LOCUS       NZ_KQ948868            10216 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces bungoensis strain DSM 41781 PRJNA299233_s018, whole
            genome shotgun sequence.
ACCESSION   NZ_KQ948868
VERSION     NZ_KQ948868.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces bungoensis
  ORGANISM  Streptomyces bungoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 196248)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces bungoensis DSM 41781, type
            strain for the species Streptomyces bungoensis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 196248)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.6x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001514215.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:15:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,539
            CDSs (total)                      :: 7,454
            Genes (coding)                    :: 7,226
            CDSs (with protein)               :: 7,226
            Genes (RNA)                       :: 85
            rRNAs                             :: 1, 1 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            tRNAs                             :: 80
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 237
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 237
            Pseudo Genes (frameshifted)       :: 67 of 237
            Pseudo Genes (incomplete)         :: 196 of 237
            Pseudo Genes (internal stop)      :: 10 of 237
            Pseudo Genes (multiple problems)  :: 43 of 237
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:26:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 32203
            Orig. end                         :: 42419
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ948868.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(280..296)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            complement(1867..4092)
                     /locus_tag="AQJ66_RS28290"
                     /old_locus_tag="AQJ66_28285"
     CDS             complement(1867..4092)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040519.1"
                     /locus_tag="AQJ66_RS28290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_28285"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_061927737.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.6e-38, bitscore:
                     122.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPTAQETRGRRRAAPARRPVPKSRTGTVRTPTVLQMEAVECGAA
                     SLAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARGYGLTAKGMQMDLAALAGVR
                     APAILFWEFNHYVVYDGMGRRFGRRGVYVNDPAKGRRFVPMEEFDGGFTGVVLVLEPGD
                     GFTRGGRKPGVLGALPARLRGTAGTLPAAVLASLLLVAVGAALPALSRTYIDTFLIGGQ
                     TSLLGVLFAAMAGCVLLTLVLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFAQR
                     SPADLVQRLQSNDQVAETLARDLAAAGVDAVVVVLYAVLLYTYDPQLTFLGIGVALLNV
                     VAMRLVVRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHAATL
                     EEQQRLGVPSAWLGVVAPTLATVNSALILWIGGLRAVEGHITVGLLVAFQALVTRFTAP
                     LTRLNGVAGRIQDFAADVARLKDVENFRTDPLYARPGTGDSTRRLHGHVELENVTFGYS
                     PLDQPLLTGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYTPWDGVIRIDGRRLEDVP
                     RGALASSVSFVDQDVFLFEGSVRDNVALWDPSIPDEAVVEALKDAALYDVVTRRPGGIH
                     SGVEQDGRNFSGGQRQRLEIARALVRRPSVLVLDEVTSALDAETEQVVMDNLRRRGCAC
                     VVIAHRLSTVRDSDEIVVLQHGTVVERGRHEELVARGGAYAALVRER"
     gene            complement(4089..4895)
                     /locus_tag="AQJ66_RS28295"
                     /old_locus_tag="AQJ66_28290"
     CDS             complement(4089..4895)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="AQJ66_RS28295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_28290"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_061927739.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRLARPQGWLALGVTVLVMAAASVW
                     AVTGSVASTVAAPAVLTHGQGSYVLQSPVAGQVTAVLARQGQRLPAAAPVLKVRTAQGT
                     SVVRTVAAGRVTALAATLGQIVQTGTDVAAVEKVAHASDPLYATVYVPAENAAAIPAHA
                     SVDLTVSSVPAQKYGVLRGRVKSVDRTAQSAQSVAAFLGDSQLGEQLTRTGRPVAVLVE
                     LDRSARTRSGYRWSTAGGPPFRLDSMTLASASVRLAGRRPVDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="AQJ66_RS28300"
                     /old_locus_tag="AQJ66_28295"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="AQJ66_RS28300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_28295"
                     /product="hypothetical protein"
                     /protein_id="WP_061927741.1"
                     /sec_met_domain="strepbact (E-value: 1.1e-35, bitscore:
                     115.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETAEISDAELDAVSGGLSVNALSTVTGAVNGVAPVSGL
                     VDTAIGTVEGVTGLNTQPVTNLVAGL"
     misc_feature    complement(5187..5202)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    complement(5749..5764)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.27"
                     /tool="antismash"
     misc_feature    5759..5770
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            5864..7246
                     /locus_tag="AQJ66_RS28305"
                     /old_locus_tag="AQJ66_28300"
     CDS             5864..7246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430713.1"
                     /locus_tag="AQJ66_RS28305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_28300"
                     /product="S1 family peptidase"
                     /protein_id="WP_167359192.1"
                     /transl_table=11
                     /translation="MSHKRMPKRKAAIAVGGVAALGAAALLLPNANASQDKDQAAGAAG
                     TVKTLKAADASNLSAHLQKALGDALAGSYYDGAKQQLVVNVVSGDKNVIVQAKKAGAAV
                     RRVDNTTASLKAAARTLKTRATIPGTAWAIDPRTNKVAVTADSTVTGAKWDKLQSTVRS
                     LGSGMATLKKSAGAFKTLVSGGDAIFSQVQGGGVRCSLGFNVTASDGTPAFLTAGHCGV
                     AAKDWSDSQNGQPIATVDQATFPGNDFSLVKYNDATTQAPSEVNAGNGQTVQITQAADA
                     TVGETVFRMGSTTGLHNGQVTGLDATVNFQSETNPGGVDTVNGLIQTNVCAEAGDSGGS
                     LFTQDGGAVGLTSGGSGDCTSGGETFFQPVTAALQATGATLGNGGNGGNGAGGQAGAGD
                     QSGTAAPSASPGDNGAGNGAGDQSGTADPSATAGDQNGAGTGTGTGDQSGTGDGSSLNG
                     SN"
     gene            complement(7427..9553)
                     /locus_tag="AQJ66_RS28310"
                     /old_locus_tag="AQJ66_28305"
     CDS             complement(7427..9553)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569992.1"
                     /locus_tag="AQJ66_RS28310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_28305"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_061927984.1"
                     /transl_table=11
                     /translation="MSDGPEAGRAPAPATARSRRPLLSPALAALLEELHAHSGAVYLLH
                     PEEPVLEMAVMAGMPRAFAAPWERVGLSAPIPVADAVRERRLVWVSGEEEMARRYPRIA
                     VVLPYPFALAALPLATADTVYGAVFVTWPGGHPPELTDRERERLRAGCDRLARAAEENR
                     PLGREADLLAAPVSGVAGTLGSVEAARMVARLPYGLVSLDLHGRIAFANPAAAELLGRP
                     AGELLGTLPWVSVPWLNDPMYEDRYRAALISQHVTSFVALRPPGQWLSFRLYPSTTGLS
                     LRISRARPVAEMAGPARKPGSGPSRLVTISQVLSLAGALTEAVGVQDVVQLVADEVAPA
                     VGSQALVVLGSQGGRLHVLGHRGYPDPRVVERFDGLPLTERTPGTHVLVSGVPAFFDSR
                     EQLWRLYPDRHWDTPFAAWAYLPLIASGRPVGTCVLAYAEPHVFPADERAVLTSLGGLI
                     AQALERAQLYDAKHGLAQGLQESLLPHSLAPLPGIEAAARYLPATQGMEIGGDFYDLVP
                     TGPLAAAVIGDVQGHNVTAAALMGQIRTGVRAYTTVGQEPHEVMRSTNRLLADLGAELF
                     ASCLYLRLDPVRGRAVMARAGHPPPLLRRPDGRVRVLDLAGGPLLGIDASATYPTTEVS
                     LAPGSVLALYTDGLVESPGVDIEDSLVDLGALLAEAGDQPLEHLADALVRHSAAARRRM
                     DDVAVLLLRAHGAD"
     misc_feature    10174..10189
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.14"
                     /tool="antismash"
ORIGIN
        1 accgcgccca gcaccgaggt caggttcctg acccggccca cctgctgctg gagctcccgg
       61 ctgcgcgcga actgccgggc ccaggccgcg tacgcgtagt tctccgccgc cgccacccgc
      121 agcttcggca ggccgcgcag cgtctggaac gcctggttgt tcagcttgtt gccgagcacc
      181 accaggcgcc gctgcccccg cacctgccac agcccgagcc ccaggaacac ccccgcgatc
      241 acgacgagca tgccgaccgc ggccagcgcc atcggcacgc tgtaccagaa caacaggccg
      301 aggttcatcg cgccgaccgt gaccgactgc gcgaccaccg ggccgacgcc cgccagcagc
      361 cgccggatcg cgctgatgcc catcgccgcg ctggcgagct ccccggtgga gcgctgggtg
      421 aagaaccggg tcgggagcct gagcagccgg tcccagacgg ccggctggag cgcggcctcg
      481 atccggccct ccaggcgcag gatggtcagg ttctccagca gcgtgaacgc ggccgacacc
      541 acgccggcga ccatcaccgc caggcacacc tggacgatca ggccctcctc ggcccgcggc
      601 acgtactcgc caagcacctt gccggtcgcg atcggcacca gcgcgccgat caccaccgtc
      661 accagcccgg ccagcaacag gttggccagg tcgccgcggg tgccgcgcag gctgaaccgg
      721 agcagcccga acggcccgag ccgccggtcg ggcagcggcc ggtagaacat caccgcacgc
      781 ggctcgaact cctccgcgtt cgccttctcg atcggcgtct cgcgcccggt ccccgggtgc
      841 acggccacat agccgccgcg ccgccacagc agcgccaccg gcgccccgga cagcgcccgg
      901 cgcccgacca gcgggcccac gttctcccgc caccagcggc cctccagccg caccgcccgg
      961 gtacgcaccc gcgaggccag cgccacccgc tcgaccgggt cgaggcgctc gctctcggcg
     1021 ccgctctgcg cgggctccgc cagcctgatc ccggccgcct cggcgaccag ccggcaggcc
     1081 gcgtacccgg cgtcggcgtc ggcggccgtc gtacggcgcg ccgagcgcct gccgatcgat
     1141 gccagcaggg tccggtcggc ctgggcgcgc accgcctcac cggccttgat gccggccgcg
     1201 gcgcgcgtct cgtgggtgcg ctccagctgc tcgatccagc ggtccagcgc ggtcagcagc
     1261 cggtactgct ggtcgaccac ggactgccac agcgccgggt ccatcagcag gtcggcggcg
     1321 gcgtccgcgc cgtacagcga gccgtactgc acgctgcccg gcggcacctg catccagaac
     1381 acgtcgtcgt cggcgggcgc ggcggcccgc tcctcggcca tcggcgcctg gaagaggacg
     1441 gacagcccgc ggccgacccc cagggcgacg gcgtactcca ggggactggt cgccggcggc
     1501 acgtactggg ggttgccgta cgcgtcgtac gaccaggtct cggtgggggc cggctggtac
     1561 agctcgcgca ggcccacgcg gtgcaccacg cagtcgcgca ccgggcgcgc caccagcgtg
     1621 tgctggggcc cggcgaccgg gccgagcagc agcccgcccg cctccagccg gccgaggtgg
     1681 tgccagtggc cctgctgggc cgcgtccacc gcgaacaggt ccagggctcc ggccgcgacc
     1741 agccacagca cctgcggacc ctccaggtcc aggcggccgg agcccgcgca gtcgacccgc
     1801 gtgcccagcg agccgagcgc cccgagcacc aggtcgccct cctgcccgtc ctgaacggcc
     1861 gtcatctcat cgctccctga ccagcgcggc gtacgcgccg ccgcgcgcca ccagttcctc
     1921 gtggcggccg cgttcgacga ccgtgccgtg ctggagcacg acgatctcgt cgctgtcgcg
     1981 gaccgtgctc agccggtggg cgatcaccac gcaggcgcag ccgcgccggc gcaggttgtc
     2041 catcacgacc tgctcggtct ccgcgtccag cgcgctggtc acctcgtcca ggacgaggac
     2101 gctcggcctg cgcaccagcg cccgggcgat ctccagccgc tggcgctgac cgccggagaa
     2161 gttgcggccg tcctgctcga ccccgctgtg gatgccgccg ggccggcgcg tcaccacgtc
     2221 gtacagggcc gcgtccttca gcgcctccac cacggcctcg tccgggatcg acgggtccca
     2281 cagggccacg ttgtcgcgga ccgagccctc gaagaggaac acgtcctggt ccacgaagga
     2341 caccgaggag gcgagcgcgc cgcgcggcac gtcctccagg cggcgcccgt cgatgcggat
     2401 caccccgtcc cacggcgtgt acaggcccga gatcagccgg gacaccgtcg acttgccgct
     2461 gcccgagccg ccgaccagcg cgacctgctg cccggggccc accgtcaggt cgaagccggt
     2521 cagcagcggc tggtccagcg ggctgtaccc gaaggtgacg ttctccagct cgacgtgccc
     2581 gtgcagccgg cgcgtggagt caccggtgcc ggggcgggcg tagagcgggt cggtccggaa
     2641 gttctccacg tccttcagcc gggccacgtc ggccgcgaag tcctggatgc ggcccgccac
     2701 gccgttgagc cgggtcagcg gggcggtgaa gcgggtgacc agcgcctgga aggcgaccag
     2761 cagaccgacc gtgatgtgcc cctcgaccgc ccgcaggccg ccgatccaca ggatcagcgc
     2821 gctgttcacc gtggcgaggg tcggcgcgac caccccgagc caggcgctcg gcacgccgag
     2881 ccgctgctgc tcctccaggg tggcggcgtg ctgcccggcc cacttgcgga agtagccgtc
     2941 ctccccgccg gtcgccttca tcgtctcgat cagctgcagg ccggtgtacg ccgtgttggt
     3001 gagccgcgcg gtgtccgcgc gcagcttggc cgtgcgggtc gcgcgcagcc gcaccaccag
     3061 ccgcatggcg acgacgttga gcagggccac gccgatgccg aggaacgtca gctgcgggtc
     3121 gtaggtgtag agcaggacgg cgtacagcac gaccacgacc gcgtccacgc cggccgccgc
     3181 caggtcccgg gccagggtct cggcgacctg gtcgttggac tgcagccgct gcaccaggtc
     3241 ggcgggggag cgctgggcga agaaggtcac cggcagacgc agcagatggc gcaggaagcg
     3301 ggcgctggag agggtggagg agatgatccg gccgtgcagc aggttggcct gctgcagcca
     3361 ggtcagcacc agggtcagca ggacgcagcc ggccatggcg gcgaacagca cgccgagcag
     3421 cgaggtctgg cccccgatga ggaaggtgtc gatgtaggtg cggctgagcg cgggcagggc
     3481 cgcgccgacc gccaccagca gcaggctggc caggacggcg gcgggcaggg tgcccgcggt
     3541 gccgcgcagc cgggccggca gcgcgccgag cacgcccggt ttccggccgc cccgggtgaa
     3601 gccgtcgccg ggctccagga ccagcacgac gccggtgaag ccgccgtcga actcctccat
     3661 ggggacgaac cggcggccct tggccgggtc gttgacgtac acgccgcggc ggccgaagcg
     3721 gcggcccatg ccgtcgtaga cgacgtagtg gttgaactcc cagaagagga tggcgggtgc
     3781 ccgcaccccg gcgagggccg cgaggtccat ctgcatgccc ttggcggtca ggccgtaacc
     3841 gcgggccgcc ttcagcaggt tgctggcgcg ggagccgtcg cgggagacgc cgcacgcgat
     3901 gcgcagctcc tccagcggga cgtgccggcc gtagtggccg aggaccatcg cgagggaggc
     3961 ggcgccgcac tcgacggcct ccatctggag cacggtgggc gtacggaccg tgccggtacg
     4021 ggacttgggg accgggcgcc gggcgggggc ggcgcgccgg cggccgcggg tctcctgggc
     4081 ggtggggctc acggcagcag ccaatcgacg ggacgccggc cggccagccg gaccgaggcg
     4141 gaggcgaggg tcatggagtc cagccggaac ggcggaccgc ccgcggtgga ccagcggtag
     4201 ccgctgcgcg tccgcgccga ccggtcgagc tcgaccagga cggccaccgg gcggcccgtg
     4261 cgggtgagct gctcgccgag ctggctgtcg ccgaggaacg cggcgaccga ctgggcggac
     4321 tgggcggtgc ggtccaccga cttcacccgg ccgcgcagca cgccgtactt ctgggcgggt
     4381 acggaggaca cggtcaggtc gacggaggcg tgcgcgggga tggcggcggc gttctcggcg
     4441 ggcacgtaca ccgtcgcgta cagcgggtcg gaggcgtggg cgaccttctc caccgcggcg
     4501 acgtcggtac cggtctgcac gatctggccg agggtggcgg cgagcgcggt gacccggccg
     4561 gcggcgaccg tgcgcaccac cgaagtgccc tgggcggtgc gcaccttgag gacgggcgcg
     4621 gcggccggca gccgctggcc ctgccgggcg agcacggccg tgacctgccc ggccacgggg
     4681 ctctgcagca cgtaactgcc ctgcccgtgg gtgaggacgg cgggcgcggc gaccgtggag
     4741 gcgaccgagc cggtcaccgc ccagacggag gcggccgcca tgacgaggac ggtgacgccc
     4801 agcgcgagcc agccctgggg gcgggccagc cgcaccggga ggtcgagctc ctccggcgac
     4861 tggagcttgg cgagggcctg ttggcggaac tgcacggaac ttcccccacc tgcctgtggg
     4921 tcgggcgcgt cgggttcagg gcatcgatga gtcccggaac cgggggaacg gctccgggac
     4981 tcaacggtga ggcggtgcga tcagagaccg gcgaccaggt tggtgaccgg ctgggtgttc
     5041 agaccggtga caccctcgac cgtgccgatg gccgtgtcga ccaggccgga aaccggggcg
     5101 acgccgttga cggcaccggt cacggtggag agggcgttca cggaaagacc gccggagacg
     5161 gcgtccagct cggcgtccga gatctcggcg gtctcgacct ggggggtgga gttcatggtg
     5221 gaacttccct tcatatggat attcacaagg gggagagcgg ccccctctgg gggacagacg
     5281 gacggccgcg accgcgggcg ccgggcaccc gtctccggga ccccggggcg agccctgcgg
     5341 tgcgatggat caaagcacgc acgcgggccg ggcttccaat caaccagacc cctcaccagg
     5401 caacttggtc gaagtgccga cgcaaccgtg caggtgcgcg cacggcatgt cggcgactcc
     5461 ttcacatggc gcacggcatc ggcgcatccg cgcccttgcc cgtcccgggc gaattccggc
     5521 actcggcgcc aaaggcgtgc cggggggcgc gcggatgtgc agatccgcgg gcggcggtgc
     5581 cctgcttggg cattcgatgt gcagattccc tgaagcaggc attccggtac gtgttcggaa
     5641 ccgaccgcta ccgagcggtc gctgaacgtg tcggtcgcgc ggcgatccgc gggcgtgctc
     5701 tggcgcgaag gtgccgcacg gtggccgatt ccctgtcgcg gggcggaagt tgacaagcgg
     5761 aattgaacgc accgctcgac ccgcccgtac ctacagccat ccaggcgccc cccgaacgac
     5821 tgcccgacaa cggcagaccc ccgtacccag gaggtcgaga agtttgagtc acaagcgaat
     5881 gcccaagcgc aaggccgcga tagcggtggg cggtgtcgcg gcgctcggag cggcggctct
     5941 cctgctgccc aacgccaacg cgtcccagga caaggaccag gccgcgggcg cggccggcac
     6001 cgtgaagacg ctgaaggcgg cggacgcctc gaacctgtcc gcgcacttgc agaaggccct
     6061 cggtgacgcc ctcgccgggt cctactacga cggtgcgaag cagcaactgg tcgtcaacgt
     6121 cgtcagcggc gacaagaacg tgatcgtgca ggcgaagaag gcgggcgccg ccgtgcgtcg
     6181 ggtggacaac accaccgcct cgctcaaggc cgccgcgagg acgctgaaga ccagggcgac
     6241 catcccgggc accgcctggg ccatcgaccc gcgcaccaac aaggtcgccg tcaccgccga
     6301 ctccaccgtg accggcgcca agtgggacaa gctccagtcg accgtgcgga gcctcggctc
     6361 gggcatggcg accctgaaga agtccgccgg cgccttcaag accctcgtct ccggcggcga
     6421 cgccatcttc tcccaggtgc agggcggcgg cgtgcgctgc tccctcggct tcaacgtcac
     6481 cgcctccgac ggcacccccg ccttcctgac ggccggtcac tgcggggtcg ccgccaagga
     6541 ctggtccgac tcccagaacg ggcagcccat cgccacggtc gaccaggcca ccttcccggg
     6601 caacgacttc tccctcgtga agtacaacga cgccaccacg caggcgccca gcgaggtcaa
     6661 cgccggcaac ggccagaccg tgcagatcac ccaggccgcg gacgcgaccg tcggcgagac
     6721 cgtcttccgc atgggctcca ccaccgggct gcacaacggc caggtgaccg gcctcgacgc
     6781 caccgtcaac ttccagagcg agacgaaccc cggcggcgtc gacacggtca acggcctcat
     6841 ccagaccaac gtctgcgccg aggccggcga cagcggcggc tccctgttca cccaggacgg
     6901 cggcgcggtc ggcctcacct ccggcggcag cggcgactgc accagcggcg gcgagacctt
     6961 cttccagccg gtcaccgcgg ccctgcaggc caccggcgcc accctcggca acggcggcaa
     7021 cggcggcaac ggggccggcg gccaggcggg tgccggcgac cagagcggca ccgcggcccc
     7081 ctcggcctcg cccggcgaca acggcgccgg gaacggcgcg ggcgaccagt ccggcaccgc
     7141 cgacccgtcc gccacggccg gcgaccagaa cggtgccggg accggcacgg gtacgggcga
     7201 ccagtccggc acgggtgacg gctcgtccct caacggctcc aactgacagg tccggcaccg
     7261 gctccgggct ccctggaccc ccgggcctga gccgctccga gactccctga ccggcccacc
     7321 gcggttccgg ccggcaggga cggtccggtc ctccggcggg agggccggac cacacccgtt
     7381 cccggtcgtg gcccgggatc ctcacgcacc ggccccggcc cgaggctcag tcggccccat
     7441 gggcccgcag cagcagtacg gccacgtcgt ccattcgtcg ccgggccgcc gcgctgtgcc
     7501 ggacgagtgc gtcggcgagg tgctccagcg gctggtcgcc ggcctccgcc agcagggcgc
     7561 cgaggtcgac gagggagtcc tcgatgtcca cgccggggga ctccaccagg ccgtccgtgt
     7621 acagcgcgag cacggaaccg ggggccaggg acacctcggt cgtcgggtac gtggccgacg
     7681 cgtcgatccc cagcagcggc ccgccggcca ggtccagcac ccgcacccgc ccgtccgggc
     7741 gccggagcag gggcggcgga tgcccggcgc gcgccatcac ggcccgcccc cgcaccgggt
     7801 cgagccgcag gtacaggcag ctcgcgaaca gctccgcgcc gaggtcggcg agcagccggt
     7861 tggtgctgcg catgacctcg tggggctcct ggcccaccgt cgtgtacgcc cgcactcccg
     7921 tgcggatctg ccccatcagc gccgccgccg tcacgttgtg cccctgcacg tccccgatca
     7981 ccgccgccgc cagcggcccg gtggggacca ggtcgtagaa gtcgccgccg atctccatcc
     8041 cctgcgtcgc cggcaggtag cgggcggccg cctcgatacc gggcagcggc gccagcgagt
     8101 gcggcaggag cgactcctgc agtccctggg ccagcccgtg cttggcgtcg tacagctggg
     8161 cccgttccag ggcctgcgcg atcagcccgc cgaggctggt gagcaccgcc cgctcgtcgg
     8221 cggggaagac gtgcggttcg gcgtaggcca gcacacacgt gcccaccggc cgccccgacg
     8281 cgatcagcgg cagatacgcc caggccgcga acggcgtgtc ccagtgccgg tcgggataca
     8341 gccgccacag ctgctcccgc gagtcgaaga acgccggcac gccgctgacc aggacgtgcg
     8401 tgcccggggt gcgctcggtc agcggcagcc cgtcgaaccg ctccacgacc cgggggtccg
     8461 ggtagccgcg gtgccccagc acgtgcagcc ggccgccctg ggaaccgagg acgaccagcg
     8521 cctgactgcc gaccgccggg gcgacctcgt cggcgacgag ctgcaccacg tcctggacgc
     8581 ccaccgcctc cgtcagtgcc ccggccaggc tcagcacctg cgagatggtc accagccgcg
     8641 agggcccgga gcccggcttt cgcgccggac ccgccatctc cgccaccggc cgggcccggc
     8701 tgatgcgcag gctcagtccc gtcgtgctcg gatacagacg gaacgacagc cactggcccg
     8761 gcgggcgcag cgccacgaac gacgtcacgt gctggctgat cagcgcggcc cggtagcggt
     8821 cctcgtacat cgggtcgttc agccacggca ccgacaccca gggcagggtg cccagcagct
     8881 caccggcggg ccggccgagc agttcggcgg ccgccgggtt ggcgaaggcg atccggccgt
     8941 gcaggtccag cgagaccagg ccgtagggca ggcgggccac catccgcgcc gcctccaccg
     9001 accccagcgt gcccgccacc ccggagaccg gtgccgccag caggtcggcc tcgcggccca
     9061 gcggccggtt ctcctcggcg gcccgcgcca gccggtcgca gccggccctc agccgttcgc
     9121 gctcccggtc ggtcagctcc ggcggatgcc cgcccggcca ggtcacgaac acggcgccgt
     9181 acacggtgtc cgccgtcgcc agcggcagcg cggccagcgc gaacgggtac ggcagcacca
     9241 ccgcgatccg cggatagcgg cgcgccatct cctcctcgcc gctcacccac accagacgcc
     9301 gctcccggac cgcgtccgcg acggggatcg gcgcgctgag cccgacccgc tcccacggcg
     9361 cggcgaacgc ccggggcatg cccgccatca ccgccatctc caggacgggc tcttcgggat
     9421 ggaggaggta gaccgcgccg gagtgcgcgt gcagctcctc gagcagggct gccagcgccg
     9481 gcgacagcag tggccggcgg ctgcgcgccg tggcgggcgc cggcgcccgc ccggcctccg
     9541 gcccgtcgga cacgccgacc acctcctcgt acggccgcgc gtcgctcccc gggattcaag
     9601 gctctctcgt gcggaccccc ggcgcacggc gagcggggac acctcgtacc gcccgtccgc
     9661 gacgcggggg tgcagacgtg ctcggccgcg ttcgggcggc cggggccggt gccgtgccgg
     9721 gagcccgcac aggggctgcg cgaccggctc atacgcgctg taatggcgaa gtggccagtg
     9781 agggcgccgc ggtgcgcaga acgaggacgg aacgcgcgga agtcgccctc tccacgctga
     9841 ccgccacgcc cgccgccccc gaccggctgc gccgcgtcct ggaacaggca ctggtcttcg
     9901 cgggagccgc gttcgccggg gtgtacatgc ccggcgacga ccccgccgtg ctgcgcctgg
     9961 ccgagtcggc cggcctgccc cgcacgctgt acggcctgcg cgacggctac gcggtgacca
    10021 gcgactccgt gatcgccgag gcgcaccgca ccggacggtc ggtgtggcgc agcccgcagg
    10081 aactggccgc ctgctccgag tcccgccgca ccccgtcccc ggacttctcc ctggccgccc
    10141 tgccgctcgg cccggccggc cgcggctgcc tcctcgccgt cagcgagcag ccgggcggct
    10201 tcggctcgga cgaccg
//
