LOCUS       NZ_BBXD01000010        23431 bp    DNA     linear   CON 08-AUG-2024
DEFINITION  Herbidospora mongoliensis strain NBRC 105882, whole genome shotgun
            sequence.
ACCESSION   NZ_BBXD01000010
VERSION     NZ_BBXD01000010.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Herbidospora mongoliensis
  ORGANISM  Herbidospora mongoliensis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Herbidospora.
REFERENCE   1
  AUTHORS   Komaki,H., Ichikawa,N., Oguchi,A., Hamada,M., Tamura,T. and
            Fujita,N.
  TITLE     Genome-based analysis of non-ribosomal peptide synthetase and type-I
            polyketide synthase gene clusters in all type strains of the genus
            Herbidospora
  JOURNAL   BMC Res Notes 8, 548 (2015)
   PUBMED   26452464
  REMARK    DOI:10.1186/s13104-015-1526-9 Publication Status: Online-Only
REFERENCE   2  (bases 1 to 663229)
  AUTHORS   Hosoyama,A., Oguchi,A., Ichikawa,N., Kimura,A., Ohshita,R. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 62x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001570545.1-RS_2024_08_08
            Annotation Date                   :: 08/08/2024 02:40:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,280
            CDSs (total)                      :: 8,202
            Genes (coding)                    :: 8,113
            CDSs (with protein)               :: 8,113
            Genes (RNA)                       :: 78
            rRNAs                             :: 4, 6, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 4, 5 (5S, 16S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 21 of 89
            Pseudo Genes (incomplete)         :: 71 of 89
            Pseudo Genes (internal stop)      :: 4 of 89
            Pseudo Genes (multiple problems)  :: 7 of 89
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:23:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 311743
            Orig. end                         :: 335174
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBXD01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23431
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23431
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23431
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13431](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13431
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    285..300
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.64"
                     /tool="antismash"
     misc_feature    745..765
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.26"
                     /tool="antismash"
     misc_feature    complement(1233..1248)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 22.96"
                     /tool="antismash"
     misc_feature    1238..1249
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.78"
                     /tool="antismash"
     misc_feature    complement(1245..1254)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.35"
                     /tool="antismash"
     gene            complement(1337..4594)
                     /locus_tag="AW272_RS10235"
     CDS             complement(1337..4594)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF018884.4"
                     /locus_tag="AW272_RS10235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_157518461.1"
                     /transl_table=11
                     /translation="MRAVLMAGGLMGEMIAAHDWSCSPIGPMAGWPQSLRSAVSLCLVS
                     RFPCFVFWGPEMIQLTNDAFIPVLGSKHPAALGRPAREVWSETWDLVGPMLAGVVADRE
                     SAFFEDLPVVLERGRFAEECYFTFCYSPIITETGEVGGVFATVTETTAEVVGARRTAVQ
                     AELSEHTRTAGSAAEACERAAQVFARHPVDVPFALLYLLEPGSDQTVLVSAAGLVAGDA
                     AAPPVVPLHSGGAWPLGEALGGPVEVGCPADPRLERMARDRFAPPSRALVLPITAADQP
                     AGFLVVGINPGRPLDAAYRTFLNLLTGQVAAAITDASALDAARHRAERLAALDRAKTTF
                     FANVSHELRTPLTLMLGPLEGLLADPATPEREQVEMVHRNALRLLRHVNTLLDFTSAGH
                     ADQLRFEPVDLSAYTAELAALFGPALEHGGVTLVLDCRPLPEPVWVDRPAWDQIVLNLM
                     SNAFKYTLGGRITLGVDAHDGRARLRVTDTGVGISPEELPLIFDRFHRVEDSASRSVEG
                     SGIGLSLVRDLLHRHEGTIEVTSEPGRGSTFTALLPFRATAAAAASNAPVRTREEPEAA
                     VYVSEAFSWVDGADHRDESGGPVEVLVVDDNADMRAHLVRALSPHWRVRAVGDGQAALE
                     SVLRQPPELVLTDVMMPRLDGFGLLKALRRNAATSDIPVVMVSARAGTEAIIEGLDEGA
                     DDYLVKPFTTAELLARVRTHLTTTRQRRAAATRIQLLADITHQLNTSLDPGAIAATLAR
                     HLTPAYGETTSIWLHEKTPDSSRRLLHGTGEAADDRLVLPLIYGGDYIGAVELSGLTAA
                     ARTNLERPFLFQLIDRAALALGNATRFQHEHDTALNLQTAMLTDLPDVPGLAMAALYQP
                     AAAKDLVGGDWYDAFVIPADEGVDVSLAVTIGDITGHDIHAAALMGQVRNMLRQAVIDH
                     PGQGPAAAVTALEYACDNLPITASGTLVQGQLDRDTAGAWTFTWTNAGHPRPLLLHPDG
                     TVDQLLEYGLLIFPKLHPHPRLDHRRALPSGSTLLLYSDGLIDRPGSDVEHDIALAIRL
                     LAEHHDQPLDELLHTLATRIPGPHPTDDIALLAVRIP"
     gene            complement(4833..5327)
                     /locus_tag="AW272_RS10240"
     CDS             complement(4833..5327)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AW272_RS10240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_066363058.1"
                     /transl_table=11
                     /translation="MSPFKKLTRVAAVTAAAVFALGTPAHAADEAGKLTARLVITGGGS
                     DCRIFTTGKVGMTNAQAQYLVDNGATARVEVWADDPIYDNRVYKGPKATLIPVSDKNGG
                     GLLIVSDLHLSCVSYLDEDDKPPFDYGDEIYTKIIFEAPGYSRMTKSSNVIHRNFGFGE
                     P"
     gene            5544..6251
                     /locus_tag="AW272_RS10245"
     CDS             5544..6251
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AW272_RS10245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="CAP domain-containing protein"
                     /protein_id="WP_066363060.1"
                     /transl_table=11
                     /translation="MKRLALLGSAALVAAAVTVPASPALAAAPLAGAATCADVDLVFQQ
                     KSAFPDTTRGRYDHMMQGSRIEKSVQCLVNAERAARGLQPVKRYIALRGTTVALSSATA
                     KQVAAAVRIRWWGTVAQVGNCTPLKSDPSRCDVHVNPETGTDPGARAKAAGYCKRGTSW
                     AVGENAYLGWGSPSVTPRAAVTWWMGSPPHRATILTPGYTELYTKAAYGSADPSVSATP
                     AVTYVQMFGRCSS"
     gene            complement(6289..8412)
                     /locus_tag="AW272_RS10250"
     CDS             complement(6289..8412)
                     /GO_function="GO:0004560 - alpha-L-fucosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013300.4"
                     /locus_tag="AW272_RS10250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha-L-fucosidase"
                     /protein_id="WP_066363061.1"
                     /transl_table=11
                     /translation="MRSRFLRAALSLLVALTATVVVQSSPAAAAPGDNYVVDDALTSSR
                     TRWFDEARFGMFIHFGPYALYKGQYNNCREVEWIKRQCNIPWNEYEAKAATFNPTAFDA
                     NAIVQMAKQAGQKYIVITSKHHDGFAMWPTAVNRWNIRDHSGFNRDILRELKTAATANG
                     IKLGFYYSIWDWHDPDFTGNFPAYVTKMKAQLQELVTAYDPAVLWFDGEWTESNPVNPW
                     SAQNGEDLERYVRSIAPQAVINNRVGKRRALDGDFGTPEQALQGSAPSIQLNESCITIN
                     NTWGYAAWDTNFKTPTSMVRDLATLTSNGANLLLNIGPTDTGAVTTGQSDGLRGIGNWM
                     AVNSAAIHGAGHTGLVAQPSWGKVTRKGNKLYLIVNNWASTLHVTQRAPFTVTGARVIG
                     SGSPVTFQAAGDGYDFRPSGSATNSIATVIEADITPTAPRAVGTGTGLKGTYWNNTTFS
                     GSPAVIRTDPTVNYAWRYSGSPAPAINTDNFSARWTGTIEPRYSERYTFTTGSDDTVQL
                     WIDGQLVINNTTPHTAAVDQGSVTLVAGRRHEIRVDYTDRTNEAFMKLAWASPNTPAEI
                     VPKTQLYSTGATIRRVNQDAATYSTGWSTSSGRGYGDVNDDVQYTTTNGASFTYTFTGT
                     GVDFLSEKYSDQGLVDIYLDNVLRATVDTTSGTRQAAAVIWGVRNLSQGSHTLRGVKRS
                     GQYMLVDAFDVFS"
     misc_feature    complement(8395..8397)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8550..8565
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.16"
                     /tool="antismash"
     gene            complement(8652..9518)
                     /locus_tag="AW272_RS10255"
     CDS             complement(8652..9518)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="AW272_RS10255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_066363063.1"
                     /transl_table=11
                     /translation="MYHDLQINRLRALVTVVELGGFRKAAEALHVTQPAVSQQIRQLGG
                     LVKGPIFTSTGRILELSTEGEELLGYARRIVALNDEAVGRFVPPSGTARLTIGVVNQLA
                     EALPEILRLLNRGLPHVQVGVQTGLSESLENQVSSGQLDLALLLQSEPAAGPAHQLGEM
                     HMDWFGRPAHGEGAALPLTLFTEPCTLRRRIVDTLDASEVPWRVAYEGPELVGLRSAAK
                     AGLGVACLVANGDELWDLPRAARLALPSAPGPLPVTVALSANATHSEYVPIAERAFQQA
                     LRGYPFA"
     misc_feature    complement(9685..9701)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.66"
                     /tool="antismash"
     gene            9780..10019
                     /locus_tag="AW272_RS10260"
     CDS             9780..10019
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) triceptide_precursor"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AW272_RS10260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_066363066.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATMTHADEDWRFAELVMRAWTEPALAARYEDDPAGTLAQFGIDL
                     GADDAPPLSAGGDPLRIADLSEPSMKSAKWTYCG"
     gene            10001..11971
                     /locus_tag="AW272_RS10265"
     CDS             10001..11971
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="AW272_RS10265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_066363068.1"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 1.7e-09,
                     bitscore: 32.9, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 2.4e-20,
                     bitscore: 67.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 6.1e-12, bitscore:
                     40.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 6e-71, bitscore: 235.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLLRMKVGFKRHWRAVTVPGDGVYLTSARATVALHGDHIEEVAP
                     LLDGNHDLADLHEQTGIGAGDLGRLLGRLSEADLVAPRPDDDVAPEVRAYWDLAGLGLP
                     TGTVEVISLGDSSPAERALQDLGLRTGTAEKVLVVCDDYLDPALASINADRLADGRPWL
                     PVAVNGPDLWIGPGFQPGESACWECLAARLRIRRQAPPGFAPSAALPQTKSIGAQIAAV
                     RIAGWLAGQELHSLWTFDPLTLDAAHHPVTRRPQCPACGDSRTHSGPVEITSKPKVHAH
                     RSAGLQETWDRYVHLTDPATGVTDRVRRDPRAPGFLNSYLSGRNLALPVSGLRANSGGK
                     GGTPLEARVGALCEAVERYCGSRLGEEHVIHDSYRNIGEPAVHPDDVLLFDTRQRARFD
                     ESAEIEWTPLFTLDGGRRYLPTEMLYFTEGGQADSNGNAAGASIEDAILQGFFELVERD
                     AVGIWWYNRTRQPEVVLNDPWTDALKLDYARIGRDLWVLDLTTDIDIPAMAAVSTKNGQ
                     EVMLGFGAHLDPATAARRALTELGQLLPAATDIDMRPWWGRVSTRSHPCLLPDGVAGLS
                     SYRENGDLKADVELIRRFDPLVLDQTRPDIGLPVVKVVVPGLRHFWPRFAPGRLFDIPV
                     KLGRLDRPTAYDDLNPVALFM"
     aSDomain        10010..10180
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AW272_RS10265_Cyanobactin_D_RRE.1"
                     /evalue="7.90E-11"
                     /identifier="RREFam007.1"
                     /label="AW272_RS10265"
                     /locus_tag="AW272_RS10265"
                     /protein_end="60"
                     /protein_start="3"
                     /score="32.9"
                     /tool="antismash"
                     /translation="LRMKVGFKRHWRAVTVPGDGVYLTSARATVALHGDHIEEVAPLLD
                     GNHDLADLHEQT"
     aSDomain        10013..10303
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AW272_RS10265_Goadsporin_CD_RRE.1"
                     /evalue="1.10E-21"
                     /identifier="RREFam013.1"
                     /label="AW272_RS10265"
                     /locus_tag="AW272_RS10265"
                     /protein_end="101"
                     /protein_start="4"
                     /score="67.7"
                     /tool="antismash"
                     /translation="RMKVGFKRHWRAVTVPGDGVYLTSARATVALHGDHIEEVAPLLDG
                     NHDLADLHEQTGIGAGDLGRLLGRLSEADLVAPRPDDDVAPEVRAYWDLAGL"
     aSDomain        10016..10291
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AW272_RS10265_NHLP_CD_RRE.1"
                     /evalue="2.80E-13"
                     /identifier="RREFam015.1"
                     /label="AW272_RS10265"
                     /locus_tag="AW272_RS10265"
                     /protein_end="97"
                     /protein_start="5"
                     /score="40.7"
                     /tool="antismash"
                     /translation="MKVGFKRHWRAVTVPGDGVYLTSARATVALHGDHIEEVAPLLDGN
                     HDLADLHEQTGIGAGDLGRLLGRLSEADLVAPRPDDDVAPEVRAYWD"
     gene            11983..13431
                     /locus_tag="AW272_RS10270"
     CDS             11983..13431
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="AW272_RS10270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_066363070.1"
                     /sec_met_domain="PF00881 (E-value: 5.3e-16, bitscore: 54.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDTLPPFPLWSFREDVFVEPDTGEGVVVVHSRWEDTVLPMPAPP
                     VVEALRRMSLGPISLGNVIRSGADRRALTALLDDLAHLVVRSFGLDREQPLVSVVPLTP
                     QATFHLPQGPLVHPVRLSRFAVLTTDGTNYLLESPLSQHRVILHRADAIGHLGTLMRPT
                     VPAAVGAETRSVIAFLMAAGMVVEAATGDPFQRIEFAEDNDPALTMWAPIDLMFHTRST
                     LGRHDQDFGVTYPLGEHGSVEPVVKDTKAGISLPRPSWDDLAEDPPFSAVVEAHRPAQT
                     FSEEPMTLDDLGTLLYRTARVRALNGSPSTAATQTTSDRPCPTSGDLHELELYAVVDRC
                     AGLARGVYHYDPYHHRLTALDGDPDELLASANLASRPPVLLMITARFRRLSWKYNGLGY
                     SLVLTDAGALVQTLSLAGTAMGLAGCRVDGPDIDASAHVFGLDWRTESSVCGYAVGHAQ
                     PVVVGDGFPVNDADWPMLAAALLA"
     gene            13491..15665
                     /locus_tag="AW272_RS10275"
     CDS             13491..15665
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="AW272_RS10275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_169807520.1"
                     /transl_table=11
                     /translation="MARAVIGVVLFAYTFNALMFVWGEDLRGPPLAAFAACLLTGLGLQ
                     LVHSTRDVLFWSPPKKALSLMAQAAVMFAPFAWVGPQAGSVAGFLAGSMLLAVPGPLRW
                     ALYAAVPAAIFAVLTVLGMAPLDVVYGAYFTALTGLMVYGLSSLASLAQTVHAARGELA
                     GVAVAQERLRVARDVHDLLGYNVSALTLKSELAYRLLPGAADRARRELRDVLTLSRQAL
                     GDVRVVAGGSRPMSLAAEVRSAESMLIAADMDVEIALSPCPLPEEVDTVLAIVLREAVT
                     NVLRHSKAQHCLVETALAGDRIVLRVVNDGPDLPAEDLDGGAGLDNLSARVEAAGGTST
                     TVQDDEWFTFTAEVPIAQPVVEDPVTRTFAQITAQPWHLRVARTIAVVVLLGYGVLMVV
                     NVLAQGPGSLGLLEFALCVAVLVGVQIALALGFHLRGFALPAQAVATYLPLLWIGDPWG
                     SMGGFLAGTALIVLSGAWRWCCYAAVGVSVAALSVLNGDAGEWTVYLTLSTLLTGLVVY
                     GISSLTGLVAQVDQARDDLARGAVTRERLRVARELHDLLGNDLADMTVKSERAYRLLPG
                     SVDRARAELAEVLDVARRAVADVRSVASGYRHMSFTAELDSARATMTAAGVCVQVRSGE
                     PSGEVDALLAVVLREAVTNVLRHSAATRCEIVLTPPATLTVWNDGVPASAPPGEPGTAL
                     DDLAERLKSVGGSLKCERDSGAFLLKVDIP"
     misc_feature    13614..13616
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15751..16368
                     /locus_tag="AW272_RS10280"
     CDS             15751..16368
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012886893.1"
                     /locus_tag="AW272_RS10280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA-binding response regulator"
                     /protein_id="WP_066363075.1"
                     /transl_table=11
                     /translation="MGVLTLRILLAEDVRIVRGALAALLEIEPDLTVVAQVGSGADIVP
                     AALEHRPDVAIIDVDLPVIDGLSAAEELHVKLPSCRTLILTGLGRPGTLRRALSVSVSG
                     FLLKDTPSERLAQAVREVAAGRRIIDPQLALTAWDVGEIPLSGREIQVLRLAAGGAEPP
                     EIAAQMHVSVGTVRNYLTKIVTKLNARNRVDAIRIATEAGWI"
     misc_feature    15766..15768
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16408..17640
                     /locus_tag="AW272_RS10285"
     CDS             16408..17640
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545347.1"
                     /locus_tag="AW272_RS10285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lamin tail domain-containing protein"
                     /protein_id="WP_066363077.1"
                     /transl_table=11
                     /translation="MTYTLLRGNFVIRYPDLPRQGPEPDGDTIKFLPDTPALIEALPRP
                     SGTSPDLNRRGISVRLEAIDTLETHFEETHQRLEWANAARDRLLALLGFTGVEFFDDLP
                     NKVRRADQDSIRGYVLSNGIDANGRLIAFVYGGPTESPDGLPVFLTPETADASANRILL
                     AEGLAYPAYYATLPAELRDHLAGISRAARPSTGLWPHASGDPGRPATVTADTLDETIIW
                     PKLFRRLVPYFAAGHPNFDQFDAWLRADPVHRDDALWLIEKQELGNLHDVVRASGNTIE
                     LTAWPEDFVIAPDPATGPTTPSGVLTGDLLIVAALPNPVGADAGAEKITLLNVTPDPLK
                     LDGWHLRDGSGNKTPLSGAVEAGTVKVVNVSWLNNDGDSIMIVDPKGVVIDTVTYKADK
                     VRNGRTIAFGR"
     misc_feature    16441..16455
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     tRNA            complement(17736..17812)
                     /anticodon=(pos:complement(329519..329521),aa:Lys,seq:ctt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AW272_RS10290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Lys"
     gene            complement(17736..17812)
                     /locus_tag="AW272_RS10290"
     gene            complement(17864..18511)
                     /locus_tag="AW272_RS44900"
     CDS             complement(17864..18511)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894116.1"
                     /locus_tag="AW272_RS44900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_245657385.1"
                     /transl_table=11
                     /translation="MYAIKGILKNKTATTALAACGLAVLGLGATGAASALAAPPHAGHV
                     RIHTKPAAIVKPAKPAAIVQPAKPALKEPSFVKPAVLTGKTTASYFWDDASGRAGDTGL
                     PASGKPMQKGMAASPSWPLGTEGYVVYKGQKKPFFVGDRGPGVPSSKGIMLDLDGQTFA
                     ELTGGTFDMTSLAVKDNGGAGHIPIEYHITKWGTGTGLKADPVPFAIGAWRR"
     misc_feature    18822..18840
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.66"
                     /tool="antismash"
     gene            18828..19427
                     /locus_tag="AW272_RS10300"
     CDS             18828..19427
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653115.1"
                     /locus_tag="AW272_RS10300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_066363078.1"
                     /transl_table=11
                     /translation="MEILLQGATRLFAALGYDATTLKQIVDSTGLDPAEEGFDGSKRDL
                     YLAVIERAARIETEALEGVVNDMMAADHVTAAGAVHEIVDRYIDFCVANPEFPALWIHR
                     WLYDAADLTGLERQYSQPLITMTTSVLEQAAEAGYIDDSADMEYCVWTLIWCVHGFVQG
                     GVLDDAGDRLGAENPEVLARFRRHLHRLAERTLNLS"
     misc_feature    complement(19481..19494)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(19491..19505)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     misc_feature    19492..19506
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     gene            19535..21913
                     /locus_tag="AW272_RS45975"
     CDS             19535..21913
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893324.1"
                     /locus_tag="AW272_RS45975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_066363081.1"
                     /transl_table=11
                     /translation="MGPRLSSWRRVMMMAAAMLLAVTGLAVMQAPAGAAVACQVTYAKQ
                     WDNGSGFGANITINNLGDAVNPWRLTYTWPGNQTIQQGWNATWSQSGQNVTVVAPSWAG
                     NLGTGQSVQIGFNGQVSGTNTNPTSFSLNGTVCNGGPSPSPSPSPSPSPSPQQQSLIVT
                     PTSVSVPEGGTATYSVRLNRQPTSNVTVSTTAGSGDTNLTVSSGASLTFTTSNWATAQN
                     VTLAAAQDSDTTNGTRPFTVASSGLTSVTVNATEADDDTTQTQSLVVSSTAVTVNEGGT
                     GTYTVRLATAPSGNVTVTNTAGSGDTNITVSSGASLTFTTSNWQTAQTVTLAAAQDSDS
                     TNGTRPITVASSGLTSVTVTATESDDDGTPPPGRVDNPYAGAAGYVNPDWSAQAASEPG
                     GSAVANTSTAIWLDRIAAITSGSAGSNSKGLRDHLDLAVAQDAANGSTPVIIQVVIYNL
                     PNRDCSALASNGELLIAQNGLNRYKTEYIDVIAGIMADTKYANLRIAAIVEIDSLPNLV
                     TNLGVAKCAEAKSTGAYEQGVAYALGKLYAVPNVYNYVDAGHHGWLGWDTNFGPSADLF
                     GSTADLATGGKATVHGFITNTANYSALTEPYFSVNGSVNGQQIRQSRWVDWNFYIDELS
                     FAQAFRTRLVQEGFSSNIGMLIDTSRNGWGGSARPTAASTSTDLNTFVNNSRVDKRIHA
                     GNWCNQSGAGLGERPRSAPASGIDAYVWVKPPGESDGSSTQIDNNEGKGFDRMCDPTYG
                     GNDRNGNSATGALANSPLSGHWFSAQFRQLLANAYPPIS"
     gene            complement(21987..23105)
                     /locus_tag="AW272_RS10310"
     CDS             complement(21987..23105)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889497.1"
                     /locus_tag="AW272_RS10310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_066363082.1"
                     /transl_table=11
                     /translation="MPLRLAGPLRPGKGRRRAAGARTAFALAVLPFLMMLLVTLLDLST
                     GPEIGFLPLLAVGPAFASLTGGIRRTLLVGVTALVLALGLSAYNHLELRRAYITMGSIA
                     GVTAASALATVGRRRRERELAQVRSVAEVAQRVLLRPVPRRAGHMRVAVSYTSAMADAH
                     IGGDLYEVVVAPTGVRAIVGDVQGKGLEAVETAALVLGAFREAAHDEKDLEGVSAKLEK
                     ALNRRLSGEEFVTAVLAEFNLEETTMTLLNYGHPAPLVLRANGEIEFADPDDHVPPLGL
                     AVLGPEGPAPYTITFEPGDQILFYTDGVIEARDAFGRFYPLDDRVHLLNDDDPEAALES
                     LRRDLIAHIDGPPTDDAAMLLMRCREPGLDLP"
     misc_feature    complement(23178..23193)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.17"
                     /tool="antismash"
ORIGIN
        1 ccacggtgat caggaaggcg atggcggtga agaccagcac catgggccgg gaggcgcgca
       61 cccagtcggg cgccatgccg aagcggggca ggtagcgcgg cacgatgttg agcagcccgg
      121 ccagcgcgga cgcgcccgcg aaccacagga tggcgatggt cgacaggtcg taggcggtgc
      181 cgaaccagtc gccgagatac aggtgggcca gataggccag ggcccggccg ttggccgagc
      241 cgccctcggc gaactccgcc ggcgggatga gcacggtggt ggcgaagctg gaggcgatca
      301 ggaagacgct catgatcagc gcggccgtgg tcagcagctt gcgcgtgccc ttgacccgct
      361 cggcgacgtc acccctgacc agcggcatga cggccacgcc cgtctcgaac ccggacagcc
      421 cgagggcgag tttcggcatc acgtagagcg cgacggcgac catcgccatg gggctggcgt
      481 agtcggtgtc cagcgtgttc tgccagccga cgagcttgtc cggcgcggtg agcgcgtgct
      541 ggagggcgac gcccaccacg accacgttga gcgacagata gacggccacc agcacgacgg
      601 cgaccgagat cgcctcgctg aacccggcca ggaacaccgc gcccagcgcg gcgatgagcg
      661 ccagcgtgac cggcacctgc cagtcgccca ggaagtgcgg cacgaacggg ttgtgcagga
      721 tgtgcgcggt ggcgtcggcg gccgacagcg tgatggtgac gatgaacgcc gtggccacga
      781 acccgagcag gaacagcacc agcagcttgc cgcgccaccc gggcagcagc cgctccagca
      841 tcgacagcga gcccagccca tgagggctct gctcggccac ggcccgatag gtcggcagcg
      901 ccccgaacag cgtcagcgcg accagcacca gggtggcgat agggctgagc gcccccgccg
      961 ccagcgcggc gatgcccggc tggtagccga gcgtggagaa gtagtcgacc ccggtcaggc
     1021 acatgacctg ccaccaggag tgctggtgct cgggcggctc ctcgtcgtgc gaccctccgg
     1081 ccagtccttc tggacgcttc agacccttga ggagccatcg ccgcactgtg tgttcccgga
     1141 gcgtgccggt caccgggcca ccttcgtatc ggggcaagtc agacgagtgc acacgctact
     1201 gaggccgcgt atggaactcg tcaaggcggg gcgtcaagaa aacgtaaaaa atccggacgt
     1261 caggtcacgc aacacccgtc ggtgcatcta ccggaggccg agcccggccg tcgagtgttc
     1321 ggcctcaccg gcgtcgtcag gggatgcgga cggcgagcag ggcgatgtcg tctgtcgggt
     1381 gggggccggg gatgcgggtc gcgagggtgt gcaggagttc gtcgaggggc tggtcgtggt
     1441 gttcggccag gaggcggatg gccagggcga tgtcgtgctc gacgtcgctg ccgggccggt
     1501 cgatgaggcc gtcgctgtag agcaggagcg tcgacccgga cgggagcgcg cgccggtggt
     1561 cgaggcgggg gtgcgggtgc agcttgggga agatcagcag gccgtattcg aggagctggt
     1621 cgaccgtgcc gtcggggtgg agcaggagcg ggcgggggtg gccggcgttg gtccaggtga
     1681 aggtccaggc tccggcggtg tcacggtcga gctggccctg gacgagggtg ccggaggcgg
     1741 tgatcggcag gttgtcgcag gcgtattcga gagcggtgac ggccgcggcg ggtccctgcc
     1801 cggggtggtc gatcaccgcc tggcggagca tgttgcggac ctggcccatc agggccgccg
     1861 cgtggatgtc gtggccggtg atgtcgccga tcgtgacggc cagggagacg tcgacgccct
     1921 catcggcggg gatgacgaag gcgtcgtacc agtcgccgcc gaccaggtcc ttggcggcgg
     1981 cgggctggta gagggcggcc atggccaggc cgggcacatc ggggagatcg gtgagcatcg
     2041 cggtctggag gttcagcgcg gtgtcgtgtt cgtgctggaa gcgggtggcg ttgcccaggg
     2101 cgagcgcggc acggtcgatc agctggaaga ggaaggggcg ctccagattc gtccgggcgg
     2161 cggcggtcag cccgctcagc tccacggcgc cgatgtagtc gccgccgtag atcagcggca
     2221 ggacgagccg gtcgtcggcc gcctcgcccg tgccgtgcag gagccgccgg gaggagtcgg
     2281 gggtcttctc gtgcagccag atgctggtcg tctcgccgta ggcgggggtg aggtgccggg
     2341 cgagggtggc cgcgatcgca ccgggatcga ggctggtgtt gagctggtgg gtgatgtcgg
     2401 cgagcagctg gatgcgggtc gcggcggccc ggcgctggcg ggtggtggtc agatgcgtcc
     2461 gtacgcgggc cagcagctcg gccgtggtga agggtttgac gaggtagtcg tcggcgccct
     2521 cgtccagccc ctcgatgatc gcctcggtgc cggcgcgggc cgacaccatc accaccggga
     2581 tgtcgctggt cgccgcgttc cgccgcagcg ccttcagcag gccgaaaccg tcgagcctcg
     2641 gcatcatcac gtcggtcagc accagctcgg gcggctgccg taggacgctc tccagggcgg
     2701 cctggccgtc gccgacggcg cggacccgcc aatggggtga cagcgcccgg accagatgcg
     2761 cccgcatgtc ggcgttgtcg tcgacgacca gcacctcgac cgggccgcct gactcgtcgc
     2821 ggtgatcggc gccgtcgacc cagctgaagg cttcgctgac gtacaccgcg gcctcgggct
     2881 cctcacgcgt ccgcaccggc gcgttcgagg cggccgccgc cgcggtcgcg cggaagggca
     2941 gcagggccgt gaaggtgctg ccccggccgg gttcgctggt cacctcgatg gtgccttcgt
     3001 gccggtgcag caggtctctg accagggaga gcccgatccc gctgccctcg acgctgcggg
     3061 aggcgctgtc ttcgacccgg tggaagcggt cgaagatgag cggcagctcc tccggggaga
     3121 tgccgacccc ggtgtcggtg acgcgcagcc gggcgcggcc gtcgtgggcg tcgacgccga
     3181 gggtgatccg gccgccgagc gtgtacttga aggcgttgga catcaggttg aggacgatct
     3241 ggtcccaggc cgggcggtcg acccagaccg gttcgggcag cggacggcag tccagaacga
     3301 gggtgacgcc gccgtgttcg agggcgggcc cgaacagcgc ggccagttcg gcggtgtagg
     3361 cggagaggtc gacgggctcg aacctgagct ggtcggcgtg gccggcgctg gtgaagtcga
     3421 gcagggtgtt gacgtggcgg agcagccgca gggcgttgcg gtggaccatc tccacctgct
     3481 cgcgctccgg tgtggccggg tcggccagca ggccctccag cggtccgagc atgagggtca
     3541 gcggggtgcg cagctcgtgg ctgacattgg cgaagaaggt ggtcttggcc cggtcgagcg
     3601 cggcgaggcg ttcggcccgg tgccgggcgg cgtccagcgc cgaggcgtcg gtgatcgccg
     3661 ccgcgacctg gccggtcagc aggttcagga aggtccggta ggcggcgtcc agcgggcgcc
     3721 cggggttgat ccccaccacc aggaaccccg cgggctgatc ggccgccgtg atcggcagca
     3781 ccagggcccg ggacggcggc gcgaaccgat cgcgcgccat ccgctccagc cgggggtcgg
     3841 ccgggcagcc gacctcgacc ggcccgccca gggcctctcc cagtggccac gcgcctcccg
     3901 aatggagcgg cacgaccggg ggagccgccg cgtcaccggc gaccagcccg gccgcggaca
     3961 ccagcacggt ctggtcgctg ccgggctcca gcaggtagag cagcgcgaag ggcacgtcga
     4021 ccggatgacg ggcgaacacc tgcgcggccc gctcgcacgc ctcggccgcc gacccggcgg
     4081 tgcgggtgtg ctcgctcagc tcggcctgga cggccgtccg ccgcgccccc accacctcgg
     4141 cggtggtctc ggtgacggtc gcgaacaccc cgccgacctc gcccgtctcg gtgatgatcg
     4201 ggctgtagca gaaggtgaag tagcactcct cggcgaacct gccccgctcc agcacgaccg
     4261 ggaggtcttc gaagaacgcc gactcccggt cggccacgac ccccgcgagc atcgggccga
     4321 cgagatccca cgtctccgac cagacctcgc gcgccggccg tcccagggcc gccggatgct
     4381 tggaccccag caccgggatg aaggcgtcgt tggtgagctg gatcatctcc ggcccccaga
     4441 acacgaagca cgggaagcgc gacaccaggc agaggctcac cgcgctgcgc agcgactgcg
     4501 gccacccggc catcggcccg atcggcgagc aggaccagtc gtgggccgcg atcatctcgc
     4561 ccatgagccc gccggccatg agcacagctc tcatcgctgc gggcggttcc tcgaaccgct
     4621 ccgccgaagg cccggtcacg gcgacatcat cccaggatca tgccgccctt ccccgccggc
     4681 aggctgccgt tttcccgaat cgcgatgaac ctccgggttg gacgcgaaaa agcccgcatc
     4741 cggcgaccgg ccagacccct gggaccggac gtcggatgcg ggcgtgcaac ctcctagtgc
     4801 ccgtggagga gagggcaaac gtcattctcg atttagggct cgccgaagcc gaagttacgg
     4861 tggatcacgt tcgagctctt ggtcatgcgg gagtatccgg gggcctcgaa gatgatcttg
     4921 gtgtagatct cgtcgccgta gtcgaacggc ggcttgtcgt cctcgtcgag gtaactgaca
     4981 cacgagaggt gcaggtcgga gacgatcagg agaccgcccc cgttcttgtc cgacaccggg
     5041 atcagggtcg ctttcggccc tttgtacacg cggttgtcgt agatcgggtc gtcggcccag
     5101 acctcgaccc gggccgtcgc gccgttgtcg accagatact gcgcctgggc gttcgtcatc
     5161 ccgaccttgc cggtggtgaa gatccggcag tcgctgccgc ctccggtgat gaccaggcgc
     5221 gcggtcagtt tgccggcctc gtcggcggcg tgggcggggg tgccgagggc gaacaccgct
     5281 gcggcggtca cggcggcgac gcgggtgagc ttcttgaaag gggacacggg tttctcctgt
     5341 gcggcagtgg cggtcgatac gcaccattcg tccgcctgct tgcactgggc ttgaagctcg
     5401 gcgatgagcg ccgcgagaaa tgccttcccc aggcaggtga cctgcgcatt caccggtgga
     5461 ccactcaacg tgggccactt cggcgggaat tgagtaaagg cgtactcaag cccacggcaa
     5521 gccccccgcc gcaccatggg cgcatgaaac gcctcgcgct cctcgggtcg gccgctctcg
     5581 tggccgccgc cgtcaccgtc cccgcctcgc ccgcgctggc ggccgcgccg ctggccggtg
     5641 ccgcgacctg cgccgacgtc gatctcgtct tccagcagaa gtccgccttc ccggacacga
     5701 cccggggtcg ctacgaccac atgatgcagg ggagcaggat cgagaagtcg gtccagtgcc
     5761 tggtcaacgc cgagcgcgcc gcccggggac tgcagcccgt caagcggtac atcgccctgc
     5821 gcgggacgac cgtcgcgctc agcagcgcca cggccaagca ggtcgcggcc gccgtccgga
     5881 tccgctggtg ggggacggtc gcgcaggtcg ggaactgtac gccgctgaag tccgacccga
     5941 gccgctgcga cgtccacgtc aacccggaga ccgggaccga cccgggagcc agggcgaaag
     6001 cggccggata ctgcaagcgc ggcacctcgt gggccgtcgg cgagaacgcc tacctcggct
     6061 ggggcagccc gtcggtcacg cccagggccg ccgtcacctg gtggatgggc agcccacccc
     6121 accgggccac gatcctcacg cccggctaca ccgagctgta cacgaaggcc gcctacggca
     6181 gcgccgaccc gtctgtgtcg gccaccccgg ccgtgacgta tgtgcagatg ttcggccggt
     6241 gcagcagctg agaggagagc ctccggtgcg gaggctctcc cgcgtcggct aggagaagac
     6301 gtcgaacgcg tcgaccagca tgtactggcc tgaccgcttg acgccgcgca gggtgtgcga
     6361 cccctgcgac aggttgcgga cgccccagat gaccgcggcg gcctggcggg tgccgctggt
     6421 cgtgtcgacg gtggcccgca ggacgttgtc gaggtagatg tcgacgagac cctggtcgga
     6481 gtacttctcc gacaggaagt cgacgccggt gccggtgaag gtgtaggtga acgacgcgcc
     6541 gttggtggtc gtgtactgca cgtcgtcgtt cacgtcgccg tagccccggc cgctgctggt
     6601 ggaccagccg gtgctgtagg tggccgcgtc ctggttgacc cggcggatcg tggcgcccgt
     6661 cgagtagagc tgcgtcttcg gcacgatctc ggccggggtg ttcgggctcg cccaggcgag
     6721 cttcatgaac gcctcgttgg tccggtcggt gtagtcgacg cggatctcgt ggcggcgacc
     6781 ggcgacgagg gtcacgctgc cctggtcgac ggcggccgtg tgcggggtgg tgttgttgat
     6841 gacgagctgc ccgtcgatcc acagctggac ggtgtcatcc gacccggtgg tgaaggtgta
     6901 gcgctcggag tagcgcggct cgatcgtgcc ggtccagcgc gcggagaagt tgtcggtgtt
     6961 gatcgccggg gccggggagc cgctgtagcg ccaggcgtag ttgacggtcg ggtcggtcct
     7021 gatgaccgcc ggggaaccgg agaacgtggt gttgttccag tacgtcccct tgagcccggt
     7081 gccggtgccg accgccctgg gggccgtcgg ggtgatgtcg gcctcgatga cggtggcgat
     7141 ggagttggtg gccgagccgc tcggccggaa gtcgtagccg tcgccggccg cctggaaggt
     7201 caccggtgag ccgctgccga tcacccgtgc gccggtcacc gtgaacggcg cccgctgggt
     7261 gacgtgcagg gtgctcgccc agttgttgac gatcaggtag agcttgttgc ccttacgggt
     7321 gaccttgccc cagctcggct gggcgaccag gccggtgtgg cccgcgccgt ggatggcggc
     7381 gctgttgacg gccatccagt tgccgatgcc gcgcaggccg tcggactggc cggtggtgac
     7441 cgcgccggtg tcggtcgggc cgatgttgag cagcaggttc gcgccgttgc tggtcagggt
     7501 cgccaggtcg cgcaccatcg aggtcggcgt cttgaagttc gtgtcccagg ccgcgtagcc
     7561 ccaggtgttg ttgatcgtga tgcacgactc gttgagctgg atcgacggcg cggaaccctg
     7621 gagcgcctgc tcgggggtgc cgaagtcgcc gtcgagggcg cgccgcttgc ccactcggtt
     7681 gttgatgacg gcctgagggg cgatgctgcg gacgtaccgc tcaagatctt cgccgttctg
     7741 cgccgaccac gggttgaccg ggttgctctc ggtccactcg ccgtcgaacc acagcacggc
     7801 cgggtcgtag gcggtcacca gctcctggag ctgggccttc atcttggtga cgtaggccgg
     7861 gaaattgccg gtgaagtcgg ggtcgtgcca gtcccagatg gagtagtaga agccgagctt
     7921 gatgccgttg gcggtcgcgg cggtcttcag ctcgcgcagg atgtcgcggt tgaagcccga
     7981 gtggtcgcgg atgttccacc ggttgacggc cgtgggccac atggcgaagc cgtcgtggtg
     8041 cttggaggtg atgacgatgt acttctgccc ggcctgcttg gccatctgca cgatggcgtt
     8101 cgcgtcgaac gcggtggggt tgaacgtggc ggccttcgcc tcgtactcgt tccacgggat
     8161 gttgcactga cgcttgatcc actcgacctc gcggcagttg ttgtactgac ccttgtacaa
     8221 cgcgtacggc ccgaagtgga tgaacatccc gaagcgcgcc tcgtcgaacc aacgggtgcg
     8281 tgacgaggtc agcgcgtcgt cgacgacgta gttgtcgccg ggcgcggcgg cggcgggcga
     8341 cgactgcacg acgaccgtgg ccgtcagcgc cacgagcagt gacagggctg cccgtaagaa
     8401 tcttgaccgc atgaagtcct ctcaggtggc tggatgcgat cagctcgccg ccgcgtgtac
     8461 gccgctacat ggggaggcga accagacgaa atgtacgtgc aacattgacg ccccgaaaca
     8521 tccgacctgt caaggatcaa acggggattg attactaatg tattcaagca atcacccggc
     8581 atgatcgggc ttgtggtgcc tccgtgcctg ctcacgcgag ggccacacgt aggatgtctt
     8641 ccgcccaggg gtcaggcgaa cgggtagccg cgcagcgcct gctggaaggc ccgctccgcg
     8701 atcggcacgt actccgaatg ggtcgcgttg gccgagaggg cgaccgtcac cggcaggggg
     8761 cccggcgcgg agggaagcgc gagccgggcc gcgcggggca ggtcccacag ttcgtcgccg
     8821 ttggcgacga gacaggcgac gccgaggccg gccttcgcgg cggagcgcag cccgacgagt
     8881 tcgggcccct cgtaggccac tcgccagggg acctccgacg cgtcgagggt gtcgacgatg
     8941 cggcggcgca gggtgcacgg ctcggtgaag agggtcagcg gcagggcggc gccttcgccg
     9001 tgggcggggc ggccgaacca gtccatgtgc atctcgccca gctggtgggc ggggccggcg
     9061 gccggttccg actggaggag cagggccagg tcgagctggc ccgacgacac ctggttctcc
     9121 agcgactcgc tcaaccccgt ctgcacgccg acctggacat ggggcagccc acggttcagg
     9181 aggcggagga tctcggggag cgcctcggcg agctggttga ccacgccgat cgtcaggcgg
     9241 gcggtgcccg acggcgggac gaaacggccc acggcctcgt cgttcagcgc gacgatccgg
     9301 cgggcgtagc cgagcagttc ctcgccctcg gtgctgagct ccaggatgcg gccggtcgag
     9361 gtgaaaatgg gccccttgac gagaccgccg agctgacgga tctgctggct caccgccggc
     9421 tgggtcacat gcagcgcctc ggccgcctta cggaacccgc cgagctcgac cacggtcacc
     9481 aaagccctca gccgattgat ttgcagatcg tgatacatgc catttccctt aataaggcag
     9541 atggaccccg gacggtgtcc gcgtgtcgat gtcccggacc gtcccgggcc gcggcctcac
     9601 gggccggcgg attcgaatgc gattcacgag gctcagccta gaagcgctta catccggtcg
     9661 tctgtacgtg gtttcacgat cccgatgtga aaatctcaca cccgtctcgt gaatcgatga
     9721 ctgtcgacgc gcgggccgcc ctgcggagaa tcgaagacga tccgacagga ggattttcca
     9781 tggccacgat gactcacgcg gacgaagact ggcgattcgc cgaactggtg atgcgggcgt
     9841 ggacggaacc cgctctggcc gcccgctacg aagacgaccc ggccggcacc ctggcccagt
     9901 tcggcatcga cctcggcgcc gacgacgcgc cgccgctgtc ggcgggcggt gacccgctgc
     9961 gcatcgccga cctgtccgaa ccatcgatga aatccgcgaa atggacctac tgcggatgaa
    10021 ggtcgggttc aagcggcatt ggcgagcggt gaccgtgccc ggtgacgggg tctacctgac
    10081 ctcggcccgc gccacggtcg ccctccacgg cgaccacatc gaagaggtcg cccccctcct
    10141 cgacggcaac cacgacctgg ccgacctgca cgaacagacc gggatcggag ccggcgacct
    10201 ggggcggctg ctcggccggc tgtccgaggc cgacctcgtc gcgccgcggc ccgacgacga
    10261 cgtggcgccg gaggtccggg cctactggga cctggccggg ctcggcctgc ccaccggcac
    10321 ggtcgaggtg atctcgctcg gcgattcctc gccggccgag agggctctcc aggatctggg
    10381 cctgcgcacc ggcacggccg agaaggtgct ggtcgtctgt gacgactacc tcgatcccgc
    10441 gctcgcgtcg atcaacgccg accgcctcgc cgacggacgg ccgtggcttc ccgtcgcggt
    10501 caacggtcct gatctgtgga tcggcccggg attccagccg ggggagtcgg cctgctggga
    10561 gtgtctcgcg gcccgcctca ggatccggcg gcaggcgccg ccggggttcg cgccgtccgc
    10621 cgccctgccg cagacgaagt cgatcggcgc gcagatcgcg gccgtgcgga tcgcgggatg
    10681 gctggccggg caggagctcc acagcctgtg gacgttcgac ccgctcaccc tcgacgccgc
    10741 gcaccacccc gtgacccgac gcccgcagtg cccggcctgc ggtgactcgc gaactcacag
    10801 cggacccgtg gagatcacgt ccaagcccaa ggtgcacgcc cacaggtcgg ccggcctcca
    10861 ggagacctgg gatcgctacg tccacctcac cgacccggcc accggcgtca ccgaccgggt
    10921 ccgccgcgac ccccgcgccc ccggatttct caactcctac ctctccggcc gcaacctcgc
    10981 cctccccgtc agcggcctgc gggccaacag cggcggcaag ggcggcaccc cgctcgaggc
    11041 gcgggtgggc gcgttgtgcg aggccgtgga acgttactgc ggctcccgcc tcggcgagga
    11101 acacgtcatc cacgactcct accgcaacat cggcgagccg gccgtgcacc cggacgatgt
    11161 cctgcttttc gacacccgtc agcgcgcccg cttcgacgag agcgcggaaa tcgaatggac
    11221 cccgctcttc accctcgacg gcggcaggcg ttacctgccc accgaaatgc tctatttcac
    11281 cgaaggcggc caggccgact ccaatggaaa cgccgccggg gcctccatcg aagacgccat
    11341 tcttcagggc ttcttcgagc tggtcgaacg cgatgcggtc ggaatctggt ggtacaaccg
    11401 gacccgtcag cctgaggtcg tcctgaacga cccgtggacc gacgcgctga aactcgacta
    11461 cgccagaatc ggccgtgacc tgtgggtcct cgacctgacg accgatatcg acatcccggc
    11521 catggccgcc gtctccacga agaacggcca ggaggtcatg ctgggtttcg gcgcccatct
    11581 ggatccggcg acggccgccc gccgcgccct caccgaactc ggccagctcc tccccgccgc
    11641 cacggacatc gacatgcgcc cgtggtgggg ccgcgtctcg acccggagtc atccctgtct
    11701 gcttcccgac ggggtggccg ggctcagttc gtacagagag aacggagatc tgaaagccga
    11761 cgtcgagctg atccggcggt tcgatccgct cgttctcgac cagacccgcc cggacatcgg
    11821 gcttcccgtc gtgaaggtcg tcgttccggg gctgcggcat ttctggccac gtttcgcccc
    11881 gggcaggttg ttcgacatcc cggtgaaact ggggcggctc gatcggccga ccgcttacga
    11941 cgacctgaac ccggtcgccc tgttcatgtg agaggagccg acatgcacga cacgctcccc
    12001 ccattcccgt tgtggtcgtt ccgcgaggac gtcttcgtcg aacccgacac cggcgagggc
    12061 gtggtcgtcg tgcactcacg ctgggaggac accgtcctgc ctatgcccgc gccgcccgtc
    12121 gtcgaggcgc tgcgccggat gagcctgggg cccatctcgc tcggcaacgt gatcagatcg
    12181 ggcgccgacc ggcgggccct gacggcgctg ctcgacgacc tggcccatct ggtcgtgcgg
    12241 tcgttcggcc tggaccggga gcagccgctg gtgtccgtcg tgccgctcac cccgcaggcc
    12301 accttccacc tgccgcaggg cccgctggtt catccggtgc gcctgtcgcg cttcgccgtc
    12361 ctcaccaccg acggcaccaa ctacctgctg gaatcgccgc tgtcgcagca tcgcgtgatc
    12421 ctgcaccgcg ccgacgcgat cggccatctc ggcacgctga tgcgcccgac cgtcccggcg
    12481 gcggtcggcg cggagacccg gtcggtgatc gccttcctga tggcggcagg gatggtcgtc
    12541 gaggccgcga ccggcgaccc gttccagcgg atcgagttcg ccgaggacaa cgatcccgcg
    12601 ctgaccatgt gggccccgat cgacctgatg ttccacaccc gctccacgct gggccgccac
    12661 gaccaggact tcggcgtgac ctatccgctc ggcgagcacg gcagcgtgga accggtcgtg
    12721 aaggacacca aggcgggcat ctcgctgccc cggccctcct gggacgacct ggccgaagac
    12781 ccgccgttct ccgccgtcgt cgaggcgcac cggccggccc agaccttctc cgaagagccg
    12841 atgaccctcg acgacctggg cacactcctc tatcggaccg cccgggtccg cgcgctgaac
    12901 ggctcgccct ccaccgcggc cacccagacc acgagcgacc ggccctgccc gaccagcggc
    12961 gacctgcacg aactggagct ctacgccgtc gtcgaccggt gcgccggcct ggcccgaggg
    13021 gtctaccact acgaccctta ccaccacagg ctgaccgcgc tcgacggcga cccggacgag
    13081 ctgctcgcct cggcgaacct ggcctcccgg ccgcccgtgc tgctgatgat caccgcgcgg
    13141 ttccggcggc tgtcgtggaa gtacaacggc ctcggctact cgctcgtgct caccgacgcg
    13201 ggagcgctgg tgcagacgtt gtcgctggcc gggacggcca tgggcctcgc cggatgccgg
    13261 gtggacggcc ccgacatcga cgcctcggcg cacgtgttcg ggctcgactg gcggaccgag
    13321 tcgagcgtct gcggctacgc cgtaggccac gcccagcctg ttgtcgtcgg tgacggattc
    13381 cccgtcaacg acgccgattg gccgatgctc gccgccgccc ttctcgcata agccgaaatt
    13441 tccgggtaag tgagggctct gtggtgtcgt taggaatgcg gcccggaacc atggcgcgcg
    13501 ccgtcatcgg cgtcgtgctg ttcgcctaca ccttcaacgc cctgatgttc gtctggggcg
    13561 aggacctgcg cggcccgcct ctggccgcct tcgccgcctg cctgctgacc gggttagggc
    13621 tccagctcgt ccactcgacc cgcgacgtcc tcttctggtc cccgccgaag aaggcgctct
    13681 cgctcatggc ccaggccgcc gtcatgttcg cgccgttcgc ctgggtgggc ccgcaggccg
    13741 ggtcggtcgc cgggttcctc gccggttcga tgctcctcgc cgtcccgggt ccactgcgct
    13801 gggctctgta cgccgccgtc cccgccgcca tcttcgcggt cctcacggtg ctgggaatgg
    13861 ccccgctcga cgtcgtctac ggcgcctatt tcaccgccct gaccggcctg atggtctacg
    13921 gcctcagctc cctggcctca ctggcccaga ccgtgcacgc cgcccggggc gaactggccg
    13981 gagtggccgt cgcccaggag cggctgcggg tggcccggga cgtccacgac ctgctcggat
    14041 acaacgtctc cgcgctgacc ctgaagagcg aactggccta ccgcctgctc cccggcgcgg
    14101 ccgaccgcgc ccgccgcgaa ctgcgcgacg tgctcacgct gtcgcgccag gcgctcggcg
    14161 acgtcagggt ggtcgcgggc ggcagccggc cgatgtcgct ggcggccgag gtgcggtcgg
    14221 cggagtcgat gctgatcgcc gccgacatgg acgtcgagat cgccctgtcg ccctgcccgc
    14281 tgccggagga ggtcgacacg gtcctggcca tcgtgctgcg cgaggccgtc acgaacgtgc
    14341 tccggcacag caaggcccag cactgcctgg tggagaccgc gctggcaggc gaccgcatcg
    14401 tgctgcgcgt ggtcaacgac ggccccgacc tcccggcgga ggacctggac ggcggcgcgg
    14461 gcctggacaa cctgtcggcc cgcgtcgagg cggccggcgg caccagcacc accgtccagg
    14521 acgacgagtg gttcaccttc accgccgagg tcccgatcgc ccagccggtc gtggaagacc
    14581 cggtgaccag gacgttcgcc cagatcaccg cccagccctg gcacctgcgg gtggcccgca
    14641 cgatcgccgt cgtcgtgctg ctcggctacg gcgtgctgat ggtcgtgaac gtcctggccc
    14701 agggccccgg ctccctcggc ctgctggagt tcgccctctg cgtggccgtg ctggtcggcg
    14761 tgcagatcgc cctggccctg ggctttcatc tacggggctt cgccctgccg gcgcaggcgg
    14821 tggcgaccta cctccccctg ctgtggatcg gcgacccctg gggctcgatg ggcggcttcc
    14881 tggccggtac ggcgctgatc gtcctgtccg gcgcctggcg ctggtgctgt tacgccgccg
    14941 tcggcgtcag cgtggccgcc ctgtcggtgc tcaacggcga cgcgggggag tggaccgtct
    15001 acctcaccct ctcgaccctg ctgacaggcc tggtcgtgta cggcatcagc tcgctcaccg
    15061 gcctcgtcgc ccaggttgac caggcccgcg acgacctggc ccgcggcgcc gtcacccgcg
    15121 aacgtctacg cgtggcccgc gaactccacg acctgctcgg caacgacctg gccgacatga
    15181 cggtgaagag cgaacgcgcc taccgcctgc tgcccggctc ggtcgaccgg gcccgcgccg
    15241 aactcgccga ggtcctggac gtggcccgcc gcgccgtcgc cgacgtcaga tcggtcgcga
    15301 gcggctaccg ccacatgtcg ttcaccgccg aactcgactc cgcccgcgcg acgatgaccg
    15361 cggccggggt gtgcgtccag gtgcgttccg gggagccctc cggggaggtc gacgcgctgc
    15421 tggcggtcgt gctccgggag gcggtcacga acgtcctgcg gcacagcgcc gccacccgct
    15481 gcgagatcgt cctgacccca cccgcgaccc tgaccgtctg gaacgacgga gtcccggctt
    15541 cggcgcctcc gggtgaaccc ggcaccgccc ttgatgacct ggccgaacgc ctgaaatccg
    15601 tcggcgggtc gttgaaatgt gaacgagatt ccggggcgtt cctactaaag gtcgacatcc
    15661 cataatgacg ctctgtcaag aatgtccggc attgcctatt tccgccacgt cggtacaaga
    15721 ttcattttga ccttgaaacc ggccggggga atgggcgtgc tcacgttacg gatcctcctc
    15781 gccgaggacg ttcgcatcgt ccggggcgcc ctggccgcac tcctggagat cgagcccgac
    15841 ctcaccgtgg tcgcccaggt cggcagcggc gccgacatcg tcccggcggc cctggaacac
    15901 cgccccgacg tggccatcat cgacgtcgac ctccccgtga tcgacggcct gtccgccgcc
    15961 gaggaactcc acgtcaaact cccgtcgtgc cggaccctga tcctcacggg cctgggccgc
    16021 cccggcacgt tgcggcgggc cctttccgtt tcggtgtccg gcttcctgct gaaggacacc
    16081 ccgtcggaac ggctggcgca ggccgtacgg gaggtggcgg ccggccgcag gatcatcgac
    16141 ccgcagctgg cgctgaccgc atgggacgtc ggcgagatcc ccctttcggg gcgtgagatc
    16201 caggtgctgc gcctggcggc cgggggagcg gaacccccgg agatcgccgc ccaaatgcac
    16261 gtttcggtcg gaacggtgcg caattacctg accaaaatcg tcaccaaact caacgcgaga
    16321 aatcgtgtgg acgcgatacg catagccaca gaagcaggct ggatctgaat tccgggcccg
    16381 gctattctcg ccgaggggtg ataggcgatg acatatacac ttttgcgcgg caatttcgtg
    16441 atcagatatc ccgatctccc gcgccagggc cccgagcccg acggtgacac catcaagttc
    16501 ctgcccgaca cgcccgcgct gatcgaagcg ctccccaggc cctcggggac gtccccggac
    16561 ctgaaccggc ggggcatctc ggtccgcctg gaggcgatcg acacgctgga gacgcacttc
    16621 gaggagaccc accagcgact ggaatgggcg aacgcggccc gtgaccggct gctggccctg
    16681 ctgggcttca cgggcgtcga gttcttcgac gacctgccga acaaggtcag acgggctgat
    16741 caggactcga tccgcggcta cgtgctctcg aacgggatcg acgccaacgg gcggttgatc
    16801 gccttcgtgt acggcggccc gacggaatcg cccgacgggc tgccggtctt cctgaccccc
    16861 gagacggccg acgcttcggc caaccggatc ctgctggccg aaggtctggc ctacccggcc
    16921 tactacgcga ccctgccggc cgagttgcgg gaccacctgg ccgggatctc acgcgccgcc
    16981 cgcccctcca cggggttgtg gccccacgcg agcggcgatc cgggccgccc ggccaccgtc
    17041 accgccgaca ccctcgacga gacgatcatc tggccgaagc tgttccggcg gctggtgccc
    17101 tacttcgccg cgggccaccc gaacttcgac cagttcgacg cgtggctgcg cgccgacccg
    17161 gtccaccgcg acgacgcgct gtggctgatc gagaagcagg aactcggcaa cttgcacgac
    17221 gtggtccgcg cgagcgggaa cacgatcgag ctcacggcct ggcccgagga cttcgtcatc
    17281 gccccggacc cggcgaccgg cccgacgacg ccttccggcg tcctcaccgg cgacctgctc
    17341 atcgtggcgg cgctgccgaa cccggtgggc gccgacgcgg gggccgagaa gatcaccctg
    17401 ctgaacgtga cccccgaccc gctcaagctg gacggctggc accttcgcga cggctccggg
    17461 aacaagacgc cgctgtcggg cgcggtcgag gcgggcacgg tgaaggtcgt caacgtgagc
    17521 tggctcaaca acgacggcga ctcgatcatg atcgtcgacc cgaagggcgt cgtgatcgac
    17581 accgtgacgt acaaggccga caaggtccgg aacggccgga cgatcgcctt cggccgctga
    17641 cgggtgcggc ggatcccccg ggtccgccgc agtcgcgcat gtcgtgccgt ggaacgagaa
    17701 aatcccaact cagccgaacc gagttgggat ttctttggtg cgccgccagg gactcgaacc
    17761 ccggacccgc tgattaagag tcagctgctc taaccaactg agctagcggc gccaacgaga
    17821 aaactttagc agctccctca cccgtaacgc acatccttag cggtcagcgc cgccacgcgc
    17881 cgatcgcgaa cggcaccggg tcggccttga gtccggtccc ggtcccccac ttggtgatgt
    17941 ggtattcgat cgggatgtgg ccggctccgc cgttgtcctt cacggccagg ctggtcatgt
    18001 cgaaggtgcc gccggtcagc tccgcgaagg tctgcccgtc gaggtccagc atgatcccct
    18061 tggaggaggg cacgcccggt ccgcggtcgc cgacgaagaa cggcttcttc tgtcccttgt
    18121 agaccacgta tccctcggtc cccaggggcc agctcggcga ggcggccatg cccttctgca
    18181 tcggcttgcc gctcgcgggc aggccggtgt cgccggcccg gccggaggcg tcgtcccaga
    18241 agtaggaggc ggtggtcttg ccggtcagca cggccggctt gacgaagctg ggctccttca
    18301 gcgcgggctt cgccggctgc acgatcgcgg cgggcttggc cggcttcacg atcgcggcgg
    18361 gcttggtgtg gatgcggacg tggccggcgt gcggaggagc ggccagcgcg ctggcggcgc
    18421 cggtcgcgcc caggccgagg acggccagtc cgcaggcggc gagggcagtg gtcgcggtct
    18481 tgttcttcag gatgcctttg atggcgtaca tgaaaaaggg agatcttccg tacgacgaca
    18541 ggactgccac tcgggtcaga tgaggtggcg ggtccggcgg gccctggagg ccgctgcccg
    18601 gactgggagg tcaagtgctg gcttgtggga tggtcagctc ttggcaacga aaccgacact
    18661 agtgaccaaa ccatgacaag gcaaacgtaa gacagtaaaa catctcagaa aggcatgaaa
    18721 cgcccatgaa tcaggggatt ccggcgtcaa gcgtgccgtt tgctctcccg tgaccggtcg
    18781 gctgctggac ttggaaaagg taaggaccaa gggatcggga gccctggatg gaaatcctgc
    18841 tgcagggggc cacacgactg ttcgccgcac tcggatacga cgccacgacc ttgaagcaga
    18901 tcgtcgactc gaccggactc gacccggccg aggagggctt cgacgggtcg aagcgggacc
    18961 tctacctggc cgtcatcgag cgggccgccc ggatcgagac cgaggcgctc gaaggcgtcg
    19021 tcaacgacat gatggcggcc gaccacgtga cggcggcggg ggcggtgcac gagatcgtcg
    19081 accgttacat cgacttctgc gtcgccaatc cggagttccc cgccctgtgg atccaccggt
    19141 ggctgtacga cgcggccgac ctcaccggtc tggagcggca gtactcgcag ccgctgatca
    19201 ccatgacgac ctccgtactg gagcaggccg cggaggccgg gtacatcgac gactcggccg
    19261 acatggagta ctgcgtgtgg acgctgatct ggtgcgtgca cgggttcgtg cagggcggcg
    19321 tcctcgacga cgcgggcgat cggctggggg cggagaaccc cgaggtgctc gcccggttcc
    19381 ggcggcatct ccatcggctg gccgagcgga ctctgaatct ttcataggca tcctggtgat
    19441 atctcgctaa atcggaaaca cgctgtacac ctcgacgaaa cgaacccatg ttgggagcgc
    19501 tcccaatcgt gcacgccgag gagaagagaa agctatggga ccccgattga gttcctggcg
    19561 gagagtcatg atgatggcgg cggccatgct gctggccgtc accgggctcg ccgtcatgca
    19621 ggccccagcg ggcgctgccg tcgcatgcca ggtcacttac gccaaacagt gggacaacgg
    19681 cagtggtttt ggcgccaaca tcacgatcaa caatctcggt gacgcggtga acccgtggcg
    19741 gctcacgtac acgtggccgg ggaaccagac cattcagcag ggctggaacg ccacctggtc
    19801 ccagtcgggc cagaacgtga ccgtcgtggc accctcgtgg gcgggcaacc tgggcaccgg
    19861 ccagtcggtg cagatcgggt tcaatgggca ggtcagcggc accaacacca acccgacgtc
    19921 gttctccctg aacgggaccg tctgcaacgg tggcccgagc ccgtcgccgt cgccctctcc
    19981 gtcgccgagc ccgtcgccgc agcagcagtc gctgatcgtg acgccgacca gcgtgagcgt
    20041 ccccgagggc ggcaccgcca cctactcggt gcggctcaac cggcagccca cctccaacgt
    20101 gaccgtgagc accacggccg gcagcggtga caccaacctg acggtcagtt cgggcgccag
    20161 cctcacgttc accacctcca actgggccac cgcgcagaac gtgaccctgg ccgccgccca
    20221 ggacagcgac acgaccaacg gcacccgccc gttcaccgtc gcctccagcg gtctgaccag
    20281 cgtcacggtc aacgcgaccg aggccgacga cgacaccacg cagacccagt cgctggtcgt
    20341 ctcctcgacc gccgtgaccg tcaacgaggg cgggaccggc acctacaccg tccgcctcgc
    20401 gaccgcgccg agcggcaacg tgaccgtcac gaacaccgcc ggctccggtg acaccaacat
    20461 caccgtcagc tcgggcgcca gcctgacctt caccacgtcg aactggcaga ccgcgcagac
    20521 ggtcaccctg gccgccgcgc aggacagcga ctcgaccaac ggcacccgcc cgatcaccgt
    20581 cgcctcctcg ggcctgacca gcgtcacggt caccgccacc gagagcgacg acgacggcac
    20641 cccgccgccc ggccgcgtcg acaaccccta tgcgggtgcg gccggctatg tgaaccctga
    20701 ctggtcggcc caggccgcgt ccgagcccgg cggttcggcc gtcgcgaaca cctcgaccgc
    20761 catctggctc gaccggatcg ccgccatcac cagcggctcg gccggcagca acagcaaggg
    20821 cctgcgtgac cacctggacc tggccgtcgc tcaggacgcc gccaacggct ccacgccggt
    20881 gatcatccag gtcgtgatct acaacctgcc caaccgtgac tgctcggcgc tggcgtcgaa
    20941 cggtgaactg ctgatcgcgc agaacgggtt gaacaggtac aagaccgagt acatcgacgt
    21001 gatcgccggg atcatggccg acaccaagta cgccaacctg cggatcgccg cgatcgtcga
    21061 gatcgactcg ctgccgaacc tggtgaccaa cctcggtgtg gccaagtgcg cggaggccaa
    21121 gtcgaccggc gcctacgagc agggcgttgc ttacgcgctc ggcaagctgt acgcggtccc
    21181 gaacgtctac aactacgtcg acgccggtca ccacggctgg ctcggctggg acaccaactt
    21241 cggcccctcg gctgacctgt tcggctccac ggccgacctg gcgaccggtg gcaaggcgac
    21301 ggtgcacggt ttcatcacca acaccgccaa ctacagcgcg ctgaccgagc cgtacttctc
    21361 ggtcaacggc tcggtgaacg gccagcagat ccgccagtcg cgctgggtcg actggaactt
    21421 ctacatcgac gagctgtcct tcgcccaggc cttccgcacc cgcctggtcc aggagggctt
    21481 ctcctccaac atcggcatgc tgatcgacac cagccgtaac ggctggggcg gctcggcccg
    21541 tccgaccgcg gccagcacct cgaccgacct gaacaccttc gtcaacaact cgcgtgtcga
    21601 caagcgcatc cacgccggca actggtgcaa ccagagcggt gcgggcctgg gcgagcgtcc
    21661 gcgctcggct ccggcgtccg gtatcgacgc ctacgtgtgg gtgaagccgc cgggcgagtc
    21721 ggacggctcc tcgacgcaga tcgacaacaa cgagggcaag ggcttcgacc ggatgtgtga
    21781 cccgacgtac ggcggcaacg accgtaacgg caacagcgcg accggcgctc tggccaactc
    21841 gccgctgtcg ggccactggt tctcggcgca gttccgtcag ctcctcgcca acgcctaccc
    21901 gcccatcagt taattgagga cgtcgtggtc tcgccgaggt tgggggtcct cctcggcggg
    21961 accacggctt taccgcttta ccggctctac ggcaggtcga ggccgggttc ccggcagcgc
    22021 atcagcagca tggccgcgtc gtcggtcggg gggccgtcga tgtgggcgat cagatcgcgg
    22081 cgcagggact ccagcgccgc ctccgggtcg tcgtcgttga gcaggtggac ccggtcgtcc
    22141 agcggataga accggccgaa cgcgtcgcgg gcctcgatga cgccgtcggt gtagaagagg
    22201 atctggtcgc ccggttcgaa ggtgatcgtg tagggcgccg gaccctcggg ccccagaacc
    22261 gcgagcccca gcgggggaac atggtcatcg gggtcggcga actcgatctc cccgttggcc
    22321 cgcagcacca aaggcgccgg atggccgtag ttgaggagcg tcatcgtcgt ctcctccagg
    22381 ttgaactcgg ccagcacggc ggtgacgaac tcctcgcccg aaagacgccg gttgagcgcc
    22441 ttctccagct tggcgctcac gccctccagg tccttctcgt catgcgctgc ctcacggaag
    22501 gcccccagga ccagcgcggc cgtctcgacc gcctccagac ccttgccctg gacgtcgccc
    22561 acgatggccc tgactccggt gggggcgacg acgacctcgt acagatcacc accgatgtgc
    22621 gcgtcggcca tggccgacgt gtaggagacc gccacccgca tgtgcccggc ccgccggggg
    22681 acagggcgga gcagaacccg ctgcgcgacc tcggccaccg accggacctg cgccagttcc
    22741 cgttccctgc gccggcgtcc caccgtcgcc agggcgctcg ccgccgtgac accggcgatc
    22801 gaacccatgg tgatgtacgc cctgcgcagc tccagatggt tgtaagccga cagccccagg
    22861 gccaagacca gcgcggtcac cccgacgagc agggtccgcc ggatcccgcc ggtgagcgag
    22921 gcgaaggccg ggccgaccgc gagcaggggc aggaagccga tctccgggcc ggtgctcaga
    22981 tcgagcagcg tcaccaggag catcatgaga aacggcagca ccgcgagagc gaacgccgtg
    23041 cgggccccgg ccgctcggcg ccgccccttg cccggacgca acggtccggc gaggcgcaac
    23101 ggcatccggc gaatcccctc taatcccgtc tggttagcgc ttgcgaccat acttcacgat
    23161 ccggcctggg atgcgaagtc ataaaaacga gaggcgcccg catccacgtg gatacgggcg
    23221 ctcccaaaat gcgggttaga cgatcgaacc ggaccagacg ttcgccgcct gcttgtagac
    23281 gccgtaggtc tcgccgtcga agtaggcgga gaccgaggtg tcgatgcgtc ggttgccgtc
    23341 acggtcggag accgcgatgg tcacgccgtt caggtagccg agacggcggg tgttcttgta
    23401 gctcgccagc cacgaggagc cgatggcgcc c
//
