LOCUS       NZ_KQ948006             7236 bp    DNA     linear   CON 21-APR-2024
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_s023, whole genome
            shotgun sequence.
ACCESSION   NZ_KQ948006
VERSION     NZ_KQ948006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7236)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Draft genome sequence of Streptomyces curacoi DSM 40107, type strain
            for the species Streptomyces curacoi
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7236)
  AUTHORS   Ruckert,C., Winkler,A., Kalinowski,J., Kampfer,P. and Glaeser,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-OCT-2015) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-OCT-2014
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.7x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_001513975.1-RS_2024_04_21
            Annotation Date                   :: 04/21/2024 02:05:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,531
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,251
            CDSs (with protein)               :: 7,251
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 204
            CDSs (without protein)            :: 204
            Pseudo Genes (ambiguous residues) :: 0 of 204
            Pseudo Genes (frameshifted)       :: 91 of 204
            Pseudo Genes (incomplete)         :: 154 of 204
            Pseudo Genes (internal stop)      :: 21 of 204
            Pseudo Genes (multiple problems)  :: 54 of 204
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:06:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7236
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KQ948006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..7236
                     /country="Argentina: Curacoi"
                     /culture_collection="DSM:40107"
                     /db_xref="taxon:146536"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces curacoi"
                     /strain="DSM 40107"
                     /submitter_seqid="PRJNA299217_s023"
                     /type_material="type strain of Streptomyces curacoi"
     region          1..7236
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..7236
                     /SMILES="NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..7236
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[22:>7236](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      23..>7236
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            23..>7236
                     /locus_tag="AQI70_RS36730"
                     /old_locus_tag="AQI70_36730"
     CDS             23..>7236
                     /NRPS_PKS="Domain: TIGR01720 (1-155). E-value: 3.8e-36.
                     Score: 116.2. Matches aSDomain:
                     nrpspksdomains_AQI70_RS36730_TIGR01720.1"
                     /NRPS_PKS="Domain: Condensation_DCL (164-463). E-value:
                     1.1e-102. Score: 335.1. Matches aSDomain:
                     nrpspksdomains_AQI70_RS36730_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (627-1015). E-value:
                     4.8e-93. Score: 303.9. Matches aSDomain:
                     nrpspksdomains_AQI70_RS36730_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1118-1186). E-value: 1.2e-27.
                     Score: 87.8. Matches aSDomain:
                     nrpspksdomains_AQI70_RS36730_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1200-1501). E-value:
                     6.3e-108. Score: 352.2. Matches aSDomain:
                     nrpspksdomains_AQI70_RS36730_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1667-2055). E-value:
                     4.1e-92. Score: 300.8. Matches aSDomain:
                     nrpspksdomains_AQI70_RS36730_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2170-2234). E-value: 2.5e-22.
                     Score: 70.8. Matches aSDomain:
                     nrpspksdomains_AQI70_RS36730_PCP.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="AQI70_RS36730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_36730"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_244181997.1"
                     /sec_met_domain="Condensation (E-value: 1.6e-70, bitscore:
                     223.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 3.9e-107, bitscore:
                     344.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.9e-19, bitscore:
                     54.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSVKEQLAGVPDKGIGYGLLRFLNAETGSELAELPDGQITFNYL
                     GDLAEVPSRSGHDSWVPAPEAGGLQAPSGADMPVLSALDVTAAVTGEEPRLSAEFSFPS
                     GVLSPAEVRDLADLWVAALEGLARHVSAPGAGGLTPSDLPLVKVSQQDIDRWESRYPRL
                     ADVWSLTPLQSGLLFHAALADTSFDAYRIQLVFHLGGQVDADRMRAAGQALLDRHAALR
                     TAFVTADNGEPVQLVVDGVTLPWREIDLTAADAGPAVDRFLAEDLGRHFALDTPPLLRM
                     TLLRTGADRAELVLTSHHLLFDGWSLPVLMTELLRLYATAGDPSGLPRPRDFRQFLRWL
                     AQRDRTASEWAWADELDGVEEPTLLAPVLTGPGTGPDDDPDGIGRLHVPLSTADAMLLT
                     RRAAELGVTVNTVLQSAWGLLLAQLTGRQDVVFGTTVSGRPAEVAGVDTMVGLFVNTVP
                     TRVRFTPYDTVADLLTGLQQRQAALLEHHHHGLTELHRLTGLDVLFDTLVAYESYPVDR
                     AGITEANTAAGVEITGIRPFTITHYPLTLLAAADPHLRVTLQYQPQALSATAAEELAER
                     LAHVLRLLTGDPATPLVSLDTLLPGERDRLLHAHNDTKVPLPDLTVADLTGRQAARTPE
                     AIAVADEHGSLTYRELEAEANRLAHALIARGAGPESVIAVALPRSARLVTVILGVLKSG
                     AAYLPVDPDFPGTRLDHVLSDARPLLILTDAATSATLPCPETPRLLVDTIPAAADTDPG
                     RRARPDSAAYVMYTSGSSGTPKGVTITHRNVVNGVAGLVDSLGVPPGGRTLAGTSISFD
                     VSVFEMFTTLSTGGTVEVVRDVLALGERENWAGGVLSTVPSAFGELAERLAGRVTAEAV
                     VFAGEALSAGLADRVRQSLPGARVVNAYGQSETFYATTFTLPDDRDLPSDAAVPIGLPL
                     GNVRVYVLGPGLDPVPTGVTGELYVAGACVGRGYLGRSGPTADRFVPDPFGPPGSRMYR
                     TGDLGRRNAHGELEYTGRADAQVKVRGYRIEPAEVEAALAEHPAVGQVVVIARATGAER
                     RLVAYVTPGGPAPAEEIRAFAESRLPAYMVPSAVVLLDRFPLTPSGKLDRRALPEPEFT
                     GTAYRAPRTRGEDALARLFAEVLGVDRVGVDDDFFALGGHSLLATRLTGRIRAALGAEV
                     SIRAVLEAPTVARLAARLRDGARLRPALTRARRPDRIPLSYAQRRMWFIDRFEGPSATY
                     NLPLAVRLNGLLDVPALASAVVDLLGRHESLRTLIAEDEAGTAYQRVLAAEQVMPDIPV
                     LPVTEDDVPRLITECAAHEFDLYTELPLRVRLLRIAPDVHVLVLVVHHIAADGGSAAPL
                     TRDLSVAYAARRAGSAPKWPDLPVQYADYTLWHNGMLGAEHDPDSLLAEQFAYWRAELA
                     DAPGPIALPTDRPRPAVAGHRGDRVDFAIDAELMAAVDELAQSRGATAAMVLQAALAVL
                     LHQLGAGDDITIGSPIAGRTDEALTDLVGFFVNTWVLRAGLSGNPSFNRLLEEVRGKAL
                     AAYDHQDAPFERLVELLNPDRSTAHHPLFQVMFAWQNTAPLDLDLPGLRVTAEPVPALT
                     AKFDLLVNLAPDPEGGASGAIEYATELFDRPSVELLGDRFLRVLRRVVTEPETRIGAVD
                     ALDAAERHRLLGELNDTRAPLPALTVADLFARQAERTPHTTALVWQDTEVTYRQLHQRA
                     GRLARVLAGRGVGPEVLVAVALPRTADLVVAILAVLMSGGVHLPVDPAHPSRRLGHILA
                     DAHPHLVLTDTATAAELPLDGPSRLMLDRLHDVPEREPSGVRPDNLAYLMYTSGTTGTP
                     KGVGITHQALTNGVRALIRTADVTPRTRMLAGTSVNFDVSLFEMFTTLCAGGTVELVRD
                     ALVLGERNGWTGGVLSTVPSVLAGLADDIAGRTGVDTVVLAGEALTTRLARQVRAALPD
                     ARMINAYGQSESFYASAFEVDDAAALPDTGVVPVGRPLANMRMYVLGRGLVPVPPGAVG
                     ELYVGGLVGRGYRGRPGLTAERFVPDPFGPPGARMYRTGDLARITGDGQVECVGRADSQ
                     MKVRGFRIEAGEIEAVLTGHPGVAQAVVRAWEDAAGGKRLVAYVVPVGPGTLDDVDLTA
                     GMSVTELRGHVAARLPDYMVPAAFVVLDRLPLNANGKLDRAALPEPEQVGDAYRAPESV
                     PEQVLAGVYAEVLGLDRVGVDDDFFAIGGDSIRSIQVVARAKTQGLAITPRQVFECRTV
                     AELARAALPEGADGGTPVLAELPGGAVGWMPLLPMARYLLELGGSHDRYAMSMVLELPD
                     GITEDGLIATLAAVIERHDVLRSTLTTGPEPGLFVGAPGSVDPAAWLRVVDAAATDEWE
                     RQAAAELDAAAARLAPSAGVMGQFVWLRPTTGPGRLLVVLHHLVVDGVSWRVLLGDLVA
                     "
     aSDomain        26..487
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS36730_TIGR01720.1"
                     /evalue="3.80E-36"
                     /label="AQI70_RS36730_TIGR01720.1"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="155"
                     /protein_start="1"
                     /score="116.2"
                     /tool="antismash"
                     /translation="KSVKEQLAGVPDKGIGYGLLRFLNAETGSELAELPDGQITFNYLG
                     DLAEVPSRSGHDSWVPAPEAGGLQAPSGADMPVLSALDVTAAVTGEEPRLSAEFSFPSG
                     VLSPAEVRDLADLWVAALEGLARHVSAPGAGGLTPSDLPLVKVSQQDIDR"
     CDS_motif       32..94
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0001"
                     /evalue="1.40E-09"
                     /label="NRPS-E6"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="24"
                     /protein_start="3"
                     /score="30.1"
                     /tool="antismash"
                     /translation="VKEQLAGVPDKGIGYGLLRFL"
     aSDomain        515..1411
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS36730_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.10E-102"
                     /label="AQI70_RS36730_Condensation_DCL.1"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="463"
                     /protein_start="164"
                     /score="335.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHLLFDG"
                     /tool="antismash"
                     /translation="DVWSLTPLQSGLLFHAALADTSFDAYRIQLVFHLGGQVDADRMRA
                     AGQALLDRHAALRTAFVTADNGEPVQLVVDGVTLPWREIDLTAADAGPAVDRFLAEDLG
                     RHFALDTPPLLRMTLLRTGADRAELVLTSHHLLFDGWSLPVLMTELLRLYATAGDPSGL
                     PRPRDFRQFLRWLAQRDRTASEWAWADELDGVEEPTLLAPVLTGPGTGPDDDPDGIGRL
                     HVPLSTADAMLLTRRAAELGVTVNTVLQSAWGLLLAQLTGRQDVVFGTTVSGRPAEVAG
                     VDTMVGLFVNTVPTRVRF"
     aSModule        515..3580
                     /complete
                     /domains="nrpspksdomains_AQI70_RS36730_Condensation_DCL.1"
                     /domains="nrpspksdomains_AQI70_RS36730_AMP-binding.1"
                     /domains="nrpspksdomains_AQI70_RS36730_PCP.1"
                     /locus_tags="AQI70_RS36730"
                     /monomer_pairings="Leu -> Leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       521..562
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0002"
                     /evalue="2.90E-03"
                     /label="C1_DCL_004-017"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="180"
                     /protein_start="166"
                     /score="10.2"
                     /tool="antismash"
                     /translation="WSLTPLQSGLLFHA"
     CDS_motif       584..700
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0003"
                     /evalue="5.00E-15"
                     /label="C2_DCL_024-062"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="226"
                     /protein_start="187"
                     /score="47.7"
                     /tool="antismash"
                     /translation="DAYRIQLVFHLGGQVDADRMRAAGQALLDRHAALRTAFV"
     CDS_motif       914..976
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0004"
                     /evalue="3.90E-10"
                     /label="C3_DCL_135-156"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="318"
                     /protein_start="297"
                     /score="32.2"
                     /tool="antismash"
                     /translation="HHLLFDGWSLPVLMTELLRLY"
     CDS_motif       1307..1402
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0005"
                     /evalue="7.60E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="460"
                     /protein_start="428"
                     /score="60.1"
                     /tool="antismash"
                     /translation="DVVFGTTVSGRPAEVAGVDTMVGLFVNTVPTR"
     CDS_motif       1451..1564
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0006"
                     /evalue="3.30E-14"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="514"
                     /protein_start="476"
                     /score="45.2"
                     /tool="antismash"
                     /translation="QQRQAALLEHHHHGLTELHRLTGLDVLFDTLVAYESYP"
     aSDomain        1904..3067
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS36730_AMP-binding.1"
                     /evalue="4.80E-93"
                     /label="AQI70_RS36730_AMP-binding.1"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1015"
                     /protein_start="627"
                     /score="303.9"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="RQAARTPEAIAVADEHGSLTYRELEAEANRLAHALIARGAGPESV
                     IAVALPRSARLVTVILGVLKSGAAYLPVDPDFPGTRLDHVLSDARPLLILTDAATSATL
                     PCPETPRLLVDTIPAAADTDPGRRARPDSAAYVMYTSGSSGTPKGVTITHRNVVNGVAG
                     LVDSLGVPPGGRTLAGTSISFDVSVFEMFTTLSTGGTVEVVRDVLALGERENWAGGVLS
                     TVPSAFGELAERLAGRVTAEAVVFAGEALSAGLADRVRQSLPGARVVNAYGQSETFYAT
                     TFTLPDDRDLPSDAAVPIGLPLGNVRVYVLGPGLDPVPTGVTGELYVAGACVGRGYLGR
                     SGPTADRFVPDPFGPPGSRMYRTGDLGRRNAHGELEYTGRADAQVKVR"
     CDS_motif       2084..2125
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0007"
                     /evalue="1.70E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="701"
                     /protein_start="687"
                     /score="14.9"
                     /tool="antismash"
                     /translation="LGVLKSGAAYLPVD"
     CDS_motif       2306..2365
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0008"
                     /evalue="8.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="781"
                     /protein_start="761"
                     /score="27.5"
                     /tool="antismash"
                     /translation="AYVMYTSGSSGTPKGVTITH"
     CDS_motif       2858..2947
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0009"
                     /evalue="5.80E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="975"
                     /protein_start="945"
                     /score="41.0"
                     /tool="antismash"
                     /translation="PTGVTGELYVAGACVGRGYLGRSGPTADRF"
     CDS_motif       3032..3097
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0010"
                     /evalue="1.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1025"
                     /protein_start="1003"
                     /score="33.2"
                     /tool="antismash"
                     /translation="YTGRADAQVKVRGYRIEPAEVE"
     CDS_motif       3302..3328
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0011"
                     /evalue="2.00E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1102"
                     /protein_start="1093"
                     /score="4.9"
                     /tool="antismash"
                     /translation="GKLDRRALP"
     aSDomain        3377..3580
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS36730_PCP.1"
                     /evalue="1.20E-27"
                     /label="AQI70_RS36730_PCP.1"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1186"
                     /protein_start="1118"
                     /score="87.8"
                     /tool="antismash"
                     /translation="EDALARLFAEVLGVDRVGVDDDFFALGGHSLLATRLTGRIRAALG
                     AEVSIRAVLEAPTVARLAARLRD"
     aSDomain        3623..4525
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS36730_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="6.30E-108"
                     /label="AQI70_RS36730_Condensation_LCL.1"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1501"
                     /protein_start="1200"
                     /score="352.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIAADG"
                     /tool="antismash"
                     /translation="DRIPLSYAQRRMWFIDRFEGPSATYNLPLAVRLNGLLDVPALASA
                     VVDLLGRHESLRTLIAEDEAGTAYQRVLAAEQVMPDIPVLPVTEDDVPRLITECAAHEF
                     DLYTELPLRVRLLRIAPDVHVLVLVVHHIAADGGSAAPLTRDLSVAYAARRAGSAPKWP
                     DLPVQYADYTLWHNGMLGAEHDPDSLLAEQFAYWRAELADAPGPIALPTDRPRPAVAGH
                     RGDRVDFAIDAELMAAVDELAQSRGATAAMVLQAALAVLLHQLGAGDDITIGSPIAGRT
                     DEALTDLVGFFVNTWVLRAG"
     aSModule        3623..6724
                     /complete
                     /domains="nrpspksdomains_AQI70_RS36730_Condensation_LCL.1"
                     /domains="nrpspksdomains_AQI70_RS36730_AMP-binding.2"
                     /domains="nrpspksdomains_AQI70_RS36730_PCP.2"
                     /locus_tags="AQI70_RS36730"
                     /monomer_pairings="Leu -> Leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       3689..3799
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0012"
                     /evalue="2.20E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1259"
                     /protein_start="1222"
                     /score="42.6"
                     /tool="antismash"
                     /translation="ATYNLPLAVRLNGLLDVPALASAVVDLLGRHESLRTL"
     CDS_motif       4010..4075
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0013"
                     /evalue="4.30E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1351"
                     /protein_start="1329"
                     /score="22.5"
                     /tool="antismash"
                     /translation="VHHIAADGGSAAPLTRDLSVAY"
     CDS_motif       4124..4159
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0014"
                     /evalue="3.40E-03"
                     /label="C4_LCL_164-176"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1379"
                     /protein_start="1367"
                     /score="10.2"
                     /tool="antismash"
                     /translation="QYADYTLWHNGM"
     CDS_motif       4430..4519
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0015"
                     /evalue="9.40E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1499"
                     /protein_start="1469"
                     /score="46.9"
                     /tool="antismash"
                     /translation="DITIGSPIAGRTDEALTDLVGFFVNTWVLR"
     CDS_motif       4574..4687
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0016"
                     /evalue="2.20E-23"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1555"
                     /protein_start="1517"
                     /score="74.7"
                     /tool="antismash"
                     /translation="KALAAYDHQDAPFERLVELLNPDRSTAHHPLFQVMFAW"
     aSDomain        5024..6187
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS36730_AMP-binding.2"
                     /evalue="4.10E-92"
                     /label="AQI70_RS36730_AMP-binding.2"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="2055"
                     /protein_start="1667"
                     /score="300.8"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="FARQAERTPHTTALVWQDTEVTYRQLHQRAGRLARVLAGRGVGPE
                     VLVAVALPRTADLVVAILAVLMSGGVHLPVDPAHPSRRLGHILADAHPHLVLTDTATAA
                     ELPLDGPSRLMLDRLHDVPEREPSGVRPDNLAYLMYTSGTTGTPKGVGITHQALTNGVR
                     ALIRTADVTPRTRMLAGTSVNFDVSLFEMFTTLCAGGTVELVRDALVLGERNGWTGGVL
                     STVPSVLAGLADDIAGRTGVDTVVLAGEALTTRLARQVRAALPDARMINAYGQSESFYA
                     SAFEVDDAAALPDTGVVPVGRPLANMRMYVLGRGLVPVPPGAVGELYVGGLVGRGYRGR
                     PGLTAERFVPDPFGPPGARMYRTGDLARITGDGQVECVGRADSQMKVR"
     CDS_motif       5210..5251
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0017"
                     /evalue="1.90E-01"
                     /label="NRPS-A_a2"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1743"
                     /protein_start="1729"
                     /score="5.8"
                     /tool="antismash"
                     /translation="LAVLMSGGVHLPVD"
     CDS_motif       5429..5488
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0018"
                     /evalue="1.40E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="1822"
                     /protein_start="1802"
                     /score="26.9"
                     /tool="antismash"
                     /translation="AYLMYTSGTTGTPKGVGITH"
     CDS_motif       5981..6067
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0019"
                     /evalue="1.10E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="2015"
                     /protein_start="1986"
                     /score="37.0"
                     /tool="antismash"
                     /translation="PPGAVGELYVGGLVGRGYRGRPGLTAERF"
     CDS_motif       6152..6217
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0020"
                     /evalue="1.50E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="2065"
                     /protein_start="2043"
                     /score="30.0"
                     /tool="antismash"
                     /translation="CVGRADSQMKVRGFRIEAGEIE"
     CDS_motif       6458..6484
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0021"
                     /evalue="7.50E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="2154"
                     /protein_start="2145"
                     /score="3.4"
                     /tool="antismash"
                     /translation="GKLDRAALP"
     aSDomain        6533..6724
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_RS36730_PCP.2"
                     /evalue="2.50E-22"
                     /label="AQI70_RS36730_PCP.2"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="2234"
                     /protein_start="2170"
                     /score="70.8"
                     /tool="antismash"
                     /translation="EQVLAGVYAEVLGLDRVGVDDDFFAIGGDSIRSIQVVARAKTQGL
                     AITPRQVFECRTVAELARA"
     CDS_motif       6851..6949
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0022"
                     /evalue="4.50E-05"
                     /label="C2_dual_024-063"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="2309"
                     /protein_start="2276"
                     /score="16.0"
                     /tool="antismash"
                     /translation="YAMSMVLELPDGITEDGLIATLAAVIERHDVLR"
     CDS_motif       7166..7231
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_RS36730_0023"
                     /evalue="7.60E-10"
                     /label="NRPS-E2"
                     /locus_tag="AQI70_RS36730"
                     /protein_end="2403"
                     /protein_start="2381"
                     /score="31.1"
                     /tool="antismash"
                     /translation="LLVVLHHLVVDGVSWRVLLGDL"
ORIGIN
        1 cggggctgtt gttggtgggt tggtgaagtc ggtcaaggag cagttggccg gggtgccgga
       61 caaggggatc ggttatgggt tgttgcggtt cctgaacgcg gagacgggga gtgagttggc
      121 ggagctgccg gacgggcaga tcaccttcaa ctacctgggc gacctcgcgg aagtcccctc
      181 ccgttcagga cacgacagct gggttcccgc acccgaggcg ggcgggctgc aagcgccgtc
      241 gggcgcggac atgcccgtcc tgtccgccct cgacgtgacc gccgcggtca ccggggagga
      301 gcctcggctg tccgccgagt tcagcttccc ctccggggtg ctgtccccgg cggaggtacg
      361 ggacctcgcc gacctgtggg tggccgccct ggaagggctc gcccggcacg tcagtgcccc
      421 tggggcgggc ggcctgaccc cctccgacct gccgctggtc aaggtgagcc agcaggacat
      481 cgaccggtgg gagtcccgtt acccccggct cgccgacgta tggtcgctga ccccgctcca
      541 gtccgggctg ctcttccatg ccgcgctggc cgacacgtcc ttcgacgcct accggattca
      601 gcttgtcttc catctgggcg gacaggtcga cgcggaccgc atgcgggcgg ccggccaggc
      661 cctgctcgac cggcacgccg ccctgcgtac ggcattcgtc accgcggaca acggagagcc
      721 ggtgcaactc gtcgtcgacg gggtgaccct gccctggcgg gagatcgacc tgaccgccgc
      781 cgacgccggt ccggccgtcg accggttcct ggccgaggac ctgggccggc acttcgccct
      841 ggacaccccg ccgctgctgc ggatgaccct gctgcgcacc ggcgccgacc gtgccgaact
      901 cgtcctcacc tcgcaccatc tgctgttcga cggctggtcg ttgccggtcc tgatgaccga
      961 actgctgcgg ctgtacgcca ccgccggcga cccgtccggc ctgccccggc cgcgcgactt
     1021 ccggcagttc ctgcggtggc tggcccaacg agatcgcacg gcctccgagt gggcatgggc
     1081 cgacgaactc gatggcgtcg aggaacccac cctgctcgcc cccgtcctca ccgggccggg
     1141 aaccggcccc gacgacgatc ccgacggcat cggacggctc cacgtacccc tgtccaccgc
     1201 cgacgcgatg ctcctgaccc ggcgcgcggc ggaactcggc gtcacggtca acaccgtgct
     1261 ccagagcgcc tggggactgc tgctggcgca gctcaccgga cggcaggacg tcgtgttcgg
     1321 caccaccgtc tccggccggc cggccgaagt cgccggagtg gacacgatgg tcggactgtt
     1381 cgtcaacacg gtcccgacac gggtgcggtt caccccgtac gacaccgtcg ccgacctgct
     1441 gaccgggttg cagcagcggc aggccgcgct gctcgaacac caccaccacg ggctcaccga
     1501 actgcaccgg ctgaccgggc tggacgtgct gttcgacacc ctggtcgcct acgagtccta
     1561 cccggtcgac cgcgcgggca tcaccgaggc caacaccgcc gccggtgtcg agatcaccgg
     1621 catccgcccg ttcaccatca cccactaccc gctcaccctg ctcgccgccg ccgacccgca
     1681 cctgcgcgtc acgctccagt accagccgca ggcgctcagc gccacggcgg ccgaagagct
     1741 ggcggagcga ctcgcccacg tactgcgcct gctcaccggc gatcccgcaa ctccgttggt
     1801 ctcgctggac acactgctgc cgggtgagcg cgaccgcctg ctgcacgcgc acaacgacac
     1861 gaaggtgccg ctgcccgacc tgaccgtggc cgacctgacg ggacgacagg ctgcccgcac
     1921 ccccgaggcg atcgccgtgg ccgacgagca cggctcgctc acctaccgcg aactcgaagc
     1981 cgaggccaac cggctggcgc atgcgctgat cgcccgcggg gccggcccgg agtccgtgat
     2041 cgcggtggcc ctgccgcggt cggcccggct ggtgacagtg atcctcggcg tcctgaagtc
     2101 gggcgccgcc tatctgcccg tcgaccccga cttccccggc acccggctcg accacgtact
     2161 gtccgacgcc cggcccctgc tgatcctcac cgacgcggcg acctcggcga cgctgccgtg
     2221 cccggagacc ccccgcctcc tcgtcgacac gatccccgcg gccgcggaca ccgatccggg
     2281 ccgtcgggca cggcccgaca gcgccgcgta cgtgatgtac acctcggggt cgagcggcac
     2341 ccccaagggc gtcaccatca cacatcgcaa cgtggtcaac ggcgtggcgg gcctggtgga
     2401 cagcctgggc gtgccgcccg gcggccggac gctggccggt acctcgatct ccttcgacgt
     2461 ctcggtgttc gagatgttca ccacgctgag cacgggcggc accgtggaag tggtccgcga
     2521 cgtgctggcg ctgggcgagc gggagaactg ggccggcggc gtgctcagca cggtgccgtc
     2581 cgccttcggg gagctcgccg agcgactggc cggccgggtc accgcggagg cggtggtctt
     2641 cgcgggtgag gcgctgtccg ccgggctggc cgaccgcgtc cggcagtcgc tgcccggcgc
     2701 acgggtggtc aacgcgtacg ggcagagcga gacgttctac gccaccacgt tcaccctgcc
     2761 cgacgaccgg gacctgccgt ccgacgccgc cgtgccgatc ggcctgccgc tgggcaatgt
     2821 gcgggtgtac gtcctcggtc ccgggctcga ccccgtgccg acgggtgtga cgggcgaact
     2881 ctacgtcgcg ggcgcgtgcg tgggccgggg atacctgggc cgctccgggc ccaccgccga
     2941 ccggttcgtg ccggacccgt tcggaccgcc cgggtcccgg atgtaccgca ccggtgacct
     3001 cggccgccgc aacgcccacg gtgaactcga atacaccggg cgggccgacg cgcaggtgaa
     3061 ggtccgcggc taccgcatcg aacccgcgga ggtggaggcg gcgctggccg aacaccccgc
     3121 cgtgggccag gtcgtggtca tcgccagggc caccggcgcg gagcgcaggc tggtggccta
     3181 cgtgacgccg ggcggccccg cgccggcgga agagatacgc gccttcgccg agagccggct
     3241 gcccgcgtac atggtgccct ccgccgtggt gctgctggac cggttcccgc tgacgcccag
     3301 cggaaagctg gaccgacgcg ccctgcccga gccggagttc accggtactg cctaccgggc
     3361 cccgcgcacc cggggcgagg acgccctggc gcggctgttc gccgaggtcc tcggggtgga
     3421 ccgggtcggt gtggacgacg acttcttcgc cctcggcggc cactccctgc tggccacccg
     3481 gctgaccggc cggattcgcg ccgcactggg agcggaggtc tccatccgcg ccgtactgga
     3541 ggcaccgacg gtcgcccggc tggccgcccg gctgcgggac ggcgcacgcc tgcggcccgc
     3601 actgacccgc gcgcggcgcc cggaccgcat cccgctgtcg tacgcgcagc gccgcatgtg
     3661 gttcatcgac cgcttcgagg ggccgtccgc cacctacaac ctgccgctcg cggtgcgcct
     3721 caacggcttg ctggacgtgc ccgcgctcgc ttcggcggtg gtggacctgc tcggccggca
     3781 cgagagcctg cgcaccctga tcgccgagga cgaggcgggg accgcatacc aacgcgtcct
     3841 tgccgccgag caggtgatgc cggacatccc ggtcctgccg gtgaccgagg acgacgtacc
     3901 ccggctgatc accgagtgcg ccgcgcacga attcgacctg tacaccgaac tgccgctccg
     3961 tgtaaggctg ttgcgtatcg cacccgacgt gcatgtgctc gtgctggtcg tccaccacat
     4021 cgccgccgac ggcgggtccg cggcaccgct gacccgggac ctctccgtcg cctacgcggc
     4081 acggcgcgcg ggcagcgcgc cgaagtggcc ggacctgccg gtgcagtacg ccgactacac
     4141 gctgtggcac aacggcatgc tcggcgccga gcacgacccg gacagcctgc tcgccgagca
     4201 gttcgcctac tggcgcgccg aactggccga cgcgcccggg cccatcgcgc tgccgaccga
     4261 ccggcccagg cccgcggtgg ccggccaccg cggtgaccgc gtcgacttcg cgatcgacgc
     4321 ggagctgatg gcggcggtcg acgagctggc acagtcccgc ggggccaccg cggccatggt
     4381 gctgcaggcg gcgctggccg tgctgctgca ccagctgggc gcgggcgacg acatcaccat
     4441 cggctcgccg atcgcgggcc gtaccgacga ggcgctcacc gacctggtcg ggttcttcgt
     4501 caacacctgg gtgctgcgcg ccggactgtc cggcaacccc tcgttcaacc ggcttctgga
     4561 agaggtccgc ggcaaggcgc tggcggccta cgaccaccag gacgcgccct tcgagcggct
     4621 ggtggaactg ctcaacccgg accgctccac cgcgcaccac ccactgttcc aggtcatgtt
     4681 cgcctggcag aacacggccc cactggacct cgacctgccg ggcctgcggg tgaccgccga
     4741 gccggtcccg gccctcaccg ccaagttcga cctgctggtc aacctcgccc cggatccgga
     4801 gggcggcgcc tcgggcgcca tcgagtacgc caccgagctg ttcgaccgac cgagcgtcga
     4861 actgctcggc gaccgcttcc tgcgggtgct gcgccgggtg gtcacggaac cggagacgcg
     4921 gatcggcgcc gtcgacgctc tggacgccgc cgaacggcac cgccttctgg gggagttgaa
     4981 cgacacccgg gcaccgctgc ccgcgctgac ggtcgccgac ctgttcgccc ggcaggcgga
     5041 gcggacaccg cacacgaccg cgctggtctg gcaggacacg gaggtgacct accgacagct
     5101 gcaccagcgc gccggccggc tggcccgggt gctggccggg cgcggggtgg gccccgaagt
     5161 gctggtggcc gtcgcgctgc ccaggaccgc ggacctggtc gtggcgatcc tcgccgtgct
     5221 catgtccggc ggcgtccacc tgccggtcga cccggcccac cccagtcggc gcctgggcca
     5281 catcctggcc gacgcacatc cgcacctggt cctcaccgac accgccaccg ctgccgagtt
     5341 gccgctcgac ggtccgtccc ggctgatgct cgaccggctg cacgacgtgc cggagcggga
     5401 accgtccggg gtacggccgg acaacctggc ctatctgatg tacacctccg ggaccaccgg
     5461 cacgcccaag ggggtgggca tcactcatca ggcgctcacc aacggtgtgc gcgcgctcat
     5521 ccgcacggcc gacgtgacac cgcggacccg gatgcttgcc gggacctcgg tcaatttcga
     5581 cgtgtcgctg ttcgagatgt tcaccacgct gtgcgcgggc gggaccgtcg agctcgtacg
     5641 ggacgctctc gtcctcggcg agcggaacgg ctggaccggc ggcgtgctca gcaccgtgcc
     5701 gtcggtcctc gccgggctgg cggacgacat cgccggacgc accggcgtcg acacggtcgt
     5761 gctcgccggc gaggccctga cgacgcggct ggcccggcag gtccgcgcgg cactgcccga
     5821 tgcccggatg atcaacgcat acggccagag cgagtccttc tacgcctcgg cgttcgaggt
     5881 ggacgacgcc gccgcactcc cggacacggg cgtcgtaccg gtcggcaggc cgctggccaa
     5941 catgcggatg tacgtcctgg gacgcggtct cgtcccggtg ccgcccggcg ccgtcggcga
     6001 actgtatgtc ggtggcctgg tcggccgcgg ctaccgggga cgcccggggc tgaccgccga
     6061 gcggttcgtg ccggacccgt tcgggccgcc cggggcgcgg atgtaccgca cgggagacct
     6121 ggcgcggatc accggggacg ggcaggtcga gtgcgtggga cgcgccgact cccagatgaa
     6181 ggtgcgcggc ttccgcatcg aagccgggga gatcgaggcc gtgctcacgg gccaccccgg
     6241 cgtggctcag gccgtggtgc gcgcctggga ggatgccgcc ggcggcaagc ggctggtcgc
     6301 ctacgtggtc ccggtgggac ccggcaccct cgacgacgtc gacctgaccg cgggcatgtc
     6361 ggtgaccgaa ctgcgtggcc acgtcgctgc ccggctgccc gactacatgg tgcccgccgc
     6421 gttcgtggtg ctggaccgcc tccccctgaa cgccaacggc aagctcgacc gggccgcgct
     6481 gcccgaaccg gagcaggtcg gtgacgccta ccgggcgccc gagtcggtgc cggagcaggt
     6541 cctggccggc gtctacgccg aggtgctggg gctggaccgg gtcggcgtgg acgacgactt
     6601 cttcgccatc ggcggcgaca gcatccgctc catccaggtg gtcgcccgcg cgaagacaca
     6661 gggtctggcc atcacaccgc gccaggtctt cgagtgccgg accgtggccg aactcgcccg
     6721 ggccgcgctc ccggagggcg cggacggcgg cacccccgtg ctcgcggagc tgcccggcgg
     6781 cgctgtgggc tggatgcccc tgctgcccat ggccaggtat ctgctcgaac tgggcgggag
     6841 ccacgaccgg tacgccatgt cgatggtgct cgaactcccg gacgggatca ccgaggacgg
     6901 cctgatcgcg acgctggccg ccgtgatcga acgacacgac gtgctgcgct cgaccctcac
     6961 caccgggccc gaaccgggcc tgttcgtcgg cgcccccgga tcggtggacc ccgccgcgtg
     7021 gctccgcgtc gtcgacgctg ccgcgaccga cgagtgggaa cggcaggcgg cggccgaact
     7081 ggatgccgcc gcggcacgcc tcgctccgtc cgccggcgtg atggggcagt tcgtctggct
     7141 gcggccgacg acgggccctg gtcggttgtt ggtggttttg catcatttgg tggtggatgg
     7201 ggtgtcgtgg cgggtgttgt tgggggattt ggttgc
//
