LOCUS       NZ_KQ948852            22155 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces bungoensis strain DSM 41781 PRJNA299233_s002, whole
            genome shotgun sequence.
ACCESSION   NZ_KQ948852
VERSION     NZ_KQ948852.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces bungoensis
  ORGANISM  Streptomyces bungoensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 710746)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces bungoensis DSM 41781, type
            strain for the species Streptomyces bungoensis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 710746)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 60.6x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001514215.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:15:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,539
            CDSs (total)                      :: 7,454
            Genes (coding)                    :: 7,226
            CDSs (with protein)               :: 7,226
            Genes (RNA)                       :: 85
            rRNAs                             :: 1, 1 (5S, 16S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            tRNAs                             :: 80
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 237
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 237
            Pseudo Genes (frameshifted)       :: 67 of 237
            Pseudo Genes (incomplete)         :: 196 of 237
            Pseudo Genes (internal stop)      :: 10 of 237
            Pseudo Genes (multiple problems)  :: 43 of 237
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:26:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 453972
            Orig. end                         :: 476127
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ948852.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22155
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22155
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22155
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12155](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12155
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    332..346
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     misc_feature    447..461
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.0"
                     /tool="antismash"
     gene            complement(949..1410)
                     /locus_tag="AQJ66_RS06265"
                     /old_locus_tag="AQJ66_06270"
     CDS             complement(949..1410)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357668.1"
                     /locus_tag="AQJ66_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06270"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_061917781.1"
                     /transl_table=11
                     /translation="MTSTQRADTDTDLDVGDLTRAIENFNRYYIRLPAVQKLSFTTLSV
                     LDTLASSGPKRLTELARTEQISQPGLTQLVTRLERDGLVERRPDPADGRAALIRLTESG
                     RRIGQARHEDRGRHLIPLIAQLTPAERQAIAAALPALTRLAQLGTEARR"
     misc_feature    1546..1561
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.07"
                     /tool="antismash"
     gene            1550..2554
                     /gene="gap"
                     /locus_tag="AQJ66_RS06270"
                     /old_locus_tag="AQJ66_06275"
     CDS             1550..2554
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0019682 - glyceraldehyde-3-phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011559801.1"
                     /locus_tag="AQJ66_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06275"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="WP_061917784.1"
                     /transl_table=11
                     /translation="MTVRIGINGFGRIGRNVFRAAAGRTSELEIVAVNDLGDVPTMAHL
                     LAYDSILGRFPEEITAEPGAIRVGDRTIKVLAERDPGALPWGDLGVDIVIESTGIFTDA
                     AKARAHVDGGAKKVIIAAPGSGEDITLVMGVNDGDYDPERHTIISNASCTTNCLGVLAK
                     VLHDAVGIDSGMMTTVHAYTQDQNLQDAPHKDLRRARAAALNIVPTSSGAAKAIGLVLP
                     ELAGRLDAFALRVPVPTGSVTDLTVTTRRGTTVDEVKEAYAAAASGPYKGLLSYVDAPL
                     VSTDIVGDPASCVFDAGLTRVSGPQVKVVGWYDNEWGYSNRLIDLSLLVGSSL"
     misc_feature    complement(1555..1573)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            2744..3940
                     /gene="penM"
                     /gene_synonym="pntM"
                     /locus_tag="AQJ66_RS06275"
                     /old_locus_tag="AQJ66_06280"
     CDS             2744..3940
                     /EC_number="1.14.19.8"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016636 - oxidoreductase activity, acting
                     on the CH-CH group of donors, iron-sulfur protein as
                     acceptor [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="penM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000059: Other (88% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="pntM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182237.1"
                     /locus_tag="AQJ66_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06280"
                     /product="pentalenolactone synthase"
                     /protein_id="WP_061917787.1"
                     /sec_met_domain="p450 (E-value: 7.9e-19, bitscore: 63.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKELPQLPFDNPDILGIAPQMRALQRQGPITRVQAAGEDAWLVTR
                     YDEVKALLADRRLSLSNPNPQPSAKSAARAFMVALMAGDDHETEAVRHARMRALLVPRF
                     TTRRMRLMKTRIEHHVDELLDKLAASAPPVDLHRALSFPLPTMTVCDLLGVPLADRERF
                     GQWARGTFDQSDNQHSANTFQQVVDYTTELVARKRIEPGDDILSELIAAEDGALSDAEI
                     AQLGNAVLLFGYETTIVRIDLGTLLLLRNPDQRALLAEKPELAPAAVEEILRLGVGGKG
                     SNALIPRYAHSDITVGETVIRTGDAVMLAIGAANYDGRAYPDGDLFDLTRDKPKSHLAF
                     GHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLHWQEHRITGGFDEIPVTF"
     misc_feature    2762..2764
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4008..4859
                     /gene="ptlH"
                     /gene_synonym="penH; pntH"
                     /locus_tag="AQJ66_RS06280"
                     /old_locus_tag="AQJ66_06285"
     CDS             4008..4859
                     /EC_number="1.14.11.35"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penH; pntH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182238.1"
                     /locus_tag="AQJ66_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06285"
                     /product="1-deoxypentalenic acid 11-beta-hydroxylase"
                     /protein_id="WP_061917789.1"
                     /sec_met_domain="PhyH (E-value: 4.7e-19, bitscore: 64.8,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTFSDYVDCTPLLDDRAALDRFYDEHGYVYLRGALDRELVRTA
                     AEQMLEGLIALGHATPGTTLDTLAIESFEAVDEVAMHDYVKYDELWNHPTTVKVWEKVF
                     GEPVFVFKSTTIRYYPSAAGAAAPSFLTPLHQDGFYIGPNKDFRTAWIPLLPTTLDIGG
                     VALADGSHRKGPREHVVTEDFRRFGHPVRGIPAQEFGADEQLLFSPMEPGDVLLFHAFM
                     CHKSLPNVSVHPAGMRMSMDTRVQPAASHRGFNALTPWTESAKDASKGIMSKITGTPTT
                     TE"
     misc_feature    4864..4876
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            4926..6380
                     /locus_tag="AQJ66_RS06285"
                     /old_locus_tag="AQJ66_06290"
     CDS             4926..6380
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358326.1"
                     /locus_tag="AQJ66_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06290"
                     /product="MFS transporter"
                     /protein_id="WP_061917792.1"
                     /transl_table=11
                     /translation="MTKREGLPPLQRPHATPEPSAGTKPAAAGLSGLALVVVLTGYALS
                     IVDASIVNVALTPISDDLHGGAAALELVVSGYGLTYALGLVLGGRLGDAFGRRRLYAYG
                     LAAFTVTSALCGLAPTIEFLVAARLLQGAGAAMLVPQVLATIQAATEGQARARAIGMYG
                     ATAALGMVTGQILGGLLVSLDVAGMGWRSVFAINVPIGVAALLAVRRVPATRADAKPGF
                     DPVGTVLFGLTVVCVLAVVVAGPDLGWPLWLWALLVVAAVGAVALVRAERGLEARGGSP
                     LLSPTVLSHQGMRRGLAAMVPFSAGFGAFLFVYALVAQGHFGFDGLASGAVLTPFAAAF
                     FAVTLFTPKIAAALGGRIVTLGALVQGAGVLLLALVIRLGWPHPSLALVLVGIGLFGVG
                     AALTGPTLFRMILADVPPAQAGMGSGVLVTSQQMATALGATVGGTLYVSVSGWLSTVSA
                     AVLVLALLGCFTVTVLVISLKLPDPR"
     gene            6472..7299
                     /gene="ptlF"
                     /gene_synonym="penF; pntF"
                     /locus_tag="AQJ66_RS06290"
                     /old_locus_tag="AQJ66_06295"
     CDS             6472..7299
                     /EC_number="1.1.1.340"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-176). E-value: 2.5e-11. Score:
                     35.7. Matches aSDomain:
                     nrpspksdomains_AQJ66_RS06290_PKS_KR.1"
                     /codon_start=1
                     /gene="ptlF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penF; pntF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182240.1"
                     /locus_tag="AQJ66_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06295"
                     /product="1-deoxy-11-beta-hydroxypentalenate dehydrogenase"
                     /protein_id="WP_061917795.1"
                     /sec_met_domain="adh_short (E-value: 2.1e-30, bitscore:
                     101.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSTTQAAVVTGAASGIGLALSARFARAGAGVVMADVDGDALHRR
                     AAELTAQGARVTAVTADLTDPDAVGRLADTAFDALGDIDVVCNNAGVLGPVGQPLWEVP
                     LERMRQVFEVNHWAHVLVARAFVPRLLERGRPAHLIHTASMSAFVVGAGSAAYAASKHA
                     DLAVARSLRADLRGTGVRVSVLCPGRVDTPMVEGLTAPRGAGGDTTVSAEDVAGLVWDA
                     LGSDRFYLFSNADAPRRLRDQFDDVWRHVPLPPPSPEEELWPAPKATTVATKH"
     CDS_motif       6496..6636
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQJ66_RS06290_0001"
                     /evalue="5.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AQJ66_RS06290"
                     /protein_end="55"
                     /protein_start="8"
                     /score="12.7"
                     /tool="antismash"
                     /translation="VVTGAASGIGLALSARFARAGAGVVMADVDGDALHRRAAELTAQG
                     AR"
     aSDomain        6496..6999
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQJ66_RS06290_PKS_KR.1"
                     /evalue="2.50E-11"
                     /label="AQJ66_RS06290_PKS_KR.1"
                     /locus_tag="AQJ66_RS06290"
                     /protein_end="176"
                     /protein_start="8"
                     /score="35.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVTGAASGIGLALSARFARAGAGVVMADVDGDALHRRAAELTAQG
                     ARVTAVTADLTDPDAVGRLADTAFDALGDIDVVCNNAGVLGPVGQPLWEVPLERMRQVF
                     EVNHWAHVLVARAFVPRLLERGRPAHLIHTASMSAFVVGAGSAAYAASKHADLAVARSL
                     RADLR"
     gene            7317..9071
                     /gene="ptlE"
                     /gene_synonym="penE; pntE"
                     /locus_tag="AQJ66_RS06295"
                     /old_locus_tag="AQJ66_06300"
     CDS             7317..9071
                     /EC_number="1.14.13.170"
                     /EC_number="1.14.13.171"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlE"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000057: Oxidation (93% identity)"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penE; pntE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182241.1"
                     /locus_tag="AQJ66_RS06295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06300"
                     /product="neopentalenolactone/pentalenolactone D synthase"
                     /protein_id="WP_079060117.1"
                     /transl_table=11
                     /translation="MREKYRQERDKRSTGRTYQFARGDFSRYARDPYTERREREPLTDE
                     VDVAVVGAGIGGLLTGAHLRKETGLERIRLIDEAGDVGGTWYWNRFPGVRCDVESYIYM
                     PLLEEIGTIPTEKYSTGPEIFAHLQKIARRYDLYRDALFQTTVTELRWDEAAARWLVGT
                     DRGDLFRARYVAMSIGLMHRPKLPALPGLDSFAGHSFHTSRWDFDYTGGDSTGGLTKLT
                     DKKVGVIGTGSTTVQLAPHLAEWAEQLVLFQRTPAAVDVRGNRPTPPGWADGLEPGWQQ
                     RRMENFHALTSGVPQDEDLVQDRWTQTTAKLAAAILPTGDRGGDPKERALAAERADFLK
                     MEELRARIDSVVTDPATAAALKPYYRVYCKRPCFHDGYLQTFNRPNVTLVDTQGRGVER
                     LTPAGVVANGREYPVDCLVFATGYEHEFAVPYTDRAGYDIVGRGGVKLSEKWADGARTL
                     HGLQVNGFPNCFILSKVQAGRHVNIAYMLGEQTRHLAHIVRCVEESGHQVVEASEAGEK
                     EWVEEILRLASNDLDFLENCTPGLYNNEGDPGGLPLLNSSYGGGSVEFVNILRRWREAG
                     DLAGLELR"
     misc_feature    7506..7508
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9105..10004
                     /gene="ptlD"
                     /gene_synonym="penD; pntD"
                     /locus_tag="AQJ66_RS06300"
                     /old_locus_tag="AQJ66_06305"
     CDS             9105..10004
                     /EC_number="1.14.11.-"
                     /EC_number="1.14.11.36"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (21-281). E-value: 4.8e-54. Score:
                     175.8. Matches aSDomain:
                     nrpspksdomains_AQJ66_RS06300_TauD.1"
                     /codon_start=1
                     /gene="ptlD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000058: Dehydration, Oxidation (89% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penD; pntD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182242.1"
                     /locus_tag="AQJ66_RS06300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06305"
                     /product="neopentalenolactone/pentalenolactone F synthase"
                     /protein_id="WP_061917801.1"
                     /sec_met_domain="TauD (E-value: 5.1e-53, bitscore: 175.8,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVTPIPGAALGAVVHGARVTGAMDETQVEEIWAALDAHLVLVFR
                     GHESPSYEEFLAFGRRFGYIPKTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAEWMGW
                     HTDYSFRPRVSQVGFLEAVEVPSSGGGETLFTDMYALYESLPPEERRRLHSYRVRHALR
                     TGYEETIEEELQGEVSLGESTAHIQPEDGTSTIHPLIARNPRTGRRSVYISTLNTRRIV
                     DLAPDDSRKLLDELLLHAGRPQYTYAHAWQPGDLVMWDQLGTVHAKRAFDPAERRVMRQ
                     VVSIFDDPADPWRAEAAA"
     aSDomain        9168..9947
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQJ66_RS06300_TauD.1"
                     /evalue="4.80E-54"
                     /label="AQJ66_RS06300_TauD.1"
                     /locus_tag="AQJ66_RS06300"
                     /protein_end="281"
                     /protein_start="21"
                     /score="175.8"
                     /tool="antismash"
                     /translation="GAMDETQVEEIWAALDAHLVLVFRGHESPSYEEFLAFGRRFGYIP
                     KTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAEWMGWHTDYSFRPRVSQVGFLEAVEV
                     PSSGGGETLFTDMYALYESLPPEERRRLHSYRVRHALRTGYEETIEEELQGEVSLGEST
                     AHIQPEDGTSTIHPLIARNPRTGRRSVYISTLNTRRIVDLAPDDSRKLLDELLLHAGRP
                     QYTYAHAWQPGDLVMWDQLGTVHAKRAFDPAERRVMRQ"
     gene            10001..11014
                     /locus_tag="AQJ66_RS06305"
                     /old_locus_tag="AQJ66_06310"
     CDS             10001..11014
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182243.1"
                     /locus_tag="AQJ66_RS06305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06310"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_061917804.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-62, bitscore:
                     206.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPACLRHSRVTITPALRAAVDRLDHRSRHQAAYHFGWVTAGG
                     APTSADAGKAVRPALALLSAEAVGAPPEVALPGAVAVELVHNFSLVHDDLMDGDEERRH
                     RRTVWKLWGPSSAILTGDALLALAQEVLLDTGLPTAAPAARLLARTTRHLIRGQVQDLS
                     FEQRSRVTVEECVDMAAGKTGALLSASAAIGAVLAGAPEATVDALALYGDQVGVAFQLV
                     DDVLGIWGDPAVTGKPVHSDLRSRKKTLPVSHALNQDGPLGDELATWLTTRGEPDEEEL
                     RRVAGLVEAAGGRDWALAEAARRMALAEDALRGAELDAGARDELLALGRFVVDREV"
     gene            11142..12155
                     /gene="ptlA"
                     /gene_synonym="penA; pntA"
                     /locus_tag="AQJ66_RS06310"
                     /old_locus_tag="AQJ66_06315"
     CDS             11142..12155
                     /EC_number="4.2.3.7"
                     /GO_function="GO:0050467 - pentalenene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /gene_synonym="penA; pntA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358321.1"
                     /locus_tag="AQJ66_RS06310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06315"
                     /product="pentalenene synthase"
                     /protein_id="WP_061917807.1"
                     /sec_met_domain="T1TS (E-value: 4e-80, bitscore: 265.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFHIPLPSRQSPDHARADAEQLVWPRSLGLIKSEAAATRH
                     LRGGYADLASRFYPHATGADLDLGVDLMSWFFLFDDLFDGPRGENPEETKRLTDAVAAA
                     LDGPLPDTAPPIAHGFADIWRRTREGMTPAWCARSARHWRSYFDGYVDEAESRFWDTPY
                     DTAAEYLAVRRRTIGVQPTVDLAERAGRFEVPHRVFDSAVLSAMLQIAVDVNLLLNDIA
                     SLEKEEARGEQNNMVMILRRERGWSKDRSVTHIQSEVRVRLEQYLLLESCLPQVADIYR
                     LDEAEHQALERYRDNAVRTVIRGSYDWHRSSGRYDAEFALAAGAQGYLEELGSTAR"
     gene            12196..13590
                     /gene="ptlI"
                     /gene_synonym="penI; pntI"
                     /locus_tag="AQJ66_RS06315"
                     /old_locus_tag="AQJ66_06320"
     CDS             12196..13590
                     /EC_number="1.14.15.32"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0050467 - pentalenene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000060: Oxidation (92% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penI; pntI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182245.1"
                     /locus_tag="AQJ66_RS06315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06320"
                     /product="pentalenene oxygenase"
                     /protein_id="WP_061917809.1"
                     /sec_met_domain="p450 (E-value: 2.2e-81, bitscore: 269.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQTTFSAGTAPGALPVVGHALQMMRHPVNFMTSLSAHGDLVEI
                     RIGPTKAYVPTHPDLLRHVLTNDRVFDKGGVFYDRARDIAGNGLVTCPFADHRRQRRLM
                     QSAFTRGRLKRYAEAMRAEIEDTVSRWQDGMVVDAFPEMYGMALRTVARTLYSTPVSPG
                     LAAKVERSFDVVLNGLFRQMFLPAAIRRLPLPSQRRYRSNLDFLHDTTQRLIEDYRGSD
                     TEHDDLLAALLASRDDDGGRLGDTEIHDQVITVMAAGTETVAGTLTWVFYLLSQHPEIE
                     AALYDEIDTVLGGRAPDWDDLPNLSLADRIISETLRLHPPAWLFTRLTTSPTELAGRRL
                     PSGTTVVFSPAAVARYEEAFDDPARFDPDRWLPDRVAPAARHAYVPFGTGARKCIGDLY
                     ARTEATLGLATILGRWRVGCEPGMDIRPVPLATVYHPRRLRLRLDARTPRRMTSAVPAP
                     AGGDAA"
     gene            13749..14957
                     /locus_tag="AQJ66_RS06320"
                     /old_locus_tag="AQJ66_06325"
     CDS             13749..14957
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995033.1"
                     /locus_tag="AQJ66_RS06320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06325"
                     /product="phospholipase D-like domain-containing protein"
                     /protein_id="WP_061917812.1"
                     /transl_table=11
                     /translation="MILDGIPAAPAQHTRPDPAARKQRLRRRLERLIGVAATEGNDLVP
                     LRNGDAIFPAMLGAIRSAERTIDMMTFVYWRGQIARDFAGALADRARAGVRVRLLLDGF
                     GAKEIEGDLLELMDEAGVQVAWFRKPVWLSPFKQNHRCHRKALIIDEHTAFTGGVGIAE
                     EWCGDARNPGEWRDTHVQVRGPAVDGVAAAFAQNWAECHDELFDDRDRFTEHAQEGSSV
                     VQVVRGSASIGWQDMQTLIRVMLTSAEERFRLATAYFAPDTYFIDLLCETARRGVRVEI
                     LLPGPHTDQRACQLAGQHHYARLLEAGVHIRQYQPTMMHAKIITVDSVAALIGSTNFNR
                     RSMDHDEEVMLAVLDETFTASLDRDFDEDLRRSVEIDPTRWRRRPVLQRLREAAVMPIR
                     RFL"
     gene            15085..15588
                     /locus_tag="AQJ66_RS06325"
                     /old_locus_tag="AQJ66_06330"
     CDS             15085..15588
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991302.1"
                     /locus_tag="AQJ66_RS06325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06330"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_061918331.1"
                     /transl_table=11
                     /translation="MTGLSGSGNDRVSRPDDDLLSLASTIAEAVEGLAHLWSVAAQGAS
                     LQLSPHQLRALRILEAEPGLNLTGLAVGMDIGLPTASRLCDRLEAAGLLDRVLHPHKRR
                     EVQLHLTGQGRQVLAEVASRRSQALARVLAAMESAEREALRRGLQGFRSAQDDGPRGGG
                     GAGS"
     gene            complement(15598..16776)
                     /locus_tag="AQJ66_RS06330"
                     /old_locus_tag="AQJ66_06335"
     CDS             complement(15598..16776)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120234.1"
                     /locus_tag="AQJ66_RS06330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06335"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_244162759.1"
                     /transl_table=11
                     /translation="MNASEPLPSAEAQLRAAPPHALVATARRLLAERVGALEVTLLLAD
                     YGLTVLQPVSHLPHTGEPVPAHEGPAGSAFVQQRPVVEILREPAGHLVHLPIAVRGDRL
                     GVLCVRLPAGAADPDTVLQLGEFATALGHEVSTADRDTDLYLQARRTRRLTLAAEMQWQ
                     LLPARGSAREEYVIGAHLEPAYAIGGDNFDWSADADHLTLTVTDGMGKGIDAALLTSLA
                     VGALRNARRAGLTLADQACLADQAVHAQYGGKAYASTLLLRFDLATGTVTAVDAGSPQL
                     FRQRDGHTERIDLEAQFPLGMFEESEYTEQTFRVAPGDRLIVVSTGVHETRSAQGELFG
                     EGALRQILSATRPAPPHEAARAVVSGLIEHHGSSELMSDAAVVCLDWHGRPR"
     gene            complement(16866..17303)
                     /locus_tag="AQJ66_RS06335"
                     /old_locus_tag="AQJ66_06340"
     CDS             complement(16866..17303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145944.1"
                     /locus_tag="AQJ66_RS06335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06340"
                     /product="ATP-binding protein"
                     /protein_id="WP_061917815.1"
                     /transl_table=11
                     /translation="MTGSPSERLPIGSDADLARVRRRVRQAAAGVGFGLVQQTKLITAA
                     SELARNALVHGGGGHVELTRLTDGARRGLRLSFVDTGPGIRDVELALTDGYTSAGGLGL
                     GLSGARRLVQEFSLDSRPGRGTTVTITDWAAGLPSPRTGTP"
     misc_feature    17488..17503
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.24"
                     /tool="antismash"
     gene            complement(17550..18728)
                     /locus_tag="AQJ66_RS06340"
                     /old_locus_tag="AQJ66_06345"
     CDS             complement(17550..18728)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020120240.1"
                     /locus_tag="AQJ66_RS06340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06345"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_061917819.1"
                     /transl_table=11
                     /translation="MNRFEAAARALRTAAPDELLDAVRVVLTERYQALDVDLFMADYGL
                     TVLQAVSGVPLRTPEPLPVHAGPAGRAFGAQEPYCEERRDGRARLHLPVSVRGDRLGVL
                     SVTLPSGDTARACEAELAELADVLGREVLVAERDTDLYLQARRRDRLTLAAEMQWQLLP
                     GRSCSRPEYDLGAQLEPAYAIYGDNFDWSVKADHLMLYVTNGMGEGIEASLLTNLAINA
                     LRNARRAGLSIADQAALADQAVYAHYRGRCYLSVLMFDFDLTTGRASVVDAGSPQLLRL
                     RGGEVERVDFDAQLPLGMFEETDYVAQEFQVQPGDRLLFVSDGVHEVASPKGEPYGEQA
                     LTRAIQSTRLLPAAEVPRALLRELTGHRGEAAVAEDDALVVCLDWRGRPGRA"
     gene            18929..19360
                     /locus_tag="AQJ66_RS06345"
                     /old_locus_tag="AQJ66_06350"
     CDS             18929..19360
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676951.1"
                     /locus_tag="AQJ66_RS06345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06350"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_061917822.1"
                     /transl_table=11
                     /translation="MTTTAVELLEVVWGRASTAPTSASQLRVLHILEHHDGINLRTLAE
                     SLASTPPSTSRLCDRLQAAGFVERVVGAEDRREVRLHLSGRGRSFLADLRARRERELRK
                     VLADMPAGKRVALLEGLEAFCATAATQIHGTADTDSRSA"
     gene            complement(19603..20130)
                     /locus_tag="AQJ66_RS06350"
                     /old_locus_tag="AQJ66_06355"
     CDS             complement(19603..20130)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004980330.1"
                     /locus_tag="AQJ66_RS06350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06355"
                     /product="TspO/MBR family protein"
                     /protein_id="WP_061917825.1"
                     /transl_table=11
                     /translation="MTTISEQARPIRSGAWTAAAAAAVTATAVAGARAVDADSAWYRSL
                     DKPSWQPPSWAFGAAWTPLYATIAWSAGRGLSRARGRERARLAASLAADLTLNAAWSHA
                     FFRRKSLWGGLAGTVLLDAANARLIRRTAGTDRPAAAALAPYAAWCLFATALNFSLLRR
                     NPEHRRAVPDQP"
     gene            20263..20646
                     /locus_tag="AQJ66_RS06355"
                     /old_locus_tag="AQJ66_06360"
     CDS             20263..20646
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676953.1"
                     /locus_tag="AQJ66_RS06355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06360"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_244162760.1"
                     /transl_table=11
                     /translation="MHATPGMKMHVTRHEQTFVLTVRGEVDYDDAEDFDAAWEAADKAA
                     LPVTAVDLSQVTFADSMLLNALLQARIRHQAAGRDLVLLGPLRPAIHRLLAISGTIQLF
                     TISDVGVGDAGPGPGGDGANDAP"
     misc_feature    complement(20282..20296)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            20733..21182
                     /locus_tag="AQJ66_RS06360"
                     /old_locus_tag="AQJ66_06365"
     CDS             20733..21182
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374425.1"
                     /locus_tag="AQJ66_RS06360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06365"
                     /product="ATP-binding protein"
                     /protein_id="WP_061917828.1"
                     /transl_table=11
                     /translation="MVIPLGQQAVDERHRTAPLRYSAAWDTAGASVPDARQAVRTLLAR
                     AGHRPDRRPSQDAQLVVSELVTNALRHAPGPGALLLELASDATSLLIAVRDSSRRPPEV
                     QARDGGRVGGHGLHLVSRLCEQMHTVLLETGKQVMVRLSLEPGAE"
     gene            complement(21203..21418)
                     /locus_tag="AQJ66_RS06365"
                     /old_locus_tag="AQJ66_06370"
     CDS             complement(21203..21418)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544779.1"
                     /locus_tag="AQJ66_RS06365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06370"
                     /product="hypothetical protein"
                     /protein_id="WP_061917831.1"
                     /transl_table=11
                     /translation="MIVKKLHESGIRSEHAYAAAFASIGLSVISWCVSLSVEKKGEERA
                     DRWGIFVGEWAPTFFGLGLALHNYEK"
     gene            complement(21537..21932)
                     /locus_tag="AQJ66_RS06370"
                     /old_locus_tag="AQJ66_06375"
     CDS             complement(21537..21932)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.4"
                     /locus_tag="AQJ66_RS06370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQJ66_06375"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_063804019.1"
                     /transl_table=11
                     /translation="MTTLPPPEFTLDFVREPGTLTVRVRGDLDYDTSDDALDAVLEQLS
                     AGRAPRDVRLDFGELTWIDSTGLSTLLMIHRRTSTLGATLHLDNRPAVLERMLLMTNVL
                     DHLTAPAADERAGAELEEDGVSGAGAT"
ORIGIN
        1 gcgggccagc tcaagtcggc cggcgtggac ctcaacctgg cccccgtcgc ggacgtggtg
       61 ccggcgagcc tcggcacgcg caaccagccc atagggcgct actaccgcga gtacggccac
      121 acgcccgacg tcgtcgcctc gcacagcggg gcgttcgcgg ccgggttcaa gcaggcccgc
      181 gtgatgacca cgctcaagca cttcccgggg ctgggccggg tgaccggcaa caccgacacc
      241 accgcgaacg tcgtcgactc ggtgacgacg accaccagct cctacctcac gccgttcagg
      301 tccgggatcc aggccgggtc accgttcgtg atgatctcct cggccaccta cagcaagatc
      361 gacgcccgtc acatcgcggc gttctcgccc acggtgatcc gcaagctgct gcgcacccag
      421 ctcggcttca agggcgtggt catctcggac gacctcggac aggccgtcgc cgtccgggcc
      481 tacacgccgg cccagcgcgc ggtcggcttc ctgtcggcgg gcggcgacct ggtcctcacc
      541 gtgaagacct ccatcgtgcc cgcgatgacc caggcggtcg gctcgcggat gcggacggac
      601 gccgcgttcc gcgccggcgt cgccgacagc gtccaccgcg tcctcgccgc gaaggcgagc
      661 gccgggctgc tgagctgcgg ctgagcagcc ggacagcgcg ccggccggga catcaccggc
      721 cggcctgagc agtcgtcctg gcggggccgc cgcgtcgctc taccccgcgc gcgtccgccg
      781 tgccacctcg ggttcgcggc gggcgtcgcc gagatgccgg tgcagccgcg cgcgtccggc
      841 gcgcggacga cggtcgtcgt ccacctgctg ccggccctcc ccggcgcccg gccggccggg
      901 cgcttcgccg gtcggcgtgc gcggggcggt gtggccgttg ccggggccct accgccgcgc
      961 ctcggtcccg agttgcgcca ggcgggtcag ggcgggcagg gccgcggcga tcgcctggcg
     1021 ttccgcgggc gtcagctggg cgatcagcgg gatcaggtga cggccccggt cctcgtgccg
     1081 ggcctggccg atcctgcggc cgctctcggt gaggcggatg agggcggcgc gtccgtccgc
     1141 cgggtcgggg cggcgttcca cgagaccgtc gcgctccagc cgggtgacca gctgggtcag
     1201 ccccggctgg ctgatctgct cggttctggc cagttcggtc agccgtttcg gaccgctgga
     1261 ggccagcgtg tccagcacgg acagtgtcgt gaaggacagc ttctgcaccg cgggaagccg
     1321 gatgtagtag cggttgaagt tctcgatcgc cctggtgagg tcaccgacgt ccaagtcggt
     1381 gtccgtgtcg gcacgctgag tagaagtcac gctggaaatg tatcgcagac ttatataagc
     1441 tcctgatcga tcgcgtgccg gcgcctcatc cgggcgcacg gtttgcattg cacctcggcg
     1501 caacggtgcg tcatatggac ttgtagagcg ctaggtgagg agcacaccaa tgactgtgcg
     1561 aatcggtatc aacggcttcg ggcgcatcgg ccgcaacgtc ttccgcgcgg cggccgggcg
     1621 gacctcggag ctggagatcg tcgccgtcaa cgacctgggc gacgtgccca cgatggccca
     1681 cctgctcgct tacgactcga ttctgggccg cttccccgag gagatcaccg ccgagccggg
     1741 cgcgatccgc gtgggtgacc ggacgatcaa ggtcctcgcc gagcgcgacc ccggcgccct
     1801 gccctggggc gacctgggcg tggacatcgt gatcgagtcc accggcatct tcaccgacgc
     1861 cgcgaaggcg cgcgcacacg tcgacggcgg agccaagaag gtcatcatcg ccgctccggg
     1921 cagcggcgag gacatcacgc tggtgatggg agtgaacgac ggcgactacg accccgagcg
     1981 ccacaccatc atctccaacg cctcatgtac gaccaactgt ctcggcgtac tggccaaggt
     2041 gctgcacgac gcggtcggta tcgactccgg catgatgacc acggtccacg cctacacgca
     2101 ggaccagaac ctccaggacg ccccgcacaa ggacctgcgc cgggcccggg ccgcggccct
     2161 gaacatcgtg cccacctcca gcggcgccgc caaggccatc ggcctggtcc tgcccgaact
     2221 cgccggccgg ctggacgcgt tcgccctgcg ggtgcccgtg cccaccggct cggtcaccga
     2281 cctcacggtc accacccgcc gcggcaccac cgtggacgag gtgaaggagg cgtacgcggc
     2341 cgcggcctcg ggaccgtaca agggcctgct ctcctacgtg gacgcgccgc tggtcagcac
     2401 cgacatcgtg ggcgacccgg cctcctgtgt cttcgacgcc gggctcaccc gggtgtccgg
     2461 cccgcaggtc aaggtcgtcg gctggtacga caacgagtgg ggctactcga accgcctcat
     2521 cgacctgtca ctgctcgtcg ggtcgtcctt gtgatggctc ggtagtctcc cgccgatccg
     2581 gcgtctgccc cacccgcacg tcagcagcgg tcgtccgtcg aagcggcggc cgccgcttcg
     2641 gcgcgcccgt gcaccggcgc gcagcgcacc cggcgtcacc gatgccgtcg gcgtgcccgg
     2701 atgtccgacg aatcccctgc gcgacgccac gaggactgac cacatgaagg aacttccgca
     2761 gttaccgttc gacaaccccg acatactcgg catcgcaccc cagatgcgcg cactgcagcg
     2821 gcaggggccg atcaccaggg tgcaggccgc cggtgaggac gcctggctgg tcacccgtta
     2881 cgacgaggtc aaggcgctgc tcgccgaccg gcggctctcg ctcagcaatc ccaacccgca
     2941 gccgtcggcc aagagcgcgg cgagggcctt catggtcgcg ctgatggccg gggacgacca
     3001 cgagaccgag gccgtcaggc acgcgcggat gcgcgcgctg ctcgtgcccc ggttcaccac
     3061 gcgccgcatg cgtctgatga agacccggat cgagcaccat gtggacgagc tgctcgacaa
     3121 gttggccgcc agtgctccgc cggtcgacct gcaccgcgcg ctgtcgttcc cgttgccgac
     3181 catgacggtc tgcgacctgc tcggcgtgcc gctggccgac cgggagcggt tcgggcagtg
     3241 ggcgagaggc acgttcgacc agagcgacaa ccagcactcg gcgaacacct tccagcaggt
     3301 cgtcgactac acgacggaac tggtggcgcg caagcggatc gagccgggcg acgacatcct
     3361 gtccgagctg atcgccgcgg aggacggcgc actgtccgac gcggagatcg cccagttggg
     3421 caacgccgtg ctgctgttcg gctacgagac caccatcgtg cgcatcgacc tgggcaccct
     3481 gctcctgctg cgcaacccgg accagcgtgc cctgctggcc gagaagcccg aactcgcgcc
     3541 ggccgcggtc gaggagatcc tgcgcctcgg cgtcggcggc aaggggtcca acgcgctgat
     3601 accccgctac gcgcacagcg acatcaccgt cggcgagacg gtgatccgga ccggggacgc
     3661 ggtgatgctg gccatcggcg cggccaacta cgacggccgg gcgtatcccg acggcgacct
     3721 gttcgacctg acccgggaca agcccaagtc ccacctggcg ttcgggcacg gcgcccggca
     3781 ctgcatcggc cgcacgctgg cccggatcga gctgaccgcg gtgttcgagc ggctgttccg
     3841 cagactcccc gatctgcggc tcgccgtacc cgaggagtcg ctgcactggc aggagcaccg
     3901 catcaccggc gggttcgacg agattcccgt caccttctga gtggcgtcgc acgagcgaaa
     3961 agatccgacg ctccttcccc cacgcacagt cacgaggaca aggaaccatg acggacacct
     4021 tcagcgacta cgtcgactgc acgcccctgc tcgacgaccg cgcggccctc gaccggttct
     4081 acgacgagca cggctacgtc tacctgcgcg gcgccctgga ccgcgaactc gtgcggaccg
     4141 ccgccgagca gatgctcgag ggcctgatcg cactcggcca cgccaccccc ggcaccacgc
     4201 tcgacaccct tgccatcgag tccttcgagg ccgtcgacga ggtcgcgatg cacgactacg
     4261 tcaagtacga cgagctgtgg aaccacccca cgaccgtcaa ggtctgggag aaggtcttcg
     4321 gcgagcccgt cttcgtcttc aagtcgacga cgatccgcta ctacccctcc gccgcgggcg
     4381 ccgcggcgcc gagcttcctg acgccgctgc accaggacgg cttctacata ggcccgaaca
     4441 aggacttccg caccgcctgg ataccgctgc tcccgacgac cctcgacata ggcggcgtcg
     4501 ccctcgccga cggcagccac cggaagggcc cgcgcgagca cgtcgtcacc gaggacttcc
     4561 gccgcttcgg gcaccccgtg cgcggtatcc cggcacagga gttcggcgcg gacgagcagt
     4621 tgctgttctc acccatggaa ccgggcgacg tgctcctctt ccacgcgttc atgtgccaca
     4681 agtccctccc gaacgtctcg gtgcacccgg ccggcatgcg gatgtcgatg gacacgcgcg
     4741 tccagcccgc cgcctcgcac cgcgggttca acgccctgac gccctggacg gagtccgcga
     4801 aggacgcctc caaggggatc atgtcgaaga tcaccggcac tcccaccacc accgagtgac
     4861 ctcgtgacct cgtcaccccc gcacccgccc caaccgtccc ccacgaacgc ccgggtaggc
     4921 agctcatgac gaaacgcgag ggcctccccc ctctgcagcg gccccacgcg acaccggagc
     4981 cctcggccgg cacgaaaccg gccgccgccg ggctcagcgg cctcgctctc gtggtggtgc
     5041 tcaccggata cgccctgtcc atcgtggacg cctccatcgt caacgtggca ctgaccccga
     5101 tcagtgacga cctccacggc ggcgccgccg cactggaact ggtggtgtcc ggctacggcc
     5161 tgacctacgc cctcggcctg gtgctgggcg ggcggctggg cgacgccttc ggcagacggc
     5221 gcctgtacgc ctacgggctc gcggcgttca ccgtcacctc ggcgctgtgc ggactcgccc
     5281 cgaccatcga gttcctcgtc gcggcccggc tgctgcaggg cgccggcgcg gccatgctcg
     5341 taccgcaggt gctggcgacg atccaggcgg ccaccgaggg ccaggcgcgc gcccgcgcga
     5401 tcggcatgta cggcgcgacc gcggccctcg gcatggtcac cgggcagatc ctgggcgggc
     5461 tgctggtctc gctggacgtc gccgggatgg gctggcggtc ggtcttcgcg atcaacgtgc
     5521 cgatcggagt ggccgcgctg ctggccgtcc ggcgcgtccc cgcgaccagg gccgacgcga
     5581 agccgggctt cgacccggtg ggcaccgtgc tgttcggtct gaccgtggtc tgtgtcctgg
     5641 ccgtggtcgt ggcgggcccg gacctgggct ggccgctgtg gctgtgggcg ctgctcgtgg
     5701 tggccgcggt gggggcggtg gcgctggtgc gggccgaacg cgggctggag gcgcggggcg
     5761 gctcaccgct gctgtccccg acggtgctgt cccatcaggg gatgcgcaga gggctggccg
     5821 cgatggtgcc gttctcggcc ggcttcggcg ccttcctgtt cgtctacgcg ctggtcgcgc
     5881 agggtcactt cggcttcgac gggctcgcct ccggcgccgt gctgacgccg ttcgccgcgg
     5941 cgttcttcgc ggtgacgctg ttcaccccga agatcgcggc ggccctgggc ggccggatcg
     6001 tcaccctggg agccctcgtc cagggcgcgg gcgtgctgct gctggcgctg gtgatccggc
     6061 tgggctggcc gcacccctcc ctggcgctcg tgctcgtggg gatcggcctc ttcggcgtgg
     6121 gcgcggcact gaccggcccg acgctgttcc ggatgatcct cgccgacgtg ccccccgcgc
     6181 aggccggcat gggcagcggt gtgctggtga ccagccagca gatggcgacc gcgctgggcg
     6241 cgaccgtcgg cgggaccctc tacgtctccg tgtccggctg gctgtcgacg gtgtcggcgg
     6301 ccgtgctcgt cctcgccctg ctggggtgct tcacggtgac cgttctcgtg atcagcctga
     6361 aactccccga cccccgctga cacccgcgtc ccgcgatctg attccgacct tccccgtggc
     6421 aacggcgcgc ggccctcagg cgtacccgcg cgcagaagcg gagacagcga agtgcactca
     6481 acgacacagg cagccgtggt gaccggcgcg gccagtggca tcggcctcgc cctcagcgcc
     6541 cgcttcgcgc gggccggcgc cggcgtggtc atggcggacg tcgacggcga cgcgctgcac
     6601 cgccgggccg ccgaactcac cgcacagggc gcccgggtca ccgcggtgac cgccgacctg
     6661 accgatccgg acgccgtcgg ccggctcgcg gacacggcgt tcgacgcgct cggcgacatc
     6721 gacgtggtgt gcaacaacgc cggggtcctc ggccccgtgg gacagcccct gtgggaggtg
     6781 ccgctggagc ggatgcggca ggtcttcgag gtgaaccact gggcgcacgt cctggtggcc
     6841 cgcgccttcg tcccccggct gctggagcgc ggccggcccg cgcatctgat ccacaccgcc
     6901 tcgatgtccg ccttcgtcgt gggcgccggc agcgccgcct acgccgcctc caagcacgcc
     6961 gacctcgcgg tcgcccgcag tctgcgcgcc gatctgcggg gcaccggcgt ccgggtgtcg
     7021 gtgctgtgtc ccggccgggt cgacaccccc atggtcgagg gcctgacggc cccgcgcggc
     7081 gcgggcggcg acaccacggt gagcgccgag gacgtcgccg gactcgtgtg ggacgccctc
     7141 gggtccgacc gcttctacct cttcagcaac gccgacgccc cgcggcggct gcgcgatcag
     7201 ttcgacgacg tatggcgtca tgttcccctt ccgccccctt cccccgagga ggagctgtgg
     7261 cccgcgccga aggcgacgac cgtagcgacg aagcactgac catcgacctg gaggcggtga
     7321 gggagaagta ccgtcaggaa cgcgacaagc gcagcaccgg ccgcacctac cagttcgcgc
     7381 gcggtgactt cagccgctac gcgcgcgacc cctacaccga gcggcgggag cgcgagccgc
     7441 tcaccgacga ggtggacgtc gccgtcgtcg gcgccggcat cggcggtctg ctgaccggcg
     7501 cccacttacg caaggagacc ggcctggagc gcatccggct gatcgacgag gccggcgacg
     7561 tcggcggcac ctggtactgg aaccgcttcc ccggcgtccg gtgcgacgtc gagagctaca
     7621 tctacatgcc gctgctggaa gagatcggca cgatccccac cgagaagtac tccaccgggc
     7681 ccgagatctt cgcccacctc cagaagatag cccgcaggta cgacctgtac cgcgacgccc
     7741 tcttccagac caccgtcacc gagctgcgct gggacgaggc cgccgcgagg tggctggtgg
     7801 gcaccgaccg cggggacctg ttccgggccc ggtacgtggc catgtcgatc ggcctgatgc
     7861 accggcccaa actccccgcg ctgccgggcc tggactcgtt cgccgggcac tccttccaca
     7921 ccagccgctg ggacttcgac tacaccggcg gcgacagcac cggcggcctg accaagctga
     7981 cggacaagaa ggtcggcgtc atcggcaccg gctcgacgac cgtccagctc gcgccgcacc
     8041 tcgccgagtg ggccgagcag ctcgtcctct tccagcgcac cccggcggcc gtcgacgtcc
     8101 gcggcaaccg gcccaccccg cccggctggg cggacggcct ggaaccgggc tggcagcagc
     8161 gccggatgga gaacttccac gcgctgacct ccggcgtccc gcaggacgag gacctggtgc
     8221 aggaccgctg gacgcagacc acggccaagc tggccgccgc gatcctgccc accggcgacc
     8281 gagggggcga cccgaaggag cgggcactcg cggccgaacg agcggacttc ctcaagatgg
     8341 aggagctgcg cgcccgtatc gacagcgtcg tcaccgaccc cgcgaccgcc gccgccctca
     8401 agccgtacta ccgcgtgtac tgcaagcggc cctgcttcca cgacggctac ctccagacct
     8461 tcaaccggcc caacgtgacc ctggtcgaca cccaggggcg gggcgtggag cggctcaccc
     8521 cggccggcgt ggtcgcgaac ggccgggagt acccggtcga ctgcctggtc ttcgccaccg
     8581 gctacgagca cgagttcgcc gtcccctaca ccgaccgcgc cggctacgac atcgtcggcc
     8641 gcggcggcgt gaagctgtcg gagaagtggg cggacggagc gcgcaccctg cacggactgc
     8701 aggtgaacgg cttccccaac tgcttcatcc tgtccaaggt ccaggccggc cggcacgtca
     8761 acatcgccta catgctgggc gagcagaccc ggcacctcgc gcacatcgtc aggtgcgtcg
     8821 aggagagcgg ccaccaggtc gtggaggcgt ccgaggccgg cgagaaggaa tgggtcgagg
     8881 agatcctccg gctcgccagc aacgacctcg acttcctcga gaactgcacg cccggcctct
     8941 acaacaacga gggcgacccg ggcggactgc ccctgctcaa ctccagctac ggcggcggtt
     9001 cagtggagtt cgtgaacatc ctcaggcgct ggcgagaggc gggcgacctc gccggcctcg
     9061 aactgcgctg accccccacc cttctgcgaa aggaggcaac gcccgtggac gtgacaccga
     9121 tacccggcgc cgctctcggc gccgtcgtgc acggcgcccg agtcaccggc gcgatggacg
     9181 agacccaggt ggaagagatc tgggcggcgc tcgacgcgca tctggtcctc gtcttccgcg
     9241 gccacgagag cccgtcctac gaggagttcc tggccttcgg ccgccgcttc gggtacatcc
     9301 cgaagaccgg tctgaccagc ggcgcccacc ccgaccacaa cgagatcctg atcgtctcca
     9361 acctggtgga ggacggccgc aagatcggtg tcggcgacgc cgagtggatg ggctggcaca
     9421 ccgactactc cttccgcccc cgcgtctccc aggtcggctt cctggaggcc gtggaagtgc
     9481 cgtcctccgg tggcggggag accctcttca ccgacatgta cgccctgtac gagtcgctgc
     9541 cgcccgagga gcgccggcgg ctgcactcct accgggtccg ccacgccctg cgcaccgggt
     9601 acgaggagac catcgaggag gagctccagg gggaggtgtc cctcggcgag agcaccgcgc
     9661 acatccagcc cgaggacggc acctccacca tccaccccct catcgcccgc aatccgcgca
     9721 ccggccgccg gtcggtctac atcagcaccc tgaacaccag acggatcgtg gacctcgccc
     9781 ccgacgacag ccgcaagctg ctcgacgaac tgctgctcca cgcgggcagg ccccagtaca
     9841 cctacgccca cgcctggcag cccggggacc tcgtcatgtg ggaccagctc ggcaccgtcc
     9901 acgccaagcg ggccttcgac ccggccgaac ggcgcgtcat gcgccaggtc gtcagcatct
     9961 tcgacgaccc ggccgacccc tggcgcgcgg aggccgccgc atgagcaccg cccccgcctg
    10021 cctccgccac agccgggtca cgatcacccc ggcgctgcgc gccgccgtcg accggctcga
    10081 ccaccgctca cgtcaccagg cggcctacca cttcggctgg gtcaccgccg gcggcgcgcc
    10141 caccagcgcc gacgcaggca aggccgtacg gccggcgctc gcgctgctgt cggccgaggc
    10201 ggtcggcgca ccgccggagg tcgccctgcc cggtgccgtc gccgtggaac tcgtgcacaa
    10261 cttctccctg gtgcacgacg atctgatgga cggcgacgag gagcgccgcc accggcgcac
    10321 ggtgtggaag ctgtggggtc cctccagcgc catcctgacc ggcgacgcgc tgctggcgct
    10381 cgcccaggag gtgctgctgg acaccgggct gccgacggcg gcgcccgccg cccggctgct
    10441 ggcccgcacc acccggcatc tgatccgcgg gcaggtgcag gacctgtcct tcgaacagcg
    10501 ctcgcgcgtc acggtcgagg agtgcgtcga catggccgcc ggcaagaccg gcgcgctgct
    10561 gtcggcgagc gccgcgatcg gcgccgtcct cgccggggca ccggaggcga cggtggacgc
    10621 gctggcgctc tacggcgacc aggtcggcgt cgccttccag ctcgtcgacg acgttctcgg
    10681 catctggggc gacccggccg tcaccggcaa gccggtccac tccgatctgc gctcccgcaa
    10741 gaagaccctg ccggtgagcc acgcactgaa ccaggacggc ccgctcggcg acgagctggc
    10801 cacgtggctc accacccgcg gcgaacccga cgaggaggaa ctgcggcgcg tggccggcct
    10861 ggtcgaggct gccggcggcc gggactgggc gctggccgag gccgcccggc ggatggcgct
    10921 ggccgaggac gcgctgcgcg gtgccgaact ggacgccggc gcgcgggacg aactcctcgc
    10981 gctcgggcgg ttcgtcgtcg accgcgaggt ctgagaccgg gccgcccccg tacccgtacg
    11041 cccctttccc acctccgact ctccgatcgg cgcagcgacc cccgcccggg caccaccacc
    11101 gggccgctgc cctccgcaac ccacctccca aggactcccc catgccccag gacgtcgact
    11161 tccacatacc cctgccgagc cgccagagcc cggatcacgc ccgcgccgac gccgagcagc
    11221 tcgtatggcc gcgctcgctc gggctgatca agtccgaggc ggcggcgacg cgtcatctgc
    11281 gcggcggcta cgccgacctg gcctcccgct tctaccccca cgccaccggc gccgacctgg
    11341 acctgggcgt cgacctgatg tcgtggttct tcctcttcga cgacctcttc gacgggccgc
    11401 gcggcgagaa cccggaggag accaaacggc tcaccgacgc ggtcgcggcg gcgctggacg
    11461 gccccctccc cgacaccgcg ccccccatcg cccacggctt cgccgacatc tggcggcgca
    11521 cccgcgaggg catgacaccc gcctggtgcg cgcgcagcgc ccggcactgg cgcagctact
    11581 tcgacggcta cgtcgacgag gcggagagcc gcttctggga cacgccgtac gacaccgcgg
    11641 ccgagtacct ggccgtgcgc cggcggacca tcggggtgca gccgacggtc gacctcgccg
    11701 agcgcgcggg ccgcttcgag gtgccgcacc gggtcttcga cagcgccgtg ctctccgcga
    11761 tgctgcagat cgccgtcgac gtcaatctgc tgctcaacga catcgcctcg ctggagaagg
    11821 aggaggcccg cggcgagcag aacaacatgg tcatgatcct gcgccgggag cgcggctggt
    11881 ccaaggaccg cagcgtcacc cacatccaga gcgaggtgcg cgtccgcctg gagcagtacc
    11941 tcctgctgga gtcctgcctg ccgcaggtcg ccgacatcta ccggctcgac gaggccgagc
    12001 accaggccct ggagcgctac cgcgacaacg ccgtgcgcac cgtgatccgc ggttcctacg
    12061 actggcaccg ctcctcgggc cgctacgacg ccgagttcgc gctcgccgcc ggtgcccagg
    12121 gctacctgga ggagctcggc agcaccgccc gctaacggca cagcccacca gtagagacgg
    12181 gaagttgagg atcgaatgac cgagcagacc accttctcgg cgggaacggc gcccggggcg
    12241 ctccccgtcg tgggacacgc cctccagatg atgcgccacc ccgtgaactt catgacctcg
    12301 ctgtcggccc acggcgacct ggtcgagatc aggatcggcc ccaccaaggc ctacgtcccg
    12361 acccacccgg acctgctgcg gcacgtcctg accaacgacc gcgtcttcga caagggcggc
    12421 gtcttctacg accgcgcccg ggacatcgcc ggcaacggcc tggtcacctg cccgttcgcc
    12481 gaccaccgcc gccagcgccg gctgatgcag tcggcgttca cccgcggccg gctcaagcgg
    12541 tacgccgagg ccatgcgcgc cgagatcgag gacacggtgt cgcgctggca ggacggcatg
    12601 gtcgtcgacg ccttcccgga gatgtacggc atggccctgc gcacggtcgc ccgcaccctg
    12661 tactcgacac ccgtcagccc cgggctggcg gcgaaggtgg aacgttcctt cgacgtcgtg
    12721 ctcaacggcc tgttccggca gatgttcctg ccggccgcga tccgccggct gcccctgccg
    12781 tcccagcgcc ggtaccgcag caacctggac ttcctgcacg acaccaccca gcggctcatc
    12841 gaggactacc gcggctccga caccgagcac gacgacctgc tcgcggccct gctcgcctcc
    12901 cgcgacgacg acggcggacg gctcggcgac accgagatcc acgaccaggt catcaccgtc
    12961 atggcggccg gcaccgagac cgtcgccggc accctcacct gggtcttcta cctcctctcc
    13021 cagcacccgg agatcgaggc cgccctctac gacgagatcg acaccgtcct cggcggccgc
    13081 gccccggact gggacgacct gccgaacctg tccctggccg accggatcat ctccgagacg
    13141 ctccgactgc acccgccggc ctggctgttc acccgcctca ccacgtcccc gaccgaactc
    13201 gcgggccgcc ggctgccctc cggcaccacc gtcgtcttca gcccggccgc ggtcgcccgg
    13261 tacgaggaag ccttcgacga cccggcgagg ttcgaccccg accgctggct cccggaccgt
    13321 gtcgcgccgg ccgcccgcca cgcctacgtg ccgttcggca ccggcgcccg caagtgcatc
    13381 ggcgacctct acgcgcgcac cgaggccacc ctggggctcg ccaccatcct cggccgctgg
    13441 cgggtcggct gcgaacccgg catggacatc cgcccggtcc cgctggccac cgtctaccac
    13501 ccgcgccggc tgcgcctgcg gctggacgcg cgcaccccgc gccgcatgac ctccgccgtc
    13561 cccgcaccgg ccggaggtga cgcggcgtga gcacacacgg ctagtcgccg tccccgcagg
    13621 tctgcggggc gccggcgccc gcagaaccga acaagctgcg ggagtgaggc ggcggcggcc
    13681 gggcatgtgc ttgtccgggc cggatctcag cccgcagcac ctacccagtg gtcccaagga
    13741 gatacggcat gatcctcgac ggcataccgg ccgcccccgc ccagcacacc agacccgacc
    13801 cggccgcccg caagcagcgg ctgcgccgcc gcctggagcg gctgatcggc gtggccgcta
    13861 ccgaggggaa cgacctcgtg cccctgcgca acggcgacgc gatcttcccc gcgatgctcg
    13921 gggcgatccg ctcggccgag cgcacgatcg acatgatgac gttcgtgtac tggcgcggcc
    13981 agatcgcccg tgacttcgcc ggcgccctgg cggaccgcgc ccgtgccggg gtacgggtgc
    14041 ggctgctgct cgacggtttc ggcgccaagg agatcgaagg ggacctgctg gagctcatgg
    14101 acgaggccgg cgtgcaggtg gcctggttcc gcaagcccgt ctggctgtcg ccgttcaagc
    14161 agaaccaccg ctgtcaccgc aaggccctca tcatcgacga gcacaccgcg ttcacgggcg
    14221 gcgtcggcat cgccgaggag tggtgcggcg acgcccgcaa ccccggcgag tggcgcgaca
    14281 cccacgtgca ggtgcgcggc ccggccgtgg acggtgtcgc ggccgcgttc gcccagaact
    14341 gggccgagtg ccacgacgag ctcttcgacg accgcgaccg cttcaccgag cacgcgcagg
    14401 agggctcgtc ggtggtgcag gtcgtgcggg gctcggccag catcggctgg caggacatgc
    14461 agaccctgat ccgggtcatg ctcacgtccg ccgaggagcg gttccggctc gccaccgcct
    14521 acttcgcccc cgacacctac ttcatcgacc tgctctgcga gaccgcccgg cgcggggtgc
    14581 gcgtggagat cctgctgccc ggtccgcaca ccgaccagcg ggcctgccag ctcgccggcc
    14641 agcaccacta cgcacgcctg ctggaggcgg gggtgcacat ccggcagtac cagccgacca
    14701 tgatgcacgc caagatcatc acggtcgact cggtcgccgc cctcatcgga tccacgaact
    14761 tcaaccgccg gtccatggac cacgacgaag aggtcatgct cgccgtcctg gacgagacgt
    14821 tcaccgcgtc gctcgaccgc gacttcgatg aggacctgcg ccgcagcgtg gagatcgatc
    14881 cgacccgctg gcgccggcgt ccggtgctcc agcggctccg ggaagcggcc gtgatgccga
    14941 tccggcgctt cctgtgaggt gactgttccg cctgtgtgag gcagcatgtc gcccggccgg
    15001 gtgtgcttgc ccggccgctg ttcgggtacc gcgattgaat aagggtggta accgtaccga
    15061 cagatggttg aaagcgatgc gttcgtgact ggtctgagcg gctccgggaa cgaccgggtg
    15121 agccggccgg acgacgacct cctgtctctc gcgtcgacga tcgccgaagc cgtggaaggt
    15181 ctggcccacc tgtggtcggt cgccgcgcag ggggcgagtc tgcagttgtc gccgcaccag
    15241 ttgcgggccc tgcggatcct ggaggcggag ccgggactca atctcaccgg tctggccgtg
    15301 ggcatggaca tcgggctgcc gaccgccagc cggctctgtg accgcctgga ggcggccggc
    15361 ctcctggacc gtgtgctgca cccgcacaaa cggcgtgagg tgcagctgca cctcacgggc
    15421 cagggcagac aggtgctggc cgaggtcgcc tcgcgcaggt cgcaggcgct ggcccgcgtg
    15481 ctcgcggcca tggagtcggc cgagcgggag gcactgcggc gcgggctcca gggtttccgg
    15541 tccgctcagg acgacggccc gcggggcggg ggcggcgccg ggtcctgacg gcggccgtca
    15601 gcgcggtcgg ccgtgccagt cgaggcagac cacggccgcg tcggacatga gttcgctgct
    15661 gccgtggtgc tcgatcaggc cggagacgac cgcgcgtgcc gcctcgtgcg gcggcgcggg
    15721 gcgcgtggcg ctgaggatct gcctcagggc gccttcgccg aagagctcgc cctgcgcgga
    15781 gcgggtctcg tgcacgccgg tgctgaccac gatgagccgg tccccgggtg cgacccggaa
    15841 ggtctgctcc gtgtactcgc tctcctcgaa catgccgagc gggaactgtg cttccaggtc
    15901 gatgcgttcg gtgtggccgt cgcgctggcg gaacagctgg ggagaaccgg cgtccacggc
    15961 ggtcaccgtg ccggtggcca ggtcgaaccg cagcagcagg gtggaggcgt acgccttgcc
    16021 gccgtactgg gcgtggacgg cctggtcggc caggcaggcc tggtcggcga gggtgaggcc
    16081 ggcccgccgg gcgttgcgca gggcacccac cgcgaggctg gtcagcaggg ccgcgtcgat
    16141 gcccttgccc atgccgtcgg tgacggtgag ggtgaggtgg tcggcgtcgg ccgaccagtc
    16201 gaagttgtcg ccgccgatgg cgtaggccgg ctccagatgg gcgccgatga cgtactcctc
    16261 gcgggcggag ccgcgggcgg gcaggagctg ccactgcatc tcggcggcca gggtgaggcg
    16321 gcgggtgcgg cgggcctgga ggtacaggtc cgtgtcgcgg tcggcggtgg agacctcgtg
    16381 gccgagtgcc gtggcgaact cgccgagctg caggacggtg tccgggtcgg cggcccccgc
    16441 cggcaggcgg acgcagagga cgcccaggcg gtctccgcgc acggcgatgg ggaggtgcac
    16501 caggtggccg gccggctcgc ggaggatctc gaccaccggg cgctgctgga cgaaggcgct
    16561 gcccgccggg ccctcgtggg cggggaccgg ctcaccggtg tgcggcaggt gggacaccgg
    16621 ttgcaggacg gtcagtccgt agtcggcgag gaggagggtc acctccaggg ctccgacccg
    16681 ctcggcgagc agccggcggg ccgtggcgac cagggcatgg ggcggagccg cgcgcagctg
    16741 ggcttccgcg gaaggcagcg gttcggaggc gttcacggca tcggccctct cggcttgtgg
    16801 cgtccacgct accgcgatcg gcatcgcggc ggatcgcagg cggcggccgg ccgggcggtc
    16861 gcgtctcacg gcgtgccggt gcggggcgac ggcaggccgg cggcccagtc ggtgatggtc
    16921 acggtggtgc ctcgtccggg gcggctgtcg aggctgaact cctgcacgag ccgcctggcg
    16981 ccgctcaggc cgaggccgag gccgccggcg gaggtgtagc cgtcggtcaa ggccagttcc
    17041 acgtcgcgga tgccggggcc ggtgtcgacg aaggacagcc gcagcccgcg gcgggcaccg
    17101 tccgtgagcc gtgtcagttc cacgtgtccc ccaccaccgt gcaccagggc gttccgggcc
    17161 agttcgctgg ccgcggtgat cagcttggtc tgctggacga ggccgaaccc gacgccggcg
    17221 gcggcctggc gcacgcgtcg gcgcacccgt gccagatccg cgtccgagcc gatgggcagg
    17281 cgctcggagg gggaaccggt caccgcgcgc tcgccggcgc gctcgcgcgc ggcctgccgg
    17341 gccggcggcc ggtgctcgtc gggtggcggg ccaccggcgt ccgtcccgcg gcgtgggccg
    17401 tgccccgttc cgccaccttg cgtctccccc ctgctgcgag gcctcgcggc gccccgggcg
    17461 gtgatcccac cccgacaatg attgccgcat gacaaatgtt atcgggaaga ggccggcgtc
    17521 aacaacgcgc ggggccccac ggccggacgt cacgcccggc cgggccgccc gcgccagtcc
    17581 aggcacacca ccagggcgtc gtcctccgcc acggcggcct cgccacggtg gcccgtcagc
    17641 tcccgcagca gcgcgcgggg cacctcggcg gcgggcagca gccgagtgga ctggatggcc
    17701 cgggtcaggg cctgctcccc gtacggctcg cccttggggg aagccacctc gtggacgccg
    17761 tcgctgacga agaggagccg gtcaccgggc tggacctgga actcctgggc cacgtagtcc
    17821 gtctcctcga acatgcccag gggaagctgg gcgtcgaagt cgacgcgctc cacctcgccg
    17881 ccgcgcaggc gcagcagctg gggcgagccc gcgtccacga cgctggcccg gccggtggtc
    17941 agatcgaagt cgaacatgag gaccgacagg tagcagcggc cgcggtagtg ggcgtacacg
    18001 gcctggtcgg ccagggccgc ctggtcggcg atggagagcc cggcgcgccg ggcgttgcgc
    18061 agcgcgttga tggccaggtt cgtgagcagg gacgcctcta tgccctcacc catgccgttc
    18121 gtgacgtaca gcatcaggtg gtcggccttg accgaccagt cgaagttgtc gccgtagatg
    18181 gcgtacgccg gttccagttg ggccccgagg tcgtactcgg gccgggaaca ggagcggccg
    18241 ggcagcagct gccactgcat ctcggcggcg agggtgagcc ggtccctgcg ccgcgcctgc
    18301 aggtacaggt cggtgtcccg ctcggccacg agcacctcgc ggcccagcac gtcggcgagt
    18361 tcggccagtt cggcctcgca cgcgcgcgcc gtgtcgccgc tgggcagcgt cacggacagc
    18421 acgccgagcc ggtcaccgcg cacactgacc ggcaggtgca ggcgggcccg cccgtcacgc
    18481 cgttcctcgc agtagggctc ctgcgcgccg aaggcccggc cggccgggcc ggcgtgcacc
    18541 ggcaggggct ccggggtgcg cagcgggacc ccggacacgg cctggaggac cgtcaggccg
    18601 tagtcggcca tgaagaggtc cacgtccagc gcctgatatc gctccgtcag cacgacgcgg
    18661 accgcgtcga gcaattcgtc gggagccgct gtacgcaggg cgcgtgcagc ggcttcgaat
    18721 ctgttcacga tgggaataca accaatcttc gtctccggac aacggacagg cctcgctcgg
    18781 gagaccgggc accgtgaaga gcctcgccgg gcagccgggc tcgttcccgg ccggcacgga
    18841 ggcctagtac gctgacagac gccccagtgc ctgcgagagt gtgaccgtga ctgccttccg
    18901 ccgcccagag cccgatgagg tcgcacgtgt gaccacgacg gccgtcgagc tgctggaggt
    18961 cgtgtggggc cgggcctcca ccgcgcccac ctccgcgtcc cagctccggg tgctgcacat
    19021 cctcgagcac cacgacggca tcaacctgcg caccctggcc gagtccctcg cgtccacccc
    19081 gccgtccacc agccggctgt gcgaccggct gcaggccgcg gggttcgtcg agcgggtggt
    19141 gggcgcggag gaccggcgtg aggtacggct gcacctgagc ggccggggcc gctccttcct
    19201 cgccgatctg cgtgcccgca gggagcggga gttgcgcaag gtgctggcgg acatgcccgc
    19261 cggcaagcgc gtcgcgctgc tggaggggct ggaggcgttc tgcgccaccg cggccacgca
    19321 gatacacggc accgcggata ccgacagccg aagcgcctga aagacccttc acggcaccgg
    19381 cgccaccacc gccttccgcc gatggcggcc gacgcacggc gtggtctccg tcctccggag
    19441 cattccgagt ccttccccgc gtacgtccga cacggttact ctgttgcctc atgaccattg
    19501 ttgtcaaacg acaactgtgc ttcacagtgc tgtgagtcat cggatacccc gtatgcgcgt
    19561 cctacgccgg aacggtgcgg aatgtctcct gaggccaggg gctcagggct gatccggaac
    19621 ggcccgacgg tgctccggat tgcgtcgtag cagggagaag ttcagagcgg tggcgaacag
    19681 acaccacgcc gcgtacggcg ccagcgccgc ggcggccggg cggtcggtgc cggccgtccg
    19741 gcggatgagg cgggcgttgg cggcgtccag caggaccgtg ccggccaggc cgccccacag
    19801 gcttttgcgg cggaagaacg cgtggctcca ggcggcgttc agcgtcaggt cggccgccag
    19861 ggaggcggcc agccgcgcgc gttcgcggcc gcgggcccgg ctgagccccc ggccggcgga
    19921 ccaggcgatc gtggcgtaca gcggggtcca ggccgctccg aaggcccagg agggcggctg
    19981 ccacgacggc ttgtccaggg agcggtacca ggcgctgtcg gcgtcgaccg cccgggcgcc
    20041 ggccaccgct gtcgcggtga cggcggcggc cgcggcggct gtccaggccc cgcttctgat
    20101 cggtcgcgct tgctcgctga tggtcgtcac ggctctcctt gtaccccgag aaatttggtt
    20161 gtcgcccgtc cgccccggcg gccgggcgac ggccaccgcc acctcacgga ccggcccggg
    20221 agcggctggc cctttggaac tccgtggtgt gaggatggcg ccatgcacgc gacccctggg
    20281 atgaagatgc acgtcacacg ccacgagcag accttcgtgc tcacggtccg aggcgaagtg
    20341 gactacgacg acgcggagga cttcgacgcc gcatgggagg cggccgacaa ggccgcgctg
    20401 cccgtcacgg cggtggacct ctcccaggtc accttcgccg acagcatgct cctcaacgcc
    20461 ctcctgcagg cccggatccg ccaccaggcc gccggccggg acctcgtgct gctcggccct
    20521 ctgcggccgg cgatccaccg cctgttggcc atcagcggca ccatccagct gttcaccatc
    20581 agtgacgtcg gcgtcggcga cgccggtccc ggccccggcg gtgacggcgc gaacgacgca
    20641 ccatgaagcg gagtacagcg ggtaggcgaa ctcagcacac gagaacaccg agtgagcaag
    20701 aacaccgacc catcacgcac ggagacactt ccatggtcat cccgcttggg cagcaggcag
    20761 tggatgaacg acaccggacg gcacccctgc ggtacagcgc ggcctgggac acggccggcg
    20821 cgtccgtccc cgacgcccgg caggcggtac gcacgctgct ggcccgggca ggacaccggc
    20881 cggaccggcg accgagccag gacgcccagc tcgtcgtcag cgaactcgtc accaacgccc
    20941 tgcgccacgc gcccggcccc ggcgcactcc tgctggaact ggcgtccgac gccacctccc
    21001 tgctgatcgc cgtccgcgac agctcccggc gtccgcccga ggtccaggcg cgcgacgggg
    21061 gacgtgtcgg ggggcacggc ctgcacctgg tcagccggct gtgcgagcag atgcacaccg
    21121 tcctgctgga gaccggcaaa caggtgatgg tccggctcag cctggaaccg ggcgccgagt
    21181 agcggaccgc tccgggaggg cgtcacttct cgtagttgtg cagggccagt cccagcccga
    21241 agaaggtcgg cgcccattcg ccgacgaaga tgccccagcg gtccgcgcgc tcctcgccct
    21301 tcttctccac gctcaatgag acgcaccacg agatgacgga caggccgatg gaggcgaagg
    21361 cggcggcgta ggcgtgttcg gagcggatgc cggactcgtg cagcttcttg acgatcacgt
    21421 cggactcatt tccctgggaa acgggtggtg tgatccatcc catcggcagt gacggcggcg
    21481 cgcgaccgca cggggccgag cgggcgatgg ccacccggtg ccccgcgcgg gggaggtcac
    21541 gtggcgcccg ctccgctgac gccgtcctcc tcgagctccg ctccggcccg ctcgtccgcc
    21601 gccggggcgg tgagatggtc caggacgttc gtcatcagga gcatgcgctc caggacggcc
    21661 ggccggttgt ccaggtggag cgtcgcgccg agggtgctgg tacggcggtg gatcatgagc
    21721 agggtggaca ggcccgtgga gtcgatccac gtcagctcgc cgaagtccag gcggacgtcg
    21781 cgcggcgccc gtccggccga cagctgctcg aggaccgcgt ccagcgcgtc gtcgctcgtg
    21841 tcgtagtcga ggtctccgcg cacccgcacg gtcagcgtgc cgggctcacg gacgaagtcg
    21901 agggtgaact cagggggtgg caaggtggtc atgcgtgtgt ggaggggccg gggacaggac
    21961 ggacggagtg ctcggccagt acggcggtgc cctcacggat cagttcgacg gtacggggga
    22021 agtcgcggag ctggccggcc agagcgtcca ggcccgcggt gagcgagtgg gcggggacct
    22081 gccgggcctc caggatgtct gcggtccagg tcaggaacgc ggtgaacagg tcggtgtcgt
    22141 cgacgtagag cgccg
//
