LOCUS       NZ_BBXG01000020        21497 bp    DNA     linear   CON 08-AUG-2024
DEFINITION  Herbidospora cretacea strain NBRC 15474, whole genome shotgun
            sequence.
ACCESSION   NZ_BBXG01000020
VERSION     NZ_BBXG01000020.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Herbidospora cretacea
  ORGANISM  Herbidospora cretacea
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Herbidospora.
REFERENCE   1
  AUTHORS   Komaki,H., Ichikawa,N., Oguchi,A., Hamada,M., Tamura,T. and
            Fujita,N.
  TITLE     Genome-based analysis of non-ribosomal peptide synthetase and type-I
            polyketide synthase gene clusters in all type strains of the genus
            Herbidospora
  JOURNAL   BMC Res Notes 8, 548 (2015)
   PUBMED   26452464
  REMARK    DOI:10.1186/s13104-015-1526-9 Publication Status: Online-Only
REFERENCE   2  (bases 1 to 155155)
  AUTHORS   Hosoyama,A., Oguchi,A., Ichikawa,N., Kimura,A., Ohshita,R. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 71x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001570605.1-RS_2024_08_08
            Annotation Date                   :: 08/08/2024 02:39:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,566
            CDSs (total)                      :: 7,487
            Genes (coding)                    :: 7,430
            CDSs (with protein)               :: 7,430
            Genes (RNA)                       :: 79
            rRNAs                             :: 4, 5 (5S, 16S)
            partial rRNAs                     :: 4, 5 (5S, 16S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 10 of 57
            Pseudo Genes (incomplete)         :: 49 of 57
            Pseudo Genes (internal stop)      :: 3 of 57
            Pseudo Genes (multiple problems)  :: 4 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:10:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 46827
            Orig. end                         :: 68324
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBXG01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21497
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21497
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21497
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11497](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11497)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(252..265)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.34"
                     /tool="antismash"
     gene            287..547
                     /locus_tag="AW270_RS30220"
     CDS             287..547
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542957.1"
                     /locus_tag="AW270_RS30220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6510 family protein"
                     /protein_id="WP_061299529.1"
                     /transl_table=11
                     /translation="MDYQDGNALAGPLSEIFTLDVTVAQGTCAGCGLRGPLAGLHVYGA
                     APGLVARCPGCEEVVLTLVRGPKDVWLDMRGAVSLRIPVTE"
     gene            593..1723
                     /locus_tag="AW270_RS30225"
     CDS             593..1723
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014081.4"
                     /locus_tag="AW270_RS30225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_061299530.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.5e-36, bitscore:
                     119.5, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIIRARRVFDGRDLTAKRAVVVSDGRIVELLDDAPESGDVRDLG
                     DVTLLPGLVDTHVHLAFDASPDPIAALDAPGLLDRMRAAAHAHLAVGVTTVRDLGDRGY
                     LALRLAREMTDGPEILSAGAPITSVRGHCWFLGGEAEGVDGVRKAVRERADKGAHAVKM
                     MITGGEMTPGTFSHLNQFSRAEIEAAADEARRHGLPIAGHAHSGPGILAAAEAGFDTVE
                     HVTFLTEDGVAPDPGIMATMAANGVAASLTVGVQPGFPPPPRIAALLPRLHESLRLLYE
                     SGVTIVGGSDSGIGPPKPHGILTRGGEMLSMSGMTPVEMLRAFTSDAARVCRIDRRKGR
                     IAPGFDADLLAVHGDPTIDHTALRNTAAVFRKGAPL"
     misc_feature    911..913
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1802..2605
                     /locus_tag="AW270_RS30230"
     CDS             1802..2605
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895452.1"
                     /locus_tag="AW270_RS30230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_061299531.1"
                     /transl_table=11
                     /translation="MTHALAHQYVFDNDGDHSADQHRCLADLLDPLTFARLAQTGVRDG
                     WNCLEIGAGGGSVARWLADRAAPRGHVFATDIKPGLIPPHDGLTVTRHDIVHDPLPEAA
                     FDLIHARLVLSHLTERAAVLRRLRDALKPGGWLQVDEIDVTHWPALMTPDHTARELYET
                     FLRAMASVLVDVGSDPTWGRSAAQEIAEAGFVQIDPWCHVEVWGPKSPGLELLTSNSFH
                     LEDHFLATGLTKDQLGEVRAVMADPGFRAVSFTVHSVLARRPEGT"
     gene            2605..3789
                     /locus_tag="AW270_RS30235"
     CDS             2605..3789
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131963.1"
                     /locus_tag="AW270_RS30235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isochorismate synthase MenF"
                     /protein_id="WP_063819392.1"
                     /transl_table=11
                     /translation="MDLVRTVPIQDPGPLIDAVPFSDSLLWLHGDEGMAGWGVAARFEV
                     SGPGRFEHARRWFRRWLAQRNVDDRVGLPGSGPVAFGSFTFDHGPGRSVFVIPQVLIAK
                     RGRASWMTTVGDPCHPDGTVPDPLPNVRWLAQPDARDRFHKQVSRAVEDIRAGRLHKVV
                     LARDVRGLLGGPFDPRTAVSRLNERFPGCWTFAVDGLVGASPELLTGRFGRMVKSLVLA
                     GTEWPGGAIGLGTEKTAVEHELAADSAEDVLRAHCLELDVHEPHELQLANVTHLATRIS
                     GTLSHNVDALTLASRLHPTAAVCGTPFREALALLRELENLDRGRYAGPVGWQDMRGDGE
                     WCIALRCAEVKGPDLRLFAGCGIVGDSNPASEWHETEAKLGAIRDLFAEPSCVK"
     gene            3796..4674
                     /locus_tag="AW270_RS30240"
     CDS             3796..4674
                     /EC_number="4.1.3.36"
                     /GO_function="GO:0008935 - 1,4-dihydroxy-2-naphthoyl-CoA
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009234 - menaquinone biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: ECH (27-280). E-value: 1.9e-46. Score:
                     150.3. Matches aSDomain:
                     nrpspksdomains_AW270_RS30240_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634597.1"
                     /locus_tag="AW270_RS30240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,4-dihydroxy-2-naphthoyl-CoA synthase"
                     /protein_id="WP_061299532.1"
                     /transl_table=11
                     /translation="MVSELFDEKAWRPVEGFDFADITYHRAVDQGTVRIAFNRPEVRNA
                     FRPQTVDELYRAFDHARQQVDVGCVLLTGNGPSPRDGGWAFCSGGDQRIRGKDGYQYAD
                     GTPATGRLHILEVQRQIRFMGKVVICVVPGWAAGGGHSLHVVADLTLASREHARFKQTD
                     ADVASFDGGFGSAYLARQVGQKFAREIFFLGDTYSADDAHRMGMVNAVVPHEELEVVAL
                     EWARKINGKSPTAQRMLKYSFNLIDDGLVGQQVFAGEATRLAYMTDEAAEGRDSFLEKR
                     SPDWSPFPWHF"
     aSDomain        3877..4635
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AW270_RS30240_ECH.1"
                     /evalue="1.90E-46"
                     /label="AW270_RS30240_ECH.1"
                     /locus_tag="AW270_RS30240"
                     /protein_end="280"
                     /protein_start="27"
                     /score="150.3"
                     /tool="antismash"
                     /translation="VDQGTVRIAFNRPEVRNAFRPQTVDELYRAFDHARQQVDVGCVLL
                     TGNGPSPRDGGWAFCSGGDQRIRGKDGYQYADGTPATGRLHILEVQRQIRFMGKVVICV
                     VPGWAAGGGHSLHVVADLTLASREHARFKQTDADVASFDGGFGSAYLARQVGQKFAREI
                     FFLGDTYSADDAHRMGMVNAVVPHEELEVVALEWARKINGKSPTAQRMLKYSFNLIDDG
                     LVGQQVFAGEATRLAYMTDEAAEGRDSFLEK"
     gene            4662..6311
                     /gene="menD"
                     /locus_tag="AW270_RS30245"
     CDS             4662..6311
                     /EC_number="2.2.1.9"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070204 -
                     2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
                     carboxylic-acid synthase activity [Evidence IEA]"
                     /GO_process="GO:0009234 - menaquinone biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="menD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014909210.1"
                     /locus_tag="AW270_RS30245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-succinyl-5-enolpyruvyl-6-hydroxy-3-
                     cyclohexene-1-carboxylic-acid synthase"
                     /protein_id="WP_061299533.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6e-36, bitscore:
                     116.9, seeds: 75, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALLSGNGSTALAGVVVDELARCGLAEVVVSPGSRSTALALAFHN
                     SDDIRLHVRVDERSAAFLALGLARRSGRPVALVCTSGTAAANYLPAVVEAAESGVPLLL
                     LTADRPPELRATGANQTVDQIKLYGGHVRWFCEMGAAEPGQMPYWRTTIDRAWAAMLHP
                     DPGPVHLNLAFRDPLIPSGDADKLLEGRADRQPWTAMVPPALTGDPVELPQEERGVILL
                     GDGAEDDDWEGLAEATGWPILAEPTSGFRRGPAAISTYRSLLGDPAFARVFRPGLVVTS
                     GRVGLSRAALAYIRSAERHVVVSRQGRHPDPTRTASAVVPSVRAGAPIGPTDWTATWHE
                     AEKRARDAIDLLLDTIPVSEPRLARDLVAALPSNALLFAGSSMPIRDLDLAMRPRDGIR
                     ILANRGASGIDGLVSSAIGAALAHDGPSYALLGDLSLIHDQNGLVMGPMEPRPDLTIMV
                     INNDGGGIFSTLEPAGRPEFERLFGTPHGVSARDVAAMAQVPYARVNAVSELQPSTGLW
                     VVETVTERDEQAAVRRRLQEAVSQTLATGRLL"
     gene            complement(6281..6865)
                     /locus_tag="AW270_RS30250"
     CDS             complement(6281..6865)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292870.1"
                     /locus_tag="AW270_RS30250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_061299534.1"
                     /transl_table=11
                     /translation="MASVPSDKPHLPTPVKLLIAGGFGVGKTTMVGAVSEIRPLRTEEV
                     LTDRSVGVDDLSGVEKKTTTTVAMDFGRISVGDDYVLYLFGTPGQERFWFVWDELAKGA
                     LGAVVLADTRRLSDCFPSVDYFERRGTPFVVAVNCFEGAPVYDLAEVKLALSLPPDIPV
                     LLCDARRRASGKEVLITLVQHAYSKRPVASV"
     gene            complement(6846..7205)
                     /locus_tag="AW270_RS30255"
     CDS             complement(6846..7205)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017539845.1"
                     /locus_tag="AW270_RS30255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_061299535.1"
                     /transl_table=11
                     /translation="MNPDEQLYDEQVVRPYVISRGRTEARANLDLISLAVAVRQPTGLE
                     VGLDPEHVAIVKMCVRPLSVAEIAATLDLPAGTVRVLLGDLLDAGFVAVQDPQPEVDVL
                     DERMYRAVLDGLRAL"
     gene            complement(7202..7615)
                     /locus_tag="AW270_RS30260"
     CDS             complement(7202..7615)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854124.1"
                     /locus_tag="AW270_RS30260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_061299536.1"
                     /transl_table=11
                     /translation="MTAADLAWLLDDLVSNVREVRHGIVLSSDGLLLASSRDLEMASAE
                     HLSAVAAGVQSLARGVSERFEGGAVRQTIIEMRSAYLLVTVAGKGACLAVLCEEDADVG
                     LVAYEMAMLVVRVGQYLTSPARSVASSSVRSDP"
     gene            complement(7612..9861)
                     /locus_tag="AW270_RS30265"
     CDS             complement(7612..9861)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889883.1"
                     /locus_tag="AW270_RS30265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_061299537.1"
                     /transl_table=11
                     /translation="MRLRNSRVRTKVVALLLSLAALWGFAAWVTLREGVNLLFVNTFDQ
                     GVAEPSDPLMLALQDERRASVVQLAIRRPQADLARIRVRTDQTRAHFETLARGDDVAFA
                     ASPDTRKRLDELFGLLGGLAGVRQSIDQGKINRDEAAEAYTKVLDAIFRTYFSVATLDD
                     DQIAKDARTLISLQRAREVLSQEDALLAGAIAAGRFSAGEHAKFVQIVGAQRFHTGEQV
                     AELQPADRGHFDALLDGDAFTRLRQTENAVMERGRTLEVPPVTAAQWQQTTSVALGQMM
                     DEVVAGGDRVVERATPVAMGVFVRLALAGGLGLVAVIASIVLSITTARRLVAQLEKLRE
                     AALELAEERLPGVVERLAHGEKVDVAKEAPPLEFGDDVIGQVGQAFNAVQETAIRTAVE
                     EAELRQSIRDILLSLARRTQSLVHRQLTLLDVMERRETNAEELKDLFRVDHLATRMRRN
                     AENLIVLSGATPARAWRRSVPMVDVVRGALAEVEDYTRVTIMPMGQVDLTGRAVGDVIH
                     LLAEVIENAVSFSPPYTVVQVGGHPVASGYAIEIEDRGLGMSQEDLDEANARILNPPEF
                     NLSSTARLGLYVVSRLAERHGIRVSLKSSPYGGTTAVVLLPRDLVVDDRPAEIPPAELL
                     PEAPQRLAEVTMLAAPAAQLTQRRPEPVQDTPVAPRVPEATVTEFTPSGLPFRVPQANI
                     AAPLRDAADDYAELEEDDDERSPEEIMRIMGSFQSGTRRGRTAARELQQNEGDDR"
     misc_feature    complement(9853..9855)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..11497)
                     /locus_tag="AW270_RS30270"
     CDS             complement(10001..11497)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133479.1"
                     /locus_tag="AW270_RS30270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_245674921.1"
                     /sec_met_domain="T2TS (E-value: 1.1e-87, bitscore: 288.0,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADDLVGDLMAKPWGDVSPSVYETGRLVTLAPWLAGHTERLDYL
                     CARQRPDGGWGLPDGYDLVPTLSATEGLLSALDRGDPAPRRGDPEAAAHRGVAALARLL
                     AAEPWRPLPDMPAIELIVPYLISLINDRLGPSALPLPPGMSTAPIERIRVRMKSGAQVP
                     QKLLHALEIAGDSASFAQTGVSSIGTVGASPAATAAYLGDRGLLEPGNPARLHLEAVAR
                     RFGGPVPVGLPITVFERGWVLSTLVRAGVPVDPPAEMAADLVASLGPVGTPAGPGLPPD
                     CDTTSVALYALGLLGVPYDPECLLAYELDTHFCTWQGEEGASTSTNAHVLDALGRYLTL
                     VPDAVRYRPRMDKVVTWLTERQLPDGSWTDRWHASPFYATACAALALHEYGGPAARLPV
                     ERALTWILASQREDGSWGRWAGTQEETAYALQTLLLAGDARHREAAARGHVFLSEEDDV
                     SEWPPLWHDKDLYLPVSIVRAAMIAARHLTRQNAAAYLQI"
     gene            complement(11494..12288)
                     /locus_tag="AW270_RS30275"
     CDS             complement(11494..12288)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="AW270_RS30275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /protein_id="WP_061299539.1"
                     /transl_table=11
                     /translation="MIDAHSAGRVSGLAAASARDLTACAAAHPGLFPAQPFDATLFTAV
                     SLANAFGSPDASVADLRVANRLSLWIFAVDWLVDHRAEKLSEVDAIVEECLEGEEESPL
                     TAFLGEIRAEVADGSGLFEAELARTLHAMRQEFAWKTGDELPTFAAYLDNAANFGSTLV
                     NVAHWIAGGVTGVPALIPASDEVQKVLRLLNDLATHHRDVTWGDLNALMLGPTPDEIRA
                     HIRVLVGSARELIGDGPQAGYLGRQIGYSSGFYGVADYWGSL"
     gene            complement(12285..13637)
                     /locus_tag="AW270_RS30280"
     CDS             complement(12285..13637)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="AW270_RS30280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_061299540.1"
                     /sec_met_domain="p450 (E-value: 2.3e-69, bitscore: 227.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVETSARPARPQRNLPLRRLLPMVVRAPLEGLAEVAREARGEIV
                     RLDVGPFRPYLLSHPDHLQQALRGDWTSYLRKGMFWKPIERLLGDSVIGEGPGWADSRK
                     VLQPLFTSRYVSSLTADMAATIDEGLDELTPGVTIDAMEEMNRIVTRAVISVLFGDRIS
                     PRDAEVLGPAYATANTSFGFRIALPFVPDRVPLPGDRKFMGARQVIDDVIYPLIRQART
                     EKSDGPDIISALVRARDGEGRELTDVKLRDDLASIYGAAAETTAVALTWLWPILHDHPE
                     VAAKLYAEIDEVTGDGPVDARTLPKLRYLTMVLREMLRLYPSGWAMPRMVVRTREIGGV
                     TIRAGSQVLISPYVTHRLDDFWPDPLAFRPERFDPHTEQRRSRYVYLPFGAGPHQCLGQ
                     HLFYIEAPLLIAGLLKRFRPELVTEGPFPVQPAGTLRSRKKIEMILRPVKK"
     misc_feature    complement(13836..13851)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.2"
                     /tool="antismash"
     misc_feature    13839..13854
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.22"
                     /tool="antismash"
     misc_feature    complement(13924..13938)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            14050..16236
                     /locus_tag="AW270_RS30285"
     CDS             14050..16236
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0071704 - obsolete organic substance
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012377.4"
                     /locus_tag="AW270_RS30285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 5 protein"
                     /protein_id="WP_157522830.1"
                     /transl_table=11
                     /translation="MRSAVDPAALRAAGAGSALLTALLLALNAADPTGLLAPGPVEGGL
                     TVTAFLGASYLLRRGFLATWGLVVLAAVAGRFVGTVPQGEGPLTTAWATGFTGVYLGFL
                     CWPAAIPAWIVTRRARPARGRPVPEFTLMAAFAAIGGLLVLGHSWWTHSPVGYAFGGGW
                     WFFAPTPDAGVVGGVMGLVVFLAVVHLASARLAAGPGRFVGCWLACVCGGLFLGFAQTV
                     TALFAYGPADALTTDLWPLFSLVIRMAVGVSYGAVIGLFAATATVLLPGRKRVVPALAL
                     AMALSPEATALAGPAISDAHGRQILLRGVGVNQLVDYWSGDSTKETVRPLTEADFGQMA
                     AMGFSVVRLAVSWSLLEPVPGTLDAGYVARIRRAVDQAAAHDMVTVIDLHQDAWGRGVV
                     APMGTTCPIGTTPLTGGDGAPGWATPFDGSRRCAFLRRELAPVVSRAFTDFYADRDGVQ
                     SRLVATWGRLAREFATSTAVAGFELLNDPSLGETPPLTSSAALGRFYARAVASIRAAER
                     AAGGHRHLIFFEPADLWSPWPGFARDPALVLTVKTDNLPIDPARAVALAARMAERYGTP
                     LWTNAWGEGRLEAYAKAEDDALIGGAFWVWKRACGDPELFGAGAATAGNLMVVDCATGA
                     EIAPSPSVTKVVSRAYPRAVPGRLASVSSDPERRHLRLTGTGGTGRCDLDVWAPGAARP
                     AVTSSGISGVRFREVPGGWRISGCPAGDFTLELR"
     misc_feature    14968..14970
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16434..16447
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            16473..17438
                     /locus_tag="AW270_RS30290"
     CDS             16473..17438
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014601.4"
                     /locus_tag="AW270_RS30290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ketopantoate reductase family protein"
                     /protein_id="WP_061299542.1"
                     /transl_table=11
                     /translation="MRYIIIGAGGIGGTIGARLFRSGHDVVVSARGSHLAALRSTGLRF
                     VTPNGSETLPIPAVGGPADLELREGDVLIVATKTQDTTAALEAWAPHADGLPVVCAQNA
                     VENERLALRLFSDVYGMLVWMPALHLEPGTIVAYGTPKSGMLPLGRYPQGVDKLAETIA
                     ADLDRSGFASWADPAIMRWKYGKLLGNLGNAVEALAGPGPAGRDLARRAREEGLAALTA
                     AGVDVTTPAEERDRRGDLVEHGEIAGVPRPGGSSWQSLAKGSGTIEADYLNGEIVLLGR
                     LHGVPTPVNAVLQREANRAARERRAPGSIDAAALTELVQS"
     gene            17524..18648
                     /locus_tag="AW270_RS30295"
     CDS             17524..18648
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892204.1"
                     /locus_tag="AW270_RS30295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_245674922.1"
                     /transl_table=11
                     /translation="MKTSKMSALVAALVLLAAFLVTRPAEAATVRIMPLGDSITGSPGC
                     WRALLWQRLQQTGHTDVDMVGTLGPQGCGFAYDGENEGHGGFLVTNVAAQNQLVGWLNA
                     TSPDIVMMHFGTNDVWSNRPTQQILDAYSTLVTQMRAKNPAMKILVAKIIPMNPPTCGE
                     CAARTVALNNAIPAWAAARTTAQSPIVVVDQWTGFSTATDTYDGVHPNASGDQKMSNAW
                     YPALTAAINGTTPSPSPTPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPQPGGCTAA
                     YKPGTQWGGGFQAEVVVTAGSAAISAWTVRWTFANGQQITQLWNGSHTQSGGQVTVRNA
                     VYNGNLAAGAATTFGFLASWNGANPAPTLACTSG"
     gene            complement(18801..19631)
                     /locus_tag="AW270_RS30300"
     CDS             complement(18801..19631)
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-104). E-value:
                     4.1e-12. Score: 38.1. Matches aSDomain:
                     nrpspksdomains_AW270_RS30300_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="AW270_RS30300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_061299543.1"
                     /sec_met_domain="PF00561 (E-value: 1e-09, bitscore: 31.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4e-18, bitscore:
                     60.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELVTSADGTPIEYLTVGHGPHVIVVPGALAVADDFAAFAALLA
                     GRHTVHVVQRRGRGRSGPQGGRYGIARECEDVEAVRARTGARLIFGHSFGGLVALRAAC
                     GNPAYDAVAVYEPGVSAGGSIPVGWIERARREVAEGRNEAAFLTFIRGVNPEQTGRVPR
                     WLLTVILRFAMPRAERARKLALMPQTIGEHAEVGRLDPHLADYRTVEAPVLIMHGQSAQ
                     TAALPRLAETIPRAETATFPGLDHFAPEKKPAELTDAVMGFFAAHIRTDAPAEE"
     CDS_motif       complement(19320..19370)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW270_RS30300_0001"
                     /evalue="4.70E-05"
                     /label="NRPS-te1"
                     /locus_tag="AW270_RS30300"
                     /protein_end="104"
                     /protein_start="87"
                     /score="15.9"
                     /tool="antismash"
                     /translation="LIFGHSFGGLVALRAAC"
     aSDomain        complement(19320..19568)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AW270_RS30300_Abhydrolase_1.1"
                     /evalue="4.10E-12"
                     /label="AW270_RS30300_Abhydrolase_1.1"
                     /locus_tag="AW270_RS30300"
                     /protein_end="104"
                     /protein_start="21"
                     /score="38.1"
                     /tool="antismash"
                     /translation="PHVIVVPGALAVADDFAAFAALLAGRHTVHVVQRRGRGRSGPQGG
                     RYGIARECEDVEAVRARTGARLIFGHSFGGLVALRAAC"
     gene            19714..20610
                     /locus_tag="AW270_RS30305"
     CDS             19714..20610
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014906.4"
                     /locus_tag="AW270_RS30305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_061299544.1"
                     /transl_table=11
                     /translation="MTDRPLYLRIADEIAADIRSGRLPEGRPAPSTRQIVRDRGVAMAT
                     ATKVIGTLRDQGLVETVPGRGTVVRRRGAAPRPSRSRLSAAEIVEAAVEIADAEGLALV
                     TMRRVAVSLGASTMALYRHVPNRNDLTLRMADHVFTGARLPDIRLADWRRRLEVAARLF
                     WAVFSRHPWAAEIFSLSRPQLLPNVLPIAEWSFATLHAMGFSAHDMLCTHINLFGQVRG
                     MALVRLAEARAEEDTGMSADDWMRVRGGDLGRWASDHPGVGHVVQEEFDFDLDTIFEFG
                     LQRLLDGVAAHHRALGL"
     gene            complement(20607..21275)
                     /locus_tag="AW270_RS30310"
     CDS             complement(20607..21275)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887210.1"
                     /locus_tag="AW270_RS30310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator"
                     /protein_id="WP_061299545.1"
                     /transl_table=11
                     /translation="MTRILVVDDEPQLLRALRINLAAREYDVAVAPDGAAALRLAADWH
                     PDLVVLDLGLPDLDGVEVIHGLRGWTKVPIIVLSGRAGSTDKVGALDAGADDYVTKPFG
                     IDELLARIRAVTRRTASSGGEPVTVKIGDHVVDLSDKTISGGVRLTPTEWHLLEILVRN
                     PGKLISQRQLLTEVWGPAYLKETHYLRQYFAQLRRKLESDPAHPIHLVTEPGMGYRFQP
                     "
     misc_feature    21307..21323
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     misc_feature    21432..21446
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
ORIGIN
        1 cgaccccggc cagctcttct acgccgacga gctggagaag gtgatggcgg gggtcgaggt
       61 ggcctatctc tacacccgga tcgccccgcc cgacgcgggc cgcgccgccg ggcgtctcca
      121 ggcggccgac ctaatcgcct acggctggcc gccggagacc gcacccgacg tctacgtctg
      181 cggcccgacg gggttcgtcg aggccgcggc cgacctgctg accgggctgg gccacgaccc
      241 ggccaagatc agaaccgagc gtttcggacc caccggaggc tgacccatgg actaccagga
      301 cggcaacgcc ctcgccgggc cgctgagcga gatcttcacc ctcgacgtca ccgtggcgca
      361 gggcacctgc gcgggctgcg gcctgcgggg cccgctggcc gggctgcacg tctacggcgc
      421 cgcccccggc ctggtggccc gctgccccgg gtgcgaggag gtcgtgctga cgctggtcag
      481 ggggccgaag gacgtctggc tcgacatgcg gggggcggtg tcgctcagga tcccggtcac
      541 tgagtagccc catactcaag cgcgcgaccg gaaatgggcg gatagtcggc acatgcccat
      601 cattcgcgcg cgccgcgtct tcgacggcag ggatctgacc gccaagcggg ccgtcgtcgt
      661 ctcggacggc aggatcgtcg aactgctcga cgacgcgccc gagagcggcg acgtccgcga
      721 cctcggcgac gtcaccctgc tgccggggct cgtcgacacc cacgtccacc tggccttcga
      781 cgcctccccc gacccgatcg cggccctcga cgccccgggc ctgctcgacc ggatgcgcgc
      841 cgccgcccac gcccacctgg ccgtcggcgt caccacggtg cgcgacctgg gcgaccgcgg
      901 ctacctggcc ttacgcctgg cccgggagat gaccgacggg ccggagatcc tcagcgccgg
      961 agccccgatc acctcggtca gagggcactg ctggttcctc gggggcgagg ccgagggggt
     1021 cgacggcgtg cgcaaggccg tccgcgaacg ggccgacaag ggcgcccacg ccgtcaagat
     1081 gatgatcacg ggcggcgaga tgacgcccgg gaccttctcc cacctcaacc agttcagccg
     1141 ggccgagatc gaggcggcgg ccgacgaggc gcgccgtcac gggctgccga tcgccgggca
     1201 cgcccacagc gggccgggca tcctggccgc ggccgaggcc gggttcgaca cggtcgagca
     1261 cgtcaccttc ctgaccgagg acggcgtcgc ccccgacccc gggatcatgg cgaccatggc
     1321 cgcgaacggc gtggccgcct cgctgaccgt cggcgtccag cccggcttcc cgccgccgcc
     1381 gaggatcgcc gcgctgctgc cccggctcca cgagagcctg cgcctgctgt acgagtcggg
     1441 cgtcaccatc gtcggcggca gcgactcggg catcggcccg cccaagcccc acggcatcct
     1501 cacccgcggc ggggagatgc tgtccatgtc cgggatgacc ccggtcgaga tgctgcgcgc
     1561 gttcacctcc gacgccgcca gggtctgccg gatcgaccgc aggaagggcc ggatcgcgcc
     1621 cggcttcgac gccgacctcc tcgccgtgca cggcgacccc acgatcgatc acaccgctct
     1681 ccggaacacc gccgccgtgt ttcggaaggg cgcaccactc tgagtgtctg ccgatgacct
     1741 gatgtgatca cggcctagca tgcggaaccg gactgcttgt ctttcccggg ggggaaatcc
     1801 gatgacgcat gcgctcgcgc accaatatgt cttcgacaac gacggcgacc actccgccga
     1861 ccagcaccgc tgcctggccg acctgctcga cccgctgacc ttcgcccggc tcgcccagac
     1921 cggcgtccgg gacggctgga actgcctgga gatcggggcc ggcggcggca gcgtcgcgcg
     1981 gtggctggcc gaccgggccg cgccgcgcgg ccacgtcttc gccaccgaca tcaagccggg
     2041 gctcatcccg ccgcacgacg ggctcaccgt cacccggcac gacatcgtgc acgacccgct
     2101 gccagaggcg gcgttcgacc tgatccacgc ccggctcgtg ctcagccacc tgaccgagcg
     2161 ggcggcggtc ctgcggcggc tgcgcgacgc gctgaagccg ggcggctggc tgcaggtcga
     2221 cgagatcgac gtcacccact ggcccgccct gatgacgccc gaccacaccg cccgggagct
     2281 ctacgagacg ttcctgcgcg cgatggcctc ggtgctggtc gacgtgggca gcgacccgac
     2341 gtgggggcgt tcggccgccc aggagatcgc cgaggccggg ttcgtccaga tcgacccgtg
     2401 gtgccacgtc gaggtgtggg ggccgaagtc gcccggcctg gaactgctca ccagcaacag
     2461 cttccacctg gaggaccact tcctggccac cggcctgacg aaggaccagc tcggcgaggt
     2521 gcgggcggtc atggccgacc cggggttccg cgcggtctcc ttcaccgtcc actcggtgct
     2581 ggcgcgccgg ccagagggga cctgatggac ctggtgcgga cggttccgat ccaggatccg
     2641 ggcccgctga tcgacgccgt gcccttctcc gacagcctgc tgtggctgca cggcgacgag
     2701 ggcatggccg ggtggggggt cgcggcccgg ttcgaggtga gcgggcccgg ccggttcgag
     2761 cacgcccgcc gctggttccg gcgctggctg gcccagcgca acgtcgacga ccgggtgggc
     2821 ctgccgggct cgggtccggt cgcgttcggc agcttcacct tcgaccacgg gccggggcgg
     2881 tcggtgttcg tgatcccgca ggtcctcatc gccaagcgcg gccgcgcgtc gtggatgacg
     2941 accgtgggcg acccctgcca tcccgatgga acggtcccgg acccgctgcc gaacgtccgc
     3001 tggctggcgc agcccgacgc ccgcgaccgc ttccacaagc aggtgagcag ggcggtcgag
     3061 gacatccgcg ccgggcggct gcacaaggtc gtgctggcca gggacgtgcg ggggctgctg
     3121 ggcgggccct tcgacccgcg cacggcggtc tcccggctga acgagaggtt ccccggctgc
     3181 tggacgttcg ccgtcgacgg cctggtgggc gcctcgcccg agctgctgac cgggcggttc
     3241 ggccggatgg tgaagtcgct ggtgctggcc ggcaccgagt ggcccggcgg ggcgatcggc
     3301 ctgggcaccg agaagaccgc ggtggaacac gaactggccg ccgactcggc cgaggacgtg
     3361 ctgcgggccc actgcctgga gctcgacgtc cacgagccgc acgagctgca actggccaac
     3421 gtcacccacc tggcgacccg gatcagcggc acgctcagcc acaacgtcga cgcgctcacc
     3481 ctggcctcgc ggctccatcc gaccgccgcc gtctgcggca ccccgttccg ggaggccctg
     3541 gcgctgctgc gcgagctgga gaacctcgac cgggggcgct acgccggccc cgtcggctgg
     3601 caggacatgc gcggcgacgg cgagtggtgc atcgcgctgc gctgcgccga ggtgaagggg
     3661 cccgacctcc ggctgttcgc cggatgcggc atcgtgggcg actcgaaccc cgcctcggag
     3721 tggcacgaga ccgaggcgaa gctcggcgcc atccgggatc tgttcgccga accctcctgc
     3781 gtaaagtgag acagcatggt ttctgaactg ttcgacgaga aggcgtggcg ccctgtcgag
     3841 ggcttcgact tcgccgacat cacctaccac cgggcggttg atcagggcac ggttcggatc
     3901 gccttcaacc gtcccgaagt gcgcaacgcc ttccgcccgc agacggtcga cgagctctac
     3961 cgggccttcg accacgcccg ccagcaggtc gacgtgggct gcgtgctgct gaccggcaac
     4021 ggcccctcgc cccgcgacgg cggctgggcg ttctgctccg gcggcgacca gcgcatccgg
     4081 ggcaaggacg gctaccagta cgccgacggc accccggcca ccggccgcct ccacatcctg
     4141 gaggtgcagc ggcagatccg cttcatgggc aaggtcgtca tctgcgtggt gccgggctgg
     4201 gcggcgggcg gcggccacag cctccacgtg gtggccgacc tgacgctcgc cagccgtgaa
     4261 cacgccaggt tcaagcagac cgacgccgac gtcgccagct tcgacggcgg tttcggcagc
     4321 gcctacctgg cccgccaggt gggccagaag ttcgcccgcg agatcttctt cctgggcgac
     4381 acctacagcg ccgacgacgc ccaccgcatg ggcatggtca acgcggtcgt gccccacgag
     4441 gagctggagg tcgtcgcgct ggagtgggcc cgcaagatca acggcaagag cccgaccgcg
     4501 cagcggatgc tcaaatactc gttcaacctg atcgacgacg gactggtggg ccagcaggtg
     4561 ttcgcggggg aggcgacgcg gctggcgtac atgaccgacg aggcggccga aggccgcgac
     4621 tccttcctgg agaaacgctc acccgattgg agcccgttcc catggcactt ctgagcggga
     4681 acggctcgac ggcgctggcc ggggtggtcg tcgacgaact ggcccgctgc gggctggccg
     4741 aggtcgtcgt ctcccccggc tcacggtcca ccgccctcgc gctggccttc cacaacagcg
     4801 acgacatccg gctccacgtg cgggtcgacg agcgctcggc ggcgttcctg gcgctgggcc
     4861 tggcccggcg gtcgggccgc ccggtggctc tggtctgcac gtccggcacc gccgccgcca
     4921 actacctgcc cgccgtggtc gaggccgccg agtcgggcgt cccgctgctg ctgctgacgg
     4981 ccgaccggcc gccggagctg cgggcgaccg gtgccaacca gacggtcgac cagatcaagc
     5041 tctacggcgg ccacgtgcgc tggttctgcg agatgggcgc ggccgagccc ggccagatgc
     5101 cctactggcg gaccacgatc gaccgggcct gggcggccat gctccacccc gacccggggc
     5161 cggtccacct caacctcgcc ttccgcgacc cgctcatccc gtcgggcgac gccgacaagc
     5221 tgctggaggg ccgggccgac cgccagccgt ggacggccat ggtcccgccc gcgctcacgg
     5281 gcgatccggt ggagctgccg caagaggagc gcggggtcat cctgctcggc gacggcgcgg
     5341 aggacgacga ctgggagggc ctggccgagg cgaccggctg gccgatcctg gccgagccga
     5401 ccagcggttt ccggcgcggc ccggcggcga tctcgaccta ccgcagcctg ctcggcgacc
     5461 cggcgttcgc gcgggttttc cgccccggcc tggtcgtgac gtcgggccgg gtgggcctgt
     5521 cgcgggcggc gctggcctac atccggtcgg ccgaacgcca cgtcgtggtg tcgcggcagg
     5581 gccgccaccc cgacccgacg cggaccgcct cggccgtggt cccgtcggtc cgggccggtg
     5641 cgccgatcgg cccgaccgac tggacggcca cctggcacga ggccgagaaa cgcgcccgcg
     5701 acgccatcga cctgctgctc gacacgatcc cggtgagcga gccccggctg gcccgcgacc
     5761 tggtggcggc gctgccgtcc aacgcgctgc tgttcgccgg gtcgagcatg ccgatccgcg
     5821 acctcgacct ggccatgcgg ccgcgcgacg ggatcaggat cctggccaac cggggcgcct
     5881 cgggcatcga cggcctggtg tcgtcggcga tcggcgcggc gctggcccac gacggcccgt
     5941 cgtacgccct gctcggcgac ctgtccctga tccacgacca gaacggcctg gtcatgggcc
     6001 cgatggagcc ccggcccgac ctgacgatca tggtgatcaa caacgacggc ggcggcatct
     6061 tctcgaccct ggaaccggcc ggccgcccgg agttcgagcg cctgttcggc acgccccacg
     6121 gcgtcagcgc ccgcgacgtc gccgcgatgg cccaggtgcc ctacgcccgg gtcaacgccg
     6181 tcagcgagct gcagccgtcc accggcctgt gggtcgtcga gacggtcacc gaacgcgacg
     6241 agcaggcggc cgtgcggcgg cggctccagg aggcggtgtc tcagacgctg gcgaccgggc
     6301 gcttgctgta ggcgtgctgc acgagggtga tcagcacctc cttgccggag gcgcggcggc
     6361 gcgcgtcgca cagcagcacc gggatgtccg gtggcaggct gagcgccagc ttcacctcgg
     6421 ccaggtcgta gaccggggcg ccctcgaagc agttcaccgc gaccacgaac ggcgtgccgc
     6481 gccgctcgaa gtagtcgacc gacgggaagc agtcggacag acgccgggtg tcggccagca
     6541 cgacggcgcc cagggcgccc ttggccagct cgtcccagac gaaccagaac cgctcctggc
     6601 cgggggtgcc gaacaggtag agcacgtagt cgtcgccgac gctgatccgg ccgaagtcca
     6661 tcgccaccgt ggtggtcgtc ttcttctcga cgccggacag gtcgtcgacg ccgacgctgc
     6721 ggtcggtcag cacctcctcg gtgcgcagcg gccggatctc cgacaccgcg ccgaccatcg
     6781 tcgtcttgcc caccccgaag ccgcccgcga tcagcagctt caccggggtg ggcaggtgag
     6841 gcttgtcaga gggcacggag gccatcgagc accgccctgt acattcgctc gtcgaggacg
     6901 tccacctcgg gctgcggatc ctggaccgcc acgaaaccgg cgtcgagcag gtcgccgagc
     6961 agcacccgga ccgtgcccgc gggcaggtcg agggtggccg cgatctcggc gaccgacagc
     7021 gggcggacgc acatcttcac gatcgccacg tgttcggggt cgagcccgac ctccaggccg
     7081 gtcggctgcc tgacggccac cgccagggag atcaggtcga ggttcgcgcg ggcctcggtt
     7141 cggccgcgcg agatgacata gggacggacg acctgctcgt cgtagagttg ctcgtcaggg
     7201 ttcacgggtc gctcctgacc gaagaagacg ccacggaccg tgcgggagac gtcaggtact
     7261 gcccgacgcg gaccacgagc atcgccatct cgtaggcgac caggccgacg tcggcgtcct
     7321 cctcgcagag cacggcgagg caggcgccct tgccggcgac cgtcaccagc aggtaggccg
     7381 accgcatctc gatgatggtc tgccggacgg cgccgccctc gaaccgttcg ctcacgccgc
     7441 gcgccagcga ctgcaccccg gcggcgaccg ccgacaggtg ctcggcgctg gccatctcca
     7501 ggtcgcgtga gctcgccagc agcagcccgt cggaggacag cacgatgccg tgccgcacct
     7561 ccctgacgtt gctgaccagg tcgtcgagga gccaggcgag gtcggccgcg gtcaccgatc
     7621 gtccccttcg ttctgttgga gttcgcgggc cgcggtccgg ccgcgccggg tgcccgactg
     7681 gaacgagccc atgatgcgca tgatctcttc gggcgaccgt tcgtcgtcgt cttcttcgag
     7741 ttcggcgtag tcgtcggccg cgtcgcgcag cggcgcggcg atgttcgcct gggggacgcg
     7801 gaagggcaga cctgaggggg tgaactcggt cactgtggcc tccgggacgc gcggagcgac
     7861 aggggtgtcc tgcacgggct cagggcggcg ctgggtcagc tgcgccgccg gcgcggcgag
     7921 catggtgacc tcggcgagcc tctggggcgc ctcgggcagc agctcagccg gggggatctc
     7981 ggcgggccgg tcgtcgacga ccagatcgcg cggcagcagc acgacggcgg tcgtgccgcc
     8041 gtagggggag ctcttgagcg agaccctgat gccgtggcgt tcggccaggc ggctgaccac
     8101 gtagaggccg agccgggcgg tgctcgagag gttgaactcc ggcgggttga ggatgcgggc
     8161 gttggcctcg tcgaggtcct cctgggacat gcccaggccc cggtcctcga tctcgatggc
     8221 gtagccgctg gcgaccgggt ggccgccgac ctgcacgacc gtgtagggcg gcgagaacga
     8281 cacggcgttc tcgatcacct cggcgagcag gtggatgacg tcgccgacgg cccgtccggt
     8341 caggtcgacc tggcccatcg gcatgatcgt cacgcgggtg tagtcctcga cctcggcgag
     8401 cgcgccgcgc accacgtcga ccatcgggac ggaccggcgc caggcgcggg ccggggtcgc
     8461 gccggagagc acgatgaggt tctcggcgtt gcggcgcatg cgggtggcga ggtggtcgac
     8521 ccggaacagg tccttgagct cctcggcgtt ggtctcgcgg cgctccatga cgtcgagcag
     8581 ggtgagctgg cggtgcacga gcgactgggt gcgccgggcc aggctgagca ggatgtcgcg
     8641 gatcgactgc cggagctcgg cctcctcgac ggcggtccgg atcgcggtct cctggacggc
     8701 gttgaacgcc tggcccacct ggccgatgac gtcgtcgccg aactccagcg gcggcgcctc
     8761 cttggcgacg tcgaccttct cgccgtgggc gagccgctcg accacgccgg gcagccgctc
     8821 ttcggccagt tcgagggcgg cctcgcggag cttctccagc tgcgcgacca gccgccgcgc
     8881 ggtggtgatc gacagcacga tggacgcgat gacggccacc aggccgagac cgccggccag
     8941 cgccagccgc acgaacacgc ccatcgcgac cggggtggcc cgctcgacca cccggtcgcc
     9001 gccggcgacg acctcgtcca tcatctggcc gagcgcgacg gaggtggtct gctgccactg
     9061 ggccgccgtg acgggcggca cctccagcgt ccggccgcgt tccatcacgg cgttctcggt
     9121 ctggcggagc cgggtgaacg cgtcgccgtc gagcagggcg tcgaagtggc cccggtcggc
     9181 gggctgcaat tcggcgacct gctcgccggt gtgaaaacgc tgggcgccga cgatctgcac
     9241 gaatttggcg tgttcaccgg cactgaaacg gccggccgca attgctccgg cgaggagcgc
     9301 gtcttcctgt gagagaactt cgcgggcgcg ctggaggctg atgagagtgc gggcgtcctt
     9361 cgcgatttgg tcgtcgtcga gcgtcgcgac ggagaaatag gtgcggaaga tggcgtcgag
     9421 caccttggtg taggcctcgg ccgcctcgtc gcggttgatc ttgccctggt cgatcgactg
     9481 acgaactccg gccagcccgc ccagcaggcc gaacagctcg tcgaggcgct tgcgcgtgtc
     9541 ggggctggcg gcgaaggcga cgtcgtcgcc cctggccagg gtctcgaagt gggctctggt
     9601 ctggtcggtc cggacgcgga tccgggccag gtcggcctgc ggccggcgga tggcgagctg
     9661 gacgaccgac gcgcgccgtt cgtcctggag ggccagcatg agcgggtcgc tgggctcggc
     9721 gacaccctgg tcgaaggtgt tcacgaaaag gaggttgacg ccttcccgaa gggtgaccca
     9781 ggccgcgaac ccccaaagag ccgcgaggga caggaggagc gccaccacct tggtccgcac
     9841 tcgggaattg cgtaagcgca tatcaaccac cttgggcgtt tcccggcgat ttccaacggt
     9901 tcaccgctta gcgggattac cggggcgcaa gccgcaagcg ccccggggaa ccttagcaat
     9961 gccgggaaac acactcaact cacgtgtctc atttatgtgc tcatatctga aggtaggccg
    10021 ccgcattctg tcgtgtaaga tgacgcgctg cgatcatggc cgcccggacg atcgaaacag
    10081 gcaggtacag gtccttgtca tgccacagcg gcggccattc cgagacgtcg tcctcttcgg
    10141 acaggaaaac gtgcccgcgg gccgccgcct cgcggtgacg ggcgtcgccg gccagcagga
    10201 gcgtctgcag ggcgtaggcc gtctcctcct gagtgccggc ccacctgccc cacgacccgt
    10261 cctcccgctg actggcgagg atccaggtca gcgccctctc gaccgggagc cgggcggccg
    10321 ggccgccgta ctcgtgcagg gcgagggcgg cgcaggcggt ggcgtagaag gggctggcgt
    10381 gccagcggtc ggtccaggag ccgtcgggga gttgcctctc ggtgagccag gtgaccacct
    10441 tgtccatccg ggggcgatag cggacggcgt ccggcacgag ggtcaggtaa cggccgagcg
    10501 cgtcgaggac gtgggcgttc gtgctggtgg aggcgccttc ttcgccttgc caggtgcaga
    10561 agtgggtgtc gagctcgtag gcgagcaggc actcggggtc gtacgggacg ccgagcagcc
    10621 ccaaggcgta gagggccacc gacgtggtgt cgcagtcggg cggcagaccc ggtccggccg
    10681 gggtgcccac cggaccgaga ctggccacca ggtcggccgc catctcggcc ggcgggtcga
    10741 cggggacacc cgccctgacc agtgtgctca acacccagcc gcgctcgaag acggtgatcg
    10801 gcaggcccac cggcaccggc ccgccgaacc tgcgggccac cgcctccagg tgcaggcggg
    10861 ccgggttgcc gggctccagg agcccccggt cccccaggta ggccgcggtc gcggcgggag
    10921 aagcgccgac cgtgccaata gaagaaactc ctgtttgcgc aaaagacgcg gaatccccag
    10981 ctatttccaa ggcatggagc aatttctgtg gaacttgcgc gccggatttc atccggacgc
    11041 gaattctttc gatcggggcg gtgctcatgc cgggcgggag gggcagggcc gacgggccga
    11101 gacgatcgtt gatcaggctg atcaggtacg gcacgatcag ctcgatcgcc ggcatgtcgg
    11161 gcagcggccg ccacggctcg gcggccagca ggcgcgccag cgcggccacg ccccggtggg
    11221 cggcggcctc cggatcgccc cggcgcgggg ccggatctcc ccggtcgagc gcggacagca
    11281 ggccctcggt cgcggacagg gtcggcacca ggtcgtagcc gtcgggcagg ccccagccgc
    11341 cgtcgggccg ctgccgggcg cacaggtagt cgaggcgttc ggtgtgcccg gccagccagg
    11401 gggccagggt gaccaggcgg ccggtctcgt agaccgacgg cgacacgtcg ccccacggct
    11461 tggccatcag atcgccgacc aggtcgtcgg cgctcacagg cttccccagt agtcggcgac
    11521 gccgtagaag ccggagctgt agccgatctg gcggcccaga tatccggcct gggggccgtc
    11581 gccgatgagc tcgcgcgcgc tgccgaccag gacgcggatg tgggcgcgga tctcgtcggg
    11641 ggtcgggccg agcatcaggg cgttgaggtc gccccaggtc acgtcccggt ggtgggtggc
    11701 caggtcgttg agcaggcgca gcaccttctg cacctcgtcg ctggccggga tcagcgcggg
    11761 caccccggtg acgccgccgg cgatccagtg ggcgacgttg accagcgtcg atccgaagtt
    11821 ggcggcgttg tcgagatagg cggcgaaggt gggcagctcg tcgccggtct tccaggcgaa
    11881 ctcctggcgc atggcgtgca gcgtccgggc gagctcggcc tcgaagaggc cgctgccgtc
    11941 ggcgacctcg gcgcggatct cacccaggaa ggcggtcagc gggctctcct cctcgccttc
    12001 gaggcactcc tccacgatcg cgtcgacctc ggagagcttc tcggcgcggt ggtcgaccag
    12061 ccagtcgacc gcgaagatcc agagcgacag ccggttggcc acccgcagat cggccacgct
    12121 ggcgtcgggc gagccgaagg cgttggccag cgagacggcg gtgaacaggg tcgcgtcgaa
    12181 cggctgggcc gggaagagcc cgggatgggc ggcggcgcag gcggtcaggt cgcgcgcgga
    12241 ggccgccgcc aggccgctca cccggccggc gctgtgggcg tcgatcactt cttcaccggg
    12301 cgcaggatca tctcgatctt cttgcggctg cgcagcgtgc cggccggctg caccgggaac
    12361 ggcccctcgg tcaccagctc gggccggaac cgcttgagca gcccggcgat cagcagcggc
    12421 gcctcgatgt agaacaggtg ctgcccgagg cactggtgcg ggcccgctcc gaacggcagg
    12481 tagacgtagc ggctgcggcg ctgctcggtg tgcgggtcga accgctcggg ccggaaggcc
    12541 agcgggtcgg gccagaagtc gtccaggcgg tgggtgacat aggggctgat gagcacctgc
    12601 gacccggccc tgatggtgac cccgccgatc tcgcgggtcc gcacgaccat gcgcggcatc
    12661 gcccatccgg acgggtagag gcggagcatc tcgcgcagca ccatggtcag gtagcgcagc
    12721 ttcggcaggg tccgggcgtc gaccgggccg tcgccggtga cctcgtcgat ctcggcgtag
    12781 agcttcgcgg ccacctcggg gtggtcgtgc aggatcggcc acagccaggt gagcgcgacc
    12841 gcggtggtct cggcggcggc gccgtagatg ctggccaggt cgtctctcag cttgacgtcg
    12901 gtgagctcgc gaccctcgcc gtcgcgggct cggaccagcg ccgagatgat gtcgggcccg
    12961 tcgctcttct ccgtgcgggc ctgccggatc agcgggtaga tcacgtcgtc gatgacctgc
    13021 cgggcgccca tgaacttccg gtcgccgggc agcggcaccc ggtcgggcac gaacggcagc
    13081 gcgatccgga agccgaagga ggtgttcgcg gtggcgtacg cgggcccgag gacctcggcg
    13141 tcgcgcgggg agatccggtc gccgaacagc accgagatga ccgcgcgggt gacgatgcgg
    13201 ttcatctcct ccatcgcgtc gatcgtcacg ccgggggtga gttcgtcgag gccctcgtcg
    13261 atcgtcgccg ccatgtcggc ggtgagcgag gagacgtacc gggaggtgaa gagcggctgg
    13321 aggaccttgc ggctgtcggc ccagccgggc ccctcgccga tcacgctgtc gccgagcagc
    13381 cgctcgatgg gcttccagaa catgcccttg cgcaggtagc tcgtccagtc gccgcgcagc
    13441 gcctgctgga ggtggtcggg gtggctcagc agatagggcc ggaacggccc gacgtccagc
    13501 cggacgatct caccccgggc ctctcgtgcc acctcggcca ggccctccag gggcgctcgg
    13561 acgaccatcg gcagcagccg gcgcaacggc aggttgcgct ggggccgggc gggtctcgcg
    13621 gatgtctcga cggacatttc ttggtgctcc ccacaggtat ggatacgcgc agcgcaaaca
    13681 gcgctcacgg cggatgagcg cttgaatggt ccaagagagt cgtgcggtgg atgacattcc
    13741 gtggagtgtc ggatacctcc atttcactgg caatatgtcg tacctgtgat gctttgccat
    13801 ctctactgca ccaccggcgc agtatcacat gatcaaatga cgatgatcaa tattgcaggg
    13861 tagtgacacc tttgtgggca cctgaccgaa atacatggat cggtcccaat tgccggattt
    13921 gagataccaa aatgggaatc tgacccgccg gaacacctct agtcgagagg cctgtggggc
    13981 tggttggatc acggggtgcc ccgtcacgtc cctgtgatgt ccggcgtgac gtcccgcgtg
    14041 tcgtccgcca tgagatccgc tgtggacccc gccgccctcc gcgccgccgg tgccggatct
    14101 gccctgctca cggcgctgct cctggccctg aacgcggccg accccaccgg cctgctggcc
    14161 cccggtcccg tcgagggcgg gctgaccgtc accgccttcc tcggcgcctc ctacctgctg
    14221 cggcggggtt tcctcgcgac gtggggcctg gtcgtgctgg ccgccgtcgc ggggcgcttc
    14281 gttgggaccg ttccgcaggg cgaggggccg ctgaccaccg cgtgggcgac cgggttcacc
    14341 ggggtctacc tgggctttct ctgctggccc gccgcgatcc cggcttggat cgtgacacgc
    14401 cgggcccgcc ccgcgcgggg acggccggtg ccggagttca cgctgatggc ggcgttcgcg
    14461 gcgatcggcg ggctgctcgt gctcgggcac tcgtggtgga cgcactcccc cgtcggctac
    14521 gccttcggcg gcggctggtg gttcttcgcg ccgacccccg acgccggggt cgtcggcggg
    14581 gtcatggggc tcgtggtctt cctcgccgtc gtccacctcg cctcggcccg gctggcggcg
    14641 ggcccggggc ggttcgtcgg gtgctggctc gcgtgcgtct gcggcgggct gttcctgggc
    14701 ttcgcccaga cggtcacggc ccttttcgcg tacggccccg ccgacgccct gaccaccgac
    14761 ctgtggccgc tgttctccct ggtcatcagg atggcggtgg gcgtctccta cggcgcggtg
    14821 atcggcctgt tcgcggccac ggccaccgtc ctgctgcccg gccggaagag ggtggtgccc
    14881 gcgctggccc tggcgatggc gctgtcaccg gaggccaccg ccctggccgg tccggcgatc
    14941 agcgacgccc acggccgcca gatcctctta cgcggcgtcg gggtgaacca gctcgtcgac
    15001 tactggagcg gcgactccac caaggagacc gtacgccccc tgaccgaggc cgacttcggg
    15061 cagatggccg cgatgggctt ctcggtggtc cgcctggccg tctcctggtc gctgctcgaa
    15121 cccgtccccg gcacgctcga cgccggctac gtcgcccgca tccgccgcgc ggtcgaccag
    15181 gccgccgccc acgacatggt caccgtcatc gacctgcacc aggacgcctg gggccggggc
    15241 gtcgtcgccc cgatgggcac cacctgcccg atcggcacca ccccgctgac cggcggggac
    15301 ggcgcgcccg gctgggccac cccgttcgac ggcagcaggc gctgcgcgtt cctgcgcagg
    15361 gagctggccc cggtggtcag ccgggccttc accgacttct acgccgaccg cgacggcgtc
    15421 cagtcgcggc tggtcgcgac ctggggacgg ctggcccgcg agttcgccac ctcgaccgcg
    15481 gtcgccgggt tcgagctctt gaacgacccc agtctcggcg agaccccgcc gctgacctcc
    15541 tcggccgccc tcggccgttt ctacgcccgc gccgtcgcgt ccatccgggc cgccgaacgg
    15601 gcggcgggcg gccaccgcca cctgatcttc ttcgagccgg ccgacctgtg gtcgccctgg
    15661 cccggcttcg cccgcgatcc cgccctggtg ctgaccgtca agacagacaa cctgccgatc
    15721 gacccggccc gcgcggtcgc cctcgccgcc cggatggccg agcgctacgg caccccgctg
    15781 tggaccaacg cgtggggcga ggggcggctg gaggcgtacg cgaaagcgga ggacgacgcc
    15841 ctgatcggcg gcgcgttctg ggtgtggaag cgggcctgcg gcgaccccga gctgttcggc
    15901 gccggcgcgg cgaccgccgg gaacctgatg gtcgtcgact gcgcgaccgg cgcggagatc
    15961 gccccgtcac cctccgtgac caaggtggtg agcagggcct acccgagggc ggtgccgggc
    16021 cgcctcgcct cggtgtcgtc ggacccggag cgtcgccacc tgcggctgac cggaaccggg
    16081 ggaaccggac ggtgcgatct cgacgtgtgg gcgccgggcg cggcccgccc ggcggtgacg
    16141 tcgtcgggga tctccggcgt gaggttccgt gaagtgcccg gcggctggcg gatctccggc
    16201 tgcccggcgg gcgatttcac gctggaactg cggtgatacg cccggatcag gcggtcgcgg
    16261 tgatcagcca ggcgaggccc agcaggatga cgaccgggat cagccagacg acgacctcga
    16321 tcgcgaactc cttgtacatg agccttcctt tccttgaggt ccgcagtttt cgatccgcag
    16381 catattgggt gacccgaaat ccgcagtagt cagcgttccg ccgtcacggt gacggaactc
    16441 tccgtgacgg cgaagccggg cagaatcggc gcatgcgcta catcatcatc ggagccggcg
    16501 gcatcggggg caccatcggc gcccgcctct tccggtccgg ccacgacgtc gtcgtatccg
    16561 cccgagggtc tcatctcgcc gcgctccgct caaccggact gcgtttcgtg acgccgaacg
    16621 gctcggaaac tctgccgatc cccgccgtgg gcggccctgc cgacctggag ctgcgcgagg
    16681 gcgacgtgct gatcgtcgcc accaagacgc aggacacgac cgcggcgctg gaggcgtggg
    16741 cgccccacgc cgacggcctg ccggtggtgt gcgcccagaa cgccgtcgag aacgaacgcc
    16801 tggccctgcg cctgttctcc gacgtctacg ggatgctggt ctggatgccc gccctccacc
    16861 tggagcccgg cacgatcgtc gcctacggca ccccgaagtc cggcatgctc cccctcggac
    16921 gttatccaca gggtgtggac aaactggccg agacgatcgc cgccgacctc gaccgcagcg
    16981 gcttcgcctc gtgggccgac cccgcgatca tgcgctggaa gtacggcaaa ctcctcggca
    17041 acctcggcaa cgccgtcgag gcgctggccg gcccgggtcc cgccggtcgc gacctcgccc
    17101 ggcgcgcccg cgaggagggc ctcgcggcgc tgaccgccgc cggcgtcgac gtgaccaccc
    17161 cggcggagga gcgcgaccgg cgaggcgacc tggtcgagca cggcgagatc gcgggcgtcc
    17221 cccggccggg cggctcgtcg tggcagagcc tggccaaggg cagcggcacg atcgaggccg
    17281 actacctcaa cggtgagatc gtcctgctcg gccggctgca cggcgtcccg accccggtga
    17341 acgccgtgct ccagcgtgag gccaaccggg ccgcgcggga gcggcgggcc cccggatcga
    17401 tcgatgcggc cgcgctgact gaactggttc agtcatgaaa cgtacatagg tcagcgcagg
    17461 tcagagcgtc gggccagacg ggattcttgg gccgcaggcg aaccggttct tagcatccgg
    17521 cccgtgaaga cgtcgaagat gagcgccctc gtggcggctc tggtgctgct cgccgcgttc
    17581 ctcgtcacgc ggcccgccga ggcggccacg gtgcggatca tgccgctggg cgactcgatc
    17641 accggctctc ccggctgctg gcgcgccctg ctgtggcagc gcctccagca gaccggccac
    17701 accgacgtcg acatggtcgg cacactcggc ccgcagggct gcgggttcgc ctacgacggc
    17761 gagaacgagg gccacggcgg cttcctcgtg accaacgtcg cggcccagaa ccagctcgtc
    17821 ggctggctga acgcgaccag ccccgacatc gtgatgatgc acttcggcac caacgacgtc
    17881 tggagcaacc gccccaccca gcagatcctc gacgcctact cgaccctggt cacccagatg
    17941 cgggccaaga accccgccat gaagatcctg gtcgccaaga tcatcccgat gaacccgccg
    18001 acgtgcggcg agtgcgcggc caggaccgtc gccctcaaca acgcgatccc ggcctgggcg
    18061 gcggcccgca cgacggccca gtccccgatc gtcgtcgtcg accagtggac cggcttcagc
    18121 accgcgaccg acacctacga cggcgtccac ccgaacgcgt cgggcgacca gaagatgtcc
    18181 aacgcctggt acccggccct caccgccgcc atcaacggca ccaccccctc cccgtcgccc
    18241 accccctccc cgtcgcccag cccctcaccg tcgccctctc cctcgccttc gcccagcccg
    18301 tcgccgtcgc cgagcccctc ccccagcccg tcgccctcac cccagccggg tggctgcacc
    18361 gcggcctaca agccaggcac ccagtggggc ggcgggttcc aggccgaggt ggtcgtcacg
    18421 gccgggagcg cggcgatcag cgcgtggacg gtccgctgga ccttcgcgaa cggccagcag
    18481 atcacccagc tctggaacgg ctcccacacc cagtcgggcg gccaggtgac ggtgcggaac
    18541 gccgtctaca acggcaacct ggcggcaggc gccgccacca ccttcggctt cctcgcctcg
    18601 tggaacggcg ccaaccccgc tcccaccctc gcctgcacct ctgggtgacc cgagactcgg
    18661 ccgatcgcac cacctgacct aggcggtcgg ccgaaccacg cgaggccggc ctgacagcgg
    18721 ccccgcgaac cttggagccg tggccacccc aggccacggc tccaaggcgt tcccggcctc
    18781 gcgatgacgc ccagcctcgc tcactcctcg gcaggtgcgt ctgtccggat gtgtgccgcg
    18841 aagaacccca tgaccgcgtc ggtcagttcg gccggcttct tctccggggc gaagtggtcg
    18901 agccccggga aggtcgccgt ctcggcgcgg gggatcgtct ccgccagccg gggcagggcg
    18961 gcggtctgcg cgctctggcc atgcatgatc aggaccgggg cctcgacggt gcggtagtcg
    19021 gccagatgcg ggtcgagcct ccccacctcg gcgtgttcgc cgatcgtctg gggcatgagg
    19081 gccagcttcc gcgccctctc cgcacggggc atcgcgaacc gcaggatcac cgtgaggagc
    19141 caccggggta cccgtcccgt ctgctcgggg ttgacgcctc ggatgaaggt cagaaacgcc
    19201 gcctcgttcc tcccttcggc cacctcgcgc cgggcgcgct cgatccagcc gaccgggatc
    19261 gaccctccgg ccgacacccc cggctcgtag acggcgaccg cgtcgtaggc ggggttcccg
    19321 cacgccgccc gcagcgccac cagcccgccg aagctgtgcc cgaagatcag ccgcgccccc
    19381 gtcctcgccc gcaccgcctc gacgtcctca cactcgcgcg cgatgccgta gcggccgccc
    19441 tgcggtccgc tgcgcccacg gccgcgccgc tgcacgacgt gcacggtgtg ccgccccgcc
    19501 aggagcgcgg cgaaggcggc gaagtcgtcc gccacggcga gcgcgccggg gacgacgatg
    19561 acgtggggcc cgtgtcccac ggtcagatat tcgatcggcg tgccatccgc cgacgtcacc
    19621 agttcagtca tgcatacaac gtacgcacaa ccatcccgat acggtcatac agctagtaca
    19681 gtacgtcgac cgcactagta cacctggagt ccgatgaccg accggccgct ctacctgcgc
    19741 atcgccgacg agatcgccgc ggacatccgc tccggacggc tgccggaagg ccggcccgcc
    19801 ccgtcgaccc ggcagatcgt ccgggatcgg ggcgtcgcta tggccaccgc gaccaaagtg
    19861 atcggcaccc tccgcgacca gggcctggtc gagaccgtcc ccggccgcgg caccgtcgtg
    19921 cggcggcgcg gcgccgctcc acgcccgtca cggtcgaggc tgtcggccgc cgagatcgtc
    19981 gaggccgcgg tcgagatcgc cgacgccgag ggactggcgc tggtgacgat gcggagggtg
    20041 gccgtctcgc tgggggcgtc cacgatggcg ctctaccgcc atgtccccaa ccgcaatgac
    20101 ctcaccctcc gcatggccga ccacgtcttc accggagcgc ggctccccga catccgtctg
    20161 gcggactggc gtcgccgcct ggaggtggcg gcccggctgt tctgggcggt cttctcccgc
    20221 catccctggg ccgccgagat cttctcgctg agccgccccc agctcctgcc caacgtgctg
    20281 ccgatcgccg agtggtcgtt cgccacgctg cacgcgatgg ggttctccgc ccacgacatg
    20341 ctgtgcaccc atatcaacct gttcggccag gtccgcggca tggccctggt ccgcctggcg
    20401 gaggcgcgcg ccgaggagga cacggggatg tcggccgacg actggatgcg cgtccggggc
    20461 ggcgacctgg gccgctgggc gagcgatcat ccgggcgtgg gccatgtcgt gcaagaggag
    20521 ttcgacttcg acctcgacac gatcttcgag ttcggcctcc agcgcctcct cgacggcgtg
    20581 gcggcccatc accgcgcgct cgggctctag ggctggaagc ggtagcccat ccccggttcg
    20641 gtcaccaggt ggatcgggtg ggccgggtcg ctctccagct tcctgcggag ctgggcgaag
    20701 tactgccgca ggtagtgggt ctccttgaga taggcggggc cccagacctc ggtcaggagc
    20761 tggcgctgcg agatgagttt gcccgggttt cggaccagga tctccagcag gtgccactcg
    20821 gtgggcgtga gccgcacacc gccgctgatg gtcttgtcgg acaggtcgac cacgtgatcg
    20881 ccgatcttca ccgtcaccgg ttcgccgccg gaggaggcgg tgcggcgggt gaccgcgcgg
    20941 atgcgggcca ggagttcgtc gatgccgaag ggcttggtga cgtagtcgtc ggcgccggcg
    21001 tcgagcgcgc cgaccttgtc ggtgctgccc gcccggccgg agagcacgat gatcggcacc
    21061 ttggtccagc cgcgcagccc gtggatgacc tccaccccgt cgaggtcggg caggcccagg
    21121 tcgagcacga ccaggtccgg gtgccagtcg gcggccaggc gcagcgcggc ggcgccgtcg
    21181 ggagccacgg cgacgtcgta ttcgcgggcc gccaggttga tccgcagcgc gcgcagcagc
    21241 tgaggctcat cgtcgacaac gaggatccgc gtcatgaatg cgaggctacg ccggtcttgg
    21301 gcagagatat cccgctaggg tgctgatcgc gtatctgagg aggaattcat gagcgaatac
    21361 gctcccacct tcgccctcgt cgacgccgac ggggacggcc tcatctcggc cgaagagctg
    21421 acccgcctgg cggatctgct cggccagccg ctcggtgagg cgggcgccgc cgcggtgatc
    21481 gccaaggtcg acggcga
//
