LOCUS NZ_KQ948851 12118 bp DNA linear CON 21-APR-2024 DEFINITION Streptomyces bungoensis strain DSM 41781 PRJNA299233_s001, whole genome shotgun sequence. ACCESSION NZ_KQ948851 VERSION NZ_KQ948851.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces bungoensis ORGANISM Streptomyces bungoensis Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 1011152) AUTHORS Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S. TITLE Draft genome sequence of Streptomyces bungoensis DSM 41781, type strain for the species Streptomyces bungoensis JOURNAL Unpublished REFERENCE 2 (bases 1 to 1011152) AUTHORS Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S. TITLE Direct Submission JOURNAL Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1, Bielefeld 33615, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Date :: 13-OCT-2014 Assembly Method :: Newbler v. 2.8 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 60.6x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_001514215.1-RS_2024_04_21 Annotation Date :: 04/21/2024 02:15:15 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 7,539 CDSs (total) :: 7,454 Genes (coding) :: 7,226 CDSs (with protein) :: 7,226 Genes (RNA) :: 85 rRNAs :: 1, 1 (5S, 16S) complete rRNAs :: 1, 1 (5S, 16S) tRNAs :: 80 ncRNAs :: 3 Pseudo Genes (total) :: 237 CDSs (without protein) :: 228 Pseudo Genes (ambiguous residues) :: 0 of 237 Pseudo Genes (frameshifted) :: 67 of 237 Pseudo Genes (incomplete) :: 196 of 237 Pseudo Genes (internal stop) :: 10 of 237 Pseudo Genes (multiple problems) :: 43 of 237 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 00:26:42 NOTE :: This is a single region extracted from a larger record! Orig. start :: 95221 Orig. end :: 107339 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to KQ948851.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..12118 /candidate_cluster_numbers="1" /contig_edge="False" /product="RiPP-like" /region_number="1" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..12118 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="1" /tool="antismash" protocluster 1..12118 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[5000:7118](+)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" /tool="antismash" proto_core 5001..7118 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" gene 729..2201 /locus_tag="AQJ66_RS00330" /old_locus_tag="AQJ66_00330" CDS 729..2201 /GO_function="GO:0008173 - RNA methyltransferase activity [Evidence IEA]" /GO_process="GO:0042245 - RNA repair [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125168.1" /locus_tag="AQJ66_RS00330" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00330" /product="3' terminal RNA ribose 2'-O-methyltransferase Hen1" /protein_id="WP_061914577.1" /transl_table=11 /translation="MFLTISTRGTAALPATDLGYLLHKHPGKAQKFSTSYGTAHVFYPE ADAERCTAALLLEVDPLALVRRGKGKGRGGAPDAALAQYVNDRPYAASSLLAVALSAVF SSALRGVCAARPERAAAPLPLRVEVPALPARGGPDLVRGLFGPLGWDVTAEPVALDGEF PEWGDSRYVRLVLESEALTLAEALRHLYVLLPVLDDAKHYWVSSDEVDKLLRAGDGWLA GHPEQQLITSRYLSRRWSLTRAATERLELARLAEADDSQVEAIDNAVEPETGTEEKPTP LAVRRRDAIIEALRACGAARVLDLGCGQGRLVQELLKDARFTEVAGVDVSVRALTIAAR RLKLDRMGERQASRVQLFQGSLAYTDKRLKGYDAAVLSEVIEHLDLPRLPALEYAVFGH ARPRTVLVTTPNVEYNVRWESLPAGHVRHGDHRFEWTREQFRTWAGAVAERHGYGVGFR PVGPDDPEVGPPTQMAVFTLHTHANEKEAKAA" gene 2198..4744 /locus_tag="AQJ66_RS00335" /old_locus_tag="AQJ66_00335" CDS 2198..4744 /GO_function="GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IEA]" /GO_function="GO:0051731 - polynucleotide 5'-hydroxyl-kinase activity [Evidence IEA]" /GO_process="GO:0042245 - RNA repair [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020122488.1" /locus_tag="AQJ66_RS00335" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00335" /product="polynucleotide kinase-phosphatase" /protein_id="WP_061914580.1" /transl_table=11 /translation="MTDTARTGGRILPVTDLSLVVLVGASGSGKSTFARRHFKPTEVIS SDFCRGLVSDDENDQSATGDAFDVLHYIAGKRLAAGRRTVVDATSVQQDARRQLIDLAK RYDVLPIAIVLDVPEEVCAERNAARTDRADMPRRVIQRHIRELRRSLRHLEREGFRKVH VLRGAEEAENATVVTEKRFNDLTHLTGPFDIVGDVHGCSAELESLLGKLGYTDGVHPEG RTAVFVGDLVDRGPDSPGVLRRVMSMVKSGNALCVPGNHENKYGRHLKGRGVRHTHGLA ETIAQMAGESEEFKAEVRQFIDGLVSHYVLDGGRLVVCHAGLPERYHGRTSGRVRSHAL YGDTTGETDEFGLPVRYPWAEDYRGRAAVVYGHTPVPEATWLNNTICLDTGAVFGGKLT ALRWPERELVDVPAERVWYEPAKPLRTEAPGGQDGRPLDLGDVHGRRVVETRHAGRVSV REENAAAALEVMSRFAVDPRLLPYLPPTMAPTPTSRVDGYLEHPVEAFAQYAADGVAQV VCEEKHMGSRAVALVCRDAEAARGRFGVDGPTGSLYTRTGRPFFDDGEVTEEILGRLRA AIGAAGLWEELATDWLLLDAELMPWSLKASGLLRTQYAAVGAASGAVLPAALAALESAA ARGTDLGGLLERQRERAADAAQFTAAYRRYCWSTEGLEGVRLAPFQILAARGRSLAALP HDEQLALLDRLVEHDGTGLLRTTRRLRVDTTDPESVRAGVDWWLEMTGRGGEGMVVKPL GALARTEQGRLVQPGVKCRGREYLRIVYGPEYTRPDNLAQLRRRFLNHKRSLALREYAL GLEALDRLADGEPLWRVHEAVFGVLALESEPVDPRL" gene 4855..4998 /locus_tag="AQJ66_RS38710" CDS 4855..4998 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="AQJ66_RS38710" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="hypothetical protein" /protein_id="WP_159052513.1" /transl_table=11 /translation="MDDAQDVQDAQPQGAVTVVGMEIRKTVVREDRGTTRRPAILEKRP TC" gene 5001..7118 /locus_tag="AQJ66_RS00340" /old_locus_tag="AQJ66_00340" CDS 5001..7118 /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: TIGR03975" /gene_functions="biosynthetic-additional (rule-based-clusters) PF04055" /gene_functions="other (smcogs) SMCOG1277: Radical SAM domain protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014675582.1" /locus_tag="AQJ66_RS00340" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00340" /product="RiPP maturation radical SAM C-methyltransferase" /protein_id="WP_167359134.1" /sec_met_domain="TIGR03975 (E-value: 7.1e-166, bitscore: 548.8, seeds: 14, tool: rule-based-clusters)" /sec_met_domain="PF04055 (E-value: 8.7e-12, bitscore: 41.5, seeds: 518, tool: rule-based-clusters)" /transl_table=11 /translation="MRLHLVTMPWQPLDLPSLQLGLLNRLVRRTRPGTEVTEFHGSLRW AEFLLEHSAGALRPGDYVEVGSDAIFHGLGDWVFSGVLYDDPGWGLDRLRAYAADRDVP VATALAMRPHAAAFTAACAAEILAAEPDVVGFTTTFMQNVSSLALARELKSRRPGLTVV LGGSNCDGPMGHALHRNHPFVDHVVRGEAEYAFPALLRHLEAGTAPVDVPGLCWWDGPV PRANTETRRTVAPADIPSPDYDQWQEALDASPVREFVHPKLVVEGARGCWWGEKHHCTF CGLNGSAMAFRAKPGERLWAEVDRLVRRHRLLDVVTVDNILDMAHFRDFLPRAAASGWD LRLHYEVKSNLTPDQLRLLADSGTVHIQPGIESLGSRVLDLMDKGVTAARNVRTLRECE NHALTCSWNLLYGFPGETAEDYAPVVGQLAALVHLQPPSGAHRIQLERFSPHFTDLELG FRKRRPARMYSHVYDLPESELADLVYLFDTDDAGIGGAAEQRLGEAVAAWRAGHAQSRL LFEEDGADLLVHDRRHGWPAATHRFTGWRAAALRRLEDGRTVAALHRLLAADGHPVPAD SLAEWVRHALALGLLFRDGGTYVALPTWGEPDRLPDGADGVLYHRRGPGFVTVMDRREP GTAVRLTLDHPALVAAFDLLAEPTPLDTLDPVQREAVRLLTAERLVRVEAGRAVALPPR IRRWPVPCTAI" gene complement(7146..7397) /locus_tag="AQJ66_RS00345" /old_locus_tag="AQJ66_00345" CDS complement(7146..7397) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014677115.1" /locus_tag="AQJ66_RS00345" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00345" /product="DUF5133 domain-containing protein" /protein_id="WP_061914583.1" /transl_table=11 /translation="MLLPAEKELRAVLARFADARFRHDLQPTGHSSRELEDTSYTLCVM TGTQTVDEALAAADALLERMTADRRAVTTTRATQTLAA" gene complement(7547..8446) /locus_tag="AQJ66_RS00350" /old_locus_tag="AQJ66_00350" CDS complement(7547..8446) /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014044102.1" /locus_tag="AQJ66_RS00350" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00350" /product="NAD-dependent protein deacetylase" /protein_id="WP_061914586.1" /transl_table=11 /translation="MRMRPTLTWTPTEDLPPGTTDLRPVADALGGGGVLVLSGAGISTE SGIPDYRGEGGSLSRHTPMTYQDFTAGAQARRRYWARSHLGWRTFGRARPNPGHRAVAA FERHGLLSGVITQNVDGLHQAAGSDGVVELHGSLDRVVCLSCGDVSPRRELARRLEEAN PGFDPVAAGINPDGDADLTDDQVGDFRVVPCALCGGILKPDVVFFGEAVPPQRVEHCRA LVREAASLLVLGSSLTVMSGLRFVRQAAEAGKPVLIVNRDPTRGDRHALTRVALPLGAA LTAVAGRLGVSLDGGSAV" misc_feature complement(8436..8449) /note="TFBS match to ArgR, Regulator of arginine biosynthesis genes, confidence: weak, score: 16.85" /tool="antismash" misc_feature complement(8459..8473) /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 19.12" /tool="antismash" misc_feature complement(8460..8473) /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: weak, score: 17.24" /tool="antismash" gene complement(8522..8860) /locus_tag="AQJ66_RS00355" /old_locus_tag="AQJ66_00355" CDS complement(8522..8860) /GO_function="GO:0043856 - anti-sigma factor antagonist activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003981380.1" /locus_tag="AQJ66_RS00355" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00355" /product="STAS domain-containing protein" /protein_id="WP_061914589.1" /transl_table=11 /translation="MSPLAITTRDATTGPVLEIIGELDYANADELRERLTTLDLRPGQR LVIDLSGMEFCDSSGLTALINARNHAHAAQADIALAAVPAHTLRVLRIVGLDQIFAVYP DRDSAIGS" gene complement(8857..10185) /locus_tag="AQJ66_RS00360" /old_locus_tag="AQJ66_00360" CDS complement(8857..10185) /GO_function="GO:0016791 - phosphatase activity [Evidence IEA]" /codon_start=1 /gene_functions="other (smcogs) SMCOG1054: hypothetical protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020120230.1" /locus_tag="AQJ66_RS00360" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00360" /product="SpoIIE family protein phosphatase" /protein_id="WP_107118822.1" /transl_table=11 /translation="MMCPADQQPDPQDPDTGAGADAGAGRLADTASFAALLEDSAEDLY ESAPCGYLSTLMDGTVAKINTTLLDWLGLEREAVVGRMRFTDLLTVGGRLYHETHFAPL LRMQGELSGIALDVRRADGGRMPVLVSSAVKHGSTGEPLLIRTTLFDARERRAYEEELL RGRKAAEEARRQAEADRTRLQEALAVLQQSLLPDSLPAVPGVETAAHYHTASPDRLGGD FYDVFPVDGTRFAFFLGDVCGKGPQAAALTSLTRYTLRAAALHDPGPVAALTTLNKVLY ERYSGSGDPRYCTAVYGTLEPDPATGRVAVHLAAGGHPPALVLRADGTAGYLPTPGGLL VGVVPGAHFTTASATLGPGDTLLLYTDGLTEARTGDDRTGLYGDEALLAFATGLAGRSP QAVVGALTGLLASFGDGLDDDTALLALGAPAHPAARPPRRGPA" gene complement(10182..10985) /locus_tag="AQJ66_RS00365" /old_locus_tag="AQJ66_00365" CDS complement(10182..10985) /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (17-251). E-value: 6.3e-26. Score: 83.4. Matches aSDomain: nrpspksdomains_AQJ66_RS00365_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036: alpha/beta hydrolase fold protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020130118.1" /locus_tag="AQJ66_RS00365" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="AQJ66_00365" /product="alpha/beta hydrolase" /protein_id="WP_061914595.1" /sec_met_domain="PF00561 (E-value: 8.5e-23, bitscore: 77.0, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 9.2e-24, bitscore: 81.0, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MDVTRRNNVTVTGDPQGPAVVLAHGFGCDQNMWRATVPALARDHR VVLFDYVGSGRSDPSAFSEKRYASLDGYARDAVEVCEALDLRDAVFVGHSVSAMIGVLA ARTAPERIGALVMVAPSPRYLDDDGYRGGFSAADIDELLASLESNYLGWSAAMAPVIMG NPDRPELGDELRNSFCATDPDMARVFARTTFLSDSRDDLKSVRVPTLVLECTQDVIAPR EVGAFVHAAIPGSTLVTLDATGHCPHLSAPEATNEAITTFLAGLR" aSDomain complement(10233..10934) /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_AQJ66_RS00365_Abhydrolase_1.1" /evalue="6.30E-26" /label="AQJ66_RS00365_Abhydrolase_1.1" /locus_tag="AQJ66_RS00365" /protein_end="251" /protein_start="17" /score="83.4" /tool="antismash" /translation="PAVVLAHGFGCDQNMWRATVPALARDHRVVLFDYVGSGRSDPSAF SEKRYASLDGYARDAVEVCEALDLRDAVFVGHSVSAMIGVLAARTAPERIGALVMVAPS PRYLDDDGYRGGFSAADIDELLASLESNYLGWSAAMAPVIMGNPDRPELGDELRNSFCA TDPDMARVFARTTFLSDSRDDLKSVRVPTLVLECTQDVIAPREVGAFVHAAIPGSTLVT LDATGHCPHLSA" misc_feature complement(11441..11450) /note="TFBS match to AbrC3, Antibiotic production activator, confidence: strong, score: 18.16" /tool="antismash" misc_feature 11723..11737 /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 19.19" /tool="antismash" ORIGIN 1 tcgaactcgg cctcggcgcg ggctggttcg aggacgagca caaggcgtac ggcatcccgt 61 tcccccagga gaagttcggg cgcctggagg agcagctcga gatcgtcacc ggtctgtggt 121 cgaccaagct cggcgagacc ttcgacttcc acggcacgta ctacgacctg accggctcgc 181 ccgcgctccc caagcccgcc caggaccgcg tccccgtcct gatcggcggg cacggcgcga 241 ctcgcacccc gcgcctcgcg gcccggtacg ccgacgagtt caacatgccc ttcgcgtctg 301 tggaggacag cgagcggcag ttcggccgcg tccgtgccgc cgccgagcag gcgggccggg 361 gcgcggacgc cctgacgtac tccaacgcgc tcgtggtgtg cgtcggccgg gacgaccggg 421 aggtcgcccg gcgggccgcc gcgatcggcc gcgaggtgga cgagctgaag gccaacgggc 481 tggccggctc cccggccgag gtggtcgaca agatcggccg ctacgccgcg atcggctccc 541 gccgcctcta cctgcagatg ctcgacctgc acgacctgga ccacctggag ctcatctcct 601 ccgaggtcca gacccagctg cggtagcgcc cacgcgcgac gacggacccg cgcccccgtc 661 ccggggcgcg gggccgtgaa ccggaaaacg ggtggtcacc gggggtcgcg gccgacagac 721 tcggacacgt gttcctgacg atctccacac gcggcaccgc cgccctcccg gccaccgacc 781 tcgggtacct gctgcacaag catcccggca aggcgcagaa gttctcgacg tcctacggca 841 ccgcccacgt cttctacccg gaggcggacg ccgagcgctg cacggcggcg ctgctgctgg 901 aggtcgatcc gctggcgctg gtgcgccggg gcaagggcaa gggccgcggc ggagcacccg 961 acgcggcact cgcgcagtac gtcaacgacc ggccctacgc ggcctcctcg ctgctcgcgg 1021 tcgcgctgag cgccgtgttc tccagcgcgc tgcggggtgt gtgcgccgcg cgcccggaac 1081 gggccgccgc gcccctgccg ttgcgcgtcg aggtgcccgc gctgcccgcc cggggcggcc 1141 cggacctcgt acggggcctc ttcgggccgc tcggctggga cgtgaccgcc gaaccggtcg 1201 ccctcgacgg cgagttcccc gagtggggcg actcccgcta cgtacggctc gtcctggagt 1261 cggaggcgct gaccctcgcc gaggcgctgc gccacctgta cgtgctgctg cccgtcctcg 1321 acgacgccaa gcactactgg gtctcctccg acgaggtcga caagctgctg cgggccggcg 1381 acggctggct ggccgggcac ccggagcagc agctcatcac cagccgctac ctctcccgcc 1441 gctggtcgct gacccgggcg gcgacggagc ggctggagct ggcgcgcctg gccgaggccg 1501 acgacagcca ggtcgaggcc atcgacaacg cggtcgagcc ggagaccggg accgaggaga 1561 agccgacgcc gctcgccgtg cggcgccggg acgcgatcat cgaggcgctg cgcgcctgcg 1621 gcgcggcccg cgtcctcgac ctcggctgcg ggcagggccg gctggtgcag gagctgctca 1681 aggacgcgcg gttcaccgag gtcgccggtg tcgacgtgtc cgtgcgggcc ctcaccatcg 1741 ccgcgcgcag gctgaagctg gaccgcatgg gggagcggca ggcgtcccgc gtgcagctct 1801 tccagggctc gctcgcctac accgacaagc ggctcaaggg ctacgacgcc gccgtgctca 1861 gcgaggtgat cgagcacctg gacctgcccc ggctgcccgc cctggagtac gccgtgttcg 1921 ggcacgcccg cccgcgcacg gtcctcgtga ccaccccgaa cgtcgagtac aacgtccgct 1981 gggagtccct accggccggg cacgtccggc acggcgacca ccgcttcgag tggacccgcg 2041 agcagttccg gacctgggcg ggcgccgtgg ccgaacgcca cggctacggc gtcggcttcc 2101 ggcccgtggg gccggacgac ccggaagtcg ggccgcccac gcagatggcc gtgttcaccc 2161 tgcacaccca cgcgaacgag aaggaggcga aggcggcatg accgacacag cacggaccgg 2221 gggacggatc ctccccgtca ccgacctctc cctcgtcgtc ctcgtcggcg cctccggctc 2281 cggcaagtcc accttcgccc gccgccactt caagcccacc gaggtgatct cctccgactt 2341 ctgccgcggc ctggtctcgg acgacgagaa cgaccagagc gccaccgggg acgccttcga 2401 cgtcctgcac tacatcgcgg gcaagcgcct cgcggccggc cgccgcacgg tcgtggacgc 2461 caccagcgtg cagcaggacg cccggcggca gctgatcgac ctggccaagc ggtacgacgt 2521 gctgcccatc gccatcgtgc tggacgtccc ggaggaggtg tgcgccgagc gcaacgcggc 2581 ccgcaccgac cgcgccgaca tgccgcgccg ggtgatccag cgccacatcc gcgaactgcg 2641 ccgctccctg cggcacctgg agcgcgaggg cttccgcaag gtgcacgtgc tgcgcggagc 2701 ggaggaggcc gagaacgcca ccgtcgtcac cgagaagcgg ttcaacgacc tgacccacct 2761 caccggcccc ttcgacatcg tcggcgacgt ccacggctgc tccgccgaac tggagtcgct 2821 gctcggcaag ctcgggtaca ccgacggcgt ccaccccgag ggccgcacgg ccgtcttcgt 2881 cggcgacctc gtcgaccgcg gccccgacag ccccggcgtg ctgcggcgcg tgatgtcgat 2941 ggtgaagtcg ggcaacgcgc tgtgcgtgcc cggcaaccac gagaacaagt acggccgtca 3001 cctcaagggc cggggcgtcc ggcacaccca cggcctcgcc gagaccatcg cgcagatggc 3061 gggcgagagc gaggagttca aggccgaggt ccggcagttc atcgacggcc tggtcagcca 3121 ctacgtcctc gacggcggcc ggctggtcgt ctgccacgcc ggcctgccgg agaggtacca 3181 cggccgcacc tcgggccggg tgcgctcgca cgccctgtac ggcgacacca ccggcgagac 3241 cgacgagttc gggctgccgg tgcgctaccc gtgggcggag gactaccgcg gccgggcggc 3301 ggtcgtctac ggccacaccc cggtgccgga ggccacctgg ctgaacaaca ccatctgcct 3361 ggacaccggc gcggtcttcg gcggcaagct caccgcgctg cgctggcccg agcgcgagct 3421 ggtcgacgta ccggccgagc gggtctggta cgagccggcg aagccgctgc gcaccgaggc 3481 gccgggcggt caggacggcc gcccgctgga cctcggcgac gtgcacggac gcagggtcgt 3541 cgagacccgg cacgcgggac gggtctcggt gcgcgaggag aacgcggcgg ccgccctgga 3601 ggtcatgagc cgcttcgccg tcgacccgcg cctgctgccg tacctgccgc cgaccatggc 3661 gccgacgccg acctcgcggg tcgacggcta cctggagcac ccggtggagg cgttcgcgca 3721 gtacgcggcc gacggggtgg cgcaggtggt gtgcgaggag aagcacatgg gctcgcgggc 3781 cgtggccctg gtgtgccggg acgcggaggc ggcgcgcggg aggttcggcg tggacggccc 3841 gaccgggtcg ctctacaccc gtaccggccg gccgttcttc gacgacggcg aggtgaccga 3901 ggagatcctc ggccggctgc gcgcggcgat cggggcggcc ggtctgtggg aggaactcgc 3961 caccgactgg ctgctgctgg acgccgagct gatgccgtgg tcgctgaagg cctcggggct 4021 gctgcgcacc cagtacgcgg ccgtgggcgc cgcgtccggc gcggtgctcc cggccgcgct 4081 cgccgcgctg gagtcggcgg cggcccgggg caccgacctg ggcggcctgc tggagcggca 4141 gcgcgagcgc gccgccgacg cggcccagtt caccgccgcc taccgccgct actgctggag 4201 caccgagggc ctggaagggg tccgccttgc ccccttccag atcctcgccg cgcggggccg 4261 cagcctcgcc gcgctgccgc acgacgagca gctggccctg ctcgaccggc tggtggagca 4321 cgacggcacc ggactgctgc ggacgacccg gcggctgcgc gtcgacacga ccgaccccga 4381 gtcggtccgc gccggcgtcg actggtggct ggagatgacc ggccggggcg gcgagggcat 4441 ggtcgtcaag ccgctcggcg cgctggcccg caccgagcag gggcggctgg tgcagcccgg 4501 ggtcaagtgc cggggccgcg agtacctgcg gatcgtctac ggccccgagt acacccgccc 4561 ggacaacctc gcccagctcc gccgccggtt cctgaaccac aagcggtcgc tggcgctgcg 4621 cgagtacgcc ctcggcctgg aggccctgga ccggctcgcg gacggggagc cgctgtggcg 4681 ggtccacgag gcggtgttcg gggtgctcgc cctggagtcg gagccggtcg accccaggtt 4741 gtagcccgcc ggcggccgct cttcacggaa cgcccttgtg ccgcacacgg atacgtccat 4801 agggtggacg gccgtgcggc acgggggtgt ccgcgcaccc ggggaggggg gaccgtggac 4861 gacgcgcagg acgtgcagga cgcgcagccg cagggggcgg tgacggtggt gggcatggag 4921 atcaggaaga ccgtggtccg cgaggaccgc ggcaccaccc gccggccggc gatcctggag 4981 aagcggccga cctgctgacc atgcgcctcc acctggtcac gatgccctgg cagccgctcg 5041 acctgccgtc cctgcaactg ggtctgctga accggctggt gcgccggacc cggcccggga 5101 ccgaggtgac cgagttccac ggctcgctgc gctgggcgga gttcctgctg gagcactccg 5161 cgggcgcgct ccggccgggc gactacgtgg aggtcggcag cgacgcgatc ttccacgggc 5221 tcggcgactg ggtcttctcc ggcgtcctgt acgacgaccc cggctggggc ctggaccggc 5281 tgcgcgccta cgcggccgac cgggacgtcc ccgtagccac cgccctcgcc atgcgccccc 5341 acgcggccgc gttcaccgcc gcctgcgccg ccgagatcct ggcggccgag ccggacgtcg 5401 tggggttcac caccacgttc atgcagaacg tctcctccct cgccctcgcc cgtgaactca 5461 agtcccgcag gcccgggctg acggtggtcc tcggcggcag caactgcgac gggccgatgg 5521 gccacgccct gcaccgcaac cacccctttg tcgaccacgt ggtgcgcggc gaggcggagt 5581 acgccttccc ggccctcctg cggcacctgg aggcggggac cgcgcccgtg gacgtgcccg 5641 gcctgtgctg gtgggacggg cccgtgccgc gggccaacac cgagacccgg cggaccgtgg 5701 cgcccgccga catcccctcg cccgactacg accagtggca ggaggccctg gacgcctccc 5761 cggtgcggga gttcgtccac cccaagctgg tcgtcgaggg cgcccggggc tgctggtggg 5821 gcgagaagca ccactgcacc ttctgcgggc tcaacggctc cgccatggcc ttccgggcca 5881 aaccggggga gcggctgtgg gcggaggtcg accggctggt ccgccggcac cggctgctcg 5941 acgtggtcac cgtcgacaac atcctcgaca tggcccactt ccgggacttc ctgccccgcg 6001 cggccgcgag cggctgggac ctgcggctgc actacgaggt caagtccaac ctcacccccg 6061 accagctcag gctcctcgcc gactccggca ccgtccacat ccagccgggc atcgagagcc 6121 tgggcagccg ggtcctggac ctcatggaca agggcgtcac cgcggcccgc aacgtccgga 6181 ccctgcgcga gtgcgagaac cacgcgctga cctgctcctg gaacctgctg tacggcttcc 6241 ccggcgagac ggcggaggac tacgcacccg tcgtcggcca gctggccgcc ctcgtccacc 6301 tccagccgcc gagcggcgcc caccgcatcc agctggagcg cttcagcccg cacttcaccg 6361 acctggagct gggcttccgg aagcgccggc cggcccggat gtacagccac gtctacgacc 6421 tgcccgagag cgaactcgcg gacctggtct acctgttcga caccgacgac gcggggatcg 6481 ggggagccgc ggagcagcgg ctgggggagg ccgtcgccgc ctggcgggcc gggcacgcgc 6541 agtcccggct gctgttcgag gaggacggcg cggacctgct ggtgcacgat cgccggcacg 6601 gctggccggc cgccacccac cggttcaccg gctggcgggc cgcggccctg cgccgcctgg 6661 aggacggccg cacggtggcc gccctgcacc ggctgctcgc cgccgacggc cacccggtcc 6721 cggcggactc actggccgag tgggtgcggc acgcgctggc gctggggctg ctgttccgcg 6781 acggcggcac ctacgtcgcc ctgcccacct ggggcgagcc ggaccggctg ccggacggcg 6841 ccgacggcgt cctctaccac cggcgcggtc ccggcttcgt caccgtcatg gaccgcaggg 6901 agcccggcac ggcggtccgg ctcaccctgg accatcccgc tctcgtcgcc gccttcgacc 6961 tgctcgccga gccgaccccg ctcgacacgc tggaccccgt ccagcgggag gccgtacggc 7021 tgctcacggc cgagcgcctg gtgcgggtgg aggccggccg ggcggtcgcc cttcccccgc 7081 gcatccggcg ctggccggtc ccctgcacgg cgatctgacc tgaacgtccc gggacgcggg 7141 ggcggtcagg cggccagggt ctgcgtcgcc ctggtggtgg tgaccgccct gcggtccgcc 7201 gtcatccgct ccagcagggc gtcggcggcg gccagggcct cgtccaccgt ctgggtgccg 7261 gtcatgacgc acagcgtgta ggaggtgtcc tcgagctctc ggctcgagtg gccggtgggc 7321 tgcaggtcgt ggcggaaacg ggcgtcggcg aagcgggcga gcaccgcacg cagttccttc 7381 tccgcaggca gcaacacagc gacaacctcc ctcgtcggac gggccgtcga cgcggcccgc 7441 acatcaacgc agcgcgcacc cacggggtgg cacgacagtc gacacggagc agatggatgc 7501 tccgtgcatc cgtgtgcccc gccaggctca cgtcatgcct ggcgtctcag acggctgacc 7561 caccgtcaag ggagacgccc agccggcccg ccacggcggt gagggccgcg ccgaggggga 7621 gcgcgacgcg ggtgagggcg tgccggtcgc cccgggtcgg gtcccggttg acgatcagca 7681 ccggcttgcc ggcctcggcc gcctggcgga cgaaccggag ccccgacatc accgtcagcg 7741 aggagcccag gaccagcagc gaggccgcct cgcggaccag cgcgcggcag tgctcgaccc 7801 gctgcggcgg aacggcctcg ccgaagaaca ccacgtccgg tttgaggatg ccgccgcaga 7861 gcgcgcaggg caccacgcgg aagtccccga cctggtcgtc ggtgaggtcg gcgtcgccgt 7921 ccgggttgat gccggcggcc accggatcga agcccgggtt ggcctcctcc agccgccggg 7981 cgagctcccg gcgcgggctg acgtcgccgc aggagaggca gacgacccgg tccaggctcc 8041 cgtggagttc cacgacgccg tcgctgccgg cggcctggtg caggccgtcg acgttctggg 8101 tgatcacacc cgagagcagg ccgtgccgct cgaacgcggc cacggcccgg tgcccggggt 8161 tggggcgggc ccggccgaag gtgcgccagc cgaggtggct gcgcgcccag taccggcgcc 8221 gggcctgggc accggcggtg aagtcctggt aggtcatcgg ggtgtgccgg ctcaggctgc 8281 cgccctcgcc ccggtagtcg gggatgcccg actccgtgga gatgcccgcc ccgctgagca 8341 ccagcacccc gccgccgccc agcgcgtcgg cgaccggccg caggtcggtg gtgccgggcg 8401 gcaggtcctc ggtgggcgtc caggtcaggg tggggcgcat gcgcatgccg ccagggtacg 8461 gaacgggtgt tccggccgcc ttgccgctcg cgctcatcgg ttcaccgccc cgggcaccgc 8521 ttcaggagcc gatcgcgctg tcccggtcgg gatagaccgc gaagatctgg tcgaggccga 8581 cgatgcgcag cacgcgcagg gtgtgggccg ggaccgcggc gagcgcgatg tcggcctggg 8641 cggcgtgtgc gtggttgcgg gcgttgatca gggcggtgag gccgctggag tcgcagaact 8701 ccatgccgga caggtcgatg acgaggcgct gccccggccg gaggtcgagt gtggtgagcc 8761 gctcgcgcaa ctcgtcggcg ttggcgtagt cgagttcgcc gatgatctcc aggacgggac 8821 cggtcgtggc gtctcgggtg gtgatcgcca gcgggctcat gcggggcctc tcctcggagg 8881 gcgggcggcg gggtgggcgg gggcaccgag ggcgagcagg gcggtgtcgt cgtcgaggcc 8941 gtcgccgaag gaggccagca ggccggtcag ggcccccacg acggcctgcg gggaccggcc 9001 cgccaggccg gtggcgaagg cgagcagggc ctcgtccccg tacaggcccg tacggtcgtc 9061 gccggtgcgg gcctcggtga gcccgtcggt gtagagcagc agggtgtcgc cggggccgag 9121 ggtggcgctg gcggtggtga agtgcgcgcc gggcacgacg ccgacgagga ggccgccggg 9181 ggtgggcagg tagccggccg tgccgtcggc gcgcaggacg agggccgggg ggtgcccgcc 9241 cgcggcgagg tggacggcga cccggccggt cgcggggtcg ggttcgagcg tgccgtagac 9301 ggcggtgcag tagcgcgggt cgccgctgcc cgagtagcgc tcgtagagca ccttgttcag 9361 ggtggtcagg gcggcgacgg ggccggggtc gtgcagggcg gcggcgcgca gggtgtagcg 9421 ggtcagcgag gtgagcgcgg cggcctgggg gcccttgccg cacacgtcgc cgaggaagaa 9481 ggcgaagcgt gtgccgtcga cggggaagac gtcgtagaag tcgccgccga gccggtcggg 9541 ggaggccgtg tggtagtggg cggccgtctc caccccgggg acggccggca ggctgtcggg 9601 cagcagcgac tgctggagta cggcgagggc ctcctgcagc cgggtgcggt cggcctccgc 9661 ctgccggcgc gcctcctcgg ccgccttgcg gccgcgcagg agctcctcct cgtaggcgcg 9721 gcgctcccgg gcgtcgaaga gggtggtgcg gatcagcagg ggttcgccgg tgctgccgtg 9781 cttgaccgcc gaggacacca gcaccggcat ccggccgccg tcggcccgcc tgacgtccag 9841 ggcgatcccg ctgagctcgc cctgcatccg cagcagcggc gcgaagtgcg tctcgtggta 9901 cagcctgccg cccacggtca gcaggtcggt gaagcgcatc cggccgacca ccgcctcgcg 9961 ttccaggccg agccagtcca gcagcgtggt gttgatcttc gcgacggtgc cgtccatcag 10021 cgtggacagg tacccgcacg gcgcggactc gtacaggtcc tcggcgctgt cctccagcag 10081 tgcggcgaac gacgccgtgt ccgcgagcct gccggccccg gcgtcggccc cggcgccggt 10141 gtcggggtcc tgcgggtccg gctgctggtc ggccgggcac atcatcgcag gcccgcgagg 10201 aaggtggtga tcgcctcgtt ggtggcctcg ggcgcggaca ggtgcgggca gtggccggtc 10261 gcgtcgaggg tgaccagggt cgagccgggt atcgccgcgt ggacgaaggc gccgacctcc 10321 cggggcgcta tgacgtcctg ggtgcattcc aggaccaggg tgggcacccg cacgcttttg 10381 aggtcgtcgc gggagtccga caggaacgtg gtccgggcga agacgcgcgc catgtccggg 10441 tcggtggcgc agaagctgtt cctcagttcg tcgcccagtt cgggccggtc cgggttcccc 10501 atgatcaccg gtgccatcgc ggccgaccag cccaggtagt tcgactccag ggacgccagc 10561 agctcgtcga tgtcggccgc gctgaacccg ccccggtagc cgtcgtcgtc gaggtagcgc 10621 ggcgacggcg ccaccatgac cagcgcgccg atccgctccg gggccgtgcg ggccgcgagg 10681 acaccgatca tcgcgctgac ggagtgcccg acgaacaccg cgtcgcgcag gtcgagcgcc 10741 tcgcacacct ccaccgcgtc gcgggcgtac ccgtccaggg aggcgtaacg cttctccgag 10801 aacgcggacg ggtcggagcg gcccgacccc acgtagtcga agagcacgac ccggtggtcc 10861 cgggccaggg cgggcaccgt cgcccgccac atgttctggt cgcagccgaa cccgtgggcc 10921 agcaccaccg ccggcccctg cgggtcgccg gtgacggtga cgttgttcct gcgggttaca 10981 tccataccgg ccagtctctc aggccccggc cggtactccg gcacggcgcc gccccgccgg 11041 gcgcggcccg gtgcccggcc ccgcccggac gggcaccggc gaaaaccgcc gagaggggcg 11101 tgaagggggg cggctgcggc caggatggag gcatggcata ccacgtcgac tccgaggccg 11161 ggcggctgcg ccgggtgatc ctgcaccggc ccgacctcga gctcaaaagg ctcacgccca 11221 gcaacaagga cgcccttctc ttcgacgacg tgctgtgggt gcgccgggcg cgcgccgagc 11281 acgacgggtt cgccgacgtc ctgcgcgacc gcggggtcgc ggtccacctc ttcggcgacc 11341 tgctcaccga gaccctggag atccccgagg cccgcgccct cgtcctcgac cgggtcttcg 11401 acgagaagga gtacggcccg ctcgccaccg acccgctgcg ggccgccttc gagaagctgc 11461 ccgcccggga gctgtccgag gccctggtcg gcgggatgac caagcgggag ttcctgcagg 11521 ggcacgcgga gccgacctcc gtccggttcc acgtcatgga cctcgacgac ttcctgctgc 11581 ggcccctgcc caaccacctc ttcacccgcg acacctccgc ctggatctac gacggggtcg 11641 ccatcaacgc catgcgcctg cccgcccggc agcgcgagac cgtgcacttc gaggcgatct 11701 accggcacca cccgctcttc cgcgacgaga cgttccgcgt ctggtcccag gggcaggccg 11761 accacccctc caccatcgag ggcggcgacg tgctggtgat cggcaacggc gccgtgctca 11821 tagggatgag cgagcgcacc accccgcagg ccgtggagat gctggcgcac aagctgttcg 11881 cggcgggctc cgcgcgcacc atcgtcgcgc tcgacatgcc caagcggcgc gccttcatgc 11941 acctcgacac ggtgatgacc atggtcgacg gcgacacctt cacccagtac gccgggctcg 12001 gcatgctgcg ctcgtacacc atcgagccgg gggtcggcga gcgggaactg aaggtcaccg 12061 accatccgcc ggagcacatg caccgcgcga tcgccgccgc gctcggcctc ggggagat //