LOCUS       NZ_KQ948855            21334 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces bungoensis strain DSM 41781 PRJNA299233_s005, whole
            genome shotgun sequence.
ACCESSION   NZ_KQ948855
VERSION     NZ_KQ948855.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces bungoensis
  ORGANISM  Streptomyces bungoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 433239)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces bungoensis DSM 41781, type
            strain for the species Streptomyces bungoensis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 433239)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.6x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001514215.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:15:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,539
            CDSs (total)                      :: 7,454
            Genes (coding)                    :: 7,226
            CDSs (with protein)               :: 7,226
            Genes (RNA)                       :: 85
            rRNAs                             :: 1, 1 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            tRNAs                             :: 80
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 237
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 237
            Pseudo Genes (frameshifted)       :: 67 of 237
            Pseudo Genes (incomplete)         :: 196 of 237
            Pseudo Genes (internal stop)      :: 10 of 237
            Pseudo Genes (multiple problems)  :: 43 of 237
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:26:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 242261
            Orig. end                         :: 263595
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ948855.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21334
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21334
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21334
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11334](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11334)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(200..214)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(233..248)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    complement(411..420)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(952..967)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            987..1694
                     /locus_tag="AQJ66_RS13550"
                     /old_locus_tag="AQJ66_13560"
     CDS             987..1694
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674421.1"
                     /locus_tag="AQJ66_RS13550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13560"
                     /product="ester cyclase"
                     /protein_id="WP_061920605.1"
                     /sec_met_domain="PF07366 (E-value: 1.5e-37, bitscore:
                     122.8, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFVQLIECRTSRLDEMNRLIDDWVAQTRGRRTATHALVAKDRSD
                     ASHIVEVVEFPSYEEAMRNSNLPETDRIFHDMVALCDEMPTFTDLEVVRDELLTEITVR
                     RFFEALQAPGELSPLNDLLDEDVHSHDPMNPQDTIGLDGVRSEYRMWRSAFDVSMTVED
                     VLAQGDRACARWTWNATHTGDFLGISPTGRHVSMTGLTMFRFGENGKIAELWWQHDQLG
                     LMQQVGALDELEQ"
     gene            1814..6238
                     /gene="pglW"
                     /locus_tag="AQJ66_RS13555"
                     /old_locus_tag="AQJ66_13565"
     CDS             1814..6238
                     /codon_start=1
                     /gene="pglW"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033442.0"
                     /locus_tag="AQJ66_RS13555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13565"
                     /product="BREX system serine/threonine kinase PglW"
                     /protein_id="WP_061920607.1"
                     /sec_met_domain="Pkinase (E-value: 5.4e-20, bitscore: 66.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAAPKPTAPAPRERWFQPRRSGFQWEQEGLDHLRGLMPKTEPFR
                     AWATFQFTAASGRVNECDVLIAVPGGLYLLELKGHPGRVVNHGDTWQFHGDRLRTLRNP
                     LHLTDLKAKELKGQLERAARTLGMSPKDVPFIKPAVFLHDPGLVSELDEFQRTAVYGRN
                     DGASGLPKIWDDLLGRPPERESWRITPVVSQRLERLMQRIGISHSTAHLRFGDDWKLEP
                     RALDAGPGWEDRLAVRDDGLVQESGRVRIYLAGAAASEEQRAKVDRAARREYQVLQGIN
                     HRGIVQAVQIREHQGGPAILFRHRESDLRLDAYLDAYGGHLTPGQRLDLVRQLAEAVRY
                     AHNRSLYHRALAARSVYVSAREDGSAPVLRIADWQTAARDFETTLHRSLGDTPLDGGLI
                     ADTAQVYLAPETNQEFADPVDLDVFGLGSLTYLLLTGRPPADRRSALLERLQSDGGLHP
                     YAVSDSVSAALDALVFRATAADVRDRLASVDEFLGLLGAAETDAAAPEPSAGPAADPLT
                     VQPGQPLDGTWSVVRVLGTGATARALLVRRGASEDGEQPLRVFKVALDQEKDARLLAEA
                     KALKEVGGGHIVKLLAEPRELAGHAVLEIEYAGGFRAEDDREPVSLGSRLRDQGPLGYD
                     QLERFGNDLFEALDTLAARGVRHRDIKPDNLGLFKRSDGSWQLMLFDFSLADAPDQDVH
                     AGTRGYLDPFLGGAGRSRYDDHAEWYAAAVTLHEMASGERPVWGDGQGDPRMVSDTAPH
                     VSAELFPQALSEGLKAFFERALHRDVEQRYDSLRQLQEAWRQVFRKADAARPATTPATV
                     GLSADDLEDAREQAAAAAGLRTPLAAAGLSPRAVSVAEGLKAHTVEELLDIPPHYISRA
                     RGAGNAIRKELNRRHRQWTQALRRKAAVKKSVAPLEPDAPEEVLESIDTLAARLTPPEG
                     KRRTRPRSDVVRATLQLPGVLEAGEPLEPWPAQSLIAKALGISQPTVSQNQQAAVEKWA
                     ALPWLGRIRDELVAILTDRDRVSTAEELAAELRARHGAGTADPAEAQAKALAVVRAAVE
                     TEMRKRDDDRPGAESADAGEAPPRFAVQRRGGRVVIALEDQPGADDPTPAELADHAAAL
                     GEQAADLAGRDPLPGRATVLRELRAIPTPEGMAPLADTRLVELAASMAGSVAVSPRLEL
                     FPLSLGLARALRISQAPAGVRPETGITTADLLARIRARFPGLAVPAETTYVELAEALVE
                     AGFPLSYDPDRRRFFPRAQDGNGSRLNLSSSMLTSTSSLYAAAQGRIAEGQDPREVLSA
                     RLTEARRRGGFLALTLKGAELPGVADALAERFGATAVPLNALFLDALKGLAEEQSVRWQ
                     ALLKADAKFTATGTLSAALASYTRLAAERVRERVLDLAERSGPRAVLLAHEAGLIARYW
                     EAGGRELLATLQQSARRPADTPHGLWLLLPVEDPRATPTLDGRTVEVVDRATEWEVLDG
                     LFVKSLRMDGAPS"
     misc_feature    6305..6319
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.66"
                     /tool="antismash"
     gene            6344..7609
                     /locus_tag="AQJ66_RS13560"
                     /old_locus_tag="AQJ66_13570"
     CDS             6344..7609
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQJ66_RS13560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQJ66_13570"
                     /product="hypothetical protein"
                     /protein_id="WP_159052560.1"
                     /transl_table=11
                     /translation="MKVGATLLGKRIAKVKPRRGGVQLVRLEALASFTCSRCAQTKSAR
                     SVAVRDDALLCNACYGNLQASDTGHDQSSPAGTGRTPEASVSPSEPGGRQSSALRTDNS
                     ARVVVQELDSGLPYSVANTGLRIEWKFHVRAEHLLHGTCPVPADMADRAAPHEPLDLTF
                     LRGRHRIRILDEQKNVRLRVRGGKAQLTGLTWQPFVLPGTRVSVGWDLWRKLRLAYTPL
                     DGPVVFGGTVVRYAYDPKIMTRELAAFDARVDRVEELVLIALRELGYLDEKGRALLPQE
                     ALIRNTIERAQSERPARRKIDGAIERLLSRGILTWEQGSINAAAMLHYPARRGETPVPL
                     LCYAPTLRDAEREDLRDDPGAGHGTSAHRVAGHLMRIGHLGKEASKEAKAAYREDHARA
                     GLAGPHEIPRGFTYVREHERGT"
     gene            complement(7710..8786)
                     /locus_tag="AQJ66_RS13565"
                     /old_locus_tag="AQJ66_13575"
     CDS             complement(7710..8786)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016777.4"
                     /locus_tag="AQJ66_RS13565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13575"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_061920611.1"
                     /transl_table=11
                     /translation="MLVSADSHVVEPPAVFRDYLDAEWRDQAPRLAPDHAGGERYVLPG
                     TTRSIGLGLAGSAGTPGKELRESGTAFADIRPGAWQPGPRLEDQDADGVAAEVLYPTVG
                     LFLLRHINRAYSAACMAAYNTWLAEFCAKAPDRLIGCGATAVTSPDSAVRDLRSIRGKG
                     LKGALLPLEPAEGFYADERFDALWAAACDLALPITFHALPPDRRAPAAGPGAAVILPLW
                     DAQELLTGLVFGGVLHRWPALRIVFAEFDAGWVPHLVQRLDHYFHRHHRWLKLDGRIHR
                     PPSEYIARAVHFTFQDDPTALRLALHSQTNLLWASDFPHAESTWPASRSLASAGSELLP
                     ARLYDEFFSTRARSLYGI"
     gene            complement(8791..9246)
                     /locus_tag="AQJ66_RS13570"
                     /old_locus_tag="AQJ66_13580"
     CDS             complement(8791..9246)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQJ66_RS13570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQJ66_13580"
                     /product="hypothetical protein"
                     /protein_id="WP_159052561.1"
                     /transl_table=11
                     /translation="MTLALLPLFIASWWQDWRSARTATSYFSGELVGFDALTAGNYVAL
                     VDGWRRPAPQGAWLSTATLISWAGVFAIYVAWNVAVMRKADQATRKAFLRFTLAELPLL
                     AIGIALIAVQTTVGWDIRWLQPVGVGLLAASHAALLVMWRVMSAKED"
     misc_feature    complement(9234..9246)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            complement(9361..9978)
                     /locus_tag="AQJ66_RS13575"
                     /old_locus_tag="AQJ66_13585"
     CDS             complement(9361..9978)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQJ66_RS13575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQJ66_13585"
                     /product="hypothetical protein"
                     /protein_id="WP_061920615.1"
                     /transl_table=11
                     /translation="MAAIAGISNTLIYVEKQLILPIGVKLVGSSLAARNSEQISGGFSW
                     FLAAKLGYAAEAGADMYLADLFPEDIFSFAYAEIERKNLGVRDFAEAVGSRQVTPPDVV
                     TIDGTLRFPDITPQAYDPFRPPAIQIPDQYSVYGYQCFTGVLENNGFEIPIYFLVESAE
                     LVFYAHNKPVEVVGVVKWSPGYEVAGHVLNGIVLAAALLLRR"
     gene            complement(10001..10351)
                     /locus_tag="AQJ66_RS13580"
                     /old_locus_tag="AQJ66_13590"
     CDS             complement(10001..10351)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Stand_Alone_Lasso_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQJ66_RS13580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQJ66_13590"
                     /product="PqqD family protein"
                     /protein_id="WP_061920617.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.9e-09,
                     bitscore: 31.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSIGALPRFTSRQEGDGFVILVQHSSRYLYANASAHELLDRLRS
                     GAPADEVVSAVATRYARDDDQARLLLAELVDVVNGRLERAGAAAGPAPSIRPLSDLLGE
                     SADRCETFGMPL"
     aSDomain        complement(10127..10306)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AQJ66_RS13580_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.10E-10"
                     /identifier="RREFam002.1"
                     /label="AQJ66_RS13580"
                     /locus_tag="AQJ66_RS13580"
                     /protein_end="75"
                     /protein_start="15"
                     /score="31.5"
                     /tool="antismash"
                     /translation="GDGFVILVQHSSRYLYANASAHELLDRLRSGAPADEVVSAVATRY
                     ARDDDQARLLLAELV"
     gene            complement(10369..11334)
                     /locus_tag="AQJ66_RS13585"
                     /old_locus_tag="AQJ66_13595"
     CDS             complement(10369..11334)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="AQJ66_RS13585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13595"
                     /product="radical SAM/SPASM domain-containing protein"
                     /protein_id="WP_061920619.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.5e-36, bitscore:
                     120.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.1e-21, bitscore: 70.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.7e-08, bitscore: 27.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.1e-08, bitscore: 29.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.6e-11, bitscore: 37.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALTAPLNVHWELTNLCNLNCVHCYQQDDGPRTGLPHADLLHVIS
                     RRIVEAGVFEVTLTGGEVLLVPQLQDIVTYFNSHGLRPHITSNGMLVTDEKADWLAAAD
                     VTFQVSLDAADPGRHNDVRRSPHAYDRALEGVTRLVERGVEVSFAYTAMPDNLQEIEGV
                     LAVAAERGVGRVCVGEVLPEFGDAANRRRLEIAAEPFGQFAAGLRELRERYRGRVDLAA
                     ALLSGHLHDQRLRASPCTALDRDLAILHDGWAYPCPFVRDRRRRLGDVRRHDLRTIWGG
                     AQAQRFREEKRTQSTKHCVSTAPPQGPVLVQLGTRPPTTE"
     gene            complement(11325..12542)
                     /locus_tag="AQJ66_RS13590"
                     /old_locus_tag="AQJ66_13600"
     CDS             complement(11325..12542)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014081.4"
                     /locus_tag="AQJ66_RS13590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13600"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_061920621.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.4e-25, bitscore:
                     84.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGATAGLGGELKGTFGGPLRHLNGLTVVDVRRGETRKASITLSQ
                     GRILALDEPAPEGAEIVDLDGCWATPSFVDMHAHVTFEPRTHDGAVTFAFDEPPEVGGL
                     RAVQNLTEALRNGICLVRDVGGRAPHMAEAKRHVASRHILLPELVTSGEPLCLPNGHGS
                     VFGQHLSQSTLDELVDRQAAAGHEWLKIMNGPELWPDEELERIIRSAHRAGMLTAVHAF
                     TPAGIRAAVRAGATTVEHGMVADPDLMEEAKGRSTVFVPTAYCSWISLRARFVMSQPAS
                     EVAILDYWHAYLEECRPAHIAAGLPVLVGTDAGCAPCSFDDYVDELLRFERWGIAPMEV
                     IRNATIRAAECLGRADDFGSIDVGKWANLVVTEHDPTVSPAALRHPTLVLYKGSSVVNA
                     LGERWP"
     misc_feature    complement(11394..11396)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12483..12485)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12539..13348)
                     /locus_tag="AQJ66_RS13595"
                     /old_locus_tag="AQJ66_13605"
     CDS             complement(12539..13348)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025054.4"
                     /locus_tag="AQJ66_RS13595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13605"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_061920623.1"
                     /transl_table=11
                     /translation="MSVSDPTVGDLLVFHFECLQGMYFSEYQRLEGGSLLFSDAIKDPY
                     YNFFAPGSPTAAAALPAAIEEEFVRRGRQPALYLTPQAAQADTSGAGRDVWATDAWLVG
                     DTAALAGPEGGDGNLRLRTVGREDREAYVATFTAAYSGDDPDDPYGDLDSAYSESLGAS
                     FGNEVPGYRKYYVLATLDEQPVGVAALFTAGGLAGVYGVGTLPGHRRAGIGSAIMRYLA
                     RIAETDGCAHIMLQTEARSAVQRWYERLGYRHVFDASYLTVAPEAGA"
     misc_feature    complement(13169..13171)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13533..16205)
                     /locus_tag="AQJ66_RS13600"
                     /old_locus_tag="AQJ66_13610"
     CDS             complement(13533..16205)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQJ66_RS13600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQJ66_13610"
                     /product="hypothetical protein"
                     /protein_id="WP_159052562.1"
                     /transl_table=11
                     /translation="MRGTRTDGGPVRPSTSGGVPTATLIRAGAAVLLAALCLCLPGAAR
                     AVASGGQEPKDRVGTITIEVGWDRSRQEVVIIETCSYTLAARSPGLAQARIDGVGRCDQ
                     PGVLRDRKVPDFDGARIRPDRVIQRSAHARAQVRSFFVLYLDRRSGEQKLTITPHPEAR
                     ADPRSGFPPDVWMVTVTAPKWSFSNVHGPVESQSADSVTWRVDTATGSGKEGPAVARSV
                     ELTRSVKTTRMPTARHQTRGEMLTAFALAGCGIGAVAALLVAGLAGPAVPRRWAAATLA
                     FAAVACACARSALPTPPLPPGTTHLDFFYASMPIPPAYTWSPGPVLGLWLWYVLPTAAW
                     WFTRRVVTGRPPSGPTLVASCVSPLLSLVLMAAGGTAWDTGAGARLVAAALAASALALS
                     GQRLRRGSAVRRWAPTAGALLWTVLVTWELARTPVIADGHAELSGWSAVAALVCTWPAA
                     AWLVSLLAPALRRTLGPAVRTACFLLLWVTLVAPFVVAYLPPTPLSRGNEAWYEYRHPL
                     FTDYAAFPFFVMTVCGIAVQIAYLWRRGARGDTGRAVEPVGRVLLVCAALTAFGAPNLR
                     TLTMWGEALAVLSASVASLVLLPIGSAASTARLRCVGRRGHARFMDRWLTTQLIWDTRA
                     DFQRSARSALAEDMTVSDFSDRWRGLAVPGRNGDPESRLRRAKRFALGTNAGRSPWTAG
                     LVGAGRAQLLALPWAVYKAVTSGTVGADNFMPFHLNLMFQILRFTHWALYGFVYGYFYA
                     MLRGLTPVGKAAWLMLGILPAEVLPMATLTVDPQYARDPSVNDLVTGCAGVAGQTLVLC
                     MLLGLWWEWSLARAAGMKWSQIRNFRRLSSITVPAGTVLVAGATAFATTIAGTWAQPDL
                     KPPGEVQSSQPAHPSEPAP"
     gene            16441..20217
                     /gene="pglX"
                     /locus_tag="AQJ66_RS13605"
                     /old_locus_tag="AQJ66_13615"
     CDS             16441..20217
                     /EC_number="2.1.1.72"
                     /codon_start=1
                     /gene="pglX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116003.1"
                     /locus_tag="AQJ66_RS13605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13615"
                     /product="BREX-2 system adenine-specific
                     DNA-methyltransferase PglX"
                     /protein_id="WP_061920627.1"
                     /transl_table=11
                     /translation="MTVTAEGTQGAGASLDRTRLLKDLQAQARLLEDDLRARTENEPGF
                     RDALRVEYEKAVAAERTAAMYETWRDERVVQIAAAWVLACVFVRFSEDNGLIPDAWLSG
                     PGDRLAEAQDRHDAYFRENPSKNDRDWLLDSFDALAKSHRTVEGLFDRAHNPLYEVTPS
                     YEAATALLAFWRKRGADGEIVHDFTDPELSTRFLGDLYQDLSEHARKTYALLQTPVFVE
                     EFILDLTLEPAVEEFGLTPAWKHRPAGWDGEVWADGPGGEEVVRGLRCIDPACGSGHFL
                     LGMFERLLGKWREAEPGTEPWVLVRRALESVHGADKNPFAVAIARFRLLVAALKAGGVR
                     ELSAAPGLPIRVAVADSLLHGRNLDTVTETFDTLFAEKEPFYYRTEDVEQYEREVDLLG
                     RGSYHVVVGNPPYITVKDSQENQNYRKPYFSCAGKYALSVPFAQRIFELAIRADTGSYD
                     GGFTGQITSNSFMKREFGKVLIEAYFHGGREYKDPSTGRKRDFSGVTLTHVIDTSGAFI
                     PGHGTPTVVLAGRNHKPRQADPIRAVLGVRGEPRQPDDPAKGLVWTAVKEQVGRPGSES
                     EWVSVENSERVRFANHPWSLSGGGAGTTKKRIETAAARTLGGFADSIGITSVTGEDDLY
                     LLPLNGAARRLQIATTQTLVTGDTIRDFSLEAEFESIWVYDSEYRTLPFAAVGSTRQLL
                     SDFRTAISSRKRFGVPMLKRGMAWHEWQELYPSKLRTQLSIPFAFVATHNHFVLDRGGK
                     VFKQSAPVIKLPEGAGEEQHLDLLGVLNSSAACFWLKQVSQGKGGSGVGCGIKDEAWEE
                     RYEFTGTKLQEFPLPKQLPLALGRELDSLAQESAKHAPSTLTDNAVPTREALDEARRAQ
                     EQIRARMIALQEELDWTVYGAYGLLTAEEVARTTTDDVPEVGLGQRAFEIVLARKVAAE
                     EAETAWFERHGSTPTTEIPAHWPEAYRKVVQARIDLIEANKDIRLIERPEYKRRWSIEP
                     WEKREASAIRNWLLDAAEREDLWFEERDGFTVPRPLTVNQLADALRHDKDVQAVAELYA
                     ADHLGKRDASLATVLAAVIDAEHVPYLAALRYKDSGLRKRAQWEQVWEQQREEDRTGQR
                     LDIKVPPKYTGADFLKHSYWSNRGKLDVPKERFISYPGASPDSDGSLLLGWAGWNHRDQ
                     ADALVGMIRDRVENGGWAKEDPRFVPLLAGLREVLPWVHQWHGEYDEEWEGNPAEEFQS
                     ALESGRTDRQLSESDLVNWRPEKKTGGRKKKSE"
     gene            complement(20262..20468)
                     /locus_tag="AQJ66_RS13610"
                     /old_locus_tag="AQJ66_13620"
     CDS             complement(20262..20468)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564862.1"
                     /locus_tag="AQJ66_RS13610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13620"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_061920628.1"
                     /transl_table=11
                     /translation="MKASSPEPAAGELSWFKSSYSSGSGGDCVEVADAGTAVLVRDSKR
                     PGEAFLSVGADEWAAFVRMAACG"
     gene            complement(20465..21304)
                     /locus_tag="AQJ66_RS13615"
                     /old_locus_tag="AQJ66_13625"
     CDS             complement(20465..21304)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564860.1"
                     /locus_tag="AQJ66_RS13615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_13625"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_061920629.1"
                     /transl_table=11
                     /translation="MESGADSGAGVEGEAGGEFLRCFGRQIKLLREQGGLTQAQLGERV
                     GYGEAQIAAVEQGRRIPKPDLIDAVDRVLGATGVLVAMKEEVAKARYPSFFRRYAEMEA
                     QAVELHAYDNHVVKGLLQTEEYARAVFTMWRPLLDPEVIEQRVAARLERQKLFSRRPTP
                     LLSFVVEEQVLRRPIGGRQVLRGQLEQLLLVGHERNVELQVMPTDRDEHAGLGGAFTLI
                     HLEGERRIGYMEVQEASILYTTPKKVSPLASTYGVLRAQALTPRESLAFIEKLLGEL"
ORIGIN
        1 acggctctga ttacgggatc gaccgcgggc atcggcgccg cgttcgcacg gcggcttgcg
       61 gctgacgggc acgacctcgt cctggtcgcg cgggacaccg ggcggctgcg cgagcaggcg
      121 accgaactgc acgaccggca cggcatcgag gcggaggtgc tgaccgccga cctcgccgag
      181 gacaagggca tcgagacggt ggccgaccgg ctcggcgacc ggcgcaaccc ggtcgaccta
      241 ctcgtcaaca acgccggctt cggcaacaag ggccgcttcc tggacgtgtc catggccgac
      301 gagctgagga tgctcaaggt gcactgcgag gcggtgctgc ggctgacctc ggcggcggcc
      361 gacgcgatgc gcgagcgcgg ccggggcggg atcgtgaacg tcgcctcggt ggccgccttc
      421 gtcccccggg gcacctacgg cgcctccaag gcctgggtcg tgcagttcac ccagggcgcc
      481 gcgaaggacc tggcgggcag cggggtgcgc ctgatggcgc tgtgccccgg cttcgtgcgc
      541 accgagttcc accagcgggc cgggatgggc acggacaaca tccctggctg gatgtggctg
      601 gacgcggaca agctggtcgc ggcggccctc gccgacctgg cccgggggag gaccgtctcc
      661 atccccgacc cgcggtacaa ggccctgatg ggcctggtga aggtcacgcc gcgcgggctg
      721 ctgggcgggg tcagctcccg gacggggcgc aagtacgggc cgaactgacg tccctcccga
      781 tcctcccctt cttgtgcggc ggggtcacga gcggccgcac agcctggcgc accagcgggt
      841 gggggacccg cccgccgacg ccgtccggcc tgggcccgcg cgggccgcgc gcaccgcccg
      901 gccaggctgt ggcgacagac ggcctgaacc gggaaaatgg ggcgtaccgg aagcggacca
      961 gaccagggga ccccggaggc ggcgccatga ccttcgtaca gctcatcgag tgccggacga
     1021 gccggctgga cgagatgaac cggctcatcg acgactgggt cgcgcagacc agggggaggc
     1081 ggacggcgac gcacgcgctg gtcgccaagg accgctcgga cgcgtcgcac atcgtcgagg
     1141 tggtggagtt cccgtcgtac gaggaggcga tgcgcaactc caacctcccg gagaccgacc
     1201 ggatcttcca cgacatggtc gcgctgtgcg acgagatgcc gaccttcacg gacctggagg
     1261 tcgtccgcga cgaactgctg accgagatca ccgtgcgccg cttcttcgag gcgctgcagg
     1321 caccgggcga gctgtccccg ctcaacgacc tgctggacga ggacgtccac agccacgacc
     1381 cgatgaaccc gcaggacacc atcggcctgg acggcgtccg cagcgagtac cggatgtggc
     1441 ggtccgcctt cgacgtctcc atgacggtcg aggacgtcct ggcccagggc gaccgcgcct
     1501 gcgcccgctg gacctggaac gccacgcaca ccggcgactt cctgggcatc tcccccaccg
     1561 gcaggcacgt ctccatgacc gggctgacca tgttccgctt cggcgagaac ggcaagatcg
     1621 cggagctctg gtggcagcac gatcagctgg ggctgatgca gcaggtgggg gcgctggacg
     1681 agttggagca gtaggccggt cccggatcag atgtcgtagg agcggactag gatttcggcc
     1741 gagtcgttga ggggggcacg caccgcgtcc tcgtgccctt cctcaggtcc tactgccgtt
     1801 ccggaggtgc tgggtgcccg ccgcccccaa gccgacagct cctgcccccc gtgagcgctg
     1861 gttccagcca cggcgatccg gattccagtg ggagcaggag ggcctggacc atctacgcgg
     1921 cctgatgccg aagacggagc cgtttcgggc gtgggcgacg ttccagttca ccgcggcgtc
     1981 gggccgggtc aacgagtgcg atgtgctcat cgccgtaccc ggcggcctct accttctgga
     2041 gctgaagggt caccccggca gggtcgtgaa ccacggcgac acctggcagt tccacggaga
     2101 ccggctgcgt acgctgcgca atcccctcca tctgaccgac ctcaaggcca aggagctgaa
     2161 gggacagctg gagcgggcgg cccgcacgct cggcatgagt cccaaggacg tcccgttcat
     2221 caagcccgcg gtgttcctcc acgacccggg gctcgtgagc gagctggacg agttccagcg
     2281 gaccgcggtc tacggccgca acgacggcgc gagcggcctg ccgaagatct gggacgatct
     2341 gctcggccgt cccccggagc gggagagctg gcgcatcacc ccggtcgtca gccagcggct
     2401 ggagcggctg atgcagagga tcggcatcag tcactccacc gcacacctgc ggttcgggga
     2461 cgactggaag ctcgagccgc gcgctctgga cgcgggcccc ggctgggagg accggctggc
     2521 cgtacgggac gacgggctgg tccaggagag cgggcgcgtc cgtatatacc tggcgggagc
     2581 ggccgcctcc gaggagcagc gcgcgaaagt ggaccgggca gcgcgccgcg agtaccaggt
     2641 gctgcagggc atcaaccacc ggggcatcgt gcaggcggtg cagatccgcg agcaccaggg
     2701 cggcccggcg atcctgttcc ggcaccgcga gtcggatctg cggttggacg cctatctcga
     2761 cgcgtacggc ggccacctca ctcccggtca gcggctcgac ctggtaaggc agctcgccga
     2821 ggcggtgcgc tacgcgcaca accggtccct ctaccaccgg gcgctggccg cacggtcggt
     2881 ctacgtctcg gcacgcgagg acggcagtgc ccccgtgctg cggatcgccg actggcagac
     2941 cgcggctcgg gacttcgaga cgaccctgca ccgctccctc ggggacacgc ccttggacgg
     3001 gggtctgatc gcggacacgg cgcaggtgta cctggcgccg gagacaaacc aggagttcgc
     3061 cgatccggtc gacctggacg tcttcgggct gggatcgctg acgtacctgc tgctcaccgg
     3121 ccggccgccg gcggatcgcc gcagcgcact gctggaacgg ctgcagagcg acggcggact
     3181 gcatccctac gcggtctccg actccgtctc ggccgccctc gacgccctcg tcttccgggc
     3241 gacggccgcc gacgtacggg accgtctggc atcggtcgac gagttcctgg gactgctcgg
     3301 tgcggcggag acggacgccg cggctccgga gccgagcgcg ggcccggccg ccgaccccct
     3361 cacggtgcag ccgggacagc cgctggacgg cacctggtcg gtggtccgcg tgctcggcac
     3421 cggcgccacc gcccgcgcgc tgctggtccg ccgcggtgcg agcgaggacg gggagcagcc
     3481 tctccgggtg ttcaaggtcg ccctggacca ggagaaggac gcccgtctgc tcgcggaggc
     3541 gaaggcgctg aaggaggtgg gcggcgggca catcgtgaag ctgctcgccg agccgcgtga
     3601 gctggccggt cacgcggtcc tggagatcga gtacgcgggc ggtttccgcg cggaggacga
     3661 ccgggaaccg gtgagcctcg gctcccggct gcgggaccag ggccccttgg gctacgacca
     3721 gttggagcgg ttcggcaacg acctgttcga ggcgctggac accctggcgg cgcgcggggt
     3781 gcggcaccgg gacatcaagc cggacaacct tggcctgttc aagcgcagcg acggctcctg
     3841 gcagctgatg ctgttcgact tctcgctggc cgacgccccg gaccaggatg tgcacgcggg
     3901 cacccgcggg tacctcgatc cgttcctcgg cggagcgggc cgctcgcgct acgacgacca
     3961 cgccgagtgg tatgcggctg ccgtgaccct gcacgagatg gcctccggtg agaggccggt
     4021 gtggggggac ggccagggcg acccgcgcat ggtgtccgac accgcgccgc acgtgtcggc
     4081 cgagctgttc ccgcaggccc tcagcgaagg cctgaaggcg ttcttcgagc gcgcgctgca
     4141 ccgggacgtc gagcagcgct acgacagtct gcgccagttg caggaggcgt ggcggcaggt
     4201 cttccgcaag gcggacgcgg cgcggcccgc gaccacgccg gcgacggtcg gcctgagcgc
     4261 ggacgacctg gaggacgccc gcgagcaggc ggccgcggcg gccggtctgc gaactccgct
     4321 ggccgccgcg ggcctgtcgc cgcgggcggt ttcggtcgcc gaggggctga aggcccacac
     4381 cgtcgaagag ctgctggaca tcccgccgca ctacatctcc cgtgcgcggg gcgcggggaa
     4441 cgcgatccgc aaggagctga accgccggca ccgccagtgg acgcaggcgc tgcgccgcaa
     4501 ggccgccgtc aagaagtccg tcgcgccgct ggagccggac gcgccggaag aggtcctgga
     4561 gtcgatcgac acgctggccg cgcgtctcac gccgcccgag ggcaagcgcc gcaccaggcc
     4621 ccgctccgac gtggtcaggg ccaccctcca gcttcccggc gtgctggagg ccggtgagcc
     4681 gctggagccg tggccggccc agagtctgat cgcgaaggcg ctgggcatca gccagccgac
     4741 cgtgtcgcag aaccagcagg ccgcggtcga gaagtgggcc gccctgccgt ggctcggccg
     4801 gatccgcgac gagctggtgg cgatactgac cgaccgggac cgggtgtcca cggccgagga
     4861 gctggcggcg gagctgcggg cccggcacgg tgcgggcacg gctgatccgg ccgaggccca
     4921 ggccaaggcg ctggcggtgg tgcgggccgc ggtcgagacg gagatgcgca agcgggacga
     4981 cgaccgtccc ggagccgagt ccgccgacgc gggcgaggca ccgccccgtt tcgccgtgca
     5041 gcggcgcggc ggccgggtcg tcatcgcgct ggaggaccag cccggcgccg acgatccgac
     5101 gccggccgaa ctcgccgacc acgcggcagc gctgggcgaa caggccgcgg atctggccgg
     5161 ccgcgacccg ctgcccggcc gtgccaccgt gctccgcgag ctgcgtgcga tccccacgcc
     5221 cgagggcatg gcccccctgg ccgacacgcg gctggtggag ctggcggcgt cgatggccgg
     5281 cagtgtggcc gtctcgccgc ggctggagct gttcccgctc tcgctcggtc tggcgcgcgc
     5341 cctgcgcatc tcgcaggcgc cggccggcgt ccgtcccgag accggcatca ccacggcgga
     5401 tctgctcgcg aggatccggg cccgcttccc gggcctcgcc gtgccggcgg agacgacgta
     5461 cgtcgaactg gccgaggccc tggtggaagc gggcttcccc ctgtcctacg acccggaccg
     5521 gcgccgcttc ttccccaggg cccaggacgg caacggcagc aggctcaacc tgtcctcgtc
     5581 gatgctgacc agcaccagct ccctctacgc cgccgcgcag ggccgtatcg ccgagggcca
     5641 ggacccgcgc gaggtactgt cggcacggct caccgaggcc cgtcgccggg gcggcttcct
     5701 ggcgctcacc ctgaagggtg cggagttgcc gggtgtggcc gacgcgctgg cggagcggtt
     5761 cggcgccacc gccgtgccgc tgaacgcgct gttcctggac gctctgaagg ggctggccga
     5821 ggagcagtcg gtgcgctggc aggccctgct gaaggcggac gccaagttca cggcgaccgg
     5881 cacgctgagc gcggcgctcg cctcctacac gcggctggcg gccgaacggg tgcgcgagcg
     5941 ggtcctggac ctggcggaac gctccggccc gcgcgcggtc ctgctcgcac acgaggccgg
     6001 cctgatcgcc cgctactggg aggccggcgg tcgtgagctg ctggccaccc tccagcagtc
     6061 cgcccgccgc cccgccgaca ccccgcacgg cctgtggctg ctgctgccgg tggaggaccc
     6121 gcgcgccaca ccgacgctgg acggccgcac ggtggaggtg gtggaccggg cgacggagtg
     6181 ggaggtgctg gacgggttgt tcgtgaagag cttgcgaatg gatggggcac cctcctgacc
     6241 gcccggtccg gcgttgcgcc atcactgggc cttgcccggc cgagccgaga aacctacgct
     6301 gatcgtctct ttctgaaatg ccgtgacatc cgggggggtt gtcatgaagg tcggggcgac
     6361 ccttctcggc aagaggatcg cgaaagtcaa gccgcgccgt ggtggcgtgc aactggtgag
     6421 gttggaggcg ctagcgtcct tcacctgctc gcggtgcgct cagacgaagt cagcacgatc
     6481 cgtcgcagtg cgcgatgacg ctctcctctg caatgcctgc tacggaaacc ttcaagcatc
     6541 agacacgggg cacgatcagt catcgccggc tggtacgggt cggacgccgg aagcctccgt
     6601 ctccccgtcg gagcctggtg gcaggcaatc gtcagccctt cggacggaca attccgcacg
     6661 ggtcgtcgtc caggaactcg acagcgggct cccctactcg gtcgccaaca ctgggctcag
     6721 aatcgagtgg aagtttcatg tgcgtgccga gcatctactg cacggcacgt gccccgtgcc
     6781 ggccgacatg gccgaccgag ccgcccctca tgagccgctc gacctcactt ttctgcgcgg
     6841 ccgtcaccgc atccggattc ttgacgaaca gaagaacgtc aggctccgtg tgaggggtgg
     6901 caaagcacaa ctgaccgggc tgacgtggca gcccttcgtc cttcccggga cacgcgtgtc
     6961 cgtgggatgg gacctgtgga ggaagctccg cttggcctac acccctctgg acggtcctgt
     7021 tgtcttcggt ggcaccgtcg tgcgctacgc ctacgacccg aagatcatga cccgtgaact
     7081 ggcagccttc gacgcccgcg tggaccgggt agaggagttg gtactgatcg ctctgcgcga
     7141 gctggggtac ctggacgaga agggccgggc actgctgccg caggaggcgc tgatccggaa
     7201 caccatcgag cgggcacagt cggagcgacc ggcgaggaga aagatcgacg gcgcgatcga
     7261 acggctcctt tcccgcggaa tcctcacatg ggagcagggc agcatcaacg ccgcagccat
     7321 gctgcactat ccggcacggc gcggggagac cccggttcca ctgctctgtt acgcgccgac
     7381 gcttcgagat gcggaacgcg aggacctgcg ggacgaccct ggagccggcc acgggacgag
     7441 cgctcaccgc gtggcaggac atctgatgcg catcgggcac ctcggcaaag aggcgagcaa
     7501 ggaggcgaaa gccgcctaca gagaggatca cgcacgagcg ggtttggcag ggcctcacga
     7561 gataccccgc ggcttcacct acgttcgtga gcacgagcga ggaacgtagc gcgggccagt
     7621 gaatcgcagg gccatgactt ctcgcgcggc acgttgccgt ggagggcacg agccgacgtc
     7681 acgacgtgta ctaccccgtc ggcgtcacct cagatgccgt acagggaacg tgcccgagtc
     7741 gagaagaact cgtcgtacaa ccgcgccggc aggagttcgg agccggccga ggccagcgac
     7801 ctggaggccg gccaggtgga ctcggcgtgc gggaagtcgc tcgcccacag cagattggtc
     7861 tgtgagtgga gcgcgagccg cagggccgtc gggtcgtcct ggaaggtgaa gtggacggca
     7921 cgggcgatgt actcggacgg cgggcggtga atccgcccgt cgagcttgag ccagcggtgg
     7981 tgccggtgga agtagtggtc caggcgctgc acgagatggg gcacccaacc ggcgtcgaac
     8041 tcggcgaaca cgatgcgcag tgcgggccat cggtgcagga caccgccgaa gacgagtccg
     8101 gtgagcagtt cctgcgcgtc ccacaggggc aggatcaccg cggcaccggg gcccgcggcc
     8161 ggcgcgcgcc ggtccggggg cagcgcgtgg aaggtgatcg gcagggcgag atcgcaggca
     8221 gcagcccaca gcgcgtcgaa ccgttcgtcg gcgtagaagc cctcggccgg ctccaacggc
     8281 agcagggcgc ccttcagtcc cttgccgcgg atcgaccgga ggtcacgcac agcgctgtcg
     8341 gggctcgtga cggcggtcgc gccgcatccg atcagcctgt ccggcgcctt ggcacagaac
     8401 tcggccagcc aggtgttgta ggccgccatg caggcagcgg agtaggcacg gttgatgtgg
     8461 cgcagcagga agagcccgac ggtggggtag aggacctcgg ccgccacccc gtcggcgtcc
     8521 tggtcttcga ggcgcgggcc gggctgccac gcgcccggcc ggatgtcggc gaacgccgtg
     8581 ccgctttccc gtagttcctt accgggggtg ccggccgacc cggcgagtcc cagtccgatc
     8641 gacctcgtgg tgccgggaag gacatagcgt tcgccgcccg cgtggtccgg cgcgagacgc
     8701 ggcgcctggt ctcgccactc cgcgtccagg tagtcccgga agacggccgg cggctcgacg
     8761 acatgggagt ctgccgagac gagcatgtcc ctagtcctcc ttcgcggaca tgacccgcca
     8821 catgacgagg agcgcggcgt gcgacgcggc caggaggccg acgccgaccg gttgcagcca
     8881 acggatgtcc cagccgacgg tcgtctggac ggcgatgagg gcgataccga tggccagcag
     8941 gggaagttcg gcgagggtga agcgcaggaa ggcttttcgg gttgcttggt ccgccttgcg
     9001 catcacggcc acgttccatg cgacgtagat ggcgaagaca ccggcccagc tgatgagcgt
     9061 ggccgtgctg agccacgccc cttgtggtgc cggacggcgc cagccgtcga ccagcgcgac
     9121 gtagtttccc gcggtgagtg cgtcgaaccc gaccagctca cccgagaagt acgaggtggc
     9181 ggtgcgcgcc gaccgccagt cctgccacca gctcgcgatg aagaggggca ggagtgccaa
     9241 cgtcaccgga gtcggtatgt cgtgcagcaa cagggagccg accacccagg gggtgacgta
     9301 gatgacgtcg accagcccga gggccggcgg tggcggacgg cgtcggatgg cagctcctcc
     9361 tcaccgtcga aggagcagtg cagccgcgag cacgattccg ttgaggacgt gccccgcgac
     9421 ctcgtaaccg ggtgaccact tgacgactcc cacgacctcc accggtttgt tgtgggcgta
     9481 gaacaccagc tcggccgact ccacgaggaa gtagatgggg atctcgaaac cgttgttctc
     9541 cagcactccg gtgaagcact ggtagccgta gacgctgtac tgatcgggga tctggatggc
     9601 cggcggccgg aacgggtcgt acgcctgcgg tgtgatgtcg gggaaccgca gcgttccgtc
     9661 gatggtcacc acgtcgggtg gcgtgacctg acgacttccg acggcctcgg cgaagtcccg
     9721 gacgccgagg ttcttccttt cgatctccgc gtacgcgaac gagaagatgt cctcggggaa
     9781 gaggtcggcc aggtacatgt ccgcacccgc ctcggccgcg tacccgagct tggccgcgag
     9841 gaaccagctg aagcctccgc tgatctgctc gctgttgcgc gcggcgaggg acgagcccac
     9901 cagtttcacg ccgatgggaa ggatgagttg cttctcgacg tagatgaggg tgttgctgat
     9961 gccggctatc gctgccaccg tctttctctg tcgggggtcg tcacaggggc atgccgaagg
    10021 tttcgcaccg gtcggcgctt tcacccagaa ggtcgctgag cggacggatg ctcggggccg
    10081 gcccggcggc tgcgcccgca cgttcgaggc ggccgttgac cacgtcgacc agttctgcca
    10141 gaagaagccg ggcctggtcg tcgtcccgtg cgtaccgtgt ggccaccgcg gagaccacct
    10201 cgtccgccgg ggcgccggag cgcagcctgt cgaggagttc gtgagcgctc gcgttcgcgt
    10261 acaggtaccg gctgctgtgc tgtaccagga tgacgaaccc gtcgccctcc tgccgtgagg
    10321 tgaacctggg cagtgcaccg atcgaggtca tgacgtctcc tagtctgcct actccgtggt
    10381 cggtggccgt gtgccgagtt gcacgagaac cgggccctgt ggaggagccg tgctcacgca
    10441 gtgtttcgtc gactgtgtgc gtttctcctc gcgaaagcgc tgggcctggg cgccgcccca
    10501 tatcgtgcgc aggtcgtgcc gccggacgtc gcccagacgc cggcgccggt ccctgacgaa
    10561 cgggcacggg taggcccatc cgtcgtgcag gatcgccagg tcgcggtcga gtgccgtgca
    10621 cggggaggcg cgcagacgct ggtcgtgcag gtgtccggac agcagcgccg ccgcgaggtc
    10681 gacccggccg cggtagcgct cgcgcaactc gcgcagtcct gccgcgaact gcccgaaggg
    10741 ctccgccgct atttcgagtc gccgccggtt ggcagcatcg ccgaactcgg gcagcacctc
    10801 gccgacgcag acccggccga ctccccgctc ggcggcgacg gcgagcactc cttcgatctc
    10861 ctggaggttg tcgggcatgg cggtgtaggc gaaggagacc tccacccccc gttcgacgag
    10921 ccgtgtcacg ccctccaggg ccctgtcgta cgcgtgaggc gaacggcgta cgtcgttgtg
    10981 gcgcccgggg tcggcggcgt ccaggctgac ctggaaggtg acgtcggccg cggcgagcca
    11041 gtccgccttc tcgtcggtga ccagcatgcc gttggacgtg atgtgcggtc gcaggccgtg
    11101 ggagttgaag taggtaacga tgtcttgtag ttgggggacg agcagcactt cgccgccggt
    11161 gagggtcacc tcgaacacgc cggcttccac gatgcgccgg gagatgacgt gcagcaggtc
    11221 ggcgtgaggc aggccggtgc gggggccgtc atcctgctgg tagcagtgca cgcagttgag
    11281 gttgcagagg ttggtcagtt cccagtggac gttcagcggc gcggtcaggg ccatctctcc
    11341 cccagggcgt tgacgacgct gcttcccttg tagaggacga gggtcggatg ccgtaacgcg
    11401 gccggcgaga ccgtcgggtc gtgttcggtg accaccaggt tggcccactt gccgacgtct
    11461 atggatccaa aatcgtccgc tcttcccagg cactctgcag ctcgtatggt ggcgttccgg
    11521 atgacttcca tgggcgcgat gccccagcgt tcgaatctga gcagttcgtc gacgtagtcg
    11581 tcgaaggagc agggcgcgca tccggcgtcc gtgccgacca ggacggggag ccctgcggct
    11641 atgtgggccg ggcggcactc ctcaaggtat gcgtgccagt agtcgaggat cgccacttcg
    11701 gacgccggct ggctcatgac gaaccgggca cgcagggaga tccatgagca gtacgcggtc
    11761 ggcacgaaga ccgtggagcg gcccttggcc tcttccatga ggtcggggtc cgcgaccatc
    11821 ccgtgctcca cggtggtggc gccggcccgg acggcggctc ttatcccggc gggggtgaac
    11881 gcgtggacgg cggtcagcat gcccgcgcgg tgagccgacc ggatgatccg ttccagctct
    11941 tcgtcgggcc acagctccgg gccgttcatt atcttcagcc actcgtgccc tgccgccgcc
    12001 tgccggtcca ccagctcgtc gagcgtgctc tgggacaggt gctgcccgaa caccgagccg
    12061 tgcccgttcg gcaggcagag cggctcaccg ctggtcacca gttcgggcag gaggatgtgc
    12121 cgggacgcca cgtgacgctt ggcctcggcc atgtggggcg cccggccgcc gacgtccctg
    12181 accaggcaga tgccgttgcg cagggcttcc gtcaggttct gcacggcacg cagtccgccg
    12241 acttcgggtg gttcgtcgaa ggcgaaggtg accgcgccgt catgggtccg gggttcgaac
    12301 gtgacgtggg cgtgcatgtc cacgaaggag ggtgtggccc agcaaccgtc caggtcgacg
    12361 atctcggcgc cctcgggagc gggctcgtcc agcgcgagga tcctgccctg ggagagggtg
    12421 atggatgcct tacgggtctc cccccggcgg acgtcgacca cggtgagccc gttcaggtgg
    12481 cgtaacgggc caccgaacgt tcccttgagc tctcccccga ggccggcggt ggcgccggtc
    12541 acgcacccgc ttccggtgcg acggtgaggt acgaggcgtc gaagacgtgc cggtagccca
    12601 aacgctcgta ccagcgctgg acggctgatc gggcctccgt ctgcagcatg atgtgcgcgc
    12661 acccgtccgt ctcggcgatg cgggctaggt accgcatgat ggcggagccg atgccggcgc
    12721 ggcggtggcc gggcagcgtg ccgacaccgt agacaccggc gaggccgccc gccgtgaaca
    12781 gcgcggccac ccctacgggc tgctcgtcga gggtcgccag tacgtagtac ttccggtaac
    12841 cggggacctc gttgccgaag gacgccccga ggctctcgga gtaggcgctg tccaggtcac
    12901 cgtaggggtc gtccgggtcg tctccggagt acgccgcggt gaaggtggcg acgtaggcct
    12961 cccggtcctc tcgcccgacg gtccgcaggc gcaggttccc gtccccgcct tccggcccgg
    13021 ccagtgccgc ggtgtcgccg acaagccacg cgtccgtggc ccagacatct ctcccggcgc
    13081 cggacgtgtc cgcctgcgcc gcctgcggcg tcaggtacag ggccggctgg cgcccgcgcc
    13141 ggacgaactc ctcctcgatc gcggccggta acgcggctgc ggcagtcggg gatccagggg
    13201 cgaagaagtt gtagtacggg tccttgatcg cgtcgctgaa gagcagagaa ccgccctcga
    13261 gccgctggta ctccgagaag tacatccctt gcaggcactc gaagtggaag acgaggagat
    13321 caccgactgt gggatcggag acggacatgt ccctcctgcg cgcagcgatg agccgacagg
    13381 gttccgacgg cccggtgggg cggcgaggga acactccacg ggatgaccga gagtagggag
    13441 attatggcgc aacgtcgcat accgagggaa ggattcgagc gatccgacgc ggcgccgtat
    13501 cggcaccgcc gctcggtgtc gcggcgactc gctcacggtg ccggttcgga ggggtgggcc
    13561 ggctgggagg actggacctc accgggcggc ttgagatcgg gctgcgccca ggtccctgcg
    13621 atcgtggtgg cgaaggcggt ggctccggcg acgagcaccg tgccggcggg gacggtgatc
    13681 gacgacagcc ggcggaagtt cctgatctgc gaccacttca ttccggcggc ccgggccagc
    13741 gaccattccc accagagccc cagcagcatg cacaggacga gcgtctgccc ggcgaccccg
    13801 gcgcaccccg tcaccaggtc gttcacggag ggatcccgcg cgtactgcgg atccacggtg
    13861 agggtcgcca tgggaaggac ctcggccggc aggatgccca gcatgagcca ggccgccttg
    13921 ccgacggggg tgaggccgcg cagcatcgcg tagaagtagc cgtagacgaa cccgtacagc
    13981 gcccagtgcg tgaaccggag tatctggaac atcagattca ggtggaacgg catgaagttg
    14041 tccgccccca cggttccgct ggtcacggcc ttgtacacag cccagggcag ggccagcagc
    14101 tgggcgcgtc ccgcgccgac gagcccggcg gtccagggac tgcgccccgc gttcgtgccg
    14161 agggcgaacc gtttggcccg cctcagcctc gactccggat cgccgttgcg cccgggcacg
    14221 gccagtccgc gccagcggtc ggagaagtcc gacaccgtca tgtcctccgc gagcgcggac
    14281 cgggcggacc gctggaagtc ggcccgggtg tcccagatca gctgggtcgt gagccagcgg
    14341 tccatgaaac gggcgtgccc ccggcggccg acgcatcgca gcctggccgt ggaggcagcc
    14401 gatccgatcg gcagcaggac cagcgaggcg accgacgcgg agaggacggc gagcgcttct
    14461 ccccacatcg tcagggtgcg caggttgggg gcgccgaacg ccgtgagcgc cgcgcacacc
    14521 agcagcaccc tgccgacggg ctccacggct cgcccggtgt cgcccctggc gccgcgccgc
    14581 cacaggtagg cgatctgcac ggcgatgccg cagacggtca tgacgaagaa cgggaaggcc
    14641 gcgtagtccg tgaacagcgg atgacggtac tcgtaccagg cctcgttccc acggctcagc
    14701 ggtgtgggcg gcaggtacgc caccacgaag ggggcaacca gcgttaccca gaggagcagg
    14761 aagcaggcgg tgcgcaccgc gggtcccaga gtgcgccgca gggcgggcgc caggagcgaa
    14821 acgagccagg ccgccgcggg ccaggtgcag accagggccg cgaccgcgct ccatccgctc
    14881 agctccgcgt gtccgtcggc gatgacgggg gtgcgggcga gttcccaggt gacgaggacc
    14941 gtccagagca gcgctccggc cgtgggagcc catctgcgca ccgcgctgcc cctgcgcagc
    15001 cgctgaccgg agagtgccag ggcggaggcg gccagtgccg ccgccaccag tcgggccccg
    15061 gcaccggtgt cccacgccgt cccaccggcc gccatgagga ccagggagag aagcggagac
    15121 acgcagctcg cgacgagtgt cggccccgag ggcggcctgc ccgtcaccac gcggcgggtg
    15181 aaccaccacg ccgccgtcgg caggacgtac cacagccaga ggcccagcac gggccccggc
    15241 gaccaggtgt aggccggcgg gatcggcatg ctggcataga agaagtcgag gtgtgtggtg
    15301 ccgggcggca agggcggggt gggcagggcg gagcgcgcac aggcgcacgc gaccgccgcg
    15361 aacgccaggg tggccgccgc ccacctgcgg ggcacggcgg gaccggccag accggccacc
    15421 aggagggcgg cgacggcacc aatgccgcag ccggcgagtg cgaacgcggt cagcatctcg
    15481 ccccgcgtct ggtgacgcgc cgtcggcatt ctggtggtct tcaccgaacg ggtcagctcg
    15541 accgagcgag cgaccgccgg tccttccttc cccgatcccg tcgcggtgtc gacccgccag
    15601 gtgacggagt ccgccgactg cgactcgaca gggccgtgga cattgctgaa cgaccacttc
    15661 ggcgcggtga ccgtcaccat ccacacgtcg gggggaaagc cgcttctcgg gtccgccctg
    15721 gcctccgggt gcggggtgat cgtcagtttc tgctccccgg accggcgatc caggtagagg
    15781 acgaagaagg accgcacctg tgcccgcgcg tgcgccgaac gctggatcac ccggtccggc
    15841 cggatcctgg caccgtcgaa gtccggcacc ttgcgatccc gcaggacccc gggttggtcg
    15901 cagcgtccga caccgtcgat ccgcgcctgg gccagtccag ggcttcgcgc ggcgagcgta
    15961 taggaacagg tctcgatgat caccacttcc tgccgcgacc ggtcccagcc gacctcgatg
    16021 gtgatcgtcc cgacccggtc cttcggctcc tggccgccgg acgccacggc ccgagcggca
    16081 ccgggaaggc acaggcagag cgcggccagc aggaccgcgg cacccgctct gatcagcgtc
    16141 gcggtcggca ctccgccgct cgtcgagggc cgcaccggcc cgccgtccgt acgtgtgcca
    16201 cgcacccgtg atcccccgcc cggcatgagc ctgtcgttgc gcgcccgtcg accgccgcga
    16261 accgggcgtg acgatgatgg cccccctcgc cgccggtcgg aggctcttcg ccgaaagacg
    16321 cacatgggga tggacgggac gcgggtgctg gcaggatggg acggcgggcc ttggggggct
    16381 cgcggggaat cgtgcgtccg cggtgatcgc ggggccgtga gcaggatgag aggtgcggct
    16441 gtgacggtga cggctgaggg gacgcagggg gcgggggcct cgctggaccg cacacggctg
    16501 ctgaaggatc tccaggcgca ggcccggctc ctggaggacg atctccgggc gcggaccgag
    16561 aacgagcccg ggttccggga cgccctgcgc gtcgagtacg agaaggccgt cgcggcggag
    16621 cgtacggcgg cgatgtacga gacgtggcgt gacgagcggg tcgtgcagat cgccgccgcg
    16681 tgggtgctgg cgtgtgtgtt cgtgcggttc agcgaggaca acggtctgat cccggacgcg
    16741 tggctgtcgg ggccgggtga ccggctggcc gaggcgcagg accggcacga cgcgtacttc
    16801 cgggagaacc cgtcgaagaa cgaccgcgac tggctgctgg actccttcga cgcgctggcc
    16861 aagtcccacc ggacggtgga ggggctgttc gaccgggccc acaatccgct gtacgaggtc
    16921 acgccgtcgt acgaggcggc gacggcgctg ctcgcgttct ggcggaagcg gggcgcggac
    16981 ggcgagatcg tccacgactt caccgacccc gagctgagca cgcggttcct gggtgacctc
    17041 taccaggacc tgtccgagca cgcccgcaag acgtacgcgc tgctccagac gccggtgttc
    17101 gtggaggagt tcatcctcga cctgacgctg gagccggccg tggaggagtt cggcctgacg
    17161 cccgcgtgga agcaccggcc ggcgggctgg gacggtgagg tgtgggccga cggtccgggc
    17221 ggcgaggagg tcgtccgggg gctgcgatgc atcgaccccg cgtgcggctc cgggcacttc
    17281 ctgctgggca tgttcgagcg gctgttggga aagtggcggg aggccgagcc ggggaccgag
    17341 ccgtgggtgc tggtgcggcg ggcgctggag tccgtgcacg gcgctgacaa gaacccgttc
    17401 gctgtggcca tcgcccggtt ccggttgctg gtggctgcct tgaaggcggg gggcgtgcgg
    17461 gagttgagtg cggcgcctgg gttgcccatt cgggtggctg tggcggactc gttgctgcac
    17521 gggcggaact tggacacggt gacggagacg ttcgacaccc tgttcgctga gaaggagccg
    17581 ttttactatc gaactgagga cgtagagcag tacgaacggg aggtagacct gctaggtcgg
    17641 ggctcctatc acgtggttgt ggggaacccg ccgtacatca ccgtgaagga cagccaggaa
    17701 aaccagaact atcggaaacc gtacttctcc tgtgctggca agtacgcact gtcggttccg
    17761 ttcgcgcagc gcatcttcga gctggcgatt cgcgccgaca ccggttccta cgacggaggt
    17821 ttcaccggtc agatcacgtc aaactccttc atgaagcggg agtttgggaa ggtcctcatc
    17881 gaggcttact tccacggtgg cagagagtac aaagatccga gtacgggccg gaaacgcgac
    17941 ttttcgggtg tcacactcac ccatgtcatc gacacatccg gtgccttcat tccggggcat
    18001 gggaccccga ccgtggttct ggccggacgt aaccataagc cccggcaggc cgacccgatc
    18061 cgggcagtac ttggcgtgcg cggcgaaccg cgccaaccag acgatccagc gaaagggctt
    18121 gtgtggacag cggtcaagga gcaggtgggg cggcctggga gtgagtcgga gtgggttagt
    18181 gtcgagaaca gcgaacgagt gcggttcgcc aaccaccctt ggtcgctgag cggcggagga
    18241 gcaggaacca ccaagaagcg catcgagacg gcggctgcgc gcactctcgg cggtttcgcg
    18301 gactcaatcg gcatcacgtc ggttaccggt gaggacgacc tctacctgct gcctctgaat
    18361 ggcgcggcgc gtcgtctcca gatcgccacc actcaaaccc tagtcacggg tgacacgatt
    18421 cgggatttct cactggaagc cgagtttgaa tccatctggg tctacgacag cgaatacagg
    18481 actcttcctt ttgccgctgt gggctccaca cggcagttgc tgagtgactt tcgtacggcg
    18541 atctcgtcac ggaagcggtt cggcgtaccc atgctgaaac gaggcatggc ttggcacgaa
    18601 tggcaggagc tgtatccaag taagctgcgc acccaactgt cgatcccctt cgccttcgtg
    18661 gccacgcaca accacttcgt gctggaccgg ggcgggaagg tgttcaagca gtccgcgcca
    18721 gtgatcaagt tgcctgaggg ggcgggtgag gagcagcatc tggacttgct gggggtgctc
    18781 aactcctcgg ccgcttgctt ctggctcaag caggtgagcc agggcaaggg cggcagcggc
    18841 gtcggatgcg gcatcaagga tgaggcttgg gaggagcgct acgagttcac cggaaccaag
    18901 ctccaggagt tcccgctacc caagcagctg cctcttgccc tcggtcgtga actcgactcc
    18961 ctcgctcagg agtcagccaa gcacgccccc tccaccctca ccgacaacgc tgtacccacc
    19021 cgcgaagctc tggacgaggc ccgccgtgcc caggagcaga tccgtgcccg catgatcgcc
    19081 ttgcaggaag agctggactg gaccgtctac ggcgcctatg ggctgctcac cgccgaggag
    19141 gttgctcgga ccaccaccga cgacgtaccg gaagtcggcc tcggtcaacg tgccttcgag
    19201 attgtgctcg ctcgcaaggt ggccgctgag gaagccgaga ccgcctggtt cgagcggcac
    19261 gggtccaccc ccaccaccga gatccccgcc cactggcccg aggcctaccg caaggtcgtc
    19321 caagcccgta tcgacctcat cgaggccaac aaggacatcc gcctcatcga gcgtcccgag
    19381 tacaagcggc gctggtccat cgagccctgg gaaaagcgcg aggcctccgc gatccggaac
    19441 tggctgctcg atgctgccga gcgcgaagac ctgtggttcg aggagcggga cgggttcacc
    19501 gtgccccggc cgctcaccgt caaccagctc gccgacgccc tgcgccacga caaggacgtc
    19561 caggccgtgg ccgagctgta cgccgccgac cacctcggca agcgcgacgc ctccctcgcc
    19621 accgtcctcg cggccgtgat cgacgccgag cacgtgccgt accttgcagc cctccgctac
    19681 aaggactccg gtctgcgtaa gcgggcccaa tgggagcagg tctgggagca gcagcgcgag
    19741 gaggaccgta ccgggcagcg gctcgacatc aaggtgccgc cgaagtacac cggcgcggac
    19801 ttcctcaagc actcctactg gtccaaccgc ggcaagctcg acgtgccgaa ggagcggttc
    19861 atctcctacc ccggtgcctc ccccgactcc gacggctctc tgctcctcgg ctgggccggc
    19921 tggaaccacc gcgaccaggc cgacgccctc gtcggcatga tccgcgaccg cgtggagaac
    19981 ggcggctggg ccaaggagga cccccgcttc gtaccgctgc tcgccggtct gcgcgaggtg
    20041 ctgccctggg tccaccagtg gcacggcgag tacgacgagg agtgggaggg caaccccgcc
    20101 gaggagttcc agtccgccct ggagagcggc cgtacggacc gccagctctc cgagtccgac
    20161 ctcgtcaact ggcgccccga gaagaagacc ggcgggcgca agaagaagag cgaataagcg
    20221 gagaggggcg gtcgactgcc gaccgcccct ccttgctcac ctcagccgca cgcggccatc
    20281 cgtacgaacg cggcccactc atcggcgccg acggagagga acgcctcccc cggccgcttg
    20341 gagtcacgga ccagcacggc cgtaccggcg tccgcgacct cgacacagtc tccgccgctg
    20401 cctgagctgt aactgctctt gaaccagctc agctcgccag cggcaggctc ggggctgctt
    20461 gccttcatag ctctcccaac agcttctcga tgaaggccag cgactccctg ggagtcagcg
    20521 cctgcgctcg gagaacgcca tacgtcgatg ccaaaggact gaccttcttg ggcgtggtgt
    20581 acaggatgct cgcctcctgc acctccatat agccaatcct gcgctcgcct tcgagatgga
    20641 tcaacgtgaa tgcgccgcca agccctgcat gttcgtcgcg gtcggtaggc atgacctgca
    20701 actccacgtt gcgttcgtgc ccgacgagca gcagttgctc cagttggcca cgcagcactt
    20761 ggcgaccgcc gatggggcgc cgaagtacct gttcctcgac gacgaagctc agaagcgggg
    20821 taggtcgccg tgagaacagt ttctgccgct ccagtcgtgc ggccactcgc tgctcgatga
    20881 cttcggggtc caacagcgga cgccacatgg tgaagaccgc acgcgcgtat tcctccgtct
    20941 gcaacaggcc cttgaccacg tggttgtcgt aggcgtgcag ttcaacagcc tgcgcctcca
    21001 tctccgcgta acgccggaag aacgacggat accgagcctt cgccacctcc tccttcatcg
    21061 ccaccagcac gcccgtcgcc cccagcaccc gatccaccgc atcgatcagg tccggcttgg
    21121 gaatgcgccg cccctgctcc accgccgcga tctgcgcctc gccgtagccg acccgttccc
    21181 ccaactgcgc ctgggtgagg ccgccctgtt cccgcagcag cttgatctga cgcccgaagc
    21241 accgcaggaa ctccccgccg gcctccccct ccacccccgc gcccgagtcc gcccccgact
    21301 ccatacgacc ctcctcaccc aacgctcacc gtcc
//
