcgatca atttatggaa
     7981 tgtccataat atctcttaca tcttttttaa cttctttatt gctaaaggtt tttatgactc
     8041 tggtagacat tgatatcaga ctttttcttg cagtgggtat tgcagcaatg ctattgttgt
     8101 ttattagctt tttgttgatt tttatattta cgcaacgcaa gaaattacag tatcagaatt
     8161 ctcttcaggc tttaagtgag cagcagagga atcaactgat agaagcggct atcaaaagcg
     8221 aagaagccga aaggcatcgt atagccgaag aattgcatga tgaagtaggt gcaattctcg
     8281 cctcttcaaa gttacatttc aatagtatca aattaggtgc aggagaatac aatcaggaga
     8341 tctacaataa agccagagaa ttacttgaag atggaattaa aaaagtaaga aatatatcac
     8401 atagccttca ttctgcaatt ctgcaggagt tcggtttaaa tgaagccatt agtcattttg
     8461 ccttaaaaat cacacatgaa tccctgattg tggttaccgt tgagcttgat catgtcaatc
     8521 attacccgat gaaaaatgat atcagcgttt accgtatcat tcaggaattg ctcaataata
     8581 ttattaccca tgcacatgcg actaaaatcc atctcatttc tgagtatacg aaccaggaat
     8641 taaacatgag aattttacac aatggtatgg gcctgactca acagcgtttt gaagaactaa
     8701 ggtttgaaaa aaatggactg ggtcttaaga acatacaaaa cagagccatt ttcctccgtg
     8761 gagaacttat attttctcaa caggatatgg gttatcaaat tgatattcac attccaatta
     8821 actagataat acatgagcac aataaaaata gcaatcgcag atgattatgc catattcagg
     8881 gatggtctaa aagtaggttt aaatcaggat aaggctatgg aggtagttct ggaagccgga
     8941 aatggtactg agctgcttga tgggttagcg cagcagaagg tagatgtcat tttgatggat
     9001 ttaaggatgc cggggatgga tggtatggaa gctactaaac aaatcaaaaa acactatgag
     9061 catatcagga tcattgcggt caccttacat gatgaggata gttttgtaat ccatctgatg
     9121 gagattggtg cacatgctta tttattaaag gatgctaatc ctgtcgaaat cagggaggca
     9181 atttatgcgg tacatttaaa tggttattat tttaatgacc tggtgaacaa ggcattgttg
     9241 aaaaagatca ttaccaaggg gaatttcaaa ccaaccttta agcataagat tgaattatcg
     9301 gagcgcgaac tggaagtcct gcaattaatt tgtgatgaga agacggctat cgagattggt
     9361 acggaaatct ttttaagtcc tcggtctgta gaggggatca aacaacgcct gattgataag
     9421 attggtgtcc gcaatactgc aggcctggtt ttgtttgctg taaaaaacgg gctgatttaa
     9481 ccctccggct aagtagaatt acttgttatt ttctttgcgt agatctacta tggctatttt
     9541 cctgtgatct tccgtccttt atattgtgca atgaagcttc aaattaacgc acctaaaaaa
     9601 aactatttta tttaaaaaga ttaaattatg gcaaagttaa aattaactca cgcagaatta
     9661 gctgcacttg atgcccttat tgcagagatg caaggtggcc acgaagggat cgaagcggaa
     9721 atcggagatg ttaaagcatt cattaccgca gttgtaaaag taaccgctaa ggctaccaga
     9781 gttgcagtaa aagcaactcc ttatgtgact gacatcgtag aagtagcaac tgctatttta
     9841 ggtaaagaaa ctcatgatga agcaagcaaa tcattagaac aacatgctaa agctggtatc
     9901 aatgttcagc aactaataga acttcgtaaa aagtttaatt aattactgtt ttaagggcgg
     9961 gcgtgattgc acccgccttt aaaatctaat cctcttcaat atggccacag atatcaatat
    10021 tatttatgaa gctatagtcg caagttttct tgccatatgg tttttgctca ccgttttatg
    10081 ccagttcaga agtactaaat tttctaatta tatcaggcac acgattgata ttttcggttt
    10141 ggttccctta tggacattct ttgcacctaa tcctggaaaa agtgattatc atttattata
    10201 cagagataaa attgatgaag agaataacag tgaatgggaa gaaatggata tcactgaaga
    10261 gcgttctttg tggtcctggt gctggaatcc agataaaagg gataaaaaaa tattatcaga
    10321 tgtaattcaa agtttgattt ctagtattcc tcattataaa agcgctaatg gatatgattt
    10381 actcatgttt tccatgccat atttaattgt attgcatgcg gtaagtaatt gtgaatgtca
    10441 aaatgggact gcccacagac agtttatgct tgccgaaacc tcaggatatt tgaaagagaa
    10501 ccccccttct gttatcttat tatctgtatt tcacgaaata taaatttgaa ttatgatatc
    10561 acttatagaa accaatcagc ttgttctgct cattttaagt attggattgt ttatttccac
    10621 tatggagtat attaaaaaaa ttgaaatctt ctcttctaaa ggtttactat cctggaatgt
    10681 aatgcagttg cgttgggaga cgaaagatca acactcgttc tttagcccgc tgttcaagtt
    10741 gtttaatgag aaagggctaa ttgttatttt tgggttgaga tgcctgatta tttttgcact
    10801 gctatttttt cctctggaaa gtatctatgg atggatttta gttgggttac taggtggcag
    10861 tctgttagca agttccatga tcacgtttta tggaagtgat ggttcggatc agatgaatat
    10921 gctgattatt atcacgcttt ttctttgtca tttccctttg gggactggtt cccgtttaga
    10981 aacaataggg ctttggttta tagcgttaca aacttgtctt tcttatacgg tagcaggtat
    11041 tgctaagctt gcttctgcag agtggcgtgc ttctacggcg attaaggatg tcttttctac
    11101 taaaacttat ggttcacaat gggctgcgct attgatgaaa aaatatccgg ggctcaatgt
    11161 ctttttgtgc tggaatgtga tgattatgga aaccttattt ccgctatgct tgattttacc
    11221 ttttaattat gcactgattt ttatcatctg gggtttcctg tttcatttat ttacagcgat
    11281 cattatgggt ttaaattcat tcttctgggc ttttatggct gcatatcccg cattgttttt
    11341 tgtcaatcat cagattcaat cttatttgta ttaatcagaa aatagcaatg ttatcagctt
    11401 taaacggaaa aaaagacatt atactatttg atggaatttg taatttctgt aatagttata
    11461 tcaattacgt cattagccat gatcagcata accggttcgt ttttgcttct ttgcaaagtg
    11521 aggtcgcaaa agagttatcg gccatccacc atatcgactt gcaggatctg aatagtatag
    11581 tggtcattca caataaaagg atctttaccc gttctgatgg gattattcac attgccaaac
    11641 acttaaaaag caggtggtca tggttgttgt tgtgcgttga gtttattccg cgttctatcc
    11701 ggaattatgg ttatacttta ttcgccaatc gccggtattc atggtttggg cagatgaata
    11761 gctgtgtagt tccgacccag gaaatgagag agaagttcct gacctgagcc tgaatggtcg
    11821 tgttttaata cttaccagct catgatatcc atcactcttt taaattcttc ttgtacagtg
    11881 gctttcaaat ggatatcttc tttggtgact gggtgtttga agctaagttc tgaggcatgt
    11941 aatagcattg tcgtcatttc ccactgttct ttaaagaatc tgttttgttt gttacaccca
    12001 tgtttccggt cacctataat tgggtaaaag atatgtgcaa agtgtttacg gagctggtgc
    12061 atacgtccgg ttgtaggggt tgcttctact aaagagtatc ttgaagtagg gtgctgaccc
    12121 aaagcaatat cgagttctgc tctttttaag gtaataaacg aagtaaaagc ttcttgaatt
    12181 gcaccatttt cttttactaa tgggtaatct atatcctggc tgtcaggagc atagcctcta
    12241 acaattgcaa ggtatttctt ttgtatttct ccattttgaa actgctgatg caatgcaatt
    12301 tcaacatctt tctcgaaagc aaatagtaat aaaccacctg tttttctgtc taaacgatgt
    12361 acaggactta cgcgtctgtt cacttgatct cttaagagct gcaaggcaaa ttctttcgca
    12421 tcggttgcaa tggaggaacg atgtacaagt agtccgtgtg gtttattgat cgcaatgata
    12481 tgatcatcct ggtatacgat ttcaagcatt aatttttttc gcgaatatag ctttttataa
    12541 attctccggg agatgaaagt tctgatttgc tgtaatcata tcgaatactt ctttgctcag
    12601 acggtctttt tggaagctat aggcagcaaa tttttgggga taatttagtc cggaagaata
    12661 ataactaaca agttcaccat tttcaaaaga catgattgat tgatttacct ctcctatttc
    12721 tgtatatata aattccgaac ggtcgaaata taaaaaatac gtagctatgt ttttaaaact
    12781 ctcattgaag ttaattctga tattgcttcc tgatatattc atgccatttt gttgtacgat
    12841 acgaagagtg acccttttca tggattgttc aaagttgtcc agaaacaaaa caattaaaga
    12901 agtatggtat ccagaatttc gggcatgatc aactaaatcc ttaaatgatc tgtcattaaa
    12961 tacagtttca attacaatgt tctttcgctg tgcaattgct gctgtggcga gctctttcgt
    13021 cctttcttta taaacatcgg tcattaagat ttcaaaccct tctaattcat taagacgggt
    13081 acgaataaaa gtagattttc ctgaggcatt acatccggaa acaaagatca gttcaggttg
    13141 aatcattagc gatcaagttt tttaatcata gtatctttta tttgtaccgg catatcaaac
    13201 tcatcaatta tgacttctac ttctacaaga tacttatcac catttggcat ctctttgcgc
    13261 cagtattcac catcttcttt gaatcgggca taaaacggat ttcctaattc aaaagcacgc
    13321 tgcttaccca attcatgcat gttacccatg ttctttaata gacggtcaac tattgaaact
    13381 tttttcatat ggatccgagg taaaacttag ccaaatatac aaaaaagcca aaatatcttt
    13441 taaacagatt cttatattgc cccatcatga aattagatca gggcatcatc aagaaaagta
    13501 agtggatgtg ggaaaattgt ttgcctcata tctctgtaga cagcgtagta ttcgggtttc
    13561 atgaaaacca gcttaaagta ttattactca aaatgaatgt tgccaagaaa tggttattac
    13621 caggtggtta tattcttaaa aatgaaagct tacaagatgc agcgaaacgt gttttgtttg
    13681 aacgtacagg tgcggaacgt gtctatttac aagaatttgg tgtatttggg gcaataaacc
    13741 gttctgaagg attctttgat ggctacgagg atgatttgtg gtacaaacaa cgttttatct
    13801 ctgccgggtt ctacgcactg gtagattaca ccgaagtaaa tgtgagcgca gatgaatata
    13861 gtgagacttg tgagtggaga agtattgatg atttgccgga attggcaatg gaccatcagt
    13921 tgatctatac gaatgcttta actctattaa gacaacaatt aagttataaa ccgattggac
    13981 tgaatttact tccggagaag tttacactgc cagagttgca aaagctttat gaaactatat
    14041 tggggaaacc attaaacaga ggtaattttt atcgccgtat gatgcgtttt gatatcctga
    14101 tcaaacaaga agacctgcgt aaaggtgggg cacataaggc accctacctt tacagctttg
    14161 atcctctgaa atatcatgag tccctgcaag gactcgattg gtaaccacta tttccagcca
    14221 ccacccaatg cacggtaaag attaaccaca gcttgcattt tttgcaaatg atcacttaca
    14281 ccgcttaatt gcgctgctaa taaactttgt tctgatgtta atacatcagt gtagtttgta
    14341 gcggagctaa agcgtagtaa atcttgtgtg taatcaacgg ctttaaccag tgctgcaact
    14401 tgtttaatcc ttgaatcttc tttttctacc gcagtctgat aggcataaag tgcgtttgaa
    14461 acttcttgtc ctgctaccag taaactttgc tggaaattat ttaatgcttg tatttgcagt
    14521 gactgcgcag tctttaaacg tgctttattt aatccctggt tgaaaattgg ctgggtcaac
    14581 cctcctacta aattgtagaa gacagaatgg tcaaagaagt ctttcagggt caggtttgaa
    14641 aaaccagctg aagctgttaa agtcaaactt ggatagaaat aggttctggc caggtttgtg
    14701 ttttcaaaag cgcctctaaa agcaagctca gcctgctgaa catcaggacg attctgcaat
    14761 aactgcgcag gaacaccagt cgctaatgct gatggaacag cttgcgcttc catagtgctt
    14821 ctgtcaatag atcctggatt ttcagctaat aatatactaa ttgcgttttc tgtttcacgg
    14881 atacttcttt tcaagtctgg tatagaaact tcggtagcat aacggctcgc ctcactttga
    14941 actacggctg caccatttac tactgcccct tctttcaggg ctttcatcgt ttctacattc
    15001 gcaatcctgc tttccagtgt tttttgcgta atagccaatt gctgatctaa agccagtaat
    15061 ccataatagt tatttgcaat atcagcaatc aattgggtct gtacagcttt cttcgcagca
    15121 tctgtttcca ggtattttgc taaagctgca cgtttactgc tgcttaattt gccccagata
    15181 tctgcttccc acgaagtact catggataat ttataagtgt tggtcagcgt attgatatta
    15241 atcccgggag gaaagtttaa acccgcacta gactgtttac ttcttgtggc atttgcatct
    15301 gcactcaaag ttggcaggaa agccagtttt gcctgctgca aagaagcctg agcctgtaaa
    15361 atgttttgga ttgcattttt caggttcaca ttctgatcaa ggcctttttg gatcagtact
    15421 tttagttttt catccgtaaa cagcgtctgc catggctgtg aggccatagt tgcagagtct
    15481 gttacatttt gtccgcgata caatccatca gttttcacct ggggtgtatc gtaggttttc
    15541 gttaccgaac acgcactaaa aaaggtagcg gcgaccagta aagcaaaaac ctgtttgtta
    15601 tatttatgag tcatcttatg ctattctaaa atttaaaatc aactaagcag ttggtggttc
    15661 aagaagcttg tgttcttcgg caccttctat tcctttagtc tcttgttctt cttcctcttc
    15721 gtcatcgtca tagctttttc tcgctggccc gctgattttt tcttgtaaac tctggaatat
    15781 gataaacaat acggggatca caaatacgcc cagaatagtt ccgataagca ttcctcctac
    15841 tgcacctgta ccaattgact tgttaccaac tgcacctgca cctgtagaaa acatcagggg
    15901 tactaaacca aaaataaagg caaaggaagt catcagaatt ggtcttaaac gtgcaactgc
    15961 accttcaact gctgcctgaa caatcggcat cccgtttctt ctccggtcca atgcaaattc
    16021 tacaatcaga ataccattct tagcaagtaa tccgatcagc atgatcaggg aaatctggag
    16081 ataaatatta ctgttcagtt tgaagataat agaaaacaga taagcacctg ctaatccaaa
    16141 aggaatggat aacaatacag cgaatggaag aatataactt tcatactgtg cgcttaacag
    16201 aaagtataca aagatcagac ataaaacaaa gataaatact gtttcactac ctgaagccag
    16261 ctcttctctg gtcaaacctg aaaagtcaaa tccatatccc gcaggtaatg ttgaagctgc
    16321 tacttcctga atcgctttaa tcgcatcacc tgaactaaag cctgcgttag gtgcgcctgt
    16381 gattgatata gagctaaaca agttaaacct tgaaatagat tccgggccat ataccctggt
    16441 cattttcaca aattctgtga ttggtgccat attaccagca ctatttctca caaagatttt
    16501 gttcaatcct tctggatttg cacggaattc ggctgctgcc tggaccatca ctctgtattg
    16561 cttaccaaac ttgttaaagt tagaggcata taatccacca taataacctt gcatcgtctg
    16621 taaaactgta tttacagtga cgccggcatc tttacatttc tccagattta catccatcag
    16681 atattgtggg aaaccagggt taaaaggtgt cgtcgcatat tgaatctcag gacgctttga
    16741 tagcgcagca agaaacgtat tgtttacctt aaagaattca tcagtagtat gtccaccttt
    16801 atcttgcaat tggaactcaa atccaccact ctgaccaaag ccctggatgg ttggaggcga
    16861 aataaagaag atacttgctt ctctgatccc ggatgttttg gcaaaaagct gaccgattac
    16921 ctgatcaacg ctcagtttac gatcatccca ggtttttaac ttcaaaataa ccatactgta
    16981 tgcactacca gcacccgcgg tgaaattctg ccctacaata cgtaaggtgt tttgaactcc
    17041 aggaatcgta tgtgcaatac tatcaacctg tttagcgatc gctgttgagc gctccataga
    17101 agaagacggt ggtaaactga tatttgcaaa tattgttccc tgatcttctg ccggtacaaa
    17161 cgccgaaggt gtagttttca tcatgtaaaa caaagctgca cctgcaattg caatacttcc
    17221 caggacaatc cattttttaa cagaaagaaa ttgtacagaa cgcttgtatt tattggttaa
    17281 attatcaaat gcaacattaa aagcagtata gaacctctgt acaaaacttt gatgcttatg
    17341 gtcatctgca tgtggtttca ataataaagc acaaagcgca gggctcaaag ttaaagcgtt
    17401 aatcgctgat aagataatcg ctactgccag tgtaatacca aattgcttgt aaaatacacc
    17461 tgtagatcct gtgataaagg ttaccggaat aaatactgcc gccatcacga gcgtaatcga
    17521 aataatcgca cccgatattt cactcattgc atcaatggta gctttcttgg ctgatttata
    17581 accgttgtcg agtttggcgt ggaccgcttc gacgactaca atcgcatcat cgaccacaat
    17641 cccaatggcc agtactaaag caaaaagcgt taataagttg atcgtgaagc cgaataagtt
    17701 caggaaaaag aaagtaccaa taattgctac cggtactgca attgcaggga ctaaagtaga
    17761 ccttaaatcc tgaaggaaaa taaatacaac gataaatacc aggataaagg cttcaaccag
    17821 tgtgtggatt actttgtcaa ttgaagcatc aagattctca ttgacatcga caagcgtagt
    17881 atatttgacc ccttttggga aagttttagc agcttcttca atgatctttt ttgaattgtt
    17941 gatgacgtct cttgcattgg agccaggggt ctgactaatt gccacaccta ctgattcttt
    18001 accattggtt tcaatggtag cggtataact taatgcaccc aattcaactt tagcaacgtc
    18061 ttttaaacgt aataactgac cgttaccagc agatttaata atgatattct caaattctgt
    18121 gggtgttgtt aaacggcctt tatatttaat tacgtattga aaagcctggt tgccattttc
    18181 accaaactta cctggtgcgg cttcaatatt ctgttctgcc aatgcagcgg aaatatcgct
    18241 tggtatcaaa ctatattgtt gcatcatatc tggttttaac cagatacgca tcgaataatc
    18301 cttagaaccg aatacagttg cgtcccctac tccggtaaca cgctggattt gtggtaccag
    18361 attgatcttt gcatagtttt gcaggaatgt ctgatcataa gttttatcgt cactatataa
    18421 agcaaaaatt aacaagttac tactttgact tttcgttact gttacccctg cctgagttac
    18481 ctctgctggc aataaactgg ttgctctgga taccctgttc tgtacgttta cagctgccaa
    18541 atcgggatct gttcctactt taaagtaaat tttaatacta gctgcaccgt cattggtagc
    18601 tgtagaagtc atgtaagtca tgttctctac cccattgatc tgctcttcga gcggaataac
    18661 aatacttttt aacaccacat cagcattcgc gccactataa ttggcagaaa cgttgactgt
    18721 gggtggtgca atatctggat actgcgcaat cggcagtgaa gtgaggccaa gtatccccag
    18781 aataacaata atcacagaga ttactgtaga gagtactggt ctttgtatga atattttaaa
    18841 catttgctct tattttaagt ctgcgtagac agtttccggg ttttcagcat tcgctttgat
    18901 ctgcgtgccg tcttttaggg ttgctactcc ttctaataca atttgatctc ctgcttttaa
    18961 gccgctttcg accacgaaga aattacctgc tgtattttcc atcactgtta ctgcaacatt
    19021 tttggtcttg ccatcttgtc ctactacaac tacaaagcgt ttatcctgta actcgaaagt
    19081 tgcgctttga ggaaccagaa ttgcatcttt cacagcattg ggaattctta ctgttgcact
    19141 gcttccgcta cggataatac ctttgggatt tggaaaacgc gctctgatat ttgctgaacc
    19201 tgtagctgta ttgattaatc cgttgactgt ttctatgcgt ccttcttctg tataaggtga
    19261 tccgtcagaa agtaataaag aaactttagg tagtttggct agtttttgtg cgaaagaacc
    19321 actaccatct ttagtaaagt ctaacaataa cttttcattc agcgcaaaat aagcgtatac
    19381 gtttcctata ctcgacactg tagttaaagg atcagcagtg gtgctgctta ccagacttcc
    19441 cagacgaaat ggaatagaac cgactacccc attgacagga ctggttactg tagtgaagcc
    19501 taaattcgtt ttagcgttga ctaaactagc tttcgcagtc gctactgctg cctgcgcaga
    19561 ttcataagta tattgtgctg attccagctc atatttactt acaatatctt tttctaccag
    19621 cggctttact ttattgattg ccaactttgc agcattcagt tgtgccattg catttgcgat
    19681 actggcatta gctgttctta cttcctgctc gtattgtggt gcgctgattt tgaataatgg
    19741 ctgaccaatc tttacaacag caccttcatc tacaaatatt ttgtcgatat atccgtccac
    19801 tcttggcctg atttcgatat tctgctgtcc ttgtatactt gcaggataat ctgtatttaa
    19861 tgtggcagat ctgggttcca gtttcaggac tttgtattcc ttaacctgcc cagctgcggc
    19921 tgcggcctgt gcggccttgt ttttatcgtt gccacatgag gctagggtta atcctgtaag
    19981 gaacaggagc ccaatctgta ttgatgtttt catatttact ttttcttgct gattggtttc
    20041 tatggtgaat taatattgaa tacgatttat tttgtgggat agatcatctc aaaaatgagc
    20101 tgctttcttt ggttcattag tttatgatat tccaaatcac ttattttcag gaaactttta
    20161 ttcagattag ctgatagcaa aggataagcc attaaagcaa acaagttcat tatataatga
    20221 cggggatcca tggtctgaat atttcctttg tccatttcct ctttgatctc tgccagaaac
    20281 ggtttagtat gtgtatcgtg aaccccgtct gcgtgcgctt gattataccg gttagtttca
    20341 gtaatcagaa acaattcccg gtaaggataa gccatggtct gatccatgaa aacattgatc
    20401 agtttcttta atttttcttt aaaggtcagc tttcctgtaa acgcatctga catcatttga
    20461 cgcagttcat tcatggcctc ttctgtaacc tgctcaaata atagttttct ggacctgaaa
    20521 taatagtgga caagggttct gtt
//
