LOCUS       NZ_BBXD01000032        21984 bp    DNA     linear   CON 08-AUG-2024
DEFINITION  Herbidospora mongoliensis strain NBRC 105882, whole genome shotgun
            sequence.
ACCESSION   NZ_BBXD01000032
VERSION     NZ_BBXD01000032.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Herbidospora mongoliensis
  ORGANISM  Herbidospora mongoliensis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Herbidospora.
REFERENCE   1
  AUTHORS   Komaki,H., Ichikawa,N., Oguchi,A., Hamada,M., Tamura,T. and
            Fujita,N.
  TITLE     Genome-based analysis of non-ribosomal peptide synthetase and type-I
            polyketide synthase gene clusters in all type strains of the genus
            Herbidospora
  JOURNAL   BMC Res Notes 8, 548 (2015)
   PUBMED   26452464
  REMARK    DOI:10.1186/s13104-015-1526-9 Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43462)
  AUTHORS   Hosoyama,A., Oguchi,A., Ichikawa,N., Kimura,A., Ohshita,R. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 62x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001570545.1-RS_2024_08_08
            Annotation Date                   :: 08/08/2024 02:40:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,280
            CDSs (total)                      :: 8,202
            Genes (coding)                    :: 8,113
            CDSs (with protein)               :: 8,113
            Genes (RNA)                       :: 78
            rRNAs                             :: 4, 6, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 4, 5 (5S, 16S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 21 of 89
            Pseudo Genes (incomplete)         :: 71 of 89
            Pseudo Genes (internal stop)      :: 4 of 89
            Pseudo Genes (multiple problems)  :: 7 of 89
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:23:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 21478
            Orig. end                         :: 43462
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBXD01000032.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21984
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..21984
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21984
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[20000:>21984](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..>21984
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     misc_feature    70..83
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    175..190
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.02"
                     /tool="antismash"
     gene            499..2043
                     /locus_tag="AW272_RS39430"
     CDS             499..2043
                     /NRPS_PKS="Domain: Aminotran_3 (26-424). E-value: 4.9e-57.
                     Score: 185.4. Matches aSDomain:
                     nrpspksdomains_AW272_RS39430_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017627464.1"
                     /locus_tag="AW272_RS39430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_066376267.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.8e-54, bitscore:
                     176.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVDAEHDLAEPHLRQVLMSAGLDVEYVRAEGDILYQRSADGTER
                     PVLDLVGGYGSLLFGHNHPEIVAHAKALLDARTPVLAQFSVQSVASEVAAALNRIMRRE
                     LGTDEPFFAIFASTGAEGIEAAMKHAELDRVLRIADALAEIEQHIDGALARFGDDIEVT
                     ETVARIRRVNAELAARPPLFAALEGGFHGKLVGSLQLTHNPGVRTPFGALAAQARFVSP
                     DRSGSLKPLVDEAASARLLDLVVEDGLVRTVERPFPLFCAFFLEPIQGEGGITPLTSEF
                     VEEIQEACAEIGCPVIVDEIQSGMGRTGDFLAGTAVGLRGDYYVIGKGLGGGIGKCAAL
                     LVRQSRYRPQFELLHSSTFAKDGFSSGIALKTLELLEADDGHVYRRAAELGERLLSVMR
                     ALRDDFPGVVKDVRGRGLMLGLDFHDQSGAAAPSIGAASASGFFGYFLSGFLLREHAMR
                     VFPTASAVNTLRFEPSIGLTADHVDRLETALRDLCTVLRDQEDGRFAPSPTSSGTA"
     aSDomain        577..1770
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AW272_RS39430_Aminotran_3.1"
                     /evalue="4.90E-57"
                     /label="AW272_RS39430_Aminotran_3.1"
                     /locus_tag="AW272_RS39430"
                     /protein_end="424"
                     /protein_start="26"
                     /score="185.4"
                     /tool="antismash"
                     /translation="YVRAEGDILYQRSADGTERPVLDLVGGYGSLLFGHNHPEIVAHAK
                     ALLDARTPVLAQFSVQSVASEVAAALNRIMRRELGTDEPFFAIFASTGAEGIEAAMKHA
                     ELDRVLRIADALAEIEQHIDGALARFGDDIEVTETVARIRRVNAELAARPPLFAALEGG
                     FHGKLVGSLQLTHNPGVRTPFGALAAQARFVSPDRSGSLKPLVDEAASARLLDLVVEDG
                     LVRTVERPFPLFCAFFLEPIQGEGGITPLTSEFVEEIQEACAEIGCPVIVDEIQSGMGR
                     TGDFLAGTAVGLRGDYYVIGKGLGGGIGKCAALLVRQSRYRPQFELLHSSTFAKDGFSS
                     GIALKTLELLEADDGHVYRRAAELGERLLSVMRALRDDFPGVVKDVRGRGLMLGLDFH"
     gene            complement(2098..2784)
                     /locus_tag="AW272_RS39435"
     CDS             complement(2098..2784)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025126.4"
                     /locus_tag="AW272_RS39435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_157519319.1"
                     /transl_table=11
                     /translation="MIHVRGEWAAGLVGPDVWQTCRELIPAGSVFAFLAEHRQALFAAE
                     MFADMYRPCRHALTSAGHRTVIKPAPLRPAVPGGFNLDDFAIDTTAGTVTCPAGHQVPL
                     SAPSGRHLQRKALFSGLCAGCPLRPRCTTAKAGRILTLAPTTTSLPPPRRHRSGLAGGL
                     PALEAPVERAIAWIVARGNRRLRYVGTIKNNAWPHTRAAALNLRTLINLGLTRTSASWT
                     LASTTI"
     misc_feature    complement(2230..2232)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2296..2298)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2838..3575)
                     /locus_tag="AW272_RS39440"
     CDS             complement(2838..3575)
                     /NRPS_PKS="Domain: Thioesterase (18-235). E-value: 5.9e-53.
                     Score: 172.6. Matches aSDomain:
                     nrpspksdomains_AW272_RS39440_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017623634.1"
                     /locus_tag="AW272_RS39440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioesterase II family protein"
                     /protein_id="WP_066376280.1"
                     /sec_met_domain="Thioesterase (E-value: 3.8e-52, bitscore:
                     169.0, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.5e-13, bitscore:
                     43.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRRWFRGFGLEAAADAPDLICFPHAGGAATAYRLLAQLLTPGVR
                     VLGVQYPGRQDRRAEPAVESVTGLADAVADLLPPDPGRPYALFGHSMGAAVAYETARRI
                     AERGGPEPERLFLSGRAAPAADPRHSDVLTGDAAIVARIRRLGGTASGVLDDPELLEMV
                     LPALRADHAALRTYHWKPGPLLEVPFTVLGGDADPMVTPSEAVQWLEHSGLPGEVKIFK
                     GGHFYLETELAEVAGLLSAALRR"
     aSDomain        complement(2871..3521)
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AW272_RS39440_Thioesterase.1"
                     /evalue="5.90E-53"
                     /label="AW272_RS39440_Thioesterase.1"
                     /locus_tag="AW272_RS39440"
                     /protein_end="235"
                     /protein_start="18"
                     /score="172.6"
                     /tool="antismash"
                     /translation="DLICFPHAGGAATAYRLLAQLLTPGVRVLGVQYPGRQDRRAEPAV
                     ESVTGLADAVADLLPPDPGRPYALFGHSMGAAVAYETARRIAERGGPEPERLFLSGRAA
                     PAADPRHSDVLTGDAAIVARIRRLGGTASGVLDDPELLEMVLPALRADHAALRTYHWKP
                     GPLLEVPFTVLGGDADPMVTPSEAVQWLEHSGLPGEVKIFKGGHFYLETELAEV"
     CDS_motif       complement(3267..3335)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39440_0001"
                     /evalue="6.30E-10"
                     /label="NRPS-te1"
                     /locus_tag="AW272_RS39440"
                     /protein_end="103"
                     /protein_start="80"
                     /score="31.4"
                     /tool="antismash"
                     /translation="PGRPYALFGHSMGAAVAYETARR"
     misc_feature    3741..3755
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            3793..4404
                     /locus_tag="AW272_RS39445"
     CDS             3793..4404
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292626.1"
                     /locus_tag="AW272_RS39445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DsbA family protein"
                     /protein_id="WP_157519323.1"
                     /transl_table=11
                     /translation="MESNRIPVDFWFDAMCPWSWIASRWLLEVEHIRPVDLRWHVMSWS
                     ILQQGVDLLPEHVEIVRQGWGPARVAIAVEQQHGNAELGALYSAYGKRYQHQGRTLNRA
                     AIVDSLAEIGLPVDLAEAAEDKDYDDALLASHMDGMDRVGYEVGTPILAINGVAYFGPV
                     MSPIPRGEAAGRLFDGLALVSGTKGFFELKRSRTRAPIIR"
     gene            complement(4464..6731)
                     /locus_tag="AW272_RS39450"
     CDS             complement(4464..6731)
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF042649.2"
                     /locus_tag="AW272_RS39450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="xanthine dehydrogenase family protein
                     molybdopterin-binding subunit"
                     /protein_id="WP_066376269.1"
                     /transl_table=11
                     /translation="MTKILGTPVVRTDAVAKVTGQAAYVADHTPAGTLHAALATGTISR
                     GRITAIDAGGAERLPGVRLVLTHRNLGDAVKEGQFLTPVLGGQFQTSFNPLGSDEIRYS
                     GQIVALAVADTPEIAEEAARLIRVEYEEVPAVIALADLAPDAPGRIDLHGLQTGDTATA
                     LAESHVVVDREYATSVNHHNPIEPFHAAALWQDGRLEIRVPSQWVTGERFALAGALGVT
                     EEDVRVVSPYVGGGFGSKGATLWHTVLTAEAARRLDAPVKLSITRRQMFTIASFRPESR
                     HWVRLAATSDGRFTAYEHEVLTQTSRSDVLALPGTDNTARLYAFPNIHTRESTIGVDVN
                     TPGFMRGPLEYPELFALESAVDELAMVLDVDPMELRLRNEPAKEPVEGLRYSSRSLQEC
                     YRRGAELFGWHRRRARPGSMRDSDGTLIGWGCASASYPVFEGGVCDSRITVGSDGRALV
                     EVASQDIGTGTYTLLAQIAAETSGLALADVRVALGDSDLPRGLATAASSTTGTVGAAVH
                     ENARSVREQLLAAAAVRFGRPRAVEDLTISDGVVRAGDGLRITVAELVADLPRGVLAVE
                     IRHTPPRLPAEMAQTTLRDGTFNITGPARPDHVAFSYGANFAEVRVDPVTRQVRMGRMV
                     GVFAVGRVLNPRIAHGLLAGGMIWGAGHALMEKTVMDRDRARFVNTDLAGYHIAANADI
                     SDVIVETVDEHDDLVNVLGAKGGVGEMGIVAMPAAIANAVFHATGVRVRRLPILVDDLL
                     IG"
     gene            complement(6728..7720)
                     /locus_tag="AW272_RS39455"
     CDS             complement(6728..7720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547428.1"
                     /locus_tag="AW272_RS39455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_066376271.1"
                     /transl_table=11
                     /translation="MRPFTYARVSSLNEAARESSRPGAMVLAGGTTLVDLMRGNVLAPD
                     HLVDIRRLPGLDGVEETGTWLRIGALSRMADVATDERVRARYPAIAESLRLAASQQVRN
                     MATIGGNLLQRTRCPYYRDGDSPCNKREPGTGCSALAGPDRDSAVLGGSESCVAVYPGD
                     LGVSLVAFEASVELLSAGGPKTLPFAELHRDVADEPERETTLSPGDIVTAVTIPNSALV
                     RGSAYVKVADRARYAFAIASAAAGLTIEDGVVTAARVGLGGVATRPWRSHEAEAELVGR
                     PLTADTAKAAGRAAFAAARAGRDNAVKITLGPRVVEQACLRAGQGGERA"
     gene            complement(7725..8243)
                     /locus_tag="AW272_RS39460"
     CDS             complement(7725..8243)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017584514.1"
                     /locus_tag="AW272_RS39460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_083959167.1"
                     /transl_table=11
                     /translation="MTTPDPERTSHPPLEAPDTFQVNLTVNGTARTVDVDPRTTLLTLL
                     RERFDLTGTKAGCHQGTCGACTVHVDGRRALSCLILTVSADDAEIRTIEDLAEPDGTLH
                     PMQRAFVEFDALQCGFCTPGQIMSAEACVREGNAESDDDVREYMSGNLCRCSAYPNIVR
                     AVRSVAESR"
     gene            complement(8262..8393)
                     /locus_tag="AW272_RS45845"
     CDS             complement(8262..8393)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AW272_RS45845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275527348.1"
                     /transl_table=11
                     /translation="MFSGVMTAADAGRTWNQPVAVDHGDLHDRQRRPEALAASRFHG"
     gene            complement(8426..9877)
                     /locus_tag="AW272_RS39465"
     CDS             complement(8426..9877)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="AW272_RS39465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_066376273.1"
                     /transl_table=11
                     /translation="MAQSSEKNPSTTGPSKPPPSRWAALGLLCAAMFMVALDGQIVILA
                     MPSIQADLGFSVSSLQWVLSGYLLSFGGLLLLAGRAADLLGHRRLFVIGVVLFLASSVL
                     CGAAWSQETLIIARLVQGASAAIMSPTALALLMTTFDEGPDRNRALAIWTGTGAFGATA
                     ALLIGGVVTDLLGWEWIFYLNIPVAAVMLALVPVLLRESHTPATERSFDLGGAITSTGA
                     AVVLIYAVVEAPNIGWGHSRTIGLLAAAAVLVALFVVIEKKSVAPLVPFRIFKSSSLVS
                     GNLMMIVVGMLLLGFNVLVSLYAQQVLLFTPVIFGLGTLAYALMDILSANVAGVIVGKI
                     GYRVVALAGMVLFGIGSLLMTAISADGSYFSDLFVGLLVFGSAVGTCFVAVSIAALTGV
                     PDEDAGLASGINNAAFWIGGALGSAVVSTVAVIYTKGTGPAALTEGFQAGFWTCVALAA
                     VGAVIALILLLLPQPAEEEALPAAH"
     gene            9993..10976
                     /locus_tag="AW272_RS39470"
     CDS             9993..10976
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013152308.1"
                     /locus_tag="AW272_RS39470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase subunit sigma-70"
                     /protein_id="WP_066376288.1"
                     /transl_table=11
                     /translation="MTGVVADRGNFGQLADRFRPELLAHCCRILGSAHEAEDLVQETYL
                     RAWRSLDEFEGRASLRNWLYRIATNTCLNAIEARSRRPLPTGLGGPADPAADQHGQESA
                     WLEPIARVLFGSEPADPATVIETRTSVRLALTVAWRRLTPRQRAVLLLCEVLGWRAGEV
                     AELLGTSSAAVYSMLQRARAQLTKAAGPADEVDEPDDPHERDLLDRYVAAFEHADLPAL
                     MNLLTSDAVCEVPPEPIGLAGREAIARFLATECPAFGTCQMVRTTHQGKPAFATYLRGE
                     DGTHRAYSVEVLTISSQGIARIVSHQRPEMFHNLGLPLVRHSPSAR"
     misc_feature    complement(10033..10047)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     gene            10986..11579
                     /locus_tag="AW272_RS39475"
     CDS             10986..11579
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03086.1"
                     /locus_tag="AW272_RS39475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR03086 family metal-binding protein"
                     /protein_id="WP_083959168.1"
                     /transl_table=11
                     /translation="MTMPYVLSAPTEGIGLLKQALDYALATGQHITADVLTAPTPCDRW
                     DLATLLLHLNESLDALQEGLREGCVGVMPTGPPAPDADLLFGFRSRACRLLHTCAMVCA
                     PDQVRVGDWQLSLSTLAGIGAIEVAVHGWDVGRACGHPYPIPANLAEELLLLAPLVIND
                     ATRHSLFAPPVSTPSTVPSDRLLALLGRDAAGRP"
     gene            complement(11821..13638)
                     /locus_tag="AW272_RS43685"
     CDS             complement(11821..13638)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="AW272_RS43685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_369408852.1"
                     /transl_table=11
                     /translation="MDALWSFDDTPITARKILQNAIWGLRRVFAAHGGEGPDLLLTQAP
                     GYRLQVAPERVDLHLFHQWTATGRAELANGAPEAAASQFRAALALWRGPALADLEETGR
                     AWPEVITAQNARLDVLEDYFEAELACGRPHAILGELEAMVDNEPPRERACGQLMHALYY
                     CGRQADALNVYQRMRIRLVEEFGLQPSPELQLLQHAILTQDLGLGPQPPVALRETRRPA
                     LSSGATTAHRVQPPGVRDTAPPVSEQAARQPRQVGLPVPVSPTETVVASERRQMSVVLV
                     QTWLCLDLDSAGATEIDQVMEEAAVVIRERAGNFGGFVMTSMGSLSMLVFSARNDQDTH
                     AERAVRAAAVIRDSLGALAAPGTHTSRFVRGLSVHAAVATGEAFARPGPNDGPPVVNGA
                     LLDYCRSLLSAAPADDIHVCDRTRLATGPSICYEQVEHQGGDSPVRWRMCDGHGCYDHE
                     LELLQQLLERAHRSSAPHLVTVLGGSGIARSRLFIEFQRRVREQLPEPASYVCVSAAPS
                     GERTLMPYLAVPPEGNPDHLLVVIADDLHHADDRSLDLMENLTDTLGPVPALIIVGAKP
                     ELLDRRPGWAGGKRHAITITLDPLMATVA"
     misc_feature    complement(13734..13748)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.29"
                     /tool="antismash"
     misc_feature    13927..13942
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.14"
                     /tool="antismash"
     misc_feature    complement(13958..13972)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.82"
                     /tool="antismash"
     misc_feature    complement(14071..14085)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.03"
                     /tool="antismash"
     gene            14574..15959
                     /locus_tag="AW272_RS39485"
     CDS             14574..15959
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657692.1"
                     /locus_tag="AW272_RS39485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_066376298.1"
                     /transl_table=11
                     /translation="MSGRITDRALVLGGSIAGLFAARVLSETYTEVIVVDRDALTGVEQ
                     ARQGVPQGRQVHGLLARGRQAIEELFPGITGDLVAAGAGSGDVAGNLRWYFNGVPLARD
                     ESGMVAVTVSRPMLEFHVRQKVQDIPNVRFLERHDILGVTATADAGRITGARVREPDTE
                     IERELTADLVVDATGRGSRTPVWLTELGYQRVAEDRLKIGIGYTTRHYRIRTDPFGRDI
                     SINVIASPTLPRGAICGRHGNYIELTAYGVLGDVPPSDPEGFAAFLASLAVPDIAHAAS
                     LSEPVDDPVSYQFPANLRRRYERLDRFPDGFVLLGDSVCSFNPTYAQGMTIAALGALAL
                     RSHLRSGPPRSMDFLRELARDVLDGPWDLMTTGDLTFPGVPGERTFKVRMAHGLVAKVL
                     EAATRDGKVASAYLRVAGLLDPPEALMKPAMLLRILRGSLGRRSVPVPAPRDGRERPAR
                     ELA"
     gene            complement(16085..16501)
                     /locus_tag="AW272_RS39490"
     CDS             complement(16085..16501)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025887.4"
                     /locus_tag="AW272_RS39490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_066376300.1"
                     /transl_table=11
                     /translation="MTANLKIDLDNLDLTDDPETQNEVFMLAFNSGDGNVFNSLYREDS
                     ISNLSGQPLRGEERKRFIVEMIGKKPRLKAVLKSSYVAGDISLVKVVFDLEVTGEDGEP
                     VVLHGSCTDVMRREANGKWMMAIDRPIADAMPQA"
     misc_feature    16469..16483
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            16715..18115
                     /locus_tag="AW272_RS39495"
     CDS             16715..18115
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013739.4"
                     /locus_tag="AW272_RS39495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_083959170.1"
                     /sec_met_domain="DAO (E-value: 2e-09, bitscore: 28.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEETVENLSRRGLLAAGVAAGVPLGQTGVAAASGGGEPDAIVIG
                     AGYAGVTAARELAARGLRPLVLEARDRIGGRTWTDTFAGLPVERGGTWVHWSQPHVWAE
                     MMRYGIGVVEDPAPDRAILPTPDGPRSFPLDEAFGHLGELLVRFFDGAATLFDRPFDPL
                     YNADAVRPADRISLRARLDAMRLPARDESWMSGVTSAYSGGRSTRGAYTQMARWWSLAG
                     GGFDKWNAATGHYRIESGTIGLLTAILADASAELRLSTPVASVVDDGRRVHVTTRSGRR
                     FSAPVAVVALPANVWHTIRFDPGLPAAHTAATREGIGVPNGTKIWIHVRGDVGRFFAQD
                     AEGGPISALIPYRETGDGLLVVGFSYHPTFDGSDLAQVRAAVRRQEPKAEVTAIKAQNW
                     ARDEFSLGGAACQTPGQLTRLHAALQRPSGRLAFATSDIAAGWNGYIDGAIESGIRAGR
                     QAADAAGR"
     gene            complement(18179..19354)
                     /locus_tag="AW272_RS39500"
     CDS             complement(18179..19354)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019640.4"
                     /locus_tag="AW272_RS39500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_066376278.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.6e-07, bitscore:
                     23.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.8e-08, bitscore:
                     26.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVNEQAAAVIQAVRDVVPTLRENGLAAEENRWIPEENIELLDKA
                     GVFRAAVPTRFGGLDLSLEEQYDILVQVARGCGSTGWVALAWVSTAWLITQYPDRAQEE
                     IFTSDSVRISGGFSPTGTLTPVEDGYLLNGTWRFNSGCRGAQWDLLGALLELPDGSHQE
                     LYAVVPMSVLSIADDWYVSAAAATGSSTTSAKDVFVPAHRVMDAAEALEGLTGERSNTG
                     ATGRNYPLIGYIMASSVASYIGMARAAFELFVERVPGRPIAYTSWEDQAAHPLTQLRVA
                     TSANKIEAADALVRRWITALQAHADAGTQPTLEERAEGRGRCGYAIQLAKESVEDLQSI
                     SSGSAIMRSAPFQRFFRDIEGLALHGMMTPNPNLEVHGRVVLGLEPDTYLL"
     gene            complement(19404..19799)
                     /locus_tag="AW272_RS39505"
     CDS             complement(19404..19799)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025887.4"
                     /locus_tag="AW272_RS39505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_066376279.1"
                     /transl_table=11
                     /translation="MSTIEDFQLTDDAQLQTQLYVRAFNSGDFETLERLYTEEAIAVWE
                     PGRPLSGQARRDHIAETLRAKPRMTATDRHRYETGDATLLVVDWQVEIAGADGEIEVHT
                     GVGLDVLRRGEDGKWRYAIDDPYGESE"
     misc_feature    19900..19914
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     misc_feature    20001..20015
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            20001..>21984
                     /locus_tag="AW272_RS39510"
     CDS             20001..>21984
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (15-430). E-value:
                     7.6e-165. Score: 540.8. Matches aSDomain:
                     nrpspksdomains_AW272_RS39510_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012337.4"
                     /locus_tag="AW272_RS39510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I polyketide synthase"
                     /protein_id="WP_157519321.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 7.5e-75, bitscore:
                     243.0, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 4.8e-165, bitscore:
                     540.8, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.7e-47, bitscore: 153.5,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIVDPAAGADRDRAVAIVGISCRLPGADSPALFWELLRTGRSAI
                     GDAPADRWDRAVAPAARRGGFLDAVGDFDADFFGISPREAAGMDPQQRLVLELVWEALE
                     DGRIVPASLRDGDTSMYVGTLRDDYSGLVQRQGLSEITQHTITGVNRGVIANRVSYFLG
                     LRGASLTVDTAQSSSLVALHLAAESLRAGDAGLSIVAGVNLNLTAESAVTAERFGGLSP
                     DGLCFTFDARANGFVRGEGGVVVVLKRLADALADGDRVHAVLRGGAVNNDGATPGLTVP
                     GRDAQEQVIRQAYDHAGVAPERVQYVELHGTGTRVGDPIEAAALGAALGAARDPGVPLL
                     VGSAKTNVGHLEGAAGLVGLLKVVLSIRNRELPPSLNFETPNPAIALDLLNLSVQTELA
                     AWPRPDEPLVAGVSSFGMGGTNCHVVVTEAPAVEAAGERARPGLLPWLLSGRDEAALRA
                     QAAALTDLTADPLDVGASLLTRSVFGYRAVVVGADRAELVSGLEALGAGLPGVVSGVAG
                     DGRLGWVFSGQGAQRVGMGAGLAGVFPVFAEVFGEVCGRFEGLAEVIASGEGLERTGWA
                     QPGLFAVEVALARLLESWGVRPDVVVGHSIGEVAAAHVAGVLSLSDAVRLVEARGRLMQ
                     ALPEGGAMWALQASEEEVVPHLFGRV"
     aSDomain        20046..21290
                     /ASF="found active site cysteine: False, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AW272_RS39510_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="7.60E-165"
                     /label="AW272_RS39510_PKS_KS.1"
                     /locus_tag="AW272_RS39510"
                     /protein_end="430"
                     /protein_start="15"
                     /score="540.8"
                     /tool="antismash"
                     /translation="VAIVGISCRLPGADSPALFWELLRTGRSAIGDAPADRWDRAVAPA
                     ARRGGFLDAVGDFDADFFGISPREAAGMDPQQRLVLELVWEALEDGRIVPASLRDGDTS
                     MYVGTLRDDYSGLVQRQGLSEITQHTITGVNRGVIANRVSYFLGLRGASLTVDTAQSSS
                     LVALHLAAESLRAGDAGLSIVAGVNLNLTAESAVTAERFGGLSPDGLCFTFDARANGFV
                     RGEGGVVVVLKRLADALADGDRVHAVLRGGAVNNDGATPGLTVPGRDAQEQVIRQAYDH
                     AGVAPERVQYVELHGTGTRVGDPIEAAALGAALGAARDPGVPLLVGSAKTNVGHLEGAA
                     GLVGLLKVVLSIRNRELPPSLNFETPNPAIALDLLNLSVQTELAAWPRPDEPLVAGVSS
                     FGMGGTNCHVVVTEAP"
     CDS_motif       20496..20543
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0001"
                     /evalue="2.70E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="AW272_RS39510"
                     /protein_end="181"
                     /protein_start="165"
                     /score="13.4"
                     /tool="antismash"
                     /translation="GASLTVDTAQSSSLVA"
     CDS_motif       20589..20645
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0002"
                     /evalue="8.80E+01"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="AW272_RS39510"
                     /protein_end="215"
                     /protein_start="196"
                     /score="-3.5"
                     /tool="antismash"
                     /translation="SIVAGVNLNLTAESAVTAE"
     CDS_motif       20685..20723
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0003"
                     /evalue="7.20E-05"
                     /label="PKSI-KS_m4"
                     /locus_tag="AW272_RS39510"
                     /protein_end="241"
                     /protein_start="228"
                     /score="15.6"
                     /tool="antismash"
                     /translation="FDARANGFVRGEG"
     CDS_motif       20916..20963
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0004"
                     /evalue="8.10E-05"
                     /label="PKSI-KS_m5"
                     /locus_tag="AW272_RS39510"
                     /protein_end="321"
                     /protein_start="305"
                     /score="14.5"
                     /tool="antismash"
                     /translation="YVELHGTGTRVGDPIE"
     CDS_motif       21024..21068
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0005"
                     /evalue="1.20E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="AW272_RS39510"
                     /protein_end="356"
                     /protein_start="341"
                     /score="11.4"
                     /tool="antismash"
                     /translation="GSAKTNVGHLEGAAG"
     CDS_motif       21567..21617
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0006"
                     /evalue="5.40E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="AW272_RS39510"
                     /protein_end="539"
                     /protein_start="522"
                     /score="15.7"
                     /tool="antismash"
                     /translation="WVFSGQGAQRVGMGAGL"
     CDS_motif       21711..21776
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0007"
                     /evalue="6.30E-05"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="AW272_RS39510"
                     /protein_end="592"
                     /protein_start="570"
                     /score="16.0"
                     /tool="antismash"
                     /translation="ERTGWAQPGLFAVEVALARLLE"
     CDS_motif       21783..21905
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AW272_RS39510_0008"
                     /evalue="7.20E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="AW272_RS39510"
                     /protein_end="635"
                     /protein_start="594"
                     /score="72.9"
                     /tool="antismash"
                     /translation="GVRPDVVVGHSIGEVAAAHVAGVLSLSDAVRLVEARGRLMQ"
ORIGIN
        1 tgctggcggg cgtcgagaat ggtcacggcg aaccgtcgcg ccgcggtgag cgcctcgtgc
       61 atcacggcgt tgtgggagat cgagcacagg atcgacggag gcgtcagcga caccgaggtg
      121 aatgcgttgg cggtcatcgc gtgcgggtcc ggcccgccga ccgtgatgac gaccacgccg
      181 gtcgcgaacc gcgacatcac atcacgtagt tcgaagggtt gcacacccgg gacactgatc
      241 ttcgtgggag tggacttcac ggcatccctc tcagcgaatc ggcacggcgg cgaatagcgg
      301 gcgaccggac agccgcctat cgaccaatca accagcccgc accggacgtc ggcccattgg
      361 gcggtaattc gtcactcact ctcgaaattt cccgctccga attaccgcgc cgctaccggc
      421 aggagaatgc ctttcttgac cgcgaagtta aaatgcgttc tgttgatgac aatttccctg
      481 tcagaaaagg atgggccgat gcgcgtagac gctgaacacg acctcgccga gccgcacctg
      541 cgtcaggtgc tcatgtcggc cgggctcgac gtggagtatg tccgggccga gggcgacatt
      601 ctctaccagc gcagcgccga cggcacggag cggccggtac tcgacctcgt cggcggttac
      661 gggtccctgc tgttcggaca caaccacccc gagatcgtgg cgcacgccaa ggccctgctg
      721 gacgcgcgga ctccggtgct cgcccagttc tccgtgcagt ccgtcgccag tgaggtcgcg
      781 gccgcgctca accggatcat gcggcgggag ctcggcaccg acgagccgtt cttcgccatc
      841 ttcgccagca ccggcgcgga gggcatcgag gcggcgatga agcacgccga actcgaccgc
      901 gtcctgcgga tcgccgacgc gctggccgag atcgaacagc acatcgacgg cgcgctggcc
      961 cgtttcggcg acgacatcga agtgaccgag accgtcgccc ggatccgccg ggtgaacgcc
     1021 gagctggccg cccggccgcc gctgttcgcc gccttggagg gcggcttcca cggcaagctc
     1081 gtcggcagcc tccagctcac ccacaatccg ggcgtgcgga ccccgttcgg cgcgctcgcc
     1141 gcccaggccc gtttcgtgtc accggatcgc tcgggcagcc tcaagcccct ggtggacgag
     1201 gcggcctcgg cgcggctgct ggacctggtc gtcgaggacg gcctcgtccg gacggtcgaa
     1261 cgccccttcc cgctgttctg cgccttcttc ctcgaaccga tccaaggtga gggcggcatc
     1321 acccccctga cgtcggagtt cgtcgaggag attcaggagg cttgcgcgga gatcggctgt
     1381 cccgtcatcg tcgacgagat ccagagcggc atgggccgga cgggcgactt cctcgccggg
     1441 accgccgtcg gtctgcgcgg cgactactac gtcatcggca agggcctcgg cggcggcatc
     1501 ggcaagtgcg ccgctctgct ggtccgccag tcccgctacc gcccgcagtt cgaattgctg
     1561 cacagctcca ccttcgccaa ggacggattc tccagcggca tcgccctgaa gacgctggaa
     1621 ctgctcgaag ccgacgacgg ccacgtgtac cggcgggccg ccgaactggg tgagcggctg
     1681 ctgtcggtga tgcgtgccct gcgcgacgac ttccccggcg tcgtcaagga cgtccgaggg
     1741 cgagggctga tgctcggcct ggacttccac gaccagtccg gtgccgcggc cccctcgatc
     1801 ggcgcggcct cggcgtccgg gttcttcggc tacttcctgt ccgggttcct gctgcgagag
     1861 cacgcgatgc gcgtcttccc gaccgccagc gccgtgaaca ccctgcgctt cgaaccctcg
     1921 atcggcctca ccgccgacca cgtcgaccgc ctggagacgg cgctgcgcga cctgtgcacc
     1981 gtcctgcgcg accaggagga cggccgtttc gcgccgtccc ccacctcatc cggtacggcc
     2041 tagaagacca ctgaagatct tgttcgcgtg cggcgacgtt gcgcggcccg cgatttctca
     2101 gatggtcgtg gaggccagtg tccaggacgc gctcgtgcgg gtgagtccga ggttgatcag
     2161 ggttcgcagg ttgagcgcgg cggcgcgggt gtggggccag gcgttgttct tgatggtgcc
     2221 gacataccgt aatcggcggt tgccccgggc gacgatccag gcgatggcgc gttcgaccgg
     2281 ggcctccagc gccggtaatc ctcccgccag gcccgatcgg tggcggcgtg gcggcggcaa
     2341 gctcgtcgtg gtgggggcga gggtgaggat gcgcccggct ttggcagtgg tgcagcgcgg
     2401 gcgcagcggg cagccggcgc acaggccgga gaacaacgcc ttgcgctgca ggtggcggcc
     2461 tgacggcgct gacagcggga cttggtgtcc ggccgggcag gtcacggtcc cggcggtggt
     2521 gtcgatggcg aagtcgtcca ggttgaaccc gccgggcacg gccggccgca gcggcgcggg
     2581 tttgatcact gtgcgatgcc ctgccgaggt cagcgcgtgg cggcaaggcc gatacatgtc
     2641 cgcgaacatc tccgccgcaa acagcgcctg acgatgctcg gccaggaacg cgaacacgct
     2701 ccccgccggg atcaactccc ggcaggtctg ccacacgtcc ggtccgacga gccctgcggc
     2761 ccactcaccc cgcacgtgaa tcacttgggc ctcattccgg aaagaacggg gccagaacac
     2821 aggatttcag cggtcttcta gcggcgcagc gccgccgaca gcagtcccgc cacctcggcc
     2881 agttccgtct ccagatagaa atggccgccc ttgaagatct tcacctctcc cgggagaccg
     2941 gagtgctcca gccattggac agcctcggac ggcgtgacca tcgggtcggc gtcgccgccg
     3001 agcacggtga acggcacctc cagcagcggc ccgggcttcc agtgataggt ccgcagcgcg
     3061 gcatggtcgg cacgcaacgc cggcaggacc atctccagca gctccgggtc gtccagcacc
     3121 ccgctcgccg tcccgccgag ccgccggatc cgcgcaacga tcgccgcgtc cccggtcagc
     3181 acgtcactgt ggcggggatc ggccgccggc gcggcgcgcc cggacaggaa cagccgctca
     3241 ggctcgggcc cgccgcgctc ggcgatccgg cgggccgtct cgtaggcgac ggccgcgccc
     3301 atgctgtgcc cgaacagcgc gtacggccgg cccgggtccg gcggcagcag atcggccacc
     3361 gcgtcggcga gaccggtgac gctctccacg gcgggctccg cacgccggtc ctgccggcct
     3421 ggatactgca cgcccagcac ccgcactccg ggcgtcagca gctgggcgag cagccgatag
     3481 gcggtggcgg ccccgcccgc gtgcggaaag cagatcaggt ccggggcgtc cgcggcggcc
     3541 tccaggccga agccgcggaa ccatctccgg cgcatctcgt ccacatcgtc cccattgtct
     3601 atgtcgtgcc ggtccggtca ccgccagcct tgccgctggt ccggcaccac cggtcacgac
     3661 ccggtaatcg ccgcgccatc agcggaatcc cgtgcggcgg ttccctcctc gcctcccgat
     3721 ggaatcggag ccgacgggcg gtcttaattt cagaggtgtt caacatgcgt caaggaagga
     3781 ccgaccgtga cgattgagtc aaacaggatc cctgtggact tctggttcga tgccatgtgc
     3841 ccgtggtcgt ggatcgcgtc gcgctggctg ctggaggtgg agcacatccg cccggtcgac
     3901 ctgcgctggc acgtcatgag ctggtccatc ctgcagcagg gcgtcgacct gctgccggag
     3961 catgtggaga tcgtccggca ggggtgggga ccggcgcggg tcgccatcgc ggtcgaacag
     4021 cagcacggca acgccgaact cggcgccctg tactcggcct acggcaagcg ctaccagcac
     4081 cagggccgca ccctgaaccg cgcggccatc gtggactccc tcgccgagat cggcctgccc
     4141 gtcgacctcg ccgaggcggc tgaggacaag gactacgacg acgccctcct ggcatcgcac
     4201 atggacggga tggaccgggt cggctacgag gttggcaccc ccatcctggc gatcaacggc
     4261 gtcgcctact tcgggccggt catgtcgccg atcccgcgcg gtgaggcggc gggcaggctc
     4321 ttcgacggcc tggcgctcgt gtcgggcacc aagggcttct tcgagctgaa gcgcagccgg
     4381 acccgggctc cgatcatccg ttagcggccg gatccggccg ggacacggtg ggtggtgccc
     4441 ggtgcccggg caccacccac ggatcagccg atcagcaggt cgtcgaccag gatcggcagc
     4501 cttctgaccc ggacaccggt ggcgtggaac accgcgttgg cgatggcggc gggcatggcg
     4561 acgatgccca tctcgccgac accgcctttc gcacccagga cgttgaccag gtcgtcgtgc
     4621 tcgtcgaccg tctccacgat cacgtcggag atgtcggcgt tcgccgcgat gtggtacccg
     4681 gcgaggtcgg tgttgacgaa ccgtgcgcgg tcacgatcca tgacggtctt ctccatcagc
     4741 gcatggcccg cgccccagat catcccgccc gccagcaggc cgtgcgcgat cctcgggttc
     4801 agcacccggc cgaccgcgaa gacgccgacc atgcggccca tccgcacctg ccgcgtgacc
     4861 ggatcgacgc ggacctccgc gaagttggcc ccgtagctga aggccacgtg gtccggccgc
     4921 gccggaccgg tgatgttgaa ggtgccgtcc cgcagggtgg tctgcgccat ctcggcgggc
     4981 agccggggcg gcgtgtgccg gatctcgacc gccaggacgc cgcgcggcag gtcggcgacc
     5041 aactcggcga cggtgatccg gaggccgtcg cccgcccgta caacgccgtc cgagatggtc
     5101 aggtcctcca ccgcgcgcgg ccgtccgaac cgcacggccg cggccgccag caactgttcc
     5161 cgtacggacc gggcgttctc gtggacggcc gcgccgaccg tcccggtcgt cgacgacgcc
     5221 gccgtggcga ggccgcgcgg caggtcgctg tcccccaacg ccacccgcac gtcggccagc
     5281 gcgagccccg acgtctcggc ggcgatctgg gcgagcaacg tgtaggtccc ggttccgatg
     5341 tcctggctcg cgacctccac cagggcccgg ccgtccgagc ccacggtgat cctgctgtcg
     5401 cacacgccac cctcgaacac ggggtagctc gcgctcgcgc agccccagcc gatgagcgtt
     5461 ccgtcggagt cccgcatcga accgggacgg gccctgcgcc ggtgccagcc gaacagctcc
     5521 gcgccccggc gatagcactc ctgcagcgac cgactgctgt accggagccc ctccacgggc
     5581 tccttcgccg gctcgttgcg cagtcgtagc tccatcggat ccacgtcgag caccatggcc
     5641 agttcgtcga cggcgctctc caacgcgaac agttcggggt actccaacgg cccccgcatg
     5701 aagcccggag tgttcacgtc gaccccgatg gtgctctcac gcgtgtggat gttggggaag
     5761 gcgtacagcc gcgcggtgtt gtcggtgccg gggagggcca ggacgtcgct gcgcgaggtc
     5821 tgggtgagga cctcgtgctc gtaggcggtg aaccggccgt cggaggtcgc ggccagccgc
     5881 acccaatgcc gtgactcggg ccggaacgag gcgatcgtga acatctgccg gcgggtgatc
     5941 gacagcttca ccggggcgtc cagccgccgc gcggcctcgg cggtcagcac tgtgtgccac
     6001 agcgtcgcac ccttggaccc gaacccgccg cccacgtacg ggctgacgac gcgcacgtcc
     6061 tcctcggtga caccgagggc gccggccagc gcgaaccgct cgccggtaac ccactggctg
     6121 gggacgcgga tctccaggcg gccgtcctgc cacagcgccg cggcgtggaa cggctcgatc
     6181 gggttgtgat ggttgacgga ggtggcgtac tcacggtcga ccacgacgtg cgactcggcg
     6241 agcgccgtcg cggtgtcgcc ggtctgcagg ccgtgcaggt cgatccgccc cggtgcgtcg
     6301 ggggcgaggt cggccagcgc gatcacggcg ggcacctcct cgtactcgac ccggatcagg
     6361 cgggccgcct cctcggcgat ctccggggtg tcggccacgg cgagcgccac gatctggccc
     6421 gagtagcgga tctcgtcgga gccgagcggg ttgaagctcg tctggaactg gccgcccagc
     6481 accggggtga ggaactggcc ctccttcacg gcgtcgccga ggttgcggtg ggtgaggacc
     6541 aggcggaccc ccggcagccg ttcggccccg ccggcgtcga tggcggtgat acgccctcgg
     6601 gaaatcgttc ccgtcgccag tgcggcgtgc agcgtcccgg ctggcgtgtg gtcggcgacg
     6661 tacgcggcct ggccggtgac cttggccacc gcgtcggtcc ggaccaccgg ggttcccagg
     6721 atcttcgtca tgctcgttcc cctccctgtc ccgcgcgcag acacgcctgc tcgaccaccc
     6781 gaggccccag cgtgatcttc acagcgttgt cgcggcccgc tcgggccgcg gcgaaggcgg
     6841 cccggcccgc ggccttggcg gtgtcggcgg tcaacggacg cccgacgagt tccgcctcgg
     6901 cctcgtgact gcgccacggc cgggtcgcca ccccgcccaa acccacccgc gccgctgtga
     6961 cgacgccgtc ctcgatcgtg agcccggccg ccgccgacgc gatggcgaac gcgtaacggg
     7021 cccggtcggc gaccttgaca taggcggagc cacgcaccag ggcgctgttc gggatggtca
     7081 cggccgtgac gatgtcaccg ggcgacagcg tcgtctcccg ctccggctcg tcggcgacgt
     7141 cccggtgcag ttcggcgaag ggcagggtct tgggcccccc ggccgacagc agttccacgg
     7201 acgcctcgaa cgccaccagc gagacgccga ggtctccggg gtagaccgcg acacacgatt
     7261 ccgacccgcc cagcacggca ctgtcgcggt cggggccggc cagcgcgctg cacccggttc
     7321 ccggctcacg cttgttgcag ggcgagtcgc cgtcgcggta gtaggggcag cgggtgcgtt
     7381 gcaggaggtt cccgccgatg gtggccatgt tgcgcacctg ctgggaggcg gccagccgca
     7441 ggctctcggc gatcgcgggg tagcgcgccc gcacccgctc gtcggtggcc acgtcggcca
     7501 tccgggacaa cgcgccaatc cgcagccacg tgccggtctc ctccacgccg tccaggcccg
     7561 gcaaccgcct gatgtcgacc agatgatcag gggccaggac gttgccccgc atcaggtcta
     7621 ccagcgtggt gccgcccgcc agcaccatcg cccccggtct ggagctctcc cgcgccgcct
     7681 cgttcaggct ggaaacgcgc gcgtacgtga aaggcctcat gtcctcaccg gctctcggcg
     7741 acggaccgta cggcccgcac gatgttcgga tacgcggagc atcggcacag gttgccgctc
     7801 atgtattcgc gcacgtcgtc gtcggactcg gcattgccct cgcggacgca cgcctcggcc
     7861 gacatgatct gccccggcgt gcagaagccg cactgcagcg cgtcgaactc cacgaacgcc
     7921 cgctgcatcg gatgcagggt gccgtcgggc tcggccaggt cctcgatcgt ccggatctcg
     7981 gcgtcgtcgg cactgaccgt gaggatcagg cacgacaggg ctcgccgccc gtcgacgtgc
     8041 accgtgcagg cgccgcaggt gccctggtgg caaccggcct tggtgccggt caggtcgaac
     8101 cgctcacgca gcagcgtgag cagtgtggtg cgcggatcca catcgactgt tcgcgcggtt
     8161 ccgttcaccg tcaggttcac ctggaaggtg tcgggcgctt ccagcggtgg gtgggatgtg
     8221 cgctcgggat cgggtgtggt catgggctcc tccaggtgaa ctcatccgtg gaatcgcgac
     8281 gccgccagcg cctccgggcg gcgctggcgg tcgtggaggt cgccgtgatc gacggcgacc
     8341 ggctggttcc atgttctccc tgcgtcggcg gccgtcatga ctccggagaa catgcggtta
     8401 ccagccgatg ggggccgatg gagggtcagt gagcggcggg gagcgcctcc tcttcggccg
     8461 gctggggcag gagcagcagg atcagcgcga tgacggcgcc gacggcggct agggccacgc
     8521 aggtccagaa cccggcctgg aacccctcgg tgagggcggc ggggccggtg cccttggtgt
     8581 agatgaccgc cacggtggag acgacggcgc tgccgagcgc tccgccgatc cagaacgcgg
     8641 cgttgttgat gcccgaggcc agcccggcgt cctcgtccgg gacaccggtg agggcggcga
     8701 tggagaccgc gacgaaacag gtgccgactg cggacccgaa gaccagcagc ccgacgaaca
     8761 ggtcgctgaa gtagctgccg tccgccgaga tcgccgtcat gagcagcgag ccgatgccga
     8821 acagcaccat gcccgccagc gcgacgaccc ggtacccgat cttgccgacg atcacaccgg
     8881 cgacgttggc cgacaggatg tccatcaggg cgtacgccag cgtgcccagg ccgaagatga
     8941 ccggggtgaa cagcagcacc tgctgggcgt agagggagac caggacgttg aagccgagga
     9001 gcagcatgcc gaccacgatc atcatcaggt tcccgctgac cagcgagctc gacttgaaga
     9061 tccggaacgg caccagcggt gccaccgact tcttctcgat gacgacgaac agcgcgacca
     9121 gtacggcggc ggcagccagc aggccgatgg tccggctgtg gccccagccg atgttgggcg
     9181 cctccacgac ggcgtagatg agcaccacgg ccgcgccggt gctggtgatc gcgccgccga
     9241 ggtcgaagga gcgttcggtg gcgggcgtgt ggctctcccg cagcaggacc gggaccaggg
     9301 ccagcatgac ggcggcgacc gggatgttca ggtagaagat ccattcccag ccgagcaggt
     9361 cggtgaccac gccgccgatc agcagcgcgg cggtcgcgcc gaaggcgccg gtgcccgtcc
     9421 agatggccag tgcccggttg cggtcgggcc cttcgtcgaa ggtggtcatc agcagggcca
     9481 gcgcggtggg cgacatgatc gcggccgacg cgccctgcac gaggcgggcg atgatcaggg
     9541 tctcctggga ccaggcggcg ccgcacagca ccgaggaggc caggaacagg acgacgccga
     9601 tgacgaagag cctgcggtgg cccagcaggt cggcggcccg gccggccagc agcagcagac
     9661 cgccgaagct gagcaggtat ccgctcagca cccattggag gctggagacg ctgaaaccga
     9721 ggtcggcctg gatggagggc atcgccagga tgacgatctg gccgtccagg gcgaccatga
     9781 acatggcggc gcacagcagg ccgagcgccg cccagcgtga gggtggaggc ttcgaagggc
     9841 cggttgtcga ggggtttttc tctgatgact gagccatgtt gatgaagaca gacggccgat
     9901 cgcattttcg tcgggtgtcc cccgatggat tccgggccgc ccgtctgtcc tcattgaaga
     9961 gggcgtcagc aagggaaaat gggagtgtga tgatgacggg tgtggtggcg gatcgaggga
    10021 acttcggcca actggccgat cggttccggc cggagttgct ggcgcactgc tgccggatcc
    10081 tcggctccgc gcacgaggcc gaggatctgg tccaggagac ctacctgcgg gcgtggcggt
    10141 cgctcgacga gttcgagggc cgcgcctcgc tgcgcaactg gctgtaccgg atcgcgacca
    10201 acacctgcct gaacgcgatc gaggcgcgca gccggcggcc gttgccgacc gggctgggcg
    10261 gccccgcgga tccggccgcc gaccagcacg gccaggagtc ggcctggctg gagccgatcg
    10321 cccgcgtgct gttcggcagc gagccggccg accccgcgac ggtgatcgag acgcggacgt
    10381 cggtccggct ggcgctgacc gttgcgtggc ggcgtctgac gccgcgtcag cgtgccgtcc
    10441 tgctgctgtg cgaggtgctg gggtggcggg ccggagaggt cgcggaactg ctcggcacca
    10501 gtagcgcggc ggtctacagc atgttgcagc gggccagggc gcagctcacc aaggcggccg
    10561 gcccggccga cgaggtggac gagcccgatg acccgcacga acgtgacctg ctcgaccgtt
    10621 acgtggccgc gttcgaacac gccgacctgc cggcgttgat gaacctgctc accagcgacg
    10681 ccgtctgcga ggtgccgccg gagccgatcg gtctggcggg ccgcgaagcc atcgcccgtt
    10741 tcctggcgac cgaatgcccc gctttcggca cctgccagat ggttcgcacc actcaccagg
    10801 ggaagccggc cttcgccacc tacctgcggg gtgaggacgg cacccaccgc gcgtactcgg
    10861 tcgaggtcct cacgatctcg tcgcagggca tcgcccggat cgtgtcgcac cagcgcccgg
    10921 agatgttcca caatctgggc ttgccgctgg tgcgccattc cccgtcggcc cgttagggct
    10981 cggttatgac gatgccctac gtgctgagcg caccgaccga aggaatcggc ctgctcaaac
    11041 aggcgctgga ctatgcgctg gcgacgggtc agcacatcac cgccgatgtg ctgaccgcgc
    11101 cgacgccctg cgaccggtgg gatctcgcca cgctgctgct gcacctcaac gagtcgctgg
    11161 acgccctgca ggagggcctt agggaggggt gcgtgggcgt catgccgacc ggcccgcccg
    11221 ctcccgacgc cgacctgctc ttcgggttcc gcagtcgcgc ctgccgcctg ctgcacacgt
    11281 gcgcgatggt ctgcgctccc gaccaggtgc gggtcggaga ctggcagctg tcgctctcga
    11341 cgctggcggg cataggggcg atcgaggtcg cggtgcacgg ctgggacgtg gggcgcgcct
    11401 gcggtcaccc gtatcccatc ccggcgaacc tggccgagga gctgctgctc ctggctccgc
    11461 tggtcatcaa cgacgcgacc cgccactcgc tgttcgcgcc gcccgtctcg actccgtcca
    11521 ccgttccgtc cgaccggctg ctggcattgc tgggccgtga cgcggcggga aggccgtgac
    11581 cggcgcctgc accgatcagg ccatgtggac caggctcctg cggttgcaga ccgtggtgga
    11641 acgtcgtcac cgaggcgggc agggaacgct acctcctggt cagtgagacc tactccgatg
    11701 tcctcgcctg cgcactggac accttggacg cggatccgca gttcgcgggc ctggtccggg
    11761 ccctgcgtcc aggtcgaccg tccgacgggg acggccgacc tggagagcag atgacccttc
    11821 tcaggccacg gtggccatca gcgggtcgag ggtgatcgtg atcgcgtgcc gctttccgcc
    11881 cgcccacccg gggcgccggt ccagcagttc cggcttggcg ccgacgatga tgagcgccgg
    11941 gacggggccg agggtgtccg tcaggttctc catcaggtcc agcgaccggt catctgcgtg
    12001 gtgcagatcg tccgcgatca cgacgagcag gtggtcggga ttcccttccg gcggtacggc
    12061 caggtacggc atcagggtcc gctcgccgct gggggccgcg ctcacgcaca cgtacgaggc
    12121 gggttcgggc aactgttcgc gcaccctgcg ctggaactcg atgaaaagcc gggacctggc
    12181 gatgcctgac ccgccgagca ccgtgacgag atgcggggcg ctgctgcgat gggcgcgctc
    12241 caggagttgc tgcagcagtt cgagttcgtg gtcgtagcag ccgtggccgt cgcacatccg
    12301 ccagcgcacg ggagagtcgc cgccctgatg ttcgacctgt tcgtaacaga tgcttggccc
    12361 ggtggccagc cgggtccggt cgcacacgtg gatgtcgtcg gcgggggccg ccgacagcag
    12421 cgaacggcag tagtccagca gggcgccgtt gacgacgggc gggccgtcat tgggcccggg
    12481 gcgggcgaaa gcctcaccgg tggccacggc ggcgtgcacc gacagcccgc gcacgaagcg
    12541 cgaggtgtgg gtgcccggag cggccagcgc gccgagcgag tcgcggatca cggcggcggc
    12601 gcgcacggcc cgctcggcgt gggtgtcctg gtcgttgcgg gcgctgaaga ccagcatcga
    12661 caacgaaccc atcgaggtca tgacgaaacc gccgaaattc cctgccctct cccggatcac
    12721 caccgccgcc tcctccatga cctggtcgat ctcggtggcg ccggcgctgt cgaggtccag
    12781 acagagccag gtctggacga ggacgacgct catctggcgt cgctcggagg ccacgaccgt
    12841 ttcggtggga gacaccggca ccgggagacc tacctggcga ggctgccgcg cagcctgttc
    12901 ggagacaggg ggagcggtgt cccgtactcc aggcggctga actcgatggg ccgtcgttgc
    12961 gccgctgctg agagcaggac gccgggtctc ccgcagcgcg accggaggct gcggacccag
    13021 cccgaggtcc tgggtgagaa tggcgtgctg gagcaactgg agttcggggc tgggctggag
    13081 gccgaactcc tccacgagcc tgatccgcat ccgctggtag acgttcagcg cgtccgcctg
    13141 gcgtccgcag tagtacagag cgtgcatgag ctggccgcag gcgcgttccc gcggtggctc
    13201 attgtcgacc atggcctcca gttcgccgag gatggcatga gggcggccac aggccagttc
    13261 cgcctcgaag tagtcctcca gcacgtccag ccgggcgttc tgcgcggtga tcacttccgg
    13321 ccaggcgcgg ccggtctcct ccagatcggc caacgccggg ccccgccaga gcgccagggc
    13381 ggcgcggaac tgggaggcgg ccgcctcggg cgcgccgttg gccagctccg cgcgcccggt
    13441 ggcggtccac tggtggaaca aatggaggtc gacccgctca ggcgcgacct gcagccgata
    13501 accgggcgcc tgggtgagca ggagatcggg gccttcaccg ccgtgcgccg cgaacacccg
    13561 gcgcagcccc cagatcgcgt tctgcagtat tttgcgtgcg gtgatgggag tgtcgtcgaa
    13621 actccacaat gcgtccatca actggtctgt ggacgcaacc tgattcgcct tcaaaagcag
    13681 cagcccgagg gctgcccgct gctttgcgcc acctagtgga accggttgtt cgccggaaat
    13741 gacttcgagc gggccgagca cacgaaacca catagcactc caggtatgct tgacaagcag
    13801 gacgggaatg cgctaagggg gaattgtggg gcgggattgt cgccccttgg cctcatagtc
    13861 aggctcgttg taaaccccag cctcatggta gaaatcaagt ggttggtttg tccatctagt
    13921 tgtcggtgtg accgatctca tataaccgta aatccgataa aagtgatgtt aagttcgcag
    13981 ttcgcagcct cagtggccgc attaggccat ctttgggccc ccggtactcc cgtgccacgt
    14041 atcgatcttt gggtcgttgc cgctggtggt aggaccggag ggcccggttt cggtgtcgtc
    14101 gccgggaccg gttgagggtg cggcgatggc acgatccatt cgcgctgaca gcggcggatc
    14161 tcgttggaag agaccgcgat taaggggccg gccggatcgg ccggtttcgg ctataagcat
    14221 ggcgcgggtg ggcggtcgca tccacgatcc ggggcgcgca ggggccgtgt taacgagcac
    14281 tccgcccatc cgccacgcgc ccatccgcca cgcggcgatg caccggtaaa tgcgactgct
    14341 ggttactccg gcgaatattt cggtgacgat acgttcggat cctgatgcgg taacccactg
    14401 gttcccggcg cttacgtaat cgcggttaca gggcgattac cgcgcccttg acgcttgctt
    14461 cccacgcttg tctagggtcg gttctggcat ggtcgtggcc ggttcggaat gcttttcgga
    14521 ctcgcgcctc caacgcctca cccaggagat ccgaaacgag ggaggtggcc gtcatgagtg
    14581 gtcgaatcac cgatcgtgcc ctggtgctcg gtggcagcat cgccggtctg ttcgccgcgc
    14641 gggtcctgtc cgagacgtac acggaagtca tcgtcgtcga ccgcgatgcg ctgaccgggg
    14701 tagagcaggc ccggcagggc gttccgcagg gccgccaggt gcacggcctg ctggcccggg
    14761 gcaggcaggc catcgaggaa ctgttccccg gcatcaccgg cgacctcgtc gcggccggcg
    14821 cgggaagcgg tgacgtggcc ggcaacctgc gctggtactt caacggggtc cccttggcgc
    14881 gggacgagtc gggcatggtc gcggtgaccg tgagccgtcc gatgctggag ttccacgtcc
    14941 gccagaaggt ccaggacatc cccaacgtac ggttcctgga gcggcacgac atcctgggcg
    15001 tgaccgccac cgccgacgca ggccggatca ccggggcacg cgtgcgcgag ccggacacgg
    15061 agatcgagcg ggagctgacc gcggacctgg tggtggacgc gaccggccgg ggttcgcgca
    15121 ccccggtgtg gctcaccgaa ctcggctacc agcgggtcgc cgaggatcgc ttgaagatcg
    15181 gcatcgggta caccacccgc cactaccgga tccgtaccga cccgttcggc cgtgacatct
    15241 ccatcaatgt catcgcctcg ccgacgctgc cccgcggggc gatctgcggc aggcacggaa
    15301 actacatcga gctgaccgcc tacggagtgc tgggtgacgt gccgccctcc gacccagaag
    15361 ggttcgccgc cttcctcgcc tcgctcgcgg tgcccgacat cgcgcacgcc gcgagtctca
    15421 gcgaaccggt cgacgatccg gtgtcctacc agtttccggc caatctgcga cggcggtacg
    15481 agcggctgga ccggttcccc gacggcttcg tcctcctggg cgactcggtg tgcagtttca
    15541 accccaccta cgcccagggc atgaccatcg cggcgctggg cgcgctggcg ctgcgctcgc
    15601 atctgcgctc gggtccgccg cgttcgatgg acttcctgcg cgagctggcc cgcgacgtcc
    15661 tggacgggcc gtgggacctg atgaccaccg gcgacctcac ctttcccggt gtgccggggg
    15721 agcggacgtt caaggtgcgg atggcgcacg gtctggtggc gaaggtgctg gaggccgcga
    15781 ccagggacgg caaggtcgcc tccgcctatc tgcgcgtcgc gggcctgctg gacccgcccg
    15841 aggcgttgat gaagcccgcg atgctcctgc ggatcctgcg cggctcgctg ggccggcgtt
    15901 cggttcccgt accggcgccg cgcgacggcc gggagaggcc cgcccgcgaa ctcgcctgaa
    15961 cgtgctgctc tccgccccgg tccgctctgg ccatccccca tgagagcgga ccggggcggg
    16021 cgcgcgcgaa ggcccctgcc ggtcgagatg gcggcagggg ccgggacgtg cgggtgtgcg
    16081 ttggtcaggc ctgcggcatg gcgtcggcga tgggccggtc gatcgccatc atccacttgc
    16141 cgttcgcctc acggcgcatg acgtcggtgc aggagccgtg cagcacgacc ggctcgccgt
    16201 cctcgccggt gacctccagg tcgaacacca ctttcaccag cgagatgtca ccggcgacgt
    16261 aggagctctt cagcacggcc ttcagacgcg gcttcttgcc gatcatctcg acgatgaaac
    16321 gcttgcgctc ctcgccgcgc agtggctggc ccgacaggtt ggagatcgag tcctcccggt
    16381 agagcgaatt gaacacgttt ccatcgccgg aattgaaggc gagcatgaag acttcgttct
    16441 gggtctccgg atcgtcggtc aggtccaaat tatccaggtc gattttgaga ttcgccgtca
    16501 tcagatggct gacctccatt tctcggaaca cccggcggtg ttcgctctct cagtctaccg
    16561 atcggaaaac cgccgcatta attgctcggt aactcaccgt tcatgcccgg gccagaccgg
    16621 tcggtgacca gagatcggca ttatttctcg cacctgaaag aaattcgccg cgcgcgagga
    16681 tttcgcgggc agtgacggaa gggaagcgca catcatgggc gaagagaccg ttgaaaacct
    16741 gtcgcgtcgc ggactgctgg ccgccggggt ggcggcgggt gtgccgctcg gtcagaccgg
    16801 cgtcgcggcg gcgagcggcg gaggcgaacc ggacgcgatc gtcatcgggg cgggctacgc
    16861 gggtgtcacg gcggcgcgcg agctggcggc gcgcgggctg cgccccctgg tgctggaggc
    16921 ccgcgaccgg atcggcggcc gcacctggac cgacacgttc gcggggctgc cggtcgagcg
    16981 gggcggcacg tgggtgcact ggagtcagcc ccacgtatgg gccgagatga tgcggtacgg
    17041 catcggcgtc gtcgaggatc ccgccccgga ccgggcgatc ctccccaccc cggacggacc
    17101 gcggtccttc ccgctcgacg aggcgttcgg gcatctgggg gagctgctcg tacggttctt
    17161 cgacggcgcg gccaccctgt tcgaccgccc cttcgacccg ctgtacaacg ccgacgcggt
    17221 acggccggcc gaccggatct ccctgcgcgc ccggcttgac gcgatgcgcc tgccggcccg
    17281 cgacgagagc tggatgtcgg gggtgacctc ggcgtactcg ggcgggagga gcacccgcgg
    17341 cgcctacacg cagatggccc gctggtggtc gctggccggt gggggattcg acaagtggaa
    17401 cgccgcgacc ggtcactacc ggatcgaatc gggcactatc gggctgctga ccgccatcct
    17461 cgccgacgcc agcgccgagc tgcgcctcag cacgcctgtc gcctcggtcg tcgacgacgg
    17521 ccgccgcgtg cacgtcacca cccggtcagg ccggcggttc tccgcgcccg tggcggtggt
    17581 cgcgctcccc gcgaacgtgt ggcacaccat caggttcgac ccgggcctgc ctgccgccca
    17641 caccgccgcc acccgggagg gcatcggagt gcccaacggc accaagatct ggatccacgt
    17701 gcgtggtgac gtgggccgct tcttcgcaca ggacgccgag ggcggcccga tctccgcact
    17761 gatcccttac cgggagaccg gggacggcct gctggtcgtc gggttcagct accaccccac
    17821 gttcgacggc tccgacctcg cccaggtccg cgccgcggtg cgccggcagg agccgaaggc
    17881 cgaggtgacc gcgatcaagg cgcagaactg ggcgcgcgac gagttctcgc tcggcggcgc
    17941 cgcctgccag acccccggcc agctcacccg gctgcacgcg gccctccagc ggcccagcgg
    18001 acgtctcgca ttcgccacca gcgacatcgc cgcggggtgg aacggctaca tcgacggcgc
    18061 catcgagtcc ggcatccgcg ccggccgcca ggcagccgac gcggccggcc ggtaggttcc
    18121 ccggcgaaac ggcccgtccg gcatcacgct ggacgggccg cttcccgcgg gcctggggtc
    18181 agagcaggta ggtgtcgggt tcgagcccga ggacgaccct gccgtgcacc tccaggttcg
    18241 ggttcggcgt catcatgccg tgcagcgcca ggccctcgat gtcacggaag aaccgctgga
    18301 acggagccga ccgcatgatc gcggaaccgc tgctgatgga ctgcaggtcc tcgaccgact
    18361 ccttggccag ctggatcgcg tacccgcagc ggcctcggcc ctcggcccgt tcctccagcg
    18421 tcggctgggt gcccgcgtcg gcgtgcgcct ggagcgcggt gatccagcgg cgcaccagcg
    18481 cgtccgccgc ctcgatcttg ttggcggacg tggcgacccg caactgcgtg agcgggtgcg
    18541 cggcctggtc ctcccacgag gtgtacgcga tcgggcggcc cggcacccgc tcgacgaaca
    18601 actcgaacgc ggcccgcgcc atgccgatgt aggacgccac cgacgaggcc atgatgtacc
    18661 cgatgagcgg atagttgcgg ccggtggcac cggtgttgga ccgctctccg gtcaggccct
    18721 ccagggcctc ggcggcgtcc atcacccggt gcgcgggcac gaacacgtcc ttggcggagg
    18781 tagtggagct gccggtcgcg gcggcggcgg acacgtacca gtcgtcggcg atcgacagca
    18841 ccgacatcgg caccaccgcg tacagctcct ggtgcgagcc gtccggcaac tccagcagcg
    18901 ccccgagcag gtcccactgc gcgccccggc acccggagtt gaaccgccag gtgccattca
    18961 gcagatagcc gtcctccacc ggcgtcagcg tgccggtcgg cgagaacccg ccggagatcc
    19021 gcaccgagtc gctcgtgaag atctcctcct gcgcccggtc gggatactgc gtgatcagcc
    19081 acgcagtcga cacccaggcc agcgcgaccc atccggtcga gccgcagccg cgcgccacct
    19141 ggaccaggat gtcgtactgc tcctccaacg acaggtcgag cccgccgaac cgggtcggga
    19201 ccgcggcccg gaacaccccg gccttgtcca gcagctcgat gttctcctcg gggatccagc
    19261 ggttctcctc tgccgccaga ccgttctcgc gcagtgtcgg caccacgtcc cgcaccgcct
    19321 ggatcacagc ggcggcctgc tcgttcacag ccattcctgc tccctgtcgt cgccctgacc
    19381 ggctggatgg ccggaggtgt gcctcactcg ctctcgccgt acgggtcgtc gatcgcgtac
    19441 cgccacttac cgtcctcgcc acgtcgcagc acgtcgaggc cgacgcccgt gtgcacctcg
    19501 atctcgccgt cggcgccggc gatctcgacc tgccagtcga cgaccagcag cgtggcgtcg
    19561 ccggtctcgt accggtgccg gtccgtggcg gtcatgcgcg gcttggcccg cagcgtctcg
    19621 gcgatgtggt cgcggcgtgc ctgcccactc aagggccggc ccggctccca gaccgcgatg
    19681 gcctcttcgg tgtagagccg ctcgagtgtc tcgaagtcac cggagttgaa ggctcgtacg
    19741 tacaactggg tctgcagttg cgcgtcatcg gtgagttgga aatcctcgat cgtggacatg
    19801 actgctccct gcctcgtcta ggctcggcga cttctgtaat tctccaagct agtcatgcgc
    19861 cctcattacg cgctcatcgc cgggcaattc gccgctggcg gctcagttcg agaacgcgtg
    19921 gttaccggcc cggaattaat gtgcgaggtc gatcgccgct tcaggcgctt tcgattcggg
    19981 gagacgaaag gcgttaagcg atgaccattg ttgatccggc tgccggggcc gaccgggacc
    20041 gggccgtcgc cattgtcggg atctcctgcc ggcttccggg cgccgattcc ccggcacttt
    20101 tctgggaact gctgcgcacc gggaggagcg cgatcgggga cgccccggcc gaccgctggg
    20161 accgggcggt ggcgcccgcc gcccgccggg gcggtttcct cgacgcggtc ggggacttcg
    20221 acgcggactt cttcggtatc tccccgcgcg aggccgccgg catggatccg cagcagcgcc
    20281 tggtgctgga actggtgtgg gaggcgttgg aggacggccg catcgtgccc gcctcgctgc
    20341 gtgacggcga cacctcgatg tacgtcggaa cgctccgcga tgactactcg ggcctggttc
    20401 agcggcaggg tctttcggag atcacccagc acaccatcac cggcgtgaac cggggggtca
    20461 tcgccaaccg ggtctcctat ttcctcgggt tgcgcggtgc cagcctcacc gtggacaccg
    20521 cccagtcgtc gtcactggtc gcgctccatc tggctgccga gtccctccgg gcgggcgacg
    20581 cgggcctgtc gatcgtcgcc ggggtgaacc tcaacctcac cgccgagagc gcggtcaccg
    20641 ccgaacgttt cggcggactg tccccggacg gtctgtgctt caccttcgac gctcgcgcca
    20701 acggtttcgt ccgtggggag ggcggggtgg tcgtggtcct caagcggctg gccgacgcgc
    20761 tcgccgacgg cgaccgtgtc catgccgtac tgcgcggcgg cgcggtcaac aacgacggcg
    20821 ccacccccgg cctcaccgtg ccggggcggg acgcgcagga acaggtgatc cggcaggcct
    20881 acgatcacgc cggcgtcgct ccggagaggg tccagtacgt ggagctgcac ggcacgggca
    20941 ctcgcgtcgg cgaccccatc gaggcggccg cgctgggggc ggcgctcggc gcggcccgcg
    21001 accccggtgt gccgctgctc gtcggatcgg ccaagacgaa cgtcggccat ttggaaggcg
    21061 ccgccggtct ggtcggcctg ctgaaggtcg tgctgagcat caggaaccgg gagttgccgc
    21121 ccagcctgaa cttcgagacg ccgaaccccg ccatcgccct cgacctgctc aacctgagcg
    21181 tgcaaaccga actcgccgcc tggccccgcc cggacgagcc gctggtggcg ggggtcagct
    21241 cgttcggcat gggcggcacc aactgccacg tcgtggtcac cgaagcgcct gccgtcgagg
    21301 ccgctgggga gcgggcgcgc ccgggactcc tgccgtggct gctgtcgggc cgcgacgagg
    21361 cggcgctgag ggcgcaggcg gcggcgttga cggacctcac ggcggatcct ctggacgtcg
    21421 gcgcctcgct gctcacccgg tcggtgttcg ggtatcgcgc ggtggtggtg ggggctgatc
    21481 gtgcggagct ggtgtcgggt ttggaggcgt tgggggccgg tctgccgggt gtggtgtccg
    21541 gtgtggcggg tgatggtcgt ctggggtggg ttttctctgg tcagggtgct cagcgggtgg
    21601 gtatgggggc gggccttgcc ggggtgtttc cggtgttcgc tgaggtgttc ggggaggtgt
    21661 gcggtcggtt cgagggactg gctgaggtga tcgcttcggg tgagggcttg gagcggacgg
    21721 gttgggctca gccgggattg ttcgcggtcg aggtggcgct ggcccggttg ctggagtcgt
    21781 ggggtgtgcg gccggatgtg gtggtcggtc attcgatcgg tgaggtcgct gccgcgcacg
    21841 tcgctggggt gctgtcgctg tctgatgcgg ttcgcctggt ggaggcgcgt ggtcggctga
    21901 tgcaggcgct gccggagggt ggggcgatgt gggcgctgca agcctccgaa gaggaagtcg
    21961 tcccgcatct gttcgggcgg gtgg
//
