LOCUS       NZ_BBXD01000009        21068 bp    DNA     linear   CON 08-AUG-2024
DEFINITION  Herbidospora mongoliensis strain NBRC 105882, whole genome shotgun
            sequence.
ACCESSION   NZ_BBXD01000009
VERSION     NZ_BBXD01000009.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Herbidospora mongoliensis
  ORGANISM  Herbidospora mongoliensis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Herbidospora.
REFERENCE   1
  AUTHORS   Komaki,H., Ichikawa,N., Oguchi,A., Hamada,M., Tamura,T. and
            Fujita,N.
  TITLE     Genome-based analysis of non-ribosomal peptide synthetase and type-I
            polyketide synthase gene clusters in all type strains of the genus
            Herbidospora
  JOURNAL   BMC Res Notes 8, 548 (2015)
   PUBMED   26452464
  REMARK    DOI:10.1186/s13104-015-1526-9 Publication Status: Online-Only
REFERENCE   2  (bases 1 to 987199)
  AUTHORS   Hosoyama,A., Oguchi,A., Ichikawa,N., Kimura,A., Ohshita,R. and
            Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2015) Contact:Director-General Department Of
            Biotechnology National Institute of Technology and Evaluation,
            Biological Resource Center (NBRC); 2-49-10 Nishihara, Shibuya-ku,
            Tokyo 151-0066, Japan URL :http://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Noncontiguous Finished
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: newbler v. 2.6
            Genome Coverage                   :: 62x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001570545.1-RS_2024_08_08
            Annotation Date                   :: 08/08/2024 02:40:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,280
            CDSs (total)                      :: 8,202
            Genes (coding)                    :: 8,113
            CDSs (with protein)               :: 8,113
            Genes (RNA)                       :: 78
            rRNAs                             :: 4, 6, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 4, 5 (5S, 16S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 21 of 89
            Pseudo Genes (incomplete)         :: 71 of 89
            Pseudo Genes (internal stop)      :: 4 of 89
            Pseudo Genes (multiple problems)  :: 7 of 89
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:23:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 823955
            Orig. end                         :: 845023
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BBXD01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="5"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21068
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11068](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11068
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(750..1310)
                     /gene="pyrR"
                     /locus_tag="AW272_RS08075"
     CDS             complement(750..1310)
                     /EC_number="2.4.2.9"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131602.1"
                     /locus_tag="AW272_RS08075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="WP_157518430.1"
                     /transl_table=11
                     /translation="MTHAQNQVARAVLEGPDIHRALTRIAHEILERTRGASDVVLLGIP
                     TRGATLAHRLAERVAQFEGVKVPVGSIDITMYRDDLRLGPARPLGHTDVPAGGIDGKTV
                     VLVDDVLFSGRTVRAALDALNDIGRPKTVQLATLVDRGHRELPIRADYVGKNLPTAKSE
                     KVKVLLSEIDGRDAVELLKGAAR"
     gene            1701..2195
                     /locus_tag="AW272_RS08080"
     CDS             1701..2195
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622275.1"
                     /locus_tag="AW272_RS08080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcriptional regulator"
                     /protein_id="WP_066362246.1"
                     /transl_table=11
                     /translation="MPSDYAKSLGARLRAIRTQQGLSLHGVEEKSRGRWKAVVVGSYER
                     GDRAVTVQKLAELADFYGVPVSELLPGGAAPSPLLPTPKLVIDLERLGQLPKDKAGPLA
                     RYAQTIQSQRGDYNGKVLSIRQEDLRSLAVIYDRSPAELTEEFIAWGVLDAEARRAVES
                     F"
     misc_feature    2230..2243
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    2281..2296
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            2312..2527
                     /locus_tag="AW272_RS45970"
     CDS             2312..2527
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022684.4"
                     /locus_tag="AW272_RS45970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_066362247.1"
                     /transl_table=11
                     /translation="MRLSRAERRVLDEIAGHFRRSDPQLAQDLAEHGGEEREVPILPAF
                     MTGRPAMAVAGIVLVTAFLMPFIAIN"
     misc_feature    complement(2560..2574)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            2565..3788
                     /locus_tag="AW272_RS08090"
     CDS             2565..3788
                     /EC_number="3.5.3.6"
                     /GO_function="GO:0016990 - arginine deiminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006527 - arginine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889503.1"
                     /locus_tag="AW272_RS08090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arginine deiminase"
                     /protein_id="WP_066362249.1"
                     /transl_table=11
                     /translation="MTFTVASEVGHLHHVLLHAPDLALKRLTPTNMADLLFDDVLWVAR
                     AVEEHEEFQTVLRDRGVRVTLLHDLLRETAEIPEARKHILDGGVDDRFIGPMAADEIRN
                     ALDSLDPASLASHLTGGLTKRETLELGCDPKSLVFHSLDPDDFVLPPLPNHLYTRDTSC
                     WIYDGVSINAMRKRARRRETVNMEAIYRFHPMFAEEHFGVWYPGTSMAPATVEGGDVLV
                     IGRGAVLVGMSERTQPQAVEMLAKNLFAAGSASVIVALRLPQTRAFMHLDTVMTNVDVG
                     VFTKYAGLGMLPSYTIEPGDTEKELKVTDHAPEDMHRAIARALGLDDIRVLTPTQDVHA
                     AEREQWDDGCNVLAVEPGVVIGYERNTTTNNFLRANGVEVITIRGSELGRGRGGPRCMS
                     CPLHRDGI"
     gene            3842..4726
                     /locus_tag="AW272_RS08095"
     CDS             3842..4726
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012791.4"
                     /locus_tag="AW272_RS08095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="universal stress protein"
                     /protein_id="WP_066362251.1"
                     /transl_table=11
                     /translation="MNILTGYTPDLRGRDALALTGVISTALSARVTVANVRPATWETPG
                     PGKVDAEWKAYLRAQQESAMSAAARAAEESGLSDVEAATTAHHSSGLGLIRLSSQEDCD
                     LIVIGSAPHGPHDRIAVGSTADQLLHCSRSPVGIAPKGYSIDPPTTLTRLTFAYFKSPT
                     CEDALLLAIRAAGKLQLPLRLISVLLKERGTARVEEDVLEEVHAQYERDLRAAVRGPRR
                     TAALHQGVSTEVVAGPNASKALAETAWIPGELMVCGSSSAGPLRRVFVGDMSLKILRAA
                     PCPVVVLPRSVTH"
     gene            complement(4762..5325)
                     /locus_tag="AW272_RS08100"
     CDS             complement(4762..5325)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895574.1"
                     /locus_tag="AW272_RS08100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="WP_066362253.1"
                     /transl_table=11
                     /translation="MTRIGIILGSTRPGRNGEQVARWVLEHASQRTDATFEIIDLLDYP
                     LPHFDEPMSPAMGQYQNAHTKEWAAKIASYDGFVMVTPEYNHSTSGVLKNAIDYLFAEW
                     NNKAFGVVSYGGVGGARAAEHLRLIGGELKMADVRTNVALSLFTDFQEFSKIAPSDYQV
                     ATLTTLLDEVVSWSRALAPLRQTA"
     gene            complement(5463..5810)
                     /locus_tag="AW272_RS08105"
     CDS             complement(5463..5810)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133773.1"
                     /locus_tag="AW272_RS08105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_245657269.1"
                     /transl_table=11
                     /translation="MFRSVLDRVGDKWSLILIGLLDTGSMRFTELLRTTPGISRRMLTL
                     TLRNLERDGIVKRTVYPEIPPRVEYEVTAFGHTLTPPVLGLARWAAENQDAIVAHRRAY
                     DEAAGDLDDVE"
     misc_feature    complement(5798..5812)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.35"
                     /tool="antismash"
     gene            complement(6003..6464)
                     /locus_tag="AW272_RS08110"
     CDS             complement(6003..6464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131600.1"
                     /locus_tag="AW272_RS08110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_066362255.1"
                     /transl_table=11
                     /translation="MTGPQQNGHGAAPTGPASGPKVSRTVLAHLTDARACLASAALAGN
                     PADRYIHAHMAALRSAAAILAARPQPIDGRRRRLRSAWELLPEVQPELSQWAAYFAVSA
                     KKRAAAEAGLVHLVSAHDAEELIAEATAFVTIIESTLGVTSQETLPMAG"
     misc_feature    complement(6692..6707)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.49"
                     /tool="antismash"
     misc_feature    6693..6706
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.0"
                     /tool="antismash"
     misc_feature    6730..6745
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.56"
                     /tool="antismash"
     gene            complement(6803..7585)
                     /locus_tag="AW272_RS08115"
     CDS             complement(6803..7585)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889495.1"
                     /locus_tag="AW272_RS08115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="L,D-transpeptidase family protein"
                     /protein_id="WP_066362256.1"
                     /transl_table=11
                     /translation="MGVRQHLAVAAAMLTAGAVLAISPPAMAAPVTVQQLAQTVRTAPD
                     WVSPGKTLKFGAKGSVVKSLQARLKALGYMPGSVDGQYGGATQTAVWAFQKVNGIKPTS
                     TIVARTWRALENPKLPKVLVPTGKPTRAEVNLSTQILVLYVKGQIKLISHISSGSGIPY
                     VEYATWNGTRQKFSGDARTPTGTFKTTWRRTGWHKSYLGELYNPIFFNGGIAFHGALSV
                     PLYPASHGCVRLPMHVAKVLPGLLGTGVPVIVRGSFQR"
     gene            7719..8195
                     /locus_tag="AW272_RS08120"
     CDS             7719..8195
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131598.1"
                     /locus_tag="AW272_RS08120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_066362258.1"
                     /transl_table=11
                     /translation="MPEKLPPSAVHIAGILRAHGATGEIVLFEEATPTAATAAAQLGCE
                     VGAIANSLVFDADGAPLLVLTSGAHRVDTGLVASLIGVAKVRRATPEFVREHTGHPIGG
                     VAPIGHPAPVRTLVDTWLGKHPVVWAAAGHPHTIFPTTFDELVALTGGTPADVA"
     gene            8214..8768
                     /locus_tag="AW272_RS08125"
     CDS             8214..8768
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541677.1"
                     /locus_tag="AW272_RS08125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_066362259.1"
                     /transl_table=11
                     /translation="MIEMRRVGPQSFASELRTVLGIYTAAMHPPPDQLSGRLAIMRNHT
                     TYPVFAGVLATTETGEIAGFAYGFHGAHGQWWHDVVKRSLFERAGPLVADDWFGDALEL
                     AEIHVHPDHQGKGVGRRMIHTMCEGRPERTAVLSTHDAPTAARHLYASLGFYDLMTAFA
                     FPGGSELYAIAGARLPLIQPA"
     gene            complement(8951..9871)
                     /gene="metF"
                     /locus_tag="AW272_RS08130"
     CDS             complement(8951..9871)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131596.1"
                     /locus_tag="AW272_RS08130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_066362262.1"
                     /transl_table=11
                     /translation="MALGLPSRFPDRVATVKELLAAGERSFSFEFGPPKTPEAERNLWR
                     VIRELESLKPTFVSVTYGAGGSTRDRTVEIVERIAHSTTLTPVAHFTAVDHSTRELRHL
                     IGRFADAGVRNILAVRGDPPGDPMGEWVAHPEGVHYAEDLVRLIRQSGEFCVGVAAFPY
                     KHPRSPSIESDVDFFVRKCRAGADYAITQMFFEADDYLRLRDRVAAAGCDTPIIPGIMP
                     VTKFGTIARSEQLSGAPFPAKIAARFEKVKDDPDAVYQLGIEHGVELCRRLLDEGAPGI
                     HFITFNRSNATREVYQALMPAVPLA"
     misc_feature    complement(9916..9934)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.99"
                     /tool="antismash"
     gene            10001..11068
                     /locus_tag="AW272_RS08135"
     CDS             10001..11068
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617050.1"
                     /locus_tag="AW272_RS08135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_066362607.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.1e-50, bitscore:
                     166.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNATAPLEFIRPEVDRALKRFIDRHRMAFDDPDLAVVLGAVQDF
                     LTGGKRLRPAFCYWGWRAAGGADDPSVISAAAALELLQASALVHDDVMDSSDMRRGMPS
                     AHRRFEKLHVDSGWHGSAVQFGEGSAILVGNLLLIWSGELWRTSGVASEGLAAAQPVFD
                     HMLTELMNGQYLDLLAQAHGENSFESARRVALFKSGKYSVEHPLRLGMTLATQSREGWI
                     DQVCAGYGQNVGIAFQLRDDVLGVFGDPAETGKPAGDDLREGKRTMLIARTLELASPAQ
                     TQSVRALVGDPKLDAEGVEALRGVIVDTGALASVEELITTYVTEALAVLDAAPIEAEAR
                     EALKALAIAATTRRN"
     gene            complement(11065..11724)
                     /gene="thiE"
                     /locus_tag="AW272_RS08140"
     CDS             complement(11065..11724)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291493.1"
                     /locus_tag="AW272_RS08140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_066362263.1"
                     /transl_table=11
                     /translation="MTDPSRRRLADSRLYLCTDGRRERGDLVEFLDAALSGGVDVVQLR
                     EKGLEAREELALLEVFRAVCDRHGALLSVNDRADVAYAARAAGFGPDVLHLGQDDLPVS
                     IARAMLGEEIVIGRSTHSFDEASAASAEPGVDYYCCGPTWPTPTKPGRPAPGLPLLAHA
                     SGLPAERPWFAIGGIDLGNFDEVLAQGATRVVVVRAITEAEDPKAAAQELSRRLGV"
     gene            complement(11746..12120)
                     /locus_tag="AW272_RS08145"
     CDS             complement(11746..12120)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541673.1"
                     /locus_tag="AW272_RS08145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_066362264.1"
                     /transl_table=11
                     /translation="MTLTVAQIDRDTDQLVGEWLPLSDVAKKLQLSIGRAKQLIKDRKL
                     VGARRGGGEPQIPAVFIAGDDVIKGLPGTLTVLSDAGFSEVECIRWLFTPDESLPGAPI
                     DLLTAGRHTEVKRRAQALGF"
     gene            complement(12164..13333)
                     /locus_tag="AW272_RS08150"
     CDS             complement(12164..13333)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889487.1"
                     /locus_tag="AW272_RS08150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_066362265.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.4e-52, bitscore:
                     172.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDHVVVVGAGLAGVRSVEALRAHGYQGRITLVGDEPHRPYDRPPL
                     SKAVLLGDADSTVVDSDLEALNVRLMLGTAAKGLREGVLSTTDGELSFDGLVVATGASP
                     IRLRGEGHQHVLRTIDDALALRASLTEGARVAVIGAGWIGAEVATAAAKAGCQVTVVEA
                     GEAPVATALPIGRYMIPWYAEAGIELLLDATVGTVDPDGLTLMNGDRIPADVVVTGVGV
                     RPNVAWLDGSDVELDNGVLVDEHLRSFSPNVVAVGDCANWYSRRFGRRMRVEHWDTALG
                     APDTAAATLMGENAIYDPVPYFWSEQFGRMVQYAGHHHGANLVLRGDPETDAKWAACWL
                     TADHRLTAILTVDRPRDLVQGRRLVEGRQRLDAGRLADPSVTLRDCTVA"
     misc_feature    complement(13274..13276)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(13432..13450)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    complement(13435..13450)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.56"
                     /tool="antismash"
     regulatory      13458..13572
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            13561..14622
                     /gene="thiO"
                     /locus_tag="AW272_RS08155"
     CDS             13561..14622
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084040.1"
                     /locus_tag="AW272_RS08155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_066362608.1"
                     /sec_met_domain="DAO (E-value: 3.4e-74, bitscore: 246.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNASDVFVIGGGIAGLSIAWRAASRGLTVTLADPDPGSQATRASA
                     GMLAPVSEVTYTEEPLLRLGLASLERWPEFAAELEEKSGVPVDLRSDGTVEVAYDADDL
                     AQLDELAAFEEKLGLRVERLTGRQCRQAEPMLSPNVRGGLLARDDLWVNPRRVTQALQK
                     AFQNAGGKIVKEHVTTLDGIEADQIVVAAGAWTPSLLPGLPVRPVKGQILRLRGPRGFL
                     QKCVRGRVRGSDVYLVPRDDGEIVVGATMEELGFDTRVTAGGVYELLRDARELVPGITE
                     LDLAETFAGLRPGTPDNLPYVGRHGDVWVAAGHHRAGVLLAPLTAEAVVACLHGEANPM
                     PECDPSRLDTERI"
     gene            14623..14823
                     /gene="thiS"
                     /locus_tag="AW272_RS08160"
     CDS             14623..14823
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565075.1"
                     /locus_tag="AW272_RS08160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_066362266.1"
                     /transl_table=11
                     /translation="MRITINGDPHDLDDGSTLTKAVQTLTRQPTGIAVAVNDEVVSRGA
                     WDATPLTEGDRVEVLTAVQGG"
     gene            14830..15600
                     /locus_tag="AW272_RS08165"
     CDS             14830..15600
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541669.1"
                     /locus_tag="AW272_RS08165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazole synthase"
                     /protein_id="WP_218010815.1"
                     /transl_table=11
                     /translation="MDDPLLIGGEEFASRLIMGTGGAPSLEVLDRALVASGTELTTVAM
                     RRLDPGARGSVLDVLRERGIKVLPNTAGCFTAGEAVLTARLAREALNTNWVKLEVIADE
                     RTLLPDPIETFDAAERLVADGFVVLPYIGDDPILARRLEQAGCAAVMPLGSPIGSGLGI
                     RNPHNIELIVESAQVPVILDAGIGTASDAALAMELGCSAVLLATAVTRARKPDLMAAAM
                     RGAVEAGRRAFLAGRIPRRRYAEASSPGRPFQDG"
     gene            15673..17595
                     /gene="pknB"
                     /locus_tag="AW272_RS08170"
     CDS             15673..17595
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131588.1"
                     /locus_tag="AW272_RS08170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_066362269.1"
                     /sec_met_domain="Pkinase (E-value: 1.4e-52, bitscore:
                     174.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTTLSDPLVGHVLDGRYRVESRIARGGMASVYLALDVRLDRMVA
                     IKVMHRSLAEDPEFVRRFIGEAKSVASLSHPNIVHVFDQGTDGDHVYLSMEYFPGKTLR
                     AVLDERGPLAPREALEIMIPVLAALGSAHQAGLIHRDVKPENVLMTEDGRVKVVDFGLV
                     RAIEGGNQTRSGVMIGTVGYMAPEQVTSGQADVRSDVYSAGIMLFELLTGRQPFGGESP
                     VSVAYRHVHESIPAPSSFSYDIPPSLDALVAKATAKEPADRNHDANAMLVAAVEVHRTL
                     PQTSTGRHSVPPRQQSAEQAFFSGSHTMIQPAIEVPPTRPPRAAVRRGFRVNWFIVALA
                     VLMVGGIAFSGWYFTLSRTAIVPDLVKRNIEAARQLAESNGFTIKIGEGRFDAKVPKDM
                     VLETSPLKGVEAERGSVITIIASRGPEMVGVPKTEGMTEADARVAMSDAGLNVSRIRRT
                     PSDKIGRGLVIKTDPVVGKKVEKGSNVILAISMGLLMPSVVDLPRDQAEALMRENGFDP
                     SCINEVVDEKPGNTVIAQEPAAGAEVDKGARVCLTVSRGPDTGWQWPWEQDPSVAAPDF
                     VNVPDVRFKNVEEAKRELQAAGFKVQVHKLFSRGRPGGDGPGQRVRGQNPLGQVPAGST
                     INLWF"
     misc_feature    17452..17454
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17609..18550)
                     /gene="alc"
                     /locus_tag="AW272_RS08175"
     CDS             complement(17609..18550)
                     /EC_number="3.5.3.4"
                     /GO_function="GO:0004037 - allantoicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132824.1"
                     /locus_tag="AW272_RS08175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="allantoicase"
                     /protein_id="WP_066362273.1"
                     /transl_table=11
                     /translation="MTFRHLPDLAVRGLGGSVIAANDEAFADRQALIRPHPALFHTHDF
                     GAKGQIYDGWETRRRRTTGHDWAIVRLGLPGVIHGLVIDTAWFKGNYPPYASVEACTAD
                     EPLAHEELTGWTEILPRSPLGGDREHEFAVDDPNRYTHVRLNIYPDGGVARLRVHGEVV
                     PDPAFLHGLTVDLAALANGALVIDCSNQFYSSPNNVIAPGLARHQAEGWETARRRDDGN
                     DWLVVRLAGRGTVTVAEIDTTHLVFNAPGWVSLSGRDGDGDWFSLLGKTRLQPDAPHRF
                     RLDSDRPVTHVKCDIYPDGGLARLRLLGDLLS"
     gene            complement(18547..19833)
                     /gene="allB"
                     /locus_tag="AW272_RS08180"
     CDS             complement(18547..19833)
                     /EC_number="3.5.2.5"
                     /GO_function="GO:0004038 - allantoinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0050897 - cobalt ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="allB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017579617.1"
                     /locus_tag="AW272_RS08180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="allantoinase AllB"
                     /protein_id="WP_066362274.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.6e-30, bitscore:
                     102.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVLVRSRRVVTPEGVLPLGVDVVDGRIAGLVPYTTHEGLDLGDV
                     ALLPGLVDTHVHINEPGRTHWEGFATATRAAAAGGVTTVVDMPLNSLPPTTTVPNLEIK
                     KKAAYGQIAVDVGFWGGAIPGNLGDLRPLWDAGVFGVKCFLSPSGVDEFPALDANGLTR
                     ALQELARFDGLLIAHAEDPWTLTEPTGPSYSEFLDSRTQEAEVRAIETVIAVARETGAR
                     AHIVHVSAGDAIAVLREAQAQGVRITAETCPHYLTLSAEEVTGTAFKCCPPIREAANRD
                     ALWAGLADGTLMGIVSDHSPCPADMKGLDSPDFVTAWGGISSLQLGLPAIWTEASARGF
                     SLEDVVRWMARGPADFAGLSSKGRIEVGADADLVAFDPEAGFVVEAGDLAHKNPVTAYQ
                     GRSLKGVVQQTWLRGDAPGHGRFLTRGAR"
     gene            complement(19830..20969)
                     /locus_tag="AW272_RS08185"
     CDS             complement(19830..20969)
                     /EC_number="2.7.1.31"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631478.1"
                     /locus_tag="AW272_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycerate kinase"
                     /protein_id="WP_066362275.1"
                     /transl_table=11
                     /translation="MRDHIVIAPDKFKGSLTAPEVAHHVAAGLGDVPVVLLPVADGGDG
                     TVDAVAACGFTRVEVEVTGPTGQPIRASYAVRDDTAVVEMAEASGLRRLPGGLEPLTAS
                     SYGTGELIAHALAQGATRIVLGLGGSACTDGGTGLARALGARFLDDEGAELPLGGGSLK
                     DLAKIDLSGFDAGSADYVVASDVDNPLLGPHGAATVYGPQKGASPDQVKLLEAGLSRLA
                     AVAVHTHGLTGSIEHDGIVRAMGVAGQPGAGAAGGVGFAALAFLKASIRPGIAYLLGLL
                     DFETHIEGARLVITGEGSLDEQSLRGKAPVGVANAAMRHGVPVIAVCGRREVSDDDLRK
                     AGIEAAYALTDIEPDPARCMAEAGPLLERLVASVVKERV"
ORIGIN
        1 gtggagcttg gcgaagcggt cgcggtcgag gccgtagcgg cggctgtact cgcgcgcgct
       61 ggggaagtag gccgcgttca tgcgttcgag ctgcacgcgc agcatcatca cgacgtcggc
      121 cttgggcagg acggcgtcga ggtcgtagga cacctggcac ggccagcgct ccaccgagac
      181 cggcagcagc gtcggcggcg cgaccagcgt cacctcggcg ccgagggtgg cgagcagcag
      241 cacgttcgac cgggcgaccc tgctgtgcag gatgtcgccc acgatcgcga ccttgaggcc
      301 ttcgaggcgg cccaggcgct gccgcatcga gaaggcgtcg aggagcgcct gggtggggtg
      361 ctcgtgggtg ccgtcgccgg cgttcagcac gctcccccgt acccagttgg cgagccggtg
      421 gggcgcgccg gaggccgggt ggcggatgac cacggcgtcg gcgcccatgg cctggagggt
      481 gagcgcggtg tccttgagcg actcgccctt ggagacgctc gaccccttgg cggagaagtt
      541 gatcacgtcg gccgacaggc gcttggcggc ggcctcgaag gagatccggg tgcgggtgga
      601 gtcttcgaag aacaggttca ccacggtacg gccgcgcagc gtcggcagct tcttgatgga
      661 gcgttcggag acccgggcca gttcctcggc ggtgtcgagg atgagcaggg cctcgtcgcg
      721 ggagaggtct ccggcggaga tcaggtgctt cacctggccg ctcccttcag cagttcgacg
      781 gcgtcgcgcc cgtcgatctc ggagagcagg accttgacct tctcgctctt ggcggtcggc
      841 aggttcttgc cgacgtagtc ggcccggatg ggcagctcgc ggtggccgcg gtcgaccagg
      901 gtggcgagct gcacggtctt cggacggccg atgtcgttga gcgcgtcgag ggcggctctg
      961 accgtacggc cggagaagag cacgtcgtcg accaggacga cggtcttgcc gtcgatcccc
     1021 ccggccggga cgtcggtgtg cccgagcggg cgggccgggc cgaggcggag gtcgtcgcgg
     1081 tacatcgtga tgtcgatcga accgaccgga accttcacgc cctcgaactg ggcgacgcgc
     1141 tcggcgagcc ggtgggcgag agtggcgcca cgggtgggga tgccgagaag gacgacgtcg
     1201 gaggcgccac gggtccgttc gaggatctcg tgggcgatcc gggtgagcgc ccggtggatg
     1261 tcgggccctt cgagcacagc cctggcgacc tgattttggg catgcgtcat cggatagttc
     1321 accgcctttc ccgcctcaca ggacgggtct taaaagggtg tctggccacc gaaaccctac
     1381 caggccccct gcctctgcca gcgaggacgg gtcccatggc aggtaggagg ccgaccgcag
     1441 ctcagcgccc gaaatccgaa ggatgttcgg ttcccgccga gagcacggtt tcgccatctt
     1501 ttcccaatcg acttgacctt tgactgtgac ggctttaccg tcactgtccg taaccacaac
     1561 tctcgacctt cctgggtaaa tcccgacgca acggtcacgg ttggtacctg cccccaggta
     1621 ccgcacccgg tgaaccgggc atacgggacg tgggcacaca atcaagtaag aacagacata
     1681 gagagccggg ggcccaaacg atgccgtctg actacgccaa gtcgcttggt gcgcggctgc
     1741 gcgcgatccg aacacagcag ggtttgtcgc tgcacggggt ggaggagaag tcccgcggcc
     1801 gctggaaggc cgtcgtggtg ggctcctacg agcgtggcga ccgtgcggtg accgtgcaga
     1861 agctcgccga gctggccgat ttctacgggg tgccggtgtc cgagctgctt cccgggggcg
     1921 ccgcgccctc accgttgctg cccacgccca agctggtgat cgaccttgag cgccttggcc
     1981 agttgccgaa ggacaaggcc ggcccacttg cccgttacgc gcagacgatc cagtcgcagc
     2041 gtggtgacta caacggcaag gtgctgagca tccgccagga ggacctgcgc tcgctcgccg
     2101 tcatatacga caggtccccg gccgagctga ccgaggagtt catcgcctgg ggcgtcctcg
     2161 acgccgaggc acgccgcgcc gtcgagtcgt tctgacccca cgatcacccc ttccagcgag
     2221 ccggggtgat cgtggcaggt caaagtctgg tcatttcgga caaagaacgc taaaacttcc
     2281 ttcacggttt caccacctgg aggaagatca catgaggctg tcccgggccg agcggcgcgt
     2341 tctcgacgag atcgcgggcc acttccgccg gagcgacccc cagctcgccc aggacctggc
     2401 cgagcacggc ggcgaagagc gggaagtccc gatcctcccg gccttcatga ccggtcgccc
     2461 cgccatggct gtggccggaa tcgtgctggt tactgccttt ttgatgcctt tcatcgcgat
     2521 caactagcgt ttgaccatat tcggtgacgg gcaggtcgcc ggacatgacg ttcaccgtcg
     2581 cctccgaggt cgggcacctc caccacgtgc tgctgcacgc ccccgacctg gcgctgaagc
     2641 ggctcacccc cacgaacatg gccgatctgc tcttcgacga cgtgctgtgg gtggcgcggg
     2701 cggtcgagga gcacgaagag ttccagacgg tcctgcgtga ccggggcgtc cgggtcaccc
     2761 tgctgcacga tctgctccgc gagaccgccg agatccccga ggcccgcaag cacatcctcg
     2821 acggcggcgt cgacgaccgg ttcatcggcc cgatggcggc cgacgagatc cgcaacgccc
     2881 tcgactccct ggatcccgcg tccctggcct cccacctcac cggcgggctg accaagcggg
     2941 agaccctcga gctcggctgc gacccgaagt cactggtctt ccattcgctc gatcccgacg
     3001 acttcgtgct gccgccgctg cccaaccacc tctacacgcg cgacacgtcg tgctggatct
     3061 acgacggcgt ctcgatcaac gcgatgcgca agcgggcccg gcgccgcgag acggtcaaca
     3121 tggaggcgat ctaccgcttc cacccgatgt tcgccgagga gcacttcggg gtctggtatc
     3181 ccggcacgtc catggccccc gccaccgtcg agggcggcga cgtcctggtc atcggccggg
     3241 gggcggtgct ggtcgggatg agcgagcgca cccagccgca ggccgtcgag atgctcgcca
     3301 agaacctgtt cgcggccggt tcggcctcgg tgatcgtggc gctgcggctg ccgcagacgc
     3361 gcgcgttcat gcacctcgac acggtgatga ccaacgtcga cgtcggggtg ttcaccaagt
     3421 acgcggggct ggggatgctg ccgtcgtaca cgatcgagcc cggtgacacc gagaaggagc
     3481 tgaaggtcac cgaccacgcg ccggaggaca tgcaccgggc gatcgcccgc gccctcggcc
     3541 tcgacgacat ccgggtgctg accccgaccc aggacgtgca cgccgccgag cgcgagcagt
     3601 gggacgacgg ctgcaacgtg ctggccgtcg aacccggcgt ggtcatcggg tacgagcgca
     3661 acaccaccac caacaacttc ctgcgcgcca acggggtcga ggtcatcacg atccgcggca
     3721 gcgagctggg ccggggccgg ggcggcccgc gctgcatgag ctgcccgctg caccgcgacg
     3781 ggatctgatc cgccgtggcc gcccgcatgc cccgcaccga gccgaccgga ccgaagccgg
     3841 catgaacatc ctgaccggat acacgcccga cctccgtggc cgcgacgccc tggcgctgac
     3901 cggcgtcatc tcgacggccc tgagcgcgcg cgtgaccgtg gcgaacgtcc gcccggcgac
     3961 gtgggagaca cccggccccg gaaaggtcga cgccgagtgg aaggcctacc tgcgggccca
     4021 gcaggagtcg gcgatgtccg ccgccgcccg cgccgccgag gagtcgggcc tgtcggacgt
     4081 cgaggcggcc accacggccc accacagcag tggcctgggc ctgatccgcc tgtcctccca
     4141 ggaggactgc gacctgatcg tcatcggctc ggccccccac ggcccgcacg accgcatcgc
     4201 cgtgggcagc acggccgacc agctcctgca ctgctcccgg tcccccgtgg gcatcgcgcc
     4261 gaagggctac tcgatcgacc cgccgacgac cctgacccgc ctcaccttcg cctacttcaa
     4321 gtctccgacc tgcgaggacg cgctcctgct ggccatccgg gcggcgggca agctccagct
     4381 cccgctgcgc ctgatctccg tgctgctgaa ggaacgcggc acggcccgcg tggaggagga
     4441 cgtgctggag gaggtccacg cacagtacga acgcgacctc cgggccgccg tccggggacc
     4501 tcggcggacc gccgccctcc accagggggt cagcaccgag gtcgtggccg ggccgaacgc
     4561 gtcgaaggcg ctggcggaga cggcgtggat cccgggggag ctcatggtct gcggctccag
     4621 ctcggcgggg ccgctgcgcc gggtgttcgt cggcgacatg tcgctgaaga tcctccgggc
     4681 ggcgccgtgc ccggtggtgg tcctcccccg ctcggtgacc cactagcttt ccgccgagca
     4741 ggggttcgcg tcatgccctc ttcaggcggt ctggcgcagc ggggccaggg cgcggctcca
     4801 ggagacgacc tcgtcgagca gggtggtgag ggtcgccacc tggtagtcgc tgggcgcgat
     4861 cttgctgaac tcctggaagt cggtgaacag cgacagcgcc acgttggtcc gcacgtcggc
     4921 catcttgagc tcgccgccga tcaggcgcag gtgctcggcc gcccgagcgc cgccgacccc
     4981 tccgtacgac acgacgccga aggccttgtt gttccactcg gcgaacaggt agtcgatcgc
     5041 gttcttgagc acccccgacg tcgagtggtt gtactcgggc gtcaccatca cgaagccgtc
     5101 gtaggacgcg atcttggcgg cccactcctt ggtgtgggcg ttctggtact ggcccatggc
     5161 cggcgacatg ggctcgtcga agtgcgggag cgggtagtcg agcaggtcga tgatctcgaa
     5221 cgttgcgtcg gtacgctgcg aggcgtgttc cagcacccac cgggcgacct gttcgccgtt
     5281 gcggccgggc cgggtgctgc cgaggatgat gccgatgcgt gtcatgaagg ggtcctctcg
     5341 cggaagaaag cggcgaggcg tcagtggagc gagcccgcca cctgctcagt aactaatgag
     5401 tactgagtac acgccggtaa ccggtaactt caactgaacc cagtaacacc gaggggaccg
     5461 actcactcga cgtcgtcgag atcaccggcg gcctcgtcgt aggccctgcg gtgggcgacg
     5521 atcgcgtcct ggttctcggc ggcccatcgg gccagcccga ggacgggcgg ggtgagggtg
     5581 tggccgaacg cggtgacctc gtattcgacc ctgggcggga tctccgggta gaccgtccgc
     5641 ttgacgatcc cgtcgcgttc gaggttacgc agcgtcaaag tgagcatccg gcgggagatg
     5701 ccgggagtcg tccgcagcag ctcggtgaat cgcatcgacc cggtgtcgag caggccgatc
     5761 aggatcaggc tccacttgtc gcccacccgg tcgagcacgg aacggaacat ctccggatcg
     5821 tgctccagac acatccggcc catcgaacgc atgacccgat ccgcatcggc ctgatgagac
     5881 acgtcaccac ccccgccgtc acccgaagat gacctggtct cttgtcggtt accgaagata
     5941 acccacaggg cggcggggag ccgcgtccgg atgcggcggg gaaacgcatc cggacgcctc
     6001 ggctaccccg ccatgggcag ggtctcctgg gaggtcacac cgagggtgga ctcgatgatg
     6061 gtcacgaagg ccgtcgcctc ggcgatgagc tcttccgcgt cgtgggcgct caccaggtgg
     6121 accagcccgg cctcggccgc ggcgcgcttc ttggcgctga cggcgaagta ggcggcccac
     6181 tgggacagtt cgggctggac ctcgggaagg agctcccatg cgctgcgcag gcggcggcgc
     6241 cggccgtcga tcggctgggg gcgcgcggcg aggatggccg cggccgagcg gagagcggcc
     6301 atgtgggcgt ggatgtagcg gtcggccggg ttgcccgcca gtgccgcgga ggcgaggcag
     6361 gcgcgtgcgt cggtgagatg cgcgaggacg gtccgcgaca ccttggggcc gctggcgggc
     6421 ccggtcgggg ctgccccgtg tccgttctgc tgcggtccgg tcatggtggt tcggcctcct
     6481 aaacgagtgg ccaccggcgg tctcatcacc ggtcagggtc aacagtcgca gaccccaccg
     6541 acatttccgc cggatcggtc agccggacga ggagcttccc ctctccccgt ccggcccgaa
     6601 gctgtggggc cgcggcaccc gtccttccgc cgatggcgga tgccgggacc cacgaggtga
     6661 gagcgagccg cgagtcccac tctcaccttc atcgaacata gattcgaccc acaccaaagt
     6721 caagaatgtt cgaaagcccg ttcgacacag gcccgaggaa aagaaaaagg ccccgccgga
     6781 gcgaggcctt tccggacaac cgtcagcgct ggaaactgcc gcgcacgatg accggcacgc
     6841 ccgtgcccag gaggccgggg aggaccttcg ccacgtgcat cggcaggcgc acgcagccgt
     6901 gcgacgccgg gtagaggggg accgacagcg cgccgtggaa ggcgatgccg ccgttgaaga
     6961 agatcgggtt gtagagctcg cccaggtagg acttgtgcca gccggtacgc cgccacgtcg
     7021 tcttgaacgt ccccgtcggg gtccgcgcgt cgccgctgaa cttctggcgg gtgccgttcc
     7081 aggtcgcgta ctccacgtag gggatgccgc tgcccgacga gatgtgcgag atgagcttga
     7141 tctggccctt cacgtacagg accaggatct gggtcgacag gttgacctcg gcgcgggtcg
     7201 gcttgccggt cgggacgagc accttcggca gcttcgggtt ctccagcgcc cgccacgtcc
     7261 tggcgacgat ggtgctggtc ggcttgatgc cgttgacctt ctggaaggcc cagaccgccg
     7321 tctgcgtggc gccgccgtac tgaccgtcga cgcttccggg catgtagccc agcgccttca
     7381 ggcgggcctg caggctcttg acgacgctgc ccttcgcgcc gaacttcagt gtcttgcccg
     7441 gcgagaccca gtcgggcgcg gtccgcaccg tctgggcgag ctgctgaacg gtcaccggtg
     7501 ccgccatggc cggtggtgag atcgcgagta cggcccccgc cgtgagcatc gcggcggcga
     7561 cagccagatg ctgccgaacc cccatggtta ccaacccctc caaaagtgca caaagctcag
     7621 gtcaatggac cataacccag aggccgattg gtccatatgg ggggcatggt gtcgttatca
     7681 acacgccatg tcccatccga tctgtttaga gttggcgcgt gccagaaaag ttgccgccga
     7741 gtgccgtcca catcgccgga atcctccggg cccacggggc caccggtgag atcgtcctgt
     7801 tcgaggaggc gacgccgacc gccgcgacgg ccgccgccca gctcgggtgt gaggtcggcg
     7861 cgatcgccaa cagcctcgtc ttcgacgccg acggcgctcc cctgctggtg ctcaccagcg
     7921 gcgcccaccg cgtcgacacc gggctggtgg cgtcgttgat cggggtggcg aaggtgcggc
     7981 gggcgacgcc cgagttcgtc cgagagcaca ccgggcaccc catcggcggg gtggccccga
     8041 tcgggcatcc ggcgccggtg cgcaccctgg tcgacacgtg gctcggcaag cacccggtcg
     8101 tctgggccgc ggcggggcat ccccacacga tcttcccgac gacgttcgac gagctcgtcg
     8161 ccctcaccgg gggtacaccc gccgacgtgg cctgatcggc tagggtgcgg aggatgatcg
     8221 agatgcgccg ggtggggcct cagagcttcg cctcggaact gcggacggtc ctgggcatct
     8281 acacggccgc catgcacccg ccgcccgacc agctgtcggg acggctggcc ataatgcgca
     8341 accacacgac atatccggtg ttcgccggcg tgctggccac cacggagacc ggcgagatcg
     8401 ccgggttcgc ctacggcttc cacggcgccc acggccagtg gtggcacgac gtggtcaaac
     8461 ggtcgttgtt cgaacgggcc ggcccgctgg tggccgacga ctggttcggc gacgcgctgg
     8521 agctggccga gatccacgtc caccccgacc accagggcaa gggcgtcggc cggcggatga
     8581 tccacacgat gtgcgagggc cgccccgaac gcaccgcggt cctgtcgacc cacgacgccc
     8641 ccaccgcggc ccgccacctc tacgcgagcc tcggcttcta cgacctgatg accgccttcg
     8701 ccttccccgg cggctcggag ctctacgcga tcgcgggcgc cagactcccg ctcatccagc
     8761 ccgcctagtc agccggactc aaaagctctt ttttccgtta cggctccgcc tggccggccc
     8821 cgcccaccgc gcccgcaccg gccccgtatc cggcgccgac cacccgctcc cgcaccccgc
     8881 cgcgacgacg gcggtccaac cgagaaccgg cgcctggcag gcctcgccag gcgccggtca
     8941 gagccctgtc tcaggccagc gggaccgccg gcatcagagc ctggtagacc tcgcgcgtcg
     9001 cgttcgagcg gttgaaggtg atgaagtgga tccccggcgc gccttcgtcc aggagccggc
     9061 ggcacagctc gacgccgtgt tcgatgccca gctggtagac cgcgtcgggg tcgtctttga
     9121 ccttctcgaa gcgcgccgcg atcttcgccg ggaacggggc gcccgacagc tgctcggagc
     9181 gggcgatcgt gccgaacttg gtcaccggca tgatgccggg gatgatcggc gtgtcgcagc
     9241 ccgccgccgc gacccggtcg cggagccgga ggtagtcgtc ggcctcgaag aacatctggg
     9301 tgatcgcgta gtcggcgccg gcccggcatt tgcgtacgaa gaaatcgacg tcggactcga
     9361 tcgacggcga cctcgggtgc ttgtacggga acgccgccac ccccacgcag aactcacccg
     9421 actggcggat cagccggacc aggtcctcgg cgtagtggac accctcgggg tgcgcgaccc
     9481 actcgcccat cgggtcgccg ggcgggtcgc cccggacggc caggatgttg cgcacgcccg
     9541 cgtcggcgaa gcggccgatg aggtggcgca gttcgcgggt cgagtggtcg acggcggtga
     9601 agtgggcgac cggcgtcagc gtggtgctgt gcgcgatgcg ctcgacgatc tcgacggtac
     9661 ggtcgcgggt ggaacccccg gcgccgtagg tgaccgagac gaacgtcggc ttcagcgact
     9721 ccagttcccg gatcacccgc cagaggttcc gttccgcctc gggtgtcttc ggcggaccga
     9781 actcgaacga gaaagaccgt tcgccagccg cgaggagctc cttcacggtg gcgacacgat
     9841 cgggaaagcg tgaggggaga cccagagcca tgcggccaag gctactagtc ccgccggaaa
     9901 gacggcggga accgctttgc gagatgatcg aattcaacct cgccagcaac aaccaccccg
     9961 gtagatgaac gaatcgatca cctccagata ccctcaatac atgacaaatg ccaccgcgcc
    10021 tttggagttc atccgccccg aggtggaccg ggccctcaag cgcttcatcg accgccaccg
    10081 gatggcgttc gacgaccccg acctggccgt ggtgctgggc gcggtgcagg acttcctcac
    10141 gggcgggaaa cgcctgcggc ccgccttctg ctactggggc tggcgcgccg ccggaggcgc
    10201 cgacgacccg tcggtgatct ccgccgcggc ggccctggag ctgctccagg ccagcgcgct
    10261 cgtccacgac gacgtgatgg actccagcga tatgcggcgc ggcatgccct cggcgcaccg
    10321 gcgcttcgag aagctccacg tcgactccgg gtggcacggg tcggcggtgc agttcggcga
    10381 gggctcggcg atcctggtcg ggaacctgct cctcatctgg tcgggcgagc tctggcggac
    10441 ctccggcgtg gcctccgaag gcctggccgc cgcgcagccg gtcttcgacc acatgctgac
    10501 cgagctgatg aacggccagt acctcgacct gctggcccag gcgcacggcg agaactcgtt
    10561 cgagagcgcg cggcgggtgg cgctgttcaa gagcggcaaa tactcggtcg agcatccgtt
    10621 gcgcctcggc atgaccctgg cgacccagtc ccgcgaggga tggatcgacc aggtctgcgc
    10681 cggttatggg cagaacgtcg gcatcgcctt ccagctccgc gacgacgtcc tcggcgtctt
    10741 cggcgacccg gccgagaccg gcaagcccgc cggtgacgac ctgcgcgagg gcaagcgcac
    10801 gatgctcatc gcgcgcaccc tggagctcgc ctcacctgcc cagacccagt ctgttcgcgc
    10861 cctcgtcggc gaccccaagc tcgacgcgga aggcgtggaa gccctccggg gcgtcatcgt
    10921 ggacaccgga gccctcgcat cggtcgagga gctcatcacg acctacgtga ccgaggcact
    10981 ggcggtcctc gacgcggccc ccatcgaggc cgaggcccga gaggccctga aggccctggc
    11041 catcgcggcc acgacccgcc gcaactagac cccgaggcga cggctcagtt cctgggctgc
    11101 cgccttcggg tcttccgcct cggtgatggc gcgcacgacg accacgcgcg tcgcgccctg
    11161 ggccaggacc tcgtcgaagt tgcccaggtc gatgccgccg atggcgaacc acgggcgctc
    11221 cgccggcagg ccggaggcgt gcgccagcag gggaaggccc ggtgcgggcc ggcctggctt
    11281 ggtcggggtc ggccaggtcg ggccgcagca gtagtagtcg acacccggct cggccgacgc
    11341 ggcggacgcc tcgtcgaacg agtgggtgga gcggccgatc acgatctcct cgcccagcat
    11401 cgcgcgcgcg atggacaccg gcaggtcgtc ctgacccaga tgaagcacgt caggaccgaa
    11461 accggcggca cgggccgcgt acgcgacgtc cgcccggtcg ttgaccgaca ggagagctcc
    11521 atgccggtcg cagaccgcgc ggaagacctc gaggagggcg agctcctccc gggcctccag
    11581 acccttctca cggagctgga cgacgtccac tccgcccgag agcgccgcgt cgaggaattc
    11641 gaccaggtcg ccgcgctctc ggcggccgtc agtgcacagg tacaggcgtg agtcggcgag
    11701 tctgcgccgg gagggatcgg tcacccaccc aagatgccat gggtcctaga agccgagtgc
    11761 ctgggccctg cgcttcacct cggtgtggcg cccggccgtg aggaggtcga tcggggcgcc
    11821 gggcagcgac tcgtcgggag tgaaaagcca tctgatgcac tcgacttcgc tgaagcccgc
    11881 gtcggagagc acggtcagcg tccctggtag ccccttgatg acgtcgtctc cggcgatgaa
    11941 gaccgccggg atctgcggtt cgccgccgcc tctacgggcg ccgacgagtt tcctgtcctt
    12001 gatgagctgc ttcgccctgc cgatgctgag ctggagcttc ttcgctacgt ccgagagagg
    12061 gagccactcc cccacgagct ggtcggtgtc tcggtcgatc tgcgcaactg taagcgtcac
    12121 gaatccacca ttaccacacg gccgcctcca tgaaacaccc agtttacgcc acggtgcagt
    12181 ctcggagggt aacgcttggg tcggcgaggc ggccggcgtc gagcctttgc cgtccttcga
    12241 cgaggcgtcg gccttgcacc agatcgcgtg gtctgtcgac ggtcaggatc gcggtcaggc
    12301 ggtggtcggc ggtgagccag cacgccgccc atttggcgtc ggtctcgggg tcgccgcgca
    12361 ggaccaggtt ggcgccgtgg tggtgcccgg cgtactggac catgcggccg aactgctcgg
    12421 accagaagta gggcaccggg tcgtagatgg cgttctcgcc catcagggtc gcggcggcgg
    12481 tgtcgggggc gcccagggcg gtgtcccagt gttcgacgcg catgcggcgg ccgaagcggc
    12541 ggctgtacca gttggcgcag tcgcccacgg cgaccacgtt gggcgagaag ctgcgcaggt
    12601 gctcgtcgac cagcacgccg ttgtcgagtt cgacgtcgga gccgtcgagc caggcgacgt
    12661 tggggcgcac cccgacgccg gtgaccacca cgtcggccgg gatccggtcg ccgttcatca
    12721 gcgtcaggcc gtcggggtcg acggtgccca cggtggcgtc gagcagcagt tcgatgcccg
    12781 cctcggcgta ccaggggatc atgtatctgc cgatcggcag ggcggtggcc acgggggcct
    12841 cgcccgcctc gacgacggtg acctggcagc ccgctttggc cgccgcggtg gcgacctcgg
    12901 cgccgatcca gccggcgccg atgacggcga cgcgggcgcc ctcggtcagg ctcgcgcgaa
    12961 gggccagggc gtcgtcgatg gtgcgcagga cgtgctggtg gccctcgccg cgcaggcgga
    13021 tcgggctggc gccggtggcg acgaccaggc cgtcgaagga gagctctccg tcggttgtcg
    13081 acagaacgcc ctcacgcagg cccttggcgg cggtgccgag catgaggcgg acgttcagcg
    13141 cctccaggtc ggagtcgacg accgtggagt cggcgtcgcc gagcaggacc gccttcgaca
    13201 gaggtggacg gtcgtagggg cgatgaggtt cgtcgccgac cagggtgatg cgcccctgat
    13261 atccgtgggc ccttaacgcc tcgacactcc ggacgccggc caagccggcc cccaccacca
    13321 cgacgtgatc cacgagtaga ccctagattg ccgacgggcc cacccgccaa tggagattcg
    13381 gtaacgaatt gagtaagtag ctcgcacagc atggggattc cgtgttgtgc gaatcagatc
    13441 aattcgcatt actgtggaca aagacgcgcg ggagtccggc tgaccgggct gagaggggaa
    13501 ctccacaggt tctcgaccgc tatcgaacct gatccggatc atgccggcga agggagcgcg
    13561 atgaacgctt cggatgtatt cgtgatcggc ggcggcatcg ccgggctgtc gatcgcctgg
    13621 cgggccgcct cgcggggcct caccgtcacg ctcgccgacc ccgaccccgg ctcgcaggcg
    13681 acgcgtgcct ccgcgggcat gctggcgccc gtcagcgagg tcacctacac cgaggagccg
    13741 ctgctccggc tcgggctcgc ctcgctggag cgctggcccg agttcgcggc cgaactcgag
    13801 gagaagagcg gtgtccccgt cgatctgcgc tccgacggga cggtggaggt cgcctacgac
    13861 gccgacgacc tcgcccagct cgacgagctg gccgccttcg aggagaagct cgggctgcgc
    13921 gtggagcggc tcaccgggcg gcagtgccgc caggccgagc cgatgctgtc gcccaacgtg
    13981 cggggcggcc tgctggcccg cgacgacctg tgggtgaacc cgcgccgggt gacccaggcc
    14041 ctgcagaagg cgttccagaa cgcgggcggg aagatcgtca aggaacacgt caccacgctc
    14101 gacggcatcg aggccgacca gatcgtcgtc gccgccgggg cctggacgcc gagcctgctt
    14161 cccgggctgc ccgtccggcc ggtgaagggg cagatcctgc ggctgcgcgg cccgcgcggc
    14221 ttcctccaga agtgtgtacg gggaagggtg cgcggctccg acgtctatct ggtcccccgc
    14281 gacgacggcg agatcgtggt cggcgcgacg atggaggagc tcgggttcga cacccgggtg
    14341 accgccggcg gggtctacga actgctgcgg gacgcacgcg aactcgtccc ggggatcacc
    14401 gagctcgacc tggccgagac cttcgcgggg ctgcggcccg gcacccccga caacctgccc
    14461 tacgtcgggc ggcacggcga cgtgtgggtg gcggcgggcc atcaccgcgc gggcgttctg
    14521 ctcgcgccgc tgacggccga ggccgtcgtc gcctgtctcc acggcgaggc caacccgatg
    14581 cccgagtgcg acccctctcg cctcgacaca gaaagaatct gaatgcgcat cacgatcaac
    14641 ggtgacccgc acgacctcga cgacgggtcg acgctcacga aagccgtaca gacactgacg
    14701 aggcagccca cggggatcgc ggtggccgtc aacgacgagg tggtcagccg gggcgcgtgg
    14761 gacgcgaccc cactgaccga aggcgaccgg gtcgaggttc tgaccgcggt ccagggaggc
    14821 tgacgactga tggacgatcc tttgctgatc ggcggcgagg agttcgcctc gcggctcatc
    14881 atgggcaccg gcggcgcgcc gtcgctggag gtgctcgacc gggccctggt ggcctcgggc
    14941 accgagctga ccacggtcgc gatgcgccgg ctcgatccgg gcgcccgggg ttcggtgctc
    15001 gacgtgctgc gcgagcgcgg aatcaaggtg ctgccgaaca ccgccggttg tttcaccgca
    15061 ggtgaggcgg tgctgaccgc gcgactcgcc cgggaggcgc tcaataccaa ttgggtcaaa
    15121 ctcgaagtca tcgccgacga gcggaccctg ctgcccgatc cgatcgagac gttcgacgcg
    15181 gcggaacggc tggtcgccga cggtttcgtc gtgctgccct acatcggcga cgacccgatc
    15241 ctggcccggc ggctggagca ggcgggctgc gcggccgtca tgcccctcgg gtcgccgatc
    15301 gggtcggggc tgggcatccg aaacccgcac aacatcgagc tcatcgtgga atcggcgcag
    15361 gtgccggtga tcctggacgc cgggatcggc accgccagcg acgccgcgct ggccatggaa
    15421 ctgggctgct cggcggtgct gctggccacg gcggtgaccc gggcgcgcaa gcccgatctg
    15481 atggcggcgg cgatgcgcgg cgcggtcgag gcggggcgcc gggcgtttct ggcgggccga
    15541 attccccggc ggcgatatgc tgaggcgtcc tcaccgggtc gaccgttcca agacgggtaa
    15601 accttcctgt ttcggtctcg gtttgggatt cctgcactca gcatgtggca aatcacccgt
    15661 aaactcgagg ccgtggacac gacgctttct gatccgctcg tcgggcatgt gctcgatggt
    15721 cgctaccgcg tcgagtcccg gatcgcccgg ggcggcatgg cgtccgtcta tttggctctg
    15781 gacgtccggc tcgaccgcat ggtcgcgatc aaggtgatgc accgatcgct ggcagaggac
    15841 cccgagttcg tccggcggtt catcggtgag gccaagtccg tcgcctcgct gtcacatccc
    15901 aacatcgtgc acgtcttcga ccagggcacc gacggtgacc acgtctacct gtcgatggag
    15961 tacttccccg gcaagacgct gcgggcggtg ctcgacgagc gggggccgct ggcgccgcgc
    16021 gaggcgctgg agatcatgat cccggtgctg gcggcgctcg gcagcgccca ccaggccggg
    16081 ctgatccacc gtgacgtgaa gcccgagaac gtgctgatga ccgaagacgg ccgggtcaag
    16141 gtcgtcgact tcgggctcgt gcgggccatc gagggcggca accagacgcg cagcggcgtg
    16201 atgatcggca cggtcggcta catggccccc gagcaggtca cctccggcca ggccgacgtc
    16261 cgcagcgacg tctactccgc cgggatcatg ctgttcgagc tgctcaccgg gcgtcagccg
    16321 ttcggcggcg agagcccggt gtcggtcgcc taccggcacg tccacgagtc gatcccggcg
    16381 ccgtcgtcct tctcctacga catcccgccg tcgctcgacg cgctggtcgc gaaggcgacg
    16441 gccaaggagc cggccgaccg caaccacgac gcgaacgcga tgctggtggc ggcggtcgaa
    16501 gtacaccgca ccctgcccca gacctcgacg gggcggcact cggtgccgcc ccggcagcag
    16561 tcggcggagc aggccttctt ctccggctcc cacacgatga tccagccggc catcgaggtc
    16621 ccgccgaccc ggccgccgag ggcggcggtg cggcgcgggt tccgggtgaa ctggttcatc
    16681 gtcgcgctgg ccgtgctgat ggtgggcggc atcgcgttca gcgggtggta tttcacgctg
    16741 tcgcgcaccg cgatcgtgcc cgacctggtc aagcgcaaca tcgaggcggc ccgtcagctc
    16801 gccgagagca acggcttcac catcaagatc ggtgagggcc gcttcgacgc caaggtgccc
    16861 aaggacatgg tcctggagac cagtccgctc aagggcgtcg aggccgagcg cggctcggtc
    16921 atcacgatca tcgcctcgcg cggccccgag atggtcggcg tgccgaagac cgagggcatg
    16981 accgaggccg acgcgcgggt cgcgatgtcg gacgccggtc tgaacgtgtc ccggatccgc
    17041 cgcaccccga gcgacaagat cgggcgcggc ctggtgatca agaccgaccc cgtcgtcggc
    17101 aagaaggtcg agaagggctc caacgtcatc ctggcgatca gcatgggcct gctgatgccc
    17161 agcgtggtcg acctgccgcg cgaccaggcc gaggcgctga tgcgggagaa cggcttcgac
    17221 ccgagctgca tcaacgaggt tgtcgacgag aagccgggca acaccgtcat cgcccaggag
    17281 ccggccgccg gcgccgaggt cgacaagggc gcccgggtct gcctgaccgt ctcacgcggc
    17341 cccgacaccg gctggcagtg gccctgggag caagatccct cggtcgccgc gcccgacttc
    17401 gtgaacgtcc ccgacgtgcg gttcaagaac gtcgaagagg ccaagcgcga gttacaggcg
    17461 gccgggttca aggtccaggt gcacaagctg ttctcccgcg gccgccccgg cggcgacggg
    17521 cccggtcagc gggtgcgcgg ccagaacccg ctcggccagg tgcccgcagg cagcacgatc
    17581 aacctgtggt tctaggcgag aacccgcgtc aagaaagcag gtcacccagc agccgaagcc
    17641 gggccaggcc accgtcgggg tagatgtcac atttgacgtg ggtcaccggg cggtcgctgt
    17701 cgagccggaa ccggtggggc gcgtcgggct ggaggcgggt cttgccgagc aggctgaacc
    17761 agtcgccgtc accgtcgcgg cccgacagcg acacccagcc gggcgcgttg aagaccaggt
    17821 gggtggtgtc gatctcggcg accgtgacgg tgccgcgccc ggcgaggcgc accaccagcc
    17881 agtcgttgcc gtcgtcgcgg cggcgcgcgg tctcccagcc ttcggcctgg tggcgggcca
    17941 ggcccggggc gatgacgttg ttgggcgagc tgtagaactg gttggagcag tcgatcacca
    18001 gggcgccgtt ggcgagggcg gccaggtcga cggtgaggcc gtgcaggaac gccgggtcgg
    18061 gcaccacctc gccgtgcacc cggagccggg ccactccccc gtcgggatag atgttgagcc
    18121 gcacgtgcgt gtagcggttc gggtcgtcga cggcgaactc gtgttcgcgg tcgccgccga
    18181 gagggctcct gggcaggatc tcggtccagc cggtcagctc ctcgtgggcc agcggctcgt
    18241 cggccgtgca ggcctcgacc gaggcgtagg gcgggtagtt gcccttgaac caggccgtgt
    18301 cgatcaccag cccgtggatg acgccgggca ggccgagccg gacgatcgcc cagtcgtgcc
    18361 cggtggtgcg ccgccgccgg gtctcccagc cgtcgtagat ctggcccttg gcgccgaagt
    18421 cgtgggtgtg gaacagggcg gggtgcgggc ggatgagcgc ctggcggtcg gcgaacgcct
    18481 cgtcgttggc ggcgatcacg gagccgccca ggccgcgcac ggccaggtcg ggcagatggc
    18541 ggaaggtcat cgggcgcctc tcgtcagaaa ccggccgtgg ccgggagcgt caccgcgcag
    18601 ccaggtctgc tggacgacgc ccttcagcga cctcccctgg taggcggtga ccgggttctt
    18661 gtgggcgagg tcgcccgcct cgacgacgaa gcccgcctcg gggtcgaagg ccaccaggtc
    18721 ggcgtcggcg cccacctcga tccggccctt ggaggagagc ccggcgaagt cggccgggcc
    18781 ccgggccatc cagcggacga cgtcctccag cgagaagccc cgtgcggacg cctcggtcca
    18841 gatggcgggc agacccagct ggagggagga gatcccgccc caggccgtga cgaaatccgg
    18901 ggagtccagg cccttcatgt cggccgggca gggcgagtgg tcggagacga tccccatcag
    18961 ggtcccgtcg gccaggcccg cccacagggc gtcgcggttg gccgcctcgc ggatcggcgg
    19021 gcagcacttg aacgcggtgc cggtgacctc ctccgcgctg agggtcaggt agtggggaca
    19081 ggtctcggcg gtgatccgca ctccctgcgc ctgggcctcg cgcagcaccg cgatcgcgtc
    19141 tccggcggag acgtgcacga tgtgcgcccg cgcgccggtc tcccgggcca ccgcgatcac
    19201 cgtctcgatg gccctgacct cggcctcctg ggtgcgcgag tcgaggaact cggagtagga
    19261 ggggccggtg ggctcggtca gcgtccaggg gtcctcggcg tgcgcgatga gcaggccgtc
    19321 gaagcgggcc agttcctgga gcgcgcgggt gaggccgttg gcgtcgaggg cggggaactc
    19381 gtcgacgccc gacggggaca ggaagcactt cacgccgaac accccggcgt cccacagcgg
    19441 gcgcaggtcg ccgaggttgc cggggatcgc gccgccccag aagccgacgt cgacggcgat
    19501 ctggccgtac gcggccttct tcttgatctc caggttgggc acggtcgtgg tcggcggcag
    19561 cgagttgagc ggcatgtcga cgaccgtcgt cacgcccccg gccgccgctg cccgggtggc
    19621 ggtggcgaag ccctcccagt gggtgcggcc gggttcgttg atgtggacgt gcgtgtcgac
    19681 caggccgggc agcagcgcga cgtcaccgag gtccaggcct tcgtgggtgg tgtacggcac
    19741 cagccccgcg atccgcccgt cgacgacgtc caccccgagc ggcagtaccc cttcgggggt
    19801 gaccacccgg cgtgaccgca ccagaaccgt catacgcgct ccttcaccac actcgccacg
    19861 agtcgctcaa gaagtggccc cgcctcggcc atgcaccgcg cggggtcggg ctcgatgtcc
    19921 gtcagggcgt acgccgcctc gatcccggcc ttgcgcaggt cgtcgtctga gacctcgcgc
    19981 cgcccgcaga ccgcgatgac cggcacgccg tgccgcatgg cggcgttggc gaccccgacc
    20041 ggggccttgc cgcgcagcga ctgctcgtcg agcgagccct cgcccgtgat cacgaggcgc
    20101 gcgccctcga tgtgggtctc gaagtcgagc aggccgagca ggtaggcgat gccgggccgg
    20161 atcgacgcct tcaggaaggc gagcgcggcg aagccgacgc ccccggccgc cccggcgccg
    20221 ggctgtccgg ccacgcccat cgcgcggacg atcccgtcgt gctcgatcga cccggtcagg
    20281 ccgtgggtgt ggacggcgac ggcggccagc ctcgacagcc ccgcttcgag cagcttcacc
    20341 tggtcgggcg aggcgccctt ctgcgggccg tagacagtgg cggcgccgtg cgggccgagc
    20401 agggggttgt cgacgtcgga ggcgaccacg tagtcggcgg atccggcgtc gaagccggac
    20461 aggtcgatct tcgccaggtc tttcagggag cccccgccca gcgggagttc ggccccctcg
    20521 tcgtcgagga agcgggcgcc cagcgcgcgg gccaggccgg tgccgccgtc ggtgcaggcg
    20581 ctgccgccca ggcccagcac gatccgggtg gcgccctgcg cgagggcgtg ggcgatcagt
    20641 tctccggtgc cgtagctgga ggcggtcagg ggttccagtc caccgggcag gcggcgcagc
    20701 ccggacgcct cggccatctc gacgacggcg gtgtcgtccc tgacggcgta cgaggcccgg
    20761 atcggctgcc ccgtcggccc ggtcacctcg acctcgacgc gggtgaaacc gcaggccgcg
    20821 acggcgtcta cggtcccgtc gccgccgtcg gccacgggga ggagcactac cgggacatcg
    20881 ccgaggccgg cggcgacgtg gtgggcgacc tcgggggcgg tcagcgagcc cttgaacttg
    20941 tccggggcga tgacgatgtg atccctcatg ccgtcatcat gaccgaagca gccgggcgtg
    21001 cgcccgcgcc cccgccgctc cggcggcgtc gccggagacg gtccgcaggt cgccgttctc
    21061 gaccacgg
//
